MLN cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	MLN
Entrez Gene ID	4295
Full Name	motilin
General protein information	Preferred Names motilin Names promotilin prepromotilin
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 6 Map Location: 6p21.31
Summary	This gene encodes a small peptide hormone that is secreted by cells of the small intestine to regulate gastrointestinal contractions and motility. Proteolytic processing of the secreted protein produces the mature peptide and a byproduct referred to as motilin-associated peptide (MAP). Three transcript variants encoding different preproprotein isoforms but the same mature peptide have been found for this gene. [provided by RefSeq, May 2010].
Disorder MIM:	158270

mRNA and Protein(s)

mRNA	Protein	Name
NM_001040109.1	NP_001035198.1	promotilin isoform 2 preproprotein
NM_001040109.2	NP_001035198.1	promotilin isoform 2 preproprotein
NM_002418.2	NP_002409.1	promotilin isoform 1 preproprotein
NM_002418.3	NP_002409.1	promotilin isoform 1 preproprotein
NM_001184698.1	NP_001171627.1	promotilin isoform 3 preproprotein
NM_001184698.2	NP_001171627.1	promotilin isoform 3 preproprotein

Pathways from BioSystems

Homologies

Bos taurus (cattle)	MLN	NP_776363.1
Homo sapiens (human)	MLN	NP_002409.1
Canis lupus familiaris (dog)	MLN	XP_005627282.1
Pan troglodytes (chimpanzee)	MLN	XP_001171525.1
	MLN	NP_001027979.1

Gene Ontology
Bibliography

Related articles in PubMed

Circulating motilin, ghrelin, and GLP-1 and their correlations with gastric slow waves in patients with chronic kidney disease.
Wu GJ, Cai XD, Xing J, Zhong GH, Chen JDZ
American journal of physiology. Regulatory, integrative and comparative physiology313(2)R149-R157(2017 Aug)

Redefining the functional roles of the gastrointestinal migrating motor complex and motilin in small bacterial overgrowth and hunger signaling.
Deloose E, Tack J
American journal of physiology. Gastrointestinal and liver physiology310(4)G228-33(2016 Feb)

Genome-wide association study of Crohn's disease in Koreans revealed three new susceptibility loci and common attributes of genetic susceptibility across ethnic populations.
Yang SK, Hong M, Zhao W, Jung Y, Baek J, Tayebi N, Kim KM, Ye BD, Kim KJ, Park SH, Lee I, Lee EJ, Kim WH, Cheon JH, Kim YH, Jang BI, Kim HS, Choi JH, Koo JS, Lee JH, Jung SA, Lee YJ, Jang JY, Shin HD, Kang D, Youn HS, Liu J, Song K
Gut63(1)80-7(2014 Jan)

Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
Comuzzie AG, Cole SA, Laston SL, Voruganti VS, Haack K, Gibbs RA, Butte NF
PloS one7(12)e51954(2012)

Ghrelin and motilin in the gastrointestinal system.
Chen CY, Tsai CY
Current pharmaceutical design18(31)4755-65(2012)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Hemodialysis improves upper GI symptoms and gastric slow waves in CKD patients. An increase in ghrelin and a decrease in GLP-1 might be involved in the HD-induced improvement in gastric slow waves.
Title: Circulating motilin, ghrelin, and GLP-1 and their correlations with gastric slow waves in patients with chronic kidney disease.

motilin-induced phase III contractions signal hunger in healthy subjects and that this system is disturbed in morbidly obese patients--{REVIEW}
Title: Redefining the functional roles of the gastrointestinal migrating motor complex and motilin in small bacterial overgrowth and hunger signaling.

Motilin stimulates growth hormone secretion and regulates interdigestive migrating contractions and fasting motor patterns in the gastrointestinal tract. [REVIEW]
Title: Ghrelin and motilin in the gastrointestinal system.

Motilin may directly influence adipocyte functions by stimulating energy storage.
Title: Motilin stimulates preadipocyte proliferation and differentiation and adipocyte lipid storage.

Ghrelin covaried with motilin in plasma in irritable bowel syndrome (IBS) but not in plasma from healthy subjects. This suggests the two peptides act together in IBS.
Title: Covariation of plasma ghrelin and motilin in irritable bowel syndrome.

