NPHS1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	NPHS1
Entrez Gene ID	4868
Full Name	NPHS1, nephrin
Synonyms	CNF,NPHN,nephrin
General protein information	Preferred Names NPHS1, nephrin Names nephrin nephrosis 1, congenital, Finnish type (nephrin) renal glomerulus-specific cell adhesion receptor truncated NPHS1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 19 Map Location: 19q13.12
Summary	This gene encodes a member of the immunoglobulin family of cell adhesion molecules that functions in the glomerular filtration barrier in the kidney. The gene is primarily expressed in renal tissues, and the protein is a type-1 transmembrane protein found at the slit diaphragm of glomerular podocytes. The slit diaphragm is thought to function as an ultrafilter to exclude albumin and other plasma macromolecules in the formation of urine. Mutations in this gene result in Finnish-type congenital nephrosis 1, characterized by severe proteinuria and loss of the slit diaphragm and foot processes.[provided by RefSeq, Oct 2009].
Disorder MIM:	602716
Disorder Html:	Nephrotic syndrome, type 1, 256300 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_004646.3	NP_004637.1	nephrin precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	NPHS1	XP_524228.3
Homo sapiens (human)	NPHS1	NP_004637.1
Rattus norvegicus (Norway rat)	Nphs1	NP_072150.1
Mus musculus (house mouse)	Nphs1	NP_062332.2
Drosophila melanogaster (fruit fly)	sns	NP_788286.1
	NPHS1	XP_001112314.1
Canis lupus familiaris (dog)	NPHS1	XP_541685.3
Bos taurus (cattle)	NPHS1	NP_001179441.1
Danio rerio (zebrafish)	nphs1	NP_001035777.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP010742	XP_311455.4
Xenopus tropicalis (tropical clawed frog)	nphs1	XP_002940674.2

Gene Ontology
Bibliography

Related articles in PubMed

Novel mutation in the nephrin gene of a Japanese patient with congenital nephrotic syndrome of the Finnish type.
Aya K, Tanaka H, Seino Y
Kidney international57(2)401-4(2000 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Two novel putatively deleterious NPHS1 variants were identified in children with steroid-resistant nephrotic syndrome.
Title: Mutation spectrum of genes associated with steroid-resistant nephrotic syndrome in Chinese children.

WHSC1L1-L acts as a histone methyltransferase in podocytes and regulates nephrin gene expression, which may in turn contribute to the integrity of the slit diaphragm of the glomerular filtration barrier.
Title: Wolf-Hirschhorn syndrome candidate 1-like 1 epigenetically regulates nephrin gene expression.

On genetic analysis of NPHS1 a paternally derived heterozygous frame-shift mutation caused by an 8 bp deletion, resulting in a stop codon in exon 16 (c.2156-2163 delTGCACTGC causing p.L719DfsX4), and a novel, maternally derived nonsense mutation in exon 15 (c.1978G>T causing p.E660X) were identified.
Title: Congenital nephrotic syndrome with a novel NPHS1 mutation.

Case Reports: NPHS1 mutations in four Brazilian cases of congenital nephrotic syndrome.
Title: NPHS1 gene mutations confirm congenital nephrotic syndrome in four Brazilian cases: A novel mutation is described.

A novel nonsense mutation in NPHS1 linking aortic stenosis associated with congenital nephropathy, is reported.
Title: A novel nonsense mutation in NPHS1: is aortic stenosis associated with congenital nephropathy?

The following NPHS1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the NPHS1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu23046	NM_004646.3 Latest version!	Homo sapiens NPHS1 adhesion molecule, nephrin (NPHS1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$624.50-$874.30 $1249.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

NPHS1 ( NM_004646.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_004637.1 Homo sapiens NPHS1 adhesion molecule, nephrin (NPHS1), mRNA.

Price & Availability↑

CloneID	OHu23046
Clone ID Related Accession (Same CDS sequence)	NM_004646.3
Accession Version	NM_004646.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3726bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Homo sapiens(human)
Product	nephrin precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC002133.1, AF035835.1 and U95090.1. This sequence is a reference standard in the RefSeqGene project. On Oct 6, 2009 this sequence version replaced NM_004646.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF035835.1, EU642886.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 5' end.

