VCX3B cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	VCX3B
Entrez Gene ID	425054
Full Name	variable charge, X-linked 3B
Synonyms	VCX-C,VCXC
General protein information	Preferred Names variable charge, X-linked 3B Names variable charge X-linked protein 3B variably charged protein X-C
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: X Map Location: Xp22.31
Summary	This gene belongs to the VCX/Y gene family, which has multiple members on both X and Y chromosomes, and all are expressed exclusively in male germ cells. The X-linked members are clustered on chromosome Xp22, and the Y-linked members are two identical copies of the gene within a palindromic region on chromosome Yq11. The family members share a high degree of sequence identity, with the exception that a 30-nt unit is tandemly repeated in X-linked members but occurs only once in Y-linked members. The VCX gene cluster is polymorphic in terms of copy number; different individuals may have a different number of VCX genes. This family member, as represented by the reference genome allele, contains 14 copies of the 30-nt repeat unit. VCX/Y genes encode small and highly charged proteins containing putative bipartite nuclear localization signals. Although the exact function of this family member has yet to be determined, a role in mRNA stability regulation can be inferred from the ability of the highly similar family member, VCX-A, to inhibit mRNA decapping. A possible role in the regulation of ribosome assembly during spermatogenesis has also been suggested. [provided by RefSeq, Aug 2010].
Disorder MIM:	300981

mRNA and Protein(s)

mRNA	Protein	Name
NM_001001888.3	NP_001001888.3	variable charge X-linked protein 3B
NM_001001888.4	NP_001001888.3	variable charge X-linked protein 3B

Pathways from BioSystems

Homologies

Homo sapiens (human)	VCX3B	NP_001001888.3
Pan troglodytes (chimpanzee)	LOC751066	XP_003953974.1

Gene Ontology
Bibliography

Related articles in PubMed

A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB.
Need AC, Attix DK, McEvoy JM, Cirulli ET, Linney KL, Hunt P, Ge D, Heinzen EL, Maia JM, Shianna KV, Weale ME, Cherkas LF, Clement G, Spector TD, Gibson G, Goldstein DB
Human molecular genetics18(23)4650-61(2009 Dec)

Modulation of neuritogenesis by a protein implicated in X-linked mental retardation.
Jiao X, Chen H, Chen J, Herrup K, Firestein BL, Kiledjian M
The Journal of neuroscience : the official journal of the Society for Neuroscience29(40)12419-27(2009 Oct)

Analysis of the VCX3A, VCX2 and VCX3B genes shows that VCX3A gene deletion is not sufficient to result in mental retardation in X-linked ichthyosis.
Cuevas-Covarrubias SA, Gonz?lez-Huerta LM
The British journal of dermatology158(3)483-6(2008 Mar)

A shared promoter region suggests a common ancestor for the human VCX/Y, SPANX, and CSAG gene families and the murine CYPT family.
Hansen MA, Nielsen JE, Retelska D, Larsen N, Leffers H
Molecular reproduction and development75(2)219-29(2008 Feb)

Molecular cytogenetic analysis of a familial interstitial deletion Xp22.2-22.3 with a highly variable phenotype in female carriers.
Chocholska S, Rossier E, Barbi G, Kehrer-Sawatzki H
American journal of medical genetics. Part A140(6)604-10(2006 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following VCX3B gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the VCX3B cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu21270	NM_001001888.4 Latest version!	Homo sapiens variable charge X-linked 3B (VCX3B), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$139.30 $199.00
View Old Accession Versions >>
OHu21270	NM_001001888.3	Homo sapiens variable charge X-linked 3B (VCX3B), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$139.30 $199.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

VCX3B ( NM_001001888.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001001888.3 Homo sapiens variable charge X-linked 3B (VCX3B), mRNA.

