MYH6 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	MYH6
Entrez Gene ID	4624
Full Name	myosin heavy chain 6
Synonyms	ASD3,CMD1EE,CMH14,MYHC,MYHCA,SSS3,alpha-MHC
General protein information	Preferred Names myosin heavy chain 6 Names myosin-6 myHC-alpha myosin heavy chain, cardiac muscle alpha isoform myosin, heavy polypeptide 6, cardiac muscle, alpha (cardiomyopathy, hypertrophic 1)
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 14 Map Location: 14q11.2
Summary	Cardiac muscle myosin is a hexamer consisting of two heavy chain subunits, two light chain subunits, and two regulatory subunits. This gene encodes the alpha heavy chain subunit of cardiac myosin. The gene is located approximately 4kb downstream of the gene encoding the beta heavy chain subunit of cardiac myosin. Mutations in this gene cause familial hypertrophic cardiomyopathy and atrial septal defect 3. [provided by RefSeq, Feb 2017].
Disorder MIM:	160710
Disorder Html:	Cardiomyopathy, hypertrophic, 14, 613251 (3); Atrial septal defect 3, 614089 (3); Cardiomyopathy, dilated, 1EE, 613252 (3); {Sick sinus syndrome 3}, 614090 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_002471.3	NP_002462.2	myosin-6

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	MYH6	XP_003952494.1
Canis lupus familiaris (dog)	MYH6	XP_003435121.2
Gallus gallus (chicken)	MYH15	NP_990097.1
Mus musculus (house mouse)	Myh6	NP_034986.1
Rattus norvegicus (Norway rat)	Myh6	NP_058935.2
Homo sapiens (human)	MYH6	NP_002462.2
	MYH6	XP_001102827.2
Bos taurus (cattle)	MYH6	XP_002690549.1
Danio rerio (zebrafish)	myh6	NP_942118.1
Xenopus tropicalis (tropical clawed frog)	myh6	XP_004910815.1

Gene Ontology
Bibliography

Related articles in PubMed

Contribution of rare inherited and de novo variants in 2,871 congenital heart disease probands.
Jin SC, Homsy J, Zaidi S, Lu Q, Morton S, DePalma SR, Zeng X, Qi H, Chang W, Sierant MC, Hung WC, Haider S, Zhang J, Knight J, Bjornson RD, Castaldi C, Tikhonoa IR, Bilguvar K, Mane SM, Sanders SJ, Mital S, Russell MW, Gaynor JW, Deanfield J, Giardini A, Porter GA Jr, Srivastava D, Lo CW, Shen Y, Watkins WS, Yandell M, Yost HJ, Tristani-Firouzi M, Newburger JW, Roberts AE, Kim R, Zhao H, Kaltman JR, Goldmuntz E, Chung WK, Seidman JG, Gelb BD, Seidman CE, Lifton RP, Brueckner M
Nature genetics49(11)1593-1601(2017 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Rare inherited and de novo variants in 2,871 congenital heart disease probands identified GDF1, MYH6, and FLT4 as causative genes.
Title: Contribution of rare inherited and de novo variants in 2,871 congenital heart disease probands.

the P830L and A1004S alphaMHC mutations alter myocyte contractility in completely different ways while at the same preserving peak intracellular calcium
Title: Altered myocyte contractility and calcium homeostasis in alpha-myosin heavy chain point mutations linked to familial dilated cardiomyopathy.

Data show that compound heterozygosity for recessive myosin heavy chain 6 (MYH6) mutations in patients with hypoplastic left heart and reduced systemic right ventricular ejection fraction.
Title: Recessive MYH6 Mutations in Hypoplastic Left Heart With Reduced Ejection Fraction.

human alpha- and beta-cardiac myosin, as well as the mutants, show opposite mechanical and enzymatic phenotypes with respect to each other.
Title: Ensemble force changes that result from human cardiac myosin mutations and a small-molecule effector.

The novel MYH6 mutation delE933 causes both structural damage of the sarcomere and functional impairments on atrial action propagation.
Title: Novel mutation in the ?-myosin heavy chain gene is associated with sick sinus syndrome.

The following MYH6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MYH6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu18394	NM_002471.3 Latest version!	Homo sapiens myosin heavy chain 6 (MYH6), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$923.30 $1319.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

MYH6 ( NM_002471.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_002462.2 Homo sapiens myosin heavy chain 6 (MYH6), mRNA.

