MTX1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	MTX1
Entrez Gene ID	4580
Full Name	metaxin 1
Synonyms	MTX,MTXN
General protein information	Preferred Names metaxin 1 Names metaxin-1 mitochondrial outer membrane import complex protein 1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1q22
Disorder MIM:	600605

mRNA and Protein(s)

mRNA	Protein	Name
NM_198883.3	NP_942584.2	metaxin-1 isoform 2
NM_002455.4	NP_002446.3	metaxin-1 isoform 1

Pathways from BioSystems

Homologies

	LOC717595	XP_002808288.1
Bos taurus (cattle)	MTX1	NP_001035698.1
Danio rerio (zebrafish)	mtx1b	NP_001007281.1
Drosophila melanogaster (fruit fly)	CG9393	NP_649908.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP003981	XP_318431.5
Homo sapiens (human)	MTX1	NP_002446.2
Pan troglodytes (chimpanzee)	MTX1	XP_003308483.1
Rattus norvegicus (Norway rat)	Mtx1	NP_001094137.1
Canis lupus familiaris (dog)	MTX1	XP_537253.2
Mus musculus (house mouse)	Mtx1	NP_038632.2
Danio rerio (zebrafish)	mtx1a	NP_001121710.1
Caenorhabditis elegans (roundworm)	mtx-1	NP_493569.1

Gene Ontology
Bibliography

Related articles in PubMed

The phosphorylation of Metaxin 1 controls Bak activation during TNF? induced cell death.
Petit E, Cartron PF, Oliver L, Vallette FM
Cellular signalling30171-178(2017 Jan)

Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations.
Okada Y, Sim X, Go MJ, Wu JY, Gu D, Takeuchi F, Takahashi A, Maeda S, Tsunoda T, Chen P, Lim SC, Wong TY, Liu J, Young TL, Aung T, Seielstad M, Teo YY, Kim YJ, Lee JY, Han BG, Kang D, Chen CH, Tsai FJ, Chang LC, Fann SJ, Mei H, Rao DC, Hixson JE, Chen S, Katsuya T, Isono M, Ogihara T, Chambers JC, Zhang W, Kooner JS, , , Albrecht E, , Yamamoto K, Kubo M, Nakamura Y, Kamatani N, Kato N, He J, Chen YT, Cho YS, Tai ES, Tanaka T
Nature genetics44(8)904-9(2012 Jul)

Homozygosity for the MTX1 c.184T>A (p.S63T) alteration modifies the age of onset in GBA-associated Parkinson's disease.
Gan-Or Z, Bar-Shira A, Gurevich T, Giladi N, Orr-Urtreger A
Neurogenetics12(4)325-32(2011 Nov)

Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
Hendrickson SL, Lautenberger JA, Chinn LW, Malasky M, Sezgin E, Kingsley LA, Goedert JJ, Kirk GD, Gomperts ED, Buchbinder SP, Troyer JL, O'Brien SJ
PloS one5(9)e12862(2010 Sep)

The mitochondrial inner membrane protein mitofilin exists as a complex with SAM50, metaxins 1 and 2, coiled-coil-helix coiled-coil-helix domain-containing protein 3 and 6 and DnaJC11.
Xie J, Marusich MF, Souda P, Whitelegge J, Capaldi RA
FEBS letters581(18)3545-9(2007 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

after the induction of apoptosis, Bak switches from its association with Mtx2 and VDAC2 to a closer association with Mtx1.
Title: The phosphorylation of Metaxin 1 controls Bak activation during TNF? induced cell death.

Results describe the association between the MTX1 and beta-glucocerebrosidase genes and its possible effect on Parkinson disease.
Title: Homozygosity for the MTX1 c.184T>A (p.S63T) alteration modifies the age of onset in GBA-associated Parkinson's disease.

