MSH5 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	MSH5
Entrez Gene ID	4439
Full Name	mutS homolog 5
Synonyms	G7,MUTSH5,NG23,POF13
General protein information	Preferred Names mutS homolog 5 Names mutS protein homolog 5
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 6 Map Location: 6p21.33
Summary	This gene encodes a member of the mutS family of proteins that are involved in DNA mismatch repair and meiotic recombination. This protein is similar to a Saccharomyces cerevisiae protein that participates in segregation fidelity and crossing-over events during meiosis. This protein plays a role in promoting ionizing radiation-induced apoptosis. This protein forms hetero-oligomers with another member of this family, mutS homolog 4. Polymorphisms in this gene have been linked to various human diseases, including IgA deficiency, common variable immunodeficiency, and premature ovarian failure. Alternative splicing results multiple transcript variants. Read-through transcription also exists between this gene and the downstream chromosome 6 open reading frame 26 (C6orf26) gene. [provided by RefSeq, Feb 2011].
Disorder MIM:	603382
Disorder Html:	?Premature ovarian failure 13, 617442 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_172165.3	NP_751897.1	mutS protein homolog 5 isoform b
NM_025259.5	NP_079535.4	mutS protein homolog 5 isoform a
NM_002441.4	NP_002432.1	mutS protein homolog 5 isoform c
NM_172166.3	NP_751898.1	mutS protein homolog 5 isoform c
NM_172166.4	NP_751898.1	mutS protein homolog 5 isoform c

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	MSH5	XP_001158290.1
Rattus norvegicus (Norway rat)	Msh5	NP_997701.2
Canis lupus familiaris (dog)	MSH5	XP_005627803.1
Bos taurus (cattle)	MSH5	NP_001192428.1
Caenorhabditis elegans (roundworm)	msh-5	NP_502531.1
Kluyveromyces lactis	KLLA0C16423g	XP_452934.1
Magnaporthe oryzae (rice blast fungus)	MGG_05639	XP_003710529.1
Xenopus tropicalis (tropical clawed frog)	msh5	XP_002939511.2
Danio rerio (zebrafish)	msh5	XP_005157849.1
Saccharomyces cerevisiae (baker's yeast)	MSH5	NP_010127.1
Oryza sativa (rice)	Os05g0498300	NP_001055948.1
Homo sapiens (human)	MSH5	NP_751897.1
	MSH5	XP_001105745.1
Mus musculus (house mouse)	Msh5	NP_038628.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP002642	XP_312286.5
Neurospora crassa	NCU09384	XP_963830.1
Arabidopsis thaliana (thale cress)	MSH5	NP_188683.3

Gene Ontology
Bibliography

Related articles in PubMed

Mutations in MSH5 in primary ovarian insufficiency.
Guo T, Zhao S, Zhao S, Chen M, Li G, Jiao X, Wang Z, Zhao Y, Qin Y, Gao F, Chen ZJ
Human molecular genetics26(8)1452-1457(2017 04)

Association between DNA mismatch repair gene polymorphisms and platinum-based chemotherapy toxicity in non-small cell lung cancer patients.
Liu JY, Qian CY, Gao YF, Chen J, Zhou HH, Yin JY
Chinese journal of cancer36(1)12(2017 Jan)

hMSH4-hMSH5 adenosine nucleotide processing and interactions with homologous recombination machinery.
Snowden T, Shim KS, Schmutte C, Acharya S, Fishel R
The Journal of biological chemistry283(1)145-54(2008 Jan)

Role for Msh5 in the regulation of Ig class switch recombination.
Sekine H, Ferreira RC, Pan-Hammarstr?m Q, Graham RR, Ziemba B, de Vries SS, Liu J, Hippen K, Koeuth T, Ortmann W, Iwahori A, Elliott MK, Offer S, Skon C, Du L, Novitzke J, Lee AT, Zhao N, Tompkins JD, Altshuler D, Gregersen PK, Cunningham-Rundles C, Harris RS, Her C, Nelson DL, Hammarstr?m L, Gilkeson GS, Behrens TW
Proceedings of the National Academy of Sciences of the United States of America104(17)7193-8(2007 Apr)

Two variants of MutS homolog hMSH5: prevalence in humans and effects on protein interaction.
Yi W, Wu X, Lee TH, Doggett NA, Her C
Biochemical and biophysical research communications332(2)524-32(2005 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

From sanger sequencing of MSH5 in 200 sporadic POI patients, we identified three heterozygous mutations . Considering the heterozygous p.D487Y carrier in the POI pedigree was fertile, the causality of the three heterozygous mutations in POI need more evidence
Title: Mutations in MSH5 in primary ovarian insufficiency.

Findings indicate that carriers of the MSH5 rs707939 T allele, the MSH2 rs6544991 C allele, the MSH3 rs6151627 and rs6151670 G alleles, and the MSH3 rs7709909 T allele have poor toxicity tolerance to platinum-based chemotherapy in non-small cell lung cancer patients.
Title: Association between DNA mismatch repair gene polymorphisms and platinum-based chemotherapy toxicity in non-small cell lung cancer patients.

our data point to the existence of a functional interplay between hMSH5 and FANCJ in double-strand break repair induced by replication stress.
Title: hMSH5 Facilitates the Repair of Camptothecin-induced Double-strand Breaks through an Interaction with FANCJ.

the roles of hMSH5 variants in the processes of DNA damage response and repair
Title: MutS homologue hMSH5: recombinational DSB repair and non-synonymous polymorphic variants.

Authors show that MSH5 (MutSHomolog 5) is localized into the mitochondria of germ and somatic cells.
Title: The human MSH5 (MutSHomolog 5) protein localizes to mitochondria and protects the mitochondrial genome from oxidative damage.

The following MSH5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MSH5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu22913	NM_172165.3 Latest version!	Homo sapiens mutS homolog 5 (MSH5), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu15927	NM_025259.5 Latest version!	Homo sapiens mutS homolog 5 (MSH5), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$391.30 $559.00
OHu15753	NM_002441.4 Latest version!	Homo sapiens mutS homolog 5 (MSH5), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$69.30 $99.00
OHu15753	NM_172166.4 Latest version!	Homo sapiens mutS homolog 5 (MSH5), transcript variant 4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$475.30 $679.00
View Old Accession Versions >>
OHu15753	NM_172166.3	Homo sapiens mutS homolog 5 (MSH5), transcript variant 4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$69.30 $99.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