Price & Availability↑

CloneID	OHu18394
Clone ID Related Accession (Same CDS sequence)	NM_002471.3
Accession Version	NM_002471.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 5820bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Homo sapiens(human)
Product	myosin-6
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BX501231.1, DA566231.1, BC132667.1, D00943.1 and M21664.1. This sequence is a reference standard in the RefSeqGene project. On Mar 2, 2010 this sequence version replaced NM_002471.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## CDS exon combination :: BC132667.1, D00943.1 [ECO:0000331] RNAseq introns :: single sample supports all introns SAMEA2155550, SAMEA2159607 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGACCGATG CCCAGATGGC TGACTTTGGG GCAGCGGCCC AGTACCTCCG CAAGTCAGAG 
AAGGAGCGTC TAGAGGCCCA GACCCGGCCC TTTGACATTC GCACTGAGTG CTTCGTGCCC 
GATGACAAGG AAGAGTTTGT CAAAGCCAAG ATTTTGTCCC GGGAGGGAGG CAAGGTCATT 
GCTGAAACCG AGAATGGGAA GACGGTGACT GTGAAGGAGG ACCAGGTGTT GCAGCAGAAC 
CCACCCAAGT TCGACAAGAT TGAGGACATG GCCATGCTGA CCTTCCTGCA CGAGCCCGCG 
GTGCTTTTCA ACCTCAAGGA GCGCTACGCG GCCTGGATGA TATATACCTA CTCGGGCCTC 
TTCTGTGTCA CTGTCAACCC CTACAAGTGG CTGCCGGTGT ACAATGCCGA GGTGGTGGCC 
GCCTACCGGG GCAAGAAGAG GAGTGAGGCC CCGCCCCACA TCTTCTCCAT CTCCGACAAC 
GCCTATCAGT ACATGCTGAC AGATCGGGAG AACCAGTCCA TCCTCATCAC GGGAGAATCC 
GGGGCGGGGA AGACTGTGAA CACCAAGCGT GTCATCCAGT ACTTTGCCAG CATTGCAGCC 
ATAGGTGACC GTGGCAAGAA GGACAATGCC AATGCGAACA AGGGCACCCT GGAGGACCAG 
ATCATCCAGG CCAACCCCGC TCTGGAGGCC TTCGGCAATG CCAAGACTGT CCGGAACGAC 
AACTCCTCCC GCTTTGGGAA ATTCATTAGG ATCCACTTTG GGGCCACTGG AAAGCTGGCT 
TCTGCAGACA TAGAGACCTA CCTGCTGGAG AAGTCCCGGG TGATCTTCCA GCTGAAAGCT 
GAGAGAAACT ACCACATCTT CTACCAGATT CTGTCCAACA AGAAGCCGGA GTTGCTGGAC 
ATGCTGCTGG TCACCAACAA TCCCTACGAC TACGCCTTCG TGTCTCAGGG AGAGGTGTCC 
GTGGCCTCCA TTGATGACTC CGAGGAGCTC ATGGCCACCG ATAGTGCCTT TGACGTGCTG 
GGCTTCACTT CAGAGGAGAA AGCTGGCGTC TACAAGCTGA CGGGAGCCAT CATGCACTAC 
GGGAACATGA AGTTCAAGCA GAAGCAGCGG GAGGAGCAGG CGGAGCCAGA CGGCACCGAA 
GATGCTGACA AGTCGGCCTA CCTCATGGGG CTGAACTCAG CTGACCTGCT CAAGGGGCTG 
TGCCACCCTC GGGTGAAAGT GGGCAACGAG TATGTCACCA AGGGGCAGAG CGTGCAGCAG 
GTGTACTACT CCATCGGGGC TCTGGCCAAG GCAGTGTATG AGAAGATGTT CAACTGGATG 
