LMOD2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	LMOD2
Entrez Gene ID	442721
Full Name	leiomodin 2
Synonyms	C-LMOD,CLMOD
General protein information	Preferred Names leiomodin 2 Names leiomodin-2 cardiac leiomodin leiomodin 2 (cardiac)
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 7 Map Location: 7q31.32
Disorder MIM:	608006

mRNA and Protein(s)

mRNA	Protein	Name
NM_207163.2	NP_997046.1	leiomodin-2
NM_207163.3	NP_997046.1	leiomodin-2

Pathways from BioSystems

Homologies

Gallus gallus (chicken)	LMOD2	NP_001186644.1
Pan troglodytes (chimpanzee)	LMOD2	XP_001148473.2
Canis lupus familiaris (dog)	LMOD2	XP_851676.3
Bos taurus (cattle)	LMOD2	NP_001098857.1
Rattus norvegicus (Norway rat)	Lmod2	NP_001094434.1
Rattus norvegicus (Norway rat)	LOC100909784	XP_003749755.1
	LMOD2	XP_002803500.1
Danio rerio (zebrafish)	lmod2b	XP_003198268.1
Xenopus tropicalis (tropical clawed frog)	lmod2	NP_001120284.1
Homo sapiens (human)	LMOD2	NP_997046.1
Mus musculus (house mouse)	Lmod2	NP_444328.1

Gene Ontology
Bibliography

Related articles in PubMed

Crystal Structure of Leiomodin 2 in Complex with Actin: A Structural and Functional Reexamination.
Boczkowska M, Yurtsever Z, Rebowski G, Eck MJ, Dominguez R
Biophysical journal113(4)889-899(2017 Aug)

Localization of the binding interface between leiomodin-2 and ?-tropomyosin.
Colpan M, Tolkatchev D, Grover S, Helms GL, Cort JR, Moroz N, Kostyukova AS
Biochimica et biophysica acta1864(5)523-30(2016 May)

Mechanisms of leiomodin 2-mediated regulation of actin filament in muscle cells.
Chen X, Ni F, Kondrashkina E, Ma J, Wang Q
Proceedings of the National Academy of Sciences of the United States of America112(41)12687-92(2015 Oct)

How Leiomodin and Tropomodulin use a common fold for different actin assembly functions.
Boczkowska M, Rebowski G, Kremneva E, Lappalainen P, Dominguez R
Nature communications68314(2015 Sep)

Leiomodin-3 dysfunction results in thin filament disorganization and nemaline myopathy.
Yuen M, Sandaradura SA, Dowling JJ, Kostyukova AS, Moroz N, Quinlan KG, Lehtokari VL, Ravenscroft G, Todd EJ, Ceyhan-Birsoy O, Gokhin DS, Maluenda J, Lek M, Nolent F, Pappas CT, Novak SM, D'Amico A, Malfatti E, Thomas BP, Gabriel SB, Gupta N, Daly MJ, Ilkovski B, Houweling PJ, Davidson AE, Swanson LC, Brownstein CA, Gupta VA, Medne L, Shannon P, Martin N, Bick DP, Flisberg A, Holmberg E, Van den Bergh P, Lapunzina P, Waddell LB, Sloboda DD, Bertini E, Chitayat D, Telfer WR, Laquerri?re A, Gregorio CC, Ottenheijm CA, B?nnemann CG, Pelin K, Beggs AH, Hayashi YK, Romero NB, Laing NG, Nishino I, Wallgren-Pettersson C, Melki J, Fowler VM, MacArthur DG, North KN, Clarke NF
The Journal of clinical investigation124(11)4693-708(2014 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Crystal Structure of Leiomodin 2 in Complex with Actin
Title: Crystal Structure of Leiomodin 2 in Complex with Actin: A Structural and Functional Reexamination.

The mutation reduced binding affinity for both Lmod2 and Tmod1. The effect of the K15N mutation on Tpm1.1 binding to Lmod2 and Tmod1 provides a molecular rationale for the development of familial dilated cardiomyopathies .
Title: Localization of the binding interface between leiomodin-2 and ?-tropomyosin.

