MOCS2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	MOCS2
Entrez Gene ID	4338
Full Name	molybdenum cofactor synthesis 2
Synonyms	MCBPE,MOCO1,MOCODB,MPTS
General protein information	Preferred Names molybdenum cofactor synthesis 2 Names molybdopterin synthase catalytic subunit molybdopterin synthase sulfur carrier subunit molybdenum cofactor biosynthesis protein E
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 5 Map Location: 5q11.2
Summary	Eukaryotic molybdoenzymes use a unique molybdenum cofactor (MoCo) consisting of a pterin, termed molybdopterin, and the catalytically active metal molybdenum. MoCo is synthesized from precursor Z by the heterodimeric enzyme molybdopterin synthase. The large and small subunits of molybdopterin synthase are both encoded from this gene by overlapping open reading frames. The proteins were initially thought to be encoded from a bicistronic transcript. They are now thought to be encoded from monocistronic transcripts. Alternatively spliced transcripts have been found for this locus that encode the large and small subunits. [provided by RefSeq, Jul 2008].
Disorder MIM:	603708
Disorder Html:	Molybdenum cofactor deficiency B, 252160 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_176806.3	NP_789776.1	molybdopterin synthase sulfur carrier subunit small subunit MOCS2A
NM_176806.4	NP_789776.1	molybdopterin synthase sulfur carrier subunit small subunit MOCS2A
NM_004531.4	NP_004522.1	molybdopterin synthase catalytic subunit large subunit MOCS2B
NM_004531.5	NP_004522.1	molybdopterin synthase catalytic subunit large subunit MOCS2B

Pathways from BioSystems

Homologies

	MOCS2	XP_001095584.1
Canis lupus familiaris (dog)	MOCS2	XP_005619387.1
Bos taurus (cattle)	MOCS2	NP_001014867.1
Arabidopsis thaliana (thale cress)	AT2G43760	NP_001078051.1
Magnaporthe oryzae (rice blast fungus)	MGG_17889	XP_003720671.1
Neurospora crassa	NCU03170	XP_964576.1
Oryza sativa (rice)	Os02g0140300	NP_001045852.1
Pan troglodytes (chimpanzee)	MOCS2	XP_001149868.1
Drosophila melanogaster (fruit fly)	Mocs2	NP_651340.1
Caenorhabditis elegans (roundworm)	T27A3.6	NP_491763.1
Homo sapiens (human)	MOCS2	NP_004522.1
Mus musculus (house mouse)	Mocs2	NP_001106845.1
Rattus norvegicus (Norway rat)	Mocs2	NP_001007634.1
Gallus gallus (chicken)	MOCS2	XP_003642989.1
Anopheles gambiae (African malaria mosquito)	MOC2B_ANOGA	XP_003436776.1
Danio rerio (zebrafish)	mocs2	XP_001338032.3
Xenopus tropicalis (tropical clawed frog)	mocs2	XP_002933074.2

Gene Ontology
Bibliography

Related articles in PubMed

Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.
Navarini AA, Simpson MA, Weale M, Knight J, Carlavan I, Reiniche P, Burden DA, Layton A, Bataille V, Allen M, Pleass R, Pink A, Creamer D, English J, Munn S, Walton S, , Willis C, D?ret S, Voegel JJ, Spector T, Smith CH, Trembath RC, Barker JN
Nature communications54020(2014 Jun)

A novel role for human Nfs1 in the cytoplasm: Nfs1 acts as a sulfur donor for MOCS3, a protein involved in molybdenum cofactor biosynthesis.
Marelja Z, St?cklein W, Nimtz M, Leimk?hler S
The Journal of biological chemistry283(37)25178-85(2008 Sep)

Molybdenum cofactor deficiency: clinical features in a Turkish patient.
Per H, G?m?? H, Ichida K, Ca?layan O, Kumanda? S
Brain & development29(6)365-8(2007 Jul)

A novel MOCS2 mutation reveals coordinated expression of the small and large subunit of molybdopterin synthase.
Hahnewald R, Leimk?hler S, Vilaseca A, Acquaviva-Bourdain C, Lenz U, Reiss J
Molecular genetics and metabolism89(3)210-3(2006 Nov)

A probability-based approach for high-throughput protein phosphorylation analysis and site localization.
Beausoleil SA, Vill?n J, Gerber SA, Rush J, Gygi SP
Nature biotechnology24(10)1285-92(2006 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

We reported here an infant with MoCD who presented with hypoxic ischaemic encephalopathy and identified a novel mutation, c.130C>T in cDNA of the MOCS2 gene from the infant.
Title: Molybdenum cofactor deficiency: clinical features in a Turkish patient.

