H2BC18 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	H2BC18
Entrez Gene ID	440689
Full Name	histone cluster 2 H2B family member f
General protein information	Preferred Names histone cluster 2 H2B family member f Names histone H2B type 2-F histone cluster 2, H2bf
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1q21.2
Summary	Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-dependent histone that is a member of the histone H2B family and is found in a histone cluster on chromosome 1. [provided by RefSeq, Aug 2015].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001024599.4	NP_001019770.1	histone H2B type 2-F isoform a
NM_001024599.5	NP_001019770.1	histone H2B type 2-F isoform a
NM_001161334.1	NP_001154806.1	histone H2B type 2-F isoform b

Pathways from BioSystems

Homologies

Homo sapiens (human)	HIST2H2BF	NP_001154806.1
Pan troglodytes (chimpanzee)	LOC457260	XP_003308398.1
Mus musculus (house mouse)	Hist2h2bb	NP_783597.2
	LOC704845	XP_001096522.2
Canis lupus familiaris (dog)	LOC608682	XP_005640186.1
Bos taurus (cattle)	LOC505183	XP_002697561.1
Rattus norvegicus (Norway rat)	LOC100912338	XP_006233057.1

Gene Ontology
Bibliography

Related articles in PubMed

Proteomic characterization of the human sperm nucleus.
de Mateo S, Castillo J, Estanyol JM, Ballesc? JL, Oliva R
Proteomics11(13)2714-26(2011 Jul)

MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
Buschow SI, van Balkom BW, Aalberts M, Heck AJ, Wauben M, Stoorvogel W
Immunology and cell biology88(8)851-6(2010 Nov-Dec)

Large-scale proteomics and phosphoproteomics of urinary exosomes.
Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal of the American Society of Nephrology : JASN20(2)363-79(2009 Feb)

Substrate and functional diversity of lysine acetylation revealed by a proteomics survey.
Kim SC, Sprung R, Chen Y, Xu Y, Ball H, Pei J, Cheng T, Kho Y, Xiao H, Xiao L, Grishin NV, White M, Yang XJ, Zhao Y
Molecular cell23(4)607-18(2006 Aug)

Histone H2B monoubiquitination functions cooperatively with FACT to regulate elongation by RNA polymerase II.
Pavri R, Zhu B, Li G, Trojer P, Mandal S, Shilatifard A, Reinberg D
Cell125(4)703-17(2006 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following H2BC18 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the H2BC18 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu10863	NM_001024599.5 Latest version!	Homo sapiens H2B clustered histone 18 (H2BC18), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu18655	NM_001161334.1 Latest version!	Homo sapiens H2B clustered histone 18 (H2BC18), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
View Old Accession Versions >>
OHu10863	NM_001024599.4	Homo sapiens histone cluster 2 H2B family member f (HIST2H2BF), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

H2BC18 ( NM_001024599.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_001019770.1 Homo sapiens histone cluster 2 H2B family member f (HIST2H2BF), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu10863
Clone ID Related Accession (Same CDS sequence)	NM_001024599.4 , NM_001024599.5
Accession Version	NM_001024599.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 381bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-22
Organism	Homo sapiens(human)
Product	histone H2B type 2-F isoform a
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC239868.2. On Jan 5, 2013 this sequence version replaced NM_001024599.3. Transcript Variant: This variant (1) differs in the 3' coding region and 3' UTR, compared to variant 2. The encoded isoform (a) has a shorter C-terminus compared to isoform b. ##Evidence-Data-START## Transcript is intronless :: DB195248.1, DA178178.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## replication-dependent histone :: PMID: 12408966 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCCGGATC CAGCGAAATC CGCTCCTGCT CCCAAGAAGG GCTCCAAAAA GGCTGTTACG 
AAAGTGCAGA AGAAGGACGG CAAGAAGCGC AAGCGCAGCC GCAAGGAGAG CTACTCCGTT 
TACGTGTACA AGGTGCTGAA GCAGGTCCAC CCCGACACCG GCATCTCGTC CAAGGCCATG 
GGCATCATGA ACTCCTTCGT CAACGACATC TTCGAGCGCA TCGCGGGAGA GGCGTCCCGC 
CTGGCGCACT ACAACAAGCG CTCCACCATC ACATCCCGCG AGATCCAGAC GGCCGTGCGC 
CTGCTGCTGC CCGGCGAGCT GGCCAAGCAC GCCGTGTCCG AGGGCACCAA GGCGGTCACC 
AAGTACACCA GCTCGAAGTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001019770.1
CDS	51..431
Translation	MPDPAKSAPAPKKGSKKAVTKVQKKDGKKRKRSRKESYSVYVYKVLKQVHPDTGISSKAMGIMNSFVNDIFERIAGEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVTKYTSSK

Target ORF information:

RefSeq Version	NM_001024599.4
Organism	Homo sapiens(human)
Definition	Homo sapiens histone cluster 2 H2B family member f (HIST2H2BF), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001024599.4

ORF Insert Sequence:

ATGCCGGATC CAGCGAAATC CGCTCCTGCT CCCAAGAAGG GCTCCAAAAA GGCTGTTACG 
AAAGTGCAGA AGAAGGACGG CAAGAAGCGC AAGCGCAGCC GCAAGGAGAG CTACTCCGTT 
TACGTGTACA AGGTGCTGAA GCAGGTCCAC CCCGACACCG GCATCTCGTC CAAGGCCATG 
GGCATCATGA ACTCCTTCGT CAACGACATC TTCGAGCGCA TCGCGGGAGA GGCGTCCCGC 
CTGGCGCACT ACAACAAGCG CTCCACCATC ACATCCCGCG AGATCCAGAC GGCCGTGCGC 
CTGCTGCTGC CCGGCGAGCT GGCCAAGCAC GCCGTGTCCG AGGGCACCAA GGCGGTCACC 
AAGTACACCA GCTCGAAGTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

H2BC18 ( NM_001024599.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_001019770.1 Homo sapiens H2B clustered histone 18 (H2BC18), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu10863
Clone ID Related Accession (Same CDS sequence)	NM_001024599.4 , NM_001024599.5
Accession Version	NM_001024599.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 381bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-02
Organism	Homo sapiens(human)
Product	histone H2B type 2-F isoform a
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC239868.2. On Dec 3, 2019 this sequence version replaced NM_001024599.4. Transcript Variant: This variant (1) differs in the 3' coding region and 3' UTR, compared to variant 2. The encoded isoform (a) has a shorter C-terminus compared to isoform b. ##Evidence-Data-START## Transcript is intronless :: AK289664.1, DB229053.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on manual assertion, conservation replication-dependent histone :: PMID: 12408966 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCCGGATC CAGCGAAATC CGCTCCTGCT CCCAAGAAGG GCTCCAAAAA GGCTGTTACG 
AAAGTGCAGA AGAAGGACGG CAAGAAGCGC AAGCGCAGCC GCAAGGAGAG CTACTCCGTT 
TACGTGTACA AGGTGCTGAA GCAGGTCCAC CCCGACACCG GCATCTCGTC CAAGGCCATG 
GGCATCATGA ACTCCTTCGT CAACGACATC TTCGAGCGCA TCGCGGGAGA GGCGTCCCGC 
CTGGCGCACT ACAACAAGCG CTCCACCATC ACATCCCGCG AGATCCAGAC GGCCGTGCGC 
CTGCTGCTGC CCGGCGAGCT GGCCAAGCAC GCCGTGTCCG AGGGCACCAA GGCGGTCACC 
AAGTACACCA GCTCGAAGTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001019770.1
CDS	48..428
Translation	MPDPAKSAPAPKKGSKKAVTKVQKKDGKKRKRSRKESYSVYVYKVLKQVHPDTGISSKAMGIMNSFVNDIFERIAGEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVTKYTSSK

Target ORF information:

RefSeq Version	NM_001024599.5
Organism	Homo sapiens(human)
Definition	Homo sapiens H2B clustered histone 18 (H2BC18), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001024599.5

ORF Insert Sequence:

ATGCCGGATC CAGCGAAATC CGCTCCTGCT CCCAAGAAGG GCTCCAAAAA GGCTGTTACG 
AAAGTGCAGA AGAAGGACGG CAAGAAGCGC AAGCGCAGCC GCAAGGAGAG CTACTCCGTT 
TACGTGTACA AGGTGCTGAA GCAGGTCCAC CCCGACACCG GCATCTCGTC CAAGGCCATG 
GGCATCATGA ACTCCTTCGT CAACGACATC TTCGAGCGCA TCGCGGGAGA GGCGTCCCGC 
CTGGCGCACT ACAACAAGCG CTCCACCATC ACATCCCGCG AGATCCAGAC GGCCGTGCGC 
CTGCTGCTGC CCGGCGAGCT GGCCAAGCAC GCCGTGTCCG AGGGCACCAA GGCGGTCACC 
AAGTACACCA GCTCGAAGTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