The following MLN gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MLN cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu55611	NM_002418.3 Latest version!	Homo sapiens motilin (MLN), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu00227	NM_001184698.2 Latest version!	Homo sapiens motilin (MLN), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu55769	NM_001040109.2 Latest version!	Homo sapiens motilin (MLN), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
View Old Accession Versions >>
OHu55769	NM_001040109.1	Homo sapiens motilin (MLN), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu55611	NM_002418.2	Homo sapiens motilin (MLN), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu00227	NM_001184698.1	Homo sapiens motilin (MLN), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

MLN ( NM_002418.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_002409.1 Homo sapiens motilin (MLN), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu55611
Clone ID Related Accession (Same CDS sequence)	NM_002418.2 , NM_002418.3
Accession Version	NM_002418.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 348bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-09
Organism	Homo sapiens(human)
Product	promotilin isoform 1 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL138889.9, BC069675.1, Y00695.1 and AL158049.11. On Apr 14, 2006 this sequence version replaced NM_002418.1. Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: Y00695.1, BC069675.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2144835 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

ATGGTATCCC GTAAGGCTGT GGCTGCTCTG CTGGTGGTGC ATGTAGCTGC CATGCTGGCC 
TCCCAGACGG AAGCCTTCGT CCCCATCTTC ACCTATGGCG AACTCCAGAG GATGCAGGAA 
AAGGAACGGA ATAAAGGGCA AAAGAAATCC CTGAGTGTAT GGCAGAGGTC TGGGGAGGAA 
GGTCCTGTAG ACCCTGCGGA GCCCATCAGG GAAGAAGAAA ACGAAATGAT CAAGCTGACT 
GCTCCTCTGG AAATTGGAAT GAGGATGAAC TCCAGACAGC TGGAAAAGTA CCCGGCCACC 
CTGGAAGGGC TGCTGAGTGA GATGCTTCCC CAGCATGCAG CCAAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002409.1
CDS	72..419
Translation	MVSRKAVAALLVVHVAAMLASQTEAFVPIFTYGELQRMQEKERNKGQKKSLSVWQRSGEEGPVDPAEPIREEENEMIKLTAPLEIGMRMNSRQLEKYPATLEGLLSEMLPQHAAK

Target ORF information:

RefSeq Version	NM_002418.2
Organism	Homo sapiens(human)
Definition	Homo sapiens motilin (MLN), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002418.2

ORF Insert Sequence:

ATGGTATCCC GTAAGGCTGT GGCTGCTCTG CTGGTGGTGC ATGTAGCTGC CATGCTGGCC 
TCCCAGACGG AAGCCTTCGT CCCCATCTTC ACCTATGGCG AACTCCAGAG GATGCAGGAA 
AAGGAACGGA ATAAAGGGCA AAAGAAATCC CTGAGTGTAT GGCAGAGGTC TGGGGAGGAA 
GGTCCTGTAG ACCCTGCGGA GCCCATCAGG GAAGAAGAAA ACGAAATGAT CAAGCTGACT 
GCTCCTCTGG AAATTGGAAT GAGGATGAAC TCCAGACAGC TGGAAAAGTA CCCGGCCACC 
CTGGAAGGGC TGCTGAGTGA GATGCTTCCC CAGCATGCAG CCAAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MLN ( NM_002418.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_002409.1 Homo sapiens motilin (MLN), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu55611
Clone ID Related Accession (Same CDS sequence)	NM_002418.2 , NM_002418.3
Accession Version	NM_002418.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 348bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-30
Organism	Homo sapiens(human)
Product	promotilin isoform 1 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC069675.1, Y00695.1 and AL158049.11. On Nov 23, 2018 this sequence version replaced NM_002418.2. Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: Y00695.1, BC069675.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2144835 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000430124.7/ ENSP00000388825.2 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGTATCCC GTAAGGCTGT GGCTGCTCTG CTGGTGGTGC ATGTAGCTGC CATGCTGGCC 
TCCCAGACGG AAGCCTTCGT CCCCATCTTC ACCTATGGCG AACTCCAGAG GATGCAGGAA 
AAGGAACGGA ATAAAGGGCA AAAGAAATCC CTGAGTGTAT GGCAGAGGTC TGGGGAGGAA 
GGTCCTGTAG ACCCTGCGGA GCCCATCAGG GAAGAAGAAA ACGAAATGAT CAAGCTGACT 
GCTCCTCTGG AAATTGGAAT GAGGATGAAC TCCAGACAGC TGGAAAAGTA CCCGGCCACC 
CTGGAAGGGC TGCTGAGTGA GATGCTTCCC CAGCATGCAG CCAAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002409.1
CDS	59..406
Translation	MVSRKAVAALLVVHVAAMLASQTEAFVPIFTYGELQRMQEKERNKGQKKSLSVWQRSGEEGPVDPAEPIREEENEMIKLTAPLEIGMRMNSRQLEKYPATLEGLLSEMLPQHAAK

Target ORF information:

RefSeq Version	NM_002418.3
Organism	Homo sapiens(human)
Definition	Homo sapiens motilin (MLN), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002418.3

ORF Insert Sequence:

ATGGTATCCC GTAAGGCTGT GGCTGCTCTG CTGGTGGTGC ATGTAGCTGC CATGCTGGCC 
TCCCAGACGG AAGCCTTCGT CCCCATCTTC ACCTATGGCG AACTCCAGAG GATGCAGGAA 
AAGGAACGGA ATAAAGGGCA AAAGAAATCC CTGAGTGTAT GGCAGAGGTC TGGGGAGGAA 
GGTCCTGTAG ACCCTGCGGA GCCCATCAGG GAAGAAGAAA ACGAAATGAT CAAGCTGACT 
GCTCCTCTGG AAATTGGAAT GAGGATGAAC TCCAGACAGC TGGAAAAGTA CCCGGCCACC 
CTGGAAGGGC TGCTGAGTGA GATGCTTCCC CAGCATGCAG CCAAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MLN ( NM_001184698.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001171627.1 Homo sapiens motilin (MLN), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu00227
Clone ID Related Accession (Same CDS sequence)	NM_001184698.1 , NM_001184698.2
Accession Version	NM_001184698.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 327bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-21
Organism	Homo sapiens(human)
Product	promotilin isoform 3 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL138889.9, BC143981.1, Y00695.1 and AL158049.11. Transcript Variant: This variant (3) uses an alternate in-frame splice junction at the 3' end of an exon compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC143981.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA2142586, SAMEA2144835 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: full length.

ATGGTATCCC GTAAGGCTGT GGCTGCTCTG CTGGTGGTGC ATGTAGCTGC CATGCTGGCC 
TCCCAGACGG AAGCCTTCGT CCCCATCTTC ACCTATGGCG AACTCCAGAG GATGCAGGAA 
AAGGAACGGA ATAAAGGGCA AAAGAAATCC CTGAGTGTAT GGCAGAGGTC TGGGGAGGAA 
GGTCCTGTAG ACCCTGCGGA GCCCATCAGG GAAGAAGAAA ACGAAATGAT CAAGCTGACT 
GCTCCTCTGG AAATTGGAAT GAGGATGAAC TCCAGACAGC TGGAAAAGTA CCCGGCCACC 
CTGGAAGGGC TGCTGACAGC CAAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001171627.1
CDS	72..398
Translation	MVSRKAVAALLVVHVAAMLASQTEAFVPIFTYGELQRMQEKERNKGQKKSLSVWQRSGEEGPVDPAEPIREEENEMIKLTAPLEIGMRMNSRQLEKYPATLEGLLTAK

Target ORF information:

RefSeq Version	NM_001184698.1
Organism	Homo sapiens(human)
Definition	Homo sapiens motilin (MLN), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001184698.1

ORF Insert Sequence:

ATGGTATCCC GTAAGGCTGT GGCTGCTCTG CTGGTGGTGC ATGTAGCTGC CATGCTGGCC 
TCCCAGACGG AAGCCTTCGT CCCCATCTTC ACCTATGGCG AACTCCAGAG GATGCAGGAA 
AAGGAACGGA ATAAAGGGCA AAAGAAATCC CTGAGTGTAT GGCAGAGGTC TGGGGAGGAA 
GGTCCTGTAG ACCCTGCGGA GCCCATCAGG GAAGAAGAAA ACGAAATGAT CAAGCTGACT 
GCTCCTCTGG AAATTGGAAT GAGGATGAAC TCCAGACAGC TGGAAAAGTA CCCGGCCACC 
CTGGAAGGGC TGCTGACAGC CAAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MLN ( NM_001184698.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001171627.1 Homo sapiens motilin (MLN), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu00227
Clone ID Related Accession (Same CDS sequence)	NM_001184698.1 , NM_001184698.2
Accession Version	NM_001184698.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 327bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-30
Organism	Homo sapiens(human)
Product	promotilin isoform 3 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL138889.9, BC143981.1, Y00695.1 and AL158049.11. On May 31, 2019 this sequence version replaced NM_001184698.1. Transcript Variant: This variant (3) uses an alternate in-frame splice junction at the 3' end of an exon compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC143981.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA2142586, SAMEA2144835 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: full length.

