NDUFAB1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	NDUFAB1
Entrez Gene ID	4706
Full Name	NADH:ubiquinone oxidoreductase subunit AB1
Synonyms	ACP,ACP1,FASN2A,SDAP
General protein information	Preferred Names NADH:ubiquinone oxidoreductase subunit AB1 Names acyl carrier protein, mitochondrial CI-SDAP NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1, 8kDa NADH-ubiquinone oxidoreductase 9.6 kDa subunit NADH:ubiquinone oxidoreductase SDAP subunit complex I SDAP subunit mitochondrial acyl carrier protein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 16 Map Location: 16p12.2
Disorder MIM:	603836

mRNA and Protein(s)

mRNA	Protein	Name
NM_005003.2	NP_004994.1	acyl carrier protein, mitochondrial precursor
XM_011545856.2	XP_011544158.2	acyl carrier protein, mitochondrial isoform X1
NM_005003.3	NP_004994.1	acyl carrier protein, mitochondrial precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	NDUFAB1	NP_001065288.1
Bos taurus (cattle)	NDUFAB1	NP_001035578.1
Gallus gallus (chicken)	NDUFAB1	XP_004945320.1
Danio rerio (zebrafish)	ndufab1b	XP_005164154.1
Caenorhabditis elegans (roundworm)	Y56A3A.19	NP_499549.1
Rattus norvegicus (Norway rat)	Ndufab1	NP_001099764.1
Homo sapiens (human)	NDUFAB1	NP_004994.1
Mus musculus (house mouse)	LOC102634451	XP_006541434.1
Xenopus tropicalis (tropical clawed frog)	ndufab1	NP_001005125.1
	NDUFAB1	XP_001112404.1
Canis lupus familiaris (dog)	NDUFAB1	XP_536932.3
Mus musculus (house mouse)	Ndufab1	NP_082453.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP010464	XP_311483.3

Gene Ontology
Bibliography

Related articles in PubMed

Structures of the human mitochondrial ribosome in native states of assembly.
Brown A, Rathore S, Kimanius D, Aibara S, Bai XC, Rorbach J, Amunts A, Ramakrishnan V
Nature structural & molecular biology24(10)866-869(2017 Oct)

Accessory subunits are integral for assembly and function of human mitochondrial complex I.
Stroud DA, Surgenor EE, Formosa LE, Reljic B, Frazier AE, Dibley MG, Osellame LD, Stait T, Beilharz TH, Thorburn DR, Salim A, Ryan MT
Nature538(7623)123-126(2016 Oct)

Mitochondrial Protein Interaction Mapping Identifies Regulators of Respiratory Chain Function.
Floyd BJ, Wilkerson EM, Veling MT, Minogue CE, Xia C, Beebe ET, Wrobel RL, Cho H, Kremer LS, Alston CL, Gromek KA, Dolan BK, Ulbrich A, Stefely JA, Bohl SL, Werner KM, Jochem A, Westphall MS, Rensvold JW, Taylor RW, Prokisch H, Kim JP, Coon JJ, Pagliarini DJ
Molecular cell63(4)621-632(2016 Aug)

Mammalian ACSF3 protein is a malonyl-CoA synthetase that supplies the chain extender units for mitochondrial fatty acid synthesis.
Witkowski A, Thweatt J, Smith S
The Journal of biological chemistry286(39)33729-36(2011 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Observational study of gene-disease association. (HuGE Navigator)
Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.

Observational study of gene-disease association. (HuGE Navigator)
Title: Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects.

ACP has a dual role in mammalian mitochondrial function
Title: Down-regulation of mitochondrial acyl carrier protein in mammalian cells compromises protein lipoylation and respiratory complex I and results in cell death.

Observational study of gene-disease association. (HuGE Navigator)
Title: Oxidative stress, telomere length and biomarkers of physical aging in a cohort aged 79 years from the 1932 Scottish Mental Survey.

The p49/STRAP and NDUFAB1 proteins interacted and co-localized with each other in the cell.
Title: Identification of a subunit of NADH-dehydrogenase as a p49/STRAP-binding protein.

