ATP12A cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	ATP12A
Entrez Gene ID	479
Full Name	ATPase H+/K+ transporting non-gastric alpha2 subunit
Synonyms	ATP1AL1,HK
General protein information	Preferred Names ATPase H+/K+ transporting non-gastric alpha2 subunit Names potassium-transporting ATPase alpha chain 2 ATPase, H+/K+ transporting, nongastric, alpha polypeptide ATPase, Na+/K+ transporting, alpha polypeptide-like 1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 13 Map Location: 13q12.12\|13q12.1-q12.3
Summary	The protein encoded by this gene belongs to the family of P-type cation transport ATPases. This gene encodes a catalytic subunit of the ouabain-sensitive H+/K+ -ATPase that catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. It is also responsible for potassium absorption in various tissues. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010].
Disorder MIM:	182360

mRNA and Protein(s)

mRNA	Protein	Name
NM_001676.5	NP_001667.4	potassium-transporting ATPase alpha chain 2 isoform 2
NM_001676.6	NP_001667.4	potassium-transporting ATPase alpha chain 2 isoform 2
NM_001185085.1	NP_001172014.1	potassium-transporting ATPase alpha chain 2 isoform 1

Pathways from BioSystems

Homologies

Gallus gallus (chicken)	ATP12A	NP_001026080.1
Xenopus tropicalis (tropical clawed frog)	atp12a	NP_001025550.1
Canis lupus familiaris (dog)	ATP12A	XP_848278.2
Mus musculus (house mouse)	Atp12a	NP_619593.2
Bos taurus (cattle)	ATP12A	XP_002691916.2
Rattus norvegicus (Norway rat)	Atp12a	NP_598201.1
Homo sapiens (human)	ATP12A	NP_001172014.1
Pan troglodytes (chimpanzee)	ATP12A	XP_003314125.1
	LOC721488	XP_001117656.1

Gene Ontology
Bibliography

Related articles in PubMed

Airway acidification initiates host defense abnormalities in cystic fibrosis mice.
Shah VS, Meyerholz DK, Tang XX, Reznikov L, Abou Alaiwa M, Ernst SE, Karp PH, Wohlford-Lenane CL, Heilmann KP, Leidinger MR, Allen PD, Zabner J, McCray PB Jr, Ostedgaard LS, Stoltz DA, Randak CO, Welsh MJ
Science (New York, N.Y.)351(6272)503-7(2016 Jan)

Left ventricular diastolic function associated with common genetic variation in ATP12A in a general population.
Knez J, Salvi E, Tikhonoff V, Stolarz-Skrzypek K, Ryabikov A, Thijs L, Braga D, Kloch-Badelek M, Malyutina S, Casiglia E, Czarnecka D, Kawecka-Jaszcz K, Cusi D, Nawrot T, Staessen JA, Kuznetsova T
BMC medical genetics15121(2014 Nov)

The putative role of the non-gastric H?/K?-ATPase ATP12A (ATP1AL1) as anti-apoptotic ion transporter: effect of the H?/K? ATPase inhibitor SCH28080 on butyrate-stimulated myelomonocytic HL-60 cells.
Jakab M, Hofer S, Ravasio A, Huber F, Schmidt S, Hitzl W, Geibel JP, F?rst J, Ritter M
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology34(5)1507-26(2014)

Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
Comuzzie AG, Cole SA, Laston SL, Voruganti VS, Haack K, Gibbs RA, Butte NF
PloS one7(12)e51954(2012)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

expressing human ATP12A in cystic fibrosis mouse airways acidified airway surface liquid, impaired defenses, and increased airway bacteria.
Title: Airway acidification initiates host defense abnormalities in cystic fibrosis mice.

Genetic association studies show that carriers of ATP12A rs10507337 C allele or CCTTC haplotype had better pattern of myocardial relaxation as compared to non-carriers.
Title: Left ventricular diastolic function associated with common genetic variation in ATP12A in a general population.

No significantly different expression levels could be detected in the various disease states compared to normal tissue.
Title: Expression of the non-gastric H+/K+ ATPase ATP12A in normal and pathological human prostate tissue.

Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.

Use of fold recognition methods enables a prediction that the C-terminal domain of the beta subunits of Na,K-ATPase and H,K-ATPase has an immunoglobulin-like fold, which resembles cell adhesion molecules.
Title: A C-terminal lobe of the beta subunit of Na,K-ATPase and H,K-ATPase resembles cell adhesion molecules.

The following ATP12A gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ATP12A cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu04875	NM_001185085.1 Latest version!	Homo sapiens ATPase H+/K+ transporting non-gastric alpha2 subunit (ATP12A), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$399.50-$559.30 $799.00
OHu55771	NM_001676.6 Latest version!	Homo sapiens ATPase H+/K+ transporting non-gastric alpha2 subunit (ATP12A), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	20	$734.30 $1049.00
View Old Accession Versions >>
OHu55771	NM_001676.5	Homo sapiens ATPase H+/K+ transporting non-gastric alpha2 subunit (ATP12A), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	20	$734.30 $1049.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

ATP12A ( NM_001185085.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001172014.1 Homo sapiens ATPase H+/K+ transporting non-gastric alpha2 subunit (ATP12A), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu04875
Clone ID Related Accession (Same CDS sequence)	NM_001185085.1
Accession Version	NM_001185085.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3138bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-21
Organism	Homo sapiens(human)
Product	potassium-transporting ATPase alpha chain 2 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB216724.1, BC031609.1, AK303498.1, U02076.1 and CA450333.1. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC031609.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1968540, SAMEA1970526 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: full length.