GTGACGCGCA TCAACGCCAC CCTGGAGACC AAGCAGCCAC GCCAGTACTT CATAGGAGTC 
CTGGACATCG CTGGCTTCGA GATCTTCGAC TTCAACAGCT TTGAGCAGCT CTGCATCAAC 
TTCACCAACG AGAAGCTGCA GCAGTTCTTC AACCACCACA TGTTCGTGCT GGAGCAGGAG 
GAGTACAAGA AGGAGGGCAT TGAGTGGACA TTCATTGACT TTGGCATGGA CCTGCAGGCC 
TGCATTGACC TCATCGAGAA GCCCATGGGC ATCATGTCCA TCCTGGAGGA GGAGTGCATG 
TTCCCCAAGG CCACTGACAT GACCTTCAAG GCCAAGCTGT ACGACAACCA CCTGGGCAAG 
TCCAACAATT TCCAGAAGCC ACGCAACATC AAGGGGAAGC AGGAAGCCCA CTTCTCCCTG 
ATCCACTACG CCGGCACTGT GGACTACAAC ATCCTGGGCT GGCTGGAAAA AAACAAGGAT 
CCTCTCAACG AGACTGTTGT GGCCCTGTAC CAGAAGTCCT CCCTCAAGCT CATGGCCACT 
CTCTTCTCCT CCTACGCAAC TGCCGATACT GGGGACAGTG GTAAAAGCAA AGGAGGCAAG 
AAAAAGGGCT CATCCTTCCA GACGGTGTCG GCTCTCCACC GGGAAAATCT CAACAAGCTA 
ATGACCAACC TGAGGACCAC CCATCCTCAC TTTGTGCGTT GCATCATCCC CAATGAGCGG 
AAGGCTCCAG GGGTGATGGA CAACCCCCTG GTCATGCACC AGCTGCGCTG CAATGGCGTG 
CTGGAGGGCA TCCGCATCTG CAGGAAGGGC TTCCCCAACC GCATCCTCTA CGGGGACTTC 
CGGCAGAGGT ATCGCATCCT GAACCCAGTG GCCATCCCTG AGGGACAGTT CATTGATAGC 
AGGAAGGGGA CAGAGAAGCT GCTCAGCTCT CTGGACATTG ATCACAACCA GTACAAGTTT 
GGCCACACCA AGGTGTTCTT CAAGGCAGGG CTGCTTGGGC TGCTGGAGGA GATGCGGGAT 
GAGAGGCTGA GCCGCATCAT CACGCGCATG CAGGCCCAAG CCCGGGGCCA GCTCATGCGC 
ATTGAGTTCA AGAAGATAGT GGAACGCAGG GATGCCCTGC TGGTAATCCA GTGGAACATT 
CGGGCCTTCA TGGGGGTCAA GAATTGGCCC TGGATGAAGC TCTACTTCAA GATCAAGCCG 
CTGCTGAAGA GCGCAGAGAC GGAGAAGGAG ATGGCCACCA TGAAGGAAGA GTTCGGGCGC 
ATCAAAGAGA CGCTGGAGAA GTCCGAGGCT CGCCGCAAGG AGCTGGAGGA GAAGATGGTG 
TCCCTGCTGC AGGAGAAGAA TGACCTGCAG CTCCAAGTGC AGGCGGAACA AGACAACCTC 
AATGATGCTG AGGAGCGCTG CGACCAGCTG ATCAAAAACA AGATTCAGCT GGAGGCCAAA 
GTAAAGGAGA TGAATGAGAG GCTGGAGGAT GAGGAGGAGA TGAACGCGGA GCTCACTGCC 
AAGAAGCGCA AGCTGGAAGA CGAGTGCTCA GAGCTCAAGA AGGACATTGA TGACCTGGAG 
CTGACACTGG CCAAGGTGGA GAAGGAGAAG CATGCAACAG AGAACAAGGT GAAGAACCTA 
ACAGAGGAGA TGGCTGGGCT GGATGAAATC ATCGCTAAGC TGACCAAGGA GAAGAAAGCT 
CTACAAGAGG CCCATCAGCA GGCCCTGGAT GACCTTCAGG TTGAGGAAGA CAAGGTCAAC 
AGCCTGTCCA AGTCTAAGGT CAAGCTGGAG CAGCAGGTGG ATGATCTGGA GGGATCCCTA 
GAGCAAGAGA AGAAGGTGCG CATGGACCTG GAGCGAGCAA AGCGGAAACT GGAGGGCGAC 
CTGAAGCTGA CCCAGGAGAG CATCATGGAC CTGGAAAATG ATAAACTGCA GCTGGAAGAA 
AAGCTTAAGA AGAAGGAGTT TGACATTAAT CAGCAGAACA GTAAGATTGA GGATGAGCAG 
GTGCTGGCCC TTCAACTACA GAAGAAACTG AAGGAAAACC AGGCACGCAT CGAGGAGCTG 
