SLURP2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	SLURP2
Entrez Gene ID	432355
Full Name	secreted LY6/PLAUR domain containing 2
Synonyms	SLURP-2
General protein information	Preferred Names secreted LY6/PLAUR domain containing 2 Names secreted Ly-6/uPAR domain-containing protein 2 secreted LY6/PLAUR domain-containing protein 2 secreted Ly-6/uPAR-related protein 2 secreted Ly6/uPAR related protein 2
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 8 Map Location: 8q24.3
Summary	This gene encodes a novel, secreted member of the Ly6/uPAR (LU) superfamily of proteins containing the unique three-finger LU domain. This gene is mainly expressed in epithelial cells, including skin and keratinocytes, and is up-regulated in psoriatic skin lesions, suggesting its involvement in the pathophysiology of psoriasis. Alternatively spliced transcript variants have been found for this gene. Read-through transcription from the neighboring upstream gene (LYNX1) generates naturally-occurring transcripts (LYNX1-SLURP2) that encode a fusion protein comprised of sequence sharing identity with each individual gene product. [provided by RefSeq, Sep 2017].

mRNA and Protein(s)

mRNA	Protein	Name
NM_177458.2	NP_803253.1	secreted Ly-6/uPAR domain-containing protein 2 isoform 1 precursor
NM_001356372.1	NP_001343301.1	secreted Ly-6/uPAR domain-containing protein 2 isoform 2 precursor
NM_001356372.2	NP_001343301.1	secreted Ly-6/uPAR domain-containing protein 2 isoform 2 precursor
NM_177458.3	NP_803253.1	secreted Ly-6/uPAR domain-containing protein 2 isoform 1 precursor

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

Secreted Isoform of Human Lynx1 (SLURP-2): Spatial Structure and Pharmacology of Interactions with Different Types of Acetylcholine Receptors.
Lyukmanova EN, Shulepko MA, Shenkarev ZO, Bychkov ML, Paramonov AS, Chugunov AO, Kulbatskii DS, Arvaniti M, Dolejsi E, Schaer T, Arseniev AS, Efremov RG, Thomsen MS, Dolezal V, Bertrand D, Dolgikh DA, Kirpichnikov MP
Scientific reports630698(2016 Aug)

Organization, evolution and functions of the human and mouse Ly6/uPAR family genes.
Loughner CL, Bruford EA, McAndrews MS, Delp EE, Swamynathan S, Swamynathan SK
Human genomics1010(2016 Apr)

Transcriptional regulation of SLURP2, a psoriasis-associated gene, is under control of IL-22 in the skin: A special reference to the nested gene LYNX1.
Moriwaki Y, Takada K, Tsuji S, Kawashima K, Misawa H
International immunopharmacology29(1)71-5(2015 Nov)

Anti-inflammatory effects of the nicotinergic peptides SLURP-1 and SLURP-2 on human intestinal epithelial cells and immunocytes.
Chernyavsky AI, Galitovskiy V, Shchepotin IB, Grando SA
BioMed research international2014609086(2014)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following SLURP2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SLURP2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu07444	NM_177458.3 Latest version!	Homo sapiens secreted LY6/PLAUR domain containing 2 (SLURP2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu103221	NM_001356372.2 Latest version!	Homo sapiens secreted LY6/PLAUR domain containing 2 (SLURP2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
View Old Accession Versions >>
OHu103221	NM_001356372.1	Homo sapiens secreted LY6/PLAUR domain containing 2 (SLURP2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
OHu07444	NM_177458.2	Homo sapiens secreted LY6/PLAUR domain containing 2 (SLURP2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

SLURP2 ( NM_177458.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_803253.1 Homo sapiens secreted LY6/PLAUR domain containing 2 (SLURP2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu07444
Clone ID Related Accession (Same CDS sequence)	NM_177458.2 , NM_177458.3
Accession Version	NM_177458.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 294bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	secreted Ly-6/uPAR domain-containing protein 2 isoform 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AB081838.1, AC083841.9 and AY358417.1. On Sep 29, 2017 this sequence version replaced NM_177458.1. Transcript Variant: This variant (1) represents the predominant transcript and encodes the longer isoform (1). COMPLETENESS: full length.

