ASGR1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	ASGR1
Entrez Gene ID	432
Full Name	asialoglycoprotein receptor 1
Synonyms	ASGPR,ASGPR1,CLEC4H1,HL-1
General protein information	Preferred Names asialoglycoprotein receptor 1 Names asialoglycoprotein receptor 1 C-type lectin domain family 4 member H1 hepatic lectin H1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 17 Map Location: 17p13.1
Summary	This gene encodes a subunit of the asialoglycoprotein receptor. This receptor is a transmembrane protein that plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues. The asialoglycoprotein receptor may facilitate hepatic infection by multiple viruses including hepatitis B, and is also a target for liver-specific drug delivery. The asialoglycoprotein receptor is a hetero-oligomeric protein composed of major and minor subunits, which are encoded by different genes. The protein encoded by this gene is the more abundant major subunit. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011].
Disorder MIM:	108360

mRNA and Protein(s)

mRNA	Protein	Name
XM_011523861.1	XP_011522163.1	asialoglycoprotein receptor 1 isoform X1
NM_001197216.2	NP_001184145.1	asialoglycoprotein receptor 1 isoform b
NM_001671.5	NP_001662.1	asialoglycoprotein receptor 1 isoform a
NM_001671.4	NP_001662.1	asialoglycoprotein receptor 1 isoform a
XM_011523861.2	XP_011522163.1	asialoglycoprotein receptor 1 isoform X1

Pathways from BioSystems

Homologies

Homo sapiens (human)	ASGR1	NP_001662.1
Bos taurus (cattle)	ASGR1	NP_001032679.1
Canis lupus familiaris (dog)	ASGR1	XP_546579.2
Mus musculus (house mouse)	Asgr1	NP_033844.1
Rattus norvegicus (Norway rat)	Asgr1	NP_036635.1
Pan troglodytes (chimpanzee)	ASGR1	XP_001174756.2

Gene Ontology
Bibliography

Related articles in PubMed

Generation of an ASGR1 homozygous mutant human embryonic stem cell line WAe001-A-6 using CRISPR/Cas9.
Xu Y, Wu Y, Guo D, Gao G, Lai K, Yang F, Wang K, Wu H, Lai L, Li J, Xu K, Li YX
Stem cell research2229-32(2017 Jul)

PEGylation potentiates hepatoma cell targeted liposome-mediated in vitro gene delivery via the asialoglycoprotein receptor.
Mkhwanazi NK, de Koning CB, van Otterlo WAL, Ariatti M, Singh M
Zeitschrift fur Naturforschung. C, Journal of biosciences72(7-8)293-301(2017 Jul)

The asialoglycoprotein receptor suppresses the metastasis of hepatocellular carcinoma via LASS2-mediated inhibition of V-ATPase activity.
Gu D, Jin H, Jin G, Wang C, Wang N, Hu F, Luo Q, Chu W, Yao M, Qin W
Cancer letters379(1)107-16(2016 08)

Platelet clearance by the hepatic Ashwell-Morrell receptor: mechanisms and biological significance.
Hoffmeister KM, Falet H
Thrombosis research141 Suppl 2S68-72(2016 May)

Establishment of a functional cell line expressing both subunits of H1a and H2c of human hepatocyte surface molecule ASGPR.
Hu B, Yang Y, Liu J, Ma Z, Huang H, Liu S, Yu Y, Hao Y, Wang B, Lu M, Yang D
Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban30(5)556-61(2010 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

PEGylated lipoplexes were well tolerated by both HEK293 (ASGP-R-negative) and HepG2 (ASGP-R-positive) cell lines and delivered DNA to the hepatoma cell line HepG2 by ASGP-R mediation at levels three-fold greater than nonPEGylated lipoplexes.
Title: PEGylation potentiates hepatoma cell targeted liposome-mediated in vitro gene delivery via the asialoglycoprotein receptor.

findings show that the hepatitis E virus (HEV) ORF2 protein interacts directly with the ectodomain of both ASGR1 and ASGR2; ASGPR is involved in and facilitates HEV infection by binding to ORF2
Title: Asialoglycoprotein receptor facilitates infection of PLC/PRF/5 cells by HEV through interaction with ORF2.

ASGR1 can inhibit the activity of V-ATPase by interacting with LASS2, thereby suppressing the metastatic potential of hepatoma cells.
Title: The asialoglycoprotein receptor suppresses the metastasis of hepatocellular carcinoma via LASS2-mediated inhibition of V-ATPase activity.

