MYL1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	MYL1
Entrez Gene ID	4632
Full Name	myosin light chain 1
Synonyms	MLC1F,MLC3F
General protein information	Preferred Names myosin light chain 1 Names myosin light chain 1/3, skeletal muscle isoform A1 catalytic A2 catalytic MLC1/MLC3 MLC1F/MLC3F myosin light chain A1/A2 myosin light chain alkali 1/2 myosin, light chain 1, alkali; skeletal, fast myosin, light polypeptide 1, alkali; skeletal, fast
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 2 Map Location: 2q34
Summary	Myosin is a hexameric ATPase cellular motor protein. It is composed of two heavy chains, two nonphosphorylatable alkali light chains, and two phosphorylatable regulatory light chains. This gene encodes a myosin alkali light chain expressed in fast skeletal muscle. Two transcript variants have been identified for this gene. [provided by RefSeq, Jul 2008].
Disorder MIM:	160780

mRNA and Protein(s)

mRNA	Protein	Name
NM_079422.3	NP_524146.1	myosin light chain 1/3, skeletal muscle isoform isoform 3f
NM_079422.2	NP_524146.1	myosin light chain 1/3, skeletal muscle isoform isoform 3f
NM_079420.2	NP_524144.1	myosin light chain 1/3, skeletal muscle isoform isoform 1f
NM_079420.3	NP_524144.1	myosin light chain 1/3, skeletal muscle isoform isoform 1f

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Myl1	NP_001071124.1
Pan troglodytes (chimpanzee)	MYL1	XP_516064.2
Canis lupus familiaris (dog)	MYL1	XP_005640670.1
Mus musculus (house mouse)	Myl1	NP_067260.1
Homo sapiens (human)	MYL1	NP_524144.1
Bos taurus (cattle)	MYL1	NP_001073046.1
Danio rerio (zebrafish)	myl1	NP_956294.1
Kluyveromyces lactis	KLLA0F10439g	XP_455555.1
Schizosaccharomyces pombe (fission yeast)	cdc4	NP_594947.1
Neurospora crassa	NCU06617	XP_962359.2
Danio rerio (zebrafish)	mylz3	NP_571694.1
Saccharomyces cerevisiae (baker's yeast)	MLC1	NP_011409.1
Magnaporthe oryzae (rice blast fungus)	MGG_09470	XP_003712281.1
Gallus gallus (chicken)	MYL1	NP_001038097.1
Eremothecium gossypii	AGOS_AFL030C	NP_985518.1
Xenopus tropicalis (tropical clawed frog)	myl1	NP_988954.1

Gene Ontology
Bibliography

Related articles in PubMed

Transient interaction between the N-terminal extension of the essential light chain-1 and motor domain of the myosin head during the ATPase cycle.
Logvinova DS, Matyushenko AM, Nikolaeva OP, Levitsky DI
Biochemical and biophysical research communications495(1)163-167(2018 01)

Myosin regulatory light chain phosphorylation is associated with leiomyosarcoma development.
Li HS, Lin Q, Wu J, Jiang ZH, Zhao JB, Pan J, He WQ, Zha JM
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie92810-818(2017 Aug)

Distinct sequences and post-translational modifications in cardiac atrial and ventricular myosin light chains revealed by top-down mass spectrometry.
Gregorich ZR, Cai W, Lin Z, Chen AJ, Peng Y, Kohmoto T, Ge Y
Journal of molecular and cellular cardiology10713-21(2017 Jun)

Intron polymorphism in MYL1 gene is associated with individual cardiac trainability to endurance training in human myocardium.
Lin X, Wang D, Wen L, Zhou S, Hu Y, Zhang Y
The Journal of sports medicine and physical fitness57(1-2)144-153(2017 Jan-Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These results support the concept of the ATP-induced transient interaction of the essential light chain-1 N-terminus with the motor domain of the myosin head.
Title: Transient interaction between the N-terminal extension of the essential light chain-1 and motor domain of the myosin head during the ATPase cycle.

polymorphism of intron MYL1 was associated with endurance performance, specifically in endurance trainability, but not genetic predisposition, in human adults.
Title: Intron polymorphism in MYL1 gene is associated with individual cardiac trainability to endurance training in human myocardium.

This study provides an additional mechanistic link between Angiotensin II and vasoconstriction via SFK-enhanced MLC phosphorylation in smooth muscle cells.
Title: Src Family Kinases (SFK) Mediate Angiotensin II-Induced Myosin Light Chain Phosphorylation and Hypertension.

