ATP1B2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	ATP1B2
Entrez Gene ID	482
Full Name	ATPase Na+/K+ transporting subunit beta 2
Synonyms	AMOG
General protein information	Preferred Names ATPase Na+/K+ transporting subunit beta 2 Names sodium/potassium-transporting ATPase subunit beta-2 ATPase, Na+/K+ transporting, beta 2 polypeptide Na, K-ATPase beta-2 polypeptide adhesion molecule in glia adhesion molecule on glia sodium pump subunit beta-2 sodium-potassium ATPase subunit beta 2 (non-catalytic) sodium/potassium-dependent ATPase beta-2 subunit sodium/potassium-dependent ATPase subunit beta-2 sodium/potassium-transporting ATPase beta-2 chain
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 17 Map Location: 17p13.1
Summary	The protein encoded by this gene belongs to the family of Na+/K+ and H+/K+ ATPases beta chain proteins, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. The glycoprotein subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes a beta 2 subunit. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2014].
Disorder MIM:	182331

mRNA and Protein(s)

mRNA	Protein	Name
NM_001678.5	NP_001669.3	sodium/potassium-transporting ATPase subunit beta-2 isoform 1
NM_001678.4	NP_001669.3	sodium/potassium-transporting ATPase subunit beta-2 isoform 1
NM_001303263.1	NP_001290192.1	sodium/potassium-transporting ATPase subunit beta-2 isoform 2

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	ATP1B2	XP_001171996.1
	LOC716093	XP_001110335.1
Canis lupus familiaris (dog)	ATP1B2	XP_546597.2
Rattus norvegicus (Norway rat)	Atp1b2	NP_036639.2
Homo sapiens (human)	ATP1B2	NP_001669.3
Mus musculus (house mouse)	Atp1b2	NP_038201.1
Danio rerio (zebrafish)	atp1b2a	NP_571744.1
Danio rerio (zebrafish)	atp1b2b	NP_571913.1
Bos taurus (cattle)	ATP1B2	NP_777102.1
Drosophila melanogaster (fruit fly)	nrv1	NP_477167.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP007790	XP_001237968.1
Xenopus tropicalis (tropical clawed frog)	atp1b2	NP_989070.1

Gene Ontology
Bibliography

Related articles in PubMed

Joint analysis of three genome-wide association studies of esophageal squamous cell carcinoma in Chinese populations.
Wu C, Wang Z, Song X, Feng XS, Abnet CC, He J, Hu N, Zuo XB, Tan W, Zhan Q, Hu Z, He Z, Jia W, Zhou Y, Yu K, Shu XO, Yuan JM, Zheng W, Zhao XK, Gao SG, Yuan ZQ, Zhou FY, Fan ZM, Cui JL, Lin HL, Han XN, Li B, Chen X, Dawsey SM, Liao L, Lee MP, Ding T, Qiao YL, Liu Z, Liu Y, Yu D, Chang J, Wei L, Gao YT, Koh WP, Xiang YB, Tang ZZ, Fan JH, Han JJ, Zhou SL, Zhang P, Zhang DY, Yuan Y, Huang Y, Liu C, Zhai K, Qiao Y, Jin G, Guo C, Fu J, Miao X, Lu C, Yang H, Wang C, Wheeler WA, Gail M, Yeager M, Yuenger J, Guo ET, Li AL, Zhang W, Li XM, Sun LD, Ma BG, Li Y, Tang S, Peng XQ, Liu J, Hutchinson A, Jacobs K, Giffen C, Burdette L, Fraumeni JF Jr, Shen H, Ke Y, Zeng Y, Wu T, Kraft P, Chung CC, Tucker MA, Hou ZC, Liu YL, Hu YL, Liu Y, Wang L, Yuan G, Chen LS, Liu X, Ma T, Meng H, Sun L, Li XM, Li XM, Ku JW, Zhou YF, Yang LQ, Wang Z, Li Y, Qige Q, Yang WJ, Lei GY, Chen LQ, Li EM, Yuan L, Yue WB, Wang R, Wang LW, Fan XP, Zhu FH, Zhao WX, Mao YM, Zhang M, Xing GL, Li JL, Han M, Ren JL, Liu B, Ren SW, Kong QP, Li F, Sheyhidin I, Wei W, Zhang YR, Feng CW, Wang J, Yang YH, Hao HZ, Bao QD, Liu BC, Wu AQ, Xie D, Yang WC, Wang L, Zhao XH, Chen SQ, Hong JY, Zhang XJ, Freedman ND, Goldstein AM, Lin D, Taylor PR, Wang LD, Chanock SJ
Nature genetics46(9)1001-1006(2014 Sep)