GAGGAGGAGC TGGAGGCCGA GCGCACCGCC AGGGCTAAGG TGGAGAAGCT GCGCTCAGAC 
CTGTCTCGGG AGCTGGAGGA GATCAGCGAG CGGCTGGAAG AGGCCGGCGG GGCCACGTCC 
GTGCAGATCG AGATGAACAA GAAGCGCGAG GCCGAGTTCC AGAAGATGCG GCGGGACCTG 
GAGGAGGCCA CGCTGCAGCA CGAGGCCACT GCCGCGGCCC TGCGCAAGAA GCACGCCGAC 
AGCGTGGCCG AGCTGGGCGA GCAGATCGAC AACCTGCAGC GGGTGAAGCA GAAGCTGGAG 
AAGGAGAAGA GCGAGTTCAA GCTGGAGCTG GATGACGTCA CCTCCAACAT GGAGCAGATC 
ATCAAGGCCA AGGCAAACCT GGAGAAAGTG TCTCGGACGC TGGAGGACCA GGCCAATGAG 
TACCGCGTGA AGCTAGAAGA GGCCCAACGC TCCCTCAATG ATTTCACCAC CCAGCGAGCC 
AAGCTGCAGA CCGAGAATGG AGAGTTGGCC CGGCAGCTAG AGGAAAAGGA GGCGCTAATC 
TCGCAGCTGA CCCGGGGGAA GCTCTCTTAT ACCCAGCAAA TGGAGGACCT CAAAAGGCAG 
CTGGAGGAGG AGGGCAAGGC GAAGAACGCC CTGGCCCATG CACTGCAGTC GGCCCGGCAT 
GACTGCGACC TGCTGCGGGA GCAGTACGAG GAGGAGACAG AGGCCAAGGC CGAGCTGCAG 
CGCGTCCTGT CCAAGGCCAA CTCGGAGGTG GCCCAGTGGA GGACCAAGTA TGAGACGGAC 
GCCATTCAGC GGACTGAGGA GCTCGAAGAG GCCAAAAAGA AGCTGGCCCA GCGGCTGCAG 
GATGCCGAGG AGGCCGTGGA GGCTGTTAAT GCCAAGTGCT CCTCACTGGA GAAGACCAAG 
CACCGGCTAC AGAATGAGAT AGAGGACTTG ATGGTGGACG TAGAGCGCTC CAATGCTGCT 
GCTGCAGCCC TGGACAAGAA GCAGAGAAAC TTTGACAAGA TCCTGGCCGA GTGGAAGCAG 
AAGTATGAGG AGTCGCAGTC TGAGCTGGAG TCCTCACAGA AGGAGGCTCG CTCCCTCAGC 
ACAGAGCTCT TCAAGCTCAA GAACGCCTAC GAGGAGTCCC TGGAGCACCT AGAGACCTTC 
AAGCGGGAGA ACAAGAACCT TCAGGAGGAA ATCTCGGACC TTACTGAGCA GCTAGGAGAA 
GGAGGAAAGA ATGTGCATGA GCTGGAGAAG GTCCGCAAAC AGCTGGAGGT GGAGAAGCTG 
GAGCTGCAGT CAGCCCTGGA GGAGGCAGAG GCCTCCCTGG AGCACGAGGA GGGCAAGATC 
CTCCGGGCCC AGCTAGAGTT CAACCAGATC AAGGCAGAGA TCGAGCGGAA GCTGGCAGAG 
AAGGACGAGG AGATGGAACA GGCCAAGCGC AACCACCAGC GGGTGGTGGA CTCGCTGCAG 
ACCTCCCTGG ATGCAGAGAC ACGCAGCCGC AACGAGGTCC TGAGGGTGAA GAAGAAGATG 
GAAGGAGACC TCAATGAGAT GGAGATCCAG CTCAGCCACG CCAACCGCAT GGCTGCCGAG 
GCCCAGAAGC AAGTCAAGAG CCTCCAGAGC TTGCTGAAGG ACACCCAGAT CCAGCTGGAC 
GATGCGGTCC GTGCCAACGA CGACCTGAAG GAGAACATCG CCATCGTGGA GCGGCGCAAC 
AACCTGCTGC AGGCTGAGCT GGAGGAGCTG CGTGCCGTGG TGGAGCAGAC AGAGCGGTCC 
CGGAAGCTGG CGGAGCAGGA GCTGATTGAG ACCAGCGAGC GGGTGCAGCT GCTGCATTCC 
CAGAACACCA GCCTCATCAA CCAGAAGAAG AAGATGGAGT CGGATCTGAC CCAGCTCCAG 
TCGGAAGTGG AGGAGGCAGT GCAGGAGTGC AGAAACGCCG AGGAGAAGGC CAAGAAGGCC 
ATCACGGATG CCGCCATGAT GGCAGAGGAG CTGAAGAAGG AGCAGGACAC CAGCGCCCAC 
