MT1X cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	MT1X
Entrez Gene ID	4501
Full Name	metallothionein 1X
Synonyms	MT-1l,MT1
General protein information	Preferred Names metallothionein 1X Names metallothionein-1X MT-1X MT-IX metallothionein-IX testicular tissue protein Li 124
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 16 Map Location: 16q13
Disorder MIM:	156359

mRNA and Protein(s)

mRNA	Protein	Name
NM_005952.3	NP_005943.1	metallothionein-1X
NM_005952.4	NP_005943.1	metallothionein-1X

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	MT1X	XP_003339330.1
Homo sapiens (human)	MT1X	NP_005943.1

Gene Ontology
Bibliography

Related articles in PubMed

Expression of Metallothionein and Vascular Endothelial Growth Factor Isoforms in Breast Cancer Cells.
Wierzowiecka B, Gomulkiewicz A, Cwynar-Zajac L, Olbromski M, Grzegrzolka J, Kobierzycki C, Podhorska-Okolow M, Dziegiel P
In vivo (Athens, Greece)30(3)271-8(2016 May-Jun)

Evaluation of MT1XT20 Single Quasi-Monomorphic Mononucleotide Marker for Characterizing Microsatellite Instability in Persian Lynch Syndrome Patients.
Farahani N, Nikpou P, Emami MH, Hashemzadeh M, Zeinalian M, Shariatpanahi SS, Salehi R
Asian Pacific journal of cancer prevention : APJCP17(9)4259-4265(2016)

Identification and characterization of MT-1X as a novel FHL3-binding partner.
Cai X, Wang J, Huang X, Fu W, Xia W, Zou M, Wang Y, Wang J, Xu D
PloS one9(4)e93723(2014)

Microarray-assisted pathway analysis identifies MT1X & NF?B as mediators of TCRP1-associated resistance to cisplatin in oral squamous cell carcinoma.
Peng B, Gu Y, Xiong Y, Zheng G, He Z
PloS one7(12)e51413(2012)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data show that in the MCF-7 breast cancer cell line, only MT1X metallothioneins (MTs) positively correlated with vascular endothelial growth factor C (VEGFC).
Title: Expression of Metallothionein and Vascular Endothelial Growth Factor Isoforms in Breast Cancer Cells.

MT1XT20 Single Quasi-Monomorphic Mononucleotide Marker showing Microsatellite Instability is associated with Persian Lynch Syndrome
Title: Evaluation of MT1XT20 Single Quasi-Monomorphic Mononucleotide Marker for Characterizing Microsatellite Instability in Persian Lynch Syndrome Patients.

These findings suggest that functional interactions between FHL3 and MT-1X may provide some clues to the mechanisms of FHL3-regulated cell proliferation.
Title: Identification and characterization of MT-1X as a novel FHL3-binding partner.

Results show variation in MTX1 is implicated in disordered gambling
Title: Genome-wide association study of a quantitative disordered gambling trait.

siRNA-mediated knockdown of TCRP1 and MT1X was found to sensitize cells to cisplatin, leading to increased apoptosis and inhibition of cell proliferation
Title: Microarray-assisted pathway analysis identifies MT1X & NF?B as mediators of TCRP1-associated resistance to cisplatin in oral squamous cell carcinoma.

The following MT1X gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MT1X cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu24826	NM_005952.4 Latest version!	Homo sapiens metallothionein 1X (MT1X), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu24826	NM_005952.3	Homo sapiens metallothionein 1X (MT1X), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

MT1X ( NM_005952.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_005943.1 Homo sapiens metallothionein 1X (MT1X), mRNA.

Price & Availability↑

CloneID	OHu24826
Clone ID Related Accession (Same CDS sequence)	NM_005952.3 , NM_005952.4
Accession Version	NM_005952.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 186bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-26
Organism	Homo sapiens(human)
Product	metallothionein-1X
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CD101947.1 and BC032338.1. On Jul 12, 2008 this sequence version replaced NM_005952.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: HM005437.1, BF185660.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END##

