MTTP cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	MTTP
Entrez Gene ID	4547
Full Name	microsomal triglyceride transfer protein
Synonyms	ABL,MTP
General protein information	Preferred Names microsomal triglyceride transfer protein Names microsomal triglyceride transfer protein large subunit microsomal triglyceride transfer protein (large polypeptide, 88kDa)
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 4 Map Location: 4q23
Summary	MTP encodes the large subunit of the heterodimeric microsomal triglyceride transfer protein. Protein disulfide isomerase (PDI) completes the heterodimeric microsomal triglyceride transfer protein, which has been shown to play a central role in lipoprotein assembly. Mutations in MTP can cause abetalipoproteinemia. [provided by RefSeq, Jul 2008].
Disorder MIM:	157147
Disorder Html:	Abetalipoproteinemia, 200100 (3); {Metabolic syndrome, protection against}, 605552 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_000253.3	NP_000244.2	microsomal triglyceride transfer protein large subunit isoform 1 precursor
NM_001300785.1	NP_001287714.1	microsomal triglyceride transfer protein large subunit isoform 2

Pathways from BioSystems

Homologies

Bos taurus (cattle)	MTTP	NP_001095304.1
Danio rerio (zebrafish)	mtp	NP_998135.1
Xenopus tropicalis (tropical clawed frog)	LOC100487453	XP_002934813.1
Pan troglodytes (chimpanzee)	MTTP	XP_001167562.1
Drosophila melanogaster (fruit fly)	Mtp	NP_610075.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP010234	XP_319421.4
	MTTP	XP_001107709.1
Rattus norvegicus (Norway rat)	Mttp	NP_001101197.1
Gallus gallus (chicken)	MTTP	NP_001103254.1
Homo sapiens (human)	MTTP	NP_000244.2
Canis lupus familiaris (dog)	MTTP	XP_544995.3
Mus musculus (house mouse)	Mttp	NP_032668.2

Gene Ontology
Bibliography

Related articles in PubMed

Association of MTTP gene variants with pediatric NAFLD: A candidate-gene-based analysis of single nucleotide variations in obese children.
Dai D, Wen F, Zhou S, Su Z, Liu G, Wang M, Zhou J, He F
PloS one12(9)e0185396(2017)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data suggest that amphipathic beta-strands in 200 N-terminal residues of beta1 domain of APOB are required for secretion of lipid-rich or lipid-poor particles; residues 300-700 or 1050-1500 of beta1 domain appear to be required for secretion of lipid-rich particles; MTTP is required for secretion of intact APOB but not of truncated APOB. (APOB = apolipoprotein B; MTTP = microsomal triglyceride transfer protein)
Title: Relationship between Amphipathic ? Structures in the ?

In chronic hepatitis C patients infected with HCV genotype 3 and with the TT/GT genotype of the MTTP -493G/T SNP, a significant increase in hepatic steatosis was observed, which may indicate that this SNP has a significant influence on the accumulation of triglycerides in hepatocytes.
Title: Genetic variation in the microsomal triglyceride transfer protein (-493G/T) is associated with hepatic steatosis in patients infected with hepatitis C virus.

results of this study, examining a cohort of obese children, suggest that the genetic variation at MTTP rs2306986 was associated with higher susceptibility to NAFLD
Title: Association of MTTP gene variants with pediatric NAFLD: A candidate-gene-based analysis of single nucleotide variations in obese children.

High expression of MTTP is associated with high carotid intima-media thickness.
Title: Vascular Disease Is Associated With the Expression of Genes for Intestinal Cholesterol Transport and Metabolism.

two new hypolipidemic patients with very low plasma triglyceride and apolipoprotein B (apoB) levels with plasma lipid profiles similar to abetalipoproteinemia (ABL) patients, are reported.
Title: Structure-function analyses of microsomal triglyceride transfer protein missense mutations in abetalipoproteinemia and hypobetalipoproteinemia subjects.

The following MTTP gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MTTP cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu26041	NM_000253.3 Latest version!	Homo sapiens microsomal triglyceride transfer protein (MTTP), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$339.50-$475.30 $679.00
OHu38948	NM_001300785.1 Latest version!	Homo sapiens microsomal triglyceride transfer protein (MTTP), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$475.30 $679.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