Price & Availability↑

CloneID	OHu21270
Clone ID Related Accession (Same CDS sequence)	NM_001001888.3 , NM_001001888.4
Accession Version	NM_001001888.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 741bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-06-23
Organism	Homo sapiens(human)
Product	variable charge X-linked protein 3B
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF167080.2, BC098143.1, AC006062.5 and AA883225.1. On Aug 11, 2010 this sequence version replaced NM_001001888.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMEA2159080, SAMEA2161674 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAGTCCAA AGCCGAGAGC CTCGGGACCT CCGGCCAAGG CCAAGGAGGC AGGAAAGAGG 
AAGTCCTCCT CTCAGCCGAG CCCCAGTGAC CCGAAGAAGA AGACTACCAA GGTGGCCAAG 
AAGGGAAAAG CAGTTCGTAG AGGGAGACGC GGGAAGAAAG GGGCTGCGAC AAAGATGGCG 
GCCGTGACGG CACCTGAGGC GGAGAGCGGG CCAGCGGCAC CCGGCCCCAG CGACCAGCCC 
AGCCAGGAGC TCCCTCAGCA CGAGCTGCCG CCGGAGGAGC CAGTGAGCGA GGGGACCCAG 
CACGACCCCC TGAGTCAGGA GAGCGAGCTG GAGGAACCAC TGAGTCAGGA GAGCGAGGTG 
GAAGAACCAC TGAGTCAGGA GAGCCAGGTG GAGGAACCAC TGAGTCAGGA GAGCGAGGTG 
GAAGAACCAC TGAGTCAGGA GAGCCAGGTG GAGGAACCAC TGAGTCAGGA GAGCGAGGTG 
GAGGAACCAC TGAGTCAGGA GAGCGAGGTG GAAGAACCAC TGAGTCAGGA GAGCCAGGTG 
GAGGAACCAC TGAGTCAGGA GAGCGAGGTG GAAGAACCAC TGAGTCAGGA GAGCCAGGTG 
GAGGAACCAC TGAGTCAGGA GAGCGAGATG GAAGAACCAC TGAGTCAGGA GAGCCAGGTG 
GAGGAACCAC TGAGTCAGGA GAGCGAGATG GAAGAACCAC TGAGTCAGGA GAGCGAGATG 
GAAGAACTAC CGAGTGTGTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001001888.3
CDS	308..1048
Translation	MSPKPRASGPPAKAKEAGKRKSSSQPSPSDPKKKTTKVAKKGKAVRRGRRGKKGAATKMAAVTAPEAESGPAAPGPSDQPSQELPQHELPPEEPVSEGTQHDPLSQESELEEPLSQESEVEEPLSQESQVEEPLSQESEVEEPLSQESQVEEPLSQESEVEEPLSQESEVEEPLSQESQVEEPLSQESEVEEPLSQESQVEEPLSQESEMEEPLSQESQVEEPLSQESEMEEPLSQESEMEELPSV

Target ORF information:

RefSeq Version	NM_001001888.3
Organism	Homo sapiens(human)
Definition	Homo sapiens variable charge X-linked 3B (VCX3B), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001001888.3

ORF Insert Sequence:

ATGAGTCCAA AGCCGAGAGC CTCGGGACCT CCGGCCAAGG CCAAGGAGGC AGGAAAGAGG 
AAGTCCTCCT CTCAGCCGAG CCCCAGTGAC CCGAAGAAGA AGACTACCAA GGTGGCCAAG 
AAGGGAAAAG CAGTTCGTAG AGGGAGACGC GGGAAGAAAG GGGCTGCGAC AAAGATGGCG 
GCCGTGACGG CACCTGAGGC GGAGAGCGGG CCAGCGGCAC CCGGCCCCAG CGACCAGCCC 
AGCCAGGAGC TCCCTCAGCA CGAGCTGCCG CCGGAGGAGC CAGTGAGCGA GGGGACCCAG 
CACGACCCCC TGAGTCAGGA GAGCGAGCTG GAGGAACCAC TGAGTCAGGA GAGCGAGGTG 
GAAGAACCAC TGAGTCAGGA GAGCCAGGTG GAGGAACCAC TGAGTCAGGA GAGCGAGGTG 
GAAGAACCAC TGAGTCAGGA GAGCCAGGTG GAGGAACCAC TGAGTCAGGA GAGCGAGGTG 
GAGGAACCAC TGAGTCAGGA GAGCGAGGTG GAAGAACCAC TGAGTCAGGA GAGCCAGGTG 
GAGGAACCAC TGAGTCAGGA GAGCGAGGTG GAAGAACCAC TGAGTCAGGA GAGCCAGGTG 
GAGGAACCAC TGAGTCAGGA GAGCGAGATG GAAGAACCAC TGAGTCAGGA GAGCCAGGTG 
GAGGAACCAC TGAGTCAGGA GAGCGAGATG GAAGAACCAC TGAGTCAGGA GAGCGAGATG 
GAAGAACTAC CGAGTGTGTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

VCX3B ( NM_001001888.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_001001888.3 Homo sapiens variable charge X-linked 3B (VCX3B), mRNA.

Price & Availability↑

CloneID	OHu21270
Clone ID Related Accession (Same CDS sequence)	NM_001001888.3 , NM_001001888.4
Accession Version	NM_001001888.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 741bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-06-29
Organism	Homo sapiens(human)
Product	variable charge X-linked protein 3B
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF167080.2, BC098143.1, AC006062.5 and AA883225.1. On May 17, 2019 this sequence version replaced NM_001001888.3. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## CDS exon combination :: ERR279864.2365.1, HY028987.1 [ECO:0000331] RNAseq introns :: single sample supports all introns SAMEA2159080, SAMEA2161674 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000381032.6/ ENSP00000370420.1 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGAGTCCAA AGCCGAGAGC CTCGGGACCT CCGGCCAAGG CCAAGGAGGC AGGAAAGAGG 
AAGTCCTCCT CTCAGCCGAG CCCCAGTGAC CCGAAGAAGA AGACTACCAA GGTGGCCAAG 
AAGGGAAAAG CAGTTCGTAG AGGGAGACGC GGGAAGAAAG GGGCTGCGAC AAAGATGGCG 
GCCGTGACGG CACCTGAGGC GGAGAGCGGG CCAGCGGCAC CCGGCCCCAG CGACCAGCCC 
AGCCAGGAGC TCCCTCAGCA CGAGCTGCCG CCGGAGGAGC CAGTGAGCGA GGGGACCCAG 
CACGACCCCC TGAGTCAGGA GAGCGAGCTG GAGGAACCAC TGAGTCAGGA GAGCGAGGTG 
GAAGAACCAC TGAGTCAGGA GAGCCAGGTG GAGGAACCAC TGAGTCAGGA GAGCGAGGTG 
GAAGAACCAC TGAGTCAGGA GAGCCAGGTG GAGGAACCAC TGAGTCAGGA GAGCGAGGTG 
GAGGAACCAC TGAGTCAGGA GAGCGAGGTG GAAGAACCAC TGAGTCAGGA GAGCCAGGTG 
GAGGAACCAC TGAGTCAGGA GAGCGAGGTG GAAGAACCAC TGAGTCAGGA GAGCCAGGTG 
GAGGAACCAC TGAGTCAGGA GAGCGAGATG GAAGAACCAC TGAGTCAGGA GAGCCAGGTG 
GAGGAACCAC TGAGTCAGGA GAGCGAGATG GAAGAACCAC TGAGTCAGGA GAGCGAGATG 
GAAGAACTAC CGAGTGTGTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001001888.3
CDS	308..1048
Translation	MSPKPRASGPPAKAKEAGKRKSSSQPSPSDPKKKTTKVAKKGKAVRRGRRGKKGAATKMAAVTAPEAESGPAAPGPSDQPSQELPQHELPPEEPVSEGTQHDPLSQESELEEPLSQESEVEEPLSQESQVEEPLSQESEVEEPLSQESQVEEPLSQESEVEEPLSQESEVEEPLSQESQVEEPLSQESEVEEPLSQESQVEEPLSQESEMEEPLSQESQVEEPLSQESEMEEPLSQESEMEELPSV

