MEP1B cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	MEP1B
Entrez Gene ID	4225
Full Name	meprin A subunit beta
General protein information	Preferred Names meprin A subunit beta Names meprin A subunit beta N-benzoyl-L-tyrosyl-P-amino-benzoic acid hydrolase subunit beta N-benzoyl-L-tyrosyl-p-amino-benzoic acid hydrolase beta subunit PABA peptide hydrolase PPH beta endopeptidase-2 meprin A, beta meprin B
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 18 Map Location: 18q12.1
Summary	Meprins are multidomain zinc metalloproteases that are highly expressed in mammalian kidney and intestinal brush border membranes, and in leukocytes and certain cancer cells. They are involved in the hydrolysis of a variety of peptide and protein substrates, and have been implicated in cancer and intestinal inflammation. Mature meprins are oligomers of evolutionarily related, but separately encoded alpha and/or beta subunits. Homooligomers of alpha subunit are secreted, whereas, oligomers containing the beta subunit are plasma membrane-bound. This gene encodes the beta subunit. Targeted disruption of this gene in mice affects embryonic viability, renal gene expression profiles, and distribution of the membrane-associated alpha subunit in kidney and intestine. [provided by RefSeq, Oct 2011].
Disorder MIM:	600389

mRNA and Protein(s)

mRNA	Protein	Name
NM_001308171.2	NP_001295100.1	meprin A subunit beta isoform 2 precursor
NM_005925.3	NP_005916.2	meprin A subunit beta isoform 1 precursor
NM_005925.2	NP_005916.2	meprin A subunit beta isoform 1 precursor
XM_011526014.2	XP_011524316.1	meprin A subunit beta isoform X2
NM_001308171.1	NP_001295100.1	meprin A subunit beta isoform 2 precursor
XM_011526013.2	XP_011524315.1	meprin A subunit beta isoform X1

Pathways from BioSystems

Homologies

Bos taurus (cattle)	MEP1B	NP_001137570.1
Gallus gallus (chicken)	MEP1B	XP_419181.3
Danio rerio (zebrafish)	si:ch73-40a17.3	XP_003197854.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP012881	XP_306106.4
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP010764	XP_318543.4
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP011475	XP_317825.4
Homo sapiens (human)	MEP1B	NP_005916.2
	MEP1B	XP_001100668.1
Mus musculus (house mouse)	Mep1b	NP_032612.2
Drosophila melanogaster (fruit fly)	CG6696	NP_573318.1
Xenopus tropicalis (tropical clawed frog)	mep1b	NP_001096352.1
Canis lupus familiaris (dog)	MEP1B	XP_005623043.1
Rattus norvegicus (Norway rat)	Mep1b	NP_037315.1
Pan troglodytes (chimpanzee)	MEP1B	XP_523904.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP010758	XP_318553.4

Gene Ontology
Bibliography

Related articles in PubMed

Mucus Detachment by Host Metalloprotease Meprin ? Requires Shedding of Its Inactive Pro-form, which Is Abrogated by the Pathogenic Protease RgpB.
Wichert R, Ermund A, Schmidt S, Schweinlin M, Ksiazek M, Arnold P, Knittler K, Wilkens F, Potempa B, Rabe B, Stirnberg M, Lucius R, Bartsch JW, Nikolaus S, Falk-Paulsen M, Rosenstiel P, Metzger M, Rose-John S, Potempa J, Hansson GC, Dempsey PJ, Becker-Pauly C
Cell reports21(8)2090-2103(2017 Nov)

Meprin metalloproteases: Molecular regulation and function in inflammation and fibrosis.
Arnold P, Otte A, Becker-Pauly C
Biochimica et biophysica acta1864(11 Pt B)2096-2104(2017 11)

Meprin ? and BMP-1 are differentially regulated by CaCl
Schneppenheim J, Scharfenberg F, Lucius R, Becker-Pauly C, Arnold P
Cell calcium658-13(2017 Jul)

Meprin ? contributes to collagen deposition in lung fibrosis.
Biasin V, Wygrecka M, Marsh LM, Becker-Pauly C, Brcic L, Ghanim B, Klepetko W, Olschewski A, Kwapiszewska G
Scientific reports739969(2017 Jan)

Tetraspanin 8 is an interactor of the metalloprotease meprin ? within tetraspanin-enriched microdomains.
Schmidt F, M?ller M, Prox J, Arnold P, Sch?nherr C, Tredup C, Minder P, Ebsen H, Janssen O, Annaert W, Pietrzik C, Schmidt-Arras D, Sterchi EE, Becker-Pauly C
Biological chemistry397(9)857-69(2016 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

TSPAN8 might be important for the orchestration of meprin beta at the cell surface with impact on certain proteolytic processes
Title: Tetraspanin 8 is an interactor of the metalloprotease meprin ? within tetraspanin-enriched microdomains.

Meprin Beta was found to be activated at the cell surface by matriptase-2.
Title: Metalloprotease meprin ? is activated by transmembrane serine protease matriptase-2 at the cell surface thereby enhancing APP shedding.

n conclusion, we show that the concept of cleavable linkers specific for meprin beta is feasible, as the peptides are rapidly cleaved by the enzyme while retaining their biological properties
Title: Evaluation of ???in-labelled exendin-4 derivatives containing different meprin ?-specific cleavable linkers.

Suggest role for in meprin-beta-Fra2 axis in mediating vascular remodelling in pulmonary hypertension.
Title: Meprin ?, a novel mediator of vascular remodelling underlying pulmonary hypertension.

Meprin metalloproteases A and B inactivate interleukin 6
Title: Meprin metalloproteases inactivate interleukin 6.