MTTP ( NM_000253.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_000244.2 Homo sapiens microsomal triglyceride transfer protein (MTTP), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu26041
Clone ID Related Accession (Same CDS sequence)	NM_000253.3
Accession Version	NM_000253.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2685bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-16
Organism	Homo sapiens(human)
Product	microsomal triglyceride transfer protein large subunit isoform 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB458800.2, BC125110.1, CB162574.1, BE047932.1, AI623321.1 and X91148.1. This sequence is a reference standard in the RefSeqGene project. On Jul 12, 2014 this sequence version replaced NM_000253.2. Transcript Variant: This variant (1) represents the longer transcript but encodes the shorter isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660809.84471.1, SRR1803611.206611.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA1970526 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGATTCTTC TTGCTGTGCT TTTTCTCTGC TTCATTTCCT CATATTCAGC TTCTGTTAAA 
GGTCACACAA CTGGTCTCTC ATTAAATAAT GACCGGCTGT ACAAGCTCAC GTACTCCACT 
GAAGTTCTTC TTGATCGGGG CAAAGGAAAA CTGCAAGACA GCGTGGGCTA CCGCATTTCC 
TCCAACGTGG ATGTGGCCTT ACTATGGAGG AATCCTGATG GTGATGATGA CCAGTTGATC 
CAAATAACGA TGAAGGATGT AAATGTTGAA AATGTGAATC AGCAGAGAGG AGAGAAGAGC 
ATCTTCAAAG GAAAAAGCCC ATCTAAAATA ATGGGAAAGG AAAACTTGGA AGCTCTGCAA 
AGACCTACGC TCCTTCATCT AATCCATGGA AAGGTCAAAG AGTTCTACTC ATATCAAAAT 
GAGGCAGTGG CCATAGAAAA TATCAAGAGA GGTCTGGCTA GCCTATTTCA GACACAGTTA 
AGCTCTGGAA CCACCAATGA GGTAGATATC TCTGGAAATT GTAAAGTGAC CTACCAGGCT 
CATCAAGACA AAGTGATCAA AATTAAGGCC TTGGATTCAT GCAAAATAGC GAGGTCTGGA 
TTTACGACCC CAAATCAGGT CTTGGGTGTC AGTTCAAAAG CTACATCTGT CACCACCTAT 
AAGATAGAAG ACAGCTTTGT TATAGCTGTG CTTGCTGAAG AAACACACAA TTTTGGACTG 
AATTTCCTAC AAACCATTAA GGGGAAAATA GTATCGAAGC AGAAATTAGA GCTGAAGACA 
ACCGAAGCAG GCCCAAGATT GATGTCTGGA AAGCAGGCTG CAGCCATAAT CAAAGCAGTT 
GATTCAAAGT ACACGGCCAT TCCCATTGTG GGGCAGGTCT TCCAGAGCCA CTGTAAAGGA 
TGTCCTTCTC TCTCGGAGCT CTGGCGGTCC ACCAGGAAAT ACCTGCAGCC TGACAACCTT 
TCCAAGGCTG AGGCTGTCAG AAACTTCCTG GCCTTCATTC AGCACCTCAG GACTGCGAAG 
AAAGAAGAGA TCCTTCAAAT ACTAAAGATG GAAAATAAGG AAGTATTACC TCAGCTGGTG 
GATGCTGTCA CCTCTGCTCA GACCTCAGAC TCATTAGAAG CCATTTTGGA CTTTTTGGAT 
TTCAAAAGTG ACAGCAGCAT TATCCTCCAG GAGAGGTTTC TCTATGCCTG TGGATTTGCT 
TCTCATCCCA ATGAAGAACT CCTGAGAGCC CTCATTAGTA AGTTCAAAGG TTCTATTGGT 
AGCAGTGACA TCAGAGAAAC TGTTATGATC ATCACTGGGA CACTTGTCAG AAAGTTGTGT 