H2BC18 ( NM_001161334.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001154806.1 Homo sapiens H2B clustered histone 18 (H2BC18), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu18655
Clone ID Related Accession (Same CDS sequence)	NM_001161334.1
Accession Version	NM_001161334.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 405bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-02
Organism	Homo sapiens(human)
Product	histone H2B type 2-F isoform b
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA042901.1 and AK296916.1. This sequence is a reference standard in the RefSeqGene project. On or before Jul 8, 2009 this sequence version replaced XR_041011.1, XR_041012.2. Transcript Variant: This variant (2) encodes the longer isoform (b). ##Evidence-Data-START## Transcript exon combination :: AK296916.1, SRR1660805.208611.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2144120 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## replication-dependent histone :: PMID: 12408966 ##RefSeq-Attributes-END##

ATGCCGGATC CAGCGAAATC CGCTCCTGCT CCCAAGAAGG GCTCCAAAAA GGCTGTTACG 
AAAGTGCAGA AGAAGGACGG CAAGAAGCGC AAGCGCAGCC GCAAGGAGAG CTACTCCGTT 
TACGTGTACA AGGTGCTGAA GCAGGTCCAC CCCGACACCG GCATCTCGTC CAAGGCCATG 
GGCATCATGA ACTCCTTCGT CAACGACATC TTCGAGCGCA TCGCGGGAGA GGCGTCCCGC 
CTGGCGCACT ACAACAAGCG CTCCACCATC ACATCCCGCG AGATCCAGAC GGCCGTGCGC 
CTGCTGCTGC CCGGCGAGCT GGCCAAGCAC GCCGTGTCCG AGGGCACCAA GGCGGTCACC 
AAGTACACCA GCTCGAAGTT AATAGGACCC ATCCTTTGGA AGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001154806.1
CDS	51..455
Translation	MPDPAKSAPAPKKGSKKAVTKVQKKDGKKRKRSRKESYSVYVYKVLKQVHPDTGISSKAMGIMNSFVNDIFERIAGEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVTKYTSSKLIGPILWK

Target ORF information:

RefSeq Version	NM_001161334.1
Organism	Homo sapiens(human)
Definition	Homo sapiens H2B clustered histone 18 (H2BC18), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001161334.1

ORF Insert Sequence:

ATGCCGGATC CAGCGAAATC CGCTCCTGCT CCCAAGAAGG GCTCCAAAAA GGCTGTTACG 
AAAGTGCAGA AGAAGGACGG CAAGAAGCGC AAGCGCAGCC GCAAGGAGAG CTACTCCGTT 
TACGTGTACA AGGTGCTGAA GCAGGTCCAC CCCGACACCG GCATCTCGTC CAAGGCCATG 
GGCATCATGA ACTCCTTCGT CAACGACATC TTCGAGCGCA TCGCGGGAGA GGCGTCCCGC 
CTGGCGCACT ACAACAAGCG CTCCACCATC ACATCCCGCG AGATCCAGAC GGCCGTGCGC 
CTGCTGCTGC CCGGCGAGCT GGCCAAGCAC GCCGTGTCCG AGGGCACCAA GGCGGTCACC 
AAGTACACCA GCTCGAAGTT AATAGGACCC ATCCTTTGGA AGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Proteomic characterization of the human sperm nucleus.
Proteomics11(13)2714-26(2011 Jul)
de Mateo S,Castillo J,Estanyol JM,Ballesc? JL,Oliva R

MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
Immunology and cell biology88(8)851-6(2010 Nov-Dec)
Buschow SI,van Balkom BW,Aalberts M,Heck AJ,Wauben M,Stoorvogel W

Large-scale proteomics and phosphoproteomics of urinary exosomes.
Journal of the American Society of Nephrology : JASN20(2)363-79(2009 Feb)
Gonzales PA,Pisitkun T,Hoffert JD,Tchapyjnikov D,Star RA,Kleta R,Wang NS,Knepper MA

Substrate and functional diversity of lysine acetylation revealed by a proteomics survey.
Molecular cell23(4)607-18(2006 Aug)
Kim SC,Sprung R,Chen Y,Xu Y,Ball H,Pei J,Cheng T,Kho Y,Xiao H,Xiao L,Grishin NV,White M,Yang XJ,Zhao Y

Histone H2B monoubiquitination functions cooperatively with FACT to regulate elongation by RNA polymerase II.
Cell125(4)703-17(2006 May)
Pavri R,Zhu B,Li G,Trojer P,Mandal S,Shilatifard A,Reinberg D

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H2BC18 cDNA ORF clone, Homo sapiens(human)

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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