ATGGACCCCA ACTGCTCCTG CTCGCCTGTT GGCTCCTGTG CCTGTGCCGG CTCCTGCAAA 
TGCAAAGAGT GCAAATGCAC CTCCTGCAAG AAGAGCTGCT GCTCCTGCTG CCCTGTGGGC 
TGTGCCAAGT GTGCCCAGGG CTGCATCTGC AAAGGGACGT CAGACAAGTG CAGCTGCTGT 
GCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005943.1
CDS	72..257
Translation	MDPNCSCSPVGSCACAGSCKCKECKCTSCKKSCCSCCPVGCAKCAQGCICKGTSDKCSCCA

Target ORF information:

RefSeq Version	NM_005952.3
Organism	Homo sapiens(human)
Definition	Homo sapiens metallothionein 1X (MT1X), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005952.3

ORF Insert Sequence:

ATGGACCCCA ACTGCTCCTG CTCGCCTGTT GGCTCCTGTG CCTGTGCCGG CTCCTGCAAA 
TGCAAAGAGT GCAAATGCAC CTCCTGCAAG AAGAGCTGCT GCTCCTGCTG CCCTGTGGGC 
TGTGCCAAGT GTGCCCAGGG CTGCATCTGC AAAGGGACGT CAGACAAGTG CAGCTGCTGT 
GCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MT1X ( NM_005952.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_005943.1 Homo sapiens metallothionein 1X (MT1X), mRNA.

Price & Availability↑

CloneID	OHu24826
Clone ID Related Accession (Same CDS sequence)	NM_005952.3 , NM_005952.4
Accession Version	NM_005952.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 186bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	metallothionein-1X
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CD101947.1 and BC032338.1. On Nov 22, 2018 this sequence version replaced NM_005952.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: HM005437.1, CD101947.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000394485.5/ ENSP00000377995.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGACCCCA ACTGCTCCTG CTCGCCTGTT GGCTCCTGTG CCTGTGCCGG CTCCTGCAAA 
TGCAAAGAGT GCAAATGCAC CTCCTGCAAG AAGAGCTGCT GCTCCTGCTG CCCTGTGGGC 
TGTGCCAAGT GTGCCCAGGG CTGCATCTGC AAAGGGACGT CAGACAAGTG CAGCTGCTGT 
GCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005943.1
CDS	72..257
Translation	MDPNCSCSPVGSCACAGSCKCKECKCTSCKKSCCSCCPVGCAKCAQGCICKGTSDKCSCCA

Target ORF information:

RefSeq Version	NM_005952.4
Organism	Homo sapiens(human)
Definition	Homo sapiens metallothionein 1X (MT1X), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005952.4

ORF Insert Sequence:

ATGGACCCCA ACTGCTCCTG CTCGCCTGTT GGCTCCTGTG CCTGTGCCGG CTCCTGCAAA 
TGCAAAGAGT GCAAATGCAC CTCCTGCAAG AAGAGCTGCT GCTCCTGCTG CCCTGTGGGC 
TGTGCCAAGT GTGCCCAGGG CTGCATCTGC AAAGGGACGT CAGACAAGTG CAGCTGCTGT 
GCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Expression of Metallothionein and Vascular Endothelial Growth Factor Isoforms in Breast Cancer Cells.
In vivo (Athens, Greece)30(3)271-8(2016 May-Jun)
Wierzowiecka B,Gomulkiewicz A,Cwynar-Zajac L,Olbromski M,Grzegrzolka J,Kobierzycki C,Podhorska-Okolow M,Dziegiel P

Evaluation of MT1XT20 Single Quasi-Monomorphic Mononucleotide Marker for Characterizing Microsatellite Instability in Persian Lynch Syndrome Patients.
Asian Pacific journal of cancer prevention : APJCP17(9)4259-4265(2016)
Farahani N,Nikpou P,Emami MH,Hashemzadeh M,Zeinalian M,Shariatpanahi SS,Salehi R

Identification and characterization of MT-1X as a novel FHL3-binding partner.
PloS one9(4)e93723(2014)
Cai X,Wang J,Huang X,Fu W,Xia W,Zou M,Wang Y,Wang J,Xu D

Microarray-assisted pathway analysis identifies MT1X & NF?B as mediators of TCRP1-associated resistance to cisplatin in oral squamous cell carcinoma.
PloS one7(12)e51413(2012)
Peng B,Gu Y,Xiong Y,Zheng G,He Z

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MT1X cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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