ATGCACCAGA AAACCCCAGA AATTTACTCC GTGGAGCTCA GCGGAACTAA GGACATCGTG 
AAAACAGACA AGGGGGATGG CAAGGAGAAG TATAGGGGTC TGAAGAACAA CTGCCTGGAA 
CTCAAAAAGA AAAATCACAA AGAGGAGTTT CAGAAAGAAC TCCATCTGGA TGACCACAAA 
CTCAGCAATA GGGAATTGGA AGAGAAATAT GGCACAGACA TCATTATGGG TCTCTCCAGC 
ACCAGAGCTG CCGAGCTCCT GGCCCGGGAT GGGCCCAACT CCCTCACCCC TCCCAAGCAG 
ACGCCTGAGA TCGTCAAGTT CCTCAAGCAG ATGGTGGGGG GGTTCTCTAT CCTCCTGTGG 
GTGGGCGCCT TTCTCTGTTG GATTGCATAT GGGATTCAGT ACTCCAGCGA CAAGTCTGCA 
TCCCTGAACA ACGTGTACTT GGGCTGTGTG CTTGGTCTGG TGGTCATTTT AACGGGGATC 
TTTGCTTATT ACCAAGAGGC AAAAAGCACC AACATCATGT CCAGCTTCAA TAAGATGATC 
CCTCAGCAAG CTCTCGTCAT CCGAGATTCC GAGAAGAAGA CCATCCCTTC AGAGCAGCTG 
GTGGTGGGGG ACATTGTGGA GGTCAAAGGA GGAGACCAGA TCCCTGCAGA CATCAGGGTG 
CTGTCTTCTC AGGGGTGTCG GGTGGATAAC TCATCTCTCA CGGGGGAGTC TGAGCCCCAG 
CCCCGCTCCT CTGAGTTTAC CCATGAAAAC CCCCTGGAAA CAAAGAACAT CTGCTTCTAT 
TCCACAACGT GTCTGGAAGC ATCTACTTCC CCTGTAGGCA CTGTCACCGG CATGGTTATC 
AACACGGGTG ACCGCACCAT CATTGGCCAT ATTGCCTCAT TGGCCTCAGG AGTTGGAAAT 
GAGAAGACGC CCATTGCCAT TGAGATCGAG CACTTTGTTC ACATTGTGGC AGGAGTGGCT 
GTCTCCATCG GCATCCTTTT CTTCATCATC GCTGTGTCCC TGAAGTATCA AGTCCTGGAC 
TCCATCATCT TCCTCATTGG CATCATTGTG GCCAATGTGC CCGAGGGCCT CCTGGCCACT 
GTCACTGTGA CCCTGTCGCT GACAGCAAAA CGGATGGCCA AGAAGAACTG CCTGGTGAAG 
AACCTGGAGG CTGTGGAGAC CCTCGGCTCC ACCTCCATCA TCTGCTCGGA CAAGACTGGG 
ACACTGACCC AGAACAGGAT GACAGTGGCC CATCTGTGGT TCGACAATCA GATCTTTGTG 
GCTGACACCA GTGAGGACCA TTCAAACCAA GTCTTTGACC AAAGCTCTAG GACTTGGGCC 
TCCTTATCCA AGATAATAAC ATTGTGTAAC CGAGCAGAGT TCAAGCCAGG ACAGGAAAAT 
GTCCCCATCA TGAAGAAAGC TGTGATTGGA GATGCCTCAG AAACTGCTCT TTTAAAATTC 
TCAGAGGTCA TTTTGGGTGA TGTGATGGAA ATTAGAAAAA GAAACCGCAA AGTAGCTGAA 
ATCCCTTTTA ACTCTACTAA TAAATTTCAG CTCTCCATCC ACGAGATGGA TGACCCCCAC 
GGCAAGCGCT TCCTCATGGT GATGAAGGGG GCCCCTGAGC GCATCCTAGA GAAATGCAGC 
ACCATCATGA TCAACGGCGA GGAGCACCCA CTGGACAAGA GCACTGCCAA GACCTTCCAC 
ACAGCCTACA TGGAGCTGGG CGGGTTGGGC GAGCGTGTGC TGGGTTTCTG TCATCTCTAC 
CTGCCAGCAG ACGAGTTTCC AGAAACCTAC TCATTTGACA TAGACGCTAT GAACTTTCCG 
ACCTCCAACC TCTGTTTTGT GGGACTCTTG TCAATGATCG ATCCCCCTCG GTCCACCGTG 
CCAGATGCAG TCACCAAATG CCGGAGTGCA GGGATCAAGG TTATTATGGT TACTGGTGAT 
CATCCCATCA CAGCCAAAGC TATTGCCAAG AGTGTGGGGA TCATTTCAGC CAACAGTGAA 
ACAGTGGAAG ACATTGCACA TCGCCTCAAC ATTGCTGTGG AGCAAGTTAA CAAACGGGAT 
GCCAAGGCCG CTGTGGTGAC TGGCATGGAG CTGAAGGACA TGAGCTCAGA ACAGCTGGAT 
GAGATCTTAG CCAACTACCA GGAGATTGTC TTTGCCCGGA CATCCCCCCA GCAGAAGCTG 
ATCATTGTGG AGGGCTGTCA GAGGCAGGAT GCTGTTGTTG CTGTGACCGG GGATGGAGTT 
AATGACTCTC CGGCTCTAAA GAAGGCAGAC ATTGGGATTG CCATGGGGAT AGCAGGTTCT 
GATGCAGCCA AAAATGCAGC CGACATGGTC TTGCTGGACG ACAACTTCGC ATCCATCGTC 
ACAGGGGTGG AGGAAGGTCG CCTGATCTTT GACAACCTCA AGAAGACTAT TGCTTATTCC 
CTGACCAAGA ACATTGCCGA GCTGTGCCCC TTTCTGATCT ACATCATTGT CGGGCTCCCC 
CTGCCCATTG GCACCATCAC CATTCTGTTC ATTGACTTGG GGACAGACAT TATCCCCTCC 
ATTGCCTTGG CGTACGAGAA AGCTGAAAGT GACATCATGA ACAGGAAGCC TCGCCACAAG 
AATAAGGACA GGCTGGTGAA CCAGCCGCTC GCTGTGTACT CATACCTGCA CATTGGCCTC 
ATGCAAGCCC TGGGAGCTTT CCTTGTGTAT TTCACCGTCT ATGCACAAGA GGGCTTTCTG 
CCCCGCACTC TCATTAACCT GCGGGTAGAA TGGGAGAAGG ACTACGTGAA TGACTTGAAA 
GACAGCTATG GGCAGGAATG GACAAGGTAC CAGAGGGAAT ACCTAGAATG GACGGGCTAC 
ACGGCTTTCT TTGTTGGCAT CCTAGTCCAG CAAATAGCAG ATCTGATCAT CAGGAAAACC 
CGGAGGAATT CCATCTTCCA GCAGGGTCTC TTCAGAAATA AAGTCATCTG GGTGGGGATC 
ACCTCACAGA TCATCATTGG TCTGATCCTC TCCTATGGCC TCGGAAGTGT CACAGCCTTG 
AGTTTCACCA TGCTTAGGGC TCAGTACTGG TTTGTGGCTG TGCCGCACGC CATCCTGATC 
TGGGTGTATG ATGAGGTGCG GAAGCTCTTC ATCAGGCTCT ACCCTGGAAG CTGGTGGGAT 
AAGAACATGT ATTATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001172014.1
CDS	334..3471
Translation	MHQKTPEIYSVELSGTKDIVKTDKGDGKEKYRGLKNNCLELKKKNHKEEFQKELHLDDHKLSNRELEEKYGTDIIMGLSSTRAAELLARDGPNSLTPPKQTPEIVKFLKQMVGGFSILLWVGAFLCWIAYGIQYSSDKSASLNNVYLGCVLGLVVILTGIFAYYQEAKSTNIMSSFNKMIPQQALVIRDSEKKTIPSEQLVVGDIVEVKGGDQIPADIRVLSSQGCRVDNSSLTGESEPQPRSSEFTHENPLETKNICFYSTTCLEASTSPVGTVTGMVINTGDRTIIGHIASLASGVGNEKTPIAIEIEHFVHIVAGVAVSIGILFFIIAVSLKYQVLDSIIFLIGIIVANVPEGLLATVTVTLSLTAKRMAKKNCLVKNLEAVETLGSTSIICSDKTGTLTQNRMTVAHLWFDNQIFVADTSEDHSNQVFDQSSRTWASLSKIITLCNRAEFKPGQENVPIMKKAVIGDASETALLKFSEVILGDVMEIRKRNRKVAEIPFNSTNKFQLSIHEMDDPHGKRFLMVMKGAPERILEKCSTIMINGEEHPLDKSTAKTFHTAYMELGGLGERVLGFCHLYLPADEFPETYSFDIDAMNFPTSNLCFVGLLSMIDPPRSTVPDAVTKCRSAGIKVIMVTGDHPITAKAIAKSVGIISANSETVEDIAHRLNIAVEQVNKRDAKAAVVTGMELKDMSSEQLDEILANYQEIVFARTSPQQKLIIVEGCQRQDAVVAVTGDGVNDSPALKKADIGIAMGIAGSDAAKNAADMVLLDDNFASIVTGVEEGRLIFDNLKKTIAYSLTKNIAELCPFLIYIIVGLPLPIGTITILFIDLGTDIIPSIALAYEKAESDIMNRKPRHKNKDRLVNQPLAVYSYLHIGLMQALGAFLVYFTVYAQEGFLPRTLINLRVEWEKDYVNDLKDSYGQEWTRYQREYLEWTGYTAFFVGILVQQIADLIIRKTRRNSIFQQGLFRNKVIWVGITSQIIIGLILSYGLGSVTALSFTMLRAQYWFVAVPHAILIWVYDEVRKLFIRLYPGSWWDKNMYY