MRK is a novel RhoC effector that controls LPA-stimulated cell invasion at least in part by regulating myosin dynamics, ERK and p38
Title: The MLK-related kinase (MRK) is a novel RhoC effector that mediates lysophosphatidic acid (LPA)-stimulated tumor cell invasion.

Disturbed myosin binding of mutated hVLC-1 may provide a pathomechanism for the development of hypertrohic cardiomyopathy.
Title: Mutations of ventricular essential myosin light chain disturb myosin binding and sarcomeric sorting.

The following MYL1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MYL1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu13487	NM_079422.3 Latest version!	Homo sapiens myosin light chain 1 (MYL1), transcript variant 3f, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu13342	NM_079420.3 Latest version!	Homo sapiens myosin light chain 1 (MYL1), transcript variant 1f, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
View Old Accession Versions >>
OHu13487	NM_079422.2	Homo sapiens myosin light chain 1 (MYL1), transcript variant 3f, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu13342	NM_079420.2	Homo sapiens myosin light chain 1 (MYL1), transcript variant 1f, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

MYL1 ( NM_079422.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_524146.1 Homo sapiens myosin light chain 1 (MYL1), transcript variant 3f, mRNA.

Price & Availability↑

CloneID	OHu13487
Clone ID Related Accession (Same CDS sequence)	NM_079422.3 , NM_079422.2
Accession Version	NM_079422.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 453bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-22
Organism	Homo sapiens(human)
Product	myosin light chain 1/3, skeletal muscle isoform isoform 3f
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC005318.1 and AA705167.1. On May 31, 2019 this sequence version replaced NM_079422.2. Transcript Variant: This variant (3f) encodes a protein that is 44 aa shorter than isoform 1f. Transcript variants 3f and 1f differ in their first two exons. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: DRR138525.50095.1, DRR138525.100254.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2162946 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

ATGTCCTTCA GTGCTGACCA GATTGCTGAA TTCAAGGAGG CATTTCTCCT GTTTGACAGA 
ACAGGTGATT CCAAGATCAC CTTAAGCCAG GTCGGTGATG TCCTTCGAGC TCTGGGCACA 
AATCCCACCA ATGCAGAGGT CAGGAAAGTT CTGGGAAACC CCAGCAATGA AGAGCTGAAT 
GCCAAGAAAA TTGAGTTTGA ACAATTTCTG CCTATGATGC AAGCCATTTC CAACAACAAG 
GACCAGGCCA CCTATGAAGA CTTTGTTGAG GGTCTGCGTG TCTTTGACAA GGAAGGCAAT 
GGCACAGTCA TGGGTGCTGA ACTCCGCCAT GTTCTAGCCA CCCTGGGTGA AAAGATGAAA 
GAGGAAGAAG TGGAAGCCCT GATGGCAGGT CAAGAAGACT CCAATGGCTG CATCAACTAC 
GAAGCTTTTG TCAAGCACAT CATGTCTATC TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_524146.1
CDS	72..524
Translation	MSFSADQIAEFKEAFLLFDRTGDSKITLSQVGDVLRALGTNPTNAEVRKVLGNPSNEELNAKKIEFEQFLPMMQAISNNKDQATYEDFVEGLRVFDKEGNGTVMGAELRHVLATLGEKMKEEEVEALMAGQEDSNGCINYEAFVKHIMSI

Target ORF information:

RefSeq Version	NM_079422.3
Organism	Homo sapiens(human)
Definition	Homo sapiens myosin light chain 1 (MYL1), transcript variant 3f, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_079422.3

ORF Insert Sequence:

ATGTCCTTCA GTGCTGACCA GATTGCTGAA TTCAAGGAGG CATTTCTCCT GTTTGACAGA 
ACAGGTGATT CCAAGATCAC CTTAAGCCAG GTCGGTGATG TCCTTCGAGC TCTGGGCACA 
AATCCCACCA ATGCAGAGGT CAGGAAAGTT CTGGGAAACC CCAGCAATGA AGAGCTGAAT 
GCCAAGAAAA TTGAGTTTGA ACAATTTCTG CCTATGATGC AAGCCATTTC CAACAACAAG 
GACCAGGCCA CCTATGAAGA CTTTGTTGAG GGTCTGCGTG TCTTTGACAA GGAAGGCAAT 
GGCACAGTCA TGGGTGCTGA ACTCCGCCAT GTTCTAGCCA CCCTGGGTGA AAAGATGAAA 
GAGGAAGAAG TGGAAGCCCT GATGGCAGGT CAAGAAGACT CCAATGGCTG CATCAACTAC 
GAAGCTTTTG TCAAGCACAT CATGTCTATC TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MYL1 ( NM_079422.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_524146.1 Homo sapiens myosin light chain 1 (MYL1), transcript variant 3f, mRNA.

Price & Availability↑

CloneID	OHu13487
Clone ID Related Accession (Same CDS sequence)	NM_079422.3 , NM_079422.2
Accession Version	NM_079422.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 453bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-16
Organism	Homo sapiens(human)
Product	myosin light chain 1/3, skeletal muscle isoform isoform 3f
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC005318.1 and AA705167.1. On Oct 4, 2006 this sequence version replaced NM_079422.1. Transcript Variant: This variant (3f) encodes a protein that is 44 aa shorter than isoform 1f. Transcript variants 3f and 1f differ in their first two exons. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC005318.1, BX436371.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2162946 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

ATGTCCTTCA GTGCTGACCA GATTGCTGAA TTCAAGGAGG CATTTCTCCT GTTTGACAGA 
ACAGGTGATT CCAAGATCAC CTTAAGCCAG GTCGGTGATG TCCTTCGAGC TCTGGGCACA 
AATCCCACCA ATGCAGAGGT CAGGAAAGTT CTGGGAAACC CCAGCAATGA AGAGCTGAAT 
GCCAAGAAAA TTGAGTTTGA ACAATTTCTG CCTATGATGC AAGCCATTTC CAACAACAAG 
GACCAGGCCA CCTATGAAGA CTTTGTTGAG GGTCTGCGTG TCTTTGACAA GGAAGGCAAT 
GGCACAGTCA TGGGTGCTGA ACTCCGCCAT GTTCTAGCCA CCCTGGGTGA AAAGATGAAA 
GAGGAAGAAG TGGAAGCCCT GATGGCAGGT CAAGAAGACT CCAATGGCTG CATCAACTAC 
GAAGCTTTTG TCAAGCACAT CATGTCTATC TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_524146.1
CDS	72..524
Translation	MSFSADQIAEFKEAFLLFDRTGDSKITLSQVGDVLRALGTNPTNAEVRKVLGNPSNEELNAKKIEFEQFLPMMQAISNNKDQATYEDFVEGLRVFDKEGNGTVMGAELRHVLATLGEKMKEEEVEALMAGQEDSNGCINYEAFVKHIMSI

Target ORF information:

RefSeq Version	NM_079422.2
Organism	Homo sapiens(human)
Definition	Homo sapiens myosin light chain 1 (MYL1), transcript variant 3f, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_079422.2

ORF Insert Sequence:

ATGTCCTTCA GTGCTGACCA GATTGCTGAA TTCAAGGAGG CATTTCTCCT GTTTGACAGA 
ACAGGTGATT CCAAGATCAC CTTAAGCCAG GTCGGTGATG TCCTTCGAGC TCTGGGCACA 
AATCCCACCA ATGCAGAGGT CAGGAAAGTT CTGGGAAACC CCAGCAATGA AGAGCTGAAT 
GCCAAGAAAA TTGAGTTTGA ACAATTTCTG CCTATGATGC AAGCCATTTC CAACAACAAG 
GACCAGGCCA CCTATGAAGA CTTTGTTGAG GGTCTGCGTG TCTTTGACAA GGAAGGCAAT 
GGCACAGTCA TGGGTGCTGA ACTCCGCCAT GTTCTAGCCA CCCTGGGTGA AAAGATGAAA 
GAGGAAGAAG TGGAAGCCCT GATGGCAGGT CAAGAAGACT CCAATGGCTG CATCAACTAC 
GAAGCTTTTG TCAAGCACAT CATGTCTATC TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MYL1 ( NM_079420.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_524144.1 Homo sapiens myosin light chain 1 (MYL1), transcript variant 1f, mRNA.

Price & Availability↑

CloneID	OHu13342
Clone ID Related Accession (Same CDS sequence)	NM_079420.2 , NM_079420.3
Accession Version	NM_079420.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 585bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	myosin light chain 1/3, skeletal muscle isoform isoform 1f
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA898482.1, CR456869.1 and AA705167.1. On Oct 4, 2006 this sequence version replaced NM_079420.1. Transcript Variant: This variant (1f) encodes a protein that is 44 aa longer than isoform 3f. Transcript variants 1f and 3f differ in their first two exons. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: ERR279835.5629.1, ERR279856.3421.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2162946 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