Observational study of gene-disease association. (HuGE Navigator)
Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.

mitofilin helps regulate mitochondrial morphology and at least four of the associated proteins (metaxins 1 and 2, SAM50 and CHCHD3) have been implicated in protein import
Title: The mitochondrial inner membrane protein mitofilin exists as a complex with SAM50, metaxins 1 and 2, coiled-coil-helix coiled-coil-helix domain-containing protein 3 and 6 and DnaJC11.

The pathway of Voltage-dependent anion-selective channel biogenesis in human mitochondria involves the TOM complex, Sam50 and metaxins, and that it is evolutionarily conserved.
Title: Conserved roles of Sam50 and metaxins in VDAC biogenesis.

The following MTX1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MTX1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu13768	NM_198883.3 Latest version!	Homo sapiens metaxin 1 (MTX1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$179.50-$251.30 $359.00
OHu23864	NM_002455.4 Latest version!	Homo sapiens metaxin 1 (MTX1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$272.30 $389.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

MTX1 ( NM_198883.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_942584.2 Homo sapiens metaxin 1 (MTX1), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu13768
Clone ID Related Accession (Same CDS sequence)	NM_198883.3
Accession Version	NM_198883.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1308bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-04
Organism	Homo sapiens(human)
Product	metaxin-1 isoform 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BG717732.1, BC001906.1 and AI241389.1. On Mar 26, 2014 this sequence version replaced NM_198883.2. Transcript Variant: This variant (2) lacks an exon in the coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC001906.1, BQ420450.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCTGCTCG GGGGACCCCC CCGCAGTCCC CGCTCGGGGA CGAGCCCCAA GGGGCCCTGG 