The following MEP1B gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MEP1B cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu25358	NM_005925.3 Latest version!	Homo sapiens meprin A subunit beta (MEP1B), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu58944	XM_011526013.2 Latest version!	Homo sapiens meprin A subunit beta (MEP1B), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00
OHu58945	XM_011526014.2 Latest version!	Homo sapiens meprin A subunit beta (MEP1B), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00
OHu51211	NM_001308171.2 Latest version!	Homo sapiens meprin A subunit beta (MEP1B), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$391.30 $559.00
View Old Accession Versions >>
OHu25358	NM_005925.2	Homo sapiens meprin A subunit beta (MEP1B), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu51211	NM_001308171.1	Homo sapiens meprin A subunit beta (MEP1B), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$391.30 $559.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

MEP1B ( NM_005925.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_005916.2 Homo sapiens meprin A subunit beta (MEP1B), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu25358
Clone ID Related Accession (Same CDS sequence)	NM_005925.3 , NM_005925.2
Accession Version	NM_005925.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2106bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-25
Organism	Homo sapiens(human)
Product	meprin A subunit beta isoform 1 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AY695931.1 and X81333.1. On May 17, 2019 this sequence version replaced NM_005925.2. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY695931.1, BC144244.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2144835 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000269202.11/ ENSP00000269202.6 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGATTTAT GGAATCTGTC TTGGTTTCTG TTCTTGGATG CTCTTCTCGT GATTTCTGGC 
TTGGCAACTC CAGAAAACTT TGATGTAGAT GGCGGAATGG ACCAGGACAT ATTTGATATC 
AATGAAGGTT TGGGACTGGA TCTTTTTGAG GGTGACATCA GACTTGATAG GGCACAAATT 
AGAAATTCCA TCATTGGAGA AAAGTATAGA TGGCCTCATA CCATTCCATA TGTTCTAGAA 
GATAGCTTGG AAATGAATGC TAAGGGAGTT ATCCTCAATG CATTTGAACG TTATCGCCTT 
AAAACATGTA TTGACTTTAA GCCTTGGGCT GGAGAAACAA ACTATATATC AGTGTTCAAG 
GGCAGTGGCT GCTGGTCTTC AGTAGGAAAT AGGCGGGTTG GGAAGCAAGA ACTTTCCATC 
GGGGCAAACT GTGACCGAAT AGCAACAGTT CAACACGAGT TCCTCCACGC TCTGGGATTC 
TGGCATGAGC AGTCGCGTTC TGACCGGGAT GACTATGTCA GGATAATGTG GGACAGAATT 
CTGTCAGGCA GAGAGCACAA TTTTAACACC TATAGTGACG ATATATCAGA TTCCCTGAAT 
GTTCCCTATG ATTACACTTC AGTAATGCAC TACAGTAAAA CTGCATTCCA AAATGGAACA 
GAGCCGACAA TTGTCACAAG AATCTCAGAC TTTGAGGATG TGATCGGCCA ACGAATGGAT 
TTCAGTGACT CTGATCTCCT AAAGTTGAAT CAACTGTATA ACTGCTCCTC TTCCTTGAGT 
TTTATGGACT CGTGCAGTTT TGAACTGGAA AATGTGTGTG GCATGATCCA AAGTTCAGGA 
GATAATGCTG ACTGGCAACG GGTTTCACAG GTTCCCAGGG GGCCAGAGAG TGATCACTCC 
AACATGGGCC AGTGCCAAGG TTCTGGTTTC TTCATGCATT TCGATAGCAG CTCTGTAAAT 
GTGGGGGCCA CAGCAGTGCT GGAAAGTAGA ACGCTGTACC CTAAAAGAGG ATTTCAGTGC 
CTGCAATTTT ACTTATATAA CAGTGGCAGT GAAAGTGATC AACTGAACAT CTATATCAGG 
GAGTATTCTG CAGACAATGT GGATGGCAAT TTAACCCTTG TGGAAGAAAT AAAAGAAATA 
CCCACTGGGA GCTGGCAACT TTATCATGTA ACATTGAAAG TGACCAAGAA GTTTAGAGTG 
GTGTTTGAAG GACGCAAAGG CTCTGGTGCA TCACTGGGTG GTCTGTCTAT TGATGACATC 
AATCTTTCGG AAACACGGTG CCCTCATCAT ATCTGGCATA TAAGGAATTT CACACAGTTC 
ATTGGCAGCC CAAATGGAAC TCTGTATAGC CCTCCATTTT ACTCTTCTAA AGGTTATGCC 
TTTCAGATTT ACTTAAATCT AGCCCATGTG ACTAATGCAG GGATATATTT CCACTTGATC 
TCTGGAGCCA ATGATGATCA ATTACAGTGG CCATGTCCTT GGCAACAAGC CACAATGACA 
CTTTTGGATC AAAATCCTGA CATTCGACAG CGTATGTCCA ATCAGCGGAG TATAACTACA 
GACCCATTTA TGACCACCGA TAATGGAAAC TATTTCTGGG ACAGGCCTTC TAAAGTGGGA 
ACAGTGGCTT TGTTCTCTAA TGGAACTCAG TTTAGAAGAG GTGGGGGCTA TGGAACCAGT 
GCCTTTATAA CCCACGAAAG GCTGAAAAGC AGAGATTTTA TAAAAGGAGA TGATGTTTAT 
ATCCTACTGA CAGTGGAAGA CATATCTCAC CTCAACTCTA CACAAATCCA GCTAACACCA 
GCCCCTAGTG TTCAAGACCT CTGCTCAAAA ACCACCTGTA AAAATGACGG TGTCTGCACT 
GTTCGAGATG GCAAAGCTGA GTGCAGGTGC CAGTCAGGGG AAGACTGGTG GTACATGGGA 
GAAAGGTGTG AAAAGAGAGG CTCCACCCGA GACACCATAG TCATTGCTGT TTCATCTACT 
GTTGCTGTGT TTGCCTTGAT GCTGATCATC ACCCTTGTCA GTGTCTATTG CACCAGGAAG 
AAATATCGTG AAAGGATGAG CTCAAATCGA CCAAATTTGA CTCCGCAAAA TCAGCATGCT 
TTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005916.2
CDS	33..2138
Translation	MDLWNLSWFLFLDALLVISGLATPENFDVDGGMDQDIFDINEGLGLDLFEGDIRLDRAQIRNSIIGEKYRWPHTIPYVLEDSLEMNAKGVILNAFERYRLKTCIDFKPWAGETNYISVFKGSGCWSSVGNRRVGKQELSIGANCDRIATVQHEFLHALGFWHEQSRSDRDDYVRIMWDRILSGREHNFNTYSDDISDSLNVPYDYTSVMHYSKTAFQNGTEPTIVTRISDFEDVIGQRMDFSDSDLLKLNQLYNCSSSLSFMDSCSFELENVCGMIQSSGDNADWQRVSQVPRGPESDHSNMGQCQGSGFFMHFDSSSVNVGATAVLESRTLYPKRGFQCLQFYLYNSGSESDQLNIYIREYSADNVDGNLTLVEEIKEIPTGSWQLYHVTLKVTKKFRVVFEGRKGSGASLGGLSIDDINLSETRCPHHIWHIRNFTQFIGSPNGTLYSPPFYSSKGYAFQIYLNLAHVTNAGIYFHLISGANDDQLQWPCPWQQATMTLLDQNPDIRQRMSNQRSITTDPFMTTDNGNYFWDRPSKVGTVALFSNGTQFRRGGGYGTSAFITHERLKSRDFIKGDDVYILLTVEDISHLNSTQIQLTPAPSVQDLCSKTTCKNDGVCTVRDGKAECRCQSGEDWWYMGERCEKRGSTRDTIVIAVSSTVAVFALMLIITLVSVYCTRKKYRERMSSNRPNLTPQNQHAF