ATGGCCCTGG GGACGACGCT CAGGGCTTCT CTCCTGCTCC TGGGGCTGCT GACTGAAGGC 
CTGGCGCAGT TGGCGATTCC TGCCTCCGTT CCCCGGGGCT TCTGGGCCCT GCCTGAAAAC 
CTGACGGTGG TGGAGGGGGC CTCAGTGGAG CTGCGTTGTG GGGTCAGCAC CCCTGGCAGT 
GCGGTGCAAT GGGCCAAAGA TGGGCTGCTC CTGGGCCCCG ACCCCAGGAT CCCAGGCTTC 
CCGAGGTACC GCCTGGAAGG GGACCCTGCT AGAGGTGAAT TCCACCTGCA CATCGAGGCC 
TGTGACCTCA GCGATGACGC GGAGTATGAG TGCCAGGTCG GCCGCTCTGA GATGGGGCCC 
GAGCTCGTGT CTCCCAGAGT GATCCTCTCC ATCCTGGTTC CTCCCAAGCT GCTCCTGCTG 
ACCCCAGAGG CAGGCACCAT GGTCACCTGG GTAGCTGGGC AGGAGTACGT GGTCAACTGT 
GTGTCTGGGG ACGCGAAGCC AGCACCTGAC ATCACCATTC TCCTGAGTGG ACAGACAATA 
TCTGACATCT CTGCAAACGT GAACGAGGGC TCCCAGCAGA AACTCTTCAC TGTGGAGGCC 
ACAGCCAGGG TGACACCCCG GAGCTCAGAT AATAGGCAGT TGCTGGTCTG TGAGGCGTCT 
AGCCCAGCAC TGGAGGCCCC CATCAAGGCC TCATTCACCG TGAATGTTCT GTTCCCTCCA 
GGACCCCCTG TCATCGAGTG GCCAGGCCTG GATGAGGGGC ACGTGCGGGC AGGACAGAGC 
TTGGAGCTGC CGTGCGTGGC CCGAGGGGGT AATCCCTTAG CCACACTGCA GTGGCTGAAG 
AATGGCCAGC CGGTGTCCAC AGCGTGGGGC ACAGAGCACA CCCAGGCGGT GGCCCGCAGT 
GTGCTGGTGA TGACCGTGAG GCCAGAAGAC CATGGAGCGC AGCTCAGCTG CGAGGCCCAC 
AACAGCGTGT CTGCAGGGAC CCAGGAGCAC GGCATCACAC TGCAGGTCAC CTTTCCCCCT 
AGTGCCATTA TTATCTTGGG ATCTGCATCC CAGACTGAGA ACAAGAACGT GACACTCTCC 
TGTGTCAGCA AGTCCAGTCG CCCGCGGGTT CTGCTACGAT GGTGGCTGGG CTGGCGGCAG 
CTGCTGCCCA TGGAGGAGAC AGTCATGGAT GGACTGCATG GCGGTCACAT CTCCATGTCC 
AACCTGACAT TCCTGGCGCG GCGGGAGGAC AACGGTCTGA CCCTCACATG TGAGGCCTTC 
AGTGAAGCCT TCACCAAGGA GACCTTCAAG AAGTCGCTCA TCCTGAACGT AAAATATCCC 
GCCCAGAAAC TGTGGATTGA GGGTCCCCCA GAGGGCCAGA AGCTCCGGGC TGGGACCCGG 
GTGAGGCTGG TGTGTTTGGC TATCGGGGGC AACCCAGAGC CCTCCCTCAT GTGGTACAAG 
GACTCGCGCA CCGTGACCGA GTCGCGGCTG CCGCAGGAGT CGCGGCGCGT GCATCTCGGC 
AGCGTGGAGA AATCTGGGAG CACCTTCTCC CGAGAGCTGG TGCTGGTCAC AGGGCCGTCG 
GACAACCAGG CCAAGTTCAC GTGCAAGGCT GGACAGCTCA GCGCGTCCAC GCAGCTGGCG 