CTGGAGCGCA TGAAGAAGAA CATGGAGCAG ACCATTAAGG ACCTGCAGCA CCGGCTGGAC 
GAGGCCGAGC AGATCGCCCT CAAGGGAGGC AAGAAGCAGC TGCAGAAGCT GGAAGCGCGG 
GTGCGGGAGC TGGAGGGTGA GCTGGAGGCC GAGCAGAAGC GCAACGCAGA GTCGGTGAAG 
GGCATGAGGA AGAGCGAGCG GCGCATCAAG GAGCTCACCT ACCAGACAGA GGAAGACAAA 
AAGAACCTGC TGCGGCTACA GGACCTGGTG GACAAGCTGC AACTGAAGGT CAAGGCCTAC 
AAGCGCCAGG CCGAGGAGGC GGAGGAGCAA GCCAACACCA ACCTGTCCAA GTTCCGCAAG 
GTGCAGCATG AGCTGGATGA GGCAGAGGAG CGGGCGGACA TCGCTGAGTC CCAGGTCAAC 
AAGCTTCGAG CCAAGAGCCG TGACATTGGT GCCAAGCAAA AAATGCACGA TGAGGAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002462.2
CDS	72..5891
Translation	MTDAQMADFGAAAQYLRKSEKERLEAQTRPFDIRTECFVPDDKEEFVKAKILSREGGKVIAETENGKTVTVKEDQVLQQNPPKFDKIEDMAMLTFLHEPAVLFNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNAEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITGESGAGKTVNTKRVIQYFASIAAIGDRGKKDNANANKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKLASADIETYLLEKSRVIFQLKAERNYHIFYQILSNKKPELLDMLLVTNNPYDYAFVSQGEVSVASIDDSEELMATDSAFDVLGFTSEEKAGVYKLTGAIMHYGNMKFKQKQREEQAEPDGTEDADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQSVQQVYYSIGALAKAVYEKMFNWMVTRINATLETKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGMDLQACIDLIEKPMGIMSILEEECMFPKATDMTFKAKLYDNHLGKSNNFQKPRNIKGKQEAHFSLIHYAGTVDYNILGWLEKNKDPLNETVVALYQKSSLKLMATLFSSYATADTGDSGKSKGGKKKGSSFQTVSALHRENLNKLMTNLRTTHPHFVRCIIPNERKAPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNPVAIPEGQFIDSRKGTEKLLSSLDIDHNQYKFGHTKVFFKAGLLGLLEEMRDERLSRIITRMQAQARGQLMRIEFKKIVERRDALLVIQWNIRAFMGVKNWPWMKLYFKIKPLLKSAETEKEMATMKEEFGRIKETLEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLNDAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQVEEDKVNSLSKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKLQLEEKLKKKEFDINQQNSKIEDEQVLALQLQKKLKENQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQTENGELARQLEEKEALISQLTRGKLSYTQQMEDLKRQLEEEGKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGEGGKNVHELEKVRKQLEVEKLELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHQRVVDSLQTSLDAETRSRNEVLRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMESDLTQLQSEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELEGELEAEQKRNAESVKGMRKSERRIKELTYQTEEDKKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADIAESQVNKLRAKSRDIGAKQKMHDEE