Complementary functional studies suggest that the binding of Lmod2 stimulates ATP hydrolysis and accelerates actin nucleation and polymerization.
Title: Mechanisms of leiomodin 2-mediated regulation of actin filament in muscle cells.

The C-terminal extension of Lmod2 and C terminal of Tmod1 are sufficient to produce a filament nucleator.
Title: How Leiomodin and Tropomodulin use a common fold for different actin assembly functions.

study describes an actin-binding protein, leiomodin, that acted as a strong filament nucleator in muscle cells
Title: Leiomodin is an actin filament nucleator in muscle cells.

The following LMOD2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the LMOD2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu30928	NM_207163.3 Latest version!	Homo sapiens leiomodin 2 (LMOD2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$307.30 $439.00
View Old Accession Versions >>
OHu30928	NM_207163.2	Homo sapiens leiomodin 2 (LMOD2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$307.30 $439.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

LMOD2 ( NM_207163.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_997046.1 Homo sapiens leiomodin 2 (LMOD2), mRNA.

Price & Availability↑

CloneID	OHu30928
Clone ID Related Accession (Same CDS sequence)	NM_207163.2 , NM_207163.3
Accession Version	NM_207163.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1644bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-10
Organism	Homo sapiens(human)
Product	leiomodin-2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DC385641.1, BC017911.1, AC006333.3 and AA747115.1. On Jan 23, 2017 this sequence version replaced NM_207163.1. Sequence Note: The second exon was derived from genomic sequence in order to represent the transcript described in PMID 11318603, which is consistent with the mouse homolog. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMEA2144120, SAMEA2151741 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## inferred exon combination :: PMID: 11318603 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGTCTACCT TTGGCTACCG AAGAGGACTC AGTAAATACG AATCCATCGA CGAGGATGAA 
CTCCTCGCCT CCCTGTCAGC CGAGGAGCTG AAGGAGCTAG AGAGAGAGTT GGAAGACATT 
GAACCTGACC GCAACCTTCC CGTGGGGCTA AGGCAAAAGA GCCTGACAGA GAAAACCCCC 
ACAGGGACAT TCAGCAGAGA GGCACTGATG GCCTATTGGG AAAAGGAGTC CCAAAAACTC 
