ATP1A4 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	ATP1A4
Entrez Gene ID	480
Full Name	ATPase Na+/K+ transporting subunit alpha 4
Synonyms	ATP1A1,ATP1AL2
General protein information	Preferred Names ATPase Na+/K+ transporting subunit alpha 4 Names sodium/potassium-transporting ATPase subunit alpha-4 ATPase, Na+/K+ transporting, alpha 4 polypeptide ATPase, Na+/K+ transporting, alpha polypeptide-like 2 Na(+)/K(+) ATPase alpha-4 subunit Na+/K+ ATPase 4 Na+/K+ ATPase, alpha-D polypeptide Na,K-ATPase subunit alpha-C sodium pump 4 sodium pump subunit alpha-4 sodium-potassium ATPase catalytic subunit alpha-4 sodium/potassium-transporting ATPase alpha-4 chain
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1q23.2
Summary	The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 4 subunit. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008].
Disorder MIM:	607321

mRNA and Protein(s)

mRNA	Protein	Name
XM_011509582.1	XP_011507884.1	sodium/potassium-transporting ATPase subunit alpha-4 isoform X1
NM_144699.3	NP_653300.2	sodium/potassium-transporting ATPase subunit alpha-4 isoform 1
NM_001001734.1	NP_001001734.1	sodium/potassium-transporting ATPase subunit alpha-4 isoform 2
NM_144699.4	NP_653300.2	sodium/potassium-transporting ATPase subunit alpha-4 isoform 1

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Atp1a4	NP_001257959.1
Homo sapiens (human)	ATP1A4	NP_653300.2
Pan troglodytes (chimpanzee)	ATP1A4	XP_001171135.1
	ATP1A4	XP_001117376.1
Canis lupus familiaris (dog)	ATP1A4	XP_545754.3
Mus musculus (house mouse)	Atp1a4	NP_038762.1
Bos taurus (cattle)	ATP1A4	NP_001137575.1

Gene Ontology
Bibliography

Related articles in PubMed

Role of human Na,K-ATPase alpha 4 in sperm function, derived from studies in transgenic mice.
McDermott J, S?nchez G, Nangia AK, Blanco G
Molecular reproduction and development82(3)167-81(2015 Mar)

The transcription factor CREMtau and cAMP regulate promoter activity of the Na,K-ATPase alpha4 isoform.
Rodova M, Nguyen AN, Blanco G
Molecular reproduction and development73(11)1435-47(2006 Nov)

The human Na,K-ATPase alpha 4 isoform is a ouabain-sensitive alpha isoform that is expressed in sperm.
Hlivko JT, Chakraborty S, Hlivko TJ, Sengupta A, James PF
Molecular reproduction and development73(1)101-15(2006 Jan)

Biology, structure and mechanism of P-type ATPases.
K?hlbrandt W
Nature reviews. Molecular cell biology5(4)282-95(2004 Apr)

Functional roles of the alpha isoforms of the Na,K-ATPase.
Lingrel J, Moseley A, Dostanic I, Cougnon M, He S, James P, Woo A, O'Connor K, Neumann J
Annals of the New York Academy of Sciences986354-9(2003 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Human ATP1A4 enhances mouse sperm motility and hyperactivity during capacitation.
Title: Role of human Na,K-ATPase alpha 4 in sperm function, derived from studies in transgenic mice.

These results constitute the first demonstration of the transcriptional control of ATP1A4 gene expression by cAMP and by CREMtau, a transcription factor essential for male germ cell gene expression.
Title: The transcription factor CREMtau and cAMP regulate promoter activity of the Na,K-ATPase alpha4 isoform.

Human Na,K-ATPase alpha 4 isoform is a sperm-specific protein localized to the flagellum, suggesting a role for human Na,K-ATPase alpha 4 isoform in human sperm physiology.
Title: The human Na,K-ATPase alpha 4 isoform is a ouabain-sensitive alpha isoform that is expressed in sperm.

The following ATP1A4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ATP1A4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu29787	NM_001001734.1 Latest version!	Homo sapiens ATPase Na+/K+ transporting subunit alpha 4 (ATP1A4), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu56403	XM_011509582.1 Latest version!	Homo sapiens ATPase Na+/K+ transporting subunit alpha 4 (ATP1A4), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$475.30 $679.00
OHu30844	NM_144699.4 Latest version!	Homo sapiens ATPase Na+/K+ transporting subunit alpha 4 (ATP1A4), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	19-21	$559.30 $799.00
View Old Accession Versions >>
OHu30844	NM_144699.3	Homo sapiens ATPase Na+/K+ transporting subunit alpha 4 (ATP1A4), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	20	$384.30 $549.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

ATP1A4 ( NM_001001734.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001001734.1 Homo sapiens ATPase Na+/K+ transporting subunit alpha 4 (ATP1A4), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu29787
Clone ID Related Accession (Same CDS sequence)	NM_001001734.1
Accession Version	NM_001001734.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 498bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-15
Organism	Homo sapiens(human)
Product	sodium/potassium-transporting ATPase subunit alpha-4 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC028297.1. Transcript Variant: This variant (2) contains a distinct 5' UTR and lacks an in-frame portion of the 5' coding region, compared to variant 1. The resulting isoform (2), which has not been experimentally confirmed, has a shorter N-terminus when compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC028297.1, BX359636.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968968 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGATCCAGG CTCTGGCTGG ATTCTTTACC TACTTTGTAA TCCTGGCTGA GAATGGTTTT 
AGGCCTGTTG ATCTGCTGGG CATCCGCCTC CACTGGGAAG ATAAATACTT GAATGACCTG 
GAGGACAGCT ACGGACAGCA GTGGACCTAT GAGCAACGAA AAGTTGTGGA GTTCACATGC 
CAAACGGCCT TTTTTGTCAC CATCGTGGTT GTGCAGTGGG CGGATCTCAT CATCTCCAAG 
ACTCGCCGCA ACTCACTTTT CCAGCAGGGC ATGAGAAACA AAGTCTTAAT ATTTGGGATC 
CTGGAGGAGA CACTCTTGGC TGCATTTCTG TCCTACACTC CAGGCATGGA CGTGGCCCTG 
CGAATGTACC CACTCAAGAT AACCTGGTGG CTCTGTGCCA TTCCCTACAG TATTCTCATC 
TTCGTCTATG ATGAAATCAG AAAACTCCTC ATCCGTCAGC ACCCGGATGG CTGGGTGGAA 
AGGGAGACGT ACTACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001001734.1
CDS	111..608
Translation	MIQALAGFFTYFVILAENGFRPVDLLGIRLHWEDKYLNDLEDSYGQQWTYEQRKVVEFTCQTAFFVTIVVVQWADLIISKTRRNSLFQQGMRNKVLIFGILEETLLAAFLSYTPGMDVALRMYPLKITWWLCAIPYSILIFVYDEIRKLLIRQHPDGWVERETYY

Target ORF information:

RefSeq Version	NM_001001734.1
Organism	Homo sapiens(human)
Definition	Homo sapiens ATPase Na+/K+ transporting subunit alpha 4 (ATP1A4), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001001734.1

ORF Insert Sequence:

ATGATCCAGG CTCTGGCTGG ATTCTTTACC TACTTTGTAA TCCTGGCTGA GAATGGTTTT 
AGGCCTGTTG ATCTGCTGGG CATCCGCCTC CACTGGGAAG ATAAATACTT GAATGACCTG 
GAGGACAGCT ACGGACAGCA GTGGACCTAT GAGCAACGAA AAGTTGTGGA GTTCACATGC 
CAAACGGCCT TTTTTGTCAC CATCGTGGTT GTGCAGTGGG CGGATCTCAT CATCTCCAAG 
ACTCGCCGCA ACTCACTTTT CCAGCAGGGC ATGAGAAACA AAGTCTTAAT ATTTGGGATC 
CTGGAGGAGA CACTCTTGGC TGCATTTCTG TCCTACACTC CAGGCATGGA CGTGGCCCTG 
CGAATGTACC CACTCAAGAT AACCTGGTGG CTCTGTGCCA TTCCCTACAG TATTCTCATC 
TTCGTCTATG ATGAAATCAG AAAACTCCTC ATCCGTCAGC ACCCGGATGG CTGGGTGGAA 
AGGGAGACGT ACTACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ATP1A4 ( XM_011509582.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_011507884.1 Homo sapiens ATPase Na+/K+ transporting subunit alpha 4 (ATP1A4), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu56403
Clone ID Related Accession (Same CDS sequence)	XM_011509582.1
Accession Version	XM_011509582.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2913bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	sodium/potassium-transporting ATPase subunit alpha-4 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000001.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGACACTA CCTGGAAAAA GCTGCAAATG GGCCATAGCC ACCAAAGGGC AAAGGAAATC 
CTGACTCGAG GTGGACCCAA TACTGTTACC CCACCCCCCA CCACTCCAGA ATGGGTCAAA 
TTCTGTAAGC AACTGTTCGG AGGCTTCTCC CTCCTACTAT GGACTGGGGC CATTCTCTGC 
TTTGTGGCCT ACAGCATCCA GATATATTTC AATGAGGAGC CTACCAAAGA CAACCTCTAC 
CTGAGCATCG TACTGTCCGT CGTGGTCATC GTCACTGGCT GCTTCTCCTA TTATCAGGAG 
GCCAAGAGCT CCAAGATCAT GGAGTCTTTT AAGAACATGG TGCCTCAGCA AGCTCTGGTA 
ATTCGAGGAG GAGAGAAGAT GCAAATTAAT GTACAAGAGG TGGTGTTGGG AGACCTGGTG 
GAAATCAAGG GTGGAGACCG AGTCCCTGCT GACCTCCGGC TTATCTCTGC ACAAGGATGT 
AAGGTGGACA ACTCATCCTT GACTGGGGAG TCAGAACCCC AGAGCCGCTC CCCTGACTTC 
ACCCATGAGA ACCCTCTGGA GACCCGAAAC ATCTGCTTCT TTTCCACCAA CTGTGTGGAA 
GGAACCGCCC GGGGTATTGT GATTGCTACG GGAGACTCCA CAGTGATGGG CAGAATTGCC 
TCCCTGACGT CAGGCCTGGC GGTTGGCCAG ACACCTATCG CTGCTGAGAT CGAACACTTC 
ATCCATCTGA TCACTGTGGT GGCCGTCTTC CTTGGTGTCA CTTTTTTTGC GCTCTCACTT 
CTCTTGGGCT ATGGTTGGCT GGAGGCTATC ATTTTTCTCA TTGGCATCAT TGTGGCCAAT 
GTGCCTGAGG GGCTGTTGGC CACAGTCACT GTGTGCCTGA CCCTCACAGC CAAGCGCATG 
GCGCGGAAGA ACTGCCTGGT GAAGAACCTG GAGGCGGTGG AGACGCTGGG CTCCACGTCC 
ACCATCTGCT CAGACAAGAC GGGCACCCTC ACCCAGAACC GCATGACCGT CGCCCACATG 
TGGTTTGATA TGACCGTGTA TGAGGCCGAC ACCACTGAAG AACAGACTGG AAAAACATTT 
ACCAAGAGCT CTGATACCTG GTTTATGCTG GCCCGAATCG CTGGCCTCTG CAACCGGGCT 
GACTTTAAGG CTAATCAGGA GATCCTGCCC ATTGCTAAGA GGGCCACAAC AGGTGATGCT 
TCCGAGTCAG CCCTCCTCAA GTTCATCGAG CAGTCTTACA GCTCTGTGGC GGAGATGAGA 
GAGAAAAACC CCAAGGTGGC AGAGATTCCC TTTAATTCTA CCAACAAGTA CCAGATGTCC 
ATCCACCTTC GGGAGGACAG CTCCCAGACC CACGTACTGA TGATGAAGGG TGCTCCGGAG 
AGGATCTTGG AGTTTTGTTC TACCTTTCTT CTGAATGGGC AGGAGTACTC AATGAACGAT 
