GADD45B cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	GADD45B
Entrez Gene ID	4616
Full Name	growth arrest and DNA damage inducible beta
Synonyms	GADD45BETA,MYD118
General protein information	Preferred Names growth arrest and DNA damage inducible beta Names growth arrest and DNA damage-inducible protein GADD45 beta myeloid differentiation primary response protein MyD118 negative growth regulatory protein MyD118
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 19 Map Location: 19p13.3
Summary	This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The genes in this group respond to environmental stresses by mediating activation of the p38/JNK pathway. This activation is mediated via their proteins binding and activating MTK1/MEKK4 kinase, which is an upstream activator of both p38 and JNK MAPKs. The function of these genes or their protein products is involved in the regulation of growth and apoptosis. These genes are regulated by different mechanisms, but they are often coordinately expressed and can function cooperatively in inhibiting cell growth. [provided by RefSeq, Jul 2008].
Disorder MIM:	604948

mRNA and Protein(s)

mRNA	Protein	Name
NM_015675.3	NP_056490.2	growth arrest and DNA damage-inducible protein GADD45 beta
XM_017026822.1	XP_016882311.1	growth arrest and DNA damage-inducible protein GADD45 beta isoform X1
NM_015675.4	NP_056490.2	growth arrest and DNA damage-inducible protein GADD45 beta

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	GADD45B	XP_001151983.1
Canis lupus familiaris (dog)	GADD45B	XP_542187.1
Gallus gallus (chicken)	LOC100859853	XP_003643868.2
Xenopus tropicalis (tropical clawed frog)	gadd45b	XP_002941163.2
	GADD45B	XP_001098598.1
Bos taurus (cattle)	GADD45B	NP_001035694.1
Mus musculus (house mouse)	Gadd45b	NP_032681.1
Danio rerio (zebrafish)	gadd45ba	NP_998196.1
Danio rerio (zebrafish)	gadd45bb	NP_001012386.1
Rattus norvegicus (Norway rat)	Gadd45b	NP_001008322.1
Homo sapiens (human)	GADD45B	NP_056490.2

Gene Ontology
Bibliography

Related articles in PubMed

Matrine inhibits the progression of prostate cancer by promoting expression of GADD45B.
Huang H, Wang Q, Du T, Lin C, Lai Y, Zhu D, Wu W, Ma X, Bai S, Li Z, Liu L, Li Q
The Prostate(2018 Jan)

GADD45? loss ablates innate immunosuppression in cancer.
Verzella D, Bennett J, Fischietti M, Thotakura AK, Recordati C, Pasqualini F, Capece D, Vecchiotti D, D'Andrea D, Di Francesco B, De Maglie M, Begalli F, Tornatore L, Papa S, Lawrence T, Forbes S, Sica A, Alesse E, Zazzeroni F, Franzoso G
Cancer research(2017 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These findings demonstrate that 19p13.3-GADD45B rs7354 variant and interaction between 19p13.3-GADD45B rs3783501 and 19q13.3-CD3EAP rs967591 may play a role in association with smoke-exposed lung cancer among Chinese.
Title: 19p13.3-GADD45B common variants and 19q13.3-PPP1R13L and 19q13.3-CD3EAP in lung cancer risk among Chinese.

Gadd45beta could be a suitable biomarker of cardiomyocytes apoptosis in newborns experiencing hypoxia in the first day of life, as its highest tissue immunoexpression around at the first six hours after birth.
Title: Immunoexpression of GADD45? in the myocardium of newborns experiencing perinatal hypoxia.

We used a new approach to search for human genes repressed by small nucleic acids (microRNAs) expressed by a gammaherpesvirus (KSHV), which identified a gene called GADD45B as a target of microRNAs. Repression of GADD45B, which is expressed in response to DNA damage, benefited survival of infected cells in response to a DNA damage response. This information could be used to design new treatments for herpesvirus infections
Title: Kaposi's Sarcoma-Associated Herpesvirus MicroRNAs Target GADD45B To Protect Infected Cells from Cell Cycle Arrest and Apoptosis.