CAGAATGAAG GCTGCAAACT CAAAGCAGTA GTGGAAGCTA AGAAGTTAAT CCTGGGAGGA 
CTTGAAAAAG CAGAGAAAAA AGAGGACACC AGGATGTATC TGCTGGCTTT GAAGAATGCC 
CTGCTTCCAG AAGGCATCCC AAGTCTTCTG AAGTATGCAG AAGCAGGAGA AGGGCCCATC 
AGCCACCTGG CTACCACTGC TCTCCAGAGA TATGATCTCC CTTTCATAAC TGATGAGGTG 
AAGAAGACCT TAAACAGAAT ATACCACCAA AACCGTAAAG TTCATGAAAA GACTGTGCGC 
ACTGCTGCAG CTGCTATCAT TTTAAATAAC AATCCATCCT ACATGGACGT CAAGAACATC 
CTGCTGTCTA TTGGGGAGCT TCCCCAAGAA ATGAATAAAT ACATGCTCGC CATTGTTCAA 
GACATCCTAC GTTTTGAAAT GCCTGCAAGC AAAATTGTCC GTCGAGTTCT GAAGGAAATG 
GTCGCTCACA ATTATGACCG TTTCTCCAGG AGTGGATCTT CTTCTGCCTA CACTGGCTAC 
ATAGAACGTA GTCCCCGTTC GGCATCTACT TACAGCCTAG ACATTCTCTA CTCGGGTTCT 
GGCATTCTAA GGAGAAGTAA CCTGAACATC TTTCAGTACA TTGGGAAGGC TGGTCTTCAC 
GGTAGCCAGG TGGTTATTGA AGCCCAAGGA CTGGAAGCCT TAATCGCAGC CACCCCTGAC 
GAGGGGGAGG AGAACCTTGA CTCCTATGCT GGTATGTCAG CCATCCTCTT TGATGTTCAG 
CTCAGACCTG TCACCTTTTT CAACGGATAC AGTGATTTGA TGTCCAAAAT GCTGTCAGCA 
TCTGGCGACC CTATCAGTGT GGTGAAAGGA CTTATTCTGC TAATAGATCA TTCTCAGGAA 
CTTCAGTTAC AATCTGGACT AAAAGCCAAT ATAGAGGTCC AGGGTGGTCT AGCTATTGAT 
ATTTCAGGTG CAATGGAGTT TAGCTTGTGG TATCGTGAGT CTAAAACCCG AGTGAAAAAT 
AGGGTGACTG TGGTAATAAC CACTGACATC ACAGTGGACT CCTCTTTTGT GAAAGCTGGC 
CTGGAAACCA GTACAGAAAC AGAAGCAGGC TTGGAGTTTA TCTCCACAGT GCAGTTTTCT 
CAGTACCCAT TCTTAGTTTG CATGCAGATG GACAAGGATG AAGCTCCATT CAGGCAATTT 
GAGAAAAAGT ACGAAAGGCT GTCCACAGGC AGAGGTTATG TCTCTCAGAA AAGAAAAGAA 
AGCGTATTAG CAGGATGTGA ATTCCCGCTC CATCAAGAGA ACTCAGAGAT GTGCAAAGTG 
GTGTTTGCCC CTCAGCCGGA TAGTACTTCC AGCGGATGGT TTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000244.2
CDS	262..2946
Translation	MILLAVLFLCFISSYSASVKGHTTGLSLNNDRLYKLTYSTEVLLDRGKGKLQDSVGYRISSNVDVALLWRNPDGDDDQLIQITMKDVNVENVNQQRGEKSIFKGKSPSKIMGKENLEALQRPTLLHLIHGKVKEFYSYQNEAVAIENIKRGLASLFQTQLSSGTTNEVDISGNCKVTYQAHQDKVIKIKALDSCKIARSGFTTPNQVLGVSSKATSVTTYKIEDSFVIAVLAEETHNFGLNFLQTIKGKIVSKQKLELKTTEAGPRLMSGKQAAAIIKAVDSKYTAIPIVGQVFQSHCKGCPSLSELWRSTRKYLQPDNLSKAEAVRNFLAFIQHLRTAKKEEILQILKMENKEVLPQLVDAVTSAQTSDSLEAILDFLDFKSDSSIILQERFLYACGFASHPNEELLRALISKFKGSIGSSDIRETVMIITGTLVRKLCQNEGCKLKAVVEAKKLILGGLEKAEKKEDTRMYLLALKNALLPEGIPSLLKYAEAGEGPISHLATTALQRYDLPFITDEVKKTLNRIYHQNRKVHEKTVRTAAAAIILNNNPSYMDVKNILLSIGELPQEMNKYMLAIVQDILRFEMPASKIVRRVLKEMVAHNYDRFSRSGSSSAYTGYIERSPRSASTYSLDILYSGSGILRRSNLNIFQYIGKAGLHGSQVVIEAQGLEALIAATPDEGEENLDSYAGMSAILFDVQLRPVTFFNGYSDLMSKMLSASGDPISVVKGLILLIDHSQELQLQSGLKANIEVQGGLAIDISGAMEFSLWYRESKTRVKNRVTVVITTDITVDSSFVKAGLETSTETEAGLEFISTVQFSQYPFLVCMQMDKDEAPFRQFEKKYERLSTGRGYVSQKRKESVLAGCEFPLHQENSEMCKVVFAPQPDSTSSGWF