ATGGCACCAA AGAAAGACGT GAAGAAACCT GTGGCTGCGG CTGCGGCTGC CCCAGCCCCG 
GCACCGGCAC CTGCACCTGC CCCTGCCCCA GCCAAACCCA AAGAAGAAAA AATTGACCTC 
TCTGCCATTA AGATCGAGTT CTCTAAGGAA CAGCAGGATG AATTCAAGGA GGCATTTCTC 
CTGTTTGACA GAACAGGTGA TTCCAAGATC ACCTTAAGCC AGGTCGGTGA TGTCCTTCGA 
GCTCTGGGCA CAAATCCCAC CAATGCAGAG GTCAGGAAAG TTCTGGGAAA CCCCAGCAAT 
GAAGAGCTGA ATGCCAAGAA AATTGAGTTT GAACAATTTC TGCCTATGAT GCAAGCCATT 
TCCAACAACA AGGACCAGGC CACCTATGAA GACTTTGTTG AGGGTCTGCG TGTCTTTGAC 
AAGGAAGGCA ATGGCACAGT CATGGGTGCT GAACTCCGCC ATGTTCTAGC CACCCTGGGT 
GAAAAGATGA AAGAGGAAGA AGTGGAAGCC CTGATGGCAG GTCAAGAAGA CTCCAATGGC 
TGCATCAACT ACGAAGCTTT TGTCAAGCAC ATCATGTCTA TCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_524144.1
CDS	130..714
Translation	MAPKKDVKKPVAAAAAAPAPAPAPAPAPAPAKPKEEKIDLSAIKIEFSKEQQDEFKEAFLLFDRTGDSKITLSQVGDVLRALGTNPTNAEVRKVLGNPSNEELNAKKIEFEQFLPMMQAISNNKDQATYEDFVEGLRVFDKEGNGTVMGAELRHVLATLGEKMKEEEVEALMAGQEDSNGCINYEAFVKHIMSI

Target ORF information:

RefSeq Version	NM_079420.2
Organism	Homo sapiens(human)
Definition	Homo sapiens myosin light chain 1 (MYL1), transcript variant 1f, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_079420.2

ORF Insert Sequence:

ATGGCACCAA AGAAAGACGT GAAGAAACCT GTGGCTGCGG CTGCGGCTGC CCCAGCCCCG 
GCACCGGCAC CTGCACCTGC CCCTGCCCCA GCCAAACCCA AAGAAGAAAA AATTGACCTC 
TCTGCCATTA AGATCGAGTT CTCTAAGGAA CAGCAGGATG AATTCAAGGA GGCATTTCTC 
CTGTTTGACA GAACAGGTGA TTCCAAGATC ACCTTAAGCC AGGTCGGTGA TGTCCTTCGA 
GCTCTGGGCA CAAATCCCAC CAATGCAGAG GTCAGGAAAG TTCTGGGAAA CCCCAGCAAT 
GAAGAGCTGA ATGCCAAGAA AATTGAGTTT GAACAATTTC TGCCTATGAT GCAAGCCATT 
TCCAACAACA AGGACCAGGC CACCTATGAA GACTTTGTTG AGGGTCTGCG TGTCTTTGAC 
AAGGAAGGCA ATGGCACAGT CATGGGTGCT GAACTCCGCC ATGTTCTAGC CACCCTGGGT 
GAAAAGATGA AAGAGGAAGA AGTGGAAGCC CTGATGGCAG GTCAAGAAGA CTCCAATGGC 
TGCATCAACT ACGAAGCTTT TGTCAAGCAC ATCATGTCTA TCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MYL1 ( NM_079420.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_524144.1 Homo sapiens myosin light chain 1 (MYL1), transcript variant 1f, mRNA.

