MT1A cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	MT1A
Entrez Gene ID	4489
Full Name	metallothionein 1A
Synonyms	MT-1A,MT-IA,MT1,MT1S,MTC
General protein information	Preferred Names metallothionein 1A Names metallothionein-1A metallothionein 1A (functional) metallothionein 1S metallothionein-IA
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 16 Map Location: 16q13
Summary	This gene is a member of the metallothionein family of genes. Proteins encoded by this gene family are low in molecular weight, are cysteine-rich, lack aromatic residues, and bind divalent heavy metal ions. The conserved cysteine residues co-ordinate metal ions using mercaptide linkages. These proteins act as anti-oxidants, protect against hydroxyl free radicals, are important in homeostatic control of metal in the cell, and play a role in detoxification of heavy metals. Disruption of two metallothionein genes in mouse resulted in defects in protection against heavy metals, oxidative stress, immune reactions, carcinogens, and displayed obesity. [provided by RefSeq, Sep 2017].
Disorder MIM:	156350

mRNA and Protein(s)

mRNA	Protein	Name
NM_005946.2	NP_005937.2	metallothionein-1A
NM_005946.3	NP_005937.2	metallothionein-1A

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

Selective cysteine modification of metal-free human metallothionein 1a and its isolated domain fragments: Solution structural properties revealed via ESI-MS.
Irvine GW, Santolini M, Stillman MJ
Protein science : a publication of the Protein Society26(5)960-971(2017 May)

Blockade of Metallothioneins 1 and 2 Increases Skeletal Muscle Mass and Strength.
Summermatter S, Bouzan A, Pierrel E, Melly S, Stauffer D, Gutzwiller S, Nolin E, Dornelas C, Fryer C, Leighton-Davies J, Glass DJ, Fournier B
Molecular and cellular biology37(5)(2017 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Selective cysteine modification of metal-free human metallothionein 1a and its isolated domain fragments: Solution structural properties revealed via ESI-MS.
Title: Selective cysteine modification of metal-free human metallothionein 1a and its isolated domain fragments: Solution structural properties revealed via ESI-MS.

blockade of metallothioneins 1 and 2 constitutes a promising approach for the treatment of conditions which result in muscle atrophy.
Title: Blockade of Metallothioneins 1 and 2 Increases Skeletal Muscle Mass and Strength.

The present study was undertaken to explore further the interrelationship between p53 and metallothioneins.
Title: Basal and copper-induced expression of metallothionein isoform 1,2 and 3 genes in epithelial cancer cells: The role of tumor suppressor p53.

Neonatal phthalate ester exposure induced placental MTs, FATP1 and HFABP mRNA expression
Title: Neonatal phthalate ester exposure induced placental MTs, FATP1 and HFABP mRNA expression in two districts of southeast China.

These results clearly suggest that MT-1 may be involved in AD pathogenesis.
Title: Overexpression of Metallothionein-1 Modulates the Phenotype of the Tg2576 Mouse Model of Alzheimer's Disease.

The following MT1A gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MT1A cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu29185	NM_005946.3 Latest version!	Homo sapiens metallothionein 1A (MT1A), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu29185	NM_005946.2	Homo sapiens metallothionein 1A (MT1A), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

MT1A ( NM_005946.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_005937.2 Homo sapiens metallothionein 1A (MT1A), mRNA.

Price & Availability↑

CloneID	OHu29185
Clone ID Related Accession (Same CDS sequence)	NM_005946.2 , NM_005946.3
Accession Version	NM_005946.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 186bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-26
Organism	Homo sapiens(human)
Product	metallothionein-1A
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AY028617.1 and BC029475.1. On Jul 27, 2005 this sequence version replaced NM_005946.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY028617.1, BM694421.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGACCCCA ACTGCTCCTG CGCCACTGGT GGCTCCTGCA CCTGCACTGG CTCCTGCAAA 
TGCAAAGAGT GCAAATGCAC CTCCTGCAAG AAGAGCTGCT GCTCCTGCTG CCCCATGAGC 
TGTGCCAAGT GTGCCCAGGG CTGCATCTGC AAAGGGGCAT CAGAGAAGTG CAGCTGCTGT 
GCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005937.2
CDS	74..259
Translation	MDPNCSCATGGSCTCTGSCKCKECKCTSCKKSCCSCCPMSCAKCAQGCICKGASEKCSCCA

Target ORF information:

RefSeq Version	NM_005946.2
Organism	Homo sapiens(human)
Definition	Homo sapiens metallothionein 1A (MT1A), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005946.2

ORF Insert Sequence:

ATGGACCCCA ACTGCTCCTG CGCCACTGGT GGCTCCTGCA CCTGCACTGG CTCCTGCAAA 
TGCAAAGAGT GCAAATGCAC CTCCTGCAAG AAGAGCTGCT GCTCCTGCTG CCCCATGAGC 
TGTGCCAAGT GTGCCCAGGG CTGCATCTGC AAAGGGGCAT CAGAGAAGTG CAGCTGCTGT 
GCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MT1A ( NM_005946.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_005937.2 Homo sapiens metallothionein 1A (MT1A), mRNA.

Price & Availability↑

CloneID	OHu29185
Clone ID Related Accession (Same CDS sequence)	NM_005946.2 , NM_005946.3
Accession Version	NM_005946.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 186bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	metallothionein-1A
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AY028617.1 and BC029475.1. On Nov 23, 2018 this sequence version replaced NM_005946.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY028617.1, BJ995397.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000290705.12/ ENSP00000290705.8 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGACCCCA ACTGCTCCTG CGCCACTGGT GGCTCCTGCA CCTGCACTGG CTCCTGCAAA 
TGCAAAGAGT GCAAATGCAC CTCCTGCAAG AAGAGCTGCT GCTCCTGCTG CCCCATGAGC 
TGTGCCAAGT GTGCCCAGGG CTGCATCTGC AAAGGGGCAT CAGAGAAGTG CAGCTGCTGT 
GCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005937.2
CDS	74..259
Translation	MDPNCSCATGGSCTCTGSCKCKECKCTSCKKSCCSCCPMSCAKCAQGCICKGASEKCSCCA

Target ORF information:

RefSeq Version	NM_005946.3
Organism	Homo sapiens(human)
Definition	Homo sapiens metallothionein 1A (MT1A), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005946.3

ORF Insert Sequence:

ATGGACCCCA ACTGCTCCTG CGCCACTGGT GGCTCCTGCA CCTGCACTGG CTCCTGCAAA 
TGCAAAGAGT GCAAATGCAC CTCCTGCAAG AAGAGCTGCT GCTCCTGCTG CCCCATGAGC 
TGTGCCAAGT GTGCCCAGGG CTGCATCTGC AAAGGGGCAT CAGAGAAGTG CAGCTGCTGT 
GCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Selective cysteine modification of metal-free human metallothionein 1a and its isolated domain fragments: Solution structural properties revealed via ESI-MS.
Protein science : a publication of the Protein Society26(5)960-971(2017 May)
Irvine GW,Santolini M,Stillman MJ

Blockade of Metallothioneins 1 and 2 Increases Skeletal Muscle Mass and Strength.
Molecular and cellular biology37(5)(2017 Mar)
Summermatter S,Bouzan A,Pierrel E,Melly S,Stauffer D,Gutzwiller S,Nolin E,Dornelas C,Fryer C,Leighton-Davies J,Glass DJ,Fournier B

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MT1A cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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