GAAATGAAGG AAGCCTTCCA AAATGCCTAC TTAGAACTGG GAGGTCTGGG GGAACGTGTG 
CTAGGCTTCT GCTTCTTGAA TCTGCCTAGC AGCTTCTCCA AGGGATTCCC ATTTAATACA 
GATGAAATAA ATTTCCCCAT GGACAACCTT TGTTTTGTGG GCCTCATATC CATGATTGAC 
CCTCCCCGAG CTGCAGTGCC TGATGCTGTG AGCAAGTGTC GCAGTGCAGG AATTAAGGTG 
ATCATGGTAA CAGGAGATCA TCCCATTACA GCTAAGGCCA TTGCCAAGGG TGTGGGCATC 
ATCTCAGAAG GCACTGAGAC GGCAGAGGAA GTCGCTGCCC GGCTTAAGAT CCCTATCAGC 
AAGGTCGATG CCAGTGCTGC CAAAGCCATT GTGGTGCATG GTGCAGAACT GAAGGACATA 
CAGTCCAAGC AGCTTGATCA GATCCTCCAG AACCACCCTG AGATCGTGTT TGCTCGGACC 
TCCCCTCAGC AGAAGCTCAT CATTGTCGAG GGATGTCAGA GGCTGGGAGC CGTTGTGGCC 
GTGACAGGTG ACGGGGTGAA CGACTCCCCT GCGCTGAAGA AGGCTGACAT TGGCATTGCC 
ATGGGCATCT CTGGCTCTGA CGTCTCTAAG CAGGCAGCCG ACATGATCCT GCTGGATGAC 
AACTTTGCCT CCATCGTCAC GGGGGTGGAG GAGGGCCGCC TGATCTTTGA CAACCTGAAG 
AAATCCATCA TGTACACCCT GACCAGCAAC ATCCCCGAGA TCACGCCCTT CCTGATGTTC 
ATCATCCTCG GTATACCCCT GCCTCTGGGA ACCATAACCA TCCTCTGCAT TGATCTCGGC 
ACTGACATGG TCCCTGCCAT CTCCTTGGCT TATGAGTCAG CTGAAAGCGA CATCATGAAG 
AGGCTTCCAA GGAACCCAAA GACGGATAAT CTGGTGAACC ACCGTCTCAT TGGCATGGCC 
TATGGACAGA TTGGGATGAT CCAGGCTCTG GCTGGATTCT TTACCTACTT TGTAATCCTG 
GCTGAGAATG GTTTTAGGCC TGTTGATCTG CTGGGCATCC GCCTCCACTG GGAAGATAAA 
TACTTGAATG ACCTGGAGGA CAGCTACGGA CAGCAGTGGA CCTATGAGCA ACGAAAAGTT 
GTGGAGTTCA CATGCCAAAC GGCCTTTTTT GTCACCATCG TGGTTGTGCA GTGGGCGGAT 
CTCATCATCT CCAAGACTCG CCGCAACTCA CTTTTCCAGC AGGGCATGAG AAACAAAGTC 
TTAATATTTG GGATCCTGGA GGAGACACTC TTGGCTGCAT TTCTGTCCTA CACTCCAGGC 
ATGGACGTGG CCCTGCGAAT GTACCCACTC AAGATAACCT GGTGGCTCTG TGCCATTCCC 
TACAGTATTC TCATCTTCGT CTATGATGAA ATCAGAAAAC TCCTCATCCG TCAGCACCCG 
GATGGCTGGG TGGAAAGGGA GACGTACTAC TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011507884.1
CDS	124..3036
Translation	MDTTWKKLQMGHSHQRAKEILTRGGPNTVTPPPTTPEWVKFCKQLFGGFSLLLWTGAILCFVAYSIQIYFNEEPTKDNLYLSIVLSVVVIVTGCFSYYQEAKSSKIMESFKNMVPQQALVIRGGEKMQINVQEVVLGDLVEIKGGDRVPADLRLISAQGCKVDNSSLTGESEPQSRSPDFTHENPLETRNICFFSTNCVEGTARGIVIATGDSTVMGRIASLTSGLAVGQTPIAAEIEHFIHLITVVAVFLGVTFFALSLLLGYGWLEAIIFLIGIIVANVPEGLLATVTVCLTLTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDMTVYEADTTEEQTGKTFTKSSDTWFMLARIAGLCNRADFKANQEILPIAKRATTGDASESALLKFIEQSYSSVAEMREKNPKVAEIPFNSTNKYQMSIHLREDSSQTHVLMMKGAPERILEFCSTFLLNGQEYSMNDEMKEAFQNAYLELGGLGERVLGFCFLNLPSSFSKGFPFNTDEINFPMDNLCFVGLISMIDPPRAAVPDAVSKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGTETAEEVAARLKIPISKVDASAAKAIVVHGAELKDIQSKQLDQILQNHPEIVFARTSPQQKLIIVEGCQRLGAVVAVTGDGVNDSPALKKADIGIAMGISGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIMYTLTSNIPEITPFLMFIILGIPLPLGTITILCIDLGTDMVPAISLAYESAESDIMKRLPRNPKTDNLVNHRLIGMAYGQIGMIQALAGFFTYFVILAENGFRPVDLLGIRLHWEDKYLNDLEDSYGQQWTYEQRKVVEFTCQTAFFVTIVVVQWADLIISKTRRNSLFQQGMRNKVLIFGILEETLLAAFLSYTPGMDVALRMYPLKITWWLCAIPYSILIFVYDEIRKLLIRQHPDGWVERETYY

