MT2A cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	MT2A
Entrez Gene ID	4502
Full Name	metallothionein 2A
Synonyms	MT-2,MT-II,MT2
General protein information	Preferred Names metallothionein 2A Names metallothionein-2 metallothionein-II
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 16 Map Location: 16q13
Summary	This gene is a member of the metallothionein family of genes. Proteins encoded by this gene family are low in molecular weight, are cysteine-rich, lack aromatic residues, and bind divalent heavy metal ions, altering the intracellular concentration of heavy metals in the cell. These proteins act as anti-oxidants, protect against hydroxyl free radicals, are important in homeostatic control of metal in the cell, and play a role in detoxification of heavy metals. The encoded protein interacts with the protein encoded by the homeobox containing 1 gene in some cell types, controlling intracellular zinc levels, affecting apoptotic and autophagy pathways. Some polymorphisms in this gene are associated with an increased risk of cancer. [provided by RefSeq, Sep 2017].
Disorder MIM:	156360

mRNA and Protein(s)

mRNA	Protein	Name
NM_005953.3	NP_005944.1	metallothionein-2
NM_005953.5	NP_005944.1	metallothionein-2
NM_005953.4	NP_005944.1	metallothionein-2

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	MT2A	NP_001239523.1
Homo sapiens (human)	MT2A	NP_005944.1

Gene Ontology
Bibliography

Related articles in PubMed

Zinc binds non-cooperatively to human liver metallothionein 2a at physiological pH.
Jayawardena DP, Heinemann IU, Stillman MJ
Biochemical and biophysical research communications493(1)650-653(2017 11)

Metallothionein polymorphisms in a Northern Spanish population with neovascular and dry forms of age-related macular degeneration.
Garc?a M, ?lvarez L, Fern?ndez ?, Gonz?lez-Iglesias H, Escribano J, Fern?ndez-Vega B, Villota E, Fern?ndez-Vega Cueto L, Fern?ndez-Vega ?, Coca-Prados M
Ophthalmic genetics38(5)451-458(2017 Sep-Oct)

The Functions of Metallothionein and ZIP and ZnT Transporters: An Overview and Perspective.
Kimura T, Kambe T
International journal of molecular sciences17(3)336(2016 Mar)

Polymorphism of Metallothionein 2A Modifies Lead Body Burden in Workers Chronically Exposed to the Metal.
Fernandes KC, Martins AC Jr, Oliveira A?, Antunes LM, C?lus IM, Barbosa F Jr, Barcelos GR
Public health genomics19(1)47-52(2016)

HMBOX1 interacts with MT2A to regulate autophagy and apoptosis in vascular endothelial cells.
Ma H, Su L, Yue H, Yin X, Zhao J, Zhang S, Kung H, Xu Z, Miao J
Scientific reports515121(2015 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

the association of the blood lead level and HDL-C may be modified by the MT2A genetic combination
Title: The association of the blood lead level and serum lipid concentrations may be modified by the genetic combination of the metallothionein 2A polymorphisms rs10636?GC and rs28366003 AA.

The facility of forming bead-like structures at physiological pH for Zn5-MT2a means that Zn7-MT2a can donate up to two Zn(II) to Zn-dependent enzymes.
Title: Zinc binds non-cooperatively to human liver metallothionein 2a at physiological pH.

We found a significant association of SNP rs28366003 at MT2A gene with susceptibility to the dry form of AMD in a Northern Spanish population.
Title: Metallothionein polymorphisms in a Northern Spanish population with neovascular and dry forms of age-related macular degeneration.

Data suggest that genotype AA for SNP rs28366003 in MT2A is associated with higher blood zinc levels in subjects with diabetes type 2 (with chronic kidney disease) as compared to control subjects. This case-control, genetic association study was conducted in the Czech Republic.
Title: Levels of heavy metals and their binding protein metallothionein in type 2 diabetics with kidney disease.

Our results indicated that the rs10636 and rs28366003 polymorphisms in MT2A increased breast cancer risk in Northwest Chinese Han population.
Title: Genetic polymorphisms (rs10636 and rs28366003) in metallothionein 2A increase breast cancer risk in Chinese Han population.

The following MT2A gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MT2A cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu11076	NM_005953.5 Latest version!	Homo sapiens metallothionein 2A (MT2A), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu11076	NM_005953.3	Homo sapiens metallothionein 2A (MT2A), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu11076	NM_005953.4	Homo sapiens metallothionein 2A (MT2A), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

MT2A ( NM_005953.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_005944.1 Homo sapiens metallothionein 2A (MT2A), mRNA.

Price & Availability↑

CloneID	OHu11076
Clone ID Related Accession (Same CDS sequence)	NM_005953.3 , NM_005953.5 , NM_005953.4
Accession Version	NM_005953.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 186bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-09-08
Organism	Homo sapiens(Human)
Product	metallothionein-2
Comment	VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BM746626.1 and BC007034.1. On Sep 19, 2008 this sequence version replaced NM_005953.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC007034.1, CD177250.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END##

ATGGATCCCA ACTGCTCCTG CGCCGCCGGT GACTCCTGCA CCTGCGCCGG CTCCTGCAAA 
TGCAAAGAGT GCAAATGCAC CTCCTGCAAG AAAAGCTGCT GCTCCTGCTG CCCTGTGGGC 
TGTGCCAAGT GTGCCCAGGG CTGCATCTGC AAAGGGGCGT CGGACAAGTG CAGCTGCTGC 
GCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005944.1
CDS	91..276
Translation	MDPNCSCAAGDSCTCAGSCKCKECKCTSCKKSCCSCCPVGCAKCAQGCICKGASDKCSCCA

Target ORF information:

RefSeq Version	NM_005953.3
Organism	Homo sapiens(Human)
Definition	Homo sapiens metallothionein 2A (MT2A), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005953.3

ORF Insert Sequence:

ATGGATCCCA ACTGCTCCTG CGCCGCCGGT GACTCCTGCA CCTGCGCCGG CTCCTGCAAA 
TGCAAAGAGT GCAAATGCAC CTCCTGCAAG AAAAGCTGCT GCTCCTGCTG CCCTGTGGGC 
TGTGCCAAGT GTGCCCAGGG CTGCATCTGC AAAGGGGCGT CGGACAAGTG CAGCTGCTGC 
GCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MT2A ( NM_005953.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_005944.1 Homo sapiens metallothionein 2A (MT2A), mRNA.