GTGCAGTTTC CCCCAACTAA CGTGACGATC CTGGCCAACG CATCCGCACT GCGCCCGGGA 
GACGCCTTAA ACTTGACATG CGTCAGCGTC AGCAGCAATC CGCCGGTCAA CTTGTCCTGG 
GACAAGGAAG GGGAGAGGCT GGAGGGCGTG GCCGCCCCAC CCCGGAGAGC CCCATTCAAA 
GGCTCCGCCG CCGCCAGGAG CGTCCTTCTG CAAGTGTCAT CCCGCGATCA TGGCCAGCGC 
GTGACCTGCC GCGCCCACAG CGCCGAGCTC CGCGAAACCG TGAGCTCCTT CTATCGCCTC 
AACGTACTGT ACCGTCCAGA GTTCCTGGGG GAGCAGGTGC TGGTGGTGAC CGCGGTGGAG 
CAGGGCGAGG CGTTGCTGCC CGTGTCCGTG TCCGCTAACC CCGCCCCCGA GGCCTTCAAC 
TGGACCTTCC GCGGCTATCG CCTCAGTCCA GCGGGCGGCC CCCGGCATCG CATCCTGTCC 
AGCGGGGCTC TGCATCTGTG GAATGTGACC CGCGCGGACG ACGGCCTCTA TCAGCTGCAC 
TGCCAGAACT CTGAGGGCAC CGCGGAAGCG CGGCTGCGGC TGGACGTGCA CTATGCTCCC 
ACCATCCGTG CCCTCCAGGA CCCCACTGAG GTGAACGTCG GGGGTTCTGT GGACATAGTC 
TGCACTGTCG ATGCCAATCC CATCCTCCCG GGCATGTTCA ACTGGGAGAG ACTGGGAGAA 
GATGAGGAGG ACCAGAGCCT GGATGACATG GAGAAGATAT CCAGGGGACC AACGGGGCGC 
CTGCGGATTC ACCATGCCAA ACTGGCCCAG GCTGGCGCTT ACCAGTGCAT TGTGGACAAT 
GGGGTGGCGC CTCCAGCACG ACGGCTGCTC CGTCTTGTTG TCAGATTTGC CCCCCAGGTG 
GAGCACCCCA CTCCCCTAAC TAAGGTGGCT GCAGCTGGAG ACAGCACCAG TTCTGCCACC 
CTCCACTGCC GTGCCCGAGG TGTCCCCAAC ATCGTTTTCA CTTGGACAAA AAACGGGGTC 
CCTCTGGATC TCCAAGATCC CAGGTACACG GAGCACACAT ACCACCAGGG TGGTGTCCAC 
AGCAGCCTCC TGACCATTGC CAACGTGTCT GCCGCCCAGG ATTACGCCCT CTTCACATGT 
ACAGCCACCA ACGCCCTTGG CTCGGACCAA ACCAACATTC AACTTGTCAG CATCAGCCGC 
CCTGACCCTC CATCAGGATT AAAGGTTGTG AGTCTGACCC CACACTCCGT GGGGCTGGAG 
TGGAAGCCTG GCTTTGATGG GGGCCTGCCA CAGAGGTTCT GCATCAGGTA TGAGGCCCTG 
GGGACTCCAG GGTTCCACTA TGTGGATGTC GTACCACCCC AGGCCACCAC CTTCACGCTG 
ACTGGTCTAC AGCCTTCTAC AAGATACAGG GTCTGGCTGC TGGCCAGTAA TGCCTTGGGG 
GACAGTGGAC TGGCTGACAA AGGGACCCAG CTTCCCATCA CTACCCCAGG TCTCCACCAG 
CCTTCTGGAG AACCTGAAGA CCAGCTGCCC ACAGAGCCAC CTTCAGGACC CTCGGGGCTG 
CCCCTGCTGC CTGTGCTGTT CGCTCTTGGG GGGCTTCTGC TCCTCTCCAA TGCCTCCTGT 
GTCGGGGGGG TCCTCTGGCA GCGGAGACTC AGGCGTCTTG CTGAGGGCAT CTCAGAGAAG 