Target ORF information:

RefSeq Version	NM_000253.3
Organism	Homo sapiens(human)
Definition	Homo sapiens microsomal triglyceride transfer protein (MTTP), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000253.3

ORF Insert Sequence:

ATGATTCTTC TTGCTGTGCT TTTTCTCTGC TTCATTTCCT CATATTCAGC TTCTGTTAAA 
GGTCACACAA CTGGTCTCTC ATTAAATAAT GACCGGCTGT ACAAGCTCAC GTACTCCACT 
GAAGTTCTTC TTGATCGGGG CAAAGGAAAA CTGCAAGACA GCGTGGGCTA CCGCATTTCC 
TCCAACGTGG ATGTGGCCTT ACTATGGAGG AATCCTGATG GTGATGATGA CCAGTTGATC 
CAAATAACGA TGAAGGATGT AAATGTTGAA AATGTGAATC AGCAGAGAGG AGAGAAGAGC 
ATCTTCAAAG GAAAAAGCCC ATCTAAAATA ATGGGAAAGG AAAACTTGGA AGCTCTGCAA 
AGACCTACGC TCCTTCATCT AATCCATGGA AAGGTCAAAG AGTTCTACTC ATATCAAAAT 
GAGGCAGTGG CCATAGAAAA TATCAAGAGA GGTCTGGCTA GCCTATTTCA GACACAGTTA 
AGCTCTGGAA CCACCAATGA GGTAGATATC TCTGGAAATT GTAAAGTGAC CTACCAGGCT 
CATCAAGACA AAGTGATCAA AATTAAGGCC TTGGATTCAT GCAAAATAGC GAGGTCTGGA 
TTTACGACCC CAAATCAGGT CTTGGGTGTC AGTTCAAAAG CTACATCTGT CACCACCTAT 
AAGATAGAAG ACAGCTTTGT TATAGCTGTG CTTGCTGAAG AAACACACAA TTTTGGACTG 
AATTTCCTAC AAACCATTAA GGGGAAAATA GTATCGAAGC AGAAATTAGA GCTGAAGACA 
ACCGAAGCAG GCCCAAGATT GATGTCTGGA AAGCAGGCTG CAGCCATAAT CAAAGCAGTT 
GATTCAAAGT ACACGGCCAT TCCCATTGTG GGGCAGGTCT TCCAGAGCCA CTGTAAAGGA 
TGTCCTTCTC TCTCGGAGCT CTGGCGGTCC ACCAGGAAAT ACCTGCAGCC TGACAACCTT 
TCCAAGGCTG AGGCTGTCAG AAACTTCCTG GCCTTCATTC AGCACCTCAG GACTGCGAAG 
AAAGAAGAGA TCCTTCAAAT ACTAAAGATG GAAAATAAGG AAGTATTACC TCAGCTGGTG 
GATGCTGTCA CCTCTGCTCA GACCTCAGAC TCATTAGAAG CCATTTTGGA CTTTTTGGAT 
TTCAAAAGTG ACAGCAGCAT TATCCTCCAG GAGAGGTTTC TCTATGCCTG TGGATTTGCT 
TCTCATCCCA ATGAAGAACT CCTGAGAGCC CTCATTAGTA AGTTCAAAGG TTCTATTGGT 
AGCAGTGACA TCAGAGAAAC TGTTATGATC ATCACTGGGA CACTTGTCAG AAAGTTGTGT 
CAGAATGAAG GCTGCAAACT CAAAGCAGTA GTGGAAGCTA AGAAGTTAAT CCTGGGAGGA 
CTTGAAAAAG CAGAGAAAAA AGAGGACACC AGGATGTATC TGCTGGCTTT GAAGAATGCC 
CTGCTTCCAG AAGGCATCCC AAGTCTTCTG AAGTATGCAG AAGCAGGAGA AGGGCCCATC 
AGCCACCTGG CTACCACTGC TCTCCAGAGA TATGATCTCC CTTTCATAAC TGATGAGGTG 
AAGAAGACCT TAAACAGAAT ATACCACCAA AACCGTAAAG TTCATGAAAA GACTGTGCGC 
ACTGCTGCAG CTGCTATCAT TTTAAATAAC AATCCATCCT ACATGGACGT CAAGAACATC 
CTGCTGTCTA TTGGGGAGCT TCCCCAAGAA ATGAATAAAT ACATGCTCGC CATTGTTCAA 
GACATCCTAC GTTTTGAAAT GCCTGCAAGC AAAATTGTCC GTCGAGTTCT GAAGGAAATG 
GTCGCTCACA ATTATGACCG TTTCTCCAGG AGTGGATCTT CTTCTGCCTA CACTGGCTAC 
ATAGAACGTA GTCCCCGTTC GGCATCTACT TACAGCCTAG ACATTCTCTA CTCGGGTTCT 
GGCATTCTAA GGAGAAGTAA CCTGAACATC TTTCAGTACA TTGGGAAGGC TGGTCTTCAC 
GGTAGCCAGG TGGTTATTGA AGCCCAAGGA CTGGAAGCCT TAATCGCAGC CACCCCTGAC 
GAGGGGGAGG AGAACCTTGA CTCCTATGCT GGTATGTCAG CCATCCTCTT TGATGTTCAG 
CTCAGACCTG TCACCTTTTT CAACGGATAC AGTGATTTGA TGTCCAAAAT GCTGTCAGCA 
TCTGGCGACC CTATCAGTGT GGTGAAAGGA CTTATTCTGC TAATAGATCA TTCTCAGGAA 
CTTCAGTTAC AATCTGGACT AAAAGCCAAT ATAGAGGTCC AGGGTGGTCT AGCTATTGAT 
