NPPA cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	NPPA
Entrez Gene ID	4878
Full Name	natriuretic peptide A
Synonyms	ANF,ANP,ATFB6,ATRST2,CDD,CDD-ANF,CDP,PND
General protein information	Preferred Names natriuretic peptide A Names natriuretic peptides A atriopeptin cardiodilatin-related peptide cardionatrin natriuretic peptide precursor A variant 1 prepronatriodilatin
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1p36.22
Summary	The protein encoded by this gene belongs to the natriuretic peptide family. Natriuretic peptides are implicated in the control of extracellular fluid volume and electrolyte homeostasis. This protein is synthesized as a large precursor (containing a signal peptide), which is processed to release a peptide from the N-terminus with similarity to vasoactive peptide, cardiodilatin, and another peptide from the C-terminus with natriuretic-diuretic activity. Mutations in this gene have been associated with atrial fibrillation familial type 6. This gene is located adjacent to another member of the natriuretic family of peptides on chromosome 1. [provided by RefSeq, Oct 2015].
Disorder MIM:	108780
Disorder Html:	Atrial fibrillation, familial, 6, 612201 (3); Atrial standstill 2, 615745 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_006172.4	NP_006163.1	natriuretic peptides A preproprotein
NM_006172.3	NP_006163.1	natriuretic peptides A preproprotein

Pathways from BioSystems

Homologies

Homo sapiens (human)	NPPA	NP_006163.1
Pan troglodytes (chimpanzee)	NPPA	XP_001141705.1
	NPPA	XP_001105465.1
Rattus norvegicus (Norway rat)	Nppa	NP_036744.1
Mus musculus (house mouse)	Nppa	NP_032751.1
Canis lupus familiaris (dog)	NPPA	XP_850357.1
Bos taurus (cattle)	NPPA	NP_776549.1

Gene Ontology
Bibliography

Related articles in PubMed

Structure and function of the Nppa-Nppb cluster locus during heart development and disease.
Man J, Barnett P, Christoffels VM
Cellular and molecular life sciences : CMLS(2018 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

increased plasma proANP should be a protective factor of hyperuricemia among middle-aged and old women
Title: Association between plasma proANP and hyperuricemia in Chinese Han women: a cross-sectional study.

ANP inhibits TGF-beta1-induced EMT in 16HBE-14o and A549 cells through cGMP/PKG signaling, by which it targets TGF-beta1/Smad3 via attenuating phosphorylation of Smad3. These findings suggest the potential of ANP in the treatment on pulmonary diseases with airway remodeling.
Title: Atrial natriuretic peptide: A novel mediator for TGF-?1-induced epithelial-mesenchymal transition in 16HBE-14o and A549 cells.

TIMP-4, NT-proANP, NT-proBNP were strongest associated with PAF and AHRE. The discriminatory performance of CHADS2-VASc for PAF was increased by addition of selected biomarkers.
Title: CHA2DS2-VASc score and blood biomarkers to identify patients with atrial high-rate episodes and paroxysmal atrial fibrillation.

the G allele of the genetic variant rs5068 in African Americans is associated with lower prevalence of metabolic syndrome and lower triglycerides values
Title: A favorable cardiometabolic profile is associated with the G allele of the genetic variant rs5068 in African Americans: The Multi-Ethnic Study of Atherosclerosis (MESA).

This study indicates that in children with community-acquired pneumonia, sTREM-1, Midregional-proANP, and Midregional-proADM blood levels have poor abilities to differentiate bacterial from viral diseases or to identify severe cases.
Title: Sensitivity and Specificity of Soluble Triggering Receptor Expressed on Myeloid Cells-1, Midregional Proatrial Natriuretic Peptide and Midregional Proadrenomedullin for Distinguishing Etiology and to Assess Severity in Community-Acquired Pneumonia.

The following NPPA gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the NPPA cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu17752	NM_006172.4 Latest version!	Homo sapiens natriuretic peptide A (NPPA), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu17752	NM_006172.3	Homo sapiens natriuretic peptide A (NPPA), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

NPPA ( NM_006172.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_006163.1 Homo sapiens natriuretic peptide A (NPPA), mRNA.

Price & Availability↑

CloneID	OHu17752
Clone ID Related Accession (Same CDS sequence)	NM_006172.4 , NM_006172.3
Accession Version	NM_006172.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 456bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-20
Organism	Homo sapiens(human)
Product	natriuretic peptides A preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC005893.1 and AA779538.1. On May 17, 2019 this sequence version replaced NM_006172.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR5189655.46023.1, SRR5189655.166306.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2154361, SAMEA2155550 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000376480.7/ ENSP00000365663.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGAGCTCCT TCTCCACCAC CACCGTGAGC TTCCTCCTTT TACTGGCATT CCAGCTCCTA 
GGTCAGACCA GAGCTAATCC CATGTACAAT GCCGTGTCCA ACGCAGACCT GATGGATTTC 
AAGAATTTGC TGGACCATTT GGAAGAAAAG ATGCCTTTAG AAGATGAGGT CGTGCCCCCA 
CAAGTGCTCA GTGAGCCGAA TGAAGAAGCG GGGGCTGCTC TCAGCCCCCT CCCTGAGGTG 
CCTCCCTGGA CCGGGGAAGT CAGCCCAGCC CAGAGAGATG GAGGTGCCCT CGGGCGGGGC 
CCCTGGGACT CCTCTGATCG ATCTGCCCTC CTAAAAAGCA AGCTGAGGGC GCTGCTCACT 
GCCCCTCGGA GCCTGCGGAG ATCCAGCTGC TTCGGGGGCA GGATGGACAG GATTGGAGCC 
CAGAGCGGAC TGGGCTGTAA CAGCTTCCGG TACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006163.1
CDS	100..555
Translation	MSSFSTTTVSFLLLLAFQLLGQTRANPMYNAVSNADLMDFKNLLDHLEEKMPLEDEVVPPQVLSEPNEEAGAALSPLPEVPPWTGEVSPAQRDGGALGRGPWDSSDRSALLKSKLRALLTAPRSLRRSSCFGGRMDRIGAQSGLGCNSFRY