The following NDUFAB1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the NDUFAB1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu16181	NM_005003.3 Latest version!	Homo sapiens NADH:ubiquinone oxidoreductase subunit AB1 (NDUFAB1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu86046	XM_011545856.2 Latest version!	Homo sapiens NADH:ubiquinone oxidoreductase subunit AB1 (NDUFAB1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
View Old Accession Versions >>
OHu16181	NM_005003.2	Homo sapiens NADH:ubiquinone oxidoreductase subunit AB1 (NDUFAB1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

NDUFAB1 ( NM_005003.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_004994.1 Homo sapiens NADH:ubiquinone oxidoreductase subunit AB1 (NDUFAB1), mRNA.

Price & Availability↑

CloneID	OHu16181
Clone ID Related Accession (Same CDS sequence)	NM_005003.2 , NM_005003.3
Accession Version	NM_005003.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 471bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-25
Organism	Homo sapiens(human)
Product	acyl carrier protein, mitochondrial precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BI603093.1, BC058920.1 and AF087660.1. On Nov 22, 2018 this sequence version replaced NM_005003.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163657.6881.1, SRR5189655.145856.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2142680 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta MANE Ensembl match :: ENST00000007516.8/ ENSP00000007516.2 RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCGTCTC GTGTCCTTTC AGCCTATGTC AGCCGCCTGC CCGCGGCCTT TGCGCCGCTG 
CCCCGGGTCC GGATGCTGGC CGTGGCCCGG CCTCTCAGCA CCGCTCTCTG CTCCGCGGGG 
ACCCAGACGA GGCTCGGGAC TTTGCAGCCG GCCTTAGTGC TCGCGCAGGT TCCTGGTAGA 
GTTACACAGT TGTGCCGCCA GTATAGCGAC ATGCCTCCTT TGACGTTAGA GGGCATCCAG 
GACCGTGTTC TTTACGTATT GAAACTCTAT GACAAGATTG ACCCAGAGAA GCTTTCAGTA 
AATTCTCATT TTATGAAAGA CCTGGGCTTA GACAGTTTGG ACCAAGTGGA GATTATCATG 
GCCATGGAAG ACGAATTTGG GTTTGAAATT CCTGATATAG ATGCTGAAAA GTTAATGTGT 
CCACAAGAAA TTGTAGATTA CATTGCAGAT AAGAAGGATG TATATGAATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004994.1
CDS	27..497
Translation	MASRVLSAYVSRLPAAFAPLPRVRMLAVARPLSTALCSAGTQTRLGTLQPALVLAQVPGRVTQLCRQYSDMPPLTLEGIQDRVLYVLKLYDKIDPEKLSVNSHFMKDLGLDSLDQVEIIMAMEDEFGFEIPDIDAEKLMCPQEIVDYIADKKDVYE

Target ORF information:

RefSeq Version	NM_005003.3
Organism	Homo sapiens(human)
Definition	Homo sapiens NADH:ubiquinone oxidoreductase subunit AB1 (NDUFAB1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005003.3

ORF Insert Sequence:

ATGGCGTCTC GTGTCCTTTC AGCCTATGTC AGCCGCCTGC CCGCGGCCTT TGCGCCGCTG 
CCCCGGGTCC GGATGCTGGC CGTGGCCCGG CCTCTCAGCA CCGCTCTCTG CTCCGCGGGG 
ACCCAGACGA GGCTCGGGAC TTTGCAGCCG GCCTTAGTGC TCGCGCAGGT TCCTGGTAGA 
GTTACACAGT TGTGCCGCCA GTATAGCGAC ATGCCTCCTT TGACGTTAGA GGGCATCCAG 
GACCGTGTTC TTTACGTATT GAAACTCTAT GACAAGATTG ACCCAGAGAA GCTTTCAGTA 
AATTCTCATT TTATGAAAGA CCTGGGCTTA GACAGTTTGG ACCAAGTGGA GATTATCATG 
GCCATGGAAG ACGAATTTGG GTTTGAAATT CCTGATATAG ATGCTGAAAA GTTAATGTGT 
CCACAAGAAA TTGTAGATTA CATTGCAGAT AAGAAGGATG TATATGAATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

NDUFAB1 ( NM_005003.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_004994.1 Homo sapiens NADH:ubiquinone oxidoreductase subunit AB1 (NDUFAB1), mRNA.