ATTTCAGGTG CAATGGAGTT TAGCTTGTGG TATCGTGAGT CTAAAACCCG AGTGAAAAAT 
AGGGTGACTG TGGTAATAAC CACTGACATC ACAGTGGACT CCTCTTTTGT GAAAGCTGGC 
CTGGAAACCA GTACAGAAAC AGAAGCAGGC TTGGAGTTTA TCTCCACAGT GCAGTTTTCT 
CAGTACCCAT TCTTAGTTTG CATGCAGATG GACAAGGATG AAGCTCCATT CAGGCAATTT 
GAGAAAAAGT ACGAAAGGCT GTCCACAGGC AGAGGTTATG TCTCTCAGAA AAGAAAAGAA 
AGCGTATTAG CAGGATGTGA ATTCCCGCTC CATCAAGAGA ACTCAGAGAT GTGCAAAGTG 
GTGTTTGCCC CTCAGCCGGA TAGTACTTCC AGCGGATGGT TTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MTTP ( NM_001300785.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001287714.1 Homo sapiens microsomal triglyceride transfer protein (MTTP), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu38948
Clone ID Related Accession (Same CDS sequence)	NM_001300785.1
Accession Version	NM_001300785.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2766bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-15
Organism	Homo sapiens(human)
Product	microsomal triglyceride transfer protein large subunit isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB458800.2, AK302602.1, BC125110.1, CB162574.1, BE047932.1, AI623321.1 and X91148.1. On Jul 12, 2014 this sequence version replaced XM_005263025.1. Transcript Variant: This variant (2) differs in its 5' UTR and coding region, compared to variant 1. The encoded isoform (2) has a longer and distinct N-terminus, compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK302602.1, SRR1660807.210638.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2148093 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAAGAAA GGGGAGGGGT TTATGCGGGG CGGGGTCTGG AGTTAGTGTT TTGGGAGTGG 
GAGGTAGTTA CAGTGATGTC TGTTTTTTCC CGTTCAAGAA TTAAGTGTGT ACCTGCAGAC 
GTGTATTCAT TCATATATTC TTGTCACACA ACTGGTCTCT CATTAAATAA TGACCGGCTG 
TACAAGCTCA CGTACTCCAC TGAAGTTCTT CTTGATCGGG GCAAAGGAAA ACTGCAAGAC 
AGCGTGGGCT ACCGCATTTC CTCCAACGTG GATGTGGCCT TACTATGGAG GAATCCTGAT 
GGTGATGATG ACCAGTTGAT CCAAATAACG ATGAAGGATG TAAATGTTGA AAATGTGAAT 
CAGCAGAGAG GAGAGAAGAG CATCTTCAAA GGAAAAAGCC CATCTAAAAT AATGGGAAAG 
GAAAACTTGG AAGCTCTGCA AAGACCTACG CTCCTTCATC TAATCCATGG AAAGGTCAAA 
GAGTTCTACT CATATCAAAA TGAGGCAGTG GCCATAGAAA ATATCAAGAG AGGTCTGGCT 
AGCCTATTTC AGACACAGTT AAGCTCTGGA ACCACCAATG AGGTAGATAT CTCTGGAAAT 
TGTAAAGTGA CCTACCAGGC TCATCAAGAC AAAGTGATCA AAATTAAGGC CTTGGATTCA 
TGCAAAATAG CGAGGTCTGG ATTTACGACC CCAAATCAGG TCTTGGGTGT CAGTTCAAAA 
GCTACATCTG TCACCACCTA TAAGATAGAA GACAGCTTTG TTATAGCTGT GCTTGCTGAA 
GAAACACACA ATTTTGGACT GAATTTCCTA CAAACCATTA AGGGGAAAAT AGTATCGAAG 
CAGAAATTAG AGCTGAAGAC AACCGAAGCA GGCCCAAGAT TGATGTCTGG AAAGCAGGCT 
GCAGCCATAA TCAAAGCAGT TGATTCAAAG TACACGGCCA TTCCCATTGT GGGGCAGGTC 
TTCCAGAGCC ACTGTAAAGG ATGTCCTTCT CTCTCGGAGC TCTGGCGGTC CACCAGGAAA 
TACCTGCAGC CTGACAACCT TTCCAAGGCT GAGGCTGTCA GAAACTTCCT GGCCTTCATT 
CAGCACCTCA GGACTGCGAA GAAAGAAGAG ATCCTTCAAA TACTAAAGAT GGAAAATAAG 
