MTCP1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	MTCP1
Entrez Gene ID	4515
Full Name	mature T cell proliferation 1
Synonyms	P13MTCP1,p8MTCP1
General protein information	Preferred Names mature T cell proliferation 1 Names protein p13 MTCP-1 MTCP-1 type B1 mature T-cell proliferation 1 isoform p13 mature T-cell proliferation-1 type B1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: X Map Location: Xq28
Summary	This gene was identified by involvement in some t(X;14) translocations associated with mature T-cell proliferations. This region has a complex gene structure, with a common promoter and 5' exon spliced to two different sets of 3' exons that encode two different proteins. This gene represents the upstream 13 kDa protein that is a member of the TCL1 family. This protein may be involved in leukemogenesis. [provided by RefSeq, Mar 2009].
Disorder MIM:	300116

mRNA and Protein(s)

mRNA	Protein	Name
NM_001018025.3	NP_001018025.1	protein p13 MTCP-1
NM_001018025.4	NP_001018025.1	protein p13 MTCP-1

Pathways from BioSystems

Homologies

Homo sapiens (human)	MTCP1	NP_001018025.1
Bos taurus (cattle)	CMC4	NP_001182552.1
Canis lupus familiaris (dog)	MTCP1	XP_549385.2
Pan troglodytes (chimpanzee)	MTCP1	XP_001144043.1
	MTCP1	XP_001098051.1

Gene Ontology
Bibliography

Related articles in PubMed

Polymorphisms in mitochondrial genes and prostate cancer risk.
Wang L, McDonnell SK, Hebbring SJ, Cunningham JM, St Sauver J, Cerhan JR, Isaya G, Schaid DJ, Thibodeau SN
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology17(12)3558-66(2008 Dec)

The MTCP1 oncogene modifies T-cell homeostasis before leukemogenesis in transgenic mice.
Joiner M, Le Toriellec E, Despouy G, Stern MH
Leukemia21(2)362-6(2007 Feb)

Differential regulation of Akt kinase isoforms by the members of the TCL1 oncogene family.
Laine J, K?nstle G, Obata T, Noguchi M
The Journal of biological chemistry277(5)3743-51(2002 Feb)

The protooncogene TCL1 is an Akt kinase coactivator.
Laine J, K?nstle G, Obata T, Sha M, Noguchi M
Molecular cell6(2)395-407(2000 Aug)

Backbone dynamics and solution structure refinement of the 15N-labeled human oncogenic protein p13MTCP1: comparison with X-ray data.
Guignard L, Padilla A, Mispelter J, Yang YS, Stern MH, Lhoste JM, Roumestand C
Journal of biomolecular NMR17(3)215-30(2000 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Observational study of gene-disease association. (HuGE Navigator)
Title: Polymorphisms in mitochondrial genes and prostate cancer risk.

Transgenic mice overexpressing MTCP1 develop leukemias with a CD8 central memory phenotype in most cases.
Title: The MTCP1 oncogene modifies T-cell homeostasis before leukemogenesis in transgenic mice.

The following MTCP1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MTCP1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu21063	NM_001018025.4 Latest version!	Homo sapiens mature T cell proliferation 1 (MTCP1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu21063	NM_001018025.3	Homo sapiens mature T cell proliferation 1 (MTCP1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

MTCP1 ( NM_001018025.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001018025.1 Homo sapiens mature T cell proliferation 1 (MTCP1), mRNA.

Price & Availability↑

CloneID	OHu21063
Clone ID Related Accession (Same CDS sequence)	NM_001018025.3 , NM_001018025.4
Accession Version	NM_001018025.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 324bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-12
Organism	Homo sapiens(human)
Product	protein p13 MTCP-1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BX470111.4, AW976554.1 and AA744518.1. This sequence is a reference standard in the RefSeqGene project. On Mar 24, 2009 this sequence version replaced NM_001018025.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BX341834.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968968 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCAGGAG AGGATGTGGG GGCTCCACCC GATCACCTCT GGGTTCACCA AGAGGGTATC 
TACCGCGACG AATACCAGCG CACGTGGGTG GCCGTCGTGG AAGAGGAGAC GAGTTTCCTA 
AGGGCACGAG TCCAGCAAAT TCAGGTTCCC TTAGGTGACG CAGCTAGGCC AAGTCACCTT 
CTTACCTCCC AGCTACCTCT CATGTGGCAA CTCTACCCGG AGGAGCGCTA CATGGATAAC 
AACTCTCGCT TGTGGCAGAT ACAGCATCAT TTAATGGTCA GGGGAGTACA GGAGCTGTTG 
CTTAAGCTTT TGCCTGATGA CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001018025.1
CDS	627..950
Translation	MAGEDVGAPPDHLWVHQEGIYRDEYQRTWVAVVEEETSFLRARVQQIQVPLGDAARPSHLLTSQLPLMWQLYPEERYMDNNSRLWQIQHHLMVRGVQELLLKLLPDD