Clonal heterogeneity of lymphoid malignancies correlates with poor prognosis.
Suguro M, Yoshida N, Umino A, Kato H, Tagawa H, Nakagawa M, Fukuhara N, Karnan S, Takeuchi I, Hocking TD, Arita K, Karube K, Tsuzuki S, Nakamura S, Kinoshita T, Seto M
Cancer science105(7)897-904(2014 Jul)

Na?/K?-ATPase ?2-subunit (AMOG) expression abrogates invasion of glioblastoma-derived brain tumor-initiating cells.
Sun MZ, Kim JM, Oh MC, Safaee M, Kaur G, Clark AJ, Bloch O, Ivan ME, Kaur R, Oh T, Fouse SD, Phillips JJ, Berger MS, Parsa AT
Neuro-oncology15(11)1518-31(2013 Nov)

Genome-wide association study of circulating estradiol, testosterone, and sex hormone-binding globulin in postmenopausal women.
Prescott J, Thompson DJ, Kraft P, Chanock SJ, Audley T, Brown J, Leyland J, Folkerd E, Doody D, Hankinson SE, Hunter DJ, Jacobs KB, Dowsett M, Cox DG, Easton DF, De Vivo I
PloS one7(6)e37815(2012)

The Na/K-ATPase is obligatory for membrane anchorage of retinoschisin, the protein involved in the pathogenesis of X-linked juvenile retinoschisis.
Friedrich U, St?hr H, Hilfinger D, Loenhardt T, Schachner M, Langmann T, Weber BH
Human molecular genetics20(6)1132-42(2011 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Retinoschisin, the protein involved in the pathogenesis of X-linked juvenile retinoschisis, membrane association is severely impaired in the absence of ATP1A3 and ATP1B2.
Title: The Na/K-ATPase is obligatory for membrane anchorage of retinoschisin, the protein involved in the pathogenesis of X-linked juvenile retinoschisis.

analysis of pathways for maturation of the Na,K-ATPase beta1 and beta2 subunits in the endoplasmic reticulum
Title: Diverse pathways for maturation of the Na,K-ATPase ?1 and ?2 subunits in the endoplasmic reticulum of Madin-Darby canine kidney cells.

The AMOG expression pattern with altered cellular distribution observed in malformations of cortical development suggests that AMOG might contribute to abnormal cortical development via mTOR activation.
Title: Expression patterns of AMOG in developing human cortex and malformations of cortical development.

Observational study of gene-disease association. (HuGE Navigator)
Title: Genetic susceptibility to distinct bladder cancer subphenotypes.

the ER quality control system allows export only of assembled alpha-beta complexes to the Golgi, whereas the number of alpha(1) subunits in the ER determines the amount of the alpha-beta complexes
Title: Assembly with the Na,K-ATPase alpha(1) subunit is required for export of beta(1) and beta(2) subunits from the endoplasmic reticulum.