Target ORF information:

RefSeq Version	NM_005925.3
Organism	Homo sapiens(human)
Definition	Homo sapiens meprin A subunit beta (MEP1B), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005925.3

ORF Insert Sequence:

ATGGATTTAT GGAATCTGTC TTGGTTTCTG TTCTTGGATG CTCTTCTCGT GATTTCTGGC 
TTGGCAACTC CAGAAAACTT TGATGTAGAT GGCGGAATGG ACCAGGACAT ATTTGATATC 
AATGAAGGTT TGGGACTGGA TCTTTTTGAG GGTGACATCA GACTTGATAG GGCACAAATT 
AGAAATTCCA TCATTGGAGA AAAGTATAGA TGGCCTCATA CCATTCCATA TGTTCTAGAA 
GATAGCTTGG AAATGAATGC TAAGGGAGTT ATCCTCAATG CATTTGAACG TTATCGCCTT 
AAAACATGTA TTGACTTTAA GCCTTGGGCT GGAGAAACAA ACTATATATC AGTGTTCAAG 
GGCAGTGGCT GCTGGTCTTC AGTAGGAAAT AGGCGGGTTG GGAAGCAAGA ACTTTCCATC 
GGGGCAAACT GTGACCGAAT AGCAACAGTT CAACACGAGT TCCTCCACGC TCTGGGATTC 
TGGCATGAGC AGTCGCGTTC TGACCGGGAT GACTATGTCA GGATAATGTG GGACAGAATT 
CTGTCAGGCA GAGAGCACAA TTTTAACACC TATAGTGACG ATATATCAGA TTCCCTGAAT 
GTTCCCTATG ATTACACTTC AGTAATGCAC TACAGTAAAA CTGCATTCCA AAATGGAACA 
GAGCCGACAA TTGTCACAAG AATCTCAGAC TTTGAGGATG TGATCGGCCA ACGAATGGAT 
TTCAGTGACT CTGATCTCCT AAAGTTGAAT CAACTGTATA ACTGCTCCTC TTCCTTGAGT 
TTTATGGACT CGTGCAGTTT TGAACTGGAA AATGTGTGTG GCATGATCCA AAGTTCAGGA 
GATAATGCTG ACTGGCAACG GGTTTCACAG GTTCCCAGGG GGCCAGAGAG TGATCACTCC 
AACATGGGCC AGTGCCAAGG TTCTGGTTTC TTCATGCATT TCGATAGCAG CTCTGTAAAT 
GTGGGGGCCA CAGCAGTGCT GGAAAGTAGA ACGCTGTACC CTAAAAGAGG ATTTCAGTGC 
CTGCAATTTT ACTTATATAA CAGTGGCAGT GAAAGTGATC AACTGAACAT CTATATCAGG 
GAGTATTCTG CAGACAATGT GGATGGCAAT TTAACCCTTG TGGAAGAAAT AAAAGAAATA 
CCCACTGGGA GCTGGCAACT TTATCATGTA ACATTGAAAG TGACCAAGAA GTTTAGAGTG 
GTGTTTGAAG GACGCAAAGG CTCTGGTGCA TCACTGGGTG GTCTGTCTAT TGATGACATC 
AATCTTTCGG AAACACGGTG CCCTCATCAT ATCTGGCATA TAAGGAATTT CACACAGTTC 
ATTGGCAGCC CAAATGGAAC TCTGTATAGC CCTCCATTTT ACTCTTCTAA AGGTTATGCC 
TTTCAGATTT ACTTAAATCT AGCCCATGTG ACTAATGCAG GGATATATTT CCACTTGATC 
TCTGGAGCCA ATGATGATCA ATTACAGTGG CCATGTCCTT GGCAACAAGC CACAATGACA 
CTTTTGGATC AAAATCCTGA CATTCGACAG CGTATGTCCA ATCAGCGGAG TATAACTACA 
GACCCATTTA TGACCACCGA TAATGGAAAC TATTTCTGGG ACAGGCCTTC TAAAGTGGGA 
ACAGTGGCTT TGTTCTCTAA TGGAACTCAG TTTAGAAGAG GTGGGGGCTA TGGAACCAGT 
GCCTTTATAA CCCACGAAAG GCTGAAAAGC AGAGATTTTA TAAAAGGAGA TGATGTTTAT 
ATCCTACTGA CAGTGGAAGA CATATCTCAC CTCAACTCTA CACAAATCCA GCTAACACCA 
GCCCCTAGTG TTCAAGACCT CTGCTCAAAA ACCACCTGTA AAAATGACGG TGTCTGCACT 
GTTCGAGATG GCAAAGCTGA GTGCAGGTGC CAGTCAGGGG AAGACTGGTG GTACATGGGA 
GAAAGGTGTG AAAAGAGAGG CTCCACCCGA GACACCATAG TCATTGCTGT TTCATCTACT 
GTTGCTGTGT TTGCCTTGAT GCTGATCATC ACCCTTGTCA GTGTCTATTG CACCAGGAAG 
AAATATCGTG AAAGGATGAG CTCAAATCGA CCAAATTTGA CTCCGCAAAA TCAGCATGCT 
TTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MEP1B ( NM_005925.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_005916.2 Homo sapiens meprin A subunit beta (MEP1B), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu25358
Clone ID Related Accession (Same CDS sequence)	NM_005925.3 , NM_005925.2
Accession Version	NM_005925.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2106bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-19
Organism	Homo sapiens(human)
Product	meprin A subunit beta isoform 1 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AY695931.1 and X81333.1. On Jul 24, 2007 this sequence version replaced NM_005925.1. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY695931.1, BC136559.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2144835 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGATTTAT GGAATCTGTC TTGGTTTCTG TTCTTGGATG CTCTTCTCGT GATTTCTGGC 