Target ORF information:

RefSeq Version	XM_011509582.1
Organism	Homo sapiens(human)
Definition	Homo sapiens ATPase Na+/K+ transporting subunit alpha 4 (ATP1A4), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011509582.1

ORF Insert Sequence:

ATGGACACTA CCTGGAAAAA GCTGCAAATG GGCCATAGCC ACCAAAGGGC AAAGGAAATC 
CTGACTCGAG GTGGACCCAA TACTGTTACC CCACCCCCCA CCACTCCAGA ATGGGTCAAA 
TTCTGTAAGC AACTGTTCGG AGGCTTCTCC CTCCTACTAT GGACTGGGGC CATTCTCTGC 
TTTGTGGCCT ACAGCATCCA GATATATTTC AATGAGGAGC CTACCAAAGA CAACCTCTAC 
CTGAGCATCG TACTGTCCGT CGTGGTCATC GTCACTGGCT GCTTCTCCTA TTATCAGGAG 
GCCAAGAGCT CCAAGATCAT GGAGTCTTTT AAGAACATGG TGCCTCAGCA AGCTCTGGTA 
ATTCGAGGAG GAGAGAAGAT GCAAATTAAT GTACAAGAGG TGGTGTTGGG AGACCTGGTG 
GAAATCAAGG GTGGAGACCG AGTCCCTGCT GACCTCCGGC TTATCTCTGC ACAAGGATGT 
AAGGTGGACA ACTCATCCTT GACTGGGGAG TCAGAACCCC AGAGCCGCTC CCCTGACTTC 
ACCCATGAGA ACCCTCTGGA GACCCGAAAC ATCTGCTTCT TTTCCACCAA CTGTGTGGAA 
GGAACCGCCC GGGGTATTGT GATTGCTACG GGAGACTCCA CAGTGATGGG CAGAATTGCC 
TCCCTGACGT CAGGCCTGGC GGTTGGCCAG ACACCTATCG CTGCTGAGAT CGAACACTTC 
ATCCATCTGA TCACTGTGGT GGCCGTCTTC CTTGGTGTCA CTTTTTTTGC GCTCTCACTT 
CTCTTGGGCT ATGGTTGGCT GGAGGCTATC ATTTTTCTCA TTGGCATCAT TGTGGCCAAT 
GTGCCTGAGG GGCTGTTGGC CACAGTCACT GTGTGCCTGA CCCTCACAGC CAAGCGCATG 
GCGCGGAAGA ACTGCCTGGT GAAGAACCTG GAGGCGGTGG AGACGCTGGG CTCCACGTCC 
ACCATCTGCT CAGACAAGAC GGGCACCCTC ACCCAGAACC GCATGACCGT CGCCCACATG 
TGGTTTGATA TGACCGTGTA TGAGGCCGAC ACCACTGAAG AACAGACTGG AAAAACATTT 
ACCAAGAGCT CTGATACCTG GTTTATGCTG GCCCGAATCG CTGGCCTCTG CAACCGGGCT 
GACTTTAAGG CTAATCAGGA GATCCTGCCC ATTGCTAAGA GGGCCACAAC AGGTGATGCT 
TCCGAGTCAG CCCTCCTCAA GTTCATCGAG CAGTCTTACA GCTCTGTGGC GGAGATGAGA 
GAGAAAAACC CCAAGGTGGC AGAGATTCCC TTTAATTCTA CCAACAAGTA CCAGATGTCC 
ATCCACCTTC GGGAGGACAG CTCCCAGACC CACGTACTGA TGATGAAGGG TGCTCCGGAG 
AGGATCTTGG AGTTTTGTTC TACCTTTCTT CTGAATGGGC AGGAGTACTC AATGAACGAT 
GAAATGAAGG AAGCCTTCCA AAATGCCTAC TTAGAACTGG GAGGTCTGGG GGAACGTGTG 
CTAGGCTTCT GCTTCTTGAA TCTGCCTAGC AGCTTCTCCA AGGGATTCCC ATTTAATACA 
GATGAAATAA ATTTCCCCAT GGACAACCTT TGTTTTGTGG GCCTCATATC CATGATTGAC 
CCTCCCCGAG CTGCAGTGCC TGATGCTGTG AGCAAGTGTC GCAGTGCAGG AATTAAGGTG 
ATCATGGTAA CAGGAGATCA TCCCATTACA GCTAAGGCCA TTGCCAAGGG TGTGGGCATC 
ATCTCAGAAG GCACTGAGAC GGCAGAGGAA GTCGCTGCCC GGCTTAAGAT CCCTATCAGC 
AAGGTCGATG CCAGTGCTGC CAAAGCCATT GTGGTGCATG GTGCAGAACT GAAGGACATA 
CAGTCCAAGC AGCTTGATCA GATCCTCCAG AACCACCCTG AGATCGTGTT TGCTCGGACC 
TCCCCTCAGC AGAAGCTCAT CATTGTCGAG GGATGTCAGA GGCTGGGAGC CGTTGTGGCC 
GTGACAGGTG ACGGGGTGAA CGACTCCCCT GCGCTGAAGA AGGCTGACAT TGGCATTGCC 
ATGGGCATCT CTGGCTCTGA CGTCTCTAAG CAGGCAGCCG ACATGATCCT GCTGGATGAC 
AACTTTGCCT CCATCGTCAC GGGGGTGGAG GAGGGCCGCC TGATCTTTGA CAACCTGAAG 
AAATCCATCA TGTACACCCT GACCAGCAAC ATCCCCGAGA TCACGCCCTT CCTGATGTTC 
ATCATCCTCG GTATACCCCT GCCTCTGGGA ACCATAACCA TCCTCTGCAT TGATCTCGGC 
ACTGACATGG TCCCTGCCAT CTCCTTGGCT TATGAGTCAG CTGAAAGCGA CATCATGAAG 
AGGCTTCCAA GGAACCCAAA GACGGATAAT CTGGTGAACC ACCGTCTCAT TGGCATGGCC 
TATGGACAGA TTGGGATGAT CCAGGCTCTG GCTGGATTCT TTACCTACTT TGTAATCCTG 
GCTGAGAATG GTTTTAGGCC TGTTGATCTG CTGGGCATCC GCCTCCACTG GGAAGATAAA 
TACTTGAATG ACCTGGAGGA CAGCTACGGA CAGCAGTGGA CCTATGAGCA ACGAAAAGTT 
GTGGAGTTCA CATGCCAAAC GGCCTTTTTT GTCACCATCG TGGTTGTGCA GTGGGCGGAT 
CTCATCATCT CCAAGACTCG CCGCAACTCA CTTTTCCAGC AGGGCATGAG AAACAAAGTC 
TTAATATTTG GGATCCTGGA GGAGACACTC TTGGCTGCAT TTCTGTCCTA CACTCCAGGC 
ATGGACGTGG CCCTGCGAAT GTACCCACTC AAGATAACCT GGTGGCTCTG TGCCATTCCC 
TACAGTATTC TCATCTTCGT CTATGATGAA ATCAGAAAAC TCCTCATCCG TCAGCACCCG 
GATGGCTGGG TGGAAAGGGA GACGTACTAC TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ATP1A4 ( NM_144699.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_653300.2 Homo sapiens ATPase Na+/K+ transporting subunit alpha 4 (ATP1A4), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu30844
Clone ID Related Accession (Same CDS sequence)	NM_144699.3 , NM_144699.4
Accession Version	NM_144699.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3090bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-19
Organism	Homo sapiens(human)
Product	sodium/potassium-transporting ATPase subunit alpha-4 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB094047.1, BC094801.1, BC036052.1, BX647234.1, AL121987.34 and BC028297.1. On Aug 31, 2019 this sequence version replaced NM_144699.3. Transcript Variant: This variant (1) represents the longer transcript, and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BX647234.1, AF506797.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on manual assertion, conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGGGCTTT GGGGGAAGAA AGGGACAGTG GCTCCCCATG ACCAGAGTCC AAGACGAAGA 