ATGCAGCTCG GCACTGGGCT CCTGCTGGCC GCCGTCCTGA GCCTGCAGCT GGCTGCAGCC 
GAAGCCATAT GGTGTCACCA GTGCACGGGC TTCGGAGGGT GCTCCCATGG ATCCAGATGC 
CTGAGGGACT CCACCCACTG TGTCACCACT GCCACCCGGG TCCTCAGCAA CACCGAGGAT 
TTGCCTCTGG TCACCAAGAT GTGCCACATA GGCTGCCCCG ATATCCCCAG CCTGGGCCTG 
GGCCCCTACG TATCCATCGC TTGCTGCCAG ACCAGCCTCT GCAACCATGA CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_803253.1
CDS	23..316
Translation	MQLGTGLLLAAVLSLQLAAAEAIWCHQCTGFGGCSHGSRCLRDSTHCVTTATRVLSNTEDLPLVTKMCHIGCPDIPSLGLGPYVSIACCQTSLCNHD

Target ORF information:

RefSeq Version	NM_177458.2
Organism	Homo sapiens(human)
Definition	Homo sapiens secreted LY6/PLAUR domain containing 2 (SLURP2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_177458.2

ORF Insert Sequence:

ATGCAGCTCG GCACTGGGCT CCTGCTGGCC GCCGTCCTGA GCCTGCAGCT GGCTGCAGCC 
GAAGCCATAT GGTGTCACCA GTGCACGGGC TTCGGAGGGT GCTCCCATGG ATCCAGATGC 
CTGAGGGACT CCACCCACTG TGTCACCACT GCCACCCGGG TCCTCAGCAA CACCGAGGAT 
TTGCCTCTGG TCACCAAGAT GTGCCACATA GGCTGCCCCG ATATCCCCAG CCTGGGCCTG 
GGCCCCTACG TATCCATCGC TTGCTGCCAG ACCAGCCTCT GCAACCATGA CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SLURP2 ( NM_177458.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_803253.1 Homo sapiens secreted LY6/PLAUR domain containing 2 (SLURP2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu07444
Clone ID Related Accession (Same CDS sequence)	NM_177458.2 , NM_177458.3
Accession Version	NM_177458.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 294bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-26
Organism	Homo sapiens(human)
Product	secreted Ly-6/uPAR domain-containing protein 2 isoform 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AB081838.1, AC083841.9 and AY358417.1. On Nov 23, 2018 this sequence version replaced NM_177458.2. Transcript Variant: This variant (1) represents the predominant transcript and encodes the longer isoform (1). ##Evidence-Data-START## Transcript exon combination :: AB081838.1, AY358417.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145893, SAMEA2147975 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000317543.12/ ENSP00000319846.7 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCAGCTCG GCACTGGGCT CCTGCTGGCC GCCGTCCTGA GCCTGCAGCT GGCTGCAGCC 
GAAGCCATAT GGTGTCACCA GTGCACGGGC TTCGGAGGGT GCTCCCATGG ATCCAGATGC 
CTGAGGGACT CCACCCACTG TGTCACCACT GCCACCCGGG TCCTCAGCAA CACCGAGGAT 
TTGCCTCTGG TCACCAAGAT GTGCCACATA GGCTGCCCCG ATATCCCCAG CCTGGGCCTG 
GGCCCCTACG TATCCATCGC TTGCTGCCAG ACCAGCCTCT GCAACCATGA CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_803253.1
CDS	23..316
Translation	MQLGTGLLLAAVLSLQLAAAEAIWCHQCTGFGGCSHGSRCLRDSTHCVTTATRVLSNTEDLPLVTKMCHIGCPDIPSLGLGPYVSIACCQTSLCNHD

