MMP14 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	MMP14
Entrez Gene ID	4323
Full Name	matrix metallopeptidase 14
Synonyms	MMP-14,MMP-X1,MT-MMP,MT-MMP 1,MT1-MMP,MT1MMP,MTMMP1,WNCHRS
General protein information	Preferred Names matrix metallopeptidase 14 Names matrix metalloproteinase-14 matrix metallopeptidase 14 (membrane-inserted) membrane type 1 metalloprotease membrane-type-1 matrix metalloproteinase
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 14 Map Location: 14q11.2
Summary	Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 protein, and this activity may be involved in tumor invasion. [provided by RefSeq, Jul 2008].
Disorder MIM:	600754
Disorder Html:	?Winchester syndrome, 277950 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_004995.3	NP_004986.1	matrix metalloproteinase-14 preproprotein
NM_004995.4	NP_004986.1	matrix metalloproteinase-14 preproprotein

Pathways from BioSystems

Homologies

Danio rerio (zebrafish)	mmp14b	NP_919395.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP006904	XP_001688107.1
Pan troglodytes (chimpanzee)	MMP14	XP_001157686.1
Bos taurus (cattle)	MMP14	NP_776815.1
Mus musculus (house mouse)	Mmp14	NP_032634.3
Caenorhabditis elegans (roundworm)	H36L18.1	NP_510112.2
Xenopus tropicalis (tropical clawed frog)	mmp14	NP_001025559.1
Homo sapiens (human)	MMP14	NP_004986.1
	MMP14	XP_001100232.1
Rattus norvegicus (Norway rat)	Mmp14	NP_112318.1
Danio rerio (zebrafish)	mmp14a	NP_919397.1
Drosophila melanogaster (fruit fly)	Mmp1	NP_726473.2
Canis lupus familiaris (dog)	MMP14	XP_856947.1

Gene Ontology
Bibliography

Related articles in PubMed

Organelle Specific O-Glycosylation Drives MMP14 Activation, Tumor Growth, and Metastasis.
Nguyen AT, Chia J, Ros M, Hui KM, Saltel F, Bard F
Cancer cell32(5)639-653.e6(2017 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Authors demonstrate that CAIX associates with MMP14 through potential phosphorylation residues within its intracellular domain, and that CAIX enhances MMP14-mediated collagen degradation by directly contributing hydrogen ions required for MMP14 catalytic activity.
Title: The interactome of metabolic enzyme carbonic anhydrase IX reveals novel roles in tumor cell migration and invadopodia/MMP14-mediated invasion.

ERO1alpha plays a crucial role in HSC proliferation via posttranslational modification of collagen and MT1-MMP
Title: Endoplasmic reticulum oxidase 1? is critical for collagen secretion from and membrane type 1-matrix metalloproteinase levels in hepatic stellate cells.

Data suggest that phosphorylation of Thr567 in cytoplasmic tail of MT1-MMP (MMP14) influences behavior of both individual ovarian cancer cells and multicellular aggregates; tumor cells expressing MT1-MMP-T567E phosphomimetic mutant exhibit enhanced cell migration and enhanced cell adhesion to peritoneum and other biological surfaces.
Title: Post-translational modification of the membrane type 1 matrix metalloproteinase (MT1-MMP) cytoplasmic tail impacts ovarian cancer multicellular aggregate dynamics.

MMP14 plays an important mechanistic role in NSCLC progression, by supporting cancer invasiveness, promoting collagen degradation, and releasing HB-EGF, which accelerates lung tumor progression.
Title: Matrix Metalloproteinase 14 promotes lung cancer by cleavage of Heparin-Binding EGF-like Growth Factor.

results suggest that the cytoplasmic domain regulates MT1-MMP function in a manner required for cell survival, but is dispensable for cell migration
Title: The cytoplasmic domain of MT1-MMP is dispensable for migration augmentation but necessary to mediate viability of MCF-7 breast cancer cells.

The following MMP14 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MMP14 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu23037	NM_004995.4 Latest version!	Homo sapiens matrix metallopeptidase 14 (MMP14), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
View Old Accession Versions >>
OHu23037	NM_004995.3	Homo sapiens matrix metallopeptidase 14 (MMP14), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

MMP14 ( NM_004995.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_004986.1 Homo sapiens matrix metallopeptidase 14 (MMP14), mRNA.