The following ATP1B2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ATP1B2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu56404	NM_001678.5 Latest version!	Homo sapiens ATPase Na+/K+ transporting subunit beta 2 (ATP1B2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
OHu56405	NM_001303263.1 Latest version!	Homo sapiens ATPase Na+/K+ transporting subunit beta 2 (ATP1B2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00
View Old Accession Versions >>
OHu56404	NM_001678.4	Homo sapiens ATPase Na+/K+ transporting subunit beta 2 (ATP1B2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

ATP1B2 ( NM_001678.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_001669.3 Homo sapiens ATPase Na+/K+ transporting subunit beta 2 (ATP1B2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu56404
Clone ID Related Accession (Same CDS sequence)	NM_001678.5 , NM_001678.4
Accession Version	NM_001678.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 873bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-16
Organism	Homo sapiens(human)
Product	sodium/potassium-transporting ATPase subunit beta-2 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA122526.1, AK290143.1, AC007421.13 and AL120033.1. On Nov 22, 2018 this sequence version replaced NM_001678.4. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.934702.1, SRR3476690.267881.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968189, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000250111.9/ ENSP00000250111.4 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGTCATCC AGAAAGAGAA GAAGAGCTGC GGGCAGGTGG TTGAGGAGTG GAAGGAGTTC 
GTGTGGAACC CGAGGACGCA CCAGTTTATG GGCCGCACCG GGACCAGCTG GGCCTTTATC 
CTCCTCTTCT ACCTCGTTTT TTATGGGTTC CTCACCGCCA TGTTCACCCT CACCATGTGG 
GTGATGCTGC AGACTGTCTC CGACCATACC CCCAAGTACC AGGACCGACT GGCCACACCG 
GGCTTGATGA TTCGCCCCAA GACTGAGAAC CTTGATGTCA TTGTCAATGT CAGTGACACT 
GAAAGCTGGG ACCAGCATGT TCAGAAGCTC AACAAGTTCT TGGAGCCTTA CAACGACTCT 
ATCCAAGCCC AAAAGAATGA TGTCTGCCGC CCTGGACGCT ATTACGAACA GCCAGATAAT 
GGAGTCCTCA ACTACCCCAA ACGTGCCTGC CAATTCAACC GGACCCAGCT GGGCAACTGC 
TCCGGCATTG GGGACTCCAC CCACTATGGT TACAGCACTG GGCAGCCCTG TGTCTTCATC 
AAGATGAACC GGGTCATCAA CTTCTATGCA GGAGCAAACC AGAGCATGAA TGTTACCTGT 
GCTGGGAAGC GAGATGAAGA TGCTGAGAAT CTCGGCAACT TCGTCATGTT CCCCGCCAAC 
GGCAACATCG ACCTCATGTA CTTCCCCTAC TATGGCAAAA AGTTCCACGT GAACTACACA 
CAGCCCCTGG TGGCTGTGAA GTTCCTGAAT GTGACCCCCA ACGTGGAGGT GAATGTAGAA 
TGTCGCATCA ACGCCGCCAA CATCGCCACA GACGATGAGC GAGACAAGTT CGCCGGCCGC 
GTGGCCTTCA AACTCCGCAT CAACAAAACC TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001669.3
CDS	594..1466
Translation	MVIQKEKKSCGQVVEEWKEFVWNPRTHQFMGRTGTSWAFILLFYLVFYGFLTAMFTLTMWVMLQTVSDHTPKYQDRLATPGLMIRPKTENLDVIVNVSDTESWDQHVQKLNKFLEPYNDSIQAQKNDVCRPGRYYEQPDNGVLNYPKRACQFNRTQLGNCSGIGDSTHYGYSTGQPCVFIKMNRVINFYAGANQSMNVTCAGKRDEDAENLGNFVMFPANGNIDLMYFPYYGKKFHVNYTQPLVAVKFLNVTPNVEVNVECRINAANIATDDERDKFAGRVAFKLRINKT

Target ORF information:

RefSeq Version	NM_001678.5
Organism	Homo sapiens(human)
Definition	Homo sapiens ATPase Na+/K+ transporting subunit beta 2 (ATP1B2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001678.5

ORF Insert Sequence:

ATGGTCATCC AGAAAGAGAA GAAGAGCTGC GGGCAGGTGG TTGAGGAGTG GAAGGAGTTC 
GTGTGGAACC CGAGGACGCA CCAGTTTATG GGCCGCACCG GGACCAGCTG GGCCTTTATC 
CTCCTCTTCT ACCTCGTTTT TTATGGGTTC CTCACCGCCA TGTTCACCCT CACCATGTGG 
GTGATGCTGC AGACTGTCTC CGACCATACC CCCAAGTACC AGGACCGACT GGCCACACCG 
GGCTTGATGA TTCGCCCCAA GACTGAGAAC CTTGATGTCA TTGTCAATGT CAGTGACACT 
GAAAGCTGGG ACCAGCATGT TCAGAAGCTC AACAAGTTCT TGGAGCCTTA CAACGACTCT 
ATCCAAGCCC AAAAGAATGA TGTCTGCCGC CCTGGACGCT ATTACGAACA GCCAGATAAT 
GGAGTCCTCA ACTACCCCAA ACGTGCCTGC CAATTCAACC GGACCCAGCT GGGCAACTGC 
TCCGGCATTG GGGACTCCAC CCACTATGGT TACAGCACTG GGCAGCCCTG TGTCTTCATC 
AAGATGAACC GGGTCATCAA CTTCTATGCA GGAGCAAACC AGAGCATGAA TGTTACCTGT 
GCTGGGAAGC GAGATGAAGA TGCTGAGAAT CTCGGCAACT TCGTCATGTT CCCCGCCAAC 
GGCAACATCG ACCTCATGTA CTTCCCCTAC TATGGCAAAA AGTTCCACGT GAACTACACA 
CAGCCCCTGG TGGCTGTGAA GTTCCTGAAT GTGACCCCCA ACGTGGAGGT GAATGTAGAA 
TGTCGCATCA ACGCCGCCAA CATCGCCACA GACGATGAGC GAGACAAGTT CGCCGGCCGC 
GTGGCCTTCA AACTCCGCAT CAACAAAACC TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ATP1B2 ( NM_001678.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_001669.3 Homo sapiens ATPase Na+/K+ transporting subunit beta 2 (ATP1B2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu56404
Clone ID Related Accession (Same CDS sequence)	NM_001678.5 , NM_001678.4
Accession Version	NM_001678.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 873bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-27
Organism	Homo sapiens(human)
Product	sodium/potassium-transporting ATPase subunit beta-2 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA122526.1, AK290143.1, AC007421.13 and AL120033.1. On Dec 24, 2014 this sequence version replaced NM_001678.3. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: M81181.1, BC126175.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968189, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

ATGGTCATCC AGAAAGAGAA GAAGAGCTGC GGGCAGGTGG TTGAGGAGTG GAAGGAGTTC 
GTGTGGAACC CGAGGACGCA CCAGTTTATG GGCCGCACCG GGACCAGCTG GGCCTTTATC 
CTCCTCTTCT ACCTCGTTTT TTATGGGTTC CTCACCGCCA TGTTCACCCT CACCATGTGG 
GTGATGCTGC AGACTGTCTC CGACCATACC CCCAAGTACC AGGACCGACT GGCCACACCG 
GGCTTGATGA TTCGCCCCAA GACTGAGAAC CTTGATGTCA TTGTCAATGT CAGTGACACT 
GAAAGCTGGG ACCAGCATGT TCAGAAGCTC AACAAGTTCT TGGAGCCTTA CAACGACTCT 
ATCCAAGCCC AAAAGAATGA TGTCTGCCGC CCTGGACGCT ATTACGAACA GCCAGATAAT 
GGAGTCCTCA ACTACCCCAA ACGTGCCTGC CAATTCAACC GGACCCAGCT GGGCAACTGC 
TCCGGCATTG GGGACTCCAC CCACTATGGT TACAGCACTG GGCAGCCCTG TGTCTTCATC 
AAGATGAACC GGGTCATCAA CTTCTATGCA GGAGCAAACC AGAGCATGAA TGTTACCTGT 
GCTGGGAAGC GAGATGAAGA TGCTGAGAAT CTCGGCAACT TCGTCATGTT CCCCGCCAAC 
GGCAACATCG ACCTCATGTA CTTCCCCTAC TATGGCAAAA AGTTCCACGT GAACTACACA 
CAGCCCCTGG TGGCTGTGAA GTTCCTGAAT GTGACCCCCA ACGTGGAGGT GAATGTAGAA 
TGTCGCATCA ACGCCGCCAA CATCGCCACA GACGATGAGC GAGACAAGTT CGCCGGCCGC 
GTGGCCTTCA AACTCCGCAT CAACAAAACC TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001669.3
CDS	630..1502
Translation	MVIQKEKKSCGQVVEEWKEFVWNPRTHQFMGRTGTSWAFILLFYLVFYGFLTAMFTLTMWVMLQTVSDHTPKYQDRLATPGLMIRPKTENLDVIVNVSDTESWDQHVQKLNKFLEPYNDSIQAQKNDVCRPGRYYEQPDNGVLNYPKRACQFNRTQLGNCSGIGDSTHYGYSTGQPCVFIKMNRVINFYAGANQSMNVTCAGKRDEDAENLGNFVMFPANGNIDLMYFPYYGKKFHVNYTQPLVAVKFLNVTPNVEVNVECRINAANIATDDERDKFAGRVAFKLRINKT

Target ORF information:

RefSeq Version	NM_001678.4
Organism	Homo sapiens(human)
Definition	Homo sapiens ATPase Na+/K+ transporting subunit beta 2 (ATP1B2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001678.4

ORF Insert Sequence:

ATGGTCATCC AGAAAGAGAA GAAGAGCTGC GGGCAGGTGG TTGAGGAGTG GAAGGAGTTC 
GTGTGGAACC CGAGGACGCA CCAGTTTATG GGCCGCACCG GGACCAGCTG GGCCTTTATC 
CTCCTCTTCT ACCTCGTTTT TTATGGGTTC CTCACCGCCA TGTTCACCCT CACCATGTGG 
GTGATGCTGC AGACTGTCTC CGACCATACC CCCAAGTACC AGGACCGACT GGCCACACCG 
GGCTTGATGA TTCGCCCCAA GACTGAGAAC CTTGATGTCA TTGTCAATGT CAGTGACACT 
GAAAGCTGGG ACCAGCATGT TCAGAAGCTC AACAAGTTCT TGGAGCCTTA CAACGACTCT 
ATCCAAGCCC AAAAGAATGA TGTCTGCCGC CCTGGACGCT ATTACGAACA GCCAGATAAT 
GGAGTCCTCA ACTACCCCAA ACGTGCCTGC CAATTCAACC GGACCCAGCT GGGCAACTGC 
TCCGGCATTG GGGACTCCAC CCACTATGGT TACAGCACTG GGCAGCCCTG TGTCTTCATC 
AAGATGAACC GGGTCATCAA CTTCTATGCA GGAGCAAACC AGAGCATGAA TGTTACCTGT 
GCTGGGAAGC GAGATGAAGA TGCTGAGAAT CTCGGCAACT TCGTCATGTT CCCCGCCAAC 
GGCAACATCG ACCTCATGTA CTTCCCCTAC TATGGCAAAA AGTTCCACGT GAACTACACA 
CAGCCCCTGG TGGCTGTGAA GTTCCTGAAT GTGACCCCCA ACGTGGAGGT GAATGTAGAA 
TGTCGCATCA ACGCCGCCAA CATCGCCACA GACGATGAGC GAGACAAGTT CGCCGGCCGC 
GTGGCCTTCA AACTCCGCAT CAACAAAACC TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ATP1B2 ( NM_001303263.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001290192.1 Homo sapiens ATPase Na+/K+ transporting subunit beta 2 (ATP1B2), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu56405
Clone ID Related Accession (Same CDS sequence)	NM_001303263.1
Accession Version	NM_001303263.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 627bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-15
Organism	Homo sapiens(human)
Product	sodium/potassium-transporting ATPase subunit beta-2 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA199365.1, AC007421.13, AK290143.1 and AL120033.1. Transcript Variant: This variant (2) uses an upstream exon in place of the first two exons and initiates translation at a downstream site compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: DA199365.1, DA875666.1 [ECO:0000332] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGATTCGCC CCAAGACTGA GAACCTTGAT GTCATTGTCA ATGTCAGTGA CACTGAAAGC 
TGGGACCAGC ATGTTCAGAA GCTCAACAAG TTCTTGGAGC CTTACAACGA CTCTATCCAA 
GCCCAAAAGA ATGATGTCTG CCGCCCTGGA CGCTATTACG AACAGCCAGA TAATGGAGTC 
CTCAACTACC CCAAACGTGC CTGCCAATTC AACCGGACCC AGCTGGGCAA CTGCTCCGGC 
ATTGGGGACT CCACCCACTA TGGTTACAGC ACTGGGCAGC CCTGTGTCTT CATCAAGATG 
AACCGGGTCA TCAACTTCTA TGCAGGAGCA AACCAGAGCA TGAATGTTAC CTGTGCTGGG 
AAGCGAGATG AAGATGCTGA GAATCTCGGC AACTTCGTCA TGTTCCCCGC CAACGGCAAC 
ATCGACCTCA TGTACTTCCC CTACTATGGC AAAAAGTTCC ACGTGAACTA CACACAGCCC 
CTGGTGGCTG TGAAGTTCCT GAATGTGACC CCCAACGTGG AGGTGAATGT AGAATGTCGC 
ATCAACGCCG CCAACATCGC CACAGACGAT GAGCGAGACA AGTTCGCCGG CCGCGTGGCC 
TTCAAACTCC GCATCAACAA AACCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001290192.1
CDS	81..707
Translation	MIRPKTENLDVIVNVSDTESWDQHVQKLNKFLEPYNDSIQAQKNDVCRPGRYYEQPDNGVLNYPKRACQFNRTQLGNCSGIGDSTHYGYSTGQPCVFIKMNRVINFYAGANQSMNVTCAGKRDEDAENLGNFVMFPANGNIDLMYFPYYGKKFHVNYTQPLVAVKFLNVTPNVEVNVECRINAANIATDDERDKFAGRVAFKLRINKT

Target ORF information:

RefSeq Version	NM_001303263.1
Organism	Homo sapiens(human)
Definition	Homo sapiens ATPase Na+/K+ transporting subunit beta 2 (ATP1B2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001303263.1

ORF Insert Sequence:

ATGATTCGCC CCAAGACTGA GAACCTTGAT GTCATTGTCA ATGTCAGTGA CACTGAAAGC 
TGGGACCAGC ATGTTCAGAA GCTCAACAAG TTCTTGGAGC CTTACAACGA CTCTATCCAA 
GCCCAAAAGA ATGATGTCTG CCGCCCTGGA CGCTATTACG AACAGCCAGA TAATGGAGTC 
CTCAACTACC CCAAACGTGC CTGCCAATTC AACCGGACCC AGCTGGGCAA CTGCTCCGGC 
ATTGGGGACT CCACCCACTA TGGTTACAGC ACTGGGCAGC CCTGTGTCTT CATCAAGATG 
AACCGGGTCA TCAACTTCTA TGCAGGAGCA AACCAGAGCA TGAATGTTAC CTGTGCTGGG 
AAGCGAGATG AAGATGCTGA GAATCTCGGC AACTTCGTCA TGTTCCCCGC CAACGGCAAC 
ATCGACCTCA TGTACTTCCC CTACTATGGC AAAAAGTTCC ACGTGAACTA CACACAGCCC 
CTGGTGGCTG TGAAGTTCCT GAATGTGACC CCCAACGTGG AGGTGAATGT AGAATGTCGC 
ATCAACGCCG CCAACATCGC CACAGACGAT GAGCGAGACA AGTTCGCCGG CCGCGTGGCC 
TTCAAACTCC GCATCAACAA AACCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Joint analysis of three genome-wide association studies of esophageal squamous cell carcinoma in Chinese populations.
Nature genetics46(9)1001-1006(2014 Sep)
Wu C,Wang Z,Song X,Feng XS,Abnet CC,He J,Hu N,Zuo XB,Tan W,Zhan Q,Hu Z,He Z,Jia W,Zhou Y,Yu K,Shu XO,Yuan JM,Zheng W,Zhao XK,Gao SG,Yuan ZQ,Zhou FY,Fan ZM,Cui JL,Lin HL,Han XN,Li B,Chen X,Dawsey SM,Liao L,Lee MP,Ding T,Qiao YL,Liu Z,Liu Y,Yu D,Chang J,Wei L,Gao YT,Koh WP,Xiang YB,Tang ZZ,Fan JH,Han JJ,Zhou SL,Zhang P,Zhang DY,Yuan Y,Huang Y,Liu C,Zhai K,Qiao Y,Jin G,Guo C,Fu J,Miao X,Lu C,Yang H,Wang C,Wheeler WA,Gail M,Yeager M,Yuenger J,Guo ET,Li AL,Zhang W,Li XM,Sun LD,Ma BG,Li Y,Tang S,Peng XQ,Liu J,Hutchinson A,Jacobs K,Giffen C,Burdette L,Fraumeni JF Jr,Shen H,Ke Y,Zeng Y,Wu T,Kraft P,Chung CC,Tucker MA,Hou ZC,Liu YL,Hu YL,Liu Y,Wang L,Yuan G,Chen LS,Liu X,Ma T,Meng H,Sun L,Li XM,Li XM,Ku JW,Zhou YF,Yang LQ,Wang Z,Li Y,Qige Q,Yang WJ,Lei GY,Chen LQ,Li EM,Yuan L,Yue WB,Wang R,Wang LW,Fan XP,Zhu FH,Zhao WX,Mao YM,Zhang M,Xing GL,Li JL,Han M,Ren JL,Liu B,Ren SW,Kong QP,Li F,Sheyhidin I,Wei W,Zhang YR,Feng CW,Wang J,Yang YH,Hao HZ,Bao QD,Liu BC,Wu AQ,Xie D,Yang WC,Wang L,Zhao XH,Chen SQ,Hong JY,Zhang XJ,Freedman ND,Goldstein AM,Lin D,Taylor PR,Wang LD,Chanock SJ

Clonal heterogeneity of lymphoid malignancies correlates with poor prognosis.
Cancer science105(7)897-904(2014 Jul)
Suguro M,Yoshida N,Umino A,Kato H,Tagawa H,Nakagawa M,Fukuhara N,Karnan S,Takeuchi I,Hocking TD,Arita K,Karube K,Tsuzuki S,Nakamura S,Kinoshita T,Seto M

Na?/K?-ATPase ?2-subunit (AMOG) expression abrogates invasion of glioblastoma-derived brain tumor-initiating cells.
Neuro-oncology15(11)1518-31(2013 Nov)
Sun MZ,Kim JM,Oh MC,Safaee M,Kaur G,Clark AJ,Bloch O,Ivan ME,Kaur R,Oh T,Fouse SD,Phillips JJ,Berger MS,Parsa AT

Genome-wide association study of circulating estradiol, testosterone, and sex hormone-binding globulin in postmenopausal women.
PloS one7(6)e37815(2012)
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The Na/K-ATPase is obligatory for membrane anchorage of retinoschisin, the protein involved in the pathogenesis of X-linked juvenile retinoschisis.
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ATP1B2 cDNA ORF clone, Homo sapiens(human)

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