ASGR1 haploinsufficiency was associated with reduced levels of non-HDL cholesterol and a reduced risk of coronary artery disease.
Title: Variant ASGR1 Associated with a Reduced Risk of Coronary Artery Disease.

This review will focus on the mechanisms of platelet senescence with specific emphasis on the role of post-translational modifications in platelet life-span and thrombopoietin production downstream of the hepatic Ashwell-Morrell receptor, originally termed asialoglycoprotein receptor (ASGPR).
Title: Platelet clearance by the hepatic Ashwell-Morrell receptor: mechanisms and biological significance.

The following ASGR1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ASGR1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu03658	NM_001671.5 Latest version!	Homo sapiens asialoglycoprotein receptor 1 (ASGR1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
OHu03658	XM_011523861.2 Latest version!	Homo sapiens asialoglycoprotein receptor 1 (ASGR1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
OHu05679	NM_001197216.2 Latest version!	Homo sapiens asialoglycoprotein receptor 1 (ASGR1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
View Old Accession Versions >>
OHu03658	NM_001671.4	Homo sapiens asialoglycoprotein receptor 1 (ASGR1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
OHu03658	XM_011523861.1	Homo sapiens asialoglycoprotein receptor 1 (ASGR1), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
Hide Old Accession Versions >>

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

ASGR1 ( NM_001671.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_001662.1 Homo sapiens asialoglycoprotein receptor 1 (ASGR1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu03658
Clone ID Related Accession (Same CDS sequence)	XM_011523861.1 , NM_001671.5 , NM_001671.4 , XM_011523861.2
Accession Version	NM_001671.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 876bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-01
Organism	Homo sapiens(human)
Product	asialoglycoprotein receptor 1 isoform a
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BQ653541.1 and BC032130.2. On Nov 24, 2018 this sequence version replaced NM_001671.4. Transcript Variant: This variant (1), also known as H1a, represents the longer transcript and encodes the longer isoform (a). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR5189664.50537.1, SRR5189664.118868.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000269299.8/ ENSP00000269299.3 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGACCAAGG AGTATCAAGA CCTTCAGCAT CTGGACAATG AGGAGAGTGA CCACCATCAG 
CTCAGAAAAG GGCCACCTCC TCCCCAGCCC CTCCTGCAGC GTCTCTGCTC CGGACCTCGC 
CTCCTCCTGC TCTCCCTGGG CCTCAGCCTC CTGCTGCTTG TGGTTGTCTG TGTGATCGGA 
TCCCAAAACT CCCAGCTGCA GGAGGAGCTG CGGGGCCTGA GAGAGACGTT CAGCAACTTC 
ACAGCGAGCA CGGAGGCCCA GGTCAAGGGC TTGAGCACCC AGGGAGGCAA TGTGGGAAGA 
AAGATGAAGT CGCTAGAGTC CCAGCTGGAG AAACAGCAGA AGGACCTGAG TGAAGATCAC 
TCCAGCCTGC TGCTCCACGT GAAGCAGTTC GTGTCTGACC TGCGGAGCCT GAGCTGTCAG 
ATGGCGGCGC TCCAGGGCAA TGGCTCAGAA AGGACCTGCT GCCCGGTCAA CTGGGTGGAG 
CACGAGCGCA GCTGCTACTG GTTCTCTCGC TCCGGGAAGG CCTGGGCTGA CGCCGACAAC 
TACTGCCGGC TGGAGGACGC GCACCTGGTG GTGGTCACGT CCTGGGAGGA GCAGAAATTT 
GTCCAGCACC ACATAGGCCC TGTGAACACC TGGATGGGCC TCCACGACCA AAACGGGCCC 
TGGAAGTGGG TGGACGGGAC GGACTACGAG ACGGGCTTCA AGAACTGGAG GCCGGAGCAG 
CCGGACGACT GGTACGGCCA CGGGCTCGGA GGAGGCGAGG ACTGTGCCCA CTTCACCGAC 
GACGGCCGCT GGAACGACGA CGTCTGCCAG AGGCCCTACC GCTGGGTCTG CGAGACAGAG 
CTGGACAAGG CCAGCCAGGA GCCACCTCTC CTTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001662.1
CDS	207..1082
Translation	MTKEYQDLQHLDNEESDHHQLRKGPPPPQPLLQRLCSGPRLLLLSLGLSLLLLVVVCVIGSQNSQLQEELRGLRETFSNFTASTEAQVKGLSTQGGNVGRKMKSLESQLEKQQKDLSEDHSSLLLHVKQFVSDLRSLSCQMAALQGNGSERTCCPVNWVEHERSCYWFSRSGKAWADADNYCRLEDAHLVVVTSWEEQKFVQHHIGPVNTWMGLHDQNGPWKWVDGTDYETGFKNWRPEQPDDWYGHGLGGGEDCAHFTDDGRWNDDVCQRPYRWVCETELDKASQEPPLL