Target ORF information:

RefSeq Version	NM_177458.3
Organism	Homo sapiens(human)
Definition	Homo sapiens secreted LY6/PLAUR domain containing 2 (SLURP2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_177458.3

ORF Insert Sequence:

ATGCAGCTCG GCACTGGGCT CCTGCTGGCC GCCGTCCTGA GCCTGCAGCT GGCTGCAGCC 
GAAGCCATAT GGTGTCACCA GTGCACGGGC TTCGGAGGGT GCTCCCATGG ATCCAGATGC 
CTGAGGGACT CCACCCACTG TGTCACCACT GCCACCCGGG TCCTCAGCAA CACCGAGGAT 
TTGCCTCTGG TCACCAAGAT GTGCCACATA GGCTGCCCCG ATATCCCCAG CCTGGGCCTG 
GGCCCCTACG TATCCATCGC TTGCTGCCAG ACCAGCCTCT GCAACCATGA CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SLURP2 ( NM_001356372.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001343301.1 Homo sapiens secreted LY6/PLAUR domain containing 2 (SLURP2), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu103221
Clone ID Related Accession (Same CDS sequence)	NM_001356372.1 , NM_001356372.2
Accession Version	NM_001356372.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 285bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-12-05
Organism	Homo sapiens(human)
Product	secreted Ly-6/uPAR domain-containing protein 2 isoform 2 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AB081838.1, AC083841.9 and AY358417.1. Transcript Variant: This variant (2) uses an alternate acceptor splice site at the 3' terminal exon, which causes a frameshift compared to variant 1. The resulting shorter isoform (2) has a distinct C-terminus compared to isoform 1. ##Evidence-Data-START## Transcript exon combination :: AW117934.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145893, SAMEA2147975 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

ATGCAGCTCG GCACTGGGCT CCTGCTGGCC GCCGTCCTGA GCCTGCAGCT GGCTGCAGCC 
GAAGCCATAT GGTGTCACCA GTGCACGGGC TTCGGAGGGT GCTCCCATGG ATCCAGATGC 
CTGAGGGACT CCACCCACTG TGTCACCACT GCCACCCGCC CCCGGACGCT CAGCCCCCAC 
AGCCCCCACA GCCTGGCGCC AGGGCTCACA GCTGCCCCTC CCTCGAGACT GGCCAGCCCA 
CCTCTCCCGG CCTCTGCAGC CACCGTCCAG CACCGCTTGT CCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001343301.1
CDS	23..307
Translation	MQLGTGLLLAAVLSLQLAAAEAIWCHQCTGFGGCSHGSRCLRDSTHCVTTATRPRTLSPHSPHSLAPGLTAAPPSRLASPPLPASAATVQHRLS

Target ORF information:

RefSeq Version	NM_001356372.1
Organism	Homo sapiens(human)
Definition	Homo sapiens secreted LY6/PLAUR domain containing 2 (SLURP2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001356372.1

ORF Insert Sequence:

ATGCAGCTCG GCACTGGGCT CCTGCTGGCC GCCGTCCTGA GCCTGCAGCT GGCTGCAGCC 
GAAGCCATAT GGTGTCACCA GTGCACGGGC TTCGGAGGGT GCTCCCATGG ATCCAGATGC 
CTGAGGGACT CCACCCACTG TGTCACCACT GCCACCCGCC CCCGGACGCT CAGCCCCCAC 
AGCCCCCACA GCCTGGCGCC AGGGCTCACA GCTGCCCCTC CCTCGAGACT GGCCAGCCCA 
CCTCTCCCGG CCTCTGCAGC CACCGTCCAG CACCGCTTGT CCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SLURP2 ( NM_001356372.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001343301.1 Homo sapiens secreted LY6/PLAUR domain containing 2 (SLURP2), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu103221
Clone ID Related Accession (Same CDS sequence)	NM_001356372.1 , NM_001356372.2
Accession Version	NM_001356372.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 285bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-27
Organism	Homo sapiens(human)
Product	secreted Ly-6/uPAR domain-containing protein 2 isoform 2 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AB081838.1, AC083841.9 and AY358417.1. On May 31, 2019 this sequence version replaced NM_001356372.1. Transcript Variant: This variant (2) uses an alternate acceptor splice site at the 3' terminal exon, which causes a frameshift compared to variant 1. The resulting shorter isoform (2) has a distinct C-terminus compared to isoform 1. ##Evidence-Data-START## Transcript exon combination :: AW117934.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145893, SAMEA2147975 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

ATGCAGCTCG GCACTGGGCT CCTGCTGGCC GCCGTCCTGA GCCTGCAGCT GGCTGCAGCC 
GAAGCCATAT GGTGTCACCA GTGCACGGGC TTCGGAGGGT GCTCCCATGG ATCCAGATGC 
CTGAGGGACT CCACCCACTG TGTCACCACT GCCACCCGCC CCCGGACGCT CAGCCCCCAC 
AGCCCCCACA GCCTGGCGCC AGGGCTCACA GCTGCCCCTC CCTCGAGACT GGCCAGCCCA 
CCTCTCCCGG CCTCTGCAGC CACCGTCCAG CACCGCTTGT CCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001343301.1
CDS	23..307
Translation	MQLGTGLLLAAVLSLQLAAAEAIWCHQCTGFGGCSHGSRCLRDSTHCVTTATRPRTLSPHSPHSLAPGLTAAPPSRLASPPLPASAATVQHRLS

Target ORF information:

RefSeq Version	NM_001356372.2
Organism	Homo sapiens(human)
Definition	Homo sapiens secreted LY6/PLAUR domain containing 2 (SLURP2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001356372.2

ORF Insert Sequence:

ATGCAGCTCG GCACTGGGCT CCTGCTGGCC GCCGTCCTGA GCCTGCAGCT GGCTGCAGCC 
GAAGCCATAT GGTGTCACCA GTGCACGGGC TTCGGAGGGT GCTCCCATGG ATCCAGATGC 
CTGAGGGACT CCACCCACTG TGTCACCACT GCCACCCGCC CCCGGACGCT CAGCCCCCAC 
AGCCCCCACA GCCTGGCGCC AGGGCTCACA GCTGCCCCTC CCTCGAGACT GGCCAGCCCA 
CCTCTCCCGG CCTCTGCAGC CACCGTCCAG CACCGCTTGT CCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Secreted Isoform of Human Lynx1 (SLURP-2): Spatial Structure and Pharmacology of Interactions with Different Types of Acetylcholine Receptors.
Scientific reports630698(2016 Aug)
Lyukmanova EN,Shulepko MA,Shenkarev ZO,Bychkov ML,Paramonov AS,Chugunov AO,Kulbatskii DS,Arvaniti M,Dolejsi E,Schaer T,Arseniev AS,Efremov RG,Thomsen MS,Dolezal V,Bertrand D,Dolgikh DA,Kirpichnikov MP

Organization, evolution and functions of the human and mouse Ly6/uPAR family genes.
Human genomics1010(2016 Apr)
Loughner CL,Bruford EA,McAndrews MS,Delp EE,Swamynathan S,Swamynathan SK

Transcriptional regulation of SLURP2, a psoriasis-associated gene, is under control of IL-22 in the skin: A special reference to the nested gene LYNX1.
International immunopharmacology29(1)71-5(2015 Nov)
Moriwaki Y,Takada K,Tsuji S,Kawashima K,Misawa H

Anti-inflammatory effects of the nicotinergic peptides SLURP-1 and SLURP-2 on human intestinal epithelial cells and immunocytes.
BioMed research international2014609086(2014)
Chernyavsky AI,Galitovskiy V,Shchepotin IB,Grando SA

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SLURP2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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