NMB cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	NMB
Entrez Gene ID	4828
Full Name	neuromedin B
General protein information	Preferred Names neuromedin B Names neuromedin-B Neuromedin-B-32 neuromedin-beta
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 15 Map Location: 15q25.2
Summary	This gene encodes a member of the bombesin-like family of neuropeptides, which negatively regulate eating behavior. The encoded protein may regulate colonic smooth muscle contraction through binding to its cognate receptor, the neuromedin B receptor (NMBR). Polymorphisms of this gene may be associated with hunger, weight gain and obesity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015].
Disorder MIM:	162340

mRNA and Protein(s)

mRNA	Protein	Name
NM_021077.3	NP_066563.2	neuromedin-B isoform 1 preproprotein
NM_205858.1	NP_995580.1	neuromedin-B isoform 2 preproprotein
XM_017022239.1	XP_016877728.1	neuromedin-B isoform X1
NM_021077.4	NP_066563.2	neuromedin-B isoform 1 preproprotein
NM_205858.2	NP_995580.1	neuromedin-B isoform 2 preproprotein

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	NMB	XP_536200.1
Homo sapiens (human)	NMB	NP_066563.2
Rattus norvegicus (Norway rat)	Nmb	NP_001102619.1
Bos taurus (cattle)	NMB	NP_001068738.1
Pan troglodytes (chimpanzee)	NMB	XP_001162171.1
Mus musculus (house mouse)	Nmb	NP_080799.1

Gene Ontology
Bibliography

Related articles in PubMed

Effects of MC4R, FTO, and NMB gene variants to obesity, physical activity, and eating behavior phenotypes.
Kirac D, Kasimay Cakir O, Avcilar T, Deyneli O, Kurtel H, Yazici D, Kaspar EC, Celik N, Guney AI
IUBMB life68(10)806-16(2016 10)

Itch-associated peptides: RNA-Seq and bioinformatic analysis of natriuretic precursor peptide B and gastrin releasing peptide in dorsal root and trigeminal ganglia, and the spinal cord.
Goswami SC, Thierry-Mieg D, Thierry-Mieg J, Mishra S, Hoon MA, Mannes AJ, Iadarola MJ
Molecular pain1044(2014 Aug)

Anti-EGFR therapy combined with neuromedin B receptor blockade induces the death of DAOY medulloblastoma cells.
Jaeger M, N?r C, de Farias CB, Abujamra AL, Schwartsmann G, Brunetto AL, Roesler R
Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery29(12)2145-50(2013 Dec)

Functional bombesin receptors in urinary tract of rats and human but not of pigs and mice, an in vitro study.
Kullmann FA, McKenna D, Wells GI, Thor KB
Neuropeptides47(5)305-13(2013 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Genetic clues to the mechanism by which MC4R, FTO, and NMB influences changes in BMI and obesity.
Title: Effects of MC4R, FTO, and NMB gene variants to obesity, physical activity, and eating behavior phenotypes.

Rs2292462 was associated with left ventricular hypertrophy in type 2 diabetic patients.
Title: Genetic variants predicting left ventricular hypertrophy in a diabetic population: a Go-DARTS study including meta-analysis.

There was no association between eating behaviour traits, or anthropometric variables, and NMB p.P73T polymorphism.
Title: Effects of neuromedin-? on caloric compensation, eating behaviours and habitual food intake.

TT genotype of the NMB rs3809508 polymorphism was associated with a higher risk of obesity and moreover, the effects of this polymorphism on anthropometric values were influenced by the maternal educational level.
Title: Influence of maternal educational level on the association between the rs3809508 neuromedin B gene polymorphism and the risk of obesity in the HELENA study.

No significant differences in the genotype distribution were demonstrated between normal weight and overweight/obese subjects
Title: Neuromedin beta: P73T polymorphism in overweight and obese subjects.

The following NMB gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the NMB cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu29226	NM_205858.2 Latest version!	Homo sapiens neuromedin B (NMB), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu03611	NM_021077.4 Latest version!	Homo sapiens neuromedin B (NMB), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu85445	XM_017022239.1 Latest version!	Homo sapiens neuromedin B (NMB), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
View Old Accession Versions >>
OHu03611	NM_021077.3	Homo sapiens neuromedin B (NMB), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu29226	NM_205858.1	Homo sapiens neuromedin B (NMB), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

NMB ( NM_205858.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_995580.1 Homo sapiens neuromedin B (NMB), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu29226
Clone ID Related Accession (Same CDS sequence)	NM_205858.1 , NM_205858.2
Accession Version	NM_205858.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 465bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-13
Organism	Homo sapiens(human)
Product	neuromedin-B isoform 2 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BI858080.1 and BC007407.2. On May 31, 2019 this sequence version replaced NM_205858.1. Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. It encodes isoform 2, which has a longer and distinct C-terminus, compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BQ897104.1, BC007407.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCCCGGC GGGCGGGGGG CGCTCGGATG TTCGGCAGCC TCCTGCTCTT CGCCCTGCTC 
GCTGCCGGCG TCGCCCCGCT CAGCTGGGAT CTCCCGGAGC CCCGCAGCCG AGCCAGCAAG 
ATCCGAGTGC ACTCGCGAGG CAACCTCTGG GCCACCGGTC ACTTCATGGG CAAGAAGAGT 
CTGGAGCCTT CCAGCCCATC CCCATTGGGG ACAGCTCCCC ACACCTCCCT GAGGGACCAG 
CGACTGCAGC TGAGTCATGA TCTGCTCGGA ATCCTCCTGC TAAAGAAGGC TCTGGGCGTG 
AGCCTCAGCC GCCCCGCACC CCAAATCCAG GAGGCTGCTG GTACAAATAC TGCAGAAATG 
ACACCAATAA TGGGGCAGAC ACAACAGCGT GGCTTAGATT GTGCCCACCC AGGGAAGGTG 
CTGAATGGGA CCCTGTTGAT GGCCCCATCT GGATGTAAAT CCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_995580.1
CDS	48..512
Translation	MARRAGGARMFGSLLLFALLAAGVAPLSWDLPEPRSRASKIRVHSRGNLWATGHFMGKKSLEPSSPSPLGTAPHTSLRDQRLQLSHDLLGILLLKKALGVSLSRPAPQIQEAAGTNTAEMTPIMGQTQQRGLDCAHPGKVLNGTLLMAPSGCKS

Target ORF information:

RefSeq Version	NM_205858.2
Organism	Homo sapiens(human)
Definition	Homo sapiens neuromedin B (NMB), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_205858.2

ORF Insert Sequence:

ATGGCCCGGC GGGCGGGGGG CGCTCGGATG TTCGGCAGCC TCCTGCTCTT CGCCCTGCTC 
GCTGCCGGCG TCGCCCCGCT CAGCTGGGAT CTCCCGGAGC CCCGCAGCCG AGCCAGCAAG 
ATCCGAGTGC ACTCGCGAGG CAACCTCTGG GCCACCGGTC ACTTCATGGG CAAGAAGAGT 
CTGGAGCCTT CCAGCCCATC CCCATTGGGG ACAGCTCCCC ACACCTCCCT GAGGGACCAG 
CGACTGCAGC TGAGTCATGA TCTGCTCGGA ATCCTCCTGC TAAAGAAGGC TCTGGGCGTG 
AGCCTCAGCC GCCCCGCACC CCAAATCCAG GAGGCTGCTG GTACAAATAC TGCAGAAATG 
ACACCAATAA TGGGGCAGAC ACAACAGCGT GGCTTAGATT GTGCCCACCC AGGGAAGGTG 
CTGAATGGGA CCCTGTTGAT GGCCCCATCT GGATGTAAAT CCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

NMB ( NM_021077.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_066563.2 Homo sapiens neuromedin B (NMB), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu03611
Clone ID Related Accession (Same CDS sequence)	NM_021077.3 , NM_021077.4
Accession Version	NM_021077.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 366bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-26
Organism	Homo sapiens(human)
Product	neuromedin-B isoform 1 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BI962836.1, BC007431.2, BI858080.1 and BC008603.1. On Mar 17, 2004 this sequence version replaced NM_021077.2. Transcript Variant: This variant (1) represents the longer transcript but encodes the shorter isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163657.299696.1, BI858080.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2157437 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCCCGGC GGGCGGGGGG CGCTCGGATG TTCGGCAGCC TCCTGCTCTT CGCCCTGCTC 
GCTGCCGGCG TCGCCCCGCT CAGCTGGGAT CTCCCGGAGC CCCGCAGCCG AGCCAGCAAG 
ATCCGAGTGC ACTCGCGAGG CAACCTCTGG GCCACCGGTC ACTTCATGGG CAAGAAGAGT 
CTGGAGCCTT CCAGCCCATC CCCATTGGGG ACAGCTCCCC ACACCTCCCT GAGGGACCAG 
CGACTGCAGC TGAGTCATGA TCTGCTCGGA ATCCTCCTGC TAAAGAAGGC TCTGGGCGTG 
AGCCTCAGCC GCCCCGCACC CCAAATCCAG TACAGGAGGC TGCTGGTACA AATACTGCAG 
AAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_066563.2
CDS	420..785
Translation	MARRAGGARMFGSLLLFALLAAGVAPLSWDLPEPRSRASKIRVHSRGNLWATGHFMGKKSLEPSSPSPLGTAPHTSLRDQRLQLSHDLLGILLLKKALGVSLSRPAPQIQYRRLLVQILQK

Target ORF information:

RefSeq Version	NM_021077.3
Organism	Homo sapiens(human)
Definition	Homo sapiens neuromedin B (NMB), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_021077.3

ORF Insert Sequence:

ATGGCCCGGC GGGCGGGGGG CGCTCGGATG TTCGGCAGCC TCCTGCTCTT CGCCCTGCTC 
GCTGCCGGCG TCGCCCCGCT CAGCTGGGAT CTCCCGGAGC CCCGCAGCCG AGCCAGCAAG 
ATCCGAGTGC ACTCGCGAGG CAACCTCTGG GCCACCGGTC ACTTCATGGG CAAGAAGAGT 
CTGGAGCCTT CCAGCCCATC CCCATTGGGG ACAGCTCCCC ACACCTCCCT GAGGGACCAG 
CGACTGCAGC TGAGTCATGA TCTGCTCGGA ATCCTCCTGC TAAAGAAGGC TCTGGGCGTG 
AGCCTCAGCC GCCCCGCACC CCAAATCCAG TACAGGAGGC TGCTGGTACA AATACTGCAG 
AAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

NMB ( NM_021077.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_066563.2 Homo sapiens neuromedin B (NMB), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu03611
Clone ID Related Accession (Same CDS sequence)	NM_021077.3 , NM_021077.4
Accession Version	NM_021077.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 366bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-13
Organism	Homo sapiens(human)
Product	neuromedin-B isoform 1 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BI858080.1, BC008603.1 and BC007431.2. On Nov 23, 2018 this sequence version replaced NM_021077.3. Transcript Variant: This variant (1) represents the longer transcript but encodes the shorter isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: W46216.1, SRR1163655.354772.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2157437 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000360476.8/ ENSP00000353664.3 RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCCCGGC GGGCGGGGGG CGCTCGGATG TTCGGCAGCC TCCTGCTCTT CGCCCTGCTC 
GCTGCCGGCG TCGCCCCGCT CAGCTGGGAT CTCCCGGAGC CCCGCAGCCG AGCCAGCAAG 
ATCCGAGTGC ACTCGCGAGG CAACCTCTGG GCCACCGGTC ACTTCATGGG CAAGAAGAGT 
CTGGAGCCTT CCAGCCCATC CCCATTGGGG ACAGCTCCCC ACACCTCCCT GAGGGACCAG 
CGACTGCAGC TGAGTCATGA TCTGCTCGGA ATCCTCCTGC TAAAGAAGGC TCTGGGCGTG 
AGCCTCAGCC GCCCCGCACC CCAAATCCAG TACAGGAGGC TGCTGGTACA AATACTGCAG 
AAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_066563.2
CDS	48..413
Translation	MARRAGGARMFGSLLLFALLAAGVAPLSWDLPEPRSRASKIRVHSRGNLWATGHFMGKKSLEPSSPSPLGTAPHTSLRDQRLQLSHDLLGILLLKKALGVSLSRPAPQIQYRRLLVQILQK

Target ORF information:

RefSeq Version	NM_021077.4
Organism	Homo sapiens(human)
Definition	Homo sapiens neuromedin B (NMB), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_021077.4

ORF Insert Sequence:

ATGGCCCGGC GGGCGGGGGG CGCTCGGATG TTCGGCAGCC TCCTGCTCTT CGCCCTGCTC 
GCTGCCGGCG TCGCCCCGCT CAGCTGGGAT CTCCCGGAGC CCCGCAGCCG AGCCAGCAAG 
ATCCGAGTGC ACTCGCGAGG CAACCTCTGG GCCACCGGTC ACTTCATGGG CAAGAAGAGT 
CTGGAGCCTT CCAGCCCATC CCCATTGGGG ACAGCTCCCC ACACCTCCCT GAGGGACCAG 
CGACTGCAGC TGAGTCATGA TCTGCTCGGA ATCCTCCTGC TAAAGAAGGC TCTGGGCGTG 
AGCCTCAGCC GCCCCGCACC CCAAATCCAG TACAGGAGGC TGCTGGTACA AATACTGCAG 
AAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

NMB ( NM_205858.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_995580.1 Homo sapiens neuromedin B (NMB), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu29226
Clone ID Related Accession (Same CDS sequence)	NM_205858.1 , NM_205858.2
Accession Version	NM_205858.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 465bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-15
Organism	Homo sapiens(human)
Product	neuromedin-B isoform 2 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BI962836.1, BC007431.2, BI858080.1 and BC007407.2. Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. It encodes isoform 2, which has a longer and distinct C-terminus, compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC007407.2, ERR279849.9620.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCCCGGC GGGCGGGGGG CGCTCGGATG TTCGGCAGCC TCCTGCTCTT CGCCCTGCTC 
GCTGCCGGCG TCGCCCCGCT CAGCTGGGAT CTCCCGGAGC CCCGCAGCCG AGCCAGCAAG 
ATCCGAGTGC ACTCGCGAGG CAACCTCTGG GCCACCGGTC ACTTCATGGG CAAGAAGAGT 
CTGGAGCCTT CCAGCCCATC CCCATTGGGG ACAGCTCCCC ACACCTCCCT GAGGGACCAG 
CGACTGCAGC TGAGTCATGA TCTGCTCGGA ATCCTCCTGC TAAAGAAGGC TCTGGGCGTG 
AGCCTCAGCC GCCCCGCACC CCAAATCCAG GAGGCTGCTG GTACAAATAC TGCAGAAATG 
ACACCAATAA TGGGGCAGAC ACAACAGCGT GGCTTAGATT GTGCCCACCC AGGGAAGGTG 
CTGAATGGGA CCCTGTTGAT GGCCCCATCT GGATGTAAAT CCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_995580.1
CDS	420..884
Translation	MARRAGGARMFGSLLLFALLAAGVAPLSWDLPEPRSRASKIRVHSRGNLWATGHFMGKKSLEPSSPSPLGTAPHTSLRDQRLQLSHDLLGILLLKKALGVSLSRPAPQIQEAAGTNTAEMTPIMGQTQQRGLDCAHPGKVLNGTLLMAPSGCKS

Target ORF information:

RefSeq Version	NM_205858.1
Organism	Homo sapiens(human)
Definition	Homo sapiens neuromedin B (NMB), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_205858.1

ORF Insert Sequence:

ATGGCCCGGC GGGCGGGGGG CGCTCGGATG TTCGGCAGCC TCCTGCTCTT CGCCCTGCTC 
GCTGCCGGCG TCGCCCCGCT CAGCTGGGAT CTCCCGGAGC CCCGCAGCCG AGCCAGCAAG 
ATCCGAGTGC ACTCGCGAGG CAACCTCTGG GCCACCGGTC ACTTCATGGG CAAGAAGAGT 
CTGGAGCCTT CCAGCCCATC CCCATTGGGG ACAGCTCCCC ACACCTCCCT GAGGGACCAG 
CGACTGCAGC TGAGTCATGA TCTGCTCGGA ATCCTCCTGC TAAAGAAGGC TCTGGGCGTG 
AGCCTCAGCC GCCCCGCACC CCAAATCCAG GAGGCTGCTG GTACAAATAC TGCAGAAATG 
ACACCAATAA TGGGGCAGAC ACAACAGCGT GGCTTAGATT GTGCCCACCC AGGGAAGGTG 
CTGAATGGGA CCCTGTTGAT GGCCCCATCT GGATGTAAAT CCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

NMB ( XM_017022239.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016877728.1 Homo sapiens neuromedin B (NMB), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu85445
Clone ID Related Accession (Same CDS sequence)	XM_017022239.1
Accession Version	XM_017022239.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 438bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	neuromedin-B isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000015.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCCCGGC GGGCGGGGGG CGCTCGGATG TTCGGCAGCC TCCTGCTCTT CGCCCTGCTC 
GCTGCCGGCG TCGCCCCGCT CAGCTGGGAT CTCCCGGAGC CCCGCAGCCG AGCCAGCAAG 
ATCCGAGTGC ACTCGCGAGG CAACCTCTGG GCCACCGGCG CCTCTTCACT CTCCACTTCC 
TACCCTGCCC TTTTTCGTCC CTTGTCCAAG CAGCCCACAC AACTAGCAGA GTTTCTCCCT 
GGCCCTGGAC CATCCCACCT TCCTGCCAGC TGTGCCATCC TCTCTACCTG TTCAGGAAAA 
GCTGAGGGAG CAGGCTTTGC CACCACCCAG ACACCTTTGT GGCTCCTTGG TGAGGTGGAA 
GCACCAAGAG GAGGAAGGTT AAGTGTCTTC CCGCTACAAG AACGGAAACG TGGGAGAGAT 
GAGGAACTTT TCCTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016877728.1
CDS	460..897
Translation	MARRAGGARMFGSLLLFALLAAGVAPLSWDLPEPRSRASKIRVHSRGNLWATGASSLSTSYPALFRPLSKQPTQLAEFLPGPGPSHLPASCAILSTCSGKAEGAGFATTQTPLWLLGEVEAPRGGRLSVFPLQERKRGRDEELFL

Target ORF information:

RefSeq Version	XM_017022239.1
Organism	Homo sapiens(human)
Definition	Homo sapiens neuromedin B (NMB), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017022239.1

ORF Insert Sequence:

ATGGCCCGGC GGGCGGGGGG CGCTCGGATG TTCGGCAGCC TCCTGCTCTT CGCCCTGCTC 
GCTGCCGGCG TCGCCCCGCT CAGCTGGGAT CTCCCGGAGC CCCGCAGCCG AGCCAGCAAG 
ATCCGAGTGC ACTCGCGAGG CAACCTCTGG GCCACCGGCG CCTCTTCACT CTCCACTTCC 
TACCCTGCCC TTTTTCGTCC CTTGTCCAAG CAGCCCACAC AACTAGCAGA GTTTCTCCCT 
GGCCCTGGAC CATCCCACCT TCCTGCCAGC TGTGCCATCC TCTCTACCTG TTCAGGAAAA 
GCTGAGGGAG CAGGCTTTGC CACCACCCAG ACACCTTTGT GGCTCCTTGG TGAGGTGGAA 
GCACCAAGAG GAGGAAGGTT AAGTGTCTTC CCGCTACAAG AACGGAAACG TGGGAGAGAT 
GAGGAACTTT TCCTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Effects of MC4R, FTO, and NMB gene variants to obesity, physical activity, and eating behavior phenotypes.
IUBMB life68(10)806-16(2016 10)
Kirac D,Kasimay Cakir O,Avcilar T,Deyneli O,Kurtel H,Yazici D,Kaspar EC,Celik N,Guney AI

Itch-associated peptides: RNA-Seq and bioinformatic analysis of natriuretic precursor peptide B and gastrin releasing peptide in dorsal root and trigeminal ganglia, and the spinal cord.
Molecular pain1044(2014 Aug)
Goswami SC,Thierry-Mieg D,Thierry-Mieg J,Mishra S,Hoon MA,Mannes AJ,Iadarola MJ

Anti-EGFR therapy combined with neuromedin B receptor blockade induces the death of DAOY medulloblastoma cells.
Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery29(12)2145-50(2013 Dec)
Jaeger M,N?r C,de Farias CB,Abujamra AL,Schwartsmann G,Brunetto AL,Roesler R

Functional bombesin receptors in urinary tract of rats and human but not of pigs and mice, an in vitro study.
Neuropeptides47(5)305-13(2013 Oct)
Kullmann FA,McKenna D,Wells GI,Thor KB

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NMB cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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