Target ORF information:

RefSeq Version	NM_001671.5
Organism	Homo sapiens(human)
Definition	Homo sapiens asialoglycoprotein receptor 1 (ASGR1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001671.5

ORF Insert Sequence:

ATGACCAAGG AGTATCAAGA CCTTCAGCAT CTGGACAATG AGGAGAGTGA CCACCATCAG 
CTCAGAAAAG GGCCACCTCC TCCCCAGCCC CTCCTGCAGC GTCTCTGCTC CGGACCTCGC 
CTCCTCCTGC TCTCCCTGGG CCTCAGCCTC CTGCTGCTTG TGGTTGTCTG TGTGATCGGA 
TCCCAAAACT CCCAGCTGCA GGAGGAGCTG CGGGGCCTGA GAGAGACGTT CAGCAACTTC 
ACAGCGAGCA CGGAGGCCCA GGTCAAGGGC TTGAGCACCC AGGGAGGCAA TGTGGGAAGA 
AAGATGAAGT CGCTAGAGTC CCAGCTGGAG AAACAGCAGA AGGACCTGAG TGAAGATCAC 
TCCAGCCTGC TGCTCCACGT GAAGCAGTTC GTGTCTGACC TGCGGAGCCT GAGCTGTCAG 
ATGGCGGCGC TCCAGGGCAA TGGCTCAGAA AGGACCTGCT GCCCGGTCAA CTGGGTGGAG 
CACGAGCGCA GCTGCTACTG GTTCTCTCGC TCCGGGAAGG CCTGGGCTGA CGCCGACAAC 
TACTGCCGGC TGGAGGACGC GCACCTGGTG GTGGTCACGT CCTGGGAGGA GCAGAAATTT 
GTCCAGCACC ACATAGGCCC TGTGAACACC TGGATGGGCC TCCACGACCA AAACGGGCCC 
TGGAAGTGGG TGGACGGGAC GGACTACGAG ACGGGCTTCA AGAACTGGAG GCCGGAGCAG 
CCGGACGACT GGTACGGCCA CGGGCTCGGA GGAGGCGAGG ACTGTGCCCA CTTCACCGAC 
GACGGCCGCT GGAACGACGA CGTCTGCCAG AGGCCCTACC GCTGGGTCTG CGAGACAGAG 
CTGGACAAGG CCAGCCAGGA GCCACCTCTC CTTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ASGR1 ( NM_001671.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_001662.1 Homo sapiens asialoglycoprotein receptor 1 (ASGR1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu03658
Clone ID Related Accession (Same CDS sequence)	XM_011523861.1 , NM_001671.5 , NM_001671.4 , XM_011523861.2
Accession Version	NM_001671.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 876bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-02
Organism	Homo sapiens(human)
Product	asialoglycoprotein receptor 1 isoform a
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BQ653541.1 and BC032130.2. On Jan 19, 2011 this sequence version replaced NM_001671.3. Transcript Variant: This variant (1), also known as H1a, represents the longer transcript and encodes the longer isoform (a). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB070933.1, AK308375.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGACCAAGG AGTATCAAGA CCTTCAGCAT CTGGACAATG AGGAGAGTGA CCACCATCAG 
CTCAGAAAAG GGCCACCTCC TCCCCAGCCC CTCCTGCAGC GTCTCTGCTC CGGACCTCGC 
CTCCTCCTGC TCTCCCTGGG CCTCAGCCTC CTGCTGCTTG TGGTTGTCTG TGTGATCGGA 
TCCCAAAACT CCCAGCTGCA GGAGGAGCTG CGGGGCCTGA GAGAGACGTT CAGCAACTTC 
ACAGCGAGCA CGGAGGCCCA GGTCAAGGGC TTGAGCACCC AGGGAGGCAA TGTGGGAAGA 
AAGATGAAGT CGCTAGAGTC CCAGCTGGAG AAACAGCAGA AGGACCTGAG TGAAGATCAC 
TCCAGCCTGC TGCTCCACGT GAAGCAGTTC GTGTCTGACC TGCGGAGCCT GAGCTGTCAG 
ATGGCGGCGC TCCAGGGCAA TGGCTCAGAA AGGACCTGCT GCCCGGTCAA CTGGGTGGAG 
CACGAGCGCA GCTGCTACTG GTTCTCTCGC TCCGGGAAGG CCTGGGCTGA CGCCGACAAC 
TACTGCCGGC TGGAGGACGC GCACCTGGTG GTGGTCACGT CCTGGGAGGA GCAGAAATTT 
GTCCAGCACC ACATAGGCCC TGTGAACACC TGGATGGGCC TCCACGACCA AAACGGGCCC 
TGGAAGTGGG TGGACGGGAC GGACTACGAG ACGGGCTTCA AGAACTGGAG GCCGGAGCAG 
CCGGACGACT GGTACGGCCA CGGGCTCGGA GGAGGCGAGG ACTGTGCCCA CTTCACCGAC 
GACGGCCGCT GGAACGACGA CGTCTGCCAG AGGCCCTACC GCTGGGTCTG CGAGACAGAG 
CTGGACAAGG CCAGCCAGGA GCCACCTCTC CTTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001662.1
CDS	401..1276
Translation	MTKEYQDLQHLDNEESDHHQLRKGPPPPQPLLQRLCSGPRLLLLSLGLSLLLLVVVCVIGSQNSQLQEELRGLRETFSNFTASTEAQVKGLSTQGGNVGRKMKSLESQLEKQQKDLSEDHSSLLLHVKQFVSDLRSLSCQMAALQGNGSERTCCPVNWVEHERSCYWFSRSGKAWADADNYCRLEDAHLVVVTSWEEQKFVQHHIGPVNTWMGLHDQNGPWKWVDGTDYETGFKNWRPEQPDDWYGHGLGGGEDCAHFTDDGRWNDDVCQRPYRWVCETELDKASQEPPLL

Target ORF information:

RefSeq Version	NM_001671.4
Organism	Homo sapiens(human)
Definition	Homo sapiens asialoglycoprotein receptor 1 (ASGR1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001671.4

ORF Insert Sequence:

ATGACCAAGG AGTATCAAGA CCTTCAGCAT CTGGACAATG AGGAGAGTGA CCACCATCAG 
CTCAGAAAAG GGCCACCTCC TCCCCAGCCC CTCCTGCAGC GTCTCTGCTC CGGACCTCGC 
CTCCTCCTGC TCTCCCTGGG CCTCAGCCTC CTGCTGCTTG TGGTTGTCTG TGTGATCGGA 
TCCCAAAACT CCCAGCTGCA GGAGGAGCTG CGGGGCCTGA GAGAGACGTT CAGCAACTTC 
ACAGCGAGCA CGGAGGCCCA GGTCAAGGGC TTGAGCACCC AGGGAGGCAA TGTGGGAAGA 
AAGATGAAGT CGCTAGAGTC CCAGCTGGAG AAACAGCAGA AGGACCTGAG TGAAGATCAC 
TCCAGCCTGC TGCTCCACGT GAAGCAGTTC GTGTCTGACC TGCGGAGCCT GAGCTGTCAG 
ATGGCGGCGC TCCAGGGCAA TGGCTCAGAA AGGACCTGCT GCCCGGTCAA CTGGGTGGAG 
CACGAGCGCA GCTGCTACTG GTTCTCTCGC TCCGGGAAGG CCTGGGCTGA CGCCGACAAC 
TACTGCCGGC TGGAGGACGC GCACCTGGTG GTGGTCACGT CCTGGGAGGA GCAGAAATTT 
GTCCAGCACC ACATAGGCCC TGTGAACACC TGGATGGGCC TCCACGACCA AAACGGGCCC 
TGGAAGTGGG TGGACGGGAC GGACTACGAG ACGGGCTTCA AGAACTGGAG GCCGGAGCAG 
CCGGACGACT GGTACGGCCA CGGGCTCGGA GGAGGCGAGG ACTGTGCCCA CTTCACCGAC 
GACGGCCGCT GGAACGACGA CGTCTGCCAG AGGCCCTACC GCTGGGTCTG CGAGACAGAG 
CTGGACAAGG CCAGCCAGGA GCCACCTCTC CTTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ASGR1 ( XM_011523861.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_011522163.1 Homo sapiens asialoglycoprotein receptor 1 (ASGR1), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu03658
Clone ID Related Accession (Same CDS sequence)	XM_011523861.1 , NM_001671.5 , NM_001671.4 , XM_011523861.2
Accession Version	XM_011523861.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 876bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-03-11
Organism	Homo sapiens(Human)
Product	asialoglycoprotein receptor 1 isoform X1
Comment

ATGACCAAGG AGTATCAAGA CCTTCAGCAT CTGGACAATG AGGAGAGTGA CCACCATCAG 
CTCAGAAAAG GGCCACCTCC TCCCCAGCCC CTCCTGCAGC GTCTCTGCTC CGGACCTCGC 
CTCCTCCTGC TCTCCCTGGG CCTCAGCCTC CTGCTGCTTG TGGTTGTCTG TGTGATCGGA 
TCCCAAAACT CCCAGCTGCA GGAGGAGCTG CGGGGCCTGA GAGAGACGTT CAGCAACTTC 
ACAGCGAGCA CGGAGGCCCA GGTCAAGGGC TTGAGCACCC AGGGAGGCAA TGTGGGAAGA 
AAGATGAAGT CGCTAGAGTC CCAGCTGGAG AAACAGCAGA AGGACCTGAG TGAAGATCAC 
TCCAGCCTGC TGCTCCACGT GAAGCAGTTC GTGTCTGACC TGCGGAGCCT GAGCTGTCAG 
ATGGCGGCGC TCCAGGGCAA TGGCTCAGAA AGGACCTGCT GCCCGGTCAA CTGGGTGGAG 
CACGAGCGCA GCTGCTACTG GTTCTCTCGC TCCGGGAAGG CCTGGGCTGA CGCCGACAAC 
TACTGCCGGC TGGAGGACGC GCACCTGGTG GTGGTCACGT CCTGGGAGGA GCAGAAATTT 
GTCCAGCACC ACATAGGCCC TGTGAACACC TGGATGGGCC TCCACGACCA AAACGGGCCC 
TGGAAGTGGG TGGACGGGAC GGACTACGAG ACGGGCTTCA AGAACTGGAG GCCGGAGCAG 
CCGGACGACT GGTACGGCCA CGGGCTCGGA GGAGGCGAGG ACTGTGCCCA CTTCACCGAC 
GACGGCCGCT GGAACGACGA CGTCTGCCAG AGGCCCTACC GCTGGGTCTG CGAGACAGAG 
CTGGACAAGG CCAGCCAGGA GCCACCTCTC CTTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011522163.1
Translation	MTKEYQDLQHLDNEESDHHQLRKGPPPPQPLLQRLCSGPRLLLLSLGLSLLLLVVVCVIGSQNSQLQEELRGLRETFSNFTASTEAQVKGLSTQGGNVGRKMKSLESQLEKQQKDLSEDHSSLLLHVKQFVSDLRSLSCQMAALQGNGSERTCCPVNWVEHERSCYWFSRSGKAWADADNYCRLEDAHLVVVTSWEEQKFVQHHIGPVNTWMGLHDQNGPWKWVDGTDYETGFKNWRPEQPDDWYGHGLGGGEDCAHFTDDGRWNDDVCQRPYRWVCETELDKASQEPPLL

Target ORF information:

RefSeq Version	XM_011523861.1
Organism	Homo sapiens(Human)
Definition	Homo sapiens asialoglycoprotein receptor 1 (ASGR1), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011523861.1

ORF Insert Sequence:

ATGACCAAGG AGTATCAAGA CCTTCAGCAT CTGGACAATG AGGAGAGTGA CCACCATCAG 
CTCAGAAAAG GGCCACCTCC TCCCCAGCCC CTCCTGCAGC GTCTCTGCTC CGGACCTCGC 
CTCCTCCTGC TCTCCCTGGG CCTCAGCCTC CTGCTGCTTG TGGTTGTCTG TGTGATCGGA 
TCCCAAAACT CCCAGCTGCA GGAGGAGCTG CGGGGCCTGA GAGAGACGTT CAGCAACTTC 
ACAGCGAGCA CGGAGGCCCA GGTCAAGGGC TTGAGCACCC AGGGAGGCAA TGTGGGAAGA 
AAGATGAAGT CGCTAGAGTC CCAGCTGGAG AAACAGCAGA AGGACCTGAG TGAAGATCAC 
TCCAGCCTGC TGCTCCACGT GAAGCAGTTC GTGTCTGACC TGCGGAGCCT GAGCTGTCAG 
ATGGCGGCGC TCCAGGGCAA TGGCTCAGAA AGGACCTGCT GCCCGGTCAA CTGGGTGGAG 
CACGAGCGCA GCTGCTACTG GTTCTCTCGC TCCGGGAAGG CCTGGGCTGA CGCCGACAAC 
TACTGCCGGC TGGAGGACGC GCACCTGGTG GTGGTCACGT CCTGGGAGGA GCAGAAATTT 
GTCCAGCACC ACATAGGCCC TGTGAACACC TGGATGGGCC TCCACGACCA AAACGGGCCC 
TGGAAGTGGG TGGACGGGAC GGACTACGAG ACGGGCTTCA AGAACTGGAG GCCGGAGCAG 
CCGGACGACT GGTACGGCCA CGGGCTCGGA GGAGGCGAGG ACTGTGCCCA CTTCACCGAC 
GACGGCCGCT GGAACGACGA CGTCTGCCAG AGGCCCTACC GCTGGGTCTG CGAGACAGAG 
CTGGACAAGG CCAGCCAGGA GCCACCTCTC CTTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ASGR1 ( XM_011523861.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011522163.1 Homo sapiens asialoglycoprotein receptor 1 (ASGR1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu03658
Clone ID Related Accession (Same CDS sequence)	XM_011523861.1 , NM_001671.5 , NM_001671.4 , XM_011523861.2
Accession Version	XM_011523861.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 876bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	asialoglycoprotein receptor 1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000017.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011523861.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGACCAAGG AGTATCAAGA CCTTCAGCAT CTGGACAATG AGGAGAGTGA CCACCATCAG 
CTCAGAAAAG GGCCACCTCC TCCCCAGCCC CTCCTGCAGC GTCTCTGCTC CGGACCTCGC 
CTCCTCCTGC TCTCCCTGGG CCTCAGCCTC CTGCTGCTTG TGGTTGTCTG TGTGATCGGA 
TCCCAAAACT CCCAGCTGCA GGAGGAGCTG CGGGGCCTGA GAGAGACGTT CAGCAACTTC 
ACAGCGAGCA CGGAGGCCCA GGTCAAGGGC TTGAGCACCC AGGGAGGCAA TGTGGGAAGA 
AAGATGAAGT CGCTAGAGTC CCAGCTGGAG AAACAGCAGA AGGACCTGAG TGAAGATCAC 
TCCAGCCTGC TGCTCCACGT GAAGCAGTTC GTGTCTGACC TGCGGAGCCT GAGCTGTCAG 
ATGGCGGCGC TCCAGGGCAA TGGCTCAGAA AGGACCTGCT GCCCGGTCAA CTGGGTGGAG 
CACGAGCGCA GCTGCTACTG GTTCTCTCGC TCCGGGAAGG CCTGGGCTGA CGCCGACAAC 
TACTGCCGGC TGGAGGACGC GCACCTGGTG GTGGTCACGT CCTGGGAGGA GCAGAAATTT 
GTCCAGCACC ACATAGGCCC TGTGAACACC TGGATGGGCC TCCACGACCA AAACGGGCCC 
TGGAAGTGGG TGGACGGGAC GGACTACGAG ACGGGCTTCA AGAACTGGAG GCCGGAGCAG 
CCGGACGACT GGTACGGCCA CGGGCTCGGA GGAGGCGAGG ACTGTGCCCA CTTCACCGAC 
GACGGCCGCT GGAACGACGA CGTCTGCCAG AGGCCCTACC GCTGGGTCTG CGAGACAGAG 
CTGGACAAGG CCAGCCAGGA GCCACCTCTC CTTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011522163.1
CDS	308..1183
Translation	MTKEYQDLQHLDNEESDHHQLRKGPPPPQPLLQRLCSGPRLLLLSLGLSLLLLVVVCVIGSQNSQLQEELRGLRETFSNFTASTEAQVKGLSTQGGNVGRKMKSLESQLEKQQKDLSEDHSSLLLHVKQFVSDLRSLSCQMAALQGNGSERTCCPVNWVEHERSCYWFSRSGKAWADADNYCRLEDAHLVVVTSWEEQKFVQHHIGPVNTWMGLHDQNGPWKWVDGTDYETGFKNWRPEQPDDWYGHGLGGGEDCAHFTDDGRWNDDVCQRPYRWVCETELDKASQEPPLL

Target ORF information:

RefSeq Version	XM_011523861.2
Organism	Homo sapiens(human)
Definition	Homo sapiens asialoglycoprotein receptor 1 (ASGR1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011523861.2

ORF Insert Sequence:

ATGACCAAGG AGTATCAAGA CCTTCAGCAT CTGGACAATG AGGAGAGTGA CCACCATCAG 
CTCAGAAAAG GGCCACCTCC TCCCCAGCCC CTCCTGCAGC GTCTCTGCTC CGGACCTCGC 
CTCCTCCTGC TCTCCCTGGG CCTCAGCCTC CTGCTGCTTG TGGTTGTCTG TGTGATCGGA 
TCCCAAAACT CCCAGCTGCA GGAGGAGCTG CGGGGCCTGA GAGAGACGTT CAGCAACTTC 
ACAGCGAGCA CGGAGGCCCA GGTCAAGGGC TTGAGCACCC AGGGAGGCAA TGTGGGAAGA 
AAGATGAAGT CGCTAGAGTC CCAGCTGGAG AAACAGCAGA AGGACCTGAG TGAAGATCAC 
TCCAGCCTGC TGCTCCACGT GAAGCAGTTC GTGTCTGACC TGCGGAGCCT GAGCTGTCAG 
ATGGCGGCGC TCCAGGGCAA TGGCTCAGAA AGGACCTGCT GCCCGGTCAA CTGGGTGGAG 
CACGAGCGCA GCTGCTACTG GTTCTCTCGC TCCGGGAAGG CCTGGGCTGA CGCCGACAAC 
TACTGCCGGC TGGAGGACGC GCACCTGGTG GTGGTCACGT CCTGGGAGGA GCAGAAATTT 
GTCCAGCACC ACATAGGCCC TGTGAACACC TGGATGGGCC TCCACGACCA AAACGGGCCC 
TGGAAGTGGG TGGACGGGAC GGACTACGAG ACGGGCTTCA AGAACTGGAG GCCGGAGCAG 
CCGGACGACT GGTACGGCCA CGGGCTCGGA GGAGGCGAGG ACTGTGCCCA CTTCACCGAC 
GACGGCCGCT GGAACGACGA CGTCTGCCAG AGGCCCTACC GCTGGGTCTG CGAGACAGAG 
CTGGACAAGG CCAGCCAGGA GCCACCTCTC CTTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ASGR1 ( NM_001197216.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001184145.1 Homo sapiens asialoglycoprotein receptor 1 (ASGR1), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu05679
Clone ID Related Accession (Same CDS sequence)	NM_001197216.2
Accession Version	NM_001197216.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 759bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Homo sapiens(human)
Product	asialoglycoprotein receptor 1 isoform b
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BQ653541.1, FJ410292.1 and BC032130.2. On Jan 19, 2011 this sequence version replaced NM_001197216.1. Transcript Variant: This variant (2), also known as H1b, lacks an in-frame exon in the 5' coding region, compared to variant 1. The encoded isoform (b) is shorter than isoform a. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR5189664.28200.1, SRR5189664.164061.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGACCAAGG AGTATCAAGA CCTTCAGCAT CTGGACAATG AGGAGAGTGA CCACCATCAG 
CTCAGAAAAG ACTCCCAGCT GCAGGAGGAG CTGCGGGGCC TGAGAGAGAC GTTCAGCAAC 
TTCACAGCGA GCACGGAGGC CCAGGTCAAG GGCTTGAGCA CCCAGGGAGG CAATGTGGGA 
AGAAAGATGA AGTCGCTAGA GTCCCAGCTG GAGAAACAGC AGAAGGACCT GAGTGAAGAT 
CACTCCAGCC TGCTGCTCCA CGTGAAGCAG TTCGTGTCTG ACCTGCGGAG CCTGAGCTGT 
CAGATGGCGG CGCTCCAGGG CAATGGCTCA GAAAGGACCT GCTGCCCGGT CAACTGGGTG 
GAGCACGAGC GCAGCTGCTA CTGGTTCTCT CGCTCCGGGA AGGCCTGGGC TGACGCCGAC 
AACTACTGCC GGCTGGAGGA CGCGCACCTG GTGGTGGTCA CGTCCTGGGA GGAGCAGAAA 
TTTGTCCAGC ACCACATAGG CCCTGTGAAC ACCTGGATGG GCCTCCACGA CCAAAACGGG 
CCCTGGAAGT GGGTGGACGG GACGGACTAC GAGACGGGCT TCAAGAACTG GAGGCCGGAG 
CAGCCGGACG ACTGGTACGG CCACGGGCTC GGAGGAGGCG AGGACTGTGC CCACTTCACC 
GACGACGGCC GCTGGAACGA CGACGTCTGC CAGAGGCCCT ACCGCTGGGT CTGCGAGACA 
GAGCTGGACA AGGCCAGCCA GGAGCCACCT CTCCTTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001184145.1
CDS	401..1159
Translation	MTKEYQDLQHLDNEESDHHQLRKDSQLQEELRGLRETFSNFTASTEAQVKGLSTQGGNVGRKMKSLESQLEKQQKDLSEDHSSLLLHVKQFVSDLRSLSCQMAALQGNGSERTCCPVNWVEHERSCYWFSRSGKAWADADNYCRLEDAHLVVVTSWEEQKFVQHHIGPVNTWMGLHDQNGPWKWVDGTDYETGFKNWRPEQPDDWYGHGLGGGEDCAHFTDDGRWNDDVCQRPYRWVCETELDKASQEPPLL

Target ORF information:

RefSeq Version	NM_001197216.2
Organism	Homo sapiens(human)
Definition	Homo sapiens asialoglycoprotein receptor 1 (ASGR1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001197216.2

ORF Insert Sequence:

ATGACCAAGG AGTATCAAGA CCTTCAGCAT CTGGACAATG AGGAGAGTGA CCACCATCAG 
CTCAGAAAAG ACTCCCAGCT GCAGGAGGAG CTGCGGGGCC TGAGAGAGAC GTTCAGCAAC 
TTCACAGCGA GCACGGAGGC CCAGGTCAAG GGCTTGAGCA CCCAGGGAGG CAATGTGGGA 
AGAAAGATGA AGTCGCTAGA GTCCCAGCTG GAGAAACAGC AGAAGGACCT GAGTGAAGAT 
CACTCCAGCC TGCTGCTCCA CGTGAAGCAG TTCGTGTCTG ACCTGCGGAG CCTGAGCTGT 
CAGATGGCGG CGCTCCAGGG CAATGGCTCA GAAAGGACCT GCTGCCCGGT CAACTGGGTG 
GAGCACGAGC GCAGCTGCTA CTGGTTCTCT CGCTCCGGGA AGGCCTGGGC TGACGCCGAC 
AACTACTGCC GGCTGGAGGA CGCGCACCTG GTGGTGGTCA CGTCCTGGGA GGAGCAGAAA 
TTTGTCCAGC ACCACATAGG CCCTGTGAAC ACCTGGATGG GCCTCCACGA CCAAAACGGG 
CCCTGGAAGT GGGTGGACGG GACGGACTAC GAGACGGGCT TCAAGAACTG GAGGCCGGAG 
CAGCCGGACG ACTGGTACGG CCACGGGCTC GGAGGAGGCG AGGACTGTGC CCACTTCACC 
GACGACGGCC GCTGGAACGA CGACGTCTGC CAGAGGCCCT ACCGCTGGGT CTGCGAGACA 
GAGCTGGACA AGGCCAGCCA GGAGCCACCT CTCCTTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Generation of an ASGR1 homozygous mutant human embryonic stem cell line WAe001-A-6 using CRISPR/Cas9.
Stem cell research2229-32(2017 Jul)
Xu Y,Wu Y,Guo D,Gao G,Lai K,Yang F,Wang K,Wu H,Lai L,Li J,Xu K,Li YX

PEGylation potentiates hepatoma cell targeted liposome-mediated in vitro gene delivery via the asialoglycoprotein receptor.
Zeitschrift fur Naturforschung. C, Journal of biosciences72(7-8)293-301(2017 Jul)
Mkhwanazi NK,de Koning CB,van Otterlo WAL,Ariatti M,Singh M

The asialoglycoprotein receptor suppresses the metastasis of hepatocellular carcinoma via LASS2-mediated inhibition of V-ATPase activity.
Cancer letters379(1)107-16(2016 08)
Gu D,Jin H,Jin G,Wang C,Wang N,Hu F,Luo Q,Chu W,Yao M,Qin W

Platelet clearance by the hepatic Ashwell-Morrell receptor: mechanisms and biological significance.
Thrombosis research141 Suppl 2S68-72(2016 May)
Hoffmeister KM,Falet H

Establishment of a functional cell line expressing both subunits of H1a and H2c of human hepatocyte surface molecule ASGPR.
Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban30(5)556-61(2010 Oct)
Hu B,Yang Y,Liu J,Ma Z,Huang H,Liu S,Yu Y,Hao Y,Wang B,Lu M,Yang D

- Most Popular Services
  - 人工遺伝子合成& DNA合成-納期保証
- Services & Products

見積依頼

Eメール

japanmarket@genscript.com

電話

03-6811-6572

FAX

03-6811-6573
050-3174-7589(受注専用)

オンラインフォーム

オンライン注文

ASGR1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Most Popular Services

Services & Products

見積依頼

Eメール

電話

FAX

オンラインフォーム

サポート

会社情報

サポート

会社情報