MSH5 ( NM_172165.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_751897.1 Homo sapiens mutS homolog 5 (MSH5), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu22913
Clone ID Related Accession (Same CDS sequence)	NM_172165.3
Accession Version	NM_172165.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2508bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-06-07
Organism	Homo sapiens(human)
Product	mutS protein homolog 5 isoform b
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL662899.5, DB448226.1, BC001358.2 and BF116106.1. On Oct 30, 2009 this sequence version replaced NM_172165.2. Transcript Variant: This variant (2) uses alternate in-frame splice sites in both the central and 3' coding regions, compared to variant 1, resulting in an isoform (b) that is longer than isoform a. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC001358.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCCTCCT TAGGAGCGAA CCCAAGGAGG ACACCGCAGG GACCGAGACC TGGGGCGGCC 
TCCTCCGGCT TCCCCAGCCC GGCCCCAGTG CCGGGCCCCA GGGAGGCCGA GGAGGAGGAA 
GTCGAGGAGG AGGAGGAGCT GGCCGAGATC CATCTGTGTG TGCTGTGGAA TTCAGGATAC 
TTGGGCATTG CCTACTATGA TACTAGTGAC TCCACTATCC ACTTCATGCC AGATGCCCCA 
GACCACGAGA GCCTCAAGCT TCTCCAGAGA GTTCTGGATG AGATCAATCC CCAGTCTGTT 
GTTACGAGTG CCAAACAGGA TGAGAATATG ACTCGATTTC TGGGAAAGCT TGCCTCCCAG 
GAGCACAGAG AGCCTAAAAG ACCTGAAATC ATATTTTTGC CAAGTGTGGA TTTTGGTCTG 
GAGATAAGCA AACAACGCCT CCTTTCTGGA AACTACTCCT TCATCCCAGA CGCCATGACT 
GCCACTGAGA AAATCCTCTT CCTCTCTTCC ATTATTCCCT TTGACTGCCT CCTCACAGTT 
CGAGCACTTG GAGGGCTGCT GAAGTTCCTG GGTCGAAGAA GAATCGGGGT TGAACTGGAA 
GACTATAATG TCAGCGTCCC CATCCTGGGC TTTAAGAAAT TTATGTTGAC TCATCTGGTG 
AACATAGATC AAGACACTTA CAGTGTTCTA CAGATTTTTA AGAGTGAGTC TCACCCCTCA 
GTGTACAAAG TGGCCAGTGG ACTGAAGGAG GGGCTCAGCC TCTTTGGAAT CCTCAACAGA 
TGCCACTGTA AGTGGGGAGA GAAGCTGCTC AGGCTATGGT TCACACGTCC GACTCATGAC 
CTGGGGGAGC TCAGTTCTCG TCTGGACGTC ATTCAGTTTT TTCTGCTGCC CCAGAATCTG 
GACATGGCTC AGATGCTGCA TCGGCTCCTG GGTCACATCA AGAACGTGCC TCTGATTCTG 
AAACGCATGA AGTTGTCCCA CACCAAGGTC AGCGACTGGC AGGTTCTCTA CAAGACTGTG 
TACAGTGCCC TGGGCCTGAG GGATGCCTGC CGCTCCCTGC CGCAGTCCAT CCAGCTCTTT 
CGGGACATTG CCCAAGAGTT CTCTGATGAC CTGCACCATA TCGCCAGCCT CATTGGGAAA 
GTAGTGGACT TTGAGGGCAG CCTTGCTGAA AATCGCTTCA CAGTCCTCCC CAACATAGAT 
CCTGAAATTG ATGAGAAAAA GCGAAGACTG ATGGGACTTC CCAGTTTCCT TACTGAGGTT 
GCCCGCAAGG AGCTGGAGAA TCTGGACTCC CGTATTCCTT CATGCAGTGT CATCTACATC 
CCTCTGATTG GCTTCCTTCT TTCTATTCCC CGCCTGCCTT CCATGGTAGA GGCCAGTGAC 
TTTGAGATTA ATGGACTGGA CTTCATGTTT CTCTCAGAGG AGAAGCTGCA CTATCGTAGT 
GCCCGAACCA AGGAGCTGGA TGCATTGCTG GGGGACCTGC ACTGCGAGAT CCGGGACCAG 
GAGACGCTGC TGATGTACCA GCTACAGTGC CAGGTGCTGG CACGAGCAGC TGTCTTAACC 
CGAGTATTGG ACCTTGCCTC CCGCCTGGAC GTCCTGCTGG CTCTTGCCAG TGCTGCCCGG 
GACTATGGCT ACTCAAGGCC GCGTTACTCC CCACAAGTCC TTGGGGTACG AATCCAGAAT 
GGCAGACATC CTCTGATGGA ACTCTGTGCC CGAACCTTTG TGCCCAACTC CACAGAATGT 
GGTGGGGACA AAGGGAGGGT CAAAGTCATC ACTGGACCCA ACTCATCAGG GAAGAGCATA 
TACCTCAAAC AGGTAGGCTT GATCACATTC ATGGCCCTGG TAGGCAGCTT TGTGCCAGCA 
GAGGAGGCCG AAATTGGGGC AGTAGACGCC ATCTTCACAC GAATTCATAG CTGCGAATCC 
ATCTCCCTTG GCCTCTCCAC CTTCATGATC GACCTCAACC AGCAGGTGGC GAAAGCAGTG 
AACAATGCCA CTGCACAGTC GCTGGTCCTT ATTGATGAAT TTGGAAAGGG AACCAACACG 
GTGGATGGGC TCGCGCTTCT GGCCGCTGTG CTCCGACACT GGCTGGCACG TGGACCCACA 
TGCCCCCACA TCTTTGTGGC CACCAACTTT CTGAGCCTTG TTCAGCTACA ACTGCTGCCA 
CAAGGGCCCC TGGTGCAGTA TTTGACCATG GAGACCTGTG AGGATGGCAA CGATCTTGTC 
TTCTTCTATC AGGTTTGCGA AGGTGTTGCG AAGGCCAGCC ATGCCTCCCA CACAGCTGCC 
CAGGCTGGGC TTCCTGACAA GCTTGTGGCT CGTGGCAAGG AGGTCTCAGA CTTGATCCGC 
AGTGGAAAAC CCATCAAGCC TGTCAAGGAT TTGCTAAAGA AGAACCAAAT GGAAAATTGC 
CAGACATTAG TGGATAAGTT TATGAAACTG GATTTGGAAG ATCCTAACCT GGACTTGAAC 
GTTTTCATGA GCCAGGAAGT GCTGCCTGCT GCCACCAGCA TCCTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_751897.1
CDS	129..2636
Translation	MASLGANPRRTPQGPRPGAASSGFPSPAPVPGPREAEEEEVEEEEELAEIHLCVLWNSGYLGIAYYDTSDSTIHFMPDAPDHESLKLLQRVLDEINPQSVVTSAKQDENMTRFLGKLASQEHREPKRPEIIFLPSVDFGLEISKQRLLSGNYSFIPDAMTATEKILFLSSIIPFDCLLTVRALGGLLKFLGRRRIGVELEDYNVSVPILGFKKFMLTHLVNIDQDTYSVLQIFKSESHPSVYKVASGLKEGLSLFGILNRCHCKWGEKLLRLWFTRPTHDLGELSSRLDVIQFFLLPQNLDMAQMLHRLLGHIKNVPLILKRMKLSHTKVSDWQVLYKTVYSALGLRDACRSLPQSIQLFRDIAQEFSDDLHHIASLIGKVVDFEGSLAENRFTVLPNIDPEIDEKKRRLMGLPSFLTEVARKELENLDSRIPSCSVIYIPLIGFLLSIPRLPSMVEASDFEINGLDFMFLSEEKLHYRSARTKELDALLGDLHCEIRDQETLLMYQLQCQVLARAAVLTRVLDLASRLDVLLALASAARDYGYSRPRYSPQVLGVRIQNGRHPLMELCARTFVPNSTECGGDKGRVKVITGPNSSGKSIYLKQVGLITFMALVGSFVPAEEAEIGAVDAIFTRIHSCESISLGLSTFMIDLNQQVAKAVNNATAQSLVLIDEFGKGTNTVDGLALLAAVLRHWLARGPTCPHIFVATNFLSLVQLQLLPQGPLVQYLTMETCEDGNDLVFFYQVCEGVAKASHASHTAAQAGLPDKLVARGKEVSDLIRSGKPIKPVKDLLKKNQMENCQTLVDKFMKLDLEDPNLDLNVFMSQEVLPAATSIL

Target ORF information:

RefSeq Version	NM_172165.3
Organism	Homo sapiens(human)
Definition	Homo sapiens mutS homolog 5 (MSH5), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_172165.3

ORF Insert Sequence:

ATGGCCTCCT TAGGAGCGAA CCCAAGGAGG ACACCGCAGG GACCGAGACC TGGGGCGGCC 
TCCTCCGGCT TCCCCAGCCC GGCCCCAGTG CCGGGCCCCA GGGAGGCCGA GGAGGAGGAA 
GTCGAGGAGG AGGAGGAGCT GGCCGAGATC CATCTGTGTG TGCTGTGGAA TTCAGGATAC 
TTGGGCATTG CCTACTATGA TACTAGTGAC TCCACTATCC ACTTCATGCC AGATGCCCCA 
GACCACGAGA GCCTCAAGCT TCTCCAGAGA GTTCTGGATG AGATCAATCC CCAGTCTGTT 
GTTACGAGTG CCAAACAGGA TGAGAATATG ACTCGATTTC TGGGAAAGCT TGCCTCCCAG 
GAGCACAGAG AGCCTAAAAG ACCTGAAATC ATATTTTTGC CAAGTGTGGA TTTTGGTCTG 
GAGATAAGCA AACAACGCCT CCTTTCTGGA AACTACTCCT TCATCCCAGA CGCCATGACT 
GCCACTGAGA AAATCCTCTT CCTCTCTTCC ATTATTCCCT TTGACTGCCT CCTCACAGTT 
CGAGCACTTG GAGGGCTGCT GAAGTTCCTG GGTCGAAGAA GAATCGGGGT TGAACTGGAA 
GACTATAATG TCAGCGTCCC CATCCTGGGC TTTAAGAAAT TTATGTTGAC TCATCTGGTG 
AACATAGATC AAGACACTTA CAGTGTTCTA CAGATTTTTA AGAGTGAGTC TCACCCCTCA 
GTGTACAAAG TGGCCAGTGG ACTGAAGGAG GGGCTCAGCC TCTTTGGAAT CCTCAACAGA 
TGCCACTGTA AGTGGGGAGA GAAGCTGCTC AGGCTATGGT TCACACGTCC GACTCATGAC 
CTGGGGGAGC TCAGTTCTCG TCTGGACGTC ATTCAGTTTT TTCTGCTGCC CCAGAATCTG 
GACATGGCTC AGATGCTGCA TCGGCTCCTG GGTCACATCA AGAACGTGCC TCTGATTCTG 
AAACGCATGA AGTTGTCCCA CACCAAGGTC AGCGACTGGC AGGTTCTCTA CAAGACTGTG 
TACAGTGCCC TGGGCCTGAG GGATGCCTGC CGCTCCCTGC CGCAGTCCAT CCAGCTCTTT 
CGGGACATTG CCCAAGAGTT CTCTGATGAC CTGCACCATA TCGCCAGCCT CATTGGGAAA 
GTAGTGGACT TTGAGGGCAG CCTTGCTGAA AATCGCTTCA CAGTCCTCCC CAACATAGAT 
CCTGAAATTG ATGAGAAAAA GCGAAGACTG ATGGGACTTC CCAGTTTCCT TACTGAGGTT 
GCCCGCAAGG AGCTGGAGAA TCTGGACTCC CGTATTCCTT CATGCAGTGT CATCTACATC 
CCTCTGATTG GCTTCCTTCT TTCTATTCCC CGCCTGCCTT CCATGGTAGA GGCCAGTGAC 
TTTGAGATTA ATGGACTGGA CTTCATGTTT CTCTCAGAGG AGAAGCTGCA CTATCGTAGT 
GCCCGAACCA AGGAGCTGGA TGCATTGCTG GGGGACCTGC ACTGCGAGAT CCGGGACCAG 
GAGACGCTGC TGATGTACCA GCTACAGTGC CAGGTGCTGG CACGAGCAGC TGTCTTAACC 
CGAGTATTGG ACCTTGCCTC CCGCCTGGAC GTCCTGCTGG CTCTTGCCAG TGCTGCCCGG 
GACTATGGCT ACTCAAGGCC GCGTTACTCC CCACAAGTCC TTGGGGTACG AATCCAGAAT 
GGCAGACATC CTCTGATGGA ACTCTGTGCC CGAACCTTTG TGCCCAACTC CACAGAATGT 
GGTGGGGACA AAGGGAGGGT CAAAGTCATC ACTGGACCCA ACTCATCAGG GAAGAGCATA 
TACCTCAAAC AGGTAGGCTT GATCACATTC ATGGCCCTGG TAGGCAGCTT TGTGCCAGCA 
GAGGAGGCCG AAATTGGGGC AGTAGACGCC ATCTTCACAC GAATTCATAG CTGCGAATCC 
ATCTCCCTTG GCCTCTCCAC CTTCATGATC GACCTCAACC AGCAGGTGGC GAAAGCAGTG 
AACAATGCCA CTGCACAGTC GCTGGTCCTT ATTGATGAAT TTGGAAAGGG AACCAACACG 
GTGGATGGGC TCGCGCTTCT GGCCGCTGTG CTCCGACACT GGCTGGCACG TGGACCCACA 
TGCCCCCACA TCTTTGTGGC CACCAACTTT CTGAGCCTTG TTCAGCTACA ACTGCTGCCA 
CAAGGGCCCC TGGTGCAGTA TTTGACCATG GAGACCTGTG AGGATGGCAA CGATCTTGTC 
TTCTTCTATC AGGTTTGCGA AGGTGTTGCG AAGGCCAGCC ATGCCTCCCA CACAGCTGCC 
CAGGCTGGGC TTCCTGACAA GCTTGTGGCT CGTGGCAAGG AGGTCTCAGA CTTGATCCGC 
AGTGGAAAAC CCATCAAGCC TGTCAAGGAT TTGCTAAAGA AGAACCAAAT GGAAAATTGC 
CAGACATTAG TGGATAAGTT TATGAAACTG GATTTGGAAG ATCCTAACCT GGACTTGAAC 
GTTTTCATGA GCCAGGAAGT GCTGCCTGCT GCCACCAGCA TCCTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MSH5 ( NM_025259.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_079535.4 Homo sapiens mutS homolog 5 (MSH5), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu15927
Clone ID Related Accession (Same CDS sequence)	NM_025259.5
Accession Version	NM_025259.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2469bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-06-23
Organism	Homo sapiens(human)
Product	mutS protein homolog 5 isoform a
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL662899.5, DB448226.1, BC041031.1 and BF116106.1. On Oct 30, 2009 this sequence version replaced NM_025259.4. Transcript Variant: This variant (1) represents the shortest transcript and encodes the shortest isoform (a). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC041031.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2148093 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCCTCCT TAGGAGCGAA CCCAAGGAGG ACACCGCAGG GACCGAGACC TGGGGCGGCC 
TCCTCCGGCT TCCCCAGCCC GGCCCCAGTG CCGGGCCCCA GGGAGGCCGA GGAGGAGGAA 
GTCGAGGAGG AGGAGGAGCT GGCCGAGATC CATCTGTGTG TGCTGTGGAA TTCAGGATAC 
TTGGGCATTG CCTACTATGA TACTAGTGAC TCCACTATCC ACTTCATGCC AGATGCCCCA 
GACCACGAGA GCCTCAAGCT TCTCCAGAGA GTTCTGGATG AGATCAATCC CCAGTCTGTT 
GTTACGAGTG CCAAACAGGA TGAGAATATG ACTCGATTTC TGGGAAAGCT TGCCTCCCAG 
GAGCACAGAG AGCCTAAAAG ACCTGAAATC ATATTTTTGC CAAGTGTGGA TTTTGGTCTG 
GAGATAAGCA AACAACGCCT CCTTTCTGGA AACTACTCCT TCATCCCAGA CGCCATGACT 
GCCACTGAGA AAATCCTCTT CCTCTCTTCC ATTATTCCCT TTGACTGCCT CCTCACACCC 
CCAGGAGATT TAAGATTTAC CCCGATTCCA CTGCTGATCC CCTCCCAGGT TCGAGCACTT 
GGAGGGCTGC TGAAGTTCCT GGGTCGAAGA AGAATCGGGG TTGAACTGGA AGACTATAAT 
GTCAGCGTCC CCATCCTGGG CTTTAAGAAA TTTATGTTGA CTCATCTGGT GAACATAGAT 
CAAGACACTT ACAGTGTTCT ACAGATTTTT AAGAGTGAGT CTCACCCCTC AGTGTACAAA 
GTGGCCAGTG GACTGAAGGA GGGGCTCAGC CTCTTTGGAA TCCTCAACAG ATGCCACTGT 
AAGTGGGGAG AGAAGCTGCT CAGGCTATGG TTCACACGTC CGACTCATGA CCTGGGGGAG 
CTCAGTTCTC GTCTGGACGT CATTCAGTTT TTTCTGCTGC CCCAGAATCT GGACATGGCT 
CAGATGCTGC ATCGGCTCCT GGGTCACATC AAGAACGTGC CTCTGATTCT GAAACGCATG 
AAGTTGTCCC ACACCAAGGT CAGCGACTGG CAGGTTCTCT ACAAGACTGT GTACAGTGCC 
CTGGGCCTGA GGGATGCCTG CCGCTCCCTG CCGCAGTCCA TCCAGCTCTT TCGGGACATT 
GCCCAAGAGT TCTCTGATGA CCTGCACCAT ATCGCCAGCC TCATTGGGAA AGTAGTGGAC 
TTTGAGGGCA GCCTTGCTGA AAATCGCTTC ACAGTCCTCC CCAACATAGA TCCTGAAATT 
GATGAGAAAA AGCGAAGACT GATGGGACTT CCCAGTTTCC TTACTGAGGT TGCCCGCAAG 
GAGCTGGAGA ATCTGGACTC CCGTATTCCT TCATGCAGTG TCATCTACAT CCCTCTGATT 
GGCTTCCTTC TTTCTATTCC CCGCCTGCCT TCCATGGTAG AGGCCAGTGA CTTTGAGATT 
AATGGACTGG ACTTCATGTT TCTCTCAGAG GAGAAGCTGC ACTATCGTAG TGCCCGAACC 
AAGGAGCTGG ATGCATTGCT GGGGGACCTG CACTGCGAGA TCCGGGACCA GGAGACGCTG 
CTGATGTACC AGCTACAGTG CCAGGTGCTG GCACGAGCAG CTGTCTTAAC CCGAGTATTG 
GACCTTGCCT CCCGCCTGGA CGTCCTGCTG GCTCTTGCCA GTGCTGCCCG GGACTATGGC 
TACTCAAGGC CGCGTTACTC CCCACAAGTC CTTGGGGTAC GAATCCAGAA TGGCAGACAT 
CCTCTGATGG AACTCTGTGC CCGAACCTTT GTGCCCAACT CCACAGAATG TGGTGGGGAC 
AAAGGGAGGG TCAAAGTCAT CACTGGACCC AACTCATCAG GGAAGAGCAT ATACCTCAAA 
CAGGTAGGCT TGATCACATT CATGGCCCTG GTAGGCAGCT TTGTGCCAGC AGAGGAGGCC 
GAAATTGGGG CAGTAGACGC CATCTTCACA CGAATTCATA GCTGCGAATC CATCTCCCTT 
GGCCTCTCCA CCTTCATGAT CGACCTCAAC CAGCAGGTGG CGAAAGCAGT GAACAATGCC 
ACTGCACAGT CGCTGGTCCT TATTGATGAA TTTGGAAAGG GAACCAACAC GGTGGATGGG 
CTCGCGCTTC TGGCCGCTGT GCTCCGACAC TGGCTGGCAC GTGGACCCAC ATGCCCCCAC 
ATCTTTGTGG CCACCAACTT TCTGAGCCTT GTTCAGCTAC AACTGCTGCC ACAAGGGCCC 
CTGGTGCAGT ATTTGACCAT GGAGACCTGT GAGGATGGCA ACGATCTTGT CTTCTTCTAT 
CAGGTCTCAG ACTTGATCCG CAGTGGAAAA CCCATCAAGC CTGTCAAGGA TTTGCTAAAG 
AAGAACCAAA TGGAAAATTG CCAGACATTA GTGGATAAGT TTATGAAACT GGATTTGGAA 
GATCCTAACC TGGACTTGAA CGTTTTCATG AGCCAGGAAG TGCTGCCTGC TGCCACCAGC 
ATCCTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_079535.4
CDS	129..2597
Translation	MASLGANPRRTPQGPRPGAASSGFPSPAPVPGPREAEEEEVEEEEELAEIHLCVLWNSGYLGIAYYDTSDSTIHFMPDAPDHESLKLLQRVLDEINPQSVVTSAKQDENMTRFLGKLASQEHREPKRPEIIFLPSVDFGLEISKQRLLSGNYSFIPDAMTATEKILFLSSIIPFDCLLTPPGDLRFTPIPLLIPSQVRALGGLLKFLGRRRIGVELEDYNVSVPILGFKKFMLTHLVNIDQDTYSVLQIFKSESHPSVYKVASGLKEGLSLFGILNRCHCKWGEKLLRLWFTRPTHDLGELSSRLDVIQFFLLPQNLDMAQMLHRLLGHIKNVPLILKRMKLSHTKVSDWQVLYKTVYSALGLRDACRSLPQSIQLFRDIAQEFSDDLHHIASLIGKVVDFEGSLAENRFTVLPNIDPEIDEKKRRLMGLPSFLTEVARKELENLDSRIPSCSVIYIPLIGFLLSIPRLPSMVEASDFEINGLDFMFLSEEKLHYRSARTKELDALLGDLHCEIRDQETLLMYQLQCQVLARAAVLTRVLDLASRLDVLLALASAARDYGYSRPRYSPQVLGVRIQNGRHPLMELCARTFVPNSTECGGDKGRVKVITGPNSSGKSIYLKQVGLITFMALVGSFVPAEEAEIGAVDAIFTRIHSCESISLGLSTFMIDLNQQVAKAVNNATAQSLVLIDEFGKGTNTVDGLALLAAVLRHWLARGPTCPHIFVATNFLSLVQLQLLPQGPLVQYLTMETCEDGNDLVFFYQVSDLIRSGKPIKPVKDLLKKNQMENCQTLVDKFMKLDLEDPNLDLNVFMSQEVLPAATSIL

Target ORF information:

RefSeq Version	NM_025259.5
Organism	Homo sapiens(human)
Definition	Homo sapiens mutS homolog 5 (MSH5), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_025259.5

ORF Insert Sequence:

ATGGCCTCCT TAGGAGCGAA CCCAAGGAGG ACACCGCAGG GACCGAGACC TGGGGCGGCC 
TCCTCCGGCT TCCCCAGCCC GGCCCCAGTG CCGGGCCCCA GGGAGGCCGA GGAGGAGGAA 
GTCGAGGAGG AGGAGGAGCT GGCCGAGATC CATCTGTGTG TGCTGTGGAA TTCAGGATAC 
TTGGGCATTG CCTACTATGA TACTAGTGAC TCCACTATCC ACTTCATGCC AGATGCCCCA 
GACCACGAGA GCCTCAAGCT TCTCCAGAGA GTTCTGGATG AGATCAATCC CCAGTCTGTT 
GTTACGAGTG CCAAACAGGA TGAGAATATG ACTCGATTTC TGGGAAAGCT TGCCTCCCAG 
GAGCACAGAG AGCCTAAAAG ACCTGAAATC ATATTTTTGC CAAGTGTGGA TTTTGGTCTG 
GAGATAAGCA AACAACGCCT CCTTTCTGGA AACTACTCCT TCATCCCAGA CGCCATGACT 
GCCACTGAGA AAATCCTCTT CCTCTCTTCC ATTATTCCCT TTGACTGCCT CCTCACACCC 
CCAGGAGATT TAAGATTTAC CCCGATTCCA CTGCTGATCC CCTCCCAGGT TCGAGCACTT 
GGAGGGCTGC TGAAGTTCCT GGGTCGAAGA AGAATCGGGG TTGAACTGGA AGACTATAAT 
GTCAGCGTCC CCATCCTGGG CTTTAAGAAA TTTATGTTGA CTCATCTGGT GAACATAGAT 
CAAGACACTT ACAGTGTTCT ACAGATTTTT AAGAGTGAGT CTCACCCCTC AGTGTACAAA 
GTGGCCAGTG GACTGAAGGA GGGGCTCAGC CTCTTTGGAA TCCTCAACAG ATGCCACTGT 
AAGTGGGGAG AGAAGCTGCT CAGGCTATGG TTCACACGTC CGACTCATGA CCTGGGGGAG 
CTCAGTTCTC GTCTGGACGT CATTCAGTTT TTTCTGCTGC CCCAGAATCT GGACATGGCT 
CAGATGCTGC ATCGGCTCCT GGGTCACATC AAGAACGTGC CTCTGATTCT GAAACGCATG 
AAGTTGTCCC ACACCAAGGT CAGCGACTGG CAGGTTCTCT ACAAGACTGT GTACAGTGCC 
CTGGGCCTGA GGGATGCCTG CCGCTCCCTG CCGCAGTCCA TCCAGCTCTT TCGGGACATT 
GCCCAAGAGT TCTCTGATGA CCTGCACCAT ATCGCCAGCC TCATTGGGAA AGTAGTGGAC 
TTTGAGGGCA GCCTTGCTGA AAATCGCTTC ACAGTCCTCC CCAACATAGA TCCTGAAATT 
GATGAGAAAA AGCGAAGACT GATGGGACTT CCCAGTTTCC TTACTGAGGT TGCCCGCAAG 
GAGCTGGAGA ATCTGGACTC CCGTATTCCT TCATGCAGTG TCATCTACAT CCCTCTGATT 
GGCTTCCTTC TTTCTATTCC CCGCCTGCCT TCCATGGTAG AGGCCAGTGA CTTTGAGATT 
AATGGACTGG ACTTCATGTT TCTCTCAGAG GAGAAGCTGC ACTATCGTAG TGCCCGAACC 
AAGGAGCTGG ATGCATTGCT GGGGGACCTG CACTGCGAGA TCCGGGACCA GGAGACGCTG 
CTGATGTACC AGCTACAGTG CCAGGTGCTG GCACGAGCAG CTGTCTTAAC CCGAGTATTG 
GACCTTGCCT CCCGCCTGGA CGTCCTGCTG GCTCTTGCCA GTGCTGCCCG GGACTATGGC 
TACTCAAGGC CGCGTTACTC CCCACAAGTC CTTGGGGTAC GAATCCAGAA TGGCAGACAT 
CCTCTGATGG AACTCTGTGC CCGAACCTTT GTGCCCAACT CCACAGAATG TGGTGGGGAC 
AAAGGGAGGG TCAAAGTCAT CACTGGACCC AACTCATCAG GGAAGAGCAT ATACCTCAAA 
CAGGTAGGCT TGATCACATT CATGGCCCTG GTAGGCAGCT TTGTGCCAGC AGAGGAGGCC 
GAAATTGGGG CAGTAGACGC CATCTTCACA CGAATTCATA GCTGCGAATC CATCTCCCTT 
GGCCTCTCCA CCTTCATGAT CGACCTCAAC CAGCAGGTGG CGAAAGCAGT GAACAATGCC 
ACTGCACAGT CGCTGGTCCT TATTGATGAA TTTGGAAAGG GAACCAACAC GGTGGATGGG 
CTCGCGCTTC TGGCCGCTGT GCTCCGACAC TGGCTGGCAC GTGGACCCAC ATGCCCCCAC 
ATCTTTGTGG CCACCAACTT TCTGAGCCTT GTTCAGCTAC AACTGCTGCC ACAAGGGCCC 
CTGGTGCAGT ATTTGACCAT GGAGACCTGT GAGGATGGCA ACGATCTTGT CTTCTTCTAT 
CAGGTCTCAG ACTTGATCCG CAGTGGAAAA CCCATCAAGC CTGTCAAGGA TTTGCTAAAG 
AAGAACCAAA TGGAAAATTG CCAGACATTA GTGGATAAGT TTATGAAACT GGATTTGGAA 
GATCCTAACC TGGACTTGAA CGTTTTCATG AGCCAGGAAG TGCTGCCTGC TGCCACCAGC 
ATCCTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MSH5 ( NM_002441.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_002432.1 Homo sapiens mutS homolog 5 (MSH5), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu15753
Clone ID Related Accession (Same CDS sequence)	NM_002441.4 , NM_172166.3 , NM_172166.4
Accession Version	NM_002441.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2505bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Homo sapiens(human)
Product	mutS protein homolog 5 isoform c
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL662899.5, DB448226.1, AF048986.1 and BF116106.1. On Oct 30, 2009 this sequence version replaced NM_002441.3. Transcript Variant: This variant (3) differs in the 5' UTR and uses alternate in-frame splice sites in both the central and 3' coding regions, compared to variant 1, resulting in an isoform (c) that is longer than isoform a. Both variants 3 and 4 encode the same isoform. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF070071.1, AF048986.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1968968 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCCTCCT TAGGAGCGAA CCCAAGGAGG ACACCGCAGG GACCGAGACC TGGGGCGGCC 
TCCTCCGGCT TCCCCAGCCC GGCCCCAGTG CCGGGCCCCA GGGAGGCCGA GGAGGAGGAA 
GTCGAGGAGG AGGAGGAGCT GGCCGAGATC CATCTGTGTG TGCTGTGGAA TTCAGGATAC 
TTGGGCATTG CCTACTATGA TACTAGTGAC TCCACTATCC ACTTCATGCC AGATGCCCCA 
GACCACGAGA GCCTCAAGCT TCTCCAGAGA GTTCTGGATG AGATCAATCC CCAGTCTGTT 
GTTACGAGTG CCAAACAGGA TGAGAATATG ACTCGATTTC TGGGAAAGCT TGCCTCCCAG 
GAGCACAGAG AGCCTAAAAG ACCTGAAATC ATATTTTTGC CAAGTGTGGA TTTTGGTCTG 
GAGATAAGCA AACAACGCCT CCTTTCTGGA AACTACTCCT TCATCCCAGA CGCCATGACT 
GCCACTGAGA AAATCCTCTT CCTCTCTTCC ATTATTCCCT TTGACTGCCT CCTCACAGTT 
CGAGCACTTG GAGGGCTGCT GAAGTTCCTG GGTCGAAGAA GAATCGGGGT TGAACTGGAA 
GACTATAATG TCAGCGTCCC CATCCTGGGC TTTAAGAAAT TTATGTTGAC TCATCTGGTG 
AACATAGATC AAGACACTTA CAGTGTTCTA CAGATTTTTA AGAGTGAGTC TCACCCCTCA 
GTGTACAAAG TGGCCAGTGG ACTGAAGGAG GGGCTCAGCC TCTTTGGAAT CCTCAACAGA 
TGCCACTGTA AGTGGGGAGA GAAGCTGCTC AGGCTATGGT TCACACGTCC GACTCATGAC 
CTGGGGGAGC TCAGTTCTCG TCTGGACGTC ATTCAGTTTT TTCTGCTGCC CCAGAATCTG 
GACATGGCTC AGATGCTGCA TCGGCTCCTG GGTCACATCA AGAACGTGCC TCTGATTCTG 
AAACGCATGA AGTTGTCCCA CACCAAGGTC AGCGACTGGC AGGTTCTCTA CAAGACTGTG 
TACAGTGCCC TGGGCCTGAG GGATGCCTGC CGCTCCCTGC CGCAGTCCAT CCAGCTCTTT 
CGGGACATTG CCCAAGAGTT CTCTGATGAC CTGCACCATA TCGCCAGCCT CATTGGGAAA 
GTAGTGGACT TTGAGGGCAG CCTTGCTGAA AATCGCTTCA CAGTCCTCCC CAACATAGAT 
CCTGAAATTG ATGAGAAAAA GCGAAGACTG ATGGGACTTC CCAGTTTCCT TACTGAGGTT 
GCCCGCAAGG AGCTGGAGAA TCTGGACTCC CGTATTCCTT CATGCAGTGT CATCTACATC 
CCTCTGATTG GCTTCCTTCT TTCTATTCCC CGCCTGCCTT CCATGGTAGA GGCCAGTGAC 
TTTGAGATTA ATGGACTGGA CTTCATGTTT CTCTCAGAGG AGAAGCTGCA CTATCGTAGT 
GCCCGAACCA AGGAGCTGGA TGCATTGCTG GGGGACCTGC ACTGCGAGAT CCGGGACCAG 
GAGACGCTGC TGATGTACCA GCTACAGTGC CAGGTGCTGG CACGAGCAGC TGTCTTAACC 
CGAGTATTGG ACCTTGCCTC CCGCCTGGAC GTCCTGCTGG CTCTTGCCAG TGCTGCCCGG 
GACTATGGCT ACTCAAGGCC GCGTTACTCC CCACAAGTCC TTGGGGTACG AATCCAGAAT 
GGCAGACATC CTCTGATGGA ACTCTGTGCC CGAACCTTTG TGCCCAACTC CACAGAATGT 
GGTGGGGACA AAGGGAGGGT CAAAGTCATC ACTGGACCCA ACTCATCAGG GAAGAGCATA 
TACCTCAAAC AGGTAGGCTT GATCACATTC ATGGCCCTGG TAGGCAGCTT TGTGCCAGCA 
GAGGAGGCCG AAATTGGGGC AGTAGACGCC ATCTTCACAC GAATTCATAG CTGCGAATCC 
ATCTCCCTTG GCCTCTCCAC CTTCATGATC GACCTCAACC AGGTGGCGAA AGCAGTGAAC 
AATGCCACTG CACAGTCGCT GGTCCTTATT GATGAATTTG GAAAGGGAAC CAACACGGTG 
GATGGGCTCG CGCTTCTGGC CGCTGTGCTC CGACACTGGC TGGCACGTGG ACCCACATGC 
CCCCACATCT TTGTGGCCAC CAACTTTCTG AGCCTTGTTC AGCTACAACT GCTGCCACAA 
GGGCCCCTGG TGCAGTATTT GACCATGGAG ACCTGTGAGG ATGGCAACGA TCTTGTCTTC 
TTCTATCAGG TTTGCGAAGG TGTTGCGAAG GCCAGCCATG CCTCCCACAC AGCTGCCCAG 
GCTGGGCTTC CTGACAAGCT TGTGGCTCGT GGCAAGGAGG TCTCAGACTT GATCCGCAGT 
GGAAAACCCA TCAAGCCTGT CAAGGATTTG CTAAAGAAGA ACCAAATGGA AAATTGCCAG 
ACATTAGTGG ATAAGTTTAT GAAACTGGAT TTGGAAGATC CTAACCTGGA CTTGAACGTT 
TTCATGAGCC AGGAAGTGCT GCCTGCTGCC ACCAGCATCC TCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002432.1
CDS	287..2791
Translation	MASLGANPRRTPQGPRPGAASSGFPSPAPVPGPREAEEEEVEEEEELAEIHLCVLWNSGYLGIAYYDTSDSTIHFMPDAPDHESLKLLQRVLDEINPQSVVTSAKQDENMTRFLGKLASQEHREPKRPEIIFLPSVDFGLEISKQRLLSGNYSFIPDAMTATEKILFLSSIIPFDCLLTVRALGGLLKFLGRRRIGVELEDYNVSVPILGFKKFMLTHLVNIDQDTYSVLQIFKSESHPSVYKVASGLKEGLSLFGILNRCHCKWGEKLLRLWFTRPTHDLGELSSRLDVIQFFLLPQNLDMAQMLHRLLGHIKNVPLILKRMKLSHTKVSDWQVLYKTVYSALGLRDACRSLPQSIQLFRDIAQEFSDDLHHIASLIGKVVDFEGSLAENRFTVLPNIDPEIDEKKRRLMGLPSFLTEVARKELENLDSRIPSCSVIYIPLIGFLLSIPRLPSMVEASDFEINGLDFMFLSEEKLHYRSARTKELDALLGDLHCEIRDQETLLMYQLQCQVLARAAVLTRVLDLASRLDVLLALASAARDYGYSRPRYSPQVLGVRIQNGRHPLMELCARTFVPNSTECGGDKGRVKVITGPNSSGKSIYLKQVGLITFMALVGSFVPAEEAEIGAVDAIFTRIHSCESISLGLSTFMIDLNQVAKAVNNATAQSLVLIDEFGKGTNTVDGLALLAAVLRHWLARGPTCPHIFVATNFLSLVQLQLLPQGPLVQYLTMETCEDGNDLVFFYQVCEGVAKASHASHTAAQAGLPDKLVARGKEVSDLIRSGKPIKPVKDLLKKNQMENCQTLVDKFMKLDLEDPNLDLNVFMSQEVLPAATSIL

Target ORF information:

RefSeq Version	NM_002441.4
Organism	Homo sapiens(human)
Definition	Homo sapiens mutS homolog 5 (MSH5), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002441.4

ORF Insert Sequence:

ATGGCCTCCT TAGGAGCGAA CCCAAGGAGG ACACCGCAGG GACCGAGACC TGGGGCGGCC 
TCCTCCGGCT TCCCCAGCCC GGCCCCAGTG CCGGGCCCCA GGGAGGCCGA GGAGGAGGAA 
GTCGAGGAGG AGGAGGAGCT GGCCGAGATC CATCTGTGTG TGCTGTGGAA TTCAGGATAC 
TTGGGCATTG CCTACTATGA TACTAGTGAC TCCACTATCC ACTTCATGCC AGATGCCCCA 
GACCACGAGA GCCTCAAGCT TCTCCAGAGA GTTCTGGATG AGATCAATCC CCAGTCTGTT 
GTTACGAGTG CCAAACAGGA TGAGAATATG ACTCGATTTC TGGGAAAGCT TGCCTCCCAG 
GAGCACAGAG AGCCTAAAAG ACCTGAAATC ATATTTTTGC CAAGTGTGGA TTTTGGTCTG 
GAGATAAGCA AACAACGCCT CCTTTCTGGA AACTACTCCT TCATCCCAGA CGCCATGACT 
GCCACTGAGA AAATCCTCTT CCTCTCTTCC ATTATTCCCT TTGACTGCCT CCTCACAGTT 
CGAGCACTTG GAGGGCTGCT GAAGTTCCTG GGTCGAAGAA GAATCGGGGT TGAACTGGAA 
GACTATAATG TCAGCGTCCC CATCCTGGGC TTTAAGAAAT TTATGTTGAC TCATCTGGTG 
AACATAGATC AAGACACTTA CAGTGTTCTA CAGATTTTTA AGAGTGAGTC TCACCCCTCA 
GTGTACAAAG TGGCCAGTGG ACTGAAGGAG GGGCTCAGCC TCTTTGGAAT CCTCAACAGA 
TGCCACTGTA AGTGGGGAGA GAAGCTGCTC AGGCTATGGT TCACACGTCC GACTCATGAC 
CTGGGGGAGC TCAGTTCTCG TCTGGACGTC ATTCAGTTTT TTCTGCTGCC CCAGAATCTG 
GACATGGCTC AGATGCTGCA TCGGCTCCTG GGTCACATCA AGAACGTGCC TCTGATTCTG 
AAACGCATGA AGTTGTCCCA CACCAAGGTC AGCGACTGGC AGGTTCTCTA CAAGACTGTG 
TACAGTGCCC TGGGCCTGAG GGATGCCTGC CGCTCCCTGC CGCAGTCCAT CCAGCTCTTT 
CGGGACATTG CCCAAGAGTT CTCTGATGAC CTGCACCATA TCGCCAGCCT CATTGGGAAA 
GTAGTGGACT TTGAGGGCAG CCTTGCTGAA AATCGCTTCA CAGTCCTCCC CAACATAGAT 
CCTGAAATTG ATGAGAAAAA GCGAAGACTG ATGGGACTTC CCAGTTTCCT TACTGAGGTT 
GCCCGCAAGG AGCTGGAGAA TCTGGACTCC CGTATTCCTT CATGCAGTGT CATCTACATC 
CCTCTGATTG GCTTCCTTCT TTCTATTCCC CGCCTGCCTT CCATGGTAGA GGCCAGTGAC 
TTTGAGATTA ATGGACTGGA CTTCATGTTT CTCTCAGAGG AGAAGCTGCA CTATCGTAGT 
GCCCGAACCA AGGAGCTGGA TGCATTGCTG GGGGACCTGC ACTGCGAGAT CCGGGACCAG 
GAGACGCTGC TGATGTACCA GCTACAGTGC CAGGTGCTGG CACGAGCAGC TGTCTTAACC 
CGAGTATTGG ACCTTGCCTC CCGCCTGGAC GTCCTGCTGG CTCTTGCCAG TGCTGCCCGG 
GACTATGGCT ACTCAAGGCC GCGTTACTCC CCACAAGTCC TTGGGGTACG AATCCAGAAT 
GGCAGACATC CTCTGATGGA ACTCTGTGCC CGAACCTTTG TGCCCAACTC CACAGAATGT 
GGTGGGGACA AAGGGAGGGT CAAAGTCATC ACTGGACCCA ACTCATCAGG GAAGAGCATA 
TACCTCAAAC AGGTAGGCTT GATCACATTC ATGGCCCTGG TAGGCAGCTT TGTGCCAGCA 
GAGGAGGCCG AAATTGGGGC AGTAGACGCC ATCTTCACAC GAATTCATAG CTGCGAATCC 
ATCTCCCTTG GCCTCTCCAC CTTCATGATC GACCTCAACC AGGTGGCGAA AGCAGTGAAC 
AATGCCACTG CACAGTCGCT GGTCCTTATT GATGAATTTG GAAAGGGAAC CAACACGGTG 
GATGGGCTCG CGCTTCTGGC CGCTGTGCTC CGACACTGGC TGGCACGTGG ACCCACATGC 
CCCCACATCT TTGTGGCCAC CAACTTTCTG AGCCTTGTTC AGCTACAACT GCTGCCACAA 
GGGCCCCTGG TGCAGTATTT GACCATGGAG ACCTGTGAGG ATGGCAACGA TCTTGTCTTC 
TTCTATCAGG TTTGCGAAGG TGTTGCGAAG GCCAGCCATG CCTCCCACAC AGCTGCCCAG 
GCTGGGCTTC CTGACAAGCT TGTGGCTCGT GGCAAGGAGG TCTCAGACTT GATCCGCAGT 
GGAAAACCCA TCAAGCCTGT CAAGGATTTG CTAAAGAAGA ACCAAATGGA AAATTGCCAG 
ACATTAGTGG ATAAGTTTAT GAAACTGGAT TTGGAAGATC CTAACCTGGA CTTGAACGTT 
TTCATGAGCC AGGAAGTGCT GCCTGCTGCC ACCAGCATCC TCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MSH5 ( NM_172166.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_751898.1 Homo sapiens mutS homolog 5 (MSH5), transcript variant 4, mRNA.

Price & Availability↑

CloneID	OHu15753
Clone ID Related Accession (Same CDS sequence)	NM_002441.4 , NM_172166.3 , NM_172166.4
Accession Version	NM_172166.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2505bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-06-07
Organism	Homo sapiens(human)
Product	mutS protein homolog 5 isoform c
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL662899.5, DB448226.1, AF034759.1 and BF116106.1. This sequence is a reference standard in the RefSeqGene project. On Oct 30, 2009 this sequence version replaced NM_172166.2. Transcript Variant: This variant (4) uses alternate in-frame splice sites in both the central and 3' coding regions, compared to variant 1, resulting in an isoform (c) that is longer than isoform a. Both variants 3 and 4 encode the same isoform. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF034759.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on manual assertion, conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCCTCCT TAGGAGCGAA CCCAAGGAGG ACACCGCAGG GACCGAGACC TGGGGCGGCC 
TCCTCCGGCT TCCCCAGCCC GGCCCCAGTG CCGGGCCCCA GGGAGGCCGA GGAGGAGGAA 
GTCGAGGAGG AGGAGGAGCT GGCCGAGATC CATCTGTGTG TGCTGTGGAA TTCAGGATAC 
TTGGGCATTG CCTACTATGA TACTAGTGAC TCCACTATCC ACTTCATGCC AGATGCCCCA 
GACCACGAGA GCCTCAAGCT TCTCCAGAGA GTTCTGGATG AGATCAATCC CCAGTCTGTT 
GTTACGAGTG CCAAACAGGA TGAGAATATG ACTCGATTTC TGGGAAAGCT TGCCTCCCAG 
GAGCACAGAG AGCCTAAAAG ACCTGAAATC ATATTTTTGC CAAGTGTGGA TTTTGGTCTG 
GAGATAAGCA AACAACGCCT CCTTTCTGGA AACTACTCCT TCATCCCAGA CGCCATGACT 
GCCACTGAGA AAATCCTCTT CCTCTCTTCC ATTATTCCCT TTGACTGCCT CCTCACAGTT 
CGAGCACTTG GAGGGCTGCT GAAGTTCCTG GGTCGAAGAA GAATCGGGGT TGAACTGGAA 
GACTATAATG TCAGCGTCCC CATCCTGGGC TTTAAGAAAT TTATGTTGAC TCATCTGGTG 
AACATAGATC AAGACACTTA CAGTGTTCTA CAGATTTTTA AGAGTGAGTC TCACCCCTCA 
GTGTACAAAG TGGCCAGTGG ACTGAAGGAG GGGCTCAGCC TCTTTGGAAT CCTCAACAGA 
TGCCACTGTA AGTGGGGAGA GAAGCTGCTC AGGCTATGGT TCACACGTCC GACTCATGAC 
CTGGGGGAGC TCAGTTCTCG TCTGGACGTC ATTCAGTTTT TTCTGCTGCC CCAGAATCTG 
GACATGGCTC AGATGCTGCA TCGGCTCCTG GGTCACATCA AGAACGTGCC TCTGATTCTG 
AAACGCATGA AGTTGTCCCA CACCAAGGTC AGCGACTGGC AGGTTCTCTA CAAGACTGTG 
TACAGTGCCC TGGGCCTGAG GGATGCCTGC CGCTCCCTGC CGCAGTCCAT CCAGCTCTTT 
CGGGACATTG CCCAAGAGTT CTCTGATGAC CTGCACCATA TCGCCAGCCT CATTGGGAAA 
GTAGTGGACT TTGAGGGCAG CCTTGCTGAA AATCGCTTCA CAGTCCTCCC CAACATAGAT 
CCTGAAATTG ATGAGAAAAA GCGAAGACTG ATGGGACTTC CCAGTTTCCT TACTGAGGTT 
GCCCGCAAGG AGCTGGAGAA TCTGGACTCC CGTATTCCTT CATGCAGTGT CATCTACATC 
CCTCTGATTG GCTTCCTTCT TTCTATTCCC CGCCTGCCTT CCATGGTAGA GGCCAGTGAC 
TTTGAGATTA ATGGACTGGA CTTCATGTTT CTCTCAGAGG AGAAGCTGCA CTATCGTAGT 
GCCCGAACCA AGGAGCTGGA TGCATTGCTG GGGGACCTGC ACTGCGAGAT CCGGGACCAG 
GAGACGCTGC TGATGTACCA GCTACAGTGC CAGGTGCTGG CACGAGCAGC TGTCTTAACC 
CGAGTATTGG ACCTTGCCTC CCGCCTGGAC GTCCTGCTGG CTCTTGCCAG TGCTGCCCGG 
GACTATGGCT ACTCAAGGCC GCGTTACTCC CCACAAGTCC TTGGGGTACG AATCCAGAAT 
GGCAGACATC CTCTGATGGA ACTCTGTGCC CGAACCTTTG TGCCCAACTC CACAGAATGT 
GGTGGGGACA AAGGGAGGGT CAAAGTCATC ACTGGACCCA ACTCATCAGG GAAGAGCATA 
TACCTCAAAC AGGTAGGCTT GATCACATTC ATGGCCCTGG TAGGCAGCTT TGTGCCAGCA 
GAGGAGGCCG AAATTGGGGC AGTAGACGCC ATCTTCACAC GAATTCATAG CTGCGAATCC 
ATCTCCCTTG GCCTCTCCAC CTTCATGATC GACCTCAACC AGGTGGCGAA AGCAGTGAAC 
AATGCCACTG CACAGTCGCT GGTCCTTATT GATGAATTTG GAAAGGGAAC CAACACGGTG 
GATGGGCTCG CGCTTCTGGC CGCTGTGCTC CGACACTGGC TGGCACGTGG ACCCACATGC 
CCCCACATCT TTGTGGCCAC CAACTTTCTG AGCCTTGTTC AGCTACAACT GCTGCCACAA 
GGGCCCCTGG TGCAGTATTT GACCATGGAG ACCTGTGAGG ATGGCAACGA TCTTGTCTTC 
TTCTATCAGG TTTGCGAAGG TGTTGCGAAG GCCAGCCATG CCTCCCACAC AGCTGCCCAG 
GCTGGGCTTC CTGACAAGCT TGTGGCTCGT GGCAAGGAGG TCTCAGACTT GATCCGCAGT 
GGAAAACCCA TCAAGCCTGT CAAGGATTTG CTAAAGAAGA ACCAAATGGA AAATTGCCAG 
ACATTAGTGG ATAAGTTTAT GAAACTGGAT TTGGAAGATC CTAACCTGGA CTTGAACGTT 
TTCATGAGCC AGGAAGTGCT GCCTGCTGCC ACCAGCATCC TCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_751898.1
CDS	129..2633
Translation	MASLGANPRRTPQGPRPGAASSGFPSPAPVPGPREAEEEEVEEEEELAEIHLCVLWNSGYLGIAYYDTSDSTIHFMPDAPDHESLKLLQRVLDEINPQSVVTSAKQDENMTRFLGKLASQEHREPKRPEIIFLPSVDFGLEISKQRLLSGNYSFIPDAMTATEKILFLSSIIPFDCLLTVRALGGLLKFLGRRRIGVELEDYNVSVPILGFKKFMLTHLVNIDQDTYSVLQIFKSESHPSVYKVASGLKEGLSLFGILNRCHCKWGEKLLRLWFTRPTHDLGELSSRLDVIQFFLLPQNLDMAQMLHRLLGHIKNVPLILKRMKLSHTKVSDWQVLYKTVYSALGLRDACRSLPQSIQLFRDIAQEFSDDLHHIASLIGKVVDFEGSLAENRFTVLPNIDPEIDEKKRRLMGLPSFLTEVARKELENLDSRIPSCSVIYIPLIGFLLSIPRLPSMVEASDFEINGLDFMFLSEEKLHYRSARTKELDALLGDLHCEIRDQETLLMYQLQCQVLARAAVLTRVLDLASRLDVLLALASAARDYGYSRPRYSPQVLGVRIQNGRHPLMELCARTFVPNSTECGGDKGRVKVITGPNSSGKSIYLKQVGLITFMALVGSFVPAEEAEIGAVDAIFTRIHSCESISLGLSTFMIDLNQVAKAVNNATAQSLVLIDEFGKGTNTVDGLALLAAVLRHWLARGPTCPHIFVATNFLSLVQLQLLPQGPLVQYLTMETCEDGNDLVFFYQVCEGVAKASHASHTAAQAGLPDKLVARGKEVSDLIRSGKPIKPVKDLLKKNQMENCQTLVDKFMKLDLEDPNLDLNVFMSQEVLPAATSIL

Target ORF information:

RefSeq Version	NM_172166.3
Organism	Homo sapiens(human)
Definition	Homo sapiens mutS homolog 5 (MSH5), transcript variant 4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_172166.3

ORF Insert Sequence:

ATGGCCTCCT TAGGAGCGAA CCCAAGGAGG ACACCGCAGG GACCGAGACC TGGGGCGGCC 
TCCTCCGGCT TCCCCAGCCC GGCCCCAGTG CCGGGCCCCA GGGAGGCCGA GGAGGAGGAA 
GTCGAGGAGG AGGAGGAGCT GGCCGAGATC CATCTGTGTG TGCTGTGGAA TTCAGGATAC 
TTGGGCATTG CCTACTATGA TACTAGTGAC TCCACTATCC ACTTCATGCC AGATGCCCCA 
GACCACGAGA GCCTCAAGCT TCTCCAGAGA GTTCTGGATG AGATCAATCC CCAGTCTGTT 
GTTACGAGTG CCAAACAGGA TGAGAATATG ACTCGATTTC TGGGAAAGCT TGCCTCCCAG 
GAGCACAGAG AGCCTAAAAG ACCTGAAATC ATATTTTTGC CAAGTGTGGA TTTTGGTCTG 
GAGATAAGCA AACAACGCCT CCTTTCTGGA AACTACTCCT TCATCCCAGA CGCCATGACT 
GCCACTGAGA AAATCCTCTT CCTCTCTTCC ATTATTCCCT TTGACTGCCT CCTCACAGTT 
CGAGCACTTG GAGGGCTGCT GAAGTTCCTG GGTCGAAGAA GAATCGGGGT TGAACTGGAA 
GACTATAATG TCAGCGTCCC CATCCTGGGC TTTAAGAAAT TTATGTTGAC TCATCTGGTG 
AACATAGATC AAGACACTTA CAGTGTTCTA CAGATTTTTA AGAGTGAGTC TCACCCCTCA 
GTGTACAAAG TGGCCAGTGG ACTGAAGGAG GGGCTCAGCC TCTTTGGAAT CCTCAACAGA 
TGCCACTGTA AGTGGGGAGA GAAGCTGCTC AGGCTATGGT TCACACGTCC GACTCATGAC 
CTGGGGGAGC TCAGTTCTCG TCTGGACGTC ATTCAGTTTT TTCTGCTGCC CCAGAATCTG 
GACATGGCTC AGATGCTGCA TCGGCTCCTG GGTCACATCA AGAACGTGCC TCTGATTCTG 
AAACGCATGA AGTTGTCCCA CACCAAGGTC AGCGACTGGC AGGTTCTCTA CAAGACTGTG 
TACAGTGCCC TGGGCCTGAG GGATGCCTGC CGCTCCCTGC CGCAGTCCAT CCAGCTCTTT 
CGGGACATTG CCCAAGAGTT CTCTGATGAC CTGCACCATA TCGCCAGCCT CATTGGGAAA 
GTAGTGGACT TTGAGGGCAG CCTTGCTGAA AATCGCTTCA CAGTCCTCCC CAACATAGAT 
CCTGAAATTG ATGAGAAAAA GCGAAGACTG ATGGGACTTC CCAGTTTCCT TACTGAGGTT 
GCCCGCAAGG AGCTGGAGAA TCTGGACTCC CGTATTCCTT CATGCAGTGT CATCTACATC 
CCTCTGATTG GCTTCCTTCT TTCTATTCCC CGCCTGCCTT CCATGGTAGA GGCCAGTGAC 
TTTGAGATTA ATGGACTGGA CTTCATGTTT CTCTCAGAGG AGAAGCTGCA CTATCGTAGT 
GCCCGAACCA AGGAGCTGGA TGCATTGCTG GGGGACCTGC ACTGCGAGAT CCGGGACCAG 
GAGACGCTGC TGATGTACCA GCTACAGTGC CAGGTGCTGG CACGAGCAGC TGTCTTAACC 
CGAGTATTGG ACCTTGCCTC CCGCCTGGAC GTCCTGCTGG CTCTTGCCAG TGCTGCCCGG 
GACTATGGCT ACTCAAGGCC GCGTTACTCC CCACAAGTCC TTGGGGTACG AATCCAGAAT 
GGCAGACATC CTCTGATGGA ACTCTGTGCC CGAACCTTTG TGCCCAACTC CACAGAATGT 
GGTGGGGACA AAGGGAGGGT CAAAGTCATC ACTGGACCCA ACTCATCAGG GAAGAGCATA 
TACCTCAAAC AGGTAGGCTT GATCACATTC ATGGCCCTGG TAGGCAGCTT TGTGCCAGCA 
GAGGAGGCCG AAATTGGGGC AGTAGACGCC ATCTTCACAC GAATTCATAG CTGCGAATCC 
ATCTCCCTTG GCCTCTCCAC CTTCATGATC GACCTCAACC AGGTGGCGAA AGCAGTGAAC 
AATGCCACTG CACAGTCGCT GGTCCTTATT GATGAATTTG GAAAGGGAAC CAACACGGTG 
GATGGGCTCG CGCTTCTGGC CGCTGTGCTC CGACACTGGC TGGCACGTGG ACCCACATGC 
CCCCACATCT TTGTGGCCAC CAACTTTCTG AGCCTTGTTC AGCTACAACT GCTGCCACAA 
GGGCCCCTGG TGCAGTATTT GACCATGGAG ACCTGTGAGG ATGGCAACGA TCTTGTCTTC 
TTCTATCAGG TTTGCGAAGG TGTTGCGAAG GCCAGCCATG CCTCCCACAC AGCTGCCCAG 
GCTGGGCTTC CTGACAAGCT TGTGGCTCGT GGCAAGGAGG TCTCAGACTT GATCCGCAGT 
GGAAAACCCA TCAAGCCTGT CAAGGATTTG CTAAAGAAGA ACCAAATGGA AAATTGCCAG 
ACATTAGTGG ATAAGTTTAT GAAACTGGAT TTGGAAGATC CTAACCTGGA CTTGAACGTT 
TTCATGAGCC AGGAAGTGCT GCCTGCTGCC ACCAGCATCC TCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MSH5 ( NM_172166.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_751898.1 Homo sapiens mutS homolog 5 (MSH5), transcript variant 4, mRNA.

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CloneID	OHu15753
Clone ID Related Accession (Same CDS sequence)	NM_002441.4 , NM_172166.3 , NM_172166.4
Accession Version	NM_172166.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2505bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-30
Organism	Homo sapiens(human)
Product	mutS protein homolog 5 isoform c
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB448226.1, AF034759.1 and BF116106.1. On Aug 31, 2019 this sequence version replaced NM_172166.3. Transcript Variant: This variant (4) uses alternate in-frame splice sites in both the central and 3' coding regions, compared to variant 1, resulting in an isoform (c) that is longer than isoform a. Both variants 3 and 4 encode the same isoform. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF034759.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on manual assertion, conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCCTCCT TAGGAGCGAA CCCAAGGAGG ACACCGCAGG GACCGAGACC TGGGGCGGCC 
TCCTCCGGCT TCCCCAGCCC GGCCCCAGTG CCGGGCCCCA GGGAGGCCGA GGAGGAGGAA 
GTCGAGGAGG AGGAGGAGCT GGCCGAGATC CATCTGTGTG TGCTGTGGAA TTCAGGATAC 
TTGGGCATTG CCTACTATGA TACTAGTGAC TCCACTATCC ACTTCATGCC AGATGCCCCA 
GACCACGAGA GCCTCAAGCT TCTCCAGAGA GTTCTGGATG AGATCAATCC CCAGTCTGTT 
GTTACGAGTG CCAAACAGGA TGAGAATATG ACTCGATTTC TGGGAAAGCT TGCCTCCCAG 
GAGCACAGAG AGCCTAAAAG ACCTGAAATC ATATTTTTGC CAAGTGTGGA TTTTGGTCTG 
GAGATAAGCA AACAACGCCT CCTTTCTGGA AACTACTCCT TCATCCCAGA CGCCATGACT 
GCCACTGAGA AAATCCTCTT CCTCTCTTCC ATTATTCCCT TTGACTGCCT CCTCACAGTT 
CGAGCACTTG GAGGGCTGCT GAAGTTCCTG GGTCGAAGAA GAATCGGGGT TGAACTGGAA 
GACTATAATG TCAGCGTCCC CATCCTGGGC TTTAAGAAAT TTATGTTGAC TCATCTGGTG 
AACATAGATC AAGACACTTA CAGTGTTCTA CAGATTTTTA AGAGTGAGTC TCACCCCTCA 
GTGTACAAAG TGGCCAGTGG ACTGAAGGAG GGGCTCAGCC TCTTTGGAAT CCTCAACAGA 
TGCCACTGTA AGTGGGGAGA GAAGCTGCTC AGGCTATGGT TCACACGTCC GACTCATGAC 
CTGGGGGAGC TCAGTTCTCG TCTGGACGTC ATTCAGTTTT TTCTGCTGCC CCAGAATCTG 
GACATGGCTC AGATGCTGCA TCGGCTCCTG GGTCACATCA AGAACGTGCC TCTGATTCTG 
AAACGCATGA AGTTGTCCCA CACCAAGGTC AGCGACTGGC AGGTTCTCTA CAAGACTGTG 
TACAGTGCCC TGGGCCTGAG GGATGCCTGC CGCTCCCTGC CGCAGTCCAT CCAGCTCTTT 
CGGGACATTG CCCAAGAGTT CTCTGATGAC CTGCACCATA TCGCCAGCCT CATTGGGAAA 
GTAGTGGACT TTGAGGGCAG CCTTGCTGAA AATCGCTTCA CAGTCCTCCC CAACATAGAT 
CCTGAAATTG ATGAGAAAAA GCGAAGACTG ATGGGACTTC CCAGTTTCCT TACTGAGGTT 
GCCCGCAAGG AGCTGGAGAA TCTGGACTCC CGTATTCCTT CATGCAGTGT CATCTACATC 
CCTCTGATTG GCTTCCTTCT TTCTATTCCC CGCCTGCCTT CCATGGTAGA GGCCAGTGAC 
TTTGAGATTA ATGGACTGGA CTTCATGTTT CTCTCAGAGG AGAAGCTGCA CTATCGTAGT 
GCCCGAACCA AGGAGCTGGA TGCATTGCTG GGGGACCTGC ACTGCGAGAT CCGGGACCAG 
GAGACGCTGC TGATGTACCA GCTACAGTGC CAGGTGCTGG CACGAGCAGC TGTCTTAACC 
CGAGTATTGG ACCTTGCCTC CCGCCTGGAC GTCCTGCTGG CTCTTGCCAG TGCTGCCCGG 
GACTATGGCT ACTCAAGGCC GCGTTACTCC CCACAAGTCC TTGGGGTACG AATCCAGAAT 
GGCAGACATC CTCTGATGGA ACTCTGTGCC CGAACCTTTG TGCCCAACTC CACAGAATGT 
GGTGGGGACA AAGGGAGGGT CAAAGTCATC ACTGGACCCA ACTCATCAGG GAAGAGCATA 
TACCTCAAAC AGGTAGGCTT GATCACATTC ATGGCCCTGG TAGGCAGCTT TGTGCCAGCA 
GAGGAGGCCG AAATTGGGGC AGTAGACGCC ATCTTCACAC GAATTCATAG CTGCGAATCC 
ATCTCCCTTG GCCTCTCCAC CTTCATGATC GACCTCAACC AGGTGGCGAA AGCAGTGAAC 
AATGCCACTG CACAGTCGCT GGTCCTTATT GATGAATTTG GAAAGGGAAC CAACACGGTG 
GATGGGCTCG CGCTTCTGGC CGCTGTGCTC CGACACTGGC TGGCACGTGG ACCCACATGC 
CCCCACATCT TTGTGGCCAC CAACTTTCTG AGCCTTGTTC AGCTACAACT GCTGCCACAA 
GGGCCCCTGG TGCAGTATTT GACCATGGAG ACCTGTGAGG ATGGCAACGA TCTTGTCTTC 
TTCTATCAGG TTTGCGAAGG TGTTGCGAAG GCCAGCCATG CCTCCCACAC AGCTGCCCAG 
GCTGGGCTTC CTGACAAGCT TGTGGCTCGT GGCAAGGAGG TCTCAGACTT GATCCGCAGT 
GGAAAACCCA TCAAGCCTGT CAAGGATTTG CTAAAGAAGA ACCAAATGGA AAATTGCCAG 
ACATTAGTGG ATAAGTTTAT GAAACTGGAT TTGGAAGATC CTAACCTGGA CTTGAACGTT 
TTCATGAGCC AGGAAGTGCT GCCTGCTGCC ACCAGCATCC TCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_751898.1
CDS	72..2576
Translation	MASLGANPRRTPQGPRPGAASSGFPSPAPVPGPREAEEEEVEEEEELAEIHLCVLWNSGYLGIAYYDTSDSTIHFMPDAPDHESLKLLQRVLDEINPQSVVTSAKQDENMTRFLGKLASQEHREPKRPEIIFLPSVDFGLEISKQRLLSGNYSFIPDAMTATEKILFLSSIIPFDCLLTVRALGGLLKFLGRRRIGVELEDYNVSVPILGFKKFMLTHLVNIDQDTYSVLQIFKSESHPSVYKVASGLKEGLSLFGILNRCHCKWGEKLLRLWFTRPTHDLGELSSRLDVIQFFLLPQNLDMAQMLHRLLGHIKNVPLILKRMKLSHTKVSDWQVLYKTVYSALGLRDACRSLPQSIQLFRDIAQEFSDDLHHIASLIGKVVDFEGSLAENRFTVLPNIDPEIDEKKRRLMGLPSFLTEVARKELENLDSRIPSCSVIYIPLIGFLLSIPRLPSMVEASDFEINGLDFMFLSEEKLHYRSARTKELDALLGDLHCEIRDQETLLMYQLQCQVLARAAVLTRVLDLASRLDVLLALASAARDYGYSRPRYSPQVLGVRIQNGRHPLMELCARTFVPNSTECGGDKGRVKVITGPNSSGKSIYLKQVGLITFMALVGSFVPAEEAEIGAVDAIFTRIHSCESISLGLSTFMIDLNQVAKAVNNATAQSLVLIDEFGKGTNTVDGLALLAAVLRHWLARGPTCPHIFVATNFLSLVQLQLLPQGPLVQYLTMETCEDGNDLVFFYQVCEGVAKASHASHTAAQAGLPDKLVARGKEVSDLIRSGKPIKPVKDLLKKNQMENCQTLVDKFMKLDLEDPNLDLNVFMSQEVLPAATSIL

Target ORF information:

RefSeq Version	NM_172166.4
Organism	Homo sapiens(human)
Definition	Homo sapiens mutS homolog 5 (MSH5), transcript variant 4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_172166.4

ORF Insert Sequence:

ATGGCCTCCT TAGGAGCGAA CCCAAGGAGG ACACCGCAGG GACCGAGACC TGGGGCGGCC 
TCCTCCGGCT TCCCCAGCCC GGCCCCAGTG CCGGGCCCCA GGGAGGCCGA GGAGGAGGAA 
GTCGAGGAGG AGGAGGAGCT GGCCGAGATC CATCTGTGTG TGCTGTGGAA TTCAGGATAC 
TTGGGCATTG CCTACTATGA TACTAGTGAC TCCACTATCC ACTTCATGCC AGATGCCCCA 
GACCACGAGA GCCTCAAGCT TCTCCAGAGA GTTCTGGATG AGATCAATCC CCAGTCTGTT 
GTTACGAGTG CCAAACAGGA TGAGAATATG ACTCGATTTC TGGGAAAGCT TGCCTCCCAG 
GAGCACAGAG AGCCTAAAAG ACCTGAAATC ATATTTTTGC CAAGTGTGGA TTTTGGTCTG 
GAGATAAGCA AACAACGCCT CCTTTCTGGA AACTACTCCT TCATCCCAGA CGCCATGACT 
GCCACTGAGA AAATCCTCTT CCTCTCTTCC ATTATTCCCT TTGACTGCCT CCTCACAGTT 
CGAGCACTTG GAGGGCTGCT GAAGTTCCTG GGTCGAAGAA GAATCGGGGT TGAACTGGAA 
GACTATAATG TCAGCGTCCC CATCCTGGGC TTTAAGAAAT TTATGTTGAC TCATCTGGTG 
AACATAGATC AAGACACTTA CAGTGTTCTA CAGATTTTTA AGAGTGAGTC TCACCCCTCA 
GTGTACAAAG TGGCCAGTGG ACTGAAGGAG GGGCTCAGCC TCTTTGGAAT CCTCAACAGA 
TGCCACTGTA AGTGGGGAGA GAAGCTGCTC AGGCTATGGT TCACACGTCC GACTCATGAC 
CTGGGGGAGC TCAGTTCTCG TCTGGACGTC ATTCAGTTTT TTCTGCTGCC CCAGAATCTG 
GACATGGCTC AGATGCTGCA TCGGCTCCTG GGTCACATCA AGAACGTGCC TCTGATTCTG 
AAACGCATGA AGTTGTCCCA CACCAAGGTC AGCGACTGGC AGGTTCTCTA CAAGACTGTG 
TACAGTGCCC TGGGCCTGAG GGATGCCTGC CGCTCCCTGC CGCAGTCCAT CCAGCTCTTT 
CGGGACATTG CCCAAGAGTT CTCTGATGAC CTGCACCATA TCGCCAGCCT CATTGGGAAA 
GTAGTGGACT TTGAGGGCAG CCTTGCTGAA AATCGCTTCA CAGTCCTCCC CAACATAGAT 
CCTGAAATTG ATGAGAAAAA GCGAAGACTG ATGGGACTTC CCAGTTTCCT TACTGAGGTT 
GCCCGCAAGG AGCTGGAGAA TCTGGACTCC CGTATTCCTT CATGCAGTGT CATCTACATC 
CCTCTGATTG GCTTCCTTCT TTCTATTCCC CGCCTGCCTT CCATGGTAGA GGCCAGTGAC 
TTTGAGATTA ATGGACTGGA CTTCATGTTT CTCTCAGAGG AGAAGCTGCA CTATCGTAGT 
GCCCGAACCA AGGAGCTGGA TGCATTGCTG GGGGACCTGC ACTGCGAGAT CCGGGACCAG 
GAGACGCTGC TGATGTACCA GCTACAGTGC CAGGTGCTGG CACGAGCAGC TGTCTTAACC 
CGAGTATTGG ACCTTGCCTC CCGCCTGGAC GTCCTGCTGG CTCTTGCCAG TGCTGCCCGG 
GACTATGGCT ACTCAAGGCC GCGTTACTCC CCACAAGTCC TTGGGGTACG AATCCAGAAT 
GGCAGACATC CTCTGATGGA ACTCTGTGCC CGAACCTTTG TGCCCAACTC CACAGAATGT 
GGTGGGGACA AAGGGAGGGT CAAAGTCATC ACTGGACCCA ACTCATCAGG GAAGAGCATA 
TACCTCAAAC AGGTAGGCTT GATCACATTC ATGGCCCTGG TAGGCAGCTT TGTGCCAGCA 
GAGGAGGCCG AAATTGGGGC AGTAGACGCC ATCTTCACAC GAATTCATAG CTGCGAATCC 
ATCTCCCTTG GCCTCTCCAC CTTCATGATC GACCTCAACC AGGTGGCGAA AGCAGTGAAC 
AATGCCACTG CACAGTCGCT GGTCCTTATT GATGAATTTG GAAAGGGAAC CAACACGGTG 
GATGGGCTCG CGCTTCTGGC CGCTGTGCTC CGACACTGGC TGGCACGTGG ACCCACATGC 
CCCCACATCT TTGTGGCCAC CAACTTTCTG AGCCTTGTTC AGCTACAACT GCTGCCACAA 
GGGCCCCTGG TGCAGTATTT GACCATGGAG ACCTGTGAGG ATGGCAACGA TCTTGTCTTC 
TTCTATCAGG TTTGCGAAGG TGTTGCGAAG GCCAGCCATG CCTCCCACAC AGCTGCCCAG 
GCTGGGCTTC CTGACAAGCT TGTGGCTCGT GGCAAGGAGG TCTCAGACTT GATCCGCAGT 
GGAAAACCCA TCAAGCCTGT CAAGGATTTG CTAAAGAAGA ACCAAATGGA AAATTGCCAG 
ACATTAGTGG ATAAGTTTAT GAAACTGGAT TTGGAAGATC CTAACCTGGA CTTGAACGTT 
TTCATGAGCC AGGAAGTGCT GCCTGCTGCC ACCAGCATCC TCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Mutations in MSH5 in primary ovarian insufficiency.
Human molecular genetics26(8)1452-1457(2017 04)
Guo T,Zhao S,Zhao S,Chen M,Li G,Jiao X,Wang Z,Zhao Y,Qin Y,Gao F,Chen ZJ

Association between DNA mismatch repair gene polymorphisms and platinum-based chemotherapy toxicity in non-small cell lung cancer patients.
Chinese journal of cancer36(1)12(2017 Jan)
Liu JY,Qian CY,Gao YF,Chen J,Zhou HH,Yin JY

hMSH4-hMSH5 adenosine nucleotide processing and interactions with homologous recombination machinery.
The Journal of biological chemistry283(1)145-54(2008 Jan)
Snowden T,Shim KS,Schmutte C,Acharya S,Fishel R

Role for Msh5 in the regulation of Ig class switch recombination.
Proceedings of the National Academy of Sciences of the United States of America104(17)7193-8(2007 Apr)
Sekine H,Ferreira RC,Pan-Hammarstr?m Q,Graham RR,Ziemba B,de Vries SS,Liu J,Hippen K,Koeuth T,Ortmann W,Iwahori A,Elliott MK,Offer S,Skon C,Du L,Novitzke J,Lee AT,Zhao N,Tompkins JD,Altshuler D,Gregersen PK,Cunningham-Rundles C,Harris RS,Her C,Nelson DL,Hammarstr?m L,Gilkeson GS,Behrens TW

Two variants of MutS homolog hMSH5: prevalence in humans and effects on protein interaction.
Biochemical and biophysical research communications332(2)524-32(2005 Jul)
Yi W,Wu X,Lee TH,Doggett NA,Her C

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MSH5 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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