TTGGAGAAGG AGAGGCTGGG GGAATGTGGA AAGGTTGCAG AAGACAAAGA GGAAAGTGAA 
GAAGAGCTTA TCTTTACTGA AAGTAACAGT GAGGTTTCTG AGGAAGTGTA TACAGAGGAG 
GAGGAGGAGG AGTCCCAGGA GGAAGAGGAG GAAGAAGACA GTGACGAAGA GGAAAGAACA 
ATTGAAACTG CAAAAGGGAT TAATGGAACT GTAAATTATG ATAGTGTCAA TTCTGACAAC 
TCTAAGCCAA AGATATTTAA AAGTCAAATA GAGAACATAA ATTTGACCAA TGGCAGCAAT 
GGGAGGAACA CAGAGTCCCC AGCTGCCATT CACCCTTGTG GAAATCCTAC AGTGATTGAG 
GACGCTTTGG ACAAGATTAA AAGCAATGAC CCTGACACCA CAGAAGTCAA TTTGAACAAC 
ATTGAGAACA TCACAACACA GACCCTTACC CGCTTTGCTG AAGCCCTCAA GGACAACACT 
GTGGTGAAGA CGTTCAGTCT GGCCAACACG CATGCCGACG ACAGTGCAGC CATGGCCATT 
GCAGAGATGC TCAAAGTCAA TGAGCACATC ACCAACGTAA ACGTCGAGTC CAACTTCATA 
ACGGGAAAGG GGATCCTGGC CATCATGAGA GCTCTCCAGC ACAACACGGT GCTCACGGAG 
CTGCGTTTCC ATAACCAGAG GCACATCATG GGCAGCCAGG TGGAAATGGA GATTGTCAAG 
CTGCTGAAGG AGAACACGAC GCTGCTGAGG CTGGGATACC ATTTTGAACT CCCAGGACCA 
AGAATGAGCA TGACGAGCAT TTTGACAAGA AATATGGATA AACAGAGGCA AAAACGTTTG 
CAGGAGCAAA AACAGCAGGA GGGATACGAT GGAGGACCCA ATCTTAGGAC CAAAGTCTGG 
CAAAGAGGAA CACCTAGCTC TTCACCTTAT GTATCTCCCA GGCACTCACC CTGGTCATCC 
CCAAAACTCC CCAAAAAAGT CCAGACTGTG AGGAGCCGTC CTCTGTCTCC TGTGGCCACA 
CCTCCTCCTC CTCCCCCTCC TCCTCCTCCT CCCCCTCCTT CTTCCCAAAG GCTGCCACCA 
CCTCCTCCTC CTCCCCCTCC TCCACTCCCA GAGAAAAAGC TCATTACCAG AAACATTGCA 
GAAGTCATCA AACAACAGGA GAGTGCCCAA CGGGCATTAC AAAATGGACA AAAAAAGAAA 
AAAGGGAAAA AGGTCAAGAA ACAGCCAAAC AGTATTCTAA AGGAAATAAA AAATTCTCTG 
AGGTCAGTGC AAGAGAAGAA AATGGAAGAC AGTTCCCGAC CTTCTACCCC ACAGAGATCA 
GCTCATGAGA ATCTCATGGA AGCAATTCGG GGAAGCAGCA TAAAACAGCT AAAGCGGGTG 
GAAGTTCCAG AAGCCCTGCG ATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_997046.1
CDS	158..1801
Translation	MSTFGYRRGLSKYESIDEDELLASLSAEELKELERELEDIEPDRNLPVGLRQKSLTEKTPTGTFSREALMAYWEKESQKLLEKERLGECGKVAEDKEESEEELIFTESNSEVSEEVYTEEEEEESQEEEEEEDSDEEERTIETAKGINGTVNYDSVNSDNSKPKIFKSQIENINLTNGSNGRNTESPAAIHPCGNPTVIEDALDKIKSNDPDTTEVNLNNIENITTQTLTRFAEALKDNTVVKTFSLANTHADDSAAMAIAEMLKVNEHITNVNVESNFITGKGILAIMRALQHNTVLTELRFHNQRHIMGSQVEMEIVKLLKENTTLLRLGYHFELPGPRMSMTSILTRNMDKQRQKRLQEQKQQEGYDGGPNLRTKVWQRGTPSSSPYVSPRHSPWSSPKLPKKVQTVRSRPLSPVATPPPPPPPPPPPPPSSQRLPPPPPPPPPPLPEKKLITRNIAEVIKQQESAQRALQNGQKKKKGKKVKKQPNSILKEIKNSLRSVQEKKMEDSSRPSTPQRSAHENLMEAIRGSSIKQLKRVEVPEALR

Target ORF information:

RefSeq Version	NM_207163.2
Organism	Homo sapiens(human)
Definition	Homo sapiens leiomodin 2 (LMOD2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_207163.2

ORF Insert Sequence:

ATGTCTACCT TTGGCTACCG AAGAGGACTC AGTAAATACG AATCCATCGA CGAGGATGAA 
CTCCTCGCCT CCCTGTCAGC CGAGGAGCTG AAGGAGCTAG AGAGAGAGTT GGAAGACATT 
GAACCTGACC GCAACCTTCC CGTGGGGCTA AGGCAAAAGA GCCTGACAGA GAAAACCCCC 
ACAGGGACAT TCAGCAGAGA GGCACTGATG GCCTATTGGG AAAAGGAGTC CCAAAAACTC 
TTGGAGAAGG AGAGGCTGGG GGAATGTGGA AAGGTTGCAG AAGACAAAGA GGAAAGTGAA 
GAAGAGCTTA TCTTTACTGA AAGTAACAGT GAGGTTTCTG AGGAAGTGTA TACAGAGGAG 
GAGGAGGAGG AGTCCCAGGA GGAAGAGGAG GAAGAAGACA GTGACGAAGA GGAAAGAACA 
ATTGAAACTG CAAAAGGGAT TAATGGAACT GTAAATTATG ATAGTGTCAA TTCTGACAAC 
TCTAAGCCAA AGATATTTAA AAGTCAAATA GAGAACATAA ATTTGACCAA TGGCAGCAAT 
GGGAGGAACA CAGAGTCCCC AGCTGCCATT CACCCTTGTG GAAATCCTAC AGTGATTGAG 
GACGCTTTGG ACAAGATTAA AAGCAATGAC CCTGACACCA CAGAAGTCAA TTTGAACAAC 
ATTGAGAACA TCACAACACA GACCCTTACC CGCTTTGCTG AAGCCCTCAA GGACAACACT 
GTGGTGAAGA CGTTCAGTCT GGCCAACACG CATGCCGACG ACAGTGCAGC CATGGCCATT 
GCAGAGATGC TCAAAGTCAA TGAGCACATC ACCAACGTAA ACGTCGAGTC CAACTTCATA 
ACGGGAAAGG GGATCCTGGC CATCATGAGA GCTCTCCAGC ACAACACGGT GCTCACGGAG 
CTGCGTTTCC ATAACCAGAG GCACATCATG GGCAGCCAGG TGGAAATGGA GATTGTCAAG 
CTGCTGAAGG AGAACACGAC GCTGCTGAGG CTGGGATACC ATTTTGAACT CCCAGGACCA 
AGAATGAGCA TGACGAGCAT TTTGACAAGA AATATGGATA AACAGAGGCA AAAACGTTTG 
CAGGAGCAAA AACAGCAGGA GGGATACGAT GGAGGACCCA ATCTTAGGAC CAAAGTCTGG 
CAAAGAGGAA CACCTAGCTC TTCACCTTAT GTATCTCCCA GGCACTCACC CTGGTCATCC 
CCAAAACTCC CCAAAAAAGT CCAGACTGTG AGGAGCCGTC CTCTGTCTCC TGTGGCCACA 
CCTCCTCCTC CTCCCCCTCC TCCTCCTCCT CCCCCTCCTT CTTCCCAAAG GCTGCCACCA 
CCTCCTCCTC CTCCCCCTCC TCCACTCCCA GAGAAAAAGC TCATTACCAG AAACATTGCA 
GAAGTCATCA AACAACAGGA GAGTGCCCAA CGGGCATTAC AAAATGGACA AAAAAAGAAA 
AAAGGGAAAA AGGTCAAGAA ACAGCCAAAC AGTATTCTAA AGGAAATAAA AAATTCTCTG 
AGGTCAGTGC AAGAGAAGAA AATGGAAGAC AGTTCCCGAC CTTCTACCCC ACAGAGATCA 
GCTCATGAGA ATCTCATGGA AGCAATTCGG GGAAGCAGCA TAAAACAGCT AAAGCGGGTG 
GAAGTTCCAG AAGCCCTGCG ATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

LMOD2 ( NM_207163.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_997046.1 Homo sapiens leiomodin 2 (LMOD2), mRNA.