Target ORF information:

RefSeq Version	NM_001001888.4
Organism	Homo sapiens(human)
Definition	Homo sapiens variable charge X-linked 3B (VCX3B), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001001888.4

ORF Insert Sequence:

ATGAGTCCAA AGCCGAGAGC CTCGGGACCT CCGGCCAAGG CCAAGGAGGC AGGAAAGAGG 
AAGTCCTCCT CTCAGCCGAG CCCCAGTGAC CCGAAGAAGA AGACTACCAA GGTGGCCAAG 
AAGGGAAAAG CAGTTCGTAG AGGGAGACGC GGGAAGAAAG GGGCTGCGAC AAAGATGGCG 
GCCGTGACGG CACCTGAGGC GGAGAGCGGG CCAGCGGCAC CCGGCCCCAG CGACCAGCCC 
AGCCAGGAGC TCCCTCAGCA CGAGCTGCCG CCGGAGGAGC CAGTGAGCGA GGGGACCCAG 
CACGACCCCC TGAGTCAGGA GAGCGAGCTG GAGGAACCAC TGAGTCAGGA GAGCGAGGTG 
GAAGAACCAC TGAGTCAGGA GAGCCAGGTG GAGGAACCAC TGAGTCAGGA GAGCGAGGTG 
GAAGAACCAC TGAGTCAGGA GAGCCAGGTG GAGGAACCAC TGAGTCAGGA GAGCGAGGTG 
GAGGAACCAC TGAGTCAGGA GAGCGAGGTG GAAGAACCAC TGAGTCAGGA GAGCCAGGTG 
GAGGAACCAC TGAGTCAGGA GAGCGAGGTG GAAGAACCAC TGAGTCAGGA GAGCCAGGTG 
GAGGAACCAC TGAGTCAGGA GAGCGAGATG GAAGAACCAC TGAGTCAGGA GAGCCAGGTG 
GAGGAACCAC TGAGTCAGGA GAGCGAGATG GAAGAACCAC TGAGTCAGGA GAGCGAGATG 
GAAGAACTAC CGAGTGTGTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB.
Human molecular genetics18(23)4650-61(2009 Dec)
Need AC,Attix DK,McEvoy JM,Cirulli ET,Linney KL,Hunt P,Ge D,Heinzen EL,Maia JM,Shianna KV,Weale ME,Cherkas LF,Clement G,Spector TD,Gibson G,Goldstein DB

Modulation of neuritogenesis by a protein implicated in X-linked mental retardation.
The Journal of neuroscience : the official journal of the Society for Neuroscience29(40)12419-27(2009 Oct)
Jiao X,Chen H,Chen J,Herrup K,Firestein BL,Kiledjian M

Analysis of the VCX3A, VCX2 and VCX3B genes shows that VCX3A gene deletion is not sufficient to result in mental retardation in X-linked ichthyosis.
The British journal of dermatology158(3)483-6(2008 Mar)
Cuevas-Covarrubias SA,Gonz?lez-Huerta LM

A shared promoter region suggests a common ancestor for the human VCX/Y, SPANX, and CSAG gene families and the murine CYPT family.
Molecular reproduction and development75(2)219-29(2008 Feb)
Hansen MA,Nielsen JE,Retelska D,Larsen N,Leffers H

Molecular cytogenetic analysis of a familial interstitial deletion Xp22.2-22.3 with a highly variable phenotype in female carriers.
American journal of medical genetics. Part A140(6)604-10(2006 Mar)
Chocholska S,Rossier E,Barbi G,Kehrer-Sawatzki H

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VCX3B cDNA ORF clone, Homo sapiens(human)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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