TTGGCAACTC CAGAAAACTT TGATGTAGAT GGCGGAATGG ACCAGGACAT ATTTGATATC 
AATGAAGGTT TGGGACTGGA TCTTTTTGAG GGTGACATCA GACTTGATAG GGCACAAATT 
AGAAATTCCA TCATTGGAGA AAAGTATAGA TGGCCTCATA CCATTCCATA TGTTCTAGAA 
GATAGCTTGG AAATGAATGC TAAGGGAGTT ATCCTCAATG CATTTGAACG TTATCGCCTT 
AAAACATGTA TTGACTTTAA GCCTTGGGCT GGAGAAACAA ACTATATATC AGTGTTCAAG 
GGCAGTGGCT GCTGGTCTTC AGTAGGAAAT AGGCGGGTTG GGAAGCAAGA ACTTTCCATC 
GGGGCAAACT GTGACCGAAT AGCAACAGTT CAACACGAGT TCCTCCACGC TCTGGGATTC 
TGGCATGAGC AGTCGCGTTC TGACCGGGAT GACTATGTCA GGATAATGTG GGACAGAATT 
CTGTCAGGCA GAGAGCACAA TTTTAACACC TATAGTGACG ATATATCAGA TTCCCTGAAT 
GTTCCCTATG ATTACACTTC AGTAATGCAC TACAGTAAAA CTGCATTCCA AAATGGAACA 
GAGCCGACAA TTGTCACAAG AATCTCAGAC TTTGAGGATG TGATCGGCCA ACGAATGGAT 
TTCAGTGACT CTGATCTCCT AAAGTTGAAT CAACTGTATA ACTGCTCCTC TTCCTTGAGT 
TTTATGGACT CGTGCAGTTT TGAACTGGAA AATGTGTGTG GCATGATCCA AAGTTCAGGA 
GATAATGCTG ACTGGCAACG GGTTTCACAG GTTCCCAGGG GGCCAGAGAG TGATCACTCC 
AACATGGGCC AGTGCCAAGG TTCTGGTTTC TTCATGCATT TCGATAGCAG CTCTGTAAAT 
GTGGGGGCCA CAGCAGTGCT GGAAAGTAGA ACGCTGTACC CTAAAAGAGG ATTTCAGTGC 
CTGCAATTTT ACTTATATAA CAGTGGCAGT GAAAGTGATC AACTGAACAT CTATATCAGG 
GAGTATTCTG CAGACAATGT GGATGGCAAT TTAACCCTTG TGGAAGAAAT AAAAGAAATA 
CCCACTGGGA GCTGGCAACT TTATCATGTA ACATTGAAAG TGACCAAGAA GTTTAGAGTG 
GTGTTTGAAG GACGCAAAGG CTCTGGTGCA TCACTGGGTG GTCTGTCTAT TGATGACATC 
AATCTTTCGG AAACACGGTG CCCTCATCAT ATCTGGCATA TAAGGAATTT CACACAGTTC 
ATTGGCAGCC CAAATGGAAC TCTGTATAGC CCTCCATTTT ACTCTTCTAA AGGTTATGCC 
TTTCAGATTT ACTTAAATCT AGCCCATGTG ACTAATGCAG GGATATATTT CCACTTGATC 
TCTGGAGCCA ATGATGATCA ATTACAGTGG CCATGTCCTT GGCAACAAGC CACAATGACA 
CTTTTGGATC AAAATCCTGA CATTCGACAG CGTATGTCCA ATCAGCGGAG TATAACTACA 
GACCCATTTA TGACCACCGA TAATGGAAAC TATTTCTGGG ACAGGCCTTC TAAAGTGGGA 
ACAGTGGCTT TGTTCTCTAA TGGAACTCAG TTTAGAAGAG GTGGGGGCTA TGGAACCAGT 
GCCTTTATAA CCCACGAAAG GCTGAAAAGC AGAGATTTTA TAAAAGGAGA TGATGTTTAT 
ATCCTACTGA CAGTGGAAGA CATATCTCAC CTCAACTCTA CACAAATCCA GCTAACACCA 
GCCCCTAGTG TTCAAGACCT CTGCTCAAAA ACCACCTGTA AAAATGACGG TGTCTGCACT 
GTTCGAGATG GCAAAGCTGA GTGCAGGTGC CAGTCAGGGG AAGACTGGTG GTACATGGGA 
GAAAGGTGTG AAAAGAGAGG CTCCACCCGA GACACCATAG TCATTGCTGT TTCATCTACT 
GTTGCTGTGT TTGCCTTGAT GCTGATCATC ACCCTTGTCA GTGTCTATTG CACCAGGAAG 
AAATATCGTG AAAGGATGAG CTCAAATCGA CCAAATTTGA CTCCGCAAAA TCAGCATGCT 
TTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005916.2
CDS	48..2153
Translation	MDLWNLSWFLFLDALLVISGLATPENFDVDGGMDQDIFDINEGLGLDLFEGDIRLDRAQIRNSIIGEKYRWPHTIPYVLEDSLEMNAKGVILNAFERYRLKTCIDFKPWAGETNYISVFKGSGCWSSVGNRRVGKQELSIGANCDRIATVQHEFLHALGFWHEQSRSDRDDYVRIMWDRILSGREHNFNTYSDDISDSLNVPYDYTSVMHYSKTAFQNGTEPTIVTRISDFEDVIGQRMDFSDSDLLKLNQLYNCSSSLSFMDSCSFELENVCGMIQSSGDNADWQRVSQVPRGPESDHSNMGQCQGSGFFMHFDSSSVNVGATAVLESRTLYPKRGFQCLQFYLYNSGSESDQLNIYIREYSADNVDGNLTLVEEIKEIPTGSWQLYHVTLKVTKKFRVVFEGRKGSGASLGGLSIDDINLSETRCPHHIWHIRNFTQFIGSPNGTLYSPPFYSSKGYAFQIYLNLAHVTNAGIYFHLISGANDDQLQWPCPWQQATMTLLDQNPDIRQRMSNQRSITTDPFMTTDNGNYFWDRPSKVGTVALFSNGTQFRRGGGYGTSAFITHERLKSRDFIKGDDVYILLTVEDISHLNSTQIQLTPAPSVQDLCSKTTCKNDGVCTVRDGKAECRCQSGEDWWYMGERCEKRGSTRDTIVIAVSSTVAVFALMLIITLVSVYCTRKKYRERMSSNRPNLTPQNQHAF