ATGGTATCCC GTAAGGCTGT GGCTGCTCTG CTGGTGGTGC ATGTAGCTGC CATGCTGGCC 
TCCCAGACGG AAGCCTTCGT CCCCATCTTC ACCTATGGCG AACTCCAGAG GATGCAGGAA 
AAGGAACGGA ATAAAGGGCA AAAGAAATCC CTGAGTGTAT GGCAGAGGTC TGGGGAGGAA 
GGTCCTGTAG ACCCTGCGGA GCCCATCAGG GAAGAAGAAA ACGAAATGAT CAAGCTGACT 
GCTCCTCTGG AAATTGGAAT GAGGATGAAC TCCAGACAGC TGGAAAAGTA CCCGGCCACC 
CTGGAAGGGC TGCTGACAGC CAAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001171627.1
CDS	59..385
Translation	MVSRKAVAALLVVHVAAMLASQTEAFVPIFTYGELQRMQEKERNKGQKKSLSVWQRSGEEGPVDPAEPIREEENEMIKLTAPLEIGMRMNSRQLEKYPATLEGLLTAK

Target ORF information:

RefSeq Version	NM_001184698.2
Organism	Homo sapiens(human)
Definition	Homo sapiens motilin (MLN), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001184698.2

ORF Insert Sequence:

ATGGTATCCC GTAAGGCTGT GGCTGCTCTG CTGGTGGTGC ATGTAGCTGC CATGCTGGCC 
TCCCAGACGG AAGCCTTCGT CCCCATCTTC ACCTATGGCG AACTCCAGAG GATGCAGGAA 
AAGGAACGGA ATAAAGGGCA AAAGAAATCC CTGAGTGTAT GGCAGAGGTC TGGGGAGGAA 
GGTCCTGTAG ACCCTGCGGA GCCCATCAGG GAAGAAGAAA ACGAAATGAT CAAGCTGACT 
GCTCCTCTGG AAATTGGAAT GAGGATGAAC TCCAGACAGC TGGAAAAGTA CCCGGCCACC 
CTGGAAGGGC TGCTGACAGC CAAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MLN ( NM_001040109.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001035198.1 Homo sapiens motilin (MLN), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu55769
Clone ID Related Accession (Same CDS sequence)	NM_001040109.1 , NM_001040109.2
Accession Version	NM_001040109.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 345bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-16
Organism	Homo sapiens(human)
Product	promotilin isoform 2 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL138889.9, BC069675.1, Y00695.1 and AW014210.1. Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1, resulting in a shorter preproprotein (isoform 2) but not affecting the mature peptide. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMEA2144835 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

ATGGTATCCC GTAAGGCTGT GGCTGCTCTG CTGGTGGTGC ATGTAGCTGC CATGCTGGCC 
TCCCAGACGG AAGCCTTCGT CCCCATCTTC ACCTATGGCG AACTCCAGAG GATGCAGGAA 
AAGGAACGGA ATAAAGGGCA AAAGAAATCC CTGAGTGTAT GGCAGAGGTC TGGGGAGGAA 
GGTCCTGTAG ACCCTGCGGA GCCCATCAGG GAAGAAGAAA ACGAAATGAT CAAGCTGACT 
GCTCCTCTGG AAATTGGAAT GAGGATGAAC TCCAGACAGC TGGAAAAGTA CCCGGCCACC 
CTGGAAGGGC TGCTGAGTGA GATGCTTCCC CAGCATGCCA AGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001035198.1
CDS	72..416
Translation	MVSRKAVAALLVVHVAAMLASQTEAFVPIFTYGELQRMQEKERNKGQKKSLSVWQRSGEEGPVDPAEPIREEENEMIKLTAPLEIGMRMNSRQLEKYPATLEGLLSEMLPQHAK

Target ORF information:

RefSeq Version	NM_001040109.1
Organism	Homo sapiens(human)
Definition	Homo sapiens motilin (MLN), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001040109.1

ORF Insert Sequence:

ATGGTATCCC GTAAGGCTGT GGCTGCTCTG CTGGTGGTGC ATGTAGCTGC CATGCTGGCC 
TCCCAGACGG AAGCCTTCGT CCCCATCTTC ACCTATGGCG AACTCCAGAG GATGCAGGAA 
AAGGAACGGA ATAAAGGGCA AAAGAAATCC CTGAGTGTAT GGCAGAGGTC TGGGGAGGAA 
GGTCCTGTAG ACCCTGCGGA GCCCATCAGG GAAGAAGAAA ACGAAATGAT CAAGCTGACT 
GCTCCTCTGG AAATTGGAAT GAGGATGAAC TCCAGACAGC TGGAAAAGTA CCCGGCCACC 
CTGGAAGGGC TGCTGAGTGA GATGCTTCCC CAGCATGCCA AGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MLN ( NM_001040109.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001035198.1 Homo sapiens motilin (MLN), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu55769
Clone ID Related Accession (Same CDS sequence)	NM_001040109.1 , NM_001040109.2
Accession Version	NM_001040109.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 345bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-30
Organism	Homo sapiens(human)
Product	promotilin isoform 2 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC069675.1, Y00695.1 and AW014210.1. On May 31, 2019 this sequence version replaced NM_001040109.1. Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1, resulting in a shorter preproprotein (isoform 2) but not affecting the mature peptide. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## CDS exon combination :: AW014210.1, AI824815.1 [ECO:0000331] RNAseq introns :: single sample supports all introns SAMEA2144835 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

ATGGTATCCC GTAAGGCTGT GGCTGCTCTG CTGGTGGTGC ATGTAGCTGC CATGCTGGCC 
TCCCAGACGG AAGCCTTCGT CCCCATCTTC ACCTATGGCG AACTCCAGAG GATGCAGGAA 
AAGGAACGGA ATAAAGGGCA AAAGAAATCC CTGAGTGTAT GGCAGAGGTC TGGGGAGGAA 
GGTCCTGTAG ACCCTGCGGA GCCCATCAGG GAAGAAGAAA ACGAAATGAT CAAGCTGACT 
GCTCCTCTGG AAATTGGAAT GAGGATGAAC TCCAGACAGC TGGAAAAGTA CCCGGCCACC 
CTGGAAGGGC TGCTGAGTGA GATGCTTCCC CAGCATGCCA AGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001035198.1
CDS	59..403
Translation	MVSRKAVAALLVVHVAAMLASQTEAFVPIFTYGELQRMQEKERNKGQKKSLSVWQRSGEEGPVDPAEPIREEENEMIKLTAPLEIGMRMNSRQLEKYPATLEGLLSEMLPQHAK

Target ORF information:

RefSeq Version	NM_001040109.2
Organism	Homo sapiens(human)
Definition	Homo sapiens motilin (MLN), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001040109.2

ORF Insert Sequence:

ATGGTATCCC GTAAGGCTGT GGCTGCTCTG CTGGTGGTGC ATGTAGCTGC CATGCTGGCC 
TCCCAGACGG AAGCCTTCGT CCCCATCTTC ACCTATGGCG AACTCCAGAG GATGCAGGAA 
AAGGAACGGA ATAAAGGGCA AAAGAAATCC CTGAGTGTAT GGCAGAGGTC TGGGGAGGAA 
GGTCCTGTAG ACCCTGCGGA GCCCATCAGG GAAGAAGAAA ACGAAATGAT CAAGCTGACT 
GCTCCTCTGG AAATTGGAAT GAGGATGAAC TCCAGACAGC TGGAAAAGTA CCCGGCCACC 
CTGGAAGGGC TGCTGAGTGA GATGCTTCCC CAGCATGCCA AGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Circulating motilin, ghrelin, and GLP-1 and their correlations with gastric slow waves in patients with chronic kidney disease.
American journal of physiology. Regulatory, integrative and comparative physiology313(2)R149-R157(2017 Aug)
Wu GJ,Cai XD,Xing J,Zhong GH,Chen JDZ

Redefining the functional roles of the gastrointestinal migrating motor complex and motilin in small bacterial overgrowth and hunger signaling.
American journal of physiology. Gastrointestinal and liver physiology310(4)G228-33(2016 Feb)
Deloose E,Tack J

Genome-wide association study of Crohn's disease in Koreans revealed three new susceptibility loci and common attributes of genetic susceptibility across ethnic populations.
Gut63(1)80-7(2014 Jan)
Yang SK,Hong M,Zhao W,Jung Y,Baek J,Tayebi N,Kim KM,Ye BD,Kim KJ,Park SH,Lee I,Lee EJ,Kim WH,Cheon JH,Kim YH,Jang BI,Kim HS,Choi JH,Koo JS,Lee JH,Jung SA,Lee YJ,Jang JY,Shin HD,Kang D,Youn HS,Liu J,Song K

Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
PloS one7(12)e51954(2012)
Comuzzie AG,Cole SA,Laston SL,Voruganti VS,Haack K,Gibbs RA,Butte NF

Ghrelin and motilin in the gastrointestinal system.
Current pharmaceutical design18(31)4755-65(2012)
Chen CY,Tsai CY

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MLN cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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