Price & Availability↑

CloneID	OHu16181
Clone ID Related Accession (Same CDS sequence)	NM_005003.2 , NM_005003.3
Accession Version	NM_005003.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 471bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-30
Organism	Homo sapiens(human)
Product	acyl carrier protein, mitochondrial precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BI603093.1, BC058920.1 and AF087660.1. On Dec 12, 2003 this sequence version replaced NM_005003.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163655.424870.1, SRR1163658.383122.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2142680 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END##

ATGGCGTCTC GTGTCCTTTC AGCCTATGTC AGCCGCCTGC CCGCGGCCTT TGCGCCGCTG 
CCCCGGGTCC GGATGCTGGC CGTGGCCCGG CCTCTCAGCA CCGCTCTCTG CTCCGCGGGG 
ACCCAGACGA GGCTCGGGAC TTTGCAGCCG GCCTTAGTGC TCGCGCAGGT TCCTGGTAGA 
GTTACACAGT TGTGCCGCCA GTATAGCGAC ATGCCTCCTT TGACGTTAGA GGGCATCCAG 
GACCGTGTTC TTTACGTATT GAAACTCTAT GACAAGATTG ACCCAGAGAA GCTTTCAGTA 
AATTCTCATT TTATGAAAGA CCTGGGCTTA GACAGTTTGG ACCAAGTGGA GATTATCATG 
GCCATGGAAG ACGAATTTGG GTTTGAAATT CCTGATATAG ATGCTGAAAA GTTAATGTGT 
CCACAAGAAA TTGTAGATTA CATTGCAGAT AAGAAGGATG TATATGAATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004994.1
CDS	29..499
Translation	MASRVLSAYVSRLPAAFAPLPRVRMLAVARPLSTALCSAGTQTRLGTLQPALVLAQVPGRVTQLCRQYSDMPPLTLEGIQDRVLYVLKLYDKIDPEKLSVNSHFMKDLGLDSLDQVEIIMAMEDEFGFEIPDIDAEKLMCPQEIVDYIADKKDVYE

Target ORF information:

RefSeq Version	NM_005003.2
Organism	Homo sapiens(human)
Definition	Homo sapiens NADH:ubiquinone oxidoreductase subunit AB1 (NDUFAB1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005003.2

ORF Insert Sequence:

ATGGCGTCTC GTGTCCTTTC AGCCTATGTC AGCCGCCTGC CCGCGGCCTT TGCGCCGCTG 
CCCCGGGTCC GGATGCTGGC CGTGGCCCGG CCTCTCAGCA CCGCTCTCTG CTCCGCGGGG 
ACCCAGACGA GGCTCGGGAC TTTGCAGCCG GCCTTAGTGC TCGCGCAGGT TCCTGGTAGA 
GTTACACAGT TGTGCCGCCA GTATAGCGAC ATGCCTCCTT TGACGTTAGA GGGCATCCAG 
GACCGTGTTC TTTACGTATT GAAACTCTAT GACAAGATTG ACCCAGAGAA GCTTTCAGTA 
AATTCTCATT TTATGAAAGA CCTGGGCTTA GACAGTTTGG ACCAAGTGGA GATTATCATG 
GCCATGGAAG ACGAATTTGG GTTTGAAATT CCTGATATAG ATGCTGAAAA GTTAATGTGT 
CCACAAGAAA TTGTAGATTA CATTGCAGAT AAGAAGGATG TATATGAATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