Nrf2-Gadd45b signaling axis exhibited a protective role in antimony trioxide-induced cell apoptosis.
Title: The protective role of Nrf2-Gadd45b against antimony-induced oxidative stress and apoptosis in HEK293 cells.

present study provides evidence that variations in GADD45B rs2024144T, MAPK14 rs3804451A and GADD45A rs581000C may predict platinum-based chemotherapy toxicity outcomes in patients with advanced non-small cell lung cancer
Title: Genetic variants of GADD45A, GADD45B and MAPK14 predict platinum-based chemotherapy-induced toxicities in Chinese patients with non-small cell lung cancer.

The following GADD45B gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the GADD45B cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu09336	NM_015675.4 Latest version!	Homo sapiens growth arrest and DNA damage inducible beta (GADD45B), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu88475	XM_017026822.1 Latest version!	Homo sapiens growth arrest and DNA damage inducible beta (GADD45B), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
View Old Accession Versions >>
OHu09336	NM_015675.3	Homo sapiens growth arrest and DNA damage inducible beta (GADD45B), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

GADD45B ( NM_015675.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_056490.2 Homo sapiens growth arrest and DNA damage inducible beta (GADD45B), mRNA.

Price & Availability↑

CloneID	OHu09336
Clone ID Related Accession (Same CDS sequence)	NM_015675.3 , NM_015675.4
Accession Version	NM_015675.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 483bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-11-12
Organism	Homo sapiens(human)
Product	growth arrest and DNA damage-inducible protein GADD45 beta
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP225713.1, AK293087.1 and BM670459.1. On Jun 29, 2010 this sequence version replaced NM_015675.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF087853.1, SRR1163655.695235.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGACGCTGG AAGAGCTCGT GGCGTGCGAC AACGCGGCGC AGAAGATGCA GACGGTGACC 
GCCGCGGTGG AGGAGCTTTT GGTGGCCGCT CAGCGCCAGG ATCGCCTCAC AGTGGGGGTG 
TACGAGTCGG CCAAGTTGAT GAATGTGGAC CCAGACAGCG TGGTCCTCTG CCTCTTGGCC 
ATTGACGAGG AGGAGGAGGA TGACATCGCC CTGCAAATCC ACTTCACGCT CATCCAGTCC 
TTCTGCTGTG ACAACGACAT CAACATCGTG CGGGTGTCGG GCATGCAGCG CCTGGCGCAG 
CTCCTGGGAG AGCCGGCCGA GACCCAGGGC ACCACCGAGG CCCGAGACCT GCATTGTCTC 
CTGGTCACGA ACCCTCACAC GGACGCCTGG AAGAGCCACG GCTTGGTGGA GGTGGCCAGC 
TACTGCGAAG AAAGCCGGGG CAACAACCAG TGGGTCCCCT ACATCTCTCT TCAGGAACGC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_056490.2
CDS	235..717
Translation	MTLEELVACDNAAQKMQTVTAAVEELLVAAQRQDRLTVGVYESAKLMNVDPDSVVLCLLAIDEEEEDDIALQIHFTLIQSFCCDNDINIVRVSGMQRLAQLLGEPAETQGTTEARDLHCLLVTNPHTDAWKSHGLVEVASYCEESRGNNQWVPYISLQER

Target ORF information:

RefSeq Version	NM_015675.3
Organism	Homo sapiens(human)
Definition	Homo sapiens growth arrest and DNA damage inducible beta (GADD45B), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_015675.3

ORF Insert Sequence:

ATGACGCTGG AAGAGCTCGT GGCGTGCGAC AACGCGGCGC AGAAGATGCA GACGGTGACC 
GCCGCGGTGG AGGAGCTTTT GGTGGCCGCT CAGCGCCAGG ATCGCCTCAC AGTGGGGGTG 
TACGAGTCGG CCAAGTTGAT GAATGTGGAC CCAGACAGCG TGGTCCTCTG CCTCTTGGCC 
ATTGACGAGG AGGAGGAGGA TGACATCGCC CTGCAAATCC ACTTCACGCT CATCCAGTCC 
TTCTGCTGTG ACAACGACAT CAACATCGTG CGGGTGTCGG GCATGCAGCG CCTGGCGCAG 
CTCCTGGGAG AGCCGGCCGA GACCCAGGGC ACCACCGAGG CCCGAGACCT GCATTGTCTC 
CTGGTCACGA ACCCTCACAC GGACGCCTGG AAGAGCCACG GCTTGGTGGA GGTGGCCAGC 
TACTGCGAAG AAAGCCGGGG CAACAACCAG TGGGTCCCCT ACATCTCTCT TCAGGAACGC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GADD45B ( NM_015675.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_056490.2 Homo sapiens growth arrest and DNA damage inducible beta (GADD45B), mRNA.