GAAGTATTAC CTCAGCTGGT GGATGCTGTC ACCTCTGCTC AGACCTCAGA CTCATTAGAA 
GCCATTTTGG ACTTTTTGGA TTTCAAAAGT GACAGCAGCA TTATCCTCCA GGAGAGGTTT 
CTCTATGCCT GTGGATTTGC TTCTCATCCC AATGAAGAAC TCCTGAGAGC CCTCATTAGT 
AAGTTCAAAG GTTCTATTGG TAGCAGTGAC ATCAGAGAAA CTGTTATGAT CATCACTGGG 
ACACTTGTCA GAAAGTTGTG TCAGAATGAA GGCTGCAAAC TCAAAGCAGT AGTGGAAGCT 
AAGAAGTTAA TCCTGGGAGG ACTTGAAAAA GCAGAGAAAA AAGAGGACAC CAGGATGTAT 
CTGCTGGCTT TGAAGAATGC CCTGCTTCCA GAAGGCATCC CAAGTCTTCT GAAGTATGCA 
GAAGCAGGAG AAGGGCCCAT CAGCCACCTG GCTACCACTG CTCTCCAGAG ATATGATCTC 
CCTTTCATAA CTGATGAGGT GAAGAAGACC TTAAACAGAA TATACCACCA AAACCGTAAA 
GTTCATGAAA AGACTGTGCG CACTGCTGCA GCTGCTATCA TTTTAAATAA CAATCCATCC 
TACATGGACG TCAAGAACAT CCTGCTGTCT ATTGGGGAGC TTCCCCAAGA AATGAATAAA 
TACATGCTCG CCATTGTTCA AGACATCCTA CGTTTTGAAA TGCCTGCAAG CAAAATTGTC 
CGTCGAGTTC TGAAGGAAAT GGTCGCTCAC AATTATGACC GTTTCTCCAG GAGTGGATCT 
TCTTCTGCCT ACACTGGCTA CATAGAACGT AGTCCCCGTT CGGCATCTAC TTACAGCCTA 
GACATTCTCT ACTCGGGTTC TGGCATTCTA AGGAGAAGTA ACCTGAACAT CTTTCAGTAC 
ATTGGGAAGG CTGGTCTTCA CGGTAGCCAG GTGGTTATTG AAGCCCAAGG ACTGGAAGCC 
TTAATCGCAG CCACCCCTGA CGAGGGGGAG GAGAACCTTG ACTCCTATGC TGGTATGTCA 
GCCATCCTCT TTGATGTTCA GCTCAGACCT GTCACCTTTT TCAACGGATA CAGTGATTTG 
ATGTCCAAAA TGCTGTCAGC ATCTGGCGAC CCTATCAGTG TGGTGAAAGG ACTTATTCTG 
CTAATAGATC ATTCTCAGGA ACTTCAGTTA CAATCTGGAC TAAAAGCCAA TATAGAGGTC 
CAGGGTGGTC TAGCTATTGA TATTTCAGGT GCAATGGAGT TTAGCTTGTG GTATCGTGAG 
TCTAAAACCC GAGTGAAAAA TAGGGTGACT GTGGTAATAA CCACTGACAT CACAGTGGAC 
TCCTCTTTTG TGAAAGCTGG CCTGGAAACC AGTACAGAAA CAGAAGCAGG CTTGGAGTTT 
ATCTCCACAG TGCAGTTTTC TCAGTACCCA TTCTTAGTTT GCATGCAGAT GGACAAGGAT 
GAAGCTCCAT TCAGGCAATT TGAGAAAAAG TACGAAAGGC TGTCCACAGG CAGAGGTTAT 
GTCTCTCAGA AAAGAAAAGA AAGCGTATTA GCAGGATGTG AATTCCCGCT CCATCAAGAG 
AACTCAGAGA TGTGCAAAGT GGTGTTTGCC CCTCAGCCGG ATAGTACTTC CAGCGGATGG 
TTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001287714.1
CDS	19..2784
Translation	MEERGGVYAGRGLELVFWEWEVVTVMSVFSRSRIKCVPADVYSFIYSCHTTGLSLNNDRLYKLTYSTEVLLDRGKGKLQDSVGYRISSNVDVALLWRNPDGDDDQLIQITMKDVNVENVNQQRGEKSIFKGKSPSKIMGKENLEALQRPTLLHLIHGKVKEFYSYQNEAVAIENIKRGLASLFQTQLSSGTTNEVDISGNCKVTYQAHQDKVIKIKALDSCKIARSGFTTPNQVLGVSSKATSVTTYKIEDSFVIAVLAEETHNFGLNFLQTIKGKIVSKQKLELKTTEAGPRLMSGKQAAAIIKAVDSKYTAIPIVGQVFQSHCKGCPSLSELWRSTRKYLQPDNLSKAEAVRNFLAFIQHLRTAKKEEILQILKMENKEVLPQLVDAVTSAQTSDSLEAILDFLDFKSDSSIILQERFLYACGFASHPNEELLRALISKFKGSIGSSDIRETVMIITGTLVRKLCQNEGCKLKAVVEAKKLILGGLEKAEKKEDTRMYLLALKNALLPEGIPSLLKYAEAGEGPISHLATTALQRYDLPFITDEVKKTLNRIYHQNRKVHEKTVRTAAAAIILNNNPSYMDVKNILLSIGELPQEMNKYMLAIVQDILRFEMPASKIVRRVLKEMVAHNYDRFSRSGSSSAYTGYIERSPRSASTYSLDILYSGSGILRRSNLNIFQYIGKAGLHGSQVVIEAQGLEALIAATPDEGEENLDSYAGMSAILFDVQLRPVTFFNGYSDLMSKMLSASGDPISVVKGLILLIDHSQELQLQSGLKANIEVQGGLAIDISGAMEFSLWYRESKTRVKNRVTVVITTDITVDSSFVKAGLETSTETEAGLEFISTVQFSQYPFLVCMQMDKDEAPFRQFEKKYERLSTGRGYVSQKRKESVLAGCEFPLHQENSEMCKVVFAPQPDSTSSGWF