NDUFAB1 ( XM_011545856.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011544158.2 Homo sapiens NADH:ubiquinone oxidoreductase subunit AB1 (NDUFAB1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu86046
Clone ID Related Accession (Same CDS sequence)	XM_011545856.2
Accession Version	XM_011545856.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 564bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	acyl carrier protein, mitochondrial isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000016.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011545856.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCGTCTC GTGTCCTTTC AGCCTATGTC AGCCGCCTGC CCGCGGCCTT TGCGCCGCTG 
CCCCGGGTCC GGATGCTGGC CGTGGCCCGG CCTCTCAGCA CCGCTCTCTG CTCCGCGGGG 
ACCCAGACGA GGCTCGGGAC TTTGCAGCCG GCCTTAGTGC TCGCGCAGGT GACTCGTGGT 
GACTTTGCTG CCGCTTGGCA AGGAGATCCA GTTAGAAGGA GCAGCAAGAC CTTCCAGGAG 
GCCATGCTGG AAGGACATGG GGTTCCTGGT AGAGTTACAC AGTTGTGCCG CCAGTATAGC 
GACATGCCTC CTTTGACGTT AGAGGGCATC CAGGACCGTG TTCTTTACGT ATTGAAACTC 
TATGACAAGA TTGACCCAGA GAAGCTTTCA GTAAATTCTC ATTTTATGAA AGACCTGGGC 
TTAGACAGTT TGGACCAAGT GGAGATTATC ATGGCCATGG AAGACGAATT TGGGTTTGAA 
ATTCCTGATA TAGATGCTGA AAAGTTAATG TGTCCACAAG AAATTGTAGA TTACATTGCA 
GATAAGAAGG ATGTATATGA ATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011544158.2
CDS	40..603
Translation	MASRVLSAYVSRLPAAFAPLPRVRMLAVARPLSTALCSAGTQTRLGTLQPALVLAQVTRGDFAAAWQGDPVRRSSKTFQEAMLEGHGVPGRVTQLCRQYSDMPPLTLEGIQDRVLYVLKLYDKIDPEKLSVNSHFMKDLGLDSLDQVEIIMAMEDEFGFEIPDIDAEKLMCPQEIVDYIADKKDVYE

Target ORF information:

RefSeq Version	XM_011545856.2
Organism	Homo sapiens(human)
Definition	Homo sapiens NADH:ubiquinone oxidoreductase subunit AB1 (NDUFAB1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011545856.2

ORF Insert Sequence:

ATGGCGTCTC GTGTCCTTTC AGCCTATGTC AGCCGCCTGC CCGCGGCCTT TGCGCCGCTG 
CCCCGGGTCC GGATGCTGGC CGTGGCCCGG CCTCTCAGCA CCGCTCTCTG CTCCGCGGGG 
ACCCAGACGA GGCTCGGGAC TTTGCAGCCG GCCTTAGTGC TCGCGCAGGT GACTCGTGGT 
GACTTTGCTG CCGCTTGGCA AGGAGATCCA GTTAGAAGGA GCAGCAAGAC CTTCCAGGAG 
GCCATGCTGG AAGGACATGG GGTTCCTGGT AGAGTTACAC AGTTGTGCCG CCAGTATAGC 
GACATGCCTC CTTTGACGTT AGAGGGCATC CAGGACCGTG TTCTTTACGT ATTGAAACTC 
TATGACAAGA TTGACCCAGA GAAGCTTTCA GTAAATTCTC ATTTTATGAA AGACCTGGGC 
TTAGACAGTT TGGACCAAGT GGAGATTATC ATGGCCATGG AAGACGAATT TGGGTTTGAA 
ATTCCTGATA TAGATGCTGA AAAGTTAATG TGTCCACAAG AAATTGTAGA TTACATTGCA 
GATAAGAAGG ATGTATATGA ATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Structures of the human mitochondrial ribosome in native states of assembly.
Nature structural & molecular biology24(10)866-869(2017 Oct)
Brown A,Rathore S,Kimanius D,Aibara S,Bai XC,Rorbach J,Amunts A,Ramakrishnan V

Accessory subunits are integral for assembly and function of human mitochondrial complex I.
Nature538(7623)123-126(2016 Oct)
Stroud DA,Surgenor EE,Formosa LE,Reljic B,Frazier AE,Dibley MG,Osellame LD,Stait T,Beilharz TH,Thorburn DR,Salim A,Ryan MT

Mitochondrial Protein Interaction Mapping Identifies Regulators of Respiratory Chain Function.
Molecular cell63(4)621-632(2016 Aug)
Floyd BJ,Wilkerson EM,Veling MT,Minogue CE,Xia C,Beebe ET,Wrobel RL,Cho H,Kremer LS,Alston CL,Gromek KA,Dolan BK,Ulbrich A,Stefely JA,Bohl SL,Werner KM,Jochem A,Westphall MS,Rensvold JW,Taylor RW,Prokisch H,Kim JP,Coon JJ,Pagliarini DJ

Mammalian ACSF3 protein is a malonyl-CoA synthetase that supplies the chain extender units for mitochondrial fatty acid synthesis.
The Journal of biological chemistry286(39)33729-36(2011 Sep)
Witkowski A,Thweatt J,Smith S

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NDUFAB1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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