NEUROG1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	NEUROG1
Entrez Gene ID	4762
Full Name	neurogenin 1
Synonyms	AKA,Math4C,NEUROD3,bHLHa6,ngn1
General protein information	Preferred Names neurogenin 1 Names neurogenin-1 NGN-1 class A basic helix-loop-helix protein 6 neurogenic basic-helix-loop-helix protein neurogenic differentiation 3 neurogenic differentiation factor 3
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 5 Map Location: 5q31.1
Disorder MIM:	601726

mRNA and Protein(s)

mRNA	Protein	Name
NM_006161.2	NP_006152.2	neurogenin-1
NM_006161.3	NP_006152.2	neurogenin-1

Pathways from BioSystems

Homologies

Bos taurus (cattle)	NEUROG1	XP_002689240.1
Mus musculus (house mouse)	Neurog1	NP_035026.1
Gallus gallus (chicken)	NEUROG1	NP_990214.1
	NEUROG1	XP_001110622.1
Canis lupus familiaris (dog)	NEUROG1	XP_538637.2
Homo sapiens (human)	NEUROG1	NP_006152.2
Rattus norvegicus (Norway rat)	Neurog1	NP_062080.1
Danio rerio (zebrafish)	neurog1	NP_571116.1
Xenopus tropicalis (tropical clawed frog)	neurog1	NP_001116895.1
Pan troglodytes (chimpanzee)	NEUROG1	XP_003310877.1

Gene Ontology
Bibliography

Related articles in PubMed

Induction of neuronal-like phenotype in human mesenchymal stem cells by overexpression of Neurogenin1 and treatment with neurotrophins.
Sch?ck L, Budde S, Lenarz T, Krettek C, Gross G, Windhagen H, Hoffmann A, Warnecke A
Tissue & cell48(5)524-32(2016 Oct)

The role of transcription factors of neurosensory cells in non-syndromic sensorineural hearing loss with or without inner ear malformation.
Zhou Y, Qing J, Dong Y, Nie J, Li J, Wang C, Liu Y, Peng T, Duan M, Liu X, Xie D
Acta oto-laryngologica136(3)277-82(2016)

Rapid neurogenesis through transcriptional activation in human stem cells.
Busskamp V, Lewis NE, Guye P, Ng AH, Shipman SL, Byrne SM, Sanjana NE, Murn J, Li Y, Li S, Stadler M, Weiss R, Church GM
Molecular systems biology10760(2014 Nov)

Methylation and microsatellite status and recurrence following adjuvant FOLFOX in colorectal cancer.
Han SW, Lee HJ, Bae JM, Cho NY, Lee KH, Kim TY, Oh DY, Im SA, Bang YJ, Jeong SY, Park KJ, Park JG, Kang GH, Kim TY
International journal of cancer132(9)2209-16(2013 May)

A boy with homozygous microdeletion of NEUROG1 presents with a congenital cranial dysinnervation disorder [Moebius syndrome variant].
Schr?der JC, L??ig AK, Galetzka D, Peters A, Castle JC, Diederich S, Zechner U, M?ller-Forell W, Keilmann A, Bartsch O
Behavioral and brain functions : BBF97(2013 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

NeuroD1 seemed not sufficient to induce and maintain neuronal differentiation. Induction of neuronal differentiation by overexpression of Neurog1 initiated important steps for the development of glutamatergic neurons such as the spiral ganglion neurons
Title: Induction of neuronal-like phenotype in human mesenchymal stem cells by overexpression of Neurogenin1 and treatment with neurotrophins.

mutation not found in group of children with sensorineural hearing loss
Title: The role of transcription factors of neurosensory cells in non-syndromic sensorineural hearing loss with or without inner ear malformation.

Results show that neurogenin-1 and -2 drive homogeneous differentiation of human stem cells into bipolar neurons in 4 days in defined media.
Title: Rapid neurogenesis through transcriptional activation in human stem cells.

