NPY cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	NPY
Entrez Gene ID	4852
Full Name	neuropeptide Y
Synonyms	PYY4
General protein information	Preferred Names neuropeptide Y Names pro-neuropeptide Y prepro-neuropeptide Y
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 7 Map Location: 7p15.3
Summary	This gene encodes a neuropeptide that is widely expressed in the central nervous system and influences many physiological processes, including cortical excitability, stress response, food intake, circadian rhythms, and cardiovascular function. The neuropeptide functions through G protein-coupled receptors to inhibit adenylyl cyclase, activate mitogen-activated protein kinase (MAPK), regulate intracellular calcium levels, and activate potassium channels. A polymorphism in this gene resulting in a change of leucine 7 to proline in the signal peptide is associated with elevated cholesterol levels, higher alcohol consumption, and may be a risk factor for various metabolic and cardiovascular diseases. The protein also exhibits antimicrobial activity against bacteria and fungi. [provided by RefSeq, Oct 2014].
Disorder MIM:	162640

mRNA and Protein(s)

mRNA	Protein	Name
NM_000905.3	NP_000896.1	pro-neuropeptide Y preproprotein
NM_000905.4	NP_000896.1	pro-neuropeptide Y preproprotein

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Npy	NP_075945.1
Homo sapiens (human)	NPY	NP_000896.1
Rattus norvegicus (Norway rat)	LOC100912228	XP_003749793.1
Gallus gallus (chicken)	NPY	NP_990804.1
Danio rerio (zebrafish)	npy	NP_571149.1
Canis lupus familiaris (dog)	NPY	XP_005628694.1
Rattus norvegicus (Norway rat)	Npy	NP_036746.1
Xenopus tropicalis (tropical clawed frog)	npy	NP_001072530.1
Pan troglodytes (chimpanzee)	NPY	XP_001159094.1
	NPY	NP_001027986.1
Bos taurus (cattle)	NPY	NP_001014845.1

Gene Ontology
Bibliography

Related articles in PubMed

Association study of arcuate nucleus neuropeptide Y neuron receptor gene variation and serum NPY levels in clozapine treated patients with schizophrenia.
Klemettil? JP, Kampman O, Solismaa A, Lyytik?inen LP, Sepp?l? N, Viikki M, H?m?l?inen M, Moilanen E, Mononen N, Lehtim?ki T, Leinonen E
European psychiatry : the journal of the Association of European Psychiatrists4013-19(2017 Feb)

Multifaces of neuropeptide Y in the brain--neuroprotection, neurogenesis and neuroinflammation.
Malva JO, Xapelli S, Baptista S, Valero J, Agasse F, Ferreira R, Silva AP
Neuropeptides46(6)299-308(2012 Dec)

Neuropeptide Y: its multiple effects in the CNS and potential clinical significance.
Benarroch EE
Neurology72(11)1016-20(2009 Mar)

Antimicrobial activity of neuropeptides against a range of micro-organisms from skin, oral, respiratory and gastrointestinal tract sites.
El Karim IA, Linden GJ, Orr DF, Lundy FT
Journal of neuroimmunology200(1-2)11-6(2008 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

genetic variation in NPY and NPY2R is at low frequency and thus does not make a major contribution to the obese phenotype in the general population
Title: Evaluation of a Role for NPY and NPY2R in the Pathogenesis of Obesity by Mutation and Copy Number Variation Analysis in Obese Children and Adolescents.

Genetic risk score (GRSNPY) analysis found twelve significant (P<0.05) serum NPY concentration related SNPs among alpha7 nicotinic acetylcholine receptor gene CHRNA7, insulin receptor gene INSR, leptin receptor gene LEPR, glucocorticoid receptor (GR) gene NR3C1, and NPY gene. However, after permutation test of gene score the predictive value of GRSNPY remained non-significant (P=0.078). CONCLUSIONS: Serum NPY level ...
Title: Association study of arcuate nucleus neuropeptide Y neuron receptor gene variation and serum NPY levels in clozapine treated patients with schizophrenia.

The CT genotype of rs5574 and the GT genotype of rs17149106 are significantly associated with prevalent asthma.
Title: Neuropeptide Y associated with asthma in young adults.

Neuropeptide Y is the best dipeptidyl peptidase 4 (DPP4)-substrate in blood, being truncated by soluble and membrane DPP4, respectively. The decline of soluble DPP4 in acute depression could be reversed upon anti-depressive treatment.
Title: Identifying neuropeptide Y (NPY) as the main stress-related substrate of dipeptidyl peptidase 4 (DPP4) in blood circulation.

NPY plays important roles in the pathogenesis and pathophysiology of pituitary adenomas, as shown in this clinical study.
Title: Expression of Neuropeptide Y and Its Relationship with Molecular and Morphological Changes in Human Pituitary Adenomas.

The following NPY gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the NPY cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu17996	NM_000905.4 Latest version!	Homo sapiens neuropeptide Y (NPY), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
View Old Accession Versions >>
OHu17996	NM_000905.3	Homo sapiens neuropeptide Y (NPY), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
Hide Old Accession Versions >>

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

NPY ( NM_000905.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_000896.1 Homo sapiens neuropeptide Y (NPY), mRNA.

Price & Availability↑

CloneID	OHu17996
Clone ID Related Accession (Same CDS sequence)	NM_000905.3 , NM_000905.4
Accession Version	NM_000905.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 294bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-28
Organism	Homo sapiens(human)
Product	pro-neuropeptide Y preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC029497.1, K01911.1 and AI198311.1. This sequence is a reference standard in the RefSeqGene project. On Nov 19, 2009 this sequence version replaced NM_000905.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC029497.1, BI457963.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## Protein has antimicrobial activity :: PMID: 9756788 ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCTAGGTA ACAAGCGACT GGGGCTGTCC GGACTGACCC TCGCCCTGTC CCTGCTCGTG 
TGCCTGGGTG CGCTGGCCGA GGCGTACCCC TCCAAGCCGG ACAACCCGGG CGAGGACGCA 
CCAGCGGAGG ACATGGCCAG ATACTACTCG GCGCTGCGAC ACTACATCAA CCTCATCACC 
AGGCAGAGAT ATGGAAAACG ATCCAGCCCA GAGACACTGA TTTCAGACCT CTTGATGAGA 
GAAAGCACAG AAAATGTTCC CAGAACTCGG CTTGAAGACC CTGCAATGTG GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000896.1
CDS	89..382
Translation	MLGNKRLGLSGLTLALSLLVCLGALAEAYPSKPDNPGEDAPAEDMARYYSALRHYINLITRQRYGKRSSPETLISDLLMRESTENVPRTRLEDPAMW

Target ORF information:

RefSeq Version	NM_000905.3
Organism	Homo sapiens(human)
Definition	Homo sapiens neuropeptide Y (NPY), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000905.3

ORF Insert Sequence:

ATGCTAGGTA ACAAGCGACT GGGGCTGTCC GGACTGACCC TCGCCCTGTC CCTGCTCGTG 
TGCCTGGGTG CGCTGGCCGA GGCGTACCCC TCCAAGCCGG ACAACCCGGG CGAGGACGCA 
CCAGCGGAGG ACATGGCCAG ATACTACTCG GCGCTGCGAC ACTACATCAA CCTCATCACC 
AGGCAGAGAT ATGGAAAACG ATCCAGCCCA GAGACACTGA TTTCAGACCT CTTGATGAGA 
GAAAGCACAG AAAATGTTCC CAGAACTCGG CTTGAAGACC CTGCAATGTG GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

NPY ( NM_000905.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_000896.1 Homo sapiens neuropeptide Y (NPY), mRNA.