Target ORF information:

RefSeq Version	NM_005925.2
Organism	Homo sapiens(human)
Definition	Homo sapiens meprin A subunit beta (MEP1B), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005925.2

ORF Insert Sequence:

ATGGATTTAT GGAATCTGTC TTGGTTTCTG TTCTTGGATG CTCTTCTCGT GATTTCTGGC 
TTGGCAACTC CAGAAAACTT TGATGTAGAT GGCGGAATGG ACCAGGACAT ATTTGATATC 
AATGAAGGTT TGGGACTGGA TCTTTTTGAG GGTGACATCA GACTTGATAG GGCACAAATT 
AGAAATTCCA TCATTGGAGA AAAGTATAGA TGGCCTCATA CCATTCCATA TGTTCTAGAA 
GATAGCTTGG AAATGAATGC TAAGGGAGTT ATCCTCAATG CATTTGAACG TTATCGCCTT 
AAAACATGTA TTGACTTTAA GCCTTGGGCT GGAGAAACAA ACTATATATC AGTGTTCAAG 
GGCAGTGGCT GCTGGTCTTC AGTAGGAAAT AGGCGGGTTG GGAAGCAAGA ACTTTCCATC 
GGGGCAAACT GTGACCGAAT AGCAACAGTT CAACACGAGT TCCTCCACGC TCTGGGATTC 
TGGCATGAGC AGTCGCGTTC TGACCGGGAT GACTATGTCA GGATAATGTG GGACAGAATT 
CTGTCAGGCA GAGAGCACAA TTTTAACACC TATAGTGACG ATATATCAGA TTCCCTGAAT 
GTTCCCTATG ATTACACTTC AGTAATGCAC TACAGTAAAA CTGCATTCCA AAATGGAACA 
GAGCCGACAA TTGTCACAAG AATCTCAGAC TTTGAGGATG TGATCGGCCA ACGAATGGAT 
TTCAGTGACT CTGATCTCCT AAAGTTGAAT CAACTGTATA ACTGCTCCTC TTCCTTGAGT 
TTTATGGACT CGTGCAGTTT TGAACTGGAA AATGTGTGTG GCATGATCCA AAGTTCAGGA 
GATAATGCTG ACTGGCAACG GGTTTCACAG GTTCCCAGGG GGCCAGAGAG TGATCACTCC 
AACATGGGCC AGTGCCAAGG TTCTGGTTTC TTCATGCATT TCGATAGCAG CTCTGTAAAT 
GTGGGGGCCA CAGCAGTGCT GGAAAGTAGA ACGCTGTACC CTAAAAGAGG ATTTCAGTGC 
CTGCAATTTT ACTTATATAA CAGTGGCAGT GAAAGTGATC AACTGAACAT CTATATCAGG 
GAGTATTCTG CAGACAATGT GGATGGCAAT TTAACCCTTG TGGAAGAAAT AAAAGAAATA 
CCCACTGGGA GCTGGCAACT TTATCATGTA ACATTGAAAG TGACCAAGAA GTTTAGAGTG 
GTGTTTGAAG GACGCAAAGG CTCTGGTGCA TCACTGGGTG GTCTGTCTAT TGATGACATC 
AATCTTTCGG AAACACGGTG CCCTCATCAT ATCTGGCATA TAAGGAATTT CACACAGTTC 
ATTGGCAGCC CAAATGGAAC TCTGTATAGC CCTCCATTTT ACTCTTCTAA AGGTTATGCC 
TTTCAGATTT ACTTAAATCT AGCCCATGTG ACTAATGCAG GGATATATTT CCACTTGATC 
TCTGGAGCCA ATGATGATCA ATTACAGTGG CCATGTCCTT GGCAACAAGC CACAATGACA 
CTTTTGGATC AAAATCCTGA CATTCGACAG CGTATGTCCA ATCAGCGGAG TATAACTACA 
GACCCATTTA TGACCACCGA TAATGGAAAC TATTTCTGGG ACAGGCCTTC TAAAGTGGGA 
ACAGTGGCTT TGTTCTCTAA TGGAACTCAG TTTAGAAGAG GTGGGGGCTA TGGAACCAGT 
GCCTTTATAA CCCACGAAAG GCTGAAAAGC AGAGATTTTA TAAAAGGAGA TGATGTTTAT 
ATCCTACTGA CAGTGGAAGA CATATCTCAC CTCAACTCTA CACAAATCCA GCTAACACCA 
GCCCCTAGTG TTCAAGACCT CTGCTCAAAA ACCACCTGTA AAAATGACGG TGTCTGCACT 
GTTCGAGATG GCAAAGCTGA GTGCAGGTGC CAGTCAGGGG AAGACTGGTG GTACATGGGA 
GAAAGGTGTG AAAAGAGAGG CTCCACCCGA GACACCATAG TCATTGCTGT TTCATCTACT 
GTTGCTGTGT TTGCCTTGAT GCTGATCATC ACCCTTGTCA GTGTCTATTG CACCAGGAAG 
AAATATCGTG AAAGGATGAG CTCAAATCGA CCAAATTTGA CTCCGCAAAA TCAGCATGCT 
TTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MEP1B ( XM_011526013.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011524315.1 Homo sapiens meprin A subunit beta (MEP1B), transcript variant X1, mRNA.