Price & Availability↑

CloneID	OHu09336
Clone ID Related Accession (Same CDS sequence)	NM_015675.3 , NM_015675.4
Accession Version	NM_015675.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 483bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-07
Organism	Homo sapiens(human)
Product	growth arrest and DNA damage-inducible protein GADD45 beta
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK293087.1 and BM670459.1. On Nov 24, 2018 this sequence version replaced NM_015675.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.236157.1, SRR3476690.397772.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000215631.9/ ENSP00000215631.3 RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGACGCTGG AAGAGCTCGT GGCGTGCGAC AACGCGGCGC AGAAGATGCA GACGGTGACC 
GCCGCGGTGG AGGAGCTTTT GGTGGCCGCT CAGCGCCAGG ATCGCCTCAC AGTGGGGGTG 
TACGAGTCGG CCAAGTTGAT GAATGTGGAC CCAGACAGCG TGGTCCTCTG CCTCTTGGCC 
ATTGACGAGG AGGAGGAGGA TGACATCGCC CTGCAAATCC ACTTCACGCT CATCCAGTCC 
TTCTGCTGTG ACAACGACAT CAACATCGTG CGGGTGTCGG GCATGCAGCG CCTGGCGCAG 
CTCCTGGGAG AGCCGGCCGA GACCCAGGGC ACCACCGAGG CCCGAGACCT GCATTGTCTC 
CTGGTCACGA ACCCTCACAC GGACGCCTGG AAGAGCCACG GCTTGGTGGA GGTGGCCAGC 
TACTGCGAAG AAAGCCGGGG CAACAACCAG TGGGTCCCCT ACATCTCTCT TCAGGAACGC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_056490.2
CDS	233..715
Translation	MTLEELVACDNAAQKMQTVTAAVEELLVAAQRQDRLTVGVYESAKLMNVDPDSVVLCLLAIDEEEEDDIALQIHFTLIQSFCCDNDINIVRVSGMQRLAQLLGEPAETQGTTEARDLHCLLVTNPHTDAWKSHGLVEVASYCEESRGNNQWVPYISLQER

Target ORF information:

RefSeq Version	NM_015675.4
Organism	Homo sapiens(human)
Definition	Homo sapiens growth arrest and DNA damage inducible beta (GADD45B), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_015675.4

ORF Insert Sequence:

ATGACGCTGG AAGAGCTCGT GGCGTGCGAC AACGCGGCGC AGAAGATGCA GACGGTGACC 
GCCGCGGTGG AGGAGCTTTT GGTGGCCGCT CAGCGCCAGG ATCGCCTCAC AGTGGGGGTG 
TACGAGTCGG CCAAGTTGAT GAATGTGGAC CCAGACAGCG TGGTCCTCTG CCTCTTGGCC 
ATTGACGAGG AGGAGGAGGA TGACATCGCC CTGCAAATCC ACTTCACGCT CATCCAGTCC 
TTCTGCTGTG ACAACGACAT CAACATCGTG CGGGTGTCGG GCATGCAGCG CCTGGCGCAG 
CTCCTGGGAG AGCCGGCCGA GACCCAGGGC ACCACCGAGG CCCGAGACCT GCATTGTCTC 
CTGGTCACGA ACCCTCACAC GGACGCCTGG AAGAGCCACG GCTTGGTGGA GGTGGCCAGC 
TACTGCGAAG AAAGCCGGGG CAACAACCAG TGGGTCCCCT ACATCTCTCT TCAGGAACGC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GADD45B ( XM_017026822.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016882311.1 Homo sapiens growth arrest and DNA damage inducible beta (GADD45B), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu88475
Clone ID Related Accession (Same CDS sequence)	XM_017026822.1
Accession Version	XM_017026822.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 531bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	growth arrest and DNA damage-inducible protein GADD45 beta isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000019.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGACGCTGG AAGAGCTCGT GGCGTGCGAC AACGCGGCGC AGAAGATGCA GACGGTGACC 
GCCGCGGTGG AGGAGCTTTT GGTGGCCGCT CAGCGCCAGG ATCGCCTCAC AGTGGGGGTG 
TACGAGTCGG CCAAGTTGAT GAATGTGGAC CCAGACAGCG TGGTCCTCTG CCTCTTGGCC 
ATTGACGAGG AGGAGGAGGA TGACATCGCC CTGCAAATCC ACTTCACGCT CATCCAGTCC 
TTCTGCTGTG ACAACGACAT CAACATCGTG CGGGTGTCGG GCATGCAGCG CCTGGCGCAG 
CTCCTGGGAG AGCCGGCCGA GACCCAGGGC ACCACCGAGG CCCGAGACCT GCATTGTCTC 
CTGGTCACGG TGAGTCGGGC CTCTGCCCTG CCCCGCCACG CCCGGGCACC TGGGCCGGTG 
TTTGTCAACA AAGTCGGGCT GACTGGTCCT GCACAGCTCA GCGCTCAGCC ACGTTTGGCA 
TGTCCCGTGG GCAGCCGGGC TGGGGCCTCC TCACCCAGGA AGCTATTTTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016882311.1
CDS	233..763
Translation	MTLEELVACDNAAQKMQTVTAAVEELLVAAQRQDRLTVGVYESAKLMNVDPDSVVLCLLAIDEEEEDDIALQIHFTLIQSFCCDNDINIVRVSGMQRLAQLLGEPAETQGTTEARDLHCLLVTVSRASALPRHARAPGPVFVNKVGLTGPAQLSAQPRLACPVGSRAGASSPRKLF

Target ORF information:

RefSeq Version	XM_017026822.1
Organism	Homo sapiens(human)
Definition	Homo sapiens growth arrest and DNA damage inducible beta (GADD45B), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017026822.1

ORF Insert Sequence:

ATGACGCTGG AAGAGCTCGT GGCGTGCGAC AACGCGGCGC AGAAGATGCA GACGGTGACC 
GCCGCGGTGG AGGAGCTTTT GGTGGCCGCT CAGCGCCAGG ATCGCCTCAC AGTGGGGGTG 
TACGAGTCGG CCAAGTTGAT GAATGTGGAC CCAGACAGCG TGGTCCTCTG CCTCTTGGCC 
ATTGACGAGG AGGAGGAGGA TGACATCGCC CTGCAAATCC ACTTCACGCT CATCCAGTCC 
TTCTGCTGTG ACAACGACAT CAACATCGTG CGGGTGTCGG GCATGCAGCG CCTGGCGCAG 
CTCCTGGGAG AGCCGGCCGA GACCCAGGGC ACCACCGAGG CCCGAGACCT GCATTGTCTC 
CTGGTCACGG TGAGTCGGGC CTCTGCCCTG CCCCGCCACG CCCGGGCACC TGGGCCGGTG 
TTTGTCAACA AAGTCGGGCT GACTGGTCCT GCACAGCTCA GCGCTCAGCC ACGTTTGGCA 
TGTCCCGTGG GCAGCCGGGC TGGGGCCTCC TCACCCAGGA AGCTATTTTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Matrine inhibits the progression of prostate cancer by promoting expression of GADD45B.
The Prostate(2018 Jan)
Huang H,Wang Q,Du T,Lin C,Lai Y,Zhu D,Wu W,Ma X,Bai S,Li Z,Liu L,Li Q

GADD45? loss ablates innate immunosuppression in cancer.
Cancer research(2017 Dec)
Verzella D,Bennett J,Fischietti M,Thotakura AK,Recordati C,Pasqualini F,Capece D,Vecchiotti D,D'Andrea D,Di Francesco B,De Maglie M,Begalli F,Tornatore L,Papa S,Lawrence T,Forbes S,Sica A,Alesse E,Zazzeroni F,Franzoso G

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GADD45B cDNA ORF clone, Homo sapiens(human)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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