There was undisturbed production of both transcripts, while Western blot analysis demonstrated that MOCS2B, the large subunit, is unstable in the absence of MOCS2A.
Title: A novel MOCS2 mutation reveals coordinated expression of the small and large subunit of molybdopterin synthase.

analysis of sites within MOCS2 where mutations cause molybdenum cofactor deficiency
Title: Mechanistic studies of human molybdopterin synthase reaction and characterization of mutants identified in group B patients of molybdenum cofactor deficiency.

Review: A total of 32 different disease-causing mutations, including several common to more than one family, have been identified in molybdenum cofactor-deficient patients and their relatives
Title: Mutations in the molybdenum cofactor biosynthetic genes MOCS1, MOCS2, and GEPH.

The following MOCS2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MOCS2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu21230	NM_176806.4 Latest version!	Homo sapiens molybdenum cofactor synthesis 2 (MOCS2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu21839	NM_004531.5 Latest version!	Homo sapiens molybdenum cofactor synthesis 2 (MOCS2), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu21230	NM_176806.3	Homo sapiens molybdenum cofactor synthesis 2 (MOCS2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu21839	NM_004531.4	Homo sapiens molybdenum cofactor synthesis 2 (MOCS2), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

MOCS2 ( NM_176806.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_789776.1 Homo sapiens molybdenum cofactor synthesis 2 (MOCS2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu21230
Clone ID Related Accession (Same CDS sequence)	NM_176806.3 , NM_176806.4
Accession Version	NM_176806.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 267bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-06-24
Organism	Homo sapiens(human)
Product	molybdopterin synthase sulfur carrier subunit small subunit MOCS2A
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC095417.1, AC008966.9 and CB050849.1. This sequence is a reference standard in the RefSeqGene project. On Jul 2, 2013 this sequence version replaced NM_176806.2. Transcript Variant: This variant (1) has an alternate splice site in the 5' region, as compared to variant 3. This variant encodes the small subunit MOCS2A, also called MOCO1-A, which is derived from the upstream ORF and is supported by PMID 16737835. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. CCDS Note: This CCDS ID represents the protein described in PMIDs: 10053003, 16737835 and 9889283. This transcript is supported by BC095417.1. It should be noted this transcript is predicted to undergo nonsense-mediated mRNA decay (NMD). However, the protein is represented because it was detected endogenously in PMID: 10053003 and 16737835. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803616.96440.1, SRR1803614.30707.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2155550 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## NMD candidate :: PMID: 16737835 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGTGCCGC TGTGCCAGGT TGAAGTATTG TATTTTGCAA AAAGTGCTGA AATAACAGGA 
GTTCGTTCAG AGACCATTTC TGTGCCTCAA GAAATAAAAG CGTTGCAGCT GTGGAAGGAG 
ATAGAAACTC GACATCCTGG ATTGGCTGAT GTTAGAAATC AGATAATATT TGCTGTTCGT 
CAAGAATATG TCGAGCTTGG AGATCAGCTC CTCGTGCTTC AGCCTGGAGA CGAAATTGCC 
GTTATCCCCC CCATTAGTGG AGGATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_789776.1
CDS	44..310
Translation	MVPLCQVEVLYFAKSAEITGVRSETISVPQEIKALQLWKEIETRHPGLADVRNQIIFAVRQEYVELGDQLLVLQPGDEIAVIPPISGG

Target ORF information:

RefSeq Version	NM_176806.3
Organism	Homo sapiens(human)
Definition	Homo sapiens molybdenum cofactor synthesis 2 (MOCS2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_176806.3

ORF Insert Sequence:

ATGGTGCCGC TGTGCCAGGT TGAAGTATTG TATTTTGCAA AAAGTGCTGA AATAACAGGA 
GTTCGTTCAG AGACCATTTC TGTGCCTCAA GAAATAAAAG CGTTGCAGCT GTGGAAGGAG 
ATAGAAACTC GACATCCTGG ATTGGCTGAT GTTAGAAATC AGATAATATT TGCTGTTCGT 
CAAGAATATG TCGAGCTTGG AGATCAGCTC CTCGTGCTTC AGCCTGGAGA CGAAATTGCC 
GTTATCCCCC CCATTAGTGG AGGATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MOCS2 ( NM_176806.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_789776.1 Homo sapiens molybdenum cofactor synthesis 2 (MOCS2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu21230
Clone ID Related Accession (Same CDS sequence)	NM_176806.3 , NM_176806.4
Accession Version	NM_176806.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 267bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-21
Organism	Homo sapiens(human)
Product	molybdopterin synthase sulfur carrier subunit small subunit MOCS2A
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC095417.1, AC008966.9 and CB050849.1. This sequence is a reference standard in the RefSeqGene project. On May 31, 2019 this sequence version replaced NM_176806.3. Transcript Variant: This variant (1) has an alternate splice site in the 5' region, as compared to variant 3. This variant encodes the small subunit MOCS2A, also called MOCO1-A, which is derived from the upstream ORF and is supported by PMID 16737835. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. CCDS Note: This CCDS ID represents the protein described in PMIDs: 10053003, 16737835 and 9889283. This transcript is supported by BC095417.1. It should be noted this transcript is predicted to undergo nonsense-mediated mRNA decay (NMD). However, the protein is represented because it was detected endogenously in PMID: 10053003 and 16737835. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660809.212050.1, SRR1803612.23549.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2155550 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## NMD candidate :: PMID: 16737835 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGTGCCGC TGTGCCAGGT TGAAGTATTG TATTTTGCAA AAAGTGCTGA AATAACAGGA 
GTTCGTTCAG AGACCATTTC TGTGCCTCAA GAAATAAAAG CGTTGCAGCT GTGGAAGGAG 
ATAGAAACTC GACATCCTGG ATTGGCTGAT GTTAGAAATC AGATAATATT TGCTGTTCGT 
CAAGAATATG TCGAGCTTGG AGATCAGCTC CTCGTGCTTC AGCCTGGAGA CGAAATTGCC 
GTTATCCCCC CCATTAGTGG AGGATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_789776.1
CDS	29..295
Translation	MVPLCQVEVLYFAKSAEITGVRSETISVPQEIKALQLWKEIETRHPGLADVRNQIIFAVRQEYVELGDQLLVLQPGDEIAVIPPISGG

Target ORF information:

RefSeq Version	NM_176806.4
Organism	Homo sapiens(human)
Definition	Homo sapiens molybdenum cofactor synthesis 2 (MOCS2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_176806.4

ORF Insert Sequence:

ATGGTGCCGC TGTGCCAGGT TGAAGTATTG TATTTTGCAA AAAGTGCTGA AATAACAGGA 
GTTCGTTCAG AGACCATTTC TGTGCCTCAA GAAATAAAAG CGTTGCAGCT GTGGAAGGAG 
ATAGAAACTC GACATCCTGG ATTGGCTGAT GTTAGAAATC AGATAATATT TGCTGTTCGT 
CAAGAATATG TCGAGCTTGG AGATCAGCTC CTCGTGCTTC AGCCTGGAGA CGAAATTGCC 
GTTATCCCCC CCATTAGTGG AGGATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MOCS2 ( NM_004531.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_004522.1 Homo sapiens molybdenum cofactor synthesis 2 (MOCS2), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu21839
Clone ID Related Accession (Same CDS sequence)	NM_004531.4 , NM_004531.5
Accession Version	NM_004531.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 567bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-02
Organism	Homo sapiens(human)
Product	molybdopterin synthase catalytic subunit large subunit MOCS2B
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC095417.1, DA967651.1, BC046097.1, AC008966.9 and CB050849.1. This sequence is a reference standard in the RefSeqGene project. On Jul 2, 2013 this sequence version replaced NM_004531.3. Transcript Variant: This variant (3) encodes the large subunit MOCS2B, also called MOCO1-B. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660807.92737.1, SRR1660805.212585.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2155550 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCGAGCT TGGAGATCAG CTCCTCGTGC TTCAGCCTGG AGACGAAATT GCCGTTATCC 
CCCCCATTAG TGGAGGATAG TGCTTTTGAG CCATCTAGGA AAGATATGGA TGAAGTTGAA 
GAGAAATCTA AAGATGTTAT AAACTTTACT GCCGAGAAAC TTTCAGTAGA TGAAGTCTCA 
CAGTTGGTGA TTTCTCCGCT CTGTGGTGCA ATATCCCTAT TTGTAGGGAC TACAAGAAAT 
AACTTTGAAG GGAAAAAAGT CATTAGCTTA GAATATGAAG CATATCTACC CATGGCGGAA 
AATGAAGTCA GAAAGATTTG TAGTGACATT AGGCAGAAAT GGCCAGTCAA ACACATAGCA 
GTGTTCCATA GACTTGGCTT GGTTCCAGTG TCAGAAGCAA GCATAATCAT TGCTGTGTCC 
TCAGCCCACA GAGCTGCATC TCTTGAAGCT GTGAGCTATG CCATTGATAC TTTAAAAGCC 
AAGGTGCCCA TATGGAAAAA GGAAATATAC GAAGAGTCAT CAACTTGGAA AGGAAACAAA 
GAGTGCTTTT GGGCATCCAA CAGTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004522.1
CDS	692..1258
Translation	MSSLEISSSCFSLETKLPLSPPLVEDSAFEPSRKDMDEVEEKSKDVINFTAEKLSVDEVSQLVISPLCGAISLFVGTTRNNFEGKKVISLEYEAYLPMAENEVRKICSDIRQKWPVKHIAVFHRLGLVPVSEASIIIAVSSAHRAASLEAVSYAIDTLKAKVPIWKKEIYEESSTWKGNKECFWASNS