Target ORF information:

RefSeq Version	NM_002471.3
Organism	Homo sapiens(human)
Definition	Homo sapiens myosin heavy chain 6 (MYH6), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002471.3

ORF Insert Sequence:

ATGACCGATG CCCAGATGGC TGACTTTGGG GCAGCGGCCC AGTACCTCCG CAAGTCAGAG 
AAGGAGCGTC TAGAGGCCCA GACCCGGCCC TTTGACATTC GCACTGAGTG CTTCGTGCCC 
GATGACAAGG AAGAGTTTGT CAAAGCCAAG ATTTTGTCCC GGGAGGGAGG CAAGGTCATT 
GCTGAAACCG AGAATGGGAA GACGGTGACT GTGAAGGAGG ACCAGGTGTT GCAGCAGAAC 
CCACCCAAGT TCGACAAGAT TGAGGACATG GCCATGCTGA CCTTCCTGCA CGAGCCCGCG 
GTGCTTTTCA ACCTCAAGGA GCGCTACGCG GCCTGGATGA TATATACCTA CTCGGGCCTC 
TTCTGTGTCA CTGTCAACCC CTACAAGTGG CTGCCGGTGT ACAATGCCGA GGTGGTGGCC 
GCCTACCGGG GCAAGAAGAG GAGTGAGGCC CCGCCCCACA TCTTCTCCAT CTCCGACAAC 
GCCTATCAGT ACATGCTGAC AGATCGGGAG AACCAGTCCA TCCTCATCAC GGGAGAATCC 
GGGGCGGGGA AGACTGTGAA CACCAAGCGT GTCATCCAGT ACTTTGCCAG CATTGCAGCC 
ATAGGTGACC GTGGCAAGAA GGACAATGCC AATGCGAACA AGGGCACCCT GGAGGACCAG 
ATCATCCAGG CCAACCCCGC TCTGGAGGCC TTCGGCAATG CCAAGACTGT CCGGAACGAC 
AACTCCTCCC GCTTTGGGAA ATTCATTAGG ATCCACTTTG GGGCCACTGG AAAGCTGGCT 
TCTGCAGACA TAGAGACCTA CCTGCTGGAG AAGTCCCGGG TGATCTTCCA GCTGAAAGCT 
GAGAGAAACT ACCACATCTT CTACCAGATT CTGTCCAACA AGAAGCCGGA GTTGCTGGAC 
ATGCTGCTGG TCACCAACAA TCCCTACGAC TACGCCTTCG TGTCTCAGGG AGAGGTGTCC 
GTGGCCTCCA TTGATGACTC CGAGGAGCTC ATGGCCACCG ATAGTGCCTT TGACGTGCTG 
GGCTTCACTT CAGAGGAGAA AGCTGGCGTC TACAAGCTGA CGGGAGCCAT CATGCACTAC 
GGGAACATGA AGTTCAAGCA GAAGCAGCGG GAGGAGCAGG CGGAGCCAGA CGGCACCGAA 
GATGCTGACA AGTCGGCCTA CCTCATGGGG CTGAACTCAG CTGACCTGCT CAAGGGGCTG 
TGCCACCCTC GGGTGAAAGT GGGCAACGAG TATGTCACCA AGGGGCAGAG CGTGCAGCAG 
GTGTACTACT CCATCGGGGC TCTGGCCAAG GCAGTGTATG AGAAGATGTT CAACTGGATG 
GTGACGCGCA TCAACGCCAC CCTGGAGACC AAGCAGCCAC GCCAGTACTT CATAGGAGTC 
CTGGACATCG CTGGCTTCGA GATCTTCGAC TTCAACAGCT TTGAGCAGCT CTGCATCAAC 
TTCACCAACG AGAAGCTGCA GCAGTTCTTC AACCACCACA TGTTCGTGCT GGAGCAGGAG 
GAGTACAAGA AGGAGGGCAT TGAGTGGACA TTCATTGACT TTGGCATGGA CCTGCAGGCC 
TGCATTGACC TCATCGAGAA GCCCATGGGC ATCATGTCCA TCCTGGAGGA GGAGTGCATG 
TTCCCCAAGG CCACTGACAT GACCTTCAAG GCCAAGCTGT ACGACAACCA CCTGGGCAAG 
TCCAACAATT TCCAGAAGCC ACGCAACATC AAGGGGAAGC AGGAAGCCCA CTTCTCCCTG 
ATCCACTACG CCGGCACTGT GGACTACAAC ATCCTGGGCT GGCTGGAAAA AAACAAGGAT 
CCTCTCAACG AGACTGTTGT GGCCCTGTAC CAGAAGTCCT CCCTCAAGCT CATGGCCACT 
CTCTTCTCCT CCTACGCAAC TGCCGATACT GGGGACAGTG GTAAAAGCAA AGGAGGCAAG 
AAAAAGGGCT CATCCTTCCA GACGGTGTCG GCTCTCCACC GGGAAAATCT CAACAAGCTA 
ATGACCAACC TGAGGACCAC CCATCCTCAC TTTGTGCGTT GCATCATCCC CAATGAGCGG 
AAGGCTCCAG GGGTGATGGA CAACCCCCTG GTCATGCACC AGCTGCGCTG CAATGGCGTG 
CTGGAGGGCA TCCGCATCTG CAGGAAGGGC TTCCCCAACC GCATCCTCTA CGGGGACTTC 
CGGCAGAGGT ATCGCATCCT GAACCCAGTG GCCATCCCTG AGGGACAGTT CATTGATAGC 
AGGAAGGGGA CAGAGAAGCT GCTCAGCTCT CTGGACATTG ATCACAACCA GTACAAGTTT 
GGCCACACCA AGGTGTTCTT CAAGGCAGGG CTGCTTGGGC TGCTGGAGGA GATGCGGGAT 
GAGAGGCTGA GCCGCATCAT CACGCGCATG CAGGCCCAAG CCCGGGGCCA GCTCATGCGC 
ATTGAGTTCA AGAAGATAGT GGAACGCAGG GATGCCCTGC TGGTAATCCA GTGGAACATT 
CGGGCCTTCA TGGGGGTCAA GAATTGGCCC TGGATGAAGC TCTACTTCAA GATCAAGCCG 
CTGCTGAAGA GCGCAGAGAC GGAGAAGGAG ATGGCCACCA TGAAGGAAGA GTTCGGGCGC 
ATCAAAGAGA CGCTGGAGAA GTCCGAGGCT CGCCGCAAGG AGCTGGAGGA GAAGATGGTG 
TCCCTGCTGC AGGAGAAGAA TGACCTGCAG CTCCAAGTGC AGGCGGAACA AGACAACCTC 
AATGATGCTG AGGAGCGCTG CGACCAGCTG ATCAAAAACA AGATTCAGCT GGAGGCCAAA 
GTAAAGGAGA TGAATGAGAG GCTGGAGGAT GAGGAGGAGA TGAACGCGGA GCTCACTGCC 
AAGAAGCGCA AGCTGGAAGA CGAGTGCTCA GAGCTCAAGA AGGACATTGA TGACCTGGAG 
CTGACACTGG CCAAGGTGGA GAAGGAGAAG CATGCAACAG AGAACAAGGT GAAGAACCTA 
ACAGAGGAGA TGGCTGGGCT GGATGAAATC ATCGCTAAGC TGACCAAGGA GAAGAAAGCT 
CTACAAGAGG CCCATCAGCA GGCCCTGGAT GACCTTCAGG TTGAGGAAGA CAAGGTCAAC 
AGCCTGTCCA AGTCTAAGGT CAAGCTGGAG CAGCAGGTGG ATGATCTGGA GGGATCCCTA 
GAGCAAGAGA AGAAGGTGCG CATGGACCTG GAGCGAGCAA AGCGGAAACT GGAGGGCGAC 
CTGAAGCTGA CCCAGGAGAG CATCATGGAC CTGGAAAATG ATAAACTGCA GCTGGAAGAA 
AAGCTTAAGA AGAAGGAGTT TGACATTAAT CAGCAGAACA GTAAGATTGA GGATGAGCAG 
GTGCTGGCCC TTCAACTACA GAAGAAACTG AAGGAAAACC AGGCACGCAT CGAGGAGCTG 
GAGGAGGAGC TGGAGGCCGA GCGCACCGCC AGGGCTAAGG TGGAGAAGCT GCGCTCAGAC 
CTGTCTCGGG AGCTGGAGGA GATCAGCGAG CGGCTGGAAG AGGCCGGCGG GGCCACGTCC 
GTGCAGATCG AGATGAACAA GAAGCGCGAG GCCGAGTTCC AGAAGATGCG GCGGGACCTG 
GAGGAGGCCA CGCTGCAGCA CGAGGCCACT GCCGCGGCCC TGCGCAAGAA GCACGCCGAC 
AGCGTGGCCG AGCTGGGCGA GCAGATCGAC AACCTGCAGC GGGTGAAGCA GAAGCTGGAG 
AAGGAGAAGA GCGAGTTCAA GCTGGAGCTG GATGACGTCA CCTCCAACAT GGAGCAGATC 
ATCAAGGCCA AGGCAAACCT GGAGAAAGTG TCTCGGACGC TGGAGGACCA GGCCAATGAG 
TACCGCGTGA AGCTAGAAGA GGCCCAACGC TCCCTCAATG ATTTCACCAC CCAGCGAGCC 
AAGCTGCAGA CCGAGAATGG AGAGTTGGCC CGGCAGCTAG AGGAAAAGGA GGCGCTAATC 
TCGCAGCTGA CCCGGGGGAA GCTCTCTTAT ACCCAGCAAA TGGAGGACCT CAAAAGGCAG 
CTGGAGGAGG AGGGCAAGGC GAAGAACGCC CTGGCCCATG CACTGCAGTC GGCCCGGCAT 
GACTGCGACC TGCTGCGGGA GCAGTACGAG GAGGAGACAG AGGCCAAGGC CGAGCTGCAG 
CGCGTCCTGT CCAAGGCCAA CTCGGAGGTG GCCCAGTGGA GGACCAAGTA TGAGACGGAC 
GCCATTCAGC GGACTGAGGA GCTCGAAGAG GCCAAAAAGA AGCTGGCCCA GCGGCTGCAG 
GATGCCGAGG AGGCCGTGGA GGCTGTTAAT GCCAAGTGCT CCTCACTGGA GAAGACCAAG 