Price & Availability↑

CloneID	OHu11076
Clone ID Related Accession (Same CDS sequence)	NM_005953.3 , NM_005953.5 , NM_005953.4
Accession Version	NM_005953.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 186bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-21
Organism	Homo sapiens(human)
Product	metallothionein-2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC007034.1. On Nov 23, 2018 this sequence version replaced NM_005953.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BM739923.1, BM817906.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000245185.6/ ENSP00000245185.5 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGATCCCA ACTGCTCCTG CGCCGCCGGT GACTCCTGCA CCTGCGCCGG CTCCTGCAAA 
TGCAAAGAGT GCAAATGCAC CTCCTGCAAG AAAAGCTGCT GCTCCTGCTG CCCTGTGGGC 
TGTGCCAAGT GTGCCCAGGG CTGCATCTGC AAAGGGGCGT CGGACAAGTG CAGCTGCTGC 
GCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005944.1
CDS	73..258
Translation	MDPNCSCAAGDSCTCAGSCKCKECKCTSCKKSCCSCCPVGCAKCAQGCICKGASDKCSCCA

Target ORF information:

RefSeq Version	NM_005953.5
Organism	Homo sapiens(human)
Definition	Homo sapiens metallothionein 2A (MT2A), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005953.5

ORF Insert Sequence:

ATGGATCCCA ACTGCTCCTG CGCCGCCGGT GACTCCTGCA CCTGCGCCGG CTCCTGCAAA 
TGCAAAGAGT GCAAATGCAC CTCCTGCAAG AAAAGCTGCT GCTCCTGCTG CCCTGTGGGC 
TGTGCCAAGT GTGCCCAGGG CTGCATCTGC AAAGGGGCGT CGGACAAGTG CAGCTGCTGC 
GCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MT2A ( NM_005953.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_005944.1 Homo sapiens metallothionein 2A (MT2A), mRNA.

Price & Availability↑

CloneID	OHu11076
Clone ID Related Accession (Same CDS sequence)	NM_005953.3 , NM_005953.5 , NM_005953.4
Accession Version	NM_005953.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 186bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-05
Organism	Homo sapiens(human)
Product	metallothionein-2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DW466290.1 and BC007034.1. On Sep 5, 2017 this sequence version replaced NM_005953.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BI600241.1, ERR279849.7859.1 [ECO:0000332] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGATCCCA ACTGCTCCTG CGCCGCCGGT GACTCCTGCA CCTGCGCCGG CTCCTGCAAA 
TGCAAAGAGT GCAAATGCAC CTCCTGCAAG AAAAGCTGCT GCTCCTGCTG CCCTGTGGGC 
TGTGCCAAGT GTGCCCAGGG CTGCATCTGC AAAGGGGCGT CGGACAAGTG CAGCTGCTGC 
GCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005944.1
CDS	124..309
Translation	MDPNCSCAAGDSCTCAGSCKCKECKCTSCKKSCCSCCPVGCAKCAQGCICKGASDKCSCCA

Target ORF information:

RefSeq Version	NM_005953.4
Organism	Homo sapiens(human)
Definition	Homo sapiens metallothionein 2A (MT2A), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005953.4

ORF Insert Sequence:

ATGGATCCCA ACTGCTCCTG CGCCGCCGGT GACTCCTGCA CCTGCGCCGG CTCCTGCAAA 
TGCAAAGAGT GCAAATGCAC CTCCTGCAAG AAAAGCTGCT GCTCCTGCTG CCCTGTGGGC 
TGTGCCAAGT GTGCCCAGGG CTGCATCTGC AAAGGGGCGT CGGACAAGTG CAGCTGCTGC 
GCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Zinc binds non-cooperatively to human liver metallothionein 2a at physiological pH.
Biochemical and biophysical research communications493(1)650-653(2017 11)
Jayawardena DP,Heinemann IU,Stillman MJ

Metallothionein polymorphisms in a Northern Spanish population with neovascular and dry forms of age-related macular degeneration.
Ophthalmic genetics38(5)451-458(2017 Sep-Oct)
Garc?a M,?lvarez L,Fern?ndez ?,Gonz?lez-Iglesias H,Escribano J,Fern?ndez-Vega B,Villota E,Fern?ndez-Vega Cueto L,Fern?ndez-Vega ?,Coca-Prados M

The Functions of Metallothionein and ZIP and ZnT Transporters: An Overview and Perspective.
International journal of molecular sciences17(3)336(2016 Mar)
Kimura T,Kambe T

Polymorphism of Metallothionein 2A Modifies Lead Body Burden in Workers Chronically Exposed to the Metal.
Public health genomics19(1)47-52(2016)
Fernandes KC,Martins AC Jr,Oliveira A?,Antunes LM,C?lus IM,Barbosa F Jr,Barcelos GR

HMBOX1 interacts with MT2A to regulate autophagy and apoptosis in vascular endothelial cells.
Scientific reports515121(2015 Oct)
Ma H,Su L,Yue H,Yin X,Zhao J,Zhang S,Kung H,Xu Z,Miao J

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MT2A cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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