ACAGAGGCAG GGTCGGAAGA GGACCGAGTC AGGAACGAAT ATGAGGAGAG CCAGTGGACA 
GGAGAGCGGG ACACTCAGAG CTCCACGGTC AGCACAACAG AGGCAGAGCC GTATTACCGC 
TCCCTGAGGG ACTTCAGCCC CCAGCTGCCC CCGACGCAGG AGGAGGTGTC TTATTCCCGA 
GGTTTCACAG GTGAAGATGA GGATATGGCC TTCCCTGGGC ACTTGTATGA TGAGGTAGAA 
AGAACGTACC CCCCGTCTGG AGCCTGGGGA CCCCTCTACG ATGAAGTGCA GATGGGACCC 
TGGGACCTCC ACTGGCCTGA AGACACATAT CAGGATCCAA GAGGAATCTA TGACCAGGTG 
GCCGGAGACT TGGACACTCT GGAACCCGAT TCTCTGCCCT TCGAGCTGAG GGGACATCTG 
GTGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004637.1
CDS	157..3882
Translation	MALGTTLRASLLLLGLLTEGLAQLAIPASVPRGFWALPENLTVVEGASVELRCGVSTPGSAVQWAKDGLLLGPDPRIPGFPRYRLEGDPARGEFHLHIEACDLSDDAEYECQVGRSEMGPELVSPRVILSILVPPKLLLLTPEAGTMVTWVAGQEYVVNCVSGDAKPAPDITILLSGQTISDISANVNEGSQQKLFTVEATARVTPRSSDNRQLLVCEASSPALEAPIKASFTVNVLFPPGPPVIEWPGLDEGHVRAGQSLELPCVARGGNPLATLQWLKNGQPVSTAWGTEHTQAVARSVLVMTVRPEDHGAQLSCEAHNSVSAGTQEHGITLQVTFPPSAIIILGSASQTENKNVTLSCVSKSSRPRVLLRWWLGWRQLLPMEETVMDGLHGGHISMSNLTFLARREDNGLTLTCEAFSEAFTKETFKKSLILNVKYPAQKLWIEGPPEGQKLRAGTRVRLVCLAIGGNPEPSLMWYKDSRTVTESRLPQESRRVHLGSVEKSGSTFSRELVLVTGPSDNQAKFTCKAGQLSASTQLAVQFPPTNVTILANASALRPGDALNLTCVSVSSNPPVNLSWDKEGERLEGVAAPPRRAPFKGSAAARSVLLQVSSRDHGQRVTCRAHSAELRETVSSFYRLNVLYRPEFLGEQVLVVTAVEQGEALLPVSVSANPAPEAFNWTFRGYRLSPAGGPRHRILSSGALHLWNVTRADDGLYQLHCQNSEGTAEARLRLDVHYAPTIRALQDPTEVNVGGSVDIVCTVDANPILPGMFNWERLGEDEEDQSLDDMEKISRGPTGRLRIHHAKLAQAGAYQCIVDNGVAPPARRLLRLVVRFAPQVEHPTPLTKVAAAGDSTSSATLHCRARGVPNIVFTWTKNGVPLDLQDPRYTEHTYHQGGVHSSLLTIANVSAAQDYALFTCTATNALGSDQTNIQLVSISRPDPPSGLKVVSLTPHSVGLEWKPGFDGGLPQRFCIRYEALGTPGFHYVDVVPPQATTFTLTGLQPSTRYRVWLLASNALGDSGLADKGTQLPITTPGLHQPSGEPEDQLPTEPPSGPSGLPLLPVLFALGGLLLLSNASCVGGVLWQRRLRRLAEGISEKTEAGSEEDRVRNEYEESQWTGERDTQSSTVSTTEAEPYYRSLRDFSPQLPPTQEEVSYSRGFTGEDEDMAFPGHLYDEVERTYPPSGAWGPLYDEVQMGPWDLHWPEDTYQDPRGIYDQVAGDLDTLEPDSLPFELRGHLV

Target ORF information:

RefSeq Version	NM_004646.3
Organism	Homo sapiens(human)
Definition	Homo sapiens NPHS1 adhesion molecule, nephrin (NPHS1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004646.3

ORF Insert Sequence:

ATGGCCCTGG GGACGACGCT CAGGGCTTCT CTCCTGCTCC TGGGGCTGCT GACTGAAGGC 
CTGGCGCAGT TGGCGATTCC TGCCTCCGTT CCCCGGGGCT TCTGGGCCCT GCCTGAAAAC 
CTGACGGTGG TGGAGGGGGC CTCAGTGGAG CTGCGTTGTG GGGTCAGCAC CCCTGGCAGT 
GCGGTGCAAT GGGCCAAAGA TGGGCTGCTC CTGGGCCCCG ACCCCAGGAT CCCAGGCTTC 
CCGAGGTACC GCCTGGAAGG GGACCCTGCT AGAGGTGAAT TCCACCTGCA CATCGAGGCC 
TGTGACCTCA GCGATGACGC GGAGTATGAG TGCCAGGTCG GCCGCTCTGA GATGGGGCCC 
GAGCTCGTGT CTCCCAGAGT GATCCTCTCC ATCCTGGTTC CTCCCAAGCT GCTCCTGCTG 
ACCCCAGAGG CAGGCACCAT GGTCACCTGG GTAGCTGGGC AGGAGTACGT GGTCAACTGT 
GTGTCTGGGG ACGCGAAGCC AGCACCTGAC ATCACCATTC TCCTGAGTGG ACAGACAATA 
TCTGACATCT CTGCAAACGT GAACGAGGGC TCCCAGCAGA AACTCTTCAC TGTGGAGGCC 
ACAGCCAGGG TGACACCCCG GAGCTCAGAT AATAGGCAGT TGCTGGTCTG TGAGGCGTCT 
AGCCCAGCAC TGGAGGCCCC CATCAAGGCC TCATTCACCG TGAATGTTCT GTTCCCTCCA 
GGACCCCCTG TCATCGAGTG GCCAGGCCTG GATGAGGGGC ACGTGCGGGC AGGACAGAGC 
TTGGAGCTGC CGTGCGTGGC CCGAGGGGGT AATCCCTTAG CCACACTGCA GTGGCTGAAG 
AATGGCCAGC CGGTGTCCAC AGCGTGGGGC ACAGAGCACA CCCAGGCGGT GGCCCGCAGT 
GTGCTGGTGA TGACCGTGAG GCCAGAAGAC CATGGAGCGC AGCTCAGCTG CGAGGCCCAC 
AACAGCGTGT CTGCAGGGAC CCAGGAGCAC GGCATCACAC TGCAGGTCAC CTTTCCCCCT 
AGTGCCATTA TTATCTTGGG ATCTGCATCC CAGACTGAGA ACAAGAACGT GACACTCTCC 
TGTGTCAGCA AGTCCAGTCG CCCGCGGGTT CTGCTACGAT GGTGGCTGGG CTGGCGGCAG 
CTGCTGCCCA TGGAGGAGAC AGTCATGGAT GGACTGCATG GCGGTCACAT CTCCATGTCC 
AACCTGACAT TCCTGGCGCG GCGGGAGGAC AACGGTCTGA CCCTCACATG TGAGGCCTTC 
AGTGAAGCCT TCACCAAGGA GACCTTCAAG AAGTCGCTCA TCCTGAACGT AAAATATCCC 
GCCCAGAAAC TGTGGATTGA GGGTCCCCCA GAGGGCCAGA AGCTCCGGGC TGGGACCCGG 
GTGAGGCTGG TGTGTTTGGC TATCGGGGGC AACCCAGAGC CCTCCCTCAT GTGGTACAAG 
GACTCGCGCA CCGTGACCGA GTCGCGGCTG CCGCAGGAGT CGCGGCGCGT GCATCTCGGC 
AGCGTGGAGA AATCTGGGAG CACCTTCTCC CGAGAGCTGG TGCTGGTCAC AGGGCCGTCG 
GACAACCAGG CCAAGTTCAC GTGCAAGGCT GGACAGCTCA GCGCGTCCAC GCAGCTGGCG 
GTGCAGTTTC CCCCAACTAA CGTGACGATC CTGGCCAACG CATCCGCACT GCGCCCGGGA 
GACGCCTTAA ACTTGACATG CGTCAGCGTC AGCAGCAATC CGCCGGTCAA CTTGTCCTGG 
GACAAGGAAG GGGAGAGGCT GGAGGGCGTG GCCGCCCCAC CCCGGAGAGC CCCATTCAAA 
GGCTCCGCCG CCGCCAGGAG CGTCCTTCTG CAAGTGTCAT CCCGCGATCA TGGCCAGCGC 
GTGACCTGCC GCGCCCACAG CGCCGAGCTC CGCGAAACCG TGAGCTCCTT CTATCGCCTC 
AACGTACTGT ACCGTCCAGA GTTCCTGGGG GAGCAGGTGC TGGTGGTGAC CGCGGTGGAG 
CAGGGCGAGG CGTTGCTGCC CGTGTCCGTG TCCGCTAACC CCGCCCCCGA GGCCTTCAAC 
TGGACCTTCC GCGGCTATCG CCTCAGTCCA GCGGGCGGCC CCCGGCATCG CATCCTGTCC 
AGCGGGGCTC TGCATCTGTG GAATGTGACC CGCGCGGACG ACGGCCTCTA TCAGCTGCAC 
TGCCAGAACT CTGAGGGCAC CGCGGAAGCG CGGCTGCGGC TGGACGTGCA CTATGCTCCC 
ACCATCCGTG CCCTCCAGGA CCCCACTGAG GTGAACGTCG GGGGTTCTGT GGACATAGTC 
TGCACTGTCG ATGCCAATCC CATCCTCCCG GGCATGTTCA ACTGGGAGAG ACTGGGAGAA 
GATGAGGAGG ACCAGAGCCT GGATGACATG GAGAAGATAT CCAGGGGACC AACGGGGCGC 
CTGCGGATTC ACCATGCCAA ACTGGCCCAG GCTGGCGCTT ACCAGTGCAT TGTGGACAAT 
GGGGTGGCGC CTCCAGCACG ACGGCTGCTC CGTCTTGTTG TCAGATTTGC CCCCCAGGTG 
GAGCACCCCA CTCCCCTAAC TAAGGTGGCT GCAGCTGGAG ACAGCACCAG TTCTGCCACC 
CTCCACTGCC GTGCCCGAGG TGTCCCCAAC ATCGTTTTCA CTTGGACAAA AAACGGGGTC 
CCTCTGGATC TCCAAGATCC CAGGTACACG GAGCACACAT ACCACCAGGG TGGTGTCCAC 
AGCAGCCTCC TGACCATTGC CAACGTGTCT GCCGCCCAGG ATTACGCCCT CTTCACATGT 
ACAGCCACCA ACGCCCTTGG CTCGGACCAA ACCAACATTC AACTTGTCAG CATCAGCCGC 
CCTGACCCTC CATCAGGATT AAAGGTTGTG AGTCTGACCC CACACTCCGT GGGGCTGGAG 
TGGAAGCCTG GCTTTGATGG GGGCCTGCCA CAGAGGTTCT GCATCAGGTA TGAGGCCCTG 
GGGACTCCAG GGTTCCACTA TGTGGATGTC GTACCACCCC AGGCCACCAC CTTCACGCTG 
ACTGGTCTAC AGCCTTCTAC AAGATACAGG GTCTGGCTGC TGGCCAGTAA TGCCTTGGGG 
GACAGTGGAC TGGCTGACAA AGGGACCCAG CTTCCCATCA CTACCCCAGG TCTCCACCAG 
CCTTCTGGAG AACCTGAAGA CCAGCTGCCC ACAGAGCCAC CTTCAGGACC CTCGGGGCTG 
CCCCTGCTGC CTGTGCTGTT CGCTCTTGGG GGGCTTCTGC TCCTCTCCAA TGCCTCCTGT 
GTCGGGGGGG TCCTCTGGCA GCGGAGACTC AGGCGTCTTG CTGAGGGCAT CTCAGAGAAG 
ACAGAGGCAG GGTCGGAAGA GGACCGAGTC AGGAACGAAT ATGAGGAGAG CCAGTGGACA 
GGAGAGCGGG ACACTCAGAG CTCCACGGTC AGCACAACAG AGGCAGAGCC GTATTACCGC 
TCCCTGAGGG ACTTCAGCCC CCAGCTGCCC CCGACGCAGG AGGAGGTGTC TTATTCCCGA 
GGTTTCACAG GTGAAGATGA GGATATGGCC TTCCCTGGGC ACTTGTATGA TGAGGTAGAA 
AGAACGTACC CCCCGTCTGG AGCCTGGGGA CCCCTCTACG ATGAAGTGCA GATGGGACCC 
TGGGACCTCC ACTGGCCTGA AGACACATAT CAGGATCCAA GAGGAATCTA TGACCAGGTG 
GCCGGAGACT TGGACACTCT GGAACCCGAT TCTCTGCCCT TCGAGCTGAG GGGACATCTG 
GTGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Novel mutation in the nephrin gene of a Japanese patient with congenital nephrotic syndrome of the Finnish type.
Kidney international57(2)401-4(2000 Feb)
Aya K,Tanaka H,Seino Y

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NPHS1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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