Target ORF information:

RefSeq Version	NM_004531.4
Organism	Homo sapiens(human)
Definition	Homo sapiens molybdenum cofactor synthesis 2 (MOCS2), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004531.4

ORF Insert Sequence:

ATGTCGAGCT TGGAGATCAG CTCCTCGTGC TTCAGCCTGG AGACGAAATT GCCGTTATCC 
CCCCCATTAG TGGAGGATAG TGCTTTTGAG CCATCTAGGA AAGATATGGA TGAAGTTGAA 
GAGAAATCTA AAGATGTTAT AAACTTTACT GCCGAGAAAC TTTCAGTAGA TGAAGTCTCA 
CAGTTGGTGA TTTCTCCGCT CTGTGGTGCA ATATCCCTAT TTGTAGGGAC TACAAGAAAT 
AACTTTGAAG GGAAAAAAGT CATTAGCTTA GAATATGAAG CATATCTACC CATGGCGGAA 
AATGAAGTCA GAAAGATTTG TAGTGACATT AGGCAGAAAT GGCCAGTCAA ACACATAGCA 
GTGTTCCATA GACTTGGCTT GGTTCCAGTG TCAGAAGCAA GCATAATCAT TGCTGTGTCC 
TCAGCCCACA GAGCTGCATC TCTTGAAGCT GTGAGCTATG CCATTGATAC TTTAAAAGCC 
AAGGTGCCCA TATGGAAAAA GGAAATATAC GAAGAGTCAT CAACTTGGAA AGGAAACAAA 
GAGTGCTTTT GGGCATCCAA CAGTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MOCS2 ( NM_004531.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_004522.1 Homo sapiens molybdenum cofactor synthesis 2 (MOCS2), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu21839
Clone ID Related Accession (Same CDS sequence)	NM_004531.4 , NM_004531.5
Accession Version	NM_004531.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 567bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-21
Organism	Homo sapiens(human)
Product	molybdopterin synthase catalytic subunit large subunit MOCS2B
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC095417.1, DA967651.1, BC046097.1, AC008966.9 and CB050849.1. This sequence is a reference standard in the RefSeqGene project. On Nov 23, 2018 this sequence version replaced NM_004531.4. Transcript Variant: This variant (3) encodes the large subunit MOCS2B, also called MOCO1-B. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660807.92737.1, SRR1660805.212585.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2155550 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000396954.8/ ENSP00000380157.3 RefSeq Select criteria :: based on conservation, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGTCGAGCT TGGAGATCAG CTCCTCGTGC TTCAGCCTGG AGACGAAATT GCCGTTATCC 
CCCCCATTAG TGGAGGATAG TGCTTTTGAG CCATCTAGGA AAGATATGGA TGAAGTTGAA 
GAGAAATCTA AAGATGTTAT AAACTTTACT GCCGAGAAAC TTTCAGTAGA TGAAGTCTCA 
CAGTTGGTGA TTTCTCCGCT CTGTGGTGCA ATATCCCTAT TTGTAGGGAC TACAAGAAAT 
AACTTTGAAG GGAAAAAAGT CATTAGCTTA GAATATGAAG CATATCTACC CATGGCGGAA 
AATGAAGTCA GAAAGATTTG TAGTGACATT AGGCAGAAAT GGCCAGTCAA ACACATAGCA 
GTGTTCCATA GACTTGGCTT GGTTCCAGTG TCAGAAGCAA GCATAATCAT TGCTGTGTCC 
TCAGCCCACA GAGCTGCATC TCTTGAAGCT GTGAGCTATG CCATTGATAC TTTAAAAGCC 
AAGGTGCCCA TATGGAAAAA GGAAATATAC GAAGAGTCAT CAACTTGGAA AGGAAACAAA 
GAGTGCTTTT GGGCATCCAA CAGTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004522.1
CDS	677..1243
Translation	MSSLEISSSCFSLETKLPLSPPLVEDSAFEPSRKDMDEVEEKSKDVINFTAEKLSVDEVSQLVISPLCGAISLFVGTTRNNFEGKKVISLEYEAYLPMAENEVRKICSDIRQKWPVKHIAVFHRLGLVPVSEASIIIAVSSAHRAASLEAVSYAIDTLKAKVPIWKKEIYEESSTWKGNKECFWASNS