AGCAGTACAG GCCACGTGCA GTTTGGCAAG AGCCCCCAGA CCTGGCCCAG GCGCACAAGA 
CCCCGCTCTC CAGAGCCTGC CGCGCCTTCA GGGGTTCGGG GCTCCACTTG GACGAGGCGC 
CGTGACTCTC CGAGGCGCGC CGGGCCGACA GCGCTGTCCC GCTACGTGGG CCACCTCTGG 
ATGGGCCGGC GGCCGCCCTC CCCCGAGGCC CGCGGCCCAG TCCCCCGCAG TTCAGCTGCC 
AGTCGGGCCA GAAGAAGCCT CGCCTCCCCG GGGATCTCCC CAGGCCCCCT GACCGCAACG 
ATCGGAGGGG CGGTGGCGGG GGGCGGGCCC AGGCAGGGGA GGGCAGAAGC ACACAAGGAA 
GTGTTTCCGG GACAGAGGGT GGGCAAGATG GCGGCGCCCA TGGAGCTGTT CTGCTGGTCA 
GGGGGCTGGG GGCTGCCGTC AGTGGACCTG GACAGCCTGG CCGTGCTGAC CTATGCCAGA 
TTTACTGGTG CTCCACTGAA GGTACACAAG ATCAGCAACC CCTGGCAGAG CCCTTCAGGA 
ACTCTGCCTG CCCTTCGGAC CAGTCATGGA GAGGTCATCT CAGTTCCACA CAAGATCATC 
ACCCACCTTC GAAAAGAGGT ACATACTTTT TGGATAGACA CCAAGAACTA CGTGGAAGTG 
ACCCGGAAGT GGTATGCAGA GGCTATGCCC TTTCCCCTCA ACTTCTTCCT GCCTGGCCGC 
ATGCAGCGGC AGTACATGGA ACGGCTACAG CTGCTGACTG GGGAGCACAG GCCTGAGGAC 
GAGGAAGAGC TGGAGAAGGA GCTGTACCGA GAGGCTCGGG AGTGTCTGAC CCTGCTCTCT 
CAGCGCCTGG GCTCTCAAAA GTTCTTCTTT GGAGATGCCC CTGCCTCCTT GGACGCCTTC 
GTCTTCAGCT ACTTGGCCCT GCTGCTGCAG GCAAAGCTGC CCAGTGGGAA GCTGCAGGTC 
CACCTGCGTG GGCTGCACAA CCTCTGTGCC TATTGTACCC ACATTCTCAG TCTCTACTTC 
CCCTGGGATG GAGCTGAGGT ACCACCGCAA CGCCAGACAC CAGCAGGCCC AGAGACTGAG 
GAGGAGCCAT ACCGGCGCCG GAACCAGATC CTATCTGTGC TGGCAGGACT GGCAGCCATG 
GTGGGCTACG CCTTGCTCAG CGGCATTGTC TCCATCCAGC GGGCAACGCC TGCTCGGGCC 
CCAGGCACCC GGACCCTGGG CATGGCTGAG GAGGATGAAG AGGAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_942584.2
CDS	107..1414
Translation	MLLGGPPRSPRSGTSPKGPWSSTGHVQFGKSPQTWPRRTRPRSPEPAAPSGVRGSTWTRRRDSPRRAGPTALSRYVGHLWMGRRPPSPEARGPVPRSSAASRARRSLASPGISPGPLTATIGGAVAGGGPRQGRAEAHKEVFPGQRVGKMAAPMELFCWSGGWGLPSVDLDSLAVLTYARFTGAPLKVHKISNPWQSPSGTLPALRTSHGEVISVPHKIITHLRKEVHTFWIDTKNYVEVTRKWYAEAMPFPLNFFLPGRMQRQYMERLQLLTGEHRPEDEEELEKELYREARECLTLLSQRLGSQKFFFGDAPASLDAFVFSYLALLLQAKLPSGKLQVHLRGLHNLCAYCTHILSLYFPWDGAEVPPQRQTPAGPETEEEPYRRRNQILSVLAGLAAMVGYALLSGIVSIQRATPARAPGTRTLGMAEEDEEE

Target ORF information:

RefSeq Version	NM_198883.3
Organism	Homo sapiens(human)
Definition	Homo sapiens metaxin 1 (MTX1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_198883.3

ORF Insert Sequence:

ATGCTGCTCG GGGGACCCCC CCGCAGTCCC CGCTCGGGGA CGAGCCCCAA GGGGCCCTGG 
AGCAGTACAG GCCACGTGCA GTTTGGCAAG AGCCCCCAGA CCTGGCCCAG GCGCACAAGA 
CCCCGCTCTC CAGAGCCTGC CGCGCCTTCA GGGGTTCGGG GCTCCACTTG GACGAGGCGC 
CGTGACTCTC CGAGGCGCGC CGGGCCGACA GCGCTGTCCC GCTACGTGGG CCACCTCTGG 
ATGGGCCGGC GGCCGCCCTC CCCCGAGGCC CGCGGCCCAG TCCCCCGCAG TTCAGCTGCC 
AGTCGGGCCA GAAGAAGCCT CGCCTCCCCG GGGATCTCCC CAGGCCCCCT GACCGCAACG 
ATCGGAGGGG CGGTGGCGGG GGGCGGGCCC AGGCAGGGGA GGGCAGAAGC ACACAAGGAA 
GTGTTTCCGG GACAGAGGGT GGGCAAGATG GCGGCGCCCA TGGAGCTGTT CTGCTGGTCA 
GGGGGCTGGG GGCTGCCGTC AGTGGACCTG GACAGCCTGG CCGTGCTGAC CTATGCCAGA 
TTTACTGGTG CTCCACTGAA GGTACACAAG ATCAGCAACC CCTGGCAGAG CCCTTCAGGA 
ACTCTGCCTG CCCTTCGGAC CAGTCATGGA GAGGTCATCT CAGTTCCACA CAAGATCATC 
ACCCACCTTC GAAAAGAGGT ACATACTTTT TGGATAGACA CCAAGAACTA CGTGGAAGTG 
ACCCGGAAGT GGTATGCAGA GGCTATGCCC TTTCCCCTCA ACTTCTTCCT GCCTGGCCGC 
ATGCAGCGGC AGTACATGGA ACGGCTACAG CTGCTGACTG GGGAGCACAG GCCTGAGGAC 
GAGGAAGAGC TGGAGAAGGA GCTGTACCGA GAGGCTCGGG AGTGTCTGAC CCTGCTCTCT 
CAGCGCCTGG GCTCTCAAAA GTTCTTCTTT GGAGATGCCC CTGCCTCCTT GGACGCCTTC 
GTCTTCAGCT ACTTGGCCCT GCTGCTGCAG GCAAAGCTGC CCAGTGGGAA GCTGCAGGTC 
CACCTGCGTG GGCTGCACAA CCTCTGTGCC TATTGTACCC ACATTCTCAG TCTCTACTTC 
CCCTGGGATG GAGCTGAGGT ACCACCGCAA CGCCAGACAC CAGCAGGCCC AGAGACTGAG 
GAGGAGCCAT ACCGGCGCCG GAACCAGATC CTATCTGTGC TGGCAGGACT GGCAGCCATG 
GTGGGCTACG CCTTGCTCAG CGGCATTGTC TCCATCCAGC GGGCAACGCC TGCTCGGGCC 
CCAGGCACCC GGACCCTGGG CATGGCTGAG GAGGATGAAG AGGAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MTX1 ( NM_002455.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_002446.3 Homo sapiens metaxin 1 (MTX1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu23864
Clone ID Related Accession (Same CDS sequence)	NM_002455.4
Accession Version	NM_002455.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1401bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-04
Organism	Homo sapiens(human)
Product	metaxin-1 isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BG717732.1, AK313863.1, BC001906.1 and AI241389.1. On Mar 26, 2014 this sequence version replaced NM_002455.3. Transcript Variant: This variant (1) encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK313863.1, SRR1163655.498183.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END##