CCTAAAAAAG GGCTTATCAA GAAAAAAATG GTGAAGAGGG AAAAACAGAA GCGCAATATG 
GAGGAACTGA AGAAGGAAGT GGTCATGGAT GATCACAAAT TAACCTTGGA AGAGCTGAGC 
ACCAAGTACT CCGTGGACCT GACAAAGGGC CATAGCCACC AAAGGGCAAA GGAAATCCTG 
ACTCGAGGTG GACCCAATAC TGTTACCCCA CCCCCCACCA CTCCAGAATG GGTCAAATTC 
TGTAAGCAAC TGTTCGGAGG CTTCTCCCTC CTACTATGGA CTGGGGCCAT TCTCTGCTTT 
GTGGCCTACA GCATCCAGAT ATATTTCAAT GAGGAGCCTA CCAAAGACAA CCTCTACCTG 
AGCATCGTAC TGTCCGTCGT GGTCATCGTC ACTGGCTGCT TCTCCTATTA TCAGGAGGCC 
AAGAGCTCCA AGATCATGGA GTCTTTTAAG AACATGGTGC CTCAGCAAGC TCTGGTAATT 
CGAGGAGGAG AGAAGATGCA AATTAATGTA CAAGAGGTGG TGTTGGGAGA CCTGGTGGAA 
ATCAAGGGTG GAGACCGAGT CCCTGCTGAC CTCCGGCTTA TCTCTGCACA AGGATGTAAG 
GTGGACAACT CATCCTTGAC TGGGGAGTCA GAACCCCAGA GCCGCTCCCC TGACTTCACC 
CATGAGAACC CTCTGGAGAC CCGAAACATC TGCTTCTTTT CCACCAACTG TGTGGAAGGA 
ACCGCCCGGG GTATTGTGAT TGCTACGGGA GACTCCACAG TGATGGGCAG AATTGCCTCC 
CTGACGTCAG GCCTGGCGGT TGGCCAGACA CCTATCGCTG CTGAGATCGA ACACTTCATC 
CATCTGATCA CTGTGGTGGC CGTCTTCCTT GGTGTCACTT TTTTTGCGCT CTCACTTCTC 
TTGGGCTATG GTTGGCTGGA GGCTATCATT TTTCTCATTG GCATCATTGT GGCCAATGTG 
CCTGAGGGGC TGTTGGCCAC AGTCACTGTG TGCCTGACCC TCACAGCCAA GCGCATGGCG 
CGGAAGAACT GCCTGGTGAA GAACCTGGAG GCGGTGGAGA CGCTGGGCTC CACGTCCACC 
ATCTGCTCAG ACAAGACGGG CACCCTCACC CAGAACCGCA TGACCGTCGC CCACATGTGG 
TTTGATATGA CCGTGTATGA GGCCGACACC ACTGAAGAAC AGACTGGAAA AACATTTACC 
AAGAGCTCTG ATACCTGGTT TATGCTGGCC CGAATCGCTG GCCTCTGCAA CCGGGCTGAC 
TTTAAGGCTA ATCAGGAGAT CCTGCCCATT GCTAAGAGGG CCACAACAGG TGATGCTTCC 
GAGTCAGCCC TCCTCAAGTT CATCGAGCAG TCTTACAGCT CTGTGGCGGA GATGAGAGAG 
AAAAACCCCA AGGTGGCAGA GATTCCCTTT AATTCTACCA ACAAGTACCA GATGTCCATC 
CACCTTCGGG AGGACAGCTC CCAGACCCAC GTACTGATGA TGAAGGGTGC TCCGGAGAGG 
ATCTTGGAGT TTTGTTCTAC CTTTCTTCTG AATGGGCAGG AGTACTCAAT GAACGATGAA 
ATGAAGGAAG CCTTCCAAAA TGCCTACTTA GAACTGGGAG GTCTGGGGGA ACGTGTGCTA 
GGCTTCTGCT TCTTGAATCT GCCTAGCAGC TTCTCCAAGG GATTCCCATT TAATACAGAT 
GAAATAAATT TCCCCATGGA CAACCTTTGT TTTGTGGGCC TCATATCCAT GATTGACCCT 
CCCCGAGCTG CAGTGCCTGA TGCTGTGAGC AAGTGTCGCA GTGCAGGAAT TAAGGTGATC 
ATGGTAACAG GAGATCATCC CATTACAGCT AAGGCCATTG CCAAGGGTGT GGGCATCATC 
TCAGAAGGCA CTGAGACGGC AGAGGAAGTC GCTGCCCGGC TTAAGATCCC TATCAGCAAG 
GTCGATGCCA GTGCTGCCAA AGCCATTGTG GTGCATGGTG CAGAACTGAA GGACATACAG 
TCCAAGCAGC TTGATCAGAT CCTCCAGAAC CACCCTGAGA TCGTGTTTGC TCGGACCTCC 
CCTCAGCAGA AGCTCATCAT TGTCGAGGGA TGTCAGAGGC TGGGAGCCGT TGTGGCCGTG 
ACAGGTGACG GGGTGAACGA CTCCCCTGCG CTGAAGAAGG CTGACATTGG CATTGCCATG 
GGCATCTCTG GCTCTGACGT CTCTAAGCAG GCAGCCGACA TGATCCTGCT GGATGACAAC 
TTTGCCTCCA TCGTCACGGG GGTGGAGGAG GGCCGCCTGA TCTTTGACAA CCTGAAGAAA 
TCCATCATGT ACACCCTGAC CAGCAACATC CCCGAGATCA CGCCCTTCCT GATGTTCATC 
ATCCTCGGTA TACCCCTGCC TCTGGGAACC ATAACCATCC TCTGCATTGA TCTCGGCACT 
GACATGGTCC CTGCCATCTC CTTGGCTTAT GAGTCAGCTG AAAGCGACAT CATGAAGAGG 
CTTCCAAGGA ACCCAAAGAC GGATAATCTG GTGAACCACC GTCTCATTGG CATGGCCTAT 
GGACAGATTG GGATGATCCA GGCTCTGGCT GGATTCTTTA CCTACTTTGT AATCCTGGCT 
GAGAATGGTT TTAGGCCTGT TGATCTGCTG GGCATCCGCC TCCACTGGGA AGATAAATAC 
TTGAATGACC TGGAGGACAG CTACGGACAG CAGTGGACCT ATGAGCAACG AAAAGTTGTG 
GAGTTCACAT GCCAAACGGC CTTTTTTGTC ACCATCGTGG TTGTGCAGTG GGCGGATCTC 
ATCATCTCCA AGACTCGCCG CAACTCACTT TTCCAGCAGG GCATGAGAAA CAAAGTCTTA 
ATATTTGGGA TCCTGGAGGA GACACTCTTG GCTGCATTTC TGTCCTACAC TCCAGGCATG 
GACGTGGCCC TGCGAATGTA CCCACTCAAG ATAACCTGGT GGCTCTGTGC CATTCCCTAC 
AGTATTCTCA TCTTCGTCTA TGATGAAATC AGAAAACTCC TCATCCGTCA GCACCCGGAT 
GGCTGGGTGG AAAGGGAGAC GTACTACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_653300.2
CDS	439..3528
Translation	MGLWGKKGTVAPHDQSPRRRPKKGLIKKKMVKREKQKRNMEELKKEVVMDDHKLTLEELSTKYSVDLTKGHSHQRAKEILTRGGPNTVTPPPTTPEWVKFCKQLFGGFSLLLWTGAILCFVAYSIQIYFNEEPTKDNLYLSIVLSVVVIVTGCFSYYQEAKSSKIMESFKNMVPQQALVIRGGEKMQINVQEVVLGDLVEIKGGDRVPADLRLISAQGCKVDNSSLTGESEPQSRSPDFTHENPLETRNICFFSTNCVEGTARGIVIATGDSTVMGRIASLTSGLAVGQTPIAAEIEHFIHLITVVAVFLGVTFFALSLLLGYGWLEAIIFLIGIIVANVPEGLLATVTVCLTLTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDMTVYEADTTEEQTGKTFTKSSDTWFMLARIAGLCNRADFKANQEILPIAKRATTGDASESALLKFIEQSYSSVAEMREKNPKVAEIPFNSTNKYQMSIHLREDSSQTHVLMMKGAPERILEFCSTFLLNGQEYSMNDEMKEAFQNAYLELGGLGERVLGFCFLNLPSSFSKGFPFNTDEINFPMDNLCFVGLISMIDPPRAAVPDAVSKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGTETAEEVAARLKIPISKVDASAAKAIVVHGAELKDIQSKQLDQILQNHPEIVFARTSPQQKLIIVEGCQRLGAVVAVTGDGVNDSPALKKADIGIAMGISGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIMYTLTSNIPEITPFLMFIILGIPLPLGTITILCIDLGTDMVPAISLAYESAESDIMKRLPRNPKTDNLVNHRLIGMAYGQIGMIQALAGFFTYFVILAENGFRPVDLLGIRLHWEDKYLNDLEDSYGQQWTYEQRKVVEFTCQTAFFVTIVVVQWADLIISKTRRNSLFQQGMRNKVLIFGILEETLLAAFLSYTPGMDVALRMYPLKITWWLCAIPYSILIFVYDEIRKLLIRQHPDGWVERETYY

Target ORF information:

RefSeq Version	NM_144699.4
Organism	Homo sapiens(human)
Definition	Homo sapiens ATPase Na+/K+ transporting subunit alpha 4 (ATP1A4), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_144699.4

ORF Insert Sequence:

ATGGGGCTTT GGGGGAAGAA AGGGACAGTG GCTCCCCATG ACCAGAGTCC AAGACGAAGA 
CCTAAAAAAG GGCTTATCAA GAAAAAAATG GTGAAGAGGG AAAAACAGAA GCGCAATATG 
GAGGAACTGA AGAAGGAAGT GGTCATGGAT GATCACAAAT TAACCTTGGA AGAGCTGAGC 
ACCAAGTACT CCGTGGACCT GACAAAGGGC CATAGCCACC AAAGGGCAAA GGAAATCCTG 
ACTCGAGGTG GACCCAATAC TGTTACCCCA CCCCCCACCA CTCCAGAATG GGTCAAATTC 
TGTAAGCAAC TGTTCGGAGG CTTCTCCCTC CTACTATGGA CTGGGGCCAT TCTCTGCTTT 
GTGGCCTACA GCATCCAGAT ATATTTCAAT GAGGAGCCTA CCAAAGACAA CCTCTACCTG 
AGCATCGTAC TGTCCGTCGT GGTCATCGTC ACTGGCTGCT TCTCCTATTA TCAGGAGGCC 
AAGAGCTCCA AGATCATGGA GTCTTTTAAG AACATGGTGC CTCAGCAAGC TCTGGTAATT 
CGAGGAGGAG AGAAGATGCA AATTAATGTA CAAGAGGTGG TGTTGGGAGA CCTGGTGGAA 
ATCAAGGGTG GAGACCGAGT CCCTGCTGAC CTCCGGCTTA TCTCTGCACA AGGATGTAAG 
GTGGACAACT CATCCTTGAC TGGGGAGTCA GAACCCCAGA GCCGCTCCCC TGACTTCACC 
CATGAGAACC CTCTGGAGAC CCGAAACATC TGCTTCTTTT CCACCAACTG TGTGGAAGGA 
ACCGCCCGGG GTATTGTGAT TGCTACGGGA GACTCCACAG TGATGGGCAG AATTGCCTCC 
CTGACGTCAG GCCTGGCGGT TGGCCAGACA CCTATCGCTG CTGAGATCGA ACACTTCATC 
CATCTGATCA CTGTGGTGGC CGTCTTCCTT GGTGTCACTT TTTTTGCGCT CTCACTTCTC 
TTGGGCTATG GTTGGCTGGA GGCTATCATT TTTCTCATTG GCATCATTGT GGCCAATGTG 
CCTGAGGGGC TGTTGGCCAC AGTCACTGTG TGCCTGACCC TCACAGCCAA GCGCATGGCG 
CGGAAGAACT GCCTGGTGAA GAACCTGGAG GCGGTGGAGA CGCTGGGCTC CACGTCCACC 
ATCTGCTCAG ACAAGACGGG CACCCTCACC CAGAACCGCA TGACCGTCGC CCACATGTGG 
TTTGATATGA CCGTGTATGA GGCCGACACC ACTGAAGAAC AGACTGGAAA AACATTTACC 
AAGAGCTCTG ATACCTGGTT TATGCTGGCC CGAATCGCTG GCCTCTGCAA CCGGGCTGAC 
TTTAAGGCTA ATCAGGAGAT CCTGCCCATT GCTAAGAGGG CCACAACAGG TGATGCTTCC 
GAGTCAGCCC TCCTCAAGTT CATCGAGCAG TCTTACAGCT CTGTGGCGGA GATGAGAGAG 
AAAAACCCCA AGGTGGCAGA GATTCCCTTT AATTCTACCA ACAAGTACCA GATGTCCATC 
CACCTTCGGG AGGACAGCTC CCAGACCCAC GTACTGATGA TGAAGGGTGC TCCGGAGAGG 
ATCTTGGAGT TTTGTTCTAC CTTTCTTCTG AATGGGCAGG AGTACTCAAT GAACGATGAA 
ATGAAGGAAG CCTTCCAAAA TGCCTACTTA GAACTGGGAG GTCTGGGGGA ACGTGTGCTA 
GGCTTCTGCT TCTTGAATCT GCCTAGCAGC TTCTCCAAGG GATTCCCATT TAATACAGAT 
GAAATAAATT TCCCCATGGA CAACCTTTGT TTTGTGGGCC TCATATCCAT GATTGACCCT 
CCCCGAGCTG CAGTGCCTGA TGCTGTGAGC AAGTGTCGCA GTGCAGGAAT TAAGGTGATC 
ATGGTAACAG GAGATCATCC CATTACAGCT AAGGCCATTG CCAAGGGTGT GGGCATCATC 
TCAGAAGGCA CTGAGACGGC AGAGGAAGTC GCTGCCCGGC TTAAGATCCC TATCAGCAAG 
GTCGATGCCA GTGCTGCCAA AGCCATTGTG GTGCATGGTG CAGAACTGAA GGACATACAG 
TCCAAGCAGC TTGATCAGAT CCTCCAGAAC CACCCTGAGA TCGTGTTTGC TCGGACCTCC 
CCTCAGCAGA AGCTCATCAT TGTCGAGGGA TGTCAGAGGC TGGGAGCCGT TGTGGCCGTG 
ACAGGTGACG GGGTGAACGA CTCCCCTGCG CTGAAGAAGG CTGACATTGG CATTGCCATG 
GGCATCTCTG GCTCTGACGT CTCTAAGCAG GCAGCCGACA TGATCCTGCT GGATGACAAC 
TTTGCCTCCA TCGTCACGGG GGTGGAGGAG GGCCGCCTGA TCTTTGACAA CCTGAAGAAA 
TCCATCATGT ACACCCTGAC CAGCAACATC CCCGAGATCA CGCCCTTCCT GATGTTCATC 
ATCCTCGGTA TACCCCTGCC TCTGGGAACC ATAACCATCC TCTGCATTGA TCTCGGCACT 
GACATGGTCC CTGCCATCTC CTTGGCTTAT GAGTCAGCTG AAAGCGACAT CATGAAGAGG 
CTTCCAAGGA ACCCAAAGAC GGATAATCTG GTGAACCACC GTCTCATTGG CATGGCCTAT 
GGACAGATTG GGATGATCCA GGCTCTGGCT GGATTCTTTA CCTACTTTGT AATCCTGGCT 
GAGAATGGTT TTAGGCCTGT TGATCTGCTG GGCATCCGCC TCCACTGGGA AGATAAATAC 
TTGAATGACC TGGAGGACAG CTACGGACAG CAGTGGACCT ATGAGCAACG AAAAGTTGTG 
GAGTTCACAT GCCAAACGGC CTTTTTTGTC ACCATCGTGG TTGTGCAGTG GGCGGATCTC 
ATCATCTCCA AGACTCGCCG CAACTCACTT TTCCAGCAGG GCATGAGAAA CAAAGTCTTA 
ATATTTGGGA TCCTGGAGGA GACACTCTTG GCTGCATTTC TGTCCTACAC TCCAGGCATG 
GACGTGGCCC TGCGAATGTA CCCACTCAAG ATAACCTGGT GGCTCTGTGC CATTCCCTAC 
AGTATTCTCA TCTTCGTCTA TGATGAAATC AGAAAACTCC TCATCCGTCA GCACCCGGAT 
GGCTGGGTGG AAAGGGAGAC GTACTACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ATP1A4 ( NM_144699.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_653300.2 Homo sapiens ATPase Na+/K+ transporting subunit alpha 4 (ATP1A4), transcript variant 1, mRNA.

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CloneID	OHu30844
Clone ID Related Accession (Same CDS sequence)	NM_144699.3 , NM_144699.4
Accession Version	NM_144699.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3090bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-07-05
Organism	Homo sapiens(human)
Product	sodium/potassium-transporting ATPase subunit alpha-4 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB094047.1, BC094801.1, BC036052.1, BX647234.1, AL121987.34 and BC028297.1. On Jul 26, 2007 this sequence version replaced NM_144699.2. Transcript Variant: This variant (1) represents the longer transcript, and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BX647234.1, BC068570.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2148093 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on manual assertion, conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGGGCTTT GGGGGAAGAA AGGGACAGTG GCTCCCCATG ACCAGAGTCC AAGACGAAGA 
CCTAAAAAAG GGCTTATCAA GAAAAAAATG GTGAAGAGGG AAAAACAGAA GCGCAATATG 
GAGGAACTGA AGAAGGAAGT GGTCATGGAT GATCACAAAT TAACCTTGGA AGAGCTGAGC 
ACCAAGTACT CCGTGGACCT GACAAAGGGC CATAGCCACC AAAGGGCAAA GGAAATCCTG 
ACTCGAGGTG GACCCAATAC TGTTACCCCA CCCCCCACCA CTCCAGAATG GGTCAAATTC 
TGTAAGCAAC TGTTCGGAGG CTTCTCCCTC CTACTATGGA CTGGGGCCAT TCTCTGCTTT 
GTGGCCTACA GCATCCAGAT ATATTTCAAT GAGGAGCCTA CCAAAGACAA CCTCTACCTG 
AGCATCGTAC TGTCCGTCGT GGTCATCGTC ACTGGCTGCT TCTCCTATTA TCAGGAGGCC 
AAGAGCTCCA AGATCATGGA GTCTTTTAAG AACATGGTGC CTCAGCAAGC TCTGGTAATT 
CGAGGAGGAG AGAAGATGCA AATTAATGTA CAAGAGGTGG TGTTGGGAGA CCTGGTGGAA 
ATCAAGGGTG GAGACCGAGT CCCTGCTGAC CTCCGGCTTA TCTCTGCACA AGGATGTAAG 
GTGGACAACT CATCCTTGAC TGGGGAGTCA GAACCCCAGA GCCGCTCCCC TGACTTCACC 
CATGAGAACC CTCTGGAGAC CCGAAACATC TGCTTCTTTT CCACCAACTG TGTGGAAGGA 
ACCGCCCGGG GTATTGTGAT TGCTACGGGA GACTCCACAG TGATGGGCAG AATTGCCTCC 
CTGACGTCAG GCCTGGCGGT TGGCCAGACA CCTATCGCTG CTGAGATCGA ACACTTCATC 
CATCTGATCA CTGTGGTGGC CGTCTTCCTT GGTGTCACTT TTTTTGCGCT CTCACTTCTC 
TTGGGCTATG GTTGGCTGGA GGCTATCATT TTTCTCATTG GCATCATTGT GGCCAATGTG 
CCTGAGGGGC TGTTGGCCAC AGTCACTGTG TGCCTGACCC TCACAGCCAA GCGCATGGCG 
CGGAAGAACT GCCTGGTGAA GAACCTGGAG GCGGTGGAGA CGCTGGGCTC CACGTCCACC 
ATCTGCTCAG ACAAGACGGG CACCCTCACC CAGAACCGCA TGACCGTCGC CCACATGTGG 
TTTGATATGA CCGTGTATGA GGCCGACACC ACTGAAGAAC AGACTGGAAA AACATTTACC 
AAGAGCTCTG ATACCTGGTT TATGCTGGCC CGAATCGCTG GCCTCTGCAA CCGGGCTGAC 
TTTAAGGCTA ATCAGGAGAT CCTGCCCATT GCTAAGAGGG CCACAACAGG TGATGCTTCC 
GAGTCAGCCC TCCTCAAGTT CATCGAGCAG TCTTACAGCT CTGTGGCGGA GATGAGAGAG 
AAAAACCCCA AGGTGGCAGA GATTCCCTTT AATTCTACCA ACAAGTACCA GATGTCCATC 
CACCTTCGGG AGGACAGCTC CCAGACCCAC GTACTGATGA TGAAGGGTGC TCCGGAGAGG 
ATCTTGGAGT TTTGTTCTAC CTTTCTTCTG AATGGGCAGG AGTACTCAAT GAACGATGAA 
ATGAAGGAAG CCTTCCAAAA TGCCTACTTA GAACTGGGAG GTCTGGGGGA ACGTGTGCTA 
GGCTTCTGCT TCTTGAATCT GCCTAGCAGC TTCTCCAAGG GATTCCCATT TAATACAGAT 
GAAATAAATT TCCCCATGGA CAACCTTTGT TTTGTGGGCC TCATATCCAT GATTGACCCT 
CCCCGAGCTG CAGTGCCTGA TGCTGTGAGC AAGTGTCGCA GTGCAGGAAT TAAGGTGATC 
ATGGTAACAG GAGATCATCC CATTACAGCT AAGGCCATTG CCAAGGGTGT GGGCATCATC 
TCAGAAGGCA CTGAGACGGC AGAGGAAGTC GCTGCCCGGC TTAAGATCCC TATCAGCAAG 
GTCGATGCCA GTGCTGCCAA AGCCATTGTG GTGCATGGTG CAGAACTGAA GGACATACAG 
TCCAAGCAGC TTGATCAGAT CCTCCAGAAC CACCCTGAGA TCGTGTTTGC TCGGACCTCC 
CCTCAGCAGA AGCTCATCAT TGTCGAGGGA TGTCAGAGGC TGGGAGCCGT TGTGGCCGTG 
ACAGGTGACG GGGTGAACGA CTCCCCTGCG CTGAAGAAGG CTGACATTGG CATTGCCATG 
GGCATCTCTG GCTCTGACGT CTCTAAGCAG GCAGCCGACA TGATCCTGCT GGATGACAAC 
TTTGCCTCCA TCGTCACGGG GGTGGAGGAG GGCCGCCTGA TCTTTGACAA CCTGAAGAAA 
TCCATCATGT ACACCCTGAC CAGCAACATC CCCGAGATCA CGCCCTTCCT GATGTTCATC 
ATCCTCGGTA TACCCCTGCC TCTGGGAACC ATAACCATCC TCTGCATTGA TCTCGGCACT 
GACATGGTCC CTGCCATCTC CTTGGCTTAT GAGTCAGCTG AAAGCGACAT CATGAAGAGG 
CTTCCAAGGA ACCCAAAGAC GGATAATCTG GTGAACCACC GTCTCATTGG CATGGCCTAT 
GGACAGATTG GGATGATCCA GGCTCTGGCT GGATTCTTTA CCTACTTTGT AATCCTGGCT 
GAGAATGGTT TTAGGCCTGT TGATCTGCTG GGCATCCGCC TCCACTGGGA AGATAAATAC 
TTGAATGACC TGGAGGACAG CTACGGACAG CAGTGGACCT ATGAGCAACG AAAAGTTGTG 
GAGTTCACAT GCCAAACGGC CTTTTTTGTC ACCATCGTGG TTGTGCAGTG GGCGGATCTC 
ATCATCTCCA AGACTCGCCG CAACTCACTT TTCCAGCAGG GCATGAGAAA CAAAGTCTTA 
ATATTTGGGA TCCTGGAGGA GACACTCTTG GCTGCATTTC TGTCCTACAC TCCAGGCATG 
GACGTGGCCC TGCGAATGTA CCCACTCAAG ATAACCTGGT GGCTCTGTGC CATTCCCTAC 
AGTATTCTCA TCTTCGTCTA TGATGAAATC AGAAAACTCC TCATCCGTCA GCACCCGGAT 
GGCTGGGTGG AAAGGGAGAC GTACTACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_653300.2
CDS	480..3569
Translation	MGLWGKKGTVAPHDQSPRRRPKKGLIKKKMVKREKQKRNMEELKKEVVMDDHKLTLEELSTKYSVDLTKGHSHQRAKEILTRGGPNTVTPPPTTPEWVKFCKQLFGGFSLLLWTGAILCFVAYSIQIYFNEEPTKDNLYLSIVLSVVVIVTGCFSYYQEAKSSKIMESFKNMVPQQALVIRGGEKMQINVQEVVLGDLVEIKGGDRVPADLRLISAQGCKVDNSSLTGESEPQSRSPDFTHENPLETRNICFFSTNCVEGTARGIVIATGDSTVMGRIASLTSGLAVGQTPIAAEIEHFIHLITVVAVFLGVTFFALSLLLGYGWLEAIIFLIGIIVANVPEGLLATVTVCLTLTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDMTVYEADTTEEQTGKTFTKSSDTWFMLARIAGLCNRADFKANQEILPIAKRATTGDASESALLKFIEQSYSSVAEMREKNPKVAEIPFNSTNKYQMSIHLREDSSQTHVLMMKGAPERILEFCSTFLLNGQEYSMNDEMKEAFQNAYLELGGLGERVLGFCFLNLPSSFSKGFPFNTDEINFPMDNLCFVGLISMIDPPRAAVPDAVSKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGTETAEEVAARLKIPISKVDASAAKAIVVHGAELKDIQSKQLDQILQNHPEIVFARTSPQQKLIIVEGCQRLGAVVAVTGDGVNDSPALKKADIGIAMGISGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIMYTLTSNIPEITPFLMFIILGIPLPLGTITILCIDLGTDMVPAISLAYESAESDIMKRLPRNPKTDNLVNHRLIGMAYGQIGMIQALAGFFTYFVILAENGFRPVDLLGIRLHWEDKYLNDLEDSYGQQWTYEQRKVVEFTCQTAFFVTIVVVQWADLIISKTRRNSLFQQGMRNKVLIFGILEETLLAAFLSYTPGMDVALRMYPLKITWWLCAIPYSILIFVYDEIRKLLIRQHPDGWVERETYY

Target ORF information:

RefSeq Version	NM_144699.3
Organism	Homo sapiens(human)
Definition	Homo sapiens ATPase Na+/K+ transporting subunit alpha 4 (ATP1A4), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_144699.3

ORF Insert Sequence:

ATGGGGCTTT GGGGGAAGAA AGGGACAGTG GCTCCCCATG ACCAGAGTCC AAGACGAAGA 
CCTAAAAAAG GGCTTATCAA GAAAAAAATG GTGAAGAGGG AAAAACAGAA GCGCAATATG 
GAGGAACTGA AGAAGGAAGT GGTCATGGAT GATCACAAAT TAACCTTGGA AGAGCTGAGC 
ACCAAGTACT CCGTGGACCT GACAAAGGGC CATAGCCACC AAAGGGCAAA GGAAATCCTG 
ACTCGAGGTG GACCCAATAC TGTTACCCCA CCCCCCACCA CTCCAGAATG GGTCAAATTC 
TGTAAGCAAC TGTTCGGAGG CTTCTCCCTC CTACTATGGA CTGGGGCCAT TCTCTGCTTT 
GTGGCCTACA GCATCCAGAT ATATTTCAAT GAGGAGCCTA CCAAAGACAA CCTCTACCTG 
AGCATCGTAC TGTCCGTCGT GGTCATCGTC ACTGGCTGCT TCTCCTATTA TCAGGAGGCC 
AAGAGCTCCA AGATCATGGA GTCTTTTAAG AACATGGTGC CTCAGCAAGC TCTGGTAATT 
CGAGGAGGAG AGAAGATGCA AATTAATGTA CAAGAGGTGG TGTTGGGAGA CCTGGTGGAA 
ATCAAGGGTG GAGACCGAGT CCCTGCTGAC CTCCGGCTTA TCTCTGCACA AGGATGTAAG 
GTGGACAACT CATCCTTGAC TGGGGAGTCA GAACCCCAGA GCCGCTCCCC TGACTTCACC 
CATGAGAACC CTCTGGAGAC CCGAAACATC TGCTTCTTTT CCACCAACTG TGTGGAAGGA 
ACCGCCCGGG GTATTGTGAT TGCTACGGGA GACTCCACAG TGATGGGCAG AATTGCCTCC 
CTGACGTCAG GCCTGGCGGT TGGCCAGACA CCTATCGCTG CTGAGATCGA ACACTTCATC 
CATCTGATCA CTGTGGTGGC CGTCTTCCTT GGTGTCACTT TTTTTGCGCT CTCACTTCTC 
TTGGGCTATG GTTGGCTGGA GGCTATCATT TTTCTCATTG GCATCATTGT GGCCAATGTG 
CCTGAGGGGC TGTTGGCCAC AGTCACTGTG TGCCTGACCC TCACAGCCAA GCGCATGGCG 
CGGAAGAACT GCCTGGTGAA GAACCTGGAG GCGGTGGAGA CGCTGGGCTC CACGTCCACC 
ATCTGCTCAG ACAAGACGGG CACCCTCACC CAGAACCGCA TGACCGTCGC CCACATGTGG 
TTTGATATGA CCGTGTATGA GGCCGACACC ACTGAAGAAC AGACTGGAAA AACATTTACC 
AAGAGCTCTG ATACCTGGTT TATGCTGGCC CGAATCGCTG GCCTCTGCAA CCGGGCTGAC 
TTTAAGGCTA ATCAGGAGAT CCTGCCCATT GCTAAGAGGG CCACAACAGG TGATGCTTCC 
GAGTCAGCCC TCCTCAAGTT CATCGAGCAG TCTTACAGCT CTGTGGCGGA GATGAGAGAG 
AAAAACCCCA AGGTGGCAGA GATTCCCTTT AATTCTACCA ACAAGTACCA GATGTCCATC 
CACCTTCGGG AGGACAGCTC CCAGACCCAC GTACTGATGA TGAAGGGTGC TCCGGAGAGG 
ATCTTGGAGT TTTGTTCTAC CTTTCTTCTG AATGGGCAGG AGTACTCAAT GAACGATGAA 
ATGAAGGAAG CCTTCCAAAA TGCCTACTTA GAACTGGGAG GTCTGGGGGA ACGTGTGCTA 
GGCTTCTGCT TCTTGAATCT GCCTAGCAGC TTCTCCAAGG GATTCCCATT TAATACAGAT 
GAAATAAATT TCCCCATGGA CAACCTTTGT TTTGTGGGCC TCATATCCAT GATTGACCCT 
CCCCGAGCTG CAGTGCCTGA TGCTGTGAGC AAGTGTCGCA GTGCAGGAAT TAAGGTGATC 
ATGGTAACAG GAGATCATCC CATTACAGCT AAGGCCATTG CCAAGGGTGT GGGCATCATC 
TCAGAAGGCA CTGAGACGGC AGAGGAAGTC GCTGCCCGGC TTAAGATCCC TATCAGCAAG 
GTCGATGCCA GTGCTGCCAA AGCCATTGTG GTGCATGGTG CAGAACTGAA GGACATACAG 
TCCAAGCAGC TTGATCAGAT CCTCCAGAAC CACCCTGAGA TCGTGTTTGC TCGGACCTCC 
CCTCAGCAGA AGCTCATCAT TGTCGAGGGA TGTCAGAGGC TGGGAGCCGT TGTGGCCGTG 
ACAGGTGACG GGGTGAACGA CTCCCCTGCG CTGAAGAAGG CTGACATTGG CATTGCCATG 
GGCATCTCTG GCTCTGACGT CTCTAAGCAG GCAGCCGACA TGATCCTGCT GGATGACAAC 
TTTGCCTCCA TCGTCACGGG GGTGGAGGAG GGCCGCCTGA TCTTTGACAA CCTGAAGAAA 
TCCATCATGT ACACCCTGAC CAGCAACATC CCCGAGATCA CGCCCTTCCT GATGTTCATC 
ATCCTCGGTA TACCCCTGCC TCTGGGAACC ATAACCATCC TCTGCATTGA TCTCGGCACT 
GACATGGTCC CTGCCATCTC CTTGGCTTAT GAGTCAGCTG AAAGCGACAT CATGAAGAGG 
CTTCCAAGGA ACCCAAAGAC GGATAATCTG GTGAACCACC GTCTCATTGG CATGGCCTAT 
GGACAGATTG GGATGATCCA GGCTCTGGCT GGATTCTTTA CCTACTTTGT AATCCTGGCT 
GAGAATGGTT TTAGGCCTGT TGATCTGCTG GGCATCCGCC TCCACTGGGA AGATAAATAC 
TTGAATGACC TGGAGGACAG CTACGGACAG CAGTGGACCT ATGAGCAACG AAAAGTTGTG 
GAGTTCACAT GCCAAACGGC CTTTTTTGTC ACCATCGTGG TTGTGCAGTG GGCGGATCTC 
ATCATCTCCA AGACTCGCCG CAACTCACTT TTCCAGCAGG GCATGAGAAA CAAAGTCTTA 
ATATTTGGGA TCCTGGAGGA GACACTCTTG GCTGCATTTC TGTCCTACAC TCCAGGCATG 
GACGTGGCCC TGCGAATGTA CCCACTCAAG ATAACCTGGT GGCTCTGTGC CATTCCCTAC 
AGTATTCTCA TCTTCGTCTA TGATGAAATC AGAAAACTCC TCATCCGTCA GCACCCGGAT 
GGCTGGGTGG AAAGGGAGAC GTACTACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Role of human Na,K-ATPase alpha 4 in sperm function, derived from studies in transgenic mice.
Molecular reproduction and development82(3)167-81(2015 Mar)
McDermott J,S?nchez G,Nangia AK,Blanco G

The transcription factor CREMtau and cAMP regulate promoter activity of the Na,K-ATPase alpha4 isoform.
Molecular reproduction and development73(11)1435-47(2006 Nov)
Rodova M,Nguyen AN,Blanco G

The human Na,K-ATPase alpha 4 isoform is a ouabain-sensitive alpha isoform that is expressed in sperm.
Molecular reproduction and development73(1)101-15(2006 Jan)
Hlivko JT,Chakraborty S,Hlivko TJ,Sengupta A,James PF

Biology, structure and mechanism of P-type ATPases.
Nature reviews. Molecular cell biology5(4)282-95(2004 Apr)
K?hlbrandt W

Functional roles of the alpha isoforms of the Na,K-ATPase.
Annals of the New York Academy of Sciences986354-9(2003 Apr)
Lingrel J,Moseley A,Dostanic I,Cougnon M,He S,James P,Woo A,O'Connor K,Neumann J

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ATP1A4 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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