Target ORF information:

RefSeq Version	NM_004531.5
Organism	Homo sapiens(human)
Definition	Homo sapiens molybdenum cofactor synthesis 2 (MOCS2), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004531.5

ORF Insert Sequence:

ATGTCGAGCT TGGAGATCAG CTCCTCGTGC TTCAGCCTGG AGACGAAATT GCCGTTATCC 
CCCCCATTAG TGGAGGATAG TGCTTTTGAG CCATCTAGGA AAGATATGGA TGAAGTTGAA 
GAGAAATCTA AAGATGTTAT AAACTTTACT GCCGAGAAAC TTTCAGTAGA TGAAGTCTCA 
CAGTTGGTGA TTTCTCCGCT CTGTGGTGCA ATATCCCTAT TTGTAGGGAC TACAAGAAAT 
AACTTTGAAG GGAAAAAAGT CATTAGCTTA GAATATGAAG CATATCTACC CATGGCGGAA 
AATGAAGTCA GAAAGATTTG TAGTGACATT AGGCAGAAAT GGCCAGTCAA ACACATAGCA 
GTGTTCCATA GACTTGGCTT GGTTCCAGTG TCAGAAGCAA GCATAATCAT TGCTGTGTCC 
TCAGCCCACA GAGCTGCATC TCTTGAAGCT GTGAGCTATG CCATTGATAC TTTAAAAGCC 
AAGGTGCCCA TATGGAAAAA GGAAATATAC GAAGAGTCAT CAACTTGGAA AGGAAACAAA 
GAGTGCTTTT GGGCATCCAA CAGTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.
Nature communications54020(2014 Jun)
Navarini AA,Simpson MA,Weale M,Knight J,Carlavan I,Reiniche P,Burden DA,Layton A,Bataille V,Allen M,Pleass R,Pink A,Creamer D,English J,Munn S,Walton S,,Willis C,D?ret S,Voegel JJ,Spector T,Smith CH,Trembath RC,Barker JN

A novel role for human Nfs1 in the cytoplasm: Nfs1 acts as a sulfur donor for MOCS3, a protein involved in molybdenum cofactor biosynthesis.
The Journal of biological chemistry283(37)25178-85(2008 Sep)
Marelja Z,St?cklein W,Nimtz M,Leimk?hler S

Molybdenum cofactor deficiency: clinical features in a Turkish patient.
Brain & development29(6)365-8(2007 Jul)
Per H,G?m?? H,Ichida K,Ca?layan O,Kumanda? S

A novel MOCS2 mutation reveals coordinated expression of the small and large subunit of molybdopterin synthase.
Molecular genetics and metabolism89(3)210-3(2006 Nov)
Hahnewald R,Leimk?hler S,Vilaseca A,Acquaviva-Bourdain C,Lenz U,Reiss J

A probability-based approach for high-throughput protein phosphorylation analysis and site localization.
Nature biotechnology24(10)1285-92(2006 Oct)
Beausoleil SA,Vill?n J,Gerber SA,Rush J,Gygi SP

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MOCS2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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