ATGCTGCTCG GGGGACCCCC CCGCAGTCCC CGCTCGGGGA CGAGCCCCAA GGGGCCCTGG 
AGCAGTACAG GCCACGTGCA GTTTGGCAAG AGCCCCCAGA CCTGGCCCAG GCGCACAAGA 
CCCCGCTCTC CAGAGCCTGC CGCGCCTTCA GGGGTTCGGG GCTCCACTTG GACGAGGCGC 
CGTGACTCTC CGAGGCGCGC CGGGCCGACA GCGCTGTCCC GCTACGTGGG CCACCTCTGG 
ATGGGCCGGC GGCCGCCCTC CCCCGAGGCC CGCGGCCCAG TCCCCCGCAG TTCAGCTGCC 
AGTCGGGCCA GAAGAAGCCT CGCCTCCCCG GGGATCTCCC CAGGCCCCCT GACCGCAACG 
ATCGGAGGGG CGGTGGCGGG GGGCGGGCCC AGGCAGGGGA GGGCAGAAGC ACACAAGGAA 
GTGTTTCCGG GACAGAGGGT GGGCAAGATG GCGGCGCCCA TGGAGCTGTT CTGCTGGTCA 
GGGGGCTGGG GGCTGCCGTC AGTGGACCTG GACAGCCTGG CCGTGCTGAC CTATGCCAGA 
TTTACTGGTG CTCCACTGAA GGTACACAAG ATCAGCAACC CCTGGCAGAG CCCTTCAGGA 
ACTCTGCCTG CCCTTCGGAC CAGTCATGGA GAGGTCATCT CAGTTCCACA CAAGATCATC 
ACCCACCTTC GAAAAGAGAA GTACAATGCT GATTATGATC TGTCAGCTCG GCAAGGGGCA 
GACACCCTGG CCTTCATGTC TCTCCTGGAG GAGAAGTTGC TCCCGGTGCT GGTACATACT 
TTTTGGATAG ACACCAAGAA CTACGTGGAA GTGACCCGGA AGTGGTATGC AGAGGCTATG 
CCCTTTCCCC TCAACTTCTT CCTGCCTGGC CGCATGCAGC GGCAGTACAT GGAACGGCTA 
CAGCTGCTGA CTGGGGAGCA CAGGCCTGAG GACGAGGAAG AGCTGGAGAA GGAGCTGTAC 
CGAGAGGCTC GGGAGTGTCT GACCCTGCTC TCTCAGCGCC TGGGCTCTCA AAAGTTCTTC 
TTTGGAGATG CCCCTGCCTC CTTGGACGCC TTCGTCTTCA GCTACTTGGC CCTGCTGCTG 
CAGGCAAAGC TGCCCAGTGG GAAGCTGCAG GTCCACCTGC GTGGGCTGCA CAACCTCTGT 
GCCTATTGTA CCCACATTCT CAGTCTCTAC TTCCCCTGGG ATGGAGCTGA GGTACCACCG 
CAACGCCAGA CACCAGCAGG CCCAGAGACT GAGGAGGAGC CATACCGGCG CCGGAACCAG 
ATCCTATCTG TGCTGGCAGG ACTGGCAGCC ATGGTGGGCT ACGCCTTGCT CAGCGGCATT 
GTCTCCATCC AGCGGGCAAC GCCTGCTCGG GCCCCAGGCA CCCGGACCCT GGGCATGGCT 
GAGGAGGATG AAGAGGAATG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002446.3
CDS	107..1507
Translation	MLLGGPPRSPRSGTSPKGPWSSTGHVQFGKSPQTWPRRTRPRSPEPAAPSGVRGSTWTRRRDSPRRAGPTALSRYVGHLWMGRRPPSPEARGPVPRSSAASRARRSLASPGISPGPLTATIGGAVAGGGPRQGRAEAHKEVFPGQRVGKMAAPMELFCWSGGWGLPSVDLDSLAVLTYARFTGAPLKVHKISNPWQSPSGTLPALRTSHGEVISVPHKIITHLRKEKYNADYDLSARQGADTLAFMSLLEEKLLPVLVHTFWIDTKNYVEVTRKWYAEAMPFPLNFFLPGRMQRQYMERLQLLTGEHRPEDEEELEKELYREARECLTLLSQRLGSQKFFFGDAPASLDAFVFSYLALLLQAKLPSGKLQVHLRGLHNLCAYCTHILSLYFPWDGAEVPPQRQTPAGPETEEEPYRRRNQILSVLAGLAAMVGYALLSGIVSIQRATPARAPGTRTLGMAEEDEEE

Target ORF information:

RefSeq Version	NM_002455.4
Organism	Homo sapiens(human)
Definition	Homo sapiens metaxin 1 (MTX1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002455.4

ORF Insert Sequence:

ATGCTGCTCG GGGGACCCCC CCGCAGTCCC CGCTCGGGGA CGAGCCCCAA GGGGCCCTGG 
AGCAGTACAG GCCACGTGCA GTTTGGCAAG AGCCCCCAGA CCTGGCCCAG GCGCACAAGA 
CCCCGCTCTC CAGAGCCTGC CGCGCCTTCA GGGGTTCGGG GCTCCACTTG GACGAGGCGC 
CGTGACTCTC CGAGGCGCGC CGGGCCGACA GCGCTGTCCC GCTACGTGGG CCACCTCTGG 
ATGGGCCGGC GGCCGCCCTC CCCCGAGGCC CGCGGCCCAG TCCCCCGCAG TTCAGCTGCC 
AGTCGGGCCA GAAGAAGCCT CGCCTCCCCG GGGATCTCCC CAGGCCCCCT GACCGCAACG 
ATCGGAGGGG CGGTGGCGGG GGGCGGGCCC AGGCAGGGGA GGGCAGAAGC ACACAAGGAA 
GTGTTTCCGG GACAGAGGGT GGGCAAGATG GCGGCGCCCA TGGAGCTGTT CTGCTGGTCA 
GGGGGCTGGG GGCTGCCGTC AGTGGACCTG GACAGCCTGG CCGTGCTGAC CTATGCCAGA 
TTTACTGGTG CTCCACTGAA GGTACACAAG ATCAGCAACC CCTGGCAGAG CCCTTCAGGA 
ACTCTGCCTG CCCTTCGGAC CAGTCATGGA GAGGTCATCT CAGTTCCACA CAAGATCATC 
ACCCACCTTC GAAAAGAGAA GTACAATGCT GATTATGATC TGTCAGCTCG GCAAGGGGCA 
GACACCCTGG CCTTCATGTC TCTCCTGGAG GAGAAGTTGC TCCCGGTGCT GGTACATACT 
TTTTGGATAG ACACCAAGAA CTACGTGGAA GTGACCCGGA AGTGGTATGC AGAGGCTATG 
CCCTTTCCCC TCAACTTCTT CCTGCCTGGC CGCATGCAGC GGCAGTACAT GGAACGGCTA 
CAGCTGCTGA CTGGGGAGCA CAGGCCTGAG GACGAGGAAG AGCTGGAGAA GGAGCTGTAC 
CGAGAGGCTC GGGAGTGTCT GACCCTGCTC TCTCAGCGCC TGGGCTCTCA AAAGTTCTTC 
TTTGGAGATG CCCCTGCCTC CTTGGACGCC TTCGTCTTCA GCTACTTGGC CCTGCTGCTG 
CAGGCAAAGC TGCCCAGTGG GAAGCTGCAG GTCCACCTGC GTGGGCTGCA CAACCTCTGT 
GCCTATTGTA CCCACATTCT CAGTCTCTAC TTCCCCTGGG ATGGAGCTGA GGTACCACCG 
CAACGCCAGA CACCAGCAGG CCCAGAGACT GAGGAGGAGC CATACCGGCG CCGGAACCAG 
ATCCTATCTG TGCTGGCAGG ACTGGCAGCC ATGGTGGGCT ACGCCTTGCT CAGCGGCATT 
GTCTCCATCC AGCGGGCAAC GCCTGCTCGG GCCCCAGGCA CCCGGACCCT GGGCATGGCT 
GAGGAGGATG AAGAGGAATG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The phosphorylation of Metaxin 1 controls Bak activation during TNF? induced cell death.
Cellular signalling30171-178(2017 Jan)
Petit E,Cartron PF,Oliver L,Vallette FM

Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations.
Nature genetics44(8)904-9(2012 Jul)
Okada Y,Sim X,Go MJ,Wu JY,Gu D,Takeuchi F,Takahashi A,Maeda S,Tsunoda T,Chen P,Lim SC,Wong TY,Liu J,Young TL,Aung T,Seielstad M,Teo YY,Kim YJ,Lee JY,Han BG,Kang D,Chen CH,Tsai FJ,Chang LC,Fann SJ,Mei H,Rao DC,Hixson JE,Chen S,Katsuya T,Isono M,Ogihara T,Chambers JC,Zhang W,Kooner JS,,,Albrecht E,,Yamamoto K,Kubo M,Nakamura Y,Kamatani N,Kato N,He J,Chen YT,Cho YS,Tai ES,Tanaka T

Homozygosity for the MTX1 c.184T>A (p.S63T) alteration modifies the age of onset in GBA-associated Parkinson's disease.
Neurogenetics12(4)325-32(2011 Nov)
Gan-Or Z,Bar-Shira A,Gurevich T,Giladi N,Orr-Urtreger A

Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
PloS one5(9)e12862(2010 Sep)
Hendrickson SL,Lautenberger JA,Chinn LW,Malasky M,Sezgin E,Kingsley LA,Goedert JJ,Kirk GD,Gomperts ED,Buchbinder SP,Troyer JL,O'Brien SJ

The mitochondrial inner membrane protein mitofilin exists as a complex with SAM50, metaxins 1 and 2, coiled-coil-helix coiled-coil-helix domain-containing protein 3 and 6 and DnaJC11.
FEBS letters581(18)3545-9(2007 Jul)
Xie J,Marusich MF,Souda P,Whitelegge J,Capaldi RA

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MTX1 cDNA ORF clone, Homo sapiens(human)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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