Target ORF information:

RefSeq Version	NM_001185085.1
Organism	Homo sapiens(human)
Definition	Homo sapiens ATPase H+/K+ transporting non-gastric alpha2 subunit (ATP12A), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001185085.1

ORF Insert Sequence:

ATGCACCAGA AAACCCCAGA AATTTACTCC GTGGAGCTCA GCGGAACTAA GGACATCGTG 
AAAACAGACA AGGGGGATGG CAAGGAGAAG TATAGGGGTC TGAAGAACAA CTGCCTGGAA 
CTCAAAAAGA AAAATCACAA AGAGGAGTTT CAGAAAGAAC TCCATCTGGA TGACCACAAA 
CTCAGCAATA GGGAATTGGA AGAGAAATAT GGCACAGACA TCATTATGGG TCTCTCCAGC 
ACCAGAGCTG CCGAGCTCCT GGCCCGGGAT GGGCCCAACT CCCTCACCCC TCCCAAGCAG 
ACGCCTGAGA TCGTCAAGTT CCTCAAGCAG ATGGTGGGGG GGTTCTCTAT CCTCCTGTGG 
GTGGGCGCCT TTCTCTGTTG GATTGCATAT GGGATTCAGT ACTCCAGCGA CAAGTCTGCA 
TCCCTGAACA ACGTGTACTT GGGCTGTGTG CTTGGTCTGG TGGTCATTTT AACGGGGATC 
TTTGCTTATT ACCAAGAGGC AAAAAGCACC AACATCATGT CCAGCTTCAA TAAGATGATC 
CCTCAGCAAG CTCTCGTCAT CCGAGATTCC GAGAAGAAGA CCATCCCTTC AGAGCAGCTG 
GTGGTGGGGG ACATTGTGGA GGTCAAAGGA GGAGACCAGA TCCCTGCAGA CATCAGGGTG 
CTGTCTTCTC AGGGGTGTCG GGTGGATAAC TCATCTCTCA CGGGGGAGTC TGAGCCCCAG 
CCCCGCTCCT CTGAGTTTAC CCATGAAAAC CCCCTGGAAA CAAAGAACAT CTGCTTCTAT 
TCCACAACGT GTCTGGAAGC ATCTACTTCC CCTGTAGGCA CTGTCACCGG CATGGTTATC 
AACACGGGTG ACCGCACCAT CATTGGCCAT ATTGCCTCAT TGGCCTCAGG AGTTGGAAAT 
GAGAAGACGC CCATTGCCAT TGAGATCGAG CACTTTGTTC ACATTGTGGC AGGAGTGGCT 
GTCTCCATCG GCATCCTTTT CTTCATCATC GCTGTGTCCC TGAAGTATCA AGTCCTGGAC 
TCCATCATCT TCCTCATTGG CATCATTGTG GCCAATGTGC CCGAGGGCCT CCTGGCCACT 
GTCACTGTGA CCCTGTCGCT GACAGCAAAA CGGATGGCCA AGAAGAACTG CCTGGTGAAG 
AACCTGGAGG CTGTGGAGAC CCTCGGCTCC ACCTCCATCA TCTGCTCGGA CAAGACTGGG 
ACACTGACCC AGAACAGGAT GACAGTGGCC CATCTGTGGT TCGACAATCA GATCTTTGTG 
GCTGACACCA GTGAGGACCA TTCAAACCAA GTCTTTGACC AAAGCTCTAG GACTTGGGCC 
TCCTTATCCA AGATAATAAC ATTGTGTAAC CGAGCAGAGT TCAAGCCAGG ACAGGAAAAT 
GTCCCCATCA TGAAGAAAGC TGTGATTGGA GATGCCTCAG AAACTGCTCT TTTAAAATTC 
TCAGAGGTCA TTTTGGGTGA TGTGATGGAA ATTAGAAAAA GAAACCGCAA AGTAGCTGAA 
ATCCCTTTTA ACTCTACTAA TAAATTTCAG CTCTCCATCC ACGAGATGGA TGACCCCCAC 
GGCAAGCGCT TCCTCATGGT GATGAAGGGG GCCCCTGAGC GCATCCTAGA GAAATGCAGC 
ACCATCATGA TCAACGGCGA GGAGCACCCA CTGGACAAGA GCACTGCCAA GACCTTCCAC 
ACAGCCTACA TGGAGCTGGG CGGGTTGGGC GAGCGTGTGC TGGGTTTCTG TCATCTCTAC 
CTGCCAGCAG ACGAGTTTCC AGAAACCTAC TCATTTGACA TAGACGCTAT GAACTTTCCG 
ACCTCCAACC TCTGTTTTGT GGGACTCTTG TCAATGATCG ATCCCCCTCG GTCCACCGTG 
CCAGATGCAG TCACCAAATG CCGGAGTGCA GGGATCAAGG TTATTATGGT TACTGGTGAT 
CATCCCATCA CAGCCAAAGC TATTGCCAAG AGTGTGGGGA TCATTTCAGC CAACAGTGAA 
ACAGTGGAAG ACATTGCACA TCGCCTCAAC ATTGCTGTGG AGCAAGTTAA CAAACGGGAT 
GCCAAGGCCG CTGTGGTGAC TGGCATGGAG CTGAAGGACA TGAGCTCAGA ACAGCTGGAT 
GAGATCTTAG CCAACTACCA GGAGATTGTC TTTGCCCGGA CATCCCCCCA GCAGAAGCTG 
ATCATTGTGG AGGGCTGTCA GAGGCAGGAT GCTGTTGTTG CTGTGACCGG GGATGGAGTT 
AATGACTCTC CGGCTCTAAA GAAGGCAGAC ATTGGGATTG CCATGGGGAT AGCAGGTTCT 
GATGCAGCCA AAAATGCAGC CGACATGGTC TTGCTGGACG ACAACTTCGC ATCCATCGTC 
ACAGGGGTGG AGGAAGGTCG CCTGATCTTT GACAACCTCA AGAAGACTAT TGCTTATTCC 
CTGACCAAGA ACATTGCCGA GCTGTGCCCC TTTCTGATCT ACATCATTGT CGGGCTCCCC 
CTGCCCATTG GCACCATCAC CATTCTGTTC ATTGACTTGG GGACAGACAT TATCCCCTCC 
ATTGCCTTGG CGTACGAGAA AGCTGAAAGT GACATCATGA ACAGGAAGCC TCGCCACAAG 
AATAAGGACA GGCTGGTGAA CCAGCCGCTC GCTGTGTACT CATACCTGCA CATTGGCCTC 
ATGCAAGCCC TGGGAGCTTT CCTTGTGTAT TTCACCGTCT ATGCACAAGA GGGCTTTCTG 
CCCCGCACTC TCATTAACCT GCGGGTAGAA TGGGAGAAGG ACTACGTGAA TGACTTGAAA 
GACAGCTATG GGCAGGAATG GACAAGGTAC CAGAGGGAAT ACCTAGAATG GACGGGCTAC 
ACGGCTTTCT TTGTTGGCAT CCTAGTCCAG CAAATAGCAG ATCTGATCAT CAGGAAAACC 
CGGAGGAATT CCATCTTCCA GCAGGGTCTC TTCAGAAATA AAGTCATCTG GGTGGGGATC 
ACCTCACAGA TCATCATTGG TCTGATCCTC TCCTATGGCC TCGGAAGTGT CACAGCCTTG 
AGTTTCACCA TGCTTAGGGC TCAGTACTGG TTTGTGGCTG TGCCGCACGC CATCCTGATC 
TGGGTGTATG ATGAGGTGCG GAAGCTCTTC ATCAGGCTCT ACCCTGGAAG CTGGTGGGAT 
AAGAACATGT ATTATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ATP12A ( NM_001676.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_001667.4 Homo sapiens ATPase H+/K+ transporting non-gastric alpha2 subunit (ATP12A), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu55771
Clone ID Related Accession (Same CDS sequence)	NM_001676.5 , NM_001676.6
Accession Version	NM_001676.5	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3120bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-21
Organism	Homo sapiens(human)
Product	potassium-transporting ATPase alpha chain 2 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB216724.1, U02076.1, AK303498.1 and CA450333.1. On Jun 3, 2010 this sequence version replaced NM_001676.4. Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK292968.1, U02076.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2142853 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

ATGCACCAGA AAACCCCAGA AATTTACTCC GTGGAGCTCA GCGGAACTAA GGACATCGTG 
AAAACAGACA AGGGGGATGG CAAGGAGAAG TATAGGGGTC TGAAGAACAA CTGCCTGGAA 
CTCAAAAAGA AAAATCACAA AGAGGAGTTT CAGAAAGAAC TCCATCTGGA TGACCACAAA 
CTCAGCAATA GGGAATTGGA AGAGAAATAT GGCACAGACA TCATTATGGG TCTCTCCAGC 
ACCAGAGCTG CCGAGCTCCT GGCCCGGGAT GGGCCCAACT CCCTCACCCC TCCCAAGCAG 
ACGCCTGAGA TCGTCAAGTT CCTCAAGCAG ATGGTGGGGG GGTTCTCTAT CCTCCTGTGG 
GTGGGCGCCT TTCTCTGTTG GATTGCATAT GGGATTCAGT ACTCCAGCGA CAAGTCTGCA 
TCCCTGAACA ACGTGTACTT GGGCTGTGTG CTTGGTCTGG TGGTCATTTT AACGGGGATC 
TTTGCTTATT ACCAAGAGGC AAAAAGCACC AACATCATGT CCAGCTTCAA TAAGATGATC 
CCTCAGCAAG CTCTCGTCAT CCGAGATTCC GAGAAGAAGA CCATCCCTTC AGAGCAGCTG 
GTGGTGGGGG ACATTGTGGA GGTCAAAGGA GGAGACCAGA TCCCTGCAGA CATCAGGGTG 
CTGTCTTCTC AGGGGTGTCG GGTGGATAAC TCATCTCTCA CGGGGGAGTC TGAGCCCCAG 
CCCCGCTCCT CTGAGTTTAC CCATGAAAAC CCCCTGGAAA CAAAGAACAT CTGCTTCTAT 
TCCACAACGT GTCTGGAAGG CACTGTCACC GGCATGGTTA TCAACACGGG TGACCGCACC 
ATCATTGGCC ATATTGCCTC ATTGGCCTCA GGAGTTGGAA ATGAGAAGAC GCCCATTGCC 
ATTGAGATCG AGCACTTTGT TCACATTGTG GCAGGAGTGG CTGTCTCCAT CGGCATCCTT 
TTCTTCATCA TCGCTGTGTC CCTGAAGTAT CAAGTCCTGG ACTCCATCAT CTTCCTCATT 
GGCATCATTG TGGCCAATGT GCCCGAGGGC CTCCTGGCCA CTGTCACTGT GACCCTGTCG 
CTGACAGCAA AACGGATGGC CAAGAAGAAC TGCCTGGTGA AGAACCTGGA GGCTGTGGAG 
ACCCTCGGCT CCACCTCCAT CATCTGCTCG GACAAGACTG GGACACTGAC CCAGAACAGG 
ATGACAGTGG CCCATCTGTG GTTCGACAAT CAGATCTTTG TGGCTGACAC CAGTGAGGAC 
CATTCAAACC AAGTCTTTGA CCAAAGCTCT AGGACTTGGG CCTCCTTATC CAAGATAATA 
ACATTGTGTA ACCGAGCAGA GTTCAAGCCA GGACAGGAAA ATGTCCCCAT CATGAAGAAA 
GCTGTGATTG GAGATGCCTC AGAAACTGCT CTTTTAAAAT TCTCAGAGGT CATTTTGGGT 
GATGTGATGG AAATTAGAAA AAGAAACCGC AAAGTAGCTG AAATCCCTTT TAACTCTACT 
AATAAATTTC AGCTCTCCAT CCACGAGATG GATGACCCCC ACGGCAAGCG CTTCCTCATG 
GTGATGAAGG GGGCCCCTGA GCGCATCCTA GAGAAATGCA GCACCATCAT GATCAACGGC 
GAGGAGCACC CACTGGACAA GAGCACTGCC AAGACCTTCC ACACAGCCTA CATGGAGCTG 
GGCGGGTTGG GCGAGCGTGT GCTGGGTTTC TGTCATCTCT ACCTGCCAGC AGACGAGTTT 
CCAGAAACCT ACTCATTTGA CATAGACGCT ATGAACTTTC CGACCTCCAA CCTCTGTTTT 
GTGGGACTCT TGTCAATGAT CGATCCCCCT CGGTCCACCG TGCCAGATGC AGTCACCAAA 
TGCCGGAGTG CAGGGATCAA GGTTATTATG GTTACTGGTG ATCATCCCAT CACAGCCAAA 
GCTATTGCCA AGAGTGTGGG GATCATTTCA GCCAACAGTG AAACAGTGGA AGACATTGCA 
CATCGCCTCA ACATTGCTGT GGAGCAAGTT AACAAACGGG ATGCCAAGGC CGCTGTGGTG 
ACTGGCATGG AGCTGAAGGA CATGAGCTCA GAACAGCTGG ATGAGATCTT AGCCAACTAC 
CAGGAGATTG TCTTTGCCCG GACATCCCCC CAGCAGAAGC TGATCATTGT GGAGGGCTGT 
CAGAGGCAGG ATGCTGTTGT TGCTGTGACC GGGGATGGAG TTAATGACTC TCCGGCTCTA 
AAGAAGGCAG ACATTGGGAT TGCCATGGGG ATAGCAGGTT CTGATGCAGC CAAAAATGCA 
GCCGACATGG TCTTGCTGGA CGACAACTTC GCATCCATCG TCACAGGGGT GGAGGAAGGT 
CGCCTGATCT TTGACAACCT CAAGAAGACT ATTGCTTATT CCCTGACCAA GAACATTGCC 
GAGCTGTGCC CCTTTCTGAT CTACATCATT GTCGGGCTCC CCCTGCCCAT TGGCACCATC 
ACCATTCTGT TCATTGACTT GGGGACAGAC ATTATCCCCT CCATTGCCTT GGCGTACGAG 
AAAGCTGAAA GTGACATCAT GAACAGGAAG CCTCGCCACA AGAATAAGGA CAGGCTGGTG 
AACCAGCCGC TCGCTGTGTA CTCATACCTG CACATTGGCC TCATGCAAGC CCTGGGAGCT 
TTCCTTGTGT ATTTCACCGT CTATGCACAA GAGGGCTTTC TGCCCCGCAC TCTCATTAAC 
CTGCGGGTAG AATGGGAGAA GGACTACGTG AATGACTTGA AAGACAGCTA TGGGCAGGAA 
TGGACAAGGT ACCAGAGGGA ATACCTAGAA TGGACGGGCT ACACGGCTTT CTTTGTTGGC 
ATCCTAGTCC AGCAAATAGC AGATCTGATC ATCAGGAAAA CCCGGAGGAA TTCCATCTTC 
CAGCAGGGTC TCTTCAGAAA TAAAGTCATC TGGGTGGGGA TCACCTCACA GATCATCATT 
GGTCTGATCC TCTCCTATGG CCTCGGAAGT GTCACAGCCT TGAGTTTCAC CATGCTTAGG 
GCTCAGTACT GGTTTGTGGC TGTGCCGCAC GCCATCCTGA TCTGGGTGTA TGATGAGGTG 
CGGAAGCTCT TCATCAGGCT CTACCCTGGA AGCTGGTGGG ATAAGAACAT GTATTATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001667.4
CDS	334..3453
Translation	MHQKTPEIYSVELSGTKDIVKTDKGDGKEKYRGLKNNCLELKKKNHKEEFQKELHLDDHKLSNRELEEKYGTDIIMGLSSTRAAELLARDGPNSLTPPKQTPEIVKFLKQMVGGFSILLWVGAFLCWIAYGIQYSSDKSASLNNVYLGCVLGLVVILTGIFAYYQEAKSTNIMSSFNKMIPQQALVIRDSEKKTIPSEQLVVGDIVEVKGGDQIPADIRVLSSQGCRVDNSSLTGESEPQPRSSEFTHENPLETKNICFYSTTCLEGTVTGMVINTGDRTIIGHIASLASGVGNEKTPIAIEIEHFVHIVAGVAVSIGILFFIIAVSLKYQVLDSIIFLIGIIVANVPEGLLATVTVTLSLTAKRMAKKNCLVKNLEAVETLGSTSIICSDKTGTLTQNRMTVAHLWFDNQIFVADTSEDHSNQVFDQSSRTWASLSKIITLCNRAEFKPGQENVPIMKKAVIGDASETALLKFSEVILGDVMEIRKRNRKVAEIPFNSTNKFQLSIHEMDDPHGKRFLMVMKGAPERILEKCSTIMINGEEHPLDKSTAKTFHTAYMELGGLGERVLGFCHLYLPADEFPETYSFDIDAMNFPTSNLCFVGLLSMIDPPRSTVPDAVTKCRSAGIKVIMVTGDHPITAKAIAKSVGIISANSETVEDIAHRLNIAVEQVNKRDAKAAVVTGMELKDMSSEQLDEILANYQEIVFARTSPQQKLIIVEGCQRQDAVVAVTGDGVNDSPALKKADIGIAMGIAGSDAAKNAADMVLLDDNFASIVTGVEEGRLIFDNLKKTIAYSLTKNIAELCPFLIYIIVGLPLPIGTITILFIDLGTDIIPSIALAYEKAESDIMNRKPRHKNKDRLVNQPLAVYSYLHIGLMQALGAFLVYFTVYAQEGFLPRTLINLRVEWEKDYVNDLKDSYGQEWTRYQREYLEWTGYTAFFVGILVQQIADLIIRKTRRNSIFQQGLFRNKVIWVGITSQIIIGLILSYGLGSVTALSFTMLRAQYWFVAVPHAILIWVYDEVRKLFIRLYPGSWWDKNMYY

Target ORF information:

RefSeq Version	NM_001676.5
Organism	Homo sapiens(human)
Definition	Homo sapiens ATPase H+/K+ transporting non-gastric alpha2 subunit (ATP12A), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001676.5

ORF Insert Sequence:

ATGCACCAGA AAACCCCAGA AATTTACTCC GTGGAGCTCA GCGGAACTAA GGACATCGTG 
AAAACAGACA AGGGGGATGG CAAGGAGAAG TATAGGGGTC TGAAGAACAA CTGCCTGGAA 
CTCAAAAAGA AAAATCACAA AGAGGAGTTT CAGAAAGAAC TCCATCTGGA TGACCACAAA 
CTCAGCAATA GGGAATTGGA AGAGAAATAT GGCACAGACA TCATTATGGG TCTCTCCAGC 
ACCAGAGCTG CCGAGCTCCT GGCCCGGGAT GGGCCCAACT CCCTCACCCC TCCCAAGCAG 
ACGCCTGAGA TCGTCAAGTT CCTCAAGCAG ATGGTGGGGG GGTTCTCTAT CCTCCTGTGG 
GTGGGCGCCT TTCTCTGTTG GATTGCATAT GGGATTCAGT ACTCCAGCGA CAAGTCTGCA 
TCCCTGAACA ACGTGTACTT GGGCTGTGTG CTTGGTCTGG TGGTCATTTT AACGGGGATC 
TTTGCTTATT ACCAAGAGGC AAAAAGCACC AACATCATGT CCAGCTTCAA TAAGATGATC 
CCTCAGCAAG CTCTCGTCAT CCGAGATTCC GAGAAGAAGA CCATCCCTTC AGAGCAGCTG 
GTGGTGGGGG ACATTGTGGA GGTCAAAGGA GGAGACCAGA TCCCTGCAGA CATCAGGGTG 
CTGTCTTCTC AGGGGTGTCG GGTGGATAAC TCATCTCTCA CGGGGGAGTC TGAGCCCCAG 
CCCCGCTCCT CTGAGTTTAC CCATGAAAAC CCCCTGGAAA CAAAGAACAT CTGCTTCTAT 
TCCACAACGT GTCTGGAAGG CACTGTCACC GGCATGGTTA TCAACACGGG TGACCGCACC 
ATCATTGGCC ATATTGCCTC ATTGGCCTCA GGAGTTGGAA ATGAGAAGAC GCCCATTGCC 
ATTGAGATCG AGCACTTTGT TCACATTGTG GCAGGAGTGG CTGTCTCCAT CGGCATCCTT 
TTCTTCATCA TCGCTGTGTC CCTGAAGTAT CAAGTCCTGG ACTCCATCAT CTTCCTCATT 
GGCATCATTG TGGCCAATGT GCCCGAGGGC CTCCTGGCCA CTGTCACTGT GACCCTGTCG 
CTGACAGCAA AACGGATGGC CAAGAAGAAC TGCCTGGTGA AGAACCTGGA GGCTGTGGAG 
ACCCTCGGCT CCACCTCCAT CATCTGCTCG GACAAGACTG GGACACTGAC CCAGAACAGG 
ATGACAGTGG CCCATCTGTG GTTCGACAAT CAGATCTTTG TGGCTGACAC CAGTGAGGAC 
CATTCAAACC AAGTCTTTGA CCAAAGCTCT AGGACTTGGG CCTCCTTATC CAAGATAATA 
ACATTGTGTA ACCGAGCAGA GTTCAAGCCA GGACAGGAAA ATGTCCCCAT CATGAAGAAA 
GCTGTGATTG GAGATGCCTC AGAAACTGCT CTTTTAAAAT TCTCAGAGGT CATTTTGGGT 
GATGTGATGG AAATTAGAAA AAGAAACCGC AAAGTAGCTG AAATCCCTTT TAACTCTACT 
AATAAATTTC AGCTCTCCAT CCACGAGATG GATGACCCCC ACGGCAAGCG CTTCCTCATG 
GTGATGAAGG GGGCCCCTGA GCGCATCCTA GAGAAATGCA GCACCATCAT GATCAACGGC 
GAGGAGCACC CACTGGACAA GAGCACTGCC AAGACCTTCC ACACAGCCTA CATGGAGCTG 
GGCGGGTTGG GCGAGCGTGT GCTGGGTTTC TGTCATCTCT ACCTGCCAGC AGACGAGTTT 
CCAGAAACCT ACTCATTTGA CATAGACGCT ATGAACTTTC CGACCTCCAA CCTCTGTTTT 
GTGGGACTCT TGTCAATGAT CGATCCCCCT CGGTCCACCG TGCCAGATGC AGTCACCAAA 
TGCCGGAGTG CAGGGATCAA GGTTATTATG GTTACTGGTG ATCATCCCAT CACAGCCAAA 
GCTATTGCCA AGAGTGTGGG GATCATTTCA GCCAACAGTG AAACAGTGGA AGACATTGCA 
CATCGCCTCA ACATTGCTGT GGAGCAAGTT AACAAACGGG ATGCCAAGGC CGCTGTGGTG 
ACTGGCATGG AGCTGAAGGA CATGAGCTCA GAACAGCTGG ATGAGATCTT AGCCAACTAC 
CAGGAGATTG TCTTTGCCCG GACATCCCCC CAGCAGAAGC TGATCATTGT GGAGGGCTGT 
CAGAGGCAGG ATGCTGTTGT TGCTGTGACC GGGGATGGAG TTAATGACTC TCCGGCTCTA 
AAGAAGGCAG ACATTGGGAT TGCCATGGGG ATAGCAGGTT CTGATGCAGC CAAAAATGCA 
GCCGACATGG TCTTGCTGGA CGACAACTTC GCATCCATCG TCACAGGGGT GGAGGAAGGT 
CGCCTGATCT TTGACAACCT CAAGAAGACT ATTGCTTATT CCCTGACCAA GAACATTGCC 
GAGCTGTGCC CCTTTCTGAT CTACATCATT GTCGGGCTCC CCCTGCCCAT TGGCACCATC 
ACCATTCTGT TCATTGACTT GGGGACAGAC ATTATCCCCT CCATTGCCTT GGCGTACGAG 
AAAGCTGAAA GTGACATCAT GAACAGGAAG CCTCGCCACA AGAATAAGGA CAGGCTGGTG 
AACCAGCCGC TCGCTGTGTA CTCATACCTG CACATTGGCC TCATGCAAGC CCTGGGAGCT 
TTCCTTGTGT ATTTCACCGT CTATGCACAA GAGGGCTTTC TGCCCCGCAC TCTCATTAAC 
CTGCGGGTAG AATGGGAGAA GGACTACGTG AATGACTTGA AAGACAGCTA TGGGCAGGAA 
TGGACAAGGT ACCAGAGGGA ATACCTAGAA TGGACGGGCT ACACGGCTTT CTTTGTTGGC 
ATCCTAGTCC AGCAAATAGC AGATCTGATC ATCAGGAAAA CCCGGAGGAA TTCCATCTTC 
CAGCAGGGTC TCTTCAGAAA TAAAGTCATC TGGGTGGGGA TCACCTCACA GATCATCATT 
GGTCTGATCC TCTCCTATGG CCTCGGAAGT GTCACAGCCT TGAGTTTCAC CATGCTTAGG 
GCTCAGTACT GGTTTGTGGC TGTGCCGCAC GCCATCCTGA TCTGGGTGTA TGATGAGGTG 
CGGAAGCTCT TCATCAGGCT CTACCCTGGA AGCTGGTGGG ATAAGAACAT GTATTATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ATP12A ( NM_001676.6 ) cDNA ORF clone, Homo sapiens(human) -> NP_001667.4 Homo sapiens ATPase H+/K+ transporting non-gastric alpha2 subunit (ATP12A), transcript variant 2, mRNA.

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CloneID	OHu55771
Clone ID Related Accession (Same CDS sequence)	NM_001676.5 , NM_001676.6
Accession Version	NM_001676.6 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3120bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-28
Organism	Homo sapiens(human)
Product	potassium-transporting ATPase alpha chain 2 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL157364.15, DB216724.1, U02076.1, AK303498.1 and CA450333.1. On Jun 2, 2019 this sequence version replaced NM_001676.5. Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U02076.1, AK292968.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2142853 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCACCAGA AAACCCCAGA AATTTACTCC GTGGAGCTCA GCGGAACTAA GGACATCGTG 
AAAACAGACA AGGGGGATGG CAAGGAGAAG TATAGGGGTC TGAAGAACAA CTGCCTGGAA 
CTCAAAAAGA AAAATCACAA AGAGGAGTTT CAGAAAGAAC TCCATCTGGA TGACCACAAA 
CTCAGCAATA GGGAATTGGA AGAGAAATAT GGCACAGACA TCATTATGGG TCTCTCCAGC 
ACCAGAGCTG CCGAGCTCCT GGCCCGGGAT GGGCCCAACT CCCTCACCCC TCCCAAGCAG 
ACGCCTGAGA TCGTCAAGTT CCTCAAGCAG ATGGTGGGGG GGTTCTCTAT CCTCCTGTGG 
GTGGGCGCCT TTCTCTGTTG GATTGCATAT GGGATTCAGT ACTCCAGCGA CAAGTCTGCA 
TCCCTGAACA ACGTGTACTT GGGCTGTGTG CTTGGTCTGG TGGTCATTTT AACGGGGATC 
TTTGCTTATT ACCAAGAGGC AAAAAGCACC AACATCATGT CCAGCTTCAA TAAGATGATC 
CCTCAGCAAG CTCTCGTCAT CCGAGATTCC GAGAAGAAGA CCATCCCTTC AGAGCAGCTG 
GTGGTGGGGG ACATTGTGGA GGTCAAAGGA GGAGACCAGA TCCCTGCAGA CATCAGGGTG 
CTGTCTTCTC AGGGGTGTCG GGTGGATAAC TCATCTCTCA CGGGGGAGTC TGAGCCCCAG 
CCCCGCTCCT CTGAGTTTAC CCATGAAAAC CCCCTGGAAA CAAAGAACAT CTGCTTCTAT 
TCCACAACGT GTCTGGAAGG CACTGTCACC GGCATGGTTA TCAACACGGG TGACCGCACC 
ATCATTGGCC ATATTGCCTC ATTGGCCTCA GGAGTTGGAA ATGAGAAGAC GCCCATTGCC 
ATTGAGATCG AGCACTTTGT TCACATTGTG GCAGGAGTGG CTGTCTCCAT CGGCATCCTT 
TTCTTCATCA TCGCTGTGTC CCTGAAGTAT CAAGTCCTGG ACTCCATCAT CTTCCTCATT 
GGCATCATTG TGGCCAATGT GCCCGAGGGC CTCCTGGCCA CTGTCACTGT GACCCTGTCG 
CTGACAGCAA AACGGATGGC CAAGAAGAAC TGCCTGGTGA AGAACCTGGA GGCTGTGGAG 
ACCCTCGGCT CCACCTCCAT CATCTGCTCG GACAAGACTG GGACACTGAC CCAGAACAGG 
ATGACAGTGG CCCATCTGTG GTTCGACAAT CAGATCTTTG TGGCTGACAC CAGTGAGGAC 
CATTCAAACC AAGTCTTTGA CCAAAGCTCT AGGACTTGGG CCTCCTTATC CAAGATAATA 
ACATTGTGTA ACCGAGCAGA GTTCAAGCCA GGACAGGAAA ATGTCCCCAT CATGAAGAAA 
GCTGTGATTG GAGATGCCTC AGAAACTGCT CTTTTAAAAT TCTCAGAGGT CATTTTGGGT 
GATGTGATGG AAATTAGAAA AAGAAACCGC AAAGTAGCTG AAATCCCTTT TAACTCTACT 
AATAAATTTC AGCTCTCCAT CCACGAGATG GATGACCCCC ACGGCAAGCG CTTCCTCATG 
GTGATGAAGG GGGCCCCTGA GCGCATCCTA GAGAAATGCA GCACCATCAT GATCAACGGC 
GAGGAGCACC CACTGGACAA GAGCACTGCC AAGACCTTCC ACACAGCCTA CATGGAGCTG 
GGCGGGTTGG GCGAGCGTGT GCTGGGTTTC TGTCATCTCT ACCTGCCAGC AGACGAGTTT 
CCAGAAACCT ACTCATTTGA CATAGACGCT ATGAACTTTC CGACCTCCAA CCTCTGTTTT 
GTGGGACTCT TGTCAATGAT CGATCCCCCT CGGTCCACCG TGCCAGATGC AGTCACCAAA 
TGCCGGAGTG CAGGGATCAA GGTTATTATG GTTACTGGTG ATCATCCCAT CACAGCCAAA 
GCTATTGCCA AGAGTGTGGG GATCATTTCA GCCAACAGTG AAACAGTGGA AGACATTGCA 
CATCGCCTCA ACATTGCTGT GGAGCAAGTT AACAAACGGG ATGCCAAGGC CGCTGTGGTG 
ACTGGCATGG AGCTGAAGGA CATGAGCTCA GAACAGCTGG ATGAGATCTT AGCCAACTAC 
CAGGAGATTG TCTTTGCCCG GACATCCCCC CAGCAGAAGC TGATCATTGT GGAGGGCTGT 
CAGAGGCAGG ATGCTGTTGT TGCTGTGACC GGGGATGGAG TTAATGACTC TCCGGCTCTA 
AAGAAGGCAG ACATTGGGAT TGCCATGGGG ATAGCAGGTT CTGATGCAGC CAAAAATGCA 
GCCGACATGG TCTTGCTGGA CGACAACTTC GCATCCATCG TCACAGGGGT GGAGGAAGGT 
CGCCTGATCT TTGACAACCT CAAGAAGACT ATTGCTTATT CCCTGACCAA GAACATTGCC 
GAGCTGTGCC CCTTTCTGAT CTACATCATT GTCGGGCTCC CCCTGCCCAT TGGCACCATC 
ACCATTCTGT TCATTGACTT GGGGACAGAC ATTATCCCCT CCATTGCCTT GGCGTACGAG 
AAAGCTGAAA GTGACATCAT GAACAGGAAG CCTCGCCACA AGAATAAGGA CAGGCTGGTG 
AACCAGCCGC TCGCTGTGTA CTCATACCTG CACATTGGCC TCATGCAAGC CCTGGGAGCT 
TTCCTTGTGT ATTTCACCGT CTATGCACAA GAGGGCTTTC TGCCCCGCAC TCTCATTAAC 
CTGCGGGTAG AATGGGAGAA GGACTACGTG AATGACTTGA AAGACAGCTA TGGGCAGGAA 
TGGACAAGGT ACCAGAGGGA ATACCTAGAA TGGACGGGCT ACACGGCTTT CTTTGTTGGC 
ATCCTAGTCC AGCAAATAGC AGATCTGATC ATCAGGAAAA CCCGGAGGAA TTCCATCTTC 
CAGCAGGGTC TCTTCAGAAA TAAAGTCATC TGGGTGGGGA TCACCTCACA GATCATCATT 
GGTCTGATCC TCTCCTATGG CCTCGGAAGT GTCACAGCCT TGAGTTTCAC CATGCTTAGG 
GCTCAGTACT GGTTTGTGGC TGTGCCGCAC GCCATCCTGA TCTGGGTGTA TGATGAGGTG 
CGGAAGCTCT TCATCAGGCT CTACCCTGGA AGCTGGTGGG ATAAGAACAT GTATTATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001667.4
CDS	337..3456
Translation	MHQKTPEIYSVELSGTKDIVKTDKGDGKEKYRGLKNNCLELKKKNHKEEFQKELHLDDHKLSNRELEEKYGTDIIMGLSSTRAAELLARDGPNSLTPPKQTPEIVKFLKQMVGGFSILLWVGAFLCWIAYGIQYSSDKSASLNNVYLGCVLGLVVILTGIFAYYQEAKSTNIMSSFNKMIPQQALVIRDSEKKTIPSEQLVVGDIVEVKGGDQIPADIRVLSSQGCRVDNSSLTGESEPQPRSSEFTHENPLETKNICFYSTTCLEGTVTGMVINTGDRTIIGHIASLASGVGNEKTPIAIEIEHFVHIVAGVAVSIGILFFIIAVSLKYQVLDSIIFLIGIIVANVPEGLLATVTVTLSLTAKRMAKKNCLVKNLEAVETLGSTSIICSDKTGTLTQNRMTVAHLWFDNQIFVADTSEDHSNQVFDQSSRTWASLSKIITLCNRAEFKPGQENVPIMKKAVIGDASETALLKFSEVILGDVMEIRKRNRKVAEIPFNSTNKFQLSIHEMDDPHGKRFLMVMKGAPERILEKCSTIMINGEEHPLDKSTAKTFHTAYMELGGLGERVLGFCHLYLPADEFPETYSFDIDAMNFPTSNLCFVGLLSMIDPPRSTVPDAVTKCRSAGIKVIMVTGDHPITAKAIAKSVGIISANSETVEDIAHRLNIAVEQVNKRDAKAAVVTGMELKDMSSEQLDEILANYQEIVFARTSPQQKLIIVEGCQRQDAVVAVTGDGVNDSPALKKADIGIAMGIAGSDAAKNAADMVLLDDNFASIVTGVEEGRLIFDNLKKTIAYSLTKNIAELCPFLIYIIVGLPLPIGTITILFIDLGTDIIPSIALAYEKAESDIMNRKPRHKNKDRLVNQPLAVYSYLHIGLMQALGAFLVYFTVYAQEGFLPRTLINLRVEWEKDYVNDLKDSYGQEWTRYQREYLEWTGYTAFFVGILVQQIADLIIRKTRRNSIFQQGLFRNKVIWVGITSQIIIGLILSYGLGSVTALSFTMLRAQYWFVAVPHAILIWVYDEVRKLFIRLYPGSWWDKNMYY

Target ORF information:

RefSeq Version	NM_001676.6
Organism	Homo sapiens(human)
Definition	Homo sapiens ATPase H+/K+ transporting non-gastric alpha2 subunit (ATP12A), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001676.6

ORF Insert Sequence:

ATGCACCAGA AAACCCCAGA AATTTACTCC GTGGAGCTCA GCGGAACTAA GGACATCGTG 
AAAACAGACA AGGGGGATGG CAAGGAGAAG TATAGGGGTC TGAAGAACAA CTGCCTGGAA 
CTCAAAAAGA AAAATCACAA AGAGGAGTTT CAGAAAGAAC TCCATCTGGA TGACCACAAA 
CTCAGCAATA GGGAATTGGA AGAGAAATAT GGCACAGACA TCATTATGGG TCTCTCCAGC 
ACCAGAGCTG CCGAGCTCCT GGCCCGGGAT GGGCCCAACT CCCTCACCCC TCCCAAGCAG 
ACGCCTGAGA TCGTCAAGTT CCTCAAGCAG ATGGTGGGGG GGTTCTCTAT CCTCCTGTGG 
GTGGGCGCCT TTCTCTGTTG GATTGCATAT GGGATTCAGT ACTCCAGCGA CAAGTCTGCA 
TCCCTGAACA ACGTGTACTT GGGCTGTGTG CTTGGTCTGG TGGTCATTTT AACGGGGATC 
TTTGCTTATT ACCAAGAGGC AAAAAGCACC AACATCATGT CCAGCTTCAA TAAGATGATC 
CCTCAGCAAG CTCTCGTCAT CCGAGATTCC GAGAAGAAGA CCATCCCTTC AGAGCAGCTG 
GTGGTGGGGG ACATTGTGGA GGTCAAAGGA GGAGACCAGA TCCCTGCAGA CATCAGGGTG 
CTGTCTTCTC AGGGGTGTCG GGTGGATAAC TCATCTCTCA CGGGGGAGTC TGAGCCCCAG 
CCCCGCTCCT CTGAGTTTAC CCATGAAAAC CCCCTGGAAA CAAAGAACAT CTGCTTCTAT 
TCCACAACGT GTCTGGAAGG CACTGTCACC GGCATGGTTA TCAACACGGG TGACCGCACC 
ATCATTGGCC ATATTGCCTC ATTGGCCTCA GGAGTTGGAA ATGAGAAGAC GCCCATTGCC 
ATTGAGATCG AGCACTTTGT TCACATTGTG GCAGGAGTGG CTGTCTCCAT CGGCATCCTT 
TTCTTCATCA TCGCTGTGTC CCTGAAGTAT CAAGTCCTGG ACTCCATCAT CTTCCTCATT 
GGCATCATTG TGGCCAATGT GCCCGAGGGC CTCCTGGCCA CTGTCACTGT GACCCTGTCG 
CTGACAGCAA AACGGATGGC CAAGAAGAAC TGCCTGGTGA AGAACCTGGA GGCTGTGGAG 
ACCCTCGGCT CCACCTCCAT CATCTGCTCG GACAAGACTG GGACACTGAC CCAGAACAGG 
ATGACAGTGG CCCATCTGTG GTTCGACAAT CAGATCTTTG TGGCTGACAC CAGTGAGGAC 
CATTCAAACC AAGTCTTTGA CCAAAGCTCT AGGACTTGGG CCTCCTTATC CAAGATAATA 
ACATTGTGTA ACCGAGCAGA GTTCAAGCCA GGACAGGAAA ATGTCCCCAT CATGAAGAAA 
GCTGTGATTG GAGATGCCTC AGAAACTGCT CTTTTAAAAT TCTCAGAGGT CATTTTGGGT 
GATGTGATGG AAATTAGAAA AAGAAACCGC AAAGTAGCTG AAATCCCTTT TAACTCTACT 
AATAAATTTC AGCTCTCCAT CCACGAGATG GATGACCCCC ACGGCAAGCG CTTCCTCATG 
GTGATGAAGG GGGCCCCTGA GCGCATCCTA GAGAAATGCA GCACCATCAT GATCAACGGC 
GAGGAGCACC CACTGGACAA GAGCACTGCC AAGACCTTCC ACACAGCCTA CATGGAGCTG 
GGCGGGTTGG GCGAGCGTGT GCTGGGTTTC TGTCATCTCT ACCTGCCAGC AGACGAGTTT 
CCAGAAACCT ACTCATTTGA CATAGACGCT ATGAACTTTC CGACCTCCAA CCTCTGTTTT 
GTGGGACTCT TGTCAATGAT CGATCCCCCT CGGTCCACCG TGCCAGATGC AGTCACCAAA 
TGCCGGAGTG CAGGGATCAA GGTTATTATG GTTACTGGTG ATCATCCCAT CACAGCCAAA 
GCTATTGCCA AGAGTGTGGG GATCATTTCA GCCAACAGTG AAACAGTGGA AGACATTGCA 
CATCGCCTCA ACATTGCTGT GGAGCAAGTT AACAAACGGG ATGCCAAGGC CGCTGTGGTG 
ACTGGCATGG AGCTGAAGGA CATGAGCTCA GAACAGCTGG ATGAGATCTT AGCCAACTAC 
CAGGAGATTG TCTTTGCCCG GACATCCCCC CAGCAGAAGC TGATCATTGT GGAGGGCTGT 
CAGAGGCAGG ATGCTGTTGT TGCTGTGACC GGGGATGGAG TTAATGACTC TCCGGCTCTA 
AAGAAGGCAG ACATTGGGAT TGCCATGGGG ATAGCAGGTT CTGATGCAGC CAAAAATGCA 
GCCGACATGG TCTTGCTGGA CGACAACTTC GCATCCATCG TCACAGGGGT GGAGGAAGGT 
CGCCTGATCT TTGACAACCT CAAGAAGACT ATTGCTTATT CCCTGACCAA GAACATTGCC 
GAGCTGTGCC CCTTTCTGAT CTACATCATT GTCGGGCTCC CCCTGCCCAT TGGCACCATC 
ACCATTCTGT TCATTGACTT GGGGACAGAC ATTATCCCCT CCATTGCCTT GGCGTACGAG 
AAAGCTGAAA GTGACATCAT GAACAGGAAG CCTCGCCACA AGAATAAGGA CAGGCTGGTG 
AACCAGCCGC TCGCTGTGTA CTCATACCTG CACATTGGCC TCATGCAAGC CCTGGGAGCT 
TTCCTTGTGT ATTTCACCGT CTATGCACAA GAGGGCTTTC TGCCCCGCAC TCTCATTAAC 
CTGCGGGTAG AATGGGAGAA GGACTACGTG AATGACTTGA AAGACAGCTA TGGGCAGGAA 
TGGACAAGGT ACCAGAGGGA ATACCTAGAA TGGACGGGCT ACACGGCTTT CTTTGTTGGC 
ATCCTAGTCC AGCAAATAGC AGATCTGATC ATCAGGAAAA CCCGGAGGAA TTCCATCTTC 
CAGCAGGGTC TCTTCAGAAA TAAAGTCATC TGGGTGGGGA TCACCTCACA GATCATCATT 
GGTCTGATCC TCTCCTATGG CCTCGGAAGT GTCACAGCCT TGAGTTTCAC CATGCTTAGG 
GCTCAGTACT GGTTTGTGGC TGTGCCGCAC GCCATCCTGA TCTGGGTGTA TGATGAGGTG 
CGGAAGCTCT TCATCAGGCT CTACCCTGGA AGCTGGTGGG ATAAGAACAT GTATTATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Airway acidification initiates host defense abnormalities in cystic fibrosis mice.
Science (New York, N.Y.)351(6272)503-7(2016 Jan)
Shah VS,Meyerholz DK,Tang XX,Reznikov L,Abou Alaiwa M,Ernst SE,Karp PH,Wohlford-Lenane CL,Heilmann KP,Leidinger MR,Allen PD,Zabner J,McCray PB Jr,Ostedgaard LS,Stoltz DA,Randak CO,Welsh MJ

Left ventricular diastolic function associated with common genetic variation in ATP12A in a general population.
BMC medical genetics15121(2014 Nov)
Knez J,Salvi E,Tikhonoff V,Stolarz-Skrzypek K,Ryabikov A,Thijs L,Braga D,Kloch-Badelek M,Malyutina S,Casiglia E,Czarnecka D,Kawecka-Jaszcz K,Cusi D,Nawrot T,Staessen JA,Kuznetsova T

The putative role of the non-gastric H?/K?-ATPase ATP12A (ATP1AL1) as anti-apoptotic ion transporter: effect of the H?/K? ATPase inhibitor SCH28080 on butyrate-stimulated myelomonocytic HL-60 cells.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology34(5)1507-26(2014)
Jakab M,Hofer S,Ravasio A,Huber F,Schmidt S,Hitzl W,Geibel JP,F?rst J,Ritter M

Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
PloS one7(12)e51954(2012)
Comuzzie AG,Cole SA,Laston SL,Voruganti VS,Haack K,Gibbs RA,Butte NF

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ATP12A cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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