RGS21 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	RGS21
Entrez Gene ID	431704
Full Name	regulator of G protein signaling 21
General protein information	Preferred Names regulator of G protein signaling 21 Names regulator of G-protein signaling 21 regulator of G-protein signalling 21
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1q31.2
Summary	Regulator of G protein signaling (RGS) proteins are regulatory and structural components of G protein-coupled receptor complexes. RGS proteins are GTPase-activating proteins for Gi (see GNAI1; MIM 139310) and Gq (see GNAQ; MIM 600998) class G-alpha proteins. They accelerate transit through the cycle of GTP binding and hydrolysis and thereby accelerate signaling kinetics and termination.[supplied by OMIM, Nov 2008].
Disorder MIM:	612407

mRNA and Protein(s)

mRNA	Protein	Name
NM_001039152.3	NP_001034241.1	regulator of G-protein signaling 21

Pathways from BioSystems

Homologies

Bos taurus (cattle)	RGS21	XP_002693976.1
Mus musculus (house mouse)	Rgs21	XP_894544.3
Gallus gallus (chicken)	RGS21	XP_004943194.1
Xenopus tropicalis (tropical clawed frog)	rgs21	XP_002939123.2
Pan troglodytes (chimpanzee)	RGS21	XP_001166182.1
Canis lupus familiaris (dog)	RGS21	XP_849754.2
Rattus norvegicus (Norway rat)	LOC102551739	XP_006250037.1
	LOC712826	XP_001113001.1
Homo sapiens (human)	RGS21	NP_001034241.1
Danio rerio (zebrafish)	rgs1	XP_684009.4

Gene Ontology
Bibliography

Related articles in PubMed

Regulator of G-protein signaling-21 (RGS21) is an inhibitor of bitter gustatory signaling found in lingual and airway epithelia.
Cohen SP, Buckley BK, Kosloff M, Garland AL, Bosch DE, Cheng G Jr, Radhakrishna H, Brown MD, Willard FS, Arshavsky VY, Tarran R, Siderovski DP, Kimple AJ
The Journal of biological chemistry287(50)41706-19(2012 Dec)

Genome-wide linkage and association scans for pulse pressure in Chinese twins.
Zhang D, Pang Z, Li S, Jiang W, Wang S, Thomassen M, Hjelmborg JV, Kruse TA, Ohm Kyvik K, Christensen K, Zhu G, Tan Q
Hypertension research : official journal of the Japanese Society of Hypertension35(11)1051-7(2012 Nov)

Isolation and expression pattern of RGS21 gene, a novel RGS member.
Li X, Chen L, Ji C, Liu B, Gu J, Xu J, Zou X, Gu S, Mao Y
Acta biochimica Polonica52(4)943-6(2005)

RGS21 is a novel regulator of G protein signalling selectively expressed in subpopulations of taste bud cells.
von Buchholtz L, Elischer A, Tareilus E, Gouka R, Kaiser C, Breer H, Conzelmann S
The European journal of neuroscience19(6)1535-44(2004 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

RGS21 modulates bitter taste signal transduction.
Title: Regulator of G-protein signaling-21 (RGS21) is an inhibitor of bitter gustatory signaling found in lingual and airway epithelia.

RGS21 mRNA is expressed ubiquitously in the 16 tissues examined, implying general physiological roles.
Title: Isolation and expression pattern of RGS21 gene, a novel RGS member.

The following RGS21 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the RGS21 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu10622	NM_001039152.3 Latest version!	Homo sapiens regulator of G protein signaling 21 (RGS21), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

RGS21 ( NM_001039152.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001034241.1 Homo sapiens regulator of G protein signaling 21 (RGS21), mRNA.