Target ORF information:

RefSeq Version	NM_006172.4
Organism	Homo sapiens(human)
Definition	Homo sapiens natriuretic peptide A (NPPA), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006172.4

ORF Insert Sequence:

ATGAGCTCCT TCTCCACCAC CACCGTGAGC TTCCTCCTTT TACTGGCATT CCAGCTCCTA 
GGTCAGACCA GAGCTAATCC CATGTACAAT GCCGTGTCCA ACGCAGACCT GATGGATTTC 
AAGAATTTGC TGGACCATTT GGAAGAAAAG ATGCCTTTAG AAGATGAGGT CGTGCCCCCA 
CAAGTGCTCA GTGAGCCGAA TGAAGAAGCG GGGGCTGCTC TCAGCCCCCT CCCTGAGGTG 
CCTCCCTGGA CCGGGGAAGT CAGCCCAGCC CAGAGAGATG GAGGTGCCCT CGGGCGGGGC 
CCCTGGGACT CCTCTGATCG ATCTGCCCTC CTAAAAAGCA AGCTGAGGGC GCTGCTCACT 
GCCCCTCGGA GCCTGCGGAG ATCCAGCTGC TTCGGGGGCA GGATGGACAG GATTGGAGCC 
CAGAGCGGAC TGGGCTGTAA CAGCTTCCGG TACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

NPPA ( NM_006172.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_006163.1 Homo sapiens natriuretic peptide A (NPPA), mRNA.

Price & Availability↑

CloneID	OHu17752
Clone ID Related Accession (Same CDS sequence)	NM_006172.4 , NM_006172.3
Accession Version	NM_006172.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 456bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-22
Organism	Homo sapiens(human)
Product	natriuretic peptides A preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC005893.1 and AA779538.1. This sequence is a reference standard in the RefSeqGene project. On Jun 13, 2009 this sequence version replaced NM_006172.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC005893.1, ERR279837.2678.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2154361, SAMEA2155550 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAGCTCCT TCTCCACCAC CACCGTGAGC TTCCTCCTTT TACTGGCATT CCAGCTCCTA 
GGTCAGACCA GAGCTAATCC CATGTACAAT GCCGTGTCCA ACGCAGACCT GATGGATTTC 
AAGAATTTGC TGGACCATTT GGAAGAAAAG ATGCCTTTAG AAGATGAGGT CGTGCCCCCA 
CAAGTGCTCA GTGAGCCGAA TGAAGAAGCG GGGGCTGCTC TCAGCCCCCT CCCTGAGGTG 
CCTCCCTGGA CCGGGGAAGT CAGCCCAGCC CAGAGAGATG GAGGTGCCCT CGGGCGGGGC 
CCCTGGGACT CCTCTGATCG ATCTGCCCTC CTAAAAAGCA AGCTGAGGGC GCTGCTCACT 
GCCCCTCGGA GCCTGCGGAG ATCCAGCTGC TTCGGGGGCA GGATGGACAG GATTGGAGCC 
CAGAGCGGAC TGGGCTGTAA CAGCTTCCGG TACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006163.1
CDS	100..555
Translation	MSSFSTTTVSFLLLLAFQLLGQTRANPMYNAVSNADLMDFKNLLDHLEEKMPLEDEVVPPQVLSEPNEEAGAALSPLPEVPPWTGEVSPAQRDGGALGRGPWDSSDRSALLKSKLRALLTAPRSLRRSSCFGGRMDRIGAQSGLGCNSFRY

Target ORF information:

RefSeq Version	NM_006172.3
Organism	Homo sapiens(human)
Definition	Homo sapiens natriuretic peptide A (NPPA), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006172.3

ORF Insert Sequence:

ATGAGCTCCT TCTCCACCAC CACCGTGAGC TTCCTCCTTT TACTGGCATT CCAGCTCCTA 
GGTCAGACCA GAGCTAATCC CATGTACAAT GCCGTGTCCA ACGCAGACCT GATGGATTTC 
AAGAATTTGC TGGACCATTT GGAAGAAAAG ATGCCTTTAG AAGATGAGGT CGTGCCCCCA 
CAAGTGCTCA GTGAGCCGAA TGAAGAAGCG GGGGCTGCTC TCAGCCCCCT CCCTGAGGTG 
CCTCCCTGGA CCGGGGAAGT CAGCCCAGCC CAGAGAGATG GAGGTGCCCT CGGGCGGGGC 
CCCTGGGACT CCTCTGATCG ATCTGCCCTC CTAAAAAGCA AGCTGAGGGC GCTGCTCACT 
GCCCCTCGGA GCCTGCGGAG ATCCAGCTGC TTCGGGGGCA GGATGGACAG GATTGGAGCC 
CAGAGCGGAC TGGGCTGTAA CAGCTTCCGG TACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Structure and function of the Nppa-Nppb cluster locus during heart development and disease.
Cellular and molecular life sciences : CMLS(2018 Jan)
Man J,Barnett P,Christoffels VM

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NPPA cDNA ORF clone, Homo sapiens(human)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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