Target ORF information:

RefSeq Version	NM_001300785.1
Organism	Homo sapiens(human)
Definition	Homo sapiens microsomal triglyceride transfer protein (MTTP), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001300785.1

ORF Insert Sequence:

ATGGAAGAAA GGGGAGGGGT TTATGCGGGG CGGGGTCTGG AGTTAGTGTT TTGGGAGTGG 
GAGGTAGTTA CAGTGATGTC TGTTTTTTCC CGTTCAAGAA TTAAGTGTGT ACCTGCAGAC 
GTGTATTCAT TCATATATTC TTGTCACACA ACTGGTCTCT CATTAAATAA TGACCGGCTG 
TACAAGCTCA CGTACTCCAC TGAAGTTCTT CTTGATCGGG GCAAAGGAAA ACTGCAAGAC 
AGCGTGGGCT ACCGCATTTC CTCCAACGTG GATGTGGCCT TACTATGGAG GAATCCTGAT 
GGTGATGATG ACCAGTTGAT CCAAATAACG ATGAAGGATG TAAATGTTGA AAATGTGAAT 
CAGCAGAGAG GAGAGAAGAG CATCTTCAAA GGAAAAAGCC CATCTAAAAT AATGGGAAAG 
GAAAACTTGG AAGCTCTGCA AAGACCTACG CTCCTTCATC TAATCCATGG AAAGGTCAAA 
GAGTTCTACT CATATCAAAA TGAGGCAGTG GCCATAGAAA ATATCAAGAG AGGTCTGGCT 
AGCCTATTTC AGACACAGTT AAGCTCTGGA ACCACCAATG AGGTAGATAT CTCTGGAAAT 
TGTAAAGTGA CCTACCAGGC TCATCAAGAC AAAGTGATCA AAATTAAGGC CTTGGATTCA 
TGCAAAATAG CGAGGTCTGG ATTTACGACC CCAAATCAGG TCTTGGGTGT CAGTTCAAAA 
GCTACATCTG TCACCACCTA TAAGATAGAA GACAGCTTTG TTATAGCTGT GCTTGCTGAA 
GAAACACACA ATTTTGGACT GAATTTCCTA CAAACCATTA AGGGGAAAAT AGTATCGAAG 
CAGAAATTAG AGCTGAAGAC AACCGAAGCA GGCCCAAGAT TGATGTCTGG AAAGCAGGCT 
GCAGCCATAA TCAAAGCAGT TGATTCAAAG TACACGGCCA TTCCCATTGT GGGGCAGGTC 
TTCCAGAGCC ACTGTAAAGG ATGTCCTTCT CTCTCGGAGC TCTGGCGGTC CACCAGGAAA 
TACCTGCAGC CTGACAACCT TTCCAAGGCT GAGGCTGTCA GAAACTTCCT GGCCTTCATT 
CAGCACCTCA GGACTGCGAA GAAAGAAGAG ATCCTTCAAA TACTAAAGAT GGAAAATAAG 
GAAGTATTAC CTCAGCTGGT GGATGCTGTC ACCTCTGCTC AGACCTCAGA CTCATTAGAA 
GCCATTTTGG ACTTTTTGGA TTTCAAAAGT GACAGCAGCA TTATCCTCCA GGAGAGGTTT 
CTCTATGCCT GTGGATTTGC TTCTCATCCC AATGAAGAAC TCCTGAGAGC CCTCATTAGT 
AAGTTCAAAG GTTCTATTGG TAGCAGTGAC ATCAGAGAAA CTGTTATGAT CATCACTGGG 
ACACTTGTCA GAAAGTTGTG TCAGAATGAA GGCTGCAAAC TCAAAGCAGT AGTGGAAGCT 