Methylation of NEUROG1 is associated with recurrence following adjuvant FOLFOX in Stages II/III colorectal cancer.
Title: Methylation and microsatellite status and recurrence following adjuvant FOLFOX in colorectal cancer.

We propose NEUROG1 as a new gene for syndromic autosomal recessive hearing loss and congenital cranial dysinnervation disorder
Title: A boy with homozygous microdeletion of NEUROG1 presents with a congenital cranial dysinnervation disorder [Moebius syndrome variant].

The following NEUROG1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the NEUROG1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu29514	NM_006161.3 Latest version!	Homo sapiens neurogenin 1 (NEUROG1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu29514	NM_006161.2	Homo sapiens neurogenin 1 (NEUROG1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

NEUROG1 ( NM_006161.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_006152.2 Homo sapiens neurogenin 1 (NEUROG1), mRNA.

Price & Availability↑

CloneID	OHu29514
Clone ID Related Accession (Same CDS sequence)	NM_006161.2 , NM_006161.3
Accession Version	NM_006161.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 714bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-30
Organism	Homo sapiens(human)
Product	neurogenin-1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC028226.1. On Nov 20, 2003 this sequence version replaced NM_006161.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: BC028226.1 [ECO:0000345] ##Evidence-Data-END##

ATGCCAGCCC GCCTTGAGAC CTGCATCTCC GACCTCGACT GCGCCAGCAG CAGCGGCAGT 
GACCTATCCG GCTTCCTCAC CGACGAGGAA GACTGTGCCA GACTCCAACA GGCAGCCTCC 
GCTTCGGGGC CGCCCGCGCC GGCCCGCAGG GGCGCGCCCA ATATCTCCCG GGCGTCTGAG 
GTTCCAGGGG CACAGGACGA CGAGCAGGAG AGGCGGCGGC GCCGCGGCCG GACGCGGGTC 
CGCTCCGAGG CGCTGCTGCA CTCGCTGCGC AGGAGCCGGC GCGTCAAGGC CAACGATCGC 
GAGCGCAACC GCATGCACAA CTTGAACGCG GCCCTGGACG CACTGCGCAG CGTGCTGCCC 
TCGTTCCCCG ACGACACCAA GCTCACCAAA ATCGAGACGC TGCGCTTCGC CTACAACTAC 
ATCTGGGCTC TGGCCGAGAC ACTGCGCCTG GCGGATCAAG GGCTGCCCGG AGGCGGTGCC 
CGGGAGCGCC TCCTGCCGCC GCAGTGCGTC CCCTGCCTGC CCGGTCCCCC AAGCCCCGCC 
AGCGACGCGG AGTCCTGGGG CTCAGGTGCC GCCGCCGCCT CCCCGCTCTC TGACCCCAGT 
AGCCCAGCCG CCTCCGAAGA CTTCACCTAC CGCCCCGGCG ACCCTGTTTT CTCCTTCCCA 
AGCCTGCCCA AAGACTTGCT CCACACAACG CCCTGTTTCA TTCCTTACCA CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006152.2
CDS	260..973
Translation	MPARLETCISDLDCASSSGSDLSGFLTDEEDCARLQQAASASGPPAPARRGAPNISRASEVPGAQDDEQERRRRRGRTRVRSEALLHSLRRSRRVKANDRERNRMHNLNAALDALRSVLPSFPDDTKLTKIETLRFAYNYIWALAETLRLADQGLPGGGARERLLPPQCVPCLPGPPSPASDAESWGSGAAAASPLSDPSSPAASEDFTYRPGDPVFSFPSLPKDLLHTTPCFIPYH

Target ORF information:

RefSeq Version	NM_006161.2
Organism	Homo sapiens(human)
Definition	Homo sapiens neurogenin 1 (NEUROG1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006161.2

ORF Insert Sequence:

ATGCCAGCCC GCCTTGAGAC CTGCATCTCC GACCTCGACT GCGCCAGCAG CAGCGGCAGT 
GACCTATCCG GCTTCCTCAC CGACGAGGAA GACTGTGCCA GACTCCAACA GGCAGCCTCC 
GCTTCGGGGC CGCCCGCGCC GGCCCGCAGG GGCGCGCCCA ATATCTCCCG GGCGTCTGAG 
GTTCCAGGGG CACAGGACGA CGAGCAGGAG AGGCGGCGGC GCCGCGGCCG GACGCGGGTC 
CGCTCCGAGG CGCTGCTGCA CTCGCTGCGC AGGAGCCGGC GCGTCAAGGC CAACGATCGC 
GAGCGCAACC GCATGCACAA CTTGAACGCG GCCCTGGACG CACTGCGCAG CGTGCTGCCC 
TCGTTCCCCG ACGACACCAA GCTCACCAAA ATCGAGACGC TGCGCTTCGC CTACAACTAC 
ATCTGGGCTC TGGCCGAGAC ACTGCGCCTG GCGGATCAAG GGCTGCCCGG AGGCGGTGCC 
CGGGAGCGCC TCCTGCCGCC GCAGTGCGTC CCCTGCCTGC CCGGTCCCCC AAGCCCCGCC 
AGCGACGCGG AGTCCTGGGG CTCAGGTGCC GCCGCCGCCT CCCCGCTCTC TGACCCCAGT 
AGCCCAGCCG CCTCCGAAGA CTTCACCTAC CGCCCCGGCG ACCCTGTTTT CTCCTTCCCA 
AGCCTGCCCA AAGACTTGCT CCACACAACG CCCTGTTTCA TTCCTTACCA CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

NEUROG1 ( NM_006161.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_006152.2 Homo sapiens neurogenin 1 (NEUROG1), mRNA.

Price & Availability↑

CloneID	OHu29514
Clone ID Related Accession (Same CDS sequence)	NM_006161.2 , NM_006161.3
Accession Version	NM_006161.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 714bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-07-05
Organism	Homo sapiens(human)
Product	neurogenin-1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC005738.1 and BC028226.1. On Nov 23, 2018 this sequence version replaced NM_006161.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: BC028226.1, AB593107.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000314744.6/ ENSP00000317580.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCCAGCCC GCCTTGAGAC CTGCATCTCC GACCTCGACT GCGCCAGCAG CAGCGGCAGT 
GACCTATCCG GCTTCCTCAC CGACGAGGAA GACTGTGCCA GACTCCAACA GGCAGCCTCC 
GCTTCGGGGC CGCCCGCGCC GGCCCGCAGG GGCGCGCCCA ATATCTCCCG GGCGTCTGAG 
GTTCCAGGGG CACAGGACGA CGAGCAGGAG AGGCGGCGGC GCCGCGGCCG GACGCGGGTC 
CGCTCCGAGG CGCTGCTGCA CTCGCTGCGC AGGAGCCGGC GCGTCAAGGC CAACGATCGC 
GAGCGCAACC GCATGCACAA CTTGAACGCG GCCCTGGACG CACTGCGCAG CGTGCTGCCC 
TCGTTCCCCG ACGACACCAA GCTCACCAAA ATCGAGACGC TGCGCTTCGC CTACAACTAC 
ATCTGGGCTC TGGCCGAGAC ACTGCGCCTG GCGGATCAAG GGCTGCCCGG AGGCGGTGCC 
CGGGAGCGCC TCCTGCCGCC GCAGTGCGTC CCCTGCCTGC CCGGTCCCCC AAGCCCCGCC 
AGCGACGCGG AGTCCTGGGG CTCAGGTGCC GCCGCCGCCT CCCCGCTCTC TGACCCCAGT 
AGCCCAGCCG CCTCCGAAGA CTTCACCTAC CGCCCCGGCG ACCCTGTTTT CTCCTTCCCA 
AGCCTGCCCA AAGACTTGCT CCACACAACG CCCTGTTTCA TTCCTTACCA CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006152.2
CDS	275..988
Translation	MPARLETCISDLDCASSSGSDLSGFLTDEEDCARLQQAASASGPPAPARRGAPNISRASEVPGAQDDEQERRRRRGRTRVRSEALLHSLRRSRRVKANDRERNRMHNLNAALDALRSVLPSFPDDTKLTKIETLRFAYNYIWALAETLRLADQGLPGGGARERLLPPQCVPCLPGPPSPASDAESWGSGAAAASPLSDPSSPAASEDFTYRPGDPVFSFPSLPKDLLHTTPCFIPYH