CACCGGCTAC AGAATGAGAT AGAGGACTTG ATGGTGGACG TAGAGCGCTC CAATGCTGCT 
GCTGCAGCCC TGGACAAGAA GCAGAGAAAC TTTGACAAGA TCCTGGCCGA GTGGAAGCAG 
AAGTATGAGG AGTCGCAGTC TGAGCTGGAG TCCTCACAGA AGGAGGCTCG CTCCCTCAGC 
ACAGAGCTCT TCAAGCTCAA GAACGCCTAC GAGGAGTCCC TGGAGCACCT AGAGACCTTC 
AAGCGGGAGA ACAAGAACCT TCAGGAGGAA ATCTCGGACC TTACTGAGCA GCTAGGAGAA 
GGAGGAAAGA ATGTGCATGA GCTGGAGAAG GTCCGCAAAC AGCTGGAGGT GGAGAAGCTG 
GAGCTGCAGT CAGCCCTGGA GGAGGCAGAG GCCTCCCTGG AGCACGAGGA GGGCAAGATC 
CTCCGGGCCC AGCTAGAGTT CAACCAGATC AAGGCAGAGA TCGAGCGGAA GCTGGCAGAG 
AAGGACGAGG AGATGGAACA GGCCAAGCGC AACCACCAGC GGGTGGTGGA CTCGCTGCAG 
ACCTCCCTGG ATGCAGAGAC ACGCAGCCGC AACGAGGTCC TGAGGGTGAA GAAGAAGATG 
GAAGGAGACC TCAATGAGAT GGAGATCCAG CTCAGCCACG CCAACCGCAT GGCTGCCGAG 
GCCCAGAAGC AAGTCAAGAG CCTCCAGAGC TTGCTGAAGG ACACCCAGAT CCAGCTGGAC 
GATGCGGTCC GTGCCAACGA CGACCTGAAG GAGAACATCG CCATCGTGGA GCGGCGCAAC 
AACCTGCTGC AGGCTGAGCT GGAGGAGCTG CGTGCCGTGG TGGAGCAGAC AGAGCGGTCC 
CGGAAGCTGG CGGAGCAGGA GCTGATTGAG ACCAGCGAGC GGGTGCAGCT GCTGCATTCC 
CAGAACACCA GCCTCATCAA CCAGAAGAAG AAGATGGAGT CGGATCTGAC CCAGCTCCAG 
TCGGAAGTGG AGGAGGCAGT GCAGGAGTGC AGAAACGCCG AGGAGAAGGC CAAGAAGGCC 
ATCACGGATG CCGCCATGAT GGCAGAGGAG CTGAAGAAGG AGCAGGACAC CAGCGCCCAC 
CTGGAGCGCA TGAAGAAGAA CATGGAGCAG ACCATTAAGG ACCTGCAGCA CCGGCTGGAC 
GAGGCCGAGC AGATCGCCCT CAAGGGAGGC AAGAAGCAGC TGCAGAAGCT GGAAGCGCGG 
GTGCGGGAGC TGGAGGGTGA GCTGGAGGCC GAGCAGAAGC GCAACGCAGA GTCGGTGAAG 
GGCATGAGGA AGAGCGAGCG GCGCATCAAG GAGCTCACCT ACCAGACAGA GGAAGACAAA 
AAGAACCTGC TGCGGCTACA GGACCTGGTG GACAAGCTGC AACTGAAGGT CAAGGCCTAC 
AAGCGCCAGG CCGAGGAGGC GGAGGAGCAA GCCAACACCA ACCTGTCCAA GTTCCGCAAG 
GTGCAGCATG AGCTGGATGA GGCAGAGGAG CGGGCGGACA TCGCTGAGTC CCAGGTCAAC 
AAGCTTCGAG CCAAGAGCCG TGACATTGGT GCCAAGCAAA AAATGCACGA TGAGGAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Contribution of rare inherited and de novo variants in 2,871 congenital heart disease probands.
Nature genetics49(11)1593-1601(2017 Nov)
Jin SC,Homsy J,Zaidi S,Lu Q,Morton S,DePalma SR,Zeng X,Qi H,Chang W,Sierant MC,Hung WC,Haider S,Zhang J,Knight J,Bjornson RD,Castaldi C,Tikhonoa IR,Bilguvar K,Mane SM,Sanders SJ,Mital S,Russell MW,Gaynor JW,Deanfield J,Giardini A,Porter GA Jr,Srivastava D,Lo CW,Shen Y,Watkins WS,Yandell M,Yost HJ,Tristani-Firouzi M,Newburger JW,Roberts AE,Kim R,Zhao H,Kaltman JR,Goldmuntz E,Chung WK,Seidman JG,Gelb BD,Seidman CE,Lifton RP,Brueckner M

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MYH6 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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