AAGAAGTTAA TCCTGGGAGG ACTTGAAAAA GCAGAGAAAA AAGAGGACAC CAGGATGTAT 
CTGCTGGCTT TGAAGAATGC CCTGCTTCCA GAAGGCATCC CAAGTCTTCT GAAGTATGCA 
GAAGCAGGAG AAGGGCCCAT CAGCCACCTG GCTACCACTG CTCTCCAGAG ATATGATCTC 
CCTTTCATAA CTGATGAGGT GAAGAAGACC TTAAACAGAA TATACCACCA AAACCGTAAA 
GTTCATGAAA AGACTGTGCG CACTGCTGCA GCTGCTATCA TTTTAAATAA CAATCCATCC 
TACATGGACG TCAAGAACAT CCTGCTGTCT ATTGGGGAGC TTCCCCAAGA AATGAATAAA 
TACATGCTCG CCATTGTTCA AGACATCCTA CGTTTTGAAA TGCCTGCAAG CAAAATTGTC 
CGTCGAGTTC TGAAGGAAAT GGTCGCTCAC AATTATGACC GTTTCTCCAG GAGTGGATCT 
TCTTCTGCCT ACACTGGCTA CATAGAACGT AGTCCCCGTT CGGCATCTAC TTACAGCCTA 
GACATTCTCT ACTCGGGTTC TGGCATTCTA AGGAGAAGTA ACCTGAACAT CTTTCAGTAC 
ATTGGGAAGG CTGGTCTTCA CGGTAGCCAG GTGGTTATTG AAGCCCAAGG ACTGGAAGCC 
TTAATCGCAG CCACCCCTGA CGAGGGGGAG GAGAACCTTG ACTCCTATGC TGGTATGTCA 
GCCATCCTCT TTGATGTTCA GCTCAGACCT GTCACCTTTT TCAACGGATA CAGTGATTTG 
ATGTCCAAAA TGCTGTCAGC ATCTGGCGAC CCTATCAGTG TGGTGAAAGG ACTTATTCTG 
CTAATAGATC ATTCTCAGGA ACTTCAGTTA CAATCTGGAC TAAAAGCCAA TATAGAGGTC 
CAGGGTGGTC TAGCTATTGA TATTTCAGGT GCAATGGAGT TTAGCTTGTG GTATCGTGAG 
TCTAAAACCC GAGTGAAAAA TAGGGTGACT GTGGTAATAA CCACTGACAT CACAGTGGAC 
TCCTCTTTTG TGAAAGCTGG CCTGGAAACC AGTACAGAAA CAGAAGCAGG CTTGGAGTTT 
ATCTCCACAG TGCAGTTTTC TCAGTACCCA TTCTTAGTTT GCATGCAGAT GGACAAGGAT 
GAAGCTCCAT TCAGGCAATT TGAGAAAAAG TACGAAAGGC TGTCCACAGG CAGAGGTTAT 
GTCTCTCAGA AAAGAAAAGA AAGCGTATTA GCAGGATGTG AATTCCCGCT CCATCAAGAG 
AACTCAGAGA TGTGCAAAGT GGTGTTTGCC CCTCAGCCGG ATAGTACTTC CAGCGGATGG 
TTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Association of MTTP gene variants with pediatric NAFLD: A candidate-gene-based analysis of single nucleotide variations in obese children.
PloS one12(9)e0185396(2017)
Dai D,Wen F,Zhou S,Su Z,Liu G,Wang M,Zhou J,He F

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MTTP cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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