Price & Availability↑

CloneID	OHu10622
Clone ID Related Accession (Same CDS sequence)	NM_001039152.3
Accession Version	NM_001039152.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 459bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-06-29
Organism	Homo sapiens(human)
Product	regulator of G-protein signaling 21
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AY643711.1, AL357566.12 and AL390957.14. On Jan 28, 2010 this sequence version replaced NM_001039152.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: AY643711.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000417209.2/ ENSP00000428343.1 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGCCAGTGA AATGCTGTTT CTACAGGTCA CCAACTGCGG AAACAATGAC ATGGTCTGAA 
AATATGGACA CGCTTTTAGC CAACCAAGCT GGTCTAGATG CTTTTCGAAT ATTTCTAAAA 
TCAGAGTTTA GTGAAGAAAA TGTTGAGTTC TGGCTTGCCT GTGAAGACTT TAAGAAAACG 
AAAAATGCAG ACAAAATTGC TTCCAAAGCC AAGATGATTT ATTCTGAATT CATTGAAGCT 
GATGCACCTA AAGAGATTAA CATTGACTTC GGTACCAGAG ACCTCATCTC AAAGAATATT 
GCTGAACCAA CACTCAAATG CTTTGATGAG GCTCAGAAAT TAATCTATTG TCTCATGGCC 
AAGGATTCTT TCCCTCGATT TCTGAAGTCA GAGATTTATA AAAAACTGGT AAATAGCCAA 
CAGGTTCCAA ATCATAAAAA ATGGCTCCCT TTTTTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001034241.1
CDS	175..633
Translation	MPVKCCFYRSPTAETMTWSENMDTLLANQAGLDAFRIFLKSEFSEENVEFWLACEDFKKTKNADKIASKAKMIYSEFIEADAPKEINIDFGTRDLISKNIAEPTLKCFDEAQKLIYCLMAKDSFPRFLKSEIYKKLVNSQQVPNHKKWLPFL

Target ORF information:

RefSeq Version	NM_001039152.3
Organism	Homo sapiens(human)
Definition	Homo sapiens regulator of G protein signaling 21 (RGS21), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001039152.3

ORF Insert Sequence:

ATGCCAGTGA AATGCTGTTT CTACAGGTCA CCAACTGCGG AAACAATGAC ATGGTCTGAA 
AATATGGACA CGCTTTTAGC CAACCAAGCT GGTCTAGATG CTTTTCGAAT ATTTCTAAAA 
TCAGAGTTTA GTGAAGAAAA TGTTGAGTTC TGGCTTGCCT GTGAAGACTT TAAGAAAACG 
AAAAATGCAG ACAAAATTGC TTCCAAAGCC AAGATGATTT ATTCTGAATT CATTGAAGCT 
GATGCACCTA AAGAGATTAA CATTGACTTC GGTACCAGAG ACCTCATCTC AAAGAATATT 
GCTGAACCAA CACTCAAATG CTTTGATGAG GCTCAGAAAT TAATCTATTG TCTCATGGCC 
AAGGATTCTT TCCCTCGATT TCTGAAGTCA GAGATTTATA AAAAACTGGT AAATAGCCAA 
CAGGTTCCAA ATCATAAAAA ATGGCTCCCT TTTTTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Regulator of G-protein signaling-21 (RGS21) is an inhibitor of bitter gustatory signaling found in lingual and airway epithelia.
The Journal of biological chemistry287(50)41706-19(2012 Dec)
Cohen SP,Buckley BK,Kosloff M,Garland AL,Bosch DE,Cheng G Jr,Radhakrishna H,Brown MD,Willard FS,Arshavsky VY,Tarran R,Siderovski DP,Kimple AJ

Genome-wide linkage and association scans for pulse pressure in Chinese twins.
Hypertension research : official journal of the Japanese Society of Hypertension35(11)1051-7(2012 Nov)
Zhang D,Pang Z,Li S,Jiang W,Wang S,Thomassen M,Hjelmborg JV,Kruse TA,Ohm Kyvik K,Christensen K,Zhu G,Tan Q

Isolation and expression pattern of RGS21 gene, a novel RGS member.
Acta biochimica Polonica52(4)943-6(2005)
Li X,Chen L,Ji C,Liu B,Gu J,Xu J,Zou X,Gu S,Mao Y

RGS21 is a novel regulator of G protein signalling selectively expressed in subpopulations of taste bud cells.
The European journal of neuroscience19(6)1535-44(2004 Mar)
von Buchholtz L,Elischer A,Tareilus E,Gouka R,Kaiser C,Breer H,Conzelmann S

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RGS21 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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