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CloneID	OHu58944
Clone ID Related Accession (Same CDS sequence)	XM_011526013.2
Accession Version	XM_011526013.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1887bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	meprin A subunit beta isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000018.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011526013.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGATTTAT GGAATCTGTC TTGGTTTCTG TTCTTGGATG CTCTTCTCGT GATTTCTGGC 
TTGGCAACTC CAGAAAACTT TGATGTAGAT GGCGGAATGG ACCAGGACAT ATTTGATATC 
AATGAAGGTT TGGGACTGGA TCTTTTTGAG GGTGACATCA GACTTGATAG GGCACAAATT 
AGAAATTCCA TCATTGGAGA AAAGTATAGA TGGCCTCATA CCATTCCATA TGTTCTAGAA 
GATAGCTTGG AAATGAATGC TAAGGGAGTT ATCCTCAATG CATTTGAACG TTATCGCCTT 
AAAACATGTA TTGACTTTAA GCCTTGGGCT GGAGAAACAA ACTATATATC AGTGTTCAAG 
GGCAGTGGCT GCTGGTCTTC AGTAGGAAAT AGGCGGGTTG GGAAGCAAGA ACTTTCCATC 
GGGGCAAACT GTGACCGAAT AGCAACAGTT CAACACGAGT TCCTCCACGC TCTGGGATTC 
TGGCATGAGC AGTCGCGTTC TGACCGGGAT GACTATGTCA GGATAATGTG GGACAGAATT 
CTGTCAGCCT CTTCCTTGAG TTTTATGGAC TCGTGCAGTT TTGAACTGGA AAATGTGTGT 
GGCATGATCC AAAGTTCAGG AGATAATGCT GACTGGCAAC GGGTTTCACA GGTTCCCAGG 
GGGCCAGAGA GTGATCACTC CAACATGGGC CAGTGCCAAG GTTCTGGTTT CTTCATGCAT 
TTCGATAGCA GCTCTGTAAA TGTGGGGGCC ACAGCAGTGC TGGAAAGTAG AACGCTGTAC 
CCTAAAAGAG GATTTCAGTG CCTGCAATTT TACTTATATA ACAGTGGCAG TGAAAGTGAT 
CAACTGAACA TCTATATCAG GGAGTATTCT GCAGACAATG TGGATGGCAA TTTAACCCTT 
GTGGAAGAAA TAAAAGAAAT ACCCACTGGG AGCTGGCAAC TTTATCATGT AACATTGAAA 
GTGACCAAGA AGTTTAGAGT GGTGTTTGAA GGACGCAAAG GCTCTGGTGC ATCACTGGGT 
GGTCTGTCTA TTGATGACAT CAATCTTTCG GAAACACGGT GCCCTCATCA TATCTGGCAT 
ATAAGGAATT TCACACAGTT CATTGGCAGC CCAAATGGAA CTCTGTATAG CCCTCCATTT 
TACTCTTCTA AAGGTTATGC CTTTCAGATT TACTTAAATC TAGCCCATGT GACTAATGCA 
GGGATATATT TCCACTTGAT CTCTGGAGCC AATGATGATC AATTACAGTG GCCATGTCCT 
TGGCAACAAG CCACAATGAC ACTTTTGGAT CAAAATCCTG ACATTCGACA GCGTATGTCC 
AATCAGCGGA GTATAACTAC AGACCCATTT ATGACCACCG ATAATGGAAA CTATTTCTGG 
GACAGGCCTT CTAAAGTGGG AACAGTGGCT TTGTTCTCTA ATGGAACTCA GTTTAGAAGA 
GGTGGGGGCT ATGGAACCAG TGCCTTTATA ACCCACGAAA GGCTGAAAAG CAGAGATTTT 
ATAAAAGGAG ATGATGTTTA TATCCTACTG ACAGTGGAAG ACATATCTCA CCTCAACTCT 
ACACAAATCC AGCTAACACC AGCCCCTAGT GTTCAAGACC TCTGCTCAAA AACCACCTGT 
AAAAATGACG GTGTCTGCAC TGTTCGAGAT GGCAAAGCTG AGTGCAGGTG CCAGTCAGGG 
GAAGACTGGT GGTACATGGG AGAAAGGTGT GAAAAGAGAG GCTCCACCCG AGACACCATA 
GTCATTGCTG TTTCATCTAC TGTTGCTGTG TTTGCCTTGA TGCTGATCAT CACCCTTGTC 
AGTGTCTATT GCACCAGGAA GAAATATCGT GAAAGGATGA GCTCAAATCG ACCAAATTTG 
ACTCCGCAAA ATCAGCATGC TTTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011524315.1
CDS	33..1919
Translation	MDLWNLSWFLFLDALLVISGLATPENFDVDGGMDQDIFDINEGLGLDLFEGDIRLDRAQIRNSIIGEKYRWPHTIPYVLEDSLEMNAKGVILNAFERYRLKTCIDFKPWAGETNYISVFKGSGCWSSVGNRRVGKQELSIGANCDRIATVQHEFLHALGFWHEQSRSDRDDYVRIMWDRILSASSLSFMDSCSFELENVCGMIQSSGDNADWQRVSQVPRGPESDHSNMGQCQGSGFFMHFDSSSVNVGATAVLESRTLYPKRGFQCLQFYLYNSGSESDQLNIYIREYSADNVDGNLTLVEEIKEIPTGSWQLYHVTLKVTKKFRVVFEGRKGSGASLGGLSIDDINLSETRCPHHIWHIRNFTQFIGSPNGTLYSPPFYSSKGYAFQIYLNLAHVTNAGIYFHLISGANDDQLQWPCPWQQATMTLLDQNPDIRQRMSNQRSITTDPFMTTDNGNYFWDRPSKVGTVALFSNGTQFRRGGGYGTSAFITHERLKSRDFIKGDDVYILLTVEDISHLNSTQIQLTPAPSVQDLCSKTTCKNDGVCTVRDGKAECRCQSGEDWWYMGERCEKRGSTRDTIVIAVSSTVAVFALMLIITLVSVYCTRKKYRERMSSNRPNLTPQNQHAF

Target ORF information:

RefSeq Version	XM_011526013.2
Organism	Homo sapiens(human)
Definition	Homo sapiens meprin A subunit beta (MEP1B), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011526013.2

ORF Insert Sequence:

ATGGATTTAT GGAATCTGTC TTGGTTTCTG TTCTTGGATG CTCTTCTCGT GATTTCTGGC 
TTGGCAACTC CAGAAAACTT TGATGTAGAT GGCGGAATGG ACCAGGACAT ATTTGATATC 
AATGAAGGTT TGGGACTGGA TCTTTTTGAG GGTGACATCA GACTTGATAG GGCACAAATT 
AGAAATTCCA TCATTGGAGA AAAGTATAGA TGGCCTCATA CCATTCCATA TGTTCTAGAA 
GATAGCTTGG AAATGAATGC TAAGGGAGTT ATCCTCAATG CATTTGAACG TTATCGCCTT 
AAAACATGTA TTGACTTTAA GCCTTGGGCT GGAGAAACAA ACTATATATC AGTGTTCAAG 
GGCAGTGGCT GCTGGTCTTC AGTAGGAAAT AGGCGGGTTG GGAAGCAAGA ACTTTCCATC 
GGGGCAAACT GTGACCGAAT AGCAACAGTT CAACACGAGT TCCTCCACGC TCTGGGATTC 
TGGCATGAGC AGTCGCGTTC TGACCGGGAT GACTATGTCA GGATAATGTG GGACAGAATT 
CTGTCAGCCT CTTCCTTGAG TTTTATGGAC TCGTGCAGTT TTGAACTGGA AAATGTGTGT 
GGCATGATCC AAAGTTCAGG AGATAATGCT GACTGGCAAC GGGTTTCACA GGTTCCCAGG 
GGGCCAGAGA GTGATCACTC CAACATGGGC CAGTGCCAAG GTTCTGGTTT CTTCATGCAT 
TTCGATAGCA GCTCTGTAAA TGTGGGGGCC ACAGCAGTGC TGGAAAGTAG AACGCTGTAC 
CCTAAAAGAG GATTTCAGTG CCTGCAATTT TACTTATATA ACAGTGGCAG TGAAAGTGAT 
CAACTGAACA TCTATATCAG GGAGTATTCT GCAGACAATG TGGATGGCAA TTTAACCCTT 
GTGGAAGAAA TAAAAGAAAT ACCCACTGGG AGCTGGCAAC TTTATCATGT AACATTGAAA 
GTGACCAAGA AGTTTAGAGT GGTGTTTGAA GGACGCAAAG GCTCTGGTGC ATCACTGGGT 
GGTCTGTCTA TTGATGACAT CAATCTTTCG GAAACACGGT GCCCTCATCA TATCTGGCAT 
ATAAGGAATT TCACACAGTT CATTGGCAGC CCAAATGGAA CTCTGTATAG CCCTCCATTT 
TACTCTTCTA AAGGTTATGC CTTTCAGATT TACTTAAATC TAGCCCATGT GACTAATGCA 
GGGATATATT TCCACTTGAT CTCTGGAGCC AATGATGATC AATTACAGTG GCCATGTCCT 
TGGCAACAAG CCACAATGAC ACTTTTGGAT CAAAATCCTG ACATTCGACA GCGTATGTCC 
AATCAGCGGA GTATAACTAC AGACCCATTT ATGACCACCG ATAATGGAAA CTATTTCTGG 
GACAGGCCTT CTAAAGTGGG AACAGTGGCT TTGTTCTCTA ATGGAACTCA GTTTAGAAGA 
GGTGGGGGCT ATGGAACCAG TGCCTTTATA ACCCACGAAA GGCTGAAAAG CAGAGATTTT 
ATAAAAGGAG ATGATGTTTA TATCCTACTG ACAGTGGAAG ACATATCTCA CCTCAACTCT 
ACACAAATCC AGCTAACACC AGCCCCTAGT GTTCAAGACC TCTGCTCAAA AACCACCTGT 
AAAAATGACG GTGTCTGCAC TGTTCGAGAT GGCAAAGCTG AGTGCAGGTG CCAGTCAGGG 
GAAGACTGGT GGTACATGGG AGAAAGGTGT GAAAAGAGAG GCTCCACCCG AGACACCATA 
GTCATTGCTG TTTCATCTAC TGTTGCTGTG TTTGCCTTGA TGCTGATCAT CACCCTTGTC 
AGTGTCTATT GCACCAGGAA GAAATATCGT GAAAGGATGA GCTCAAATCG ACCAAATTTG 
ACTCCGCAAA ATCAGCATGC TTTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MEP1B ( XM_011526014.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011524316.1 Homo sapiens meprin A subunit beta (MEP1B), transcript variant X2, mRNA.