Price & Availability↑

CloneID	OHu23037
Clone ID Related Accession (Same CDS sequence)	NM_004995.3 , NM_004995.4
Accession Version	NM_004995.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1749bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-05
Organism	Homo sapiens(human)
Product	matrix metalloproteinase-14 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from HY075830.1, Z48481.1, AL135998.6 and BQ009340.1. This sequence is a reference standard in the RefSeqGene project. On Jul 25, 2013 this sequence version replaced NM_004995.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: HE978355.1, Z48481.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

ATGTCTCCCG CCCCAAGACC CCCCCGTTGT CTCCTGCTCC CCCTGCTCAC GCTCGGCACC 
GCGCTCGCCT CCCTCGGCTC GGCCCAAAGC AGCAGCTTCA GCCCCGAAGC CTGGCTACAG 
CAATATGGCT ACCTGCCTCC CGGGGACCTA CGTACCCACA CACAGCGCTC ACCCCAGTCA 
CTCTCAGCGG CCATCGCTGC CATGCAGAAG TTTTACGGCT TGCAAGTAAC AGGCAAAGCT 
GATGCAGACA CCATGAAGGC CATGAGGCGC CCCCGATGTG GTGTTCCAGA CAAGTTTGGG 
GCTGAGATCA AGGCCAATGT TCGAAGGAAG CGCTACGCCA TCCAGGGTCT CAAATGGCAA 
CATAATGAAA TCACTTTCTG CATCCAGAAT TACACCCCCA AGGTGGGCGA GTATGCCACA 
TACGAGGCCA TTCGCAAGGC GTTCCGCGTG TGGGAGAGTG CCACACCACT GCGCTTCCGC 
GAGGTGCCCT ATGCCTACAT CCGTGAGGGC CATGAGAAGC AGGCCGACAT CATGATCTTC 
TTTGCCGAGG GCTTCCATGG CGACAGCACG CCCTTCGATG GTGAGGGCGG CTTCCTGGCC 
CATGCCTACT TCCCAGGCCC CAACATTGGA GGAGACACCC ACTTTGACTC TGCCGAGCCT 
TGGACTGTCA GGAATGAGGA TCTGAATGGA AATGACATCT TCCTGGTGGC TGTGCACGAG 
CTGGGCCATG CCCTGGGGCT CGAGCATTCC AGTGACCCCT CGGCCATCAT GGCACCCTTT 
TACCAGTGGA TGGACACGGA GAATTTTGTG CTGCCCGATG ATGACCGCCG GGGCATCCAG 
CAACTTTATG GGGGTGAGTC AGGGTTCCCC ACCAAGATGC CCCCTCAACC CAGGACTACC 
TCCCGGCCTT CTGTTCCTGA TAAACCCAAA AACCCCACCT ATGGGCCCAA CATCTGTGAC 
GGGAACTTTG ACACCGTGGC CATGCTCCGA GGGGAGATGT TTGTCTTCAA GGAGCGCTGG 
TTCTGGCGGG TGAGGAATAA CCAAGTGATG GATGGATACC CAATGCCCAT TGGCCAGTTC 
TGGCGGGGCC TGCCTGCGTC CATCAACACT GCCTACGAGA GGAAGGATGG CAAATTCGTC 
TTCTTCAAAG GAGACAAGCA TTGGGTGTTT GATGAGGCGT CCCTGGAACC TGGCTACCCC 
AAGCACATTA AGGAGCTGGG CCGAGGGCTG CCTACCGACA AGATTGATGC TGCTCTCTTC 
TGGATGCCCA ATGGAAAGAC CTACTTCTTC CGTGGAAACA AGTACTACCG TTTCAACGAA 
GAGCTCAGGG CAGTGGATAG CGAGTACCCC AAGAACATCA AAGTCTGGGA AGGGATCCCT 
GAGTCTCCCA GAGGGTCATT CATGGGCAGC GATGAAGTCT TCACTTACTT CTACAAGGGG 
AACAAATACT GGAAATTCAA CAACCAGAAG CTGAAGGTAG AACCGGGCTA CCCCAAGTCA 
GCCCTGAGGG ACTGGATGGG CTGCCCATCG GGAGGCCGGC CGGATGAGGG GACTGAGGAG 
GAGACGGAGG TGATCATCAT TGAGGTGGAC GAGGAGGGCG GCGGGGCGGT GAGCGCGGCT 
GCCGTGGTGC TGCCCGTGCT GCTGCTGCTC CTGGTGCTGG CGGTGGGCCT TGCAGTCTTC 
TTCTTCAGAC GCCATGGGAC CCCCAGGCGA CTGCTCTACT GCCAGCGTTC CCTGCTGGAC 
AAGGTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004986.1
CDS	286..2034
Translation	MSPAPRPPRCLLLPLLTLGTALASLGSAQSSSFSPEAWLQQYGYLPPGDLRTHTQRSPQSLSAAIAAMQKFYGLQVTGKADADTMKAMRRPRCGVPDKFGAEIKANVRRKRYAIQGLKWQHNEITFCIQNYTPKVGEYATYEAIRKAFRVWESATPLRFREVPYAYIREGHEKQADIMIFFAEGFHGDSTPFDGEGGFLAHAYFPGPNIGGDTHFDSAEPWTVRNEDLNGNDIFLVAVHELGHALGLEHSSDPSAIMAPFYQWMDTENFVLPDDDRRGIQQLYGGESGFPTKMPPQPRTTSRPSVPDKPKNPTYGPNICDGNFDTVAMLRGEMFVFKERWFWRVRNNQVMDGYPMPIGQFWRGLPASINTAYERKDGKFVFFKGDKHWVFDEASLEPGYPKHIKELGRGLPTDKIDAALFWMPNGKTYFFRGNKYYRFNEELRAVDSEYPKNIKVWEGIPESPRGSFMGSDEVFTYFYKGNKYWKFNNQKLKVEPGYPKSALRDWMGCPSGGRPDEGTEEETEVIIIEVDEEGGGAVSAAAVVLPVLLLLLVLAVGLAVFFFRRHGTPRRLLYCQRSLLDKV

Target ORF information:

RefSeq Version	NM_004995.3
Organism	Homo sapiens(human)
Definition	Homo sapiens matrix metallopeptidase 14 (MMP14), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004995.3

ORF Insert Sequence:

ATGTCTCCCG CCCCAAGACC CCCCCGTTGT CTCCTGCTCC CCCTGCTCAC GCTCGGCACC 
GCGCTCGCCT CCCTCGGCTC GGCCCAAAGC AGCAGCTTCA GCCCCGAAGC CTGGCTACAG 
CAATATGGCT ACCTGCCTCC CGGGGACCTA CGTACCCACA CACAGCGCTC ACCCCAGTCA 
CTCTCAGCGG CCATCGCTGC CATGCAGAAG TTTTACGGCT TGCAAGTAAC AGGCAAAGCT 
GATGCAGACA CCATGAAGGC CATGAGGCGC CCCCGATGTG GTGTTCCAGA CAAGTTTGGG 
GCTGAGATCA AGGCCAATGT TCGAAGGAAG CGCTACGCCA TCCAGGGTCT CAAATGGCAA 
CATAATGAAA TCACTTTCTG CATCCAGAAT TACACCCCCA AGGTGGGCGA GTATGCCACA 
TACGAGGCCA TTCGCAAGGC GTTCCGCGTG TGGGAGAGTG CCACACCACT GCGCTTCCGC 
GAGGTGCCCT ATGCCTACAT CCGTGAGGGC CATGAGAAGC AGGCCGACAT CATGATCTTC 
TTTGCCGAGG GCTTCCATGG CGACAGCACG CCCTTCGATG GTGAGGGCGG CTTCCTGGCC 
CATGCCTACT TCCCAGGCCC CAACATTGGA GGAGACACCC ACTTTGACTC TGCCGAGCCT 
TGGACTGTCA GGAATGAGGA TCTGAATGGA AATGACATCT TCCTGGTGGC TGTGCACGAG 
CTGGGCCATG CCCTGGGGCT CGAGCATTCC AGTGACCCCT CGGCCATCAT GGCACCCTTT 
TACCAGTGGA TGGACACGGA GAATTTTGTG CTGCCCGATG ATGACCGCCG GGGCATCCAG 
CAACTTTATG GGGGTGAGTC AGGGTTCCCC ACCAAGATGC CCCCTCAACC CAGGACTACC 
TCCCGGCCTT CTGTTCCTGA TAAACCCAAA AACCCCACCT ATGGGCCCAA CATCTGTGAC 
GGGAACTTTG ACACCGTGGC CATGCTCCGA GGGGAGATGT TTGTCTTCAA GGAGCGCTGG 
TTCTGGCGGG TGAGGAATAA CCAAGTGATG GATGGATACC CAATGCCCAT TGGCCAGTTC 
TGGCGGGGCC TGCCTGCGTC CATCAACACT GCCTACGAGA GGAAGGATGG CAAATTCGTC 
TTCTTCAAAG GAGACAAGCA TTGGGTGTTT GATGAGGCGT CCCTGGAACC TGGCTACCCC 
AAGCACATTA AGGAGCTGGG CCGAGGGCTG CCTACCGACA AGATTGATGC TGCTCTCTTC 
TGGATGCCCA ATGGAAAGAC CTACTTCTTC CGTGGAAACA AGTACTACCG TTTCAACGAA 
GAGCTCAGGG CAGTGGATAG CGAGTACCCC AAGAACATCA AAGTCTGGGA AGGGATCCCT 
GAGTCTCCCA GAGGGTCATT CATGGGCAGC GATGAAGTCT TCACTTACTT CTACAAGGGG 
AACAAATACT GGAAATTCAA CAACCAGAAG CTGAAGGTAG AACCGGGCTA CCCCAAGTCA 
GCCCTGAGGG ACTGGATGGG CTGCCCATCG GGAGGCCGGC CGGATGAGGG GACTGAGGAG 
GAGACGGAGG TGATCATCAT TGAGGTGGAC GAGGAGGGCG GCGGGGCGGT GAGCGCGGCT 
GCCGTGGTGC TGCCCGTGCT GCTGCTGCTC CTGGTGCTGG CGGTGGGCCT TGCAGTCTTC 
TTCTTCAGAC GCCATGGGAC CCCCAGGCGA CTGCTCTACT GCCAGCGTTC CCTGCTGGAC 
AAGGTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MMP14 ( NM_004995.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_004986.1 Homo sapiens matrix metallopeptidase 14 (MMP14), mRNA.

Price & Availability↑

CloneID	OHu23037
Clone ID Related Accession (Same CDS sequence)	NM_004995.3 , NM_004995.4
Accession Version	NM_004995.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1749bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-09
Organism	Homo sapiens(human)
Product	matrix metalloproteinase-14 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from HY075830.1, Z48481.1, AL135998.6 and BQ009340.1. This sequence is a reference standard in the RefSeqGene project. On Nov 23, 2018 this sequence version replaced NM_004995.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK312657.1, HE978355.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000311852.11/ ENSP00000308208.6 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGTCTCCCG CCCCAAGACC CCCCCGTTGT CTCCTGCTCC CCCTGCTCAC GCTCGGCACC 
GCGCTCGCCT CCCTCGGCTC GGCCCAAAGC AGCAGCTTCA GCCCCGAAGC CTGGCTACAG 
CAATATGGCT ACCTGCCTCC CGGGGACCTA CGTACCCACA CACAGCGCTC ACCCCAGTCA 
CTCTCAGCGG CCATCGCTGC CATGCAGAAG TTTTACGGCT TGCAAGTAAC AGGCAAAGCT 
GATGCAGACA CCATGAAGGC CATGAGGCGC CCCCGATGTG GTGTTCCAGA CAAGTTTGGG 
GCTGAGATCA AGGCCAATGT TCGAAGGAAG CGCTACGCCA TCCAGGGTCT CAAATGGCAA 
CATAATGAAA TCACTTTCTG CATCCAGAAT TACACCCCCA AGGTGGGCGA GTATGCCACA 
TACGAGGCCA TTCGCAAGGC GTTCCGCGTG TGGGAGAGTG CCACACCACT GCGCTTCCGC 
GAGGTGCCCT ATGCCTACAT CCGTGAGGGC CATGAGAAGC AGGCCGACAT CATGATCTTC 
TTTGCCGAGG GCTTCCATGG CGACAGCACG CCCTTCGATG GTGAGGGCGG CTTCCTGGCC 
CATGCCTACT TCCCAGGCCC CAACATTGGA GGAGACACCC ACTTTGACTC TGCCGAGCCT 
TGGACTGTCA GGAATGAGGA TCTGAATGGA AATGACATCT TCCTGGTGGC TGTGCACGAG 
CTGGGCCATG CCCTGGGGCT CGAGCATTCC AGTGACCCCT CGGCCATCAT GGCACCCTTT 
TACCAGTGGA TGGACACGGA GAATTTTGTG CTGCCCGATG ATGACCGCCG GGGCATCCAG 
CAACTTTATG GGGGTGAGTC AGGGTTCCCC ACCAAGATGC CCCCTCAACC CAGGACTACC 
TCCCGGCCTT CTGTTCCTGA TAAACCCAAA AACCCCACCT ATGGGCCCAA CATCTGTGAC 
GGGAACTTTG ACACCGTGGC CATGCTCCGA GGGGAGATGT TTGTCTTCAA GGAGCGCTGG 
TTCTGGCGGG TGAGGAATAA CCAAGTGATG GATGGATACC CAATGCCCAT TGGCCAGTTC 
TGGCGGGGCC TGCCTGCGTC CATCAACACT GCCTACGAGA GGAAGGATGG CAAATTCGTC 
TTCTTCAAAG GAGACAAGCA TTGGGTGTTT GATGAGGCGT CCCTGGAACC TGGCTACCCC 
AAGCACATTA AGGAGCTGGG CCGAGGGCTG CCTACCGACA AGATTGATGC TGCTCTCTTC 
TGGATGCCCA ATGGAAAGAC CTACTTCTTC CGTGGAAACA AGTACTACCG TTTCAACGAA 
GAGCTCAGGG CAGTGGATAG CGAGTACCCC AAGAACATCA AAGTCTGGGA AGGGATCCCT 
GAGTCTCCCA GAGGGTCATT CATGGGCAGC GATGAAGTCT TCACTTACTT CTACAAGGGG 
AACAAATACT GGAAATTCAA CAACCAGAAG CTGAAGGTAG AACCGGGCTA CCCCAAGTCA 
GCCCTGAGGG ACTGGATGGG CTGCCCATCG GGAGGCCGGC CGGATGAGGG GACTGAGGAG 
GAGACGGAGG TGATCATCAT TGAGGTGGAC GAGGAGGGCG GCGGGGCGGT GAGCGCGGCT 
GCCGTGGTGC TGCCCGTGCT GCTGCTGCTC CTGGTGCTGG CGGTGGGCCT TGCAGTCTTC 
TTCTTCAGAC GCCATGGGAC CCCCAGGCGA CTGCTCTACT GCCAGCGTTC CCTGCTGGAC 
AAGGTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004986.1
CDS	234..1982
Translation	MSPAPRPPRCLLLPLLTLGTALASLGSAQSSSFSPEAWLQQYGYLPPGDLRTHTQRSPQSLSAAIAAMQKFYGLQVTGKADADTMKAMRRPRCGVPDKFGAEIKANVRRKRYAIQGLKWQHNEITFCIQNYTPKVGEYATYEAIRKAFRVWESATPLRFREVPYAYIREGHEKQADIMIFFAEGFHGDSTPFDGEGGFLAHAYFPGPNIGGDTHFDSAEPWTVRNEDLNGNDIFLVAVHELGHALGLEHSSDPSAIMAPFYQWMDTENFVLPDDDRRGIQQLYGGESGFPTKMPPQPRTTSRPSVPDKPKNPTYGPNICDGNFDTVAMLRGEMFVFKERWFWRVRNNQVMDGYPMPIGQFWRGLPASINTAYERKDGKFVFFKGDKHWVFDEASLEPGYPKHIKELGRGLPTDKIDAALFWMPNGKTYFFRGNKYYRFNEELRAVDSEYPKNIKVWEGIPESPRGSFMGSDEVFTYFYKGNKYWKFNNQKLKVEPGYPKSALRDWMGCPSGGRPDEGTEEETEVIIIEVDEEGGGAVSAAAVVLPVLLLLLVLAVGLAVFFFRRHGTPRRLLYCQRSLLDKV

Target ORF information:

RefSeq Version	NM_004995.4
Organism	Homo sapiens(human)
Definition	Homo sapiens matrix metallopeptidase 14 (MMP14), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004995.4

ORF Insert Sequence:

ATGTCTCCCG CCCCAAGACC CCCCCGTTGT CTCCTGCTCC CCCTGCTCAC GCTCGGCACC 
GCGCTCGCCT CCCTCGGCTC GGCCCAAAGC AGCAGCTTCA GCCCCGAAGC CTGGCTACAG 
CAATATGGCT ACCTGCCTCC CGGGGACCTA CGTACCCACA CACAGCGCTC ACCCCAGTCA 
CTCTCAGCGG CCATCGCTGC CATGCAGAAG TTTTACGGCT TGCAAGTAAC AGGCAAAGCT 
GATGCAGACA CCATGAAGGC CATGAGGCGC CCCCGATGTG GTGTTCCAGA CAAGTTTGGG 
GCTGAGATCA AGGCCAATGT TCGAAGGAAG CGCTACGCCA TCCAGGGTCT CAAATGGCAA 
CATAATGAAA TCACTTTCTG CATCCAGAAT TACACCCCCA AGGTGGGCGA GTATGCCACA 
TACGAGGCCA TTCGCAAGGC GTTCCGCGTG TGGGAGAGTG CCACACCACT GCGCTTCCGC 
GAGGTGCCCT ATGCCTACAT CCGTGAGGGC CATGAGAAGC AGGCCGACAT CATGATCTTC 
TTTGCCGAGG GCTTCCATGG CGACAGCACG CCCTTCGATG GTGAGGGCGG CTTCCTGGCC 
CATGCCTACT TCCCAGGCCC CAACATTGGA GGAGACACCC ACTTTGACTC TGCCGAGCCT 
TGGACTGTCA GGAATGAGGA TCTGAATGGA AATGACATCT TCCTGGTGGC TGTGCACGAG 
CTGGGCCATG CCCTGGGGCT CGAGCATTCC AGTGACCCCT CGGCCATCAT GGCACCCTTT 
TACCAGTGGA TGGACACGGA GAATTTTGTG CTGCCCGATG ATGACCGCCG GGGCATCCAG 
CAACTTTATG GGGGTGAGTC AGGGTTCCCC ACCAAGATGC CCCCTCAACC CAGGACTACC 
TCCCGGCCTT CTGTTCCTGA TAAACCCAAA AACCCCACCT ATGGGCCCAA CATCTGTGAC 
GGGAACTTTG ACACCGTGGC CATGCTCCGA GGGGAGATGT TTGTCTTCAA GGAGCGCTGG 
TTCTGGCGGG TGAGGAATAA CCAAGTGATG GATGGATACC CAATGCCCAT TGGCCAGTTC 
TGGCGGGGCC TGCCTGCGTC CATCAACACT GCCTACGAGA GGAAGGATGG CAAATTCGTC 
TTCTTCAAAG GAGACAAGCA TTGGGTGTTT GATGAGGCGT CCCTGGAACC TGGCTACCCC 
AAGCACATTA AGGAGCTGGG CCGAGGGCTG CCTACCGACA AGATTGATGC TGCTCTCTTC 
TGGATGCCCA ATGGAAAGAC CTACTTCTTC CGTGGAAACA AGTACTACCG TTTCAACGAA 
GAGCTCAGGG CAGTGGATAG CGAGTACCCC AAGAACATCA AAGTCTGGGA AGGGATCCCT 
GAGTCTCCCA GAGGGTCATT CATGGGCAGC GATGAAGTCT TCACTTACTT CTACAAGGGG 
AACAAATACT GGAAATTCAA CAACCAGAAG CTGAAGGTAG AACCGGGCTA CCCCAAGTCA 
GCCCTGAGGG ACTGGATGGG CTGCCCATCG GGAGGCCGGC CGGATGAGGG GACTGAGGAG 
GAGACGGAGG TGATCATCAT TGAGGTGGAC GAGGAGGGCG GCGGGGCGGT GAGCGCGGCT 
GCCGTGGTGC TGCCCGTGCT GCTGCTGCTC CTGGTGCTGG CGGTGGGCCT TGCAGTCTTC 
TTCTTCAGAC GCCATGGGAC CCCCAGGCGA CTGCTCTACT GCCAGCGTTC CCTGCTGGAC 
AAGGTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Organelle Specific O-Glycosylation Drives MMP14 Activation, Tumor Growth, and Metastasis.
Cancer cell32(5)639-653.e6(2017 Nov)
Nguyen AT,Chia J,Ros M,Hui KM,Saltel F,Bard F

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MMP14 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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