Price & Availability↑

CloneID	OHu13342
Clone ID Related Accession (Same CDS sequence)	NM_079420.2 , NM_079420.3
Accession Version	NM_079420.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 585bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	myosin light chain 1/3, skeletal muscle isoform isoform 1f
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC021150.9, DA898482.1, CR456869.1 and AA705167.1. On Nov 22, 2018 this sequence version replaced NM_079420.2. Transcript Variant: This variant (1f) encodes a protein that is 44 aa longer than isoform 3f. Transcript variants 1f and 3f differ in their first two exons. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: ERR279865.91.1, ERR279835.5629.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2162946 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000352451.4/ ENSP00000307280.4 RefSeq Select criteria :: based on conservation, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCACCAA AGAAAGACGT GAAGAAACCT GTGGCTGCGG CTGCGGCTGC CCCAGCCCCG 
GCACCGGCAC CTGCACCTGC CCCTGCCCCA GCCAAACCCA AAGAAGAAAA AATTGACCTC 
TCTGCCATTA AGATCGAGTT CTCTAAGGAA CAGCAGGATG AATTCAAGGA GGCATTTCTC 
CTGTTTGACA GAACAGGTGA TTCCAAGATC ACCTTAAGCC AGGTCGGTGA TGTCCTTCGA 
GCTCTGGGCA CAAATCCCAC CAATGCAGAG GTCAGGAAAG TTCTGGGAAA CCCCAGCAAT 
GAAGAGCTGA ATGCCAAGAA AATTGAGTTT GAACAATTTC TGCCTATGAT GCAAGCCATT 
TCCAACAACA AGGACCAGGC CACCTATGAA GACTTTGTTG AGGGTCTGCG TGTCTTTGAC 
AAGGAAGGCA ATGGCACAGT CATGGGTGCT GAACTCCGCC ATGTTCTAGC CACCCTGGGT 
GAAAAGATGA AAGAGGAAGA AGTGGAAGCC CTGATGGCAG GTCAAGAAGA CTCCAATGGC 
TGCATCAACT ACGAAGCTTT TGTCAAGCAC ATCATGTCTA TCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_524144.1
CDS	133..717
Translation	MAPKKDVKKPVAAAAAAPAPAPAPAPAPAPAKPKEEKIDLSAIKIEFSKEQQDEFKEAFLLFDRTGDSKITLSQVGDVLRALGTNPTNAEVRKVLGNPSNEELNAKKIEFEQFLPMMQAISNNKDQATYEDFVEGLRVFDKEGNGTVMGAELRHVLATLGEKMKEEEVEALMAGQEDSNGCINYEAFVKHIMSI

Target ORF information:

RefSeq Version	NM_079420.3
Organism	Homo sapiens(human)
Definition	Homo sapiens myosin light chain 1 (MYL1), transcript variant 1f, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_079420.3

ORF Insert Sequence:

ATGGCACCAA AGAAAGACGT GAAGAAACCT GTGGCTGCGG CTGCGGCTGC CCCAGCCCCG 
GCACCGGCAC CTGCACCTGC CCCTGCCCCA GCCAAACCCA AAGAAGAAAA AATTGACCTC 
TCTGCCATTA AGATCGAGTT CTCTAAGGAA CAGCAGGATG AATTCAAGGA GGCATTTCTC 
CTGTTTGACA GAACAGGTGA TTCCAAGATC ACCTTAAGCC AGGTCGGTGA TGTCCTTCGA 
GCTCTGGGCA CAAATCCCAC CAATGCAGAG GTCAGGAAAG TTCTGGGAAA CCCCAGCAAT 
GAAGAGCTGA ATGCCAAGAA AATTGAGTTT GAACAATTTC TGCCTATGAT GCAAGCCATT 
TCCAACAACA AGGACCAGGC CACCTATGAA GACTTTGTTG AGGGTCTGCG TGTCTTTGAC 
AAGGAAGGCA ATGGCACAGT CATGGGTGCT GAACTCCGCC ATGTTCTAGC CACCCTGGGT 
GAAAAGATGA AAGAGGAAGA AGTGGAAGCC CTGATGGCAG GTCAAGAAGA CTCCAATGGC 
TGCATCAACT ACGAAGCTTT TGTCAAGCAC ATCATGTCTA TCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Transient interaction between the N-terminal extension of the essential light chain-1 and motor domain of the myosin head during the ATPase cycle.
Biochemical and biophysical research communications495(1)163-167(2018 01)
Logvinova DS,Matyushenko AM,Nikolaeva OP,Levitsky DI

Myosin regulatory light chain phosphorylation is associated with leiomyosarcoma development.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie92810-818(2017 Aug)
Li HS,Lin Q,Wu J,Jiang ZH,Zhao JB,Pan J,He WQ,Zha JM

Distinct sequences and post-translational modifications in cardiac atrial and ventricular myosin light chains revealed by top-down mass spectrometry.
Journal of molecular and cellular cardiology10713-21(2017 Jun)
Gregorich ZR,Cai W,Lin Z,Chen AJ,Peng Y,Kohmoto T,Ge Y

Intron polymorphism in MYL1 gene is associated with individual cardiac trainability to endurance training in human myocardium.
The Journal of sports medicine and physical fitness57(1-2)144-153(2017 Jan-Feb)
Lin X,Wang D,Wen L,Zhou S,Hu Y,Zhang Y

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MYL1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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