Price & Availability↑

CloneID	OHu30928
Clone ID Related Accession (Same CDS sequence)	NM_207163.2 , NM_207163.3
Accession Version	NM_207163.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1644bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-01
Organism	Homo sapiens(human)
Product	leiomodin-2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC017911.1, AC006333.3 and AA747115.1. On Nov 23, 2018 this sequence version replaced NM_207163.2. Sequence Note: The second exon was derived from genomic sequence in order to represent the transcript described in PMID 11318603, which is consistent with the mouse homolog. ##Evidence-Data-START## Transcript exon combination :: SRR5189655.140387.1, SRR5189655.175397.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2144120, SAMEA2151741 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000458573.3/ ENSP00000411932.2 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGTCTACCT TTGGCTACCG AAGAGGACTC AGTAAATACG AATCCATCGA CGAGGATGAA 
CTCCTCGCCT CCCTGTCAGC CGAGGAGCTG AAGGAGCTAG AGAGAGAGTT GGAAGACATT 
GAACCTGACC GCAACCTTCC CGTGGGGCTA AGGCAAAAGA GCCTGACAGA GAAAACCCCC 
ACAGGGACAT TCAGCAGAGA GGCACTGATG GCCTATTGGG AAAAGGAGTC CCAAAAACTC 
TTGGAGAAGG AGAGGCTGGG GGAATGTGGA AAGGTTGCAG AAGACAAAGA GGAAAGTGAA 
GAAGAGCTTA TCTTTACTGA AAGTAACAGT GAGGTTTCTG AGGAAGTGTA TACAGAGGAG 
GAGGAGGAGG AGTCCCAGGA GGAAGAGGAG GAAGAAGACA GTGACGAAGA GGAAAGAACA 
ATTGAAACTG CAAAAGGGAT TAATGGAACT GTAAATTATG ATAGTGTCAA TTCTGACAAC 
TCTAAGCCAA AGATATTTAA AAGTCAAATA GAGAACATAA ATTTGACCAA TGGCAGCAAT 
GGGAGGAACA CAGAGTCCCC AGCTGCCATT CACCCTTGTG GAAATCCTAC AGTGATTGAG 
GACGCTTTGG ACAAGATTAA AAGCAATGAC CCTGACACCA CAGAAGTCAA TTTGAACAAC 
ATTGAGAACA TCACAACACA GACCCTTACC CGCTTTGCTG AAGCCCTCAA GGACAACACT 
GTGGTGAAGA CGTTCAGTCT GGCCAACACG CATGCCGACG ACAGTGCAGC CATGGCCATT 
GCAGAGATGC TCAAAGTCAA TGAGCACATC ACCAACGTAA ACGTCGAGTC CAACTTCATA 
ACGGGAAAGG GGATCCTGGC CATCATGAGA GCTCTCCAGC ACAACACGGT GCTCACGGAG 
CTGCGTTTCC ATAACCAGAG GCACATCATG GGCAGCCAGG TGGAAATGGA GATTGTCAAG 
CTGCTGAAGG AGAACACGAC GCTGCTGAGG CTGGGATACC ATTTTGAACT CCCAGGACCA 
AGAATGAGCA TGACGAGCAT TTTGACAAGA AATATGGATA AACAGAGGCA AAAACGTTTG 
CAGGAGCAAA AACAGCAGGA GGGATACGAT GGAGGACCCA ATCTTAGGAC CAAAGTCTGG 
CAAAGAGGAA CACCTAGCTC TTCACCTTAT GTATCTCCCA GGCACTCACC CTGGTCATCC 
CCAAAACTCC CCAAAAAAGT CCAGACTGTG AGGAGCCGTC CTCTGTCTCC TGTGGCCACA 
CCTCCTCCTC CTCCCCCTCC TCCTCCTCCT CCCCCTCCTT CTTCCCAAAG GCTGCCACCA 
CCTCCTCCTC CTCCCCCTCC TCCACTCCCA GAGAAAAAGC TCATTACCAG AAACATTGCA 
GAAGTCATCA AACAACAGGA GAGTGCCCAA CGGGCATTAC AAAATGGACA AAAAAAGAAA 
AAAGGGAAAA AGGTCAAGAA ACAGCCAAAC AGTATTCTAA AGGAAATAAA AAATTCTCTG 
AGGTCAGTGC AAGAGAAGAA AATGGAAGAC AGTTCCCGAC CTTCTACCCC ACAGAGATCA 
GCTCATGAGA ATCTCATGGA AGCAATTCGG GGAAGCAGCA TAAAACAGCT AAAGCGGGTG 
GAAGTTCCAG AAGCCCTGCG ATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_997046.1
CDS	99..1742
Translation	MSTFGYRRGLSKYESIDEDELLASLSAEELKELERELEDIEPDRNLPVGLRQKSLTEKTPTGTFSREALMAYWEKESQKLLEKERLGECGKVAEDKEESEEELIFTESNSEVSEEVYTEEEEEESQEEEEEEDSDEEERTIETAKGINGTVNYDSVNSDNSKPKIFKSQIENINLTNGSNGRNTESPAAIHPCGNPTVIEDALDKIKSNDPDTTEVNLNNIENITTQTLTRFAEALKDNTVVKTFSLANTHADDSAAMAIAEMLKVNEHITNVNVESNFITGKGILAIMRALQHNTVLTELRFHNQRHIMGSQVEMEIVKLLKENTTLLRLGYHFELPGPRMSMTSILTRNMDKQRQKRLQEQKQQEGYDGGPNLRTKVWQRGTPSSSPYVSPRHSPWSSPKLPKKVQTVRSRPLSPVATPPPPPPPPPPPPPSSQRLPPPPPPPPPPLPEKKLITRNIAEVIKQQESAQRALQNGQKKKKGKKVKKQPNSILKEIKNSLRSVQEKKMEDSSRPSTPQRSAHENLMEAIRGSSIKQLKRVEVPEALR

Target ORF information:

RefSeq Version	NM_207163.3
Organism	Homo sapiens(human)
Definition	Homo sapiens leiomodin 2 (LMOD2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_207163.3

ORF Insert Sequence:

ATGTCTACCT TTGGCTACCG AAGAGGACTC AGTAAATACG AATCCATCGA CGAGGATGAA 
CTCCTCGCCT CCCTGTCAGC CGAGGAGCTG AAGGAGCTAG AGAGAGAGTT GGAAGACATT 
GAACCTGACC GCAACCTTCC CGTGGGGCTA AGGCAAAAGA GCCTGACAGA GAAAACCCCC 
ACAGGGACAT TCAGCAGAGA GGCACTGATG GCCTATTGGG AAAAGGAGTC CCAAAAACTC 
TTGGAGAAGG AGAGGCTGGG GGAATGTGGA AAGGTTGCAG AAGACAAAGA GGAAAGTGAA 
GAAGAGCTTA TCTTTACTGA AAGTAACAGT GAGGTTTCTG AGGAAGTGTA TACAGAGGAG 
GAGGAGGAGG AGTCCCAGGA GGAAGAGGAG GAAGAAGACA GTGACGAAGA GGAAAGAACA 
ATTGAAACTG CAAAAGGGAT TAATGGAACT GTAAATTATG ATAGTGTCAA TTCTGACAAC 
TCTAAGCCAA AGATATTTAA AAGTCAAATA GAGAACATAA ATTTGACCAA TGGCAGCAAT 
GGGAGGAACA CAGAGTCCCC AGCTGCCATT CACCCTTGTG GAAATCCTAC AGTGATTGAG 
GACGCTTTGG ACAAGATTAA AAGCAATGAC CCTGACACCA CAGAAGTCAA TTTGAACAAC 
ATTGAGAACA TCACAACACA GACCCTTACC CGCTTTGCTG AAGCCCTCAA GGACAACACT 
GTGGTGAAGA CGTTCAGTCT GGCCAACACG CATGCCGACG ACAGTGCAGC CATGGCCATT 
GCAGAGATGC TCAAAGTCAA TGAGCACATC ACCAACGTAA ACGTCGAGTC CAACTTCATA 
ACGGGAAAGG GGATCCTGGC CATCATGAGA GCTCTCCAGC ACAACACGGT GCTCACGGAG 
CTGCGTTTCC ATAACCAGAG GCACATCATG GGCAGCCAGG TGGAAATGGA GATTGTCAAG 
CTGCTGAAGG AGAACACGAC GCTGCTGAGG CTGGGATACC ATTTTGAACT CCCAGGACCA 
AGAATGAGCA TGACGAGCAT TTTGACAAGA AATATGGATA AACAGAGGCA AAAACGTTTG 
CAGGAGCAAA AACAGCAGGA GGGATACGAT GGAGGACCCA ATCTTAGGAC CAAAGTCTGG 
CAAAGAGGAA CACCTAGCTC TTCACCTTAT GTATCTCCCA GGCACTCACC CTGGTCATCC 
CCAAAACTCC CCAAAAAAGT CCAGACTGTG AGGAGCCGTC CTCTGTCTCC TGTGGCCACA 
CCTCCTCCTC CTCCCCCTCC TCCTCCTCCT CCCCCTCCTT CTTCCCAAAG GCTGCCACCA 
CCTCCTCCTC CTCCCCCTCC TCCACTCCCA GAGAAAAAGC TCATTACCAG AAACATTGCA 
GAAGTCATCA AACAACAGGA GAGTGCCCAA CGGGCATTAC AAAATGGACA AAAAAAGAAA 
AAAGGGAAAA AGGTCAAGAA ACAGCCAAAC AGTATTCTAA AGGAAATAAA AAATTCTCTG 
AGGTCAGTGC AAGAGAAGAA AATGGAAGAC AGTTCCCGAC CTTCTACCCC ACAGAGATCA 
GCTCATGAGA ATCTCATGGA AGCAATTCGG GGAAGCAGCA TAAAACAGCT AAAGCGGGTG 
GAAGTTCCAG AAGCCCTGCG ATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Crystal Structure of Leiomodin 2 in Complex with Actin: A Structural and Functional Reexamination.
Biophysical journal113(4)889-899(2017 Aug)
Boczkowska M,Yurtsever Z,Rebowski G,Eck MJ,Dominguez R