Target ORF information:

RefSeq Version	NM_001018025.3
Organism	Homo sapiens(human)
Definition	Homo sapiens mature T cell proliferation 1 (MTCP1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001018025.3

ORF Insert Sequence:

ATGGCAGGAG AGGATGTGGG GGCTCCACCC GATCACCTCT GGGTTCACCA AGAGGGTATC 
TACCGCGACG AATACCAGCG CACGTGGGTG GCCGTCGTGG AAGAGGAGAC GAGTTTCCTA 
AGGGCACGAG TCCAGCAAAT TCAGGTTCCC TTAGGTGACG CAGCTAGGCC AAGTCACCTT 
CTTACCTCCC AGCTACCTCT CATGTGGCAA CTCTACCCGG AGGAGCGCTA CATGGATAAC 
AACTCTCGCT TGTGGCAGAT ACAGCATCAT TTAATGGTCA GGGGAGTACA GGAGCTGTTG 
CTTAAGCTTT TGCCTGATGA CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MTCP1 ( NM_001018025.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_001018025.1 Homo sapiens mature T cell proliferation 1 (MTCP1), mRNA.

Price & Availability↑

CloneID	OHu21063
Clone ID Related Accession (Same CDS sequence)	NM_001018025.3 , NM_001018025.4
Accession Version	NM_001018025.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 324bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-25
Organism	Homo sapiens(human)
Product	protein p13 MTCP-1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BX470111.4, AW976554.1 and AA744518.1. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_001018025.3. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BX341834.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968968 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta MANE Ensembl match :: ENST00000369476.8/ ENSP00000358488.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCAGGAG AGGATGTGGG GGCTCCACCC GATCACCTCT GGGTTCACCA AGAGGGTATC 
TACCGCGACG AATACCAGCG CACGTGGGTG GCCGTCGTGG AAGAGGAGAC GAGTTTCCTA 
AGGGCACGAG TCCAGCAAAT TCAGGTTCCC TTAGGTGACG CAGCTAGGCC AAGTCACCTT 
CTTACCTCCC AGCTACCTCT CATGTGGCAA CTCTACCCGG AGGAGCGCTA CATGGATAAC 
AACTCTCGCT TGTGGCAGAT ACAGCATCAT TTAATGGTCA GGGGAGTACA GGAGCTGTTG 
CTTAAGCTTT TGCCTGATGA CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001018025.1
CDS	491..814
Translation	MAGEDVGAPPDHLWVHQEGIYRDEYQRTWVAVVEEETSFLRARVQQIQVPLGDAARPSHLLTSQLPLMWQLYPEERYMDNNSRLWQIQHHLMVRGVQELLLKLLPDD

Target ORF information:

RefSeq Version	NM_001018025.4
Organism	Homo sapiens(human)
Definition	Homo sapiens mature T cell proliferation 1 (MTCP1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001018025.4

ORF Insert Sequence:

ATGGCAGGAG AGGATGTGGG GGCTCCACCC GATCACCTCT GGGTTCACCA AGAGGGTATC 
TACCGCGACG AATACCAGCG CACGTGGGTG GCCGTCGTGG AAGAGGAGAC GAGTTTCCTA 
AGGGCACGAG TCCAGCAAAT TCAGGTTCCC TTAGGTGACG CAGCTAGGCC AAGTCACCTT 
CTTACCTCCC AGCTACCTCT CATGTGGCAA CTCTACCCGG AGGAGCGCTA CATGGATAAC 
AACTCTCGCT TGTGGCAGAT ACAGCATCAT TTAATGGTCA GGGGAGTACA GGAGCTGTTG 
CTTAAGCTTT TGCCTGATGA CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Polymorphisms in mitochondrial genes and prostate cancer risk.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology17(12)3558-66(2008 Dec)
Wang L,McDonnell SK,Hebbring SJ,Cunningham JM,St Sauver J,Cerhan JR,Isaya G,Schaid DJ,Thibodeau SN

The MTCP1 oncogene modifies T-cell homeostasis before leukemogenesis in transgenic mice.
Leukemia21(2)362-6(2007 Feb)
Joiner M,Le Toriellec E,Despouy G,Stern MH

Differential regulation of Akt kinase isoforms by the members of the TCL1 oncogene family.
The Journal of biological chemistry277(5)3743-51(2002 Feb)
Laine J,K?nstle G,Obata T,Noguchi M

The protooncogene TCL1 is an Akt kinase coactivator.
Molecular cell6(2)395-407(2000 Aug)
Laine J,K?nstle G,Obata T,Sha M,Noguchi M

Backbone dynamics and solution structure refinement of the 15N-labeled human oncogenic protein p13MTCP1: comparison with X-ray data.
Journal of biomolecular NMR17(3)215-30(2000 Jul)
Guignard L,Padilla A,Mispelter J,Yang YS,Stern MH,Lhoste JM,Roumestand C

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MTCP1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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