Price & Availability↑

CloneID	OHu17996
Clone ID Related Accession (Same CDS sequence)	NM_000905.3 , NM_000905.4
Accession Version	NM_000905.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 294bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-25
Organism	Homo sapiens(human)
Product	pro-neuropeptide Y preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from K01911.1 and AI198311.1. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_000905.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: DA330523.1, BC029497.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000242152.7/ ENSP00000242152.2 Protein has antimicrobial activity :: PMID: 9756788 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCTAGGTA ACAAGCGACT GGGGCTGTCC GGACTGACCC TCGCCCTGTC CCTGCTCGTG 
TGCCTGGGTG CGCTGGCCGA GGCGTACCCC TCCAAGCCGG ACAACCCGGG CGAGGACGCA 
CCAGCGGAGG ACATGGCCAG ATACTACTCG GCGCTGCGAC ACTACATCAA CCTCATCACC 
AGGCAGAGAT ATGGAAAACG ATCCAGCCCA GAGACACTGA TTTCAGACCT CTTGATGAGA 
GAAAGCACAG AAAATGTTCC CAGAACTCGG CTTGAAGACC CTGCAATGTG GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000896.1
CDS	87..380
Translation	MLGNKRLGLSGLTLALSLLVCLGALAEAYPSKPDNPGEDAPAEDMARYYSALRHYINLITRQRYGKRSSPETLISDLLMRESTENVPRTRLEDPAMW

Target ORF information:

RefSeq Version	NM_000905.4
Organism	Homo sapiens(human)
Definition	Homo sapiens neuropeptide Y (NPY), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000905.4

ORF Insert Sequence:

ATGCTAGGTA ACAAGCGACT GGGGCTGTCC GGACTGACCC TCGCCCTGTC CCTGCTCGTG 
TGCCTGGGTG CGCTGGCCGA GGCGTACCCC TCCAAGCCGG ACAACCCGGG CGAGGACGCA 
CCAGCGGAGG ACATGGCCAG ATACTACTCG GCGCTGCGAC ACTACATCAA CCTCATCACC 
AGGCAGAGAT ATGGAAAACG ATCCAGCCCA GAGACACTGA TTTCAGACCT CTTGATGAGA 
GAAAGCACAG AAAATGTTCC CAGAACTCGG CTTGAAGACC CTGCAATGTG GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Association study of arcuate nucleus neuropeptide Y neuron receptor gene variation and serum NPY levels in clozapine treated patients with schizophrenia.
European psychiatry : the journal of the Association of European Psychiatrists4013-19(2017 Feb)
Klemettil? JP,Kampman O,Solismaa A,Lyytik?inen LP,Sepp?l? N,Viikki M,H?m?l?inen M,Moilanen E,Mononen N,Lehtim?ki T,Leinonen E

Multifaces of neuropeptide Y in the brain--neuroprotection, neurogenesis and neuroinflammation.
Neuropeptides46(6)299-308(2012 Dec)
Malva JO,Xapelli S,Baptista S,Valero J,Agasse F,Ferreira R,Silva AP

Neuropeptide Y: its multiple effects in the CNS and potential clinical significance.
Neurology72(11)1016-20(2009 Mar)
Benarroch EE

Antimicrobial activity of neuropeptides against a range of micro-organisms from skin, oral, respiratory and gastrointestinal tract sites.
Journal of neuroimmunology200(1-2)11-6(2008 Aug)
El Karim IA,Linden GJ,Orr DF,Lundy FT

- Most Popular Services
  - 人工遺伝子合成& DNA合成-納期保証
- Services & Products

見積依頼

Eメール

japanmarket@genscript.com

電話

03-6811-6572

FAX

03-6811-6573
050-3174-7589(受注専用)

オンラインフォーム

オンライン注文

NPY cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Most Popular Services

Services & Products

見積依頼

Eメール

電話

FAX

オンラインフォーム

サポート

会社情報

サポート

会社情報