Localization of the binding interface between leiomodin-2 and ?-tropomyosin.
Biochimica et biophysica acta1864(5)523-30(2016 May)
Colpan M,Tolkatchev D,Grover S,Helms GL,Cort JR,Moroz N,Kostyukova AS

Mechanisms of leiomodin 2-mediated regulation of actin filament in muscle cells.
Proceedings of the National Academy of Sciences of the United States of America112(41)12687-92(2015 Oct)
Chen X,Ni F,Kondrashkina E,Ma J,Wang Q

How Leiomodin and Tropomodulin use a common fold for different actin assembly functions.
Nature communications68314(2015 Sep)
Boczkowska M,Rebowski G,Kremneva E,Lappalainen P,Dominguez R

Leiomodin-3 dysfunction results in thin filament disorganization and nemaline myopathy.
The Journal of clinical investigation124(11)4693-708(2014 Nov)
Yuen M,Sandaradura SA,Dowling JJ,Kostyukova AS,Moroz N,Quinlan KG,Lehtokari VL,Ravenscroft G,Todd EJ,Ceyhan-Birsoy O,Gokhin DS,Maluenda J,Lek M,Nolent F,Pappas CT,Novak SM,D'Amico A,Malfatti E,Thomas BP,Gabriel SB,Gupta N,Daly MJ,Ilkovski B,Houweling PJ,Davidson AE,Swanson LC,Brownstein CA,Gupta VA,Medne L,Shannon P,Martin N,Bick DP,Flisberg A,Holmberg E,Van den Bergh P,Lapunzina P,Waddell LB,Sloboda DD,Bertini E,Chitayat D,Telfer WR,Laquerri?re A,Gregorio CC,Ottenheijm CA,B?nnemann CG,Pelin K,Beggs AH,Hayashi YK,Romero NB,Laing NG,Nishino I,Wallgren-Pettersson C,Melki J,Fowler VM,MacArthur DG,North KN,Clarke NF

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LMOD2 cDNA ORF clone, Homo sapiens(human)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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