Target ORF information:

RefSeq Version	NM_006161.3
Organism	Homo sapiens(human)
Definition	Homo sapiens neurogenin 1 (NEUROG1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006161.3

ORF Insert Sequence:

ATGCCAGCCC GCCTTGAGAC CTGCATCTCC GACCTCGACT GCGCCAGCAG CAGCGGCAGT 
GACCTATCCG GCTTCCTCAC CGACGAGGAA GACTGTGCCA GACTCCAACA GGCAGCCTCC 
GCTTCGGGGC CGCCCGCGCC GGCCCGCAGG GGCGCGCCCA ATATCTCCCG GGCGTCTGAG 
GTTCCAGGGG CACAGGACGA CGAGCAGGAG AGGCGGCGGC GCCGCGGCCG GACGCGGGTC 
CGCTCCGAGG CGCTGCTGCA CTCGCTGCGC AGGAGCCGGC GCGTCAAGGC CAACGATCGC 
GAGCGCAACC GCATGCACAA CTTGAACGCG GCCCTGGACG CACTGCGCAG CGTGCTGCCC 
TCGTTCCCCG ACGACACCAA GCTCACCAAA ATCGAGACGC TGCGCTTCGC CTACAACTAC 
ATCTGGGCTC TGGCCGAGAC ACTGCGCCTG GCGGATCAAG GGCTGCCCGG AGGCGGTGCC 
CGGGAGCGCC TCCTGCCGCC GCAGTGCGTC CCCTGCCTGC CCGGTCCCCC AAGCCCCGCC 
AGCGACGCGG AGTCCTGGGG CTCAGGTGCC GCCGCCGCCT CCCCGCTCTC TGACCCCAGT 
AGCCCAGCCG CCTCCGAAGA CTTCACCTAC CGCCCCGGCG ACCCTGTTTT CTCCTTCCCA 
AGCCTGCCCA AAGACTTGCT CCACACAACG CCCTGTTTCA TTCCTTACCA CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Induction of neuronal-like phenotype in human mesenchymal stem cells by overexpression of Neurogenin1 and treatment with neurotrophins.
Tissue & cell48(5)524-32(2016 Oct)
Sch?ck L,Budde S,Lenarz T,Krettek C,Gross G,Windhagen H,Hoffmann A,Warnecke A

The role of transcription factors of neurosensory cells in non-syndromic sensorineural hearing loss with or without inner ear malformation.
Acta oto-laryngologica136(3)277-82(2016)
Zhou Y,Qing J,Dong Y,Nie J,Li J,Wang C,Liu Y,Peng T,Duan M,Liu X,Xie D

Rapid neurogenesis through transcriptional activation in human stem cells.
Molecular systems biology10760(2014 Nov)
Busskamp V,Lewis NE,Guye P,Ng AH,Shipman SL,Byrne SM,Sanjana NE,Murn J,Li Y,Li S,Stadler M,Weiss R,Church GM

Methylation and microsatellite status and recurrence following adjuvant FOLFOX in colorectal cancer.
International journal of cancer132(9)2209-16(2013 May)
Han SW,Lee HJ,Bae JM,Cho NY,Lee KH,Kim TY,Oh DY,Im SA,Bang YJ,Jeong SY,Park KJ,Park JG,Kang GH,Kim TY

A boy with homozygous microdeletion of NEUROG1 presents with a congenital cranial dysinnervation disorder [Moebius syndrome variant].
Behavioral and brain functions : BBF97(2013 Feb)
Schr?der JC,L??ig AK,Galetzka D,Peters A,Castle JC,Diederich S,Zechner U,M?ller-Forell W,Keilmann A,Bartsch O

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NEUROG1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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