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CloneID	OHu58945
Clone ID Related Accession (Same CDS sequence)	XM_011526014.2
Accession Version	XM_011526014.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1734bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	meprin A subunit beta isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000018.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011526014.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGATTTAT GGAATCTGTC TTGGTTTCTG TTCTTGGATG CTCTTCTCGT GATTTCTGGC 
TTGGCAACTC CAGAAAACTT TGATGTAGAT GGCGGAATGG ACCAGGACAT ATTTGATATC 
AATGAAGGTT TGGGACTGGA TCTTTTTGAG GGTGACATCA GACTTGATAG GGCACAAATT 
AGAAATTCCA TCATTGGAGA AAAGTATAGA TGGCCTCATA CCATTCCATA TGTTCTAGAA 
GATAGCTTGG AAATGAATGC TAAGGGAGTT ATCCTCAATG CATTTGAACG TTATCGCCTT 
AAAACATGTA TTGACTTTAA GCCTTGGGCT GGAGAAACAA ACTATATATC AGTGTTCAAG 
GGCAGTGGCT GCTGGTCTTC AGTAGGAAAT AGGCGGGTTG GGAAGCAAGA ACTTTCCATC 
GGGGCAAACT GTGACCGAAT AGCAACAGTT CAACACGAGT TCCTCCACGC TCTGGGATTC 
TGGCATGAGC AGTCGCGTTC TGACCGGGAT GACTATGTCA GGATAATGTG GGACAGAATT 
CTGTCAGGTT CTGGTTTCTT CATGCATTTC GATAGCAGCT CTGTAAATGT GGGGGCCACA 
GCAGTGCTGG AAAGTAGAAC GCTGTACCCT AAAAGAGGAT TTCAGTGCCT GCAATTTTAC 
TTATATAACA GTGGCAGTGA AAGTGATCAA CTGAACATCT ATATCAGGGA GTATTCTGCA 
GACAATGTGG ATGGCAATTT AACCCTTGTG GAAGAAATAA AAGAAATACC CACTGGGAGC 
TGGCAACTTT ATCATGTAAC ATTGAAAGTG ACCAAGAAGT TTAGAGTGGT GTTTGAAGGA 
CGCAAAGGCT CTGGTGCATC ACTGGGTGGT CTGTCTATTG ATGACATCAA TCTTTCGGAA 
ACACGGTGCC CTCATCATAT CTGGCATATA AGGAATTTCA CACAGTTCAT TGGCAGCCCA 
AATGGAACTC TGTATAGCCC TCCATTTTAC TCTTCTAAAG GTTATGCCTT TCAGATTTAC 
TTAAATCTAG CCCATGTGAC TAATGCAGGG ATATATTTCC ACTTGATCTC TGGAGCCAAT 
GATGATCAAT TACAGTGGCC ATGTCCTTGG CAACAAGCCA CAATGACACT TTTGGATCAA 
AATCCTGACA TTCGACAGCG TATGTCCAAT CAGCGGAGTA TAACTACAGA CCCATTTATG 
ACCACCGATA ATGGAAACTA TTTCTGGGAC AGGCCTTCTA AAGTGGGAAC AGTGGCTTTG 
TTCTCTAATG GAACTCAGTT TAGAAGAGGT GGGGGCTATG GAACCAGTGC CTTTATAACC 
CACGAAAGGC TGAAAAGCAG AGATTTTATA AAAGGAGATG ATGTTTATAT CCTACTGACA 
GTGGAAGACA TATCTCACCT CAACTCTACA CAAATCCAGC TAACACCAGC CCCTAGTGTT 
CAAGACCTCT GCTCAAAAAC CACCTGTAAA AATGACGGTG TCTGCACTGT TCGAGATGGC 
AAAGCTGAGT GCAGGTGCCA GTCAGGGGAA GACTGGTGGT ACATGGGAGA AAGGTGTGAA 
AAGAGAGGCT CCACCCGAGA CACCATAGTC ATTGCTGTTT CATCTACTGT TGCTGTGTTT 
GCCTTGATGC TGATCATCAC CCTTGTCAGT GTCTATTGCA CCAGGAAGAA ATATCGTGAA 
AGGATGAGCT CAAATCGACC AAATTTGACT CCGCAAAATC AGCATGCTTT TTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011524316.1
CDS	33..1766
Translation	MDLWNLSWFLFLDALLVISGLATPENFDVDGGMDQDIFDINEGLGLDLFEGDIRLDRAQIRNSIIGEKYRWPHTIPYVLEDSLEMNAKGVILNAFERYRLKTCIDFKPWAGETNYISVFKGSGCWSSVGNRRVGKQELSIGANCDRIATVQHEFLHALGFWHEQSRSDRDDYVRIMWDRILSGSGFFMHFDSSSVNVGATAVLESRTLYPKRGFQCLQFYLYNSGSESDQLNIYIREYSADNVDGNLTLVEEIKEIPTGSWQLYHVTLKVTKKFRVVFEGRKGSGASLGGLSIDDINLSETRCPHHIWHIRNFTQFIGSPNGTLYSPPFYSSKGYAFQIYLNLAHVTNAGIYFHLISGANDDQLQWPCPWQQATMTLLDQNPDIRQRMSNQRSITTDPFMTTDNGNYFWDRPSKVGTVALFSNGTQFRRGGGYGTSAFITHERLKSRDFIKGDDVYILLTVEDISHLNSTQIQLTPAPSVQDLCSKTTCKNDGVCTVRDGKAECRCQSGEDWWYMGERCEKRGSTRDTIVIAVSSTVAVFALMLIITLVSVYCTRKKYRERMSSNRPNLTPQNQHAF

Target ORF information:

RefSeq Version	XM_011526014.2
Organism	Homo sapiens(human)
Definition	Homo sapiens meprin A subunit beta (MEP1B), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011526014.2

ORF Insert Sequence:

ATGGATTTAT GGAATCTGTC TTGGTTTCTG TTCTTGGATG CTCTTCTCGT GATTTCTGGC 
TTGGCAACTC CAGAAAACTT TGATGTAGAT GGCGGAATGG ACCAGGACAT ATTTGATATC 
AATGAAGGTT TGGGACTGGA TCTTTTTGAG GGTGACATCA GACTTGATAG GGCACAAATT 
AGAAATTCCA TCATTGGAGA AAAGTATAGA TGGCCTCATA CCATTCCATA TGTTCTAGAA 
GATAGCTTGG AAATGAATGC TAAGGGAGTT ATCCTCAATG CATTTGAACG TTATCGCCTT 
AAAACATGTA TTGACTTTAA GCCTTGGGCT GGAGAAACAA ACTATATATC AGTGTTCAAG 
GGCAGTGGCT GCTGGTCTTC AGTAGGAAAT AGGCGGGTTG GGAAGCAAGA ACTTTCCATC 
GGGGCAAACT GTGACCGAAT AGCAACAGTT CAACACGAGT TCCTCCACGC TCTGGGATTC 
TGGCATGAGC AGTCGCGTTC TGACCGGGAT GACTATGTCA GGATAATGTG GGACAGAATT 
CTGTCAGGTT CTGGTTTCTT CATGCATTTC GATAGCAGCT CTGTAAATGT GGGGGCCACA 
GCAGTGCTGG AAAGTAGAAC GCTGTACCCT AAAAGAGGAT TTCAGTGCCT GCAATTTTAC 
TTATATAACA GTGGCAGTGA AAGTGATCAA CTGAACATCT ATATCAGGGA GTATTCTGCA 
GACAATGTGG ATGGCAATTT AACCCTTGTG GAAGAAATAA AAGAAATACC CACTGGGAGC 
TGGCAACTTT ATCATGTAAC ATTGAAAGTG ACCAAGAAGT TTAGAGTGGT GTTTGAAGGA 
CGCAAAGGCT CTGGTGCATC ACTGGGTGGT CTGTCTATTG ATGACATCAA TCTTTCGGAA 
ACACGGTGCC CTCATCATAT CTGGCATATA AGGAATTTCA CACAGTTCAT TGGCAGCCCA 
AATGGAACTC TGTATAGCCC TCCATTTTAC TCTTCTAAAG GTTATGCCTT TCAGATTTAC 
TTAAATCTAG CCCATGTGAC TAATGCAGGG ATATATTTCC ACTTGATCTC TGGAGCCAAT 
GATGATCAAT TACAGTGGCC ATGTCCTTGG CAACAAGCCA CAATGACACT TTTGGATCAA 
AATCCTGACA TTCGACAGCG TATGTCCAAT CAGCGGAGTA TAACTACAGA CCCATTTATG 
ACCACCGATA ATGGAAACTA TTTCTGGGAC AGGCCTTCTA AAGTGGGAAC AGTGGCