FXYD2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	FXYD2
Entrez Gene ID	486
Full Name	FXYD domain containing ion transport regulator 2
Synonyms	ATP1G1,HOMG2
General protein information	Preferred Names FXYD domain containing ion transport regulator 2 Names sodium/potassium-transporting ATPase subunit gamma ATPase, Na+/K+ transporting, gamma 1 polypeptide Na(+)/K(+) ATPase subunit gamma sodium pump gamma chain
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 11 Map Location: 11q23.3
Summary	This gene encodes a member of the FXYD family of transmembrane proteins. This particular protein encodes the sodium/potassium-transporting ATPase subunit gamma. Mutations in this gene have been associated with Renal Hypomagnesemia-2. Alternatively spliced transcript variants have been described. Read-through transcripts have been observed between this locus and the upstream FXYD domain-containing ion transport regulator 6 (FXYD6, GeneID 53826) locus.[provided by RefSeq, Feb 2011].
Disorder MIM:	601814
Disorder Html:	Hypomagnesemia 2, renal, 154020 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_021603.3	NP_067614.1	sodium/potassium-transporting ATPase subunit gamma isoform 2
NM_001680.4	NP_001671.2	sodium/potassium-transporting ATPase subunit gamma isoform 1
NM_001680.5	NP_001671.2	sodium/potassium-transporting ATPase subunit gamma isoform 1
NM_021603.4	NP_067614.1	sodium/potassium-transporting ATPase subunit gamma isoform 2

Pathways from BioSystems

Homologies

Homo sapiens (human)	FXYD2	NP_067614.1
Pan troglodytes (chimpanzee)	FXYD2	XP_001158882.2
	FXYD2	XP_001092388.2
Rattus norvegicus (Norway rat)	Fxyd2	NP_059045.2
Canis lupus familiaris (dog)	FXYD2	NP_001239266.1
Bos taurus (cattle)	FXYD2	NP_776745.2

Gene Ontology
Bibliography

Related articles in PubMed

Targeting FXYD2 by cardiac glycosides potently blocks tumor growth in ovarian clear cell carcinoma.
Hsu IL, Chou CY, Wu YY, Wu JE, Liang CH, Tsai YT, Ke JY, Chen YL, Hsu KF, Hong TM
Oncotarget7(39)62925-62938(2016 Sep)

Recurrent FXYD2 p.Gly41Arg mutation in patients with isolated dominant hypomagnesaemia.
de Baaij JH, Dorresteijn EM, Hennekam EA, Kamsteeg EJ, Meijer R, Dahan K, Muller M, van den Dorpel MA, Bindels RJ, Hoenderop JG, Devuyst O, Knoers NV
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association30(6)952-7(2015 Jun)

Structure of the Na,K-ATPase regulatory protein FXYD2b in micelles: implications for membrane-water interfacial arginines.
Gong XM, Ding Y, Yu J, Yao Y, Marassi FM
Biochimica et biophysica acta1848(1 Pt B)299-306(2015 Jan)

FXYD2c plays a potential role in modulating Na(+)/K (+)-ATPase activity in HK-2 cells upon hypertonic challenge.
Chang CY, Tang CH, Hsin YH, Lai HT, Lee TH
The Journal of membrane biology247(1)93-105(2014 Jan)

Genomic organization of the human FXYD2 gene encoding the gamma subunit of the Na,K-ATPase.
Sweadner KJ, Wetzel RK, Arystarkhova E
Biochemical and biophysical research communications279(1)196-201(2000 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Recurrent FXYD2 p.Gly41Arg mutation is associated with isolated dominant hypomagnesaemia.
Title: Recurrent FXYD2 p.Gly41Arg mutation in patients with isolated dominant hypomagnesaemia.

FXYD2b could regulate the Na,K-ATPase by modulating the effective membrane surface electrostatics near the ion binding sites of the pump.
Title: Structure of the Na,K-ATPase regulatory protein FXYD2b in micelles: implications for membrane-water interfacial arginines.

PCBD1 (dimerization cofactor of HNF-1alpha) is coactivator of the HNF1B-mediated transcription necessary for fine tuning ATPase Na+/K+ transporting gamma 1 polypeptide (FXYD2) transcription in the distal convoluted tubule.
Title: Mutations in PCBD1 cause hypomagnesemia and renal magnesium wasting.

our findings suggested that FXYD2c played a role in regulation of NKA activity by enhancing the expression of NKA in HK-2 cells upon hypertonic challenge.
Title: FXYD2c plays a potential role in modulating Na(+)/K (+)-ATPase activity in HK-2 cells upon hypertonic challenge.

This is the first report demonstrating the potential utility of FXYD2 immunohistochemistry in the diagnosis of chromophobe renal cell carcinoma
Title: Expression of the Na+/K+-transporting ATPase gamma subunit FXYD2 in renal tumors.

The following FXYD2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the FXYD2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu23675	NM_021603.4 Latest version!	Homo sapiens FXYD domain containing ion transport regulator 2 (FXYD2), transcript variant b, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu24130	NM_001680.5 Latest version!	Homo sapiens FXYD domain containing ion transport regulator 2 (FXYD2), transcript variant a, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu24130	NM_001680.4	Homo sapiens FXYD domain containing ion transport regulator 2 (FXYD2), transcript variant a, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu23675	NM_021603.3	Homo sapiens FXYD domain containing ion transport regulator 2 (FXYD2), transcript variant b, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

FXYD2 ( NM_021603.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_067614.1 Homo sapiens FXYD domain containing ion transport regulator 2 (FXYD2), transcript variant b, mRNA.

Price & Availability↑

CloneID	OHu23675
Clone ID Related Accession (Same CDS sequence)	NM_021603.3 , NM_021603.4
Accession Version	NM_021603.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 195bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-06-23
Organism	Homo sapiens(human)
Product	sodium/potassium-transporting ATPase subunit gamma isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff in collaboration with Kathleen Sweadner. The reference sequence was derived from BC005302.1, AA309757.1, AF241236.1 and AA814197.1. This sequence is a reference standard in the RefSeqGene project. On May 21, 2008 this sequence version replaced NM_021603.2. Transcript Variant: This variant (b) contains an alternate 5' terminal exon compared to transcript variant a, resulting in a slightly shorter isoform (2) with a distinct N-terminus, compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC005302.1, ERR279839.6321.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1970526, SAMEA2145774 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGACAGGT GGTACCTGGG CGGCAGCCCC AAGGGGGACG TGGACCCGTT CTACTATGAC 
TATGAGACCG TTCGCAATGG GGGCCTGATC TTCGCTGGAC TGGCCTTCAT CGTGGGGCTC 
CTCATCCTCC TCAGCAGAAG ATTCCGCTGT GGGGGCAATA AGAAGCGCAG GCAAATCAAT 
GAAGATGAGC CGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_067614.1
CDS	80..274
Translation	MDRWYLGGSPKGDVDPFYYDYETVRNGGLIFAGLAFIVGLLILLSRRFRCGGNKKRRQINEDEP

Target ORF information:

RefSeq Version	NM_021603.3
Organism	Homo sapiens(human)
Definition	Homo sapiens FXYD domain containing ion transport regulator 2 (FXYD2), transcript variant b, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_021603.3

ORF Insert Sequence:

ATGGACAGGT GGTACCTGGG CGGCAGCCCC AAGGGGGACG TGGACCCGTT CTACTATGAC 
TATGAGACCG TTCGCAATGG GGGCCTGATC TTCGCTGGAC TGGCCTTCAT CGTGGGGCTC 
CTCATCCTCC TCAGCAGAAG ATTCCGCTGT GGGGGCAATA AGAAGCGCAG GCAAATCAAT 
GAAGATGAGC CGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

FXYD2 ( NM_021603.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_067614.1 Homo sapiens FXYD domain containing ion transport regulator 2 (FXYD2), transcript variant b, mRNA.

Price & Availability↑

CloneID	OHu23675
Clone ID Related Accession (Same CDS sequence)	NM_021603.3 , NM_021603.4
Accession Version	NM_021603.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 195bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-21
Organism	Homo sapiens(human)
Product	sodium/potassium-transporting ATPase subunit gamma isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff in collaboration with Kathleen Sweadner. The reference sequence was derived from BC005302.1, AA309757.1, AF241236.1, AA814197.1 and AP000757.4. This sequence is a reference standard in the RefSeqGene project. On May 31, 2019 this sequence version replaced NM_021603.3. Transcript Variant: This variant (b) contains an alternate 5' terminal exon compared to transcript variant a, resulting in a slightly shorter isoform (2) with a distinct N-terminus, compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: ERR279839.6321.1, BC005302.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1970526, SAMEA2145774 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGACAGGT GGTACCTGGG CGGCAGCCCC AAGGGGGACG TGGACCCGTT CTACTATGAC 
TATGAGACCG TTCGCAATGG GGGCCTGATC TTCGCTGGAC TGGCCTTCAT CGTGGGGCTC 
CTCATCCTCC TCAGCAGAAG ATTCCGCTGT GGGGGCAATA AGAAGCGCAG GCAAATCAAT 
GAAGATGAGC CGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_067614.1
CDS	77..271
Translation	MDRWYLGGSPKGDVDPFYYDYETVRNGGLIFAGLAFIVGLLILLSRRFRCGGNKKRRQINEDEP

Target ORF information:

RefSeq Version	NM_021603.4
Organism	Homo sapiens(human)
Definition	Homo sapiens FXYD domain containing ion transport regulator 2 (FXYD2), transcript variant b, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_021603.4

ORF Insert Sequence:

ATGGACAGGT GGTACCTGGG CGGCAGCCCC AAGGGGGACG TGGACCCGTT CTACTATGAC 
TATGAGACCG TTCGCAATGG GGGCCTGATC TTCGCTGGAC TGGCCTTCAT CGTGGGGCTC 
CTCATCCTCC TCAGCAGAAG ATTCCGCTGT GGGGGCAATA AGAAGCGCAG GCAAATCAAT 
GAAGATGAGC CGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

FXYD2 ( NM_001680.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_001671.2 Homo sapiens FXYD domain containing ion transport regulator 2 (FXYD2), transcript variant a, mRNA.

Price & Availability↑

CloneID	OHu24130
Clone ID Related Accession (Same CDS sequence)	NM_001680.4 , NM_001680.5
Accession Version	NM_001680.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 201bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-26
Organism	Homo sapiens(human)
Product	sodium/potassium-transporting ATPase subunit gamma isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff in collaboration with Kathleen Sweadner. The reference sequence was derived from BC013289.1, AF241236.1 and AA814197.1. On May 21, 2008 this sequence version replaced NM_001680.3. Transcript Variant: This variant (a) represents the most predominant transcript and encodes isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF241236.1, BX095407.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1970526, SAMEA2145774 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGACTGGGT TGTCGATGGA CGGTGGCGGC AGCCCCAAGG GGGACGTGGA CCCGTTCTAC 
TATGACTATG AGACCGTTCG CAATGGGGGC CTGATCTTCG CTGGACTGGC CTTCATCGTG 
GGGCTCCTCA TCCTCCTCAG CAGAAGATTC CGCTGTGGGG GCAATAAGAA GCGCAGGCAA 
ATCAATGAAG ATGAGCCGTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001671.2
CDS	67..267
Translation	MTGLSMDGGGSPKGDVDPFYYDYETVRNGGLIFAGLAFIVGLLILLSRRFRCGGNKKRRQINEDEP

Target ORF information:

RefSeq Version	NM_001680.4
Organism	Homo sapiens(human)
Definition	Homo sapiens FXYD domain containing ion transport regulator 2 (FXYD2), transcript variant a, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001680.4

ORF Insert Sequence:

ATGACTGGGT TGTCGATGGA CGGTGGCGGC AGCCCCAAGG GGGACGTGGA CCCGTTCTAC 
TATGACTATG AGACCGTTCG CAATGGGGGC CTGATCTTCG CTGGACTGGC CTTCATCGTG 
GGGCTCCTCA TCCTCCTCAG CAGAAGATTC CGCTGTGGGG GCAATAAGAA GCGCAGGCAA 
ATCAATGAAG ATGAGCCGTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

FXYD2 ( NM_001680.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_001671.2 Homo sapiens FXYD domain containing ion transport regulator 2 (FXYD2), transcript variant a, mRNA.

Price & Availability↑

CloneID	OHu24130
Clone ID Related Accession (Same CDS sequence)	NM_001680.4 , NM_001680.5
Accession Version	NM_001680.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 201bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-07-05
Organism	Homo sapiens(human)
Product	sodium/potassium-transporting ATPase subunit gamma isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff in collaboration with Kathleen Sweadner. The reference sequence was derived from BC013289.1, AF241236.1, AA814197.1 and AP000757.4. On Nov 22, 2018 this sequence version replaced NM_001680.4. Transcript Variant: This variant (a) represents the most predominant transcript and encodes isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BX095407.1, AF241236.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1970526, SAMEA2145774 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000292079.7/ ENSP00000292079.2 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGACTGGGT TGTCGATGGA CGGTGGCGGC AGCCCCAAGG GGGACGTGGA CCCGTTCTAC 
TATGACTATG AGACCGTTCG CAATGGGGGC CTGATCTTCG CTGGACTGGC CTTCATCGTG 
GGGCTCCTCA TCCTCCTCAG CAGAAGATTC CGCTGTGGGG GCAATAAGAA GCGCAGGCAA 
ATCAATGAAG ATGAGCCGTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001671.2
CDS	67..267
Translation	MTGLSMDGGGSPKGDVDPFYYDYETVRNGGLIFAGLAFIVGLLILLSRRFRCGGNKKRRQINEDEP

Target ORF information:

RefSeq Version	NM_001680.5
Organism	Homo sapiens(human)
Definition	Homo sapiens FXYD domain containing ion transport regulator 2 (FXYD2), transcript variant a, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001680.5

ORF Insert Sequence:

ATGACTGGGT TGTCGATGGA CGGTGGCGGC AGCCCCAAGG GGGACGTGGA CCCGTTCTAC 
TATGACTATG AGACCGTTCG CAATGGGGGC CTGATCTTCG CTGGACTGGC CTTCATCGTG 
GGGCTCCTCA TCCTCCTCAG CAGAAGATTC CGCTGTGGGG GCAATAAGAA GCGCAGGCAA 
ATCAATGAAG ATGAGCCGTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Targeting FXYD2 by cardiac glycosides potently blocks tumor growth in ovarian clear cell carcinoma.
Oncotarget7(39)62925-62938(2016 Sep)
Hsu IL,Chou CY,Wu YY,Wu JE,Liang CH,Tsai YT,Ke JY,Chen YL,Hsu KF,Hong TM

Recurrent FXYD2 p.Gly41Arg mutation in patients with isolated dominant hypomagnesaemia.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association30(6)952-7(2015 Jun)
de Baaij JH,Dorresteijn EM,Hennekam EA,Kamsteeg EJ,Meijer R,Dahan K,Muller M,van den Dorpel MA,Bindels RJ,Hoenderop JG,Devuyst O,Knoers NV

Structure of the Na,K-ATPase regulatory protein FXYD2b in micelles: implications for membrane-water interfacial arginines.
Biochimica et biophysica acta1848(1 Pt B)299-306(2015 Jan)
Gong XM,Ding Y,Yu J,Yao Y,Marassi FM

FXYD2c plays a potential role in modulating Na(+)/K (+)-ATPase activity in HK-2 cells upon hypertonic challenge.
The Journal of membrane biology247(1)93-105(2014 Jan)
Chang CY,Tang CH,Hsin YH,Lai HT,Lee TH

Genomic organization of the human FXYD2 gene encoding the gamma subunit of the Na,K-ATPase.
Biochemical and biophysical research communications279(1)196-201(2000 Dec)
Sweadner KJ,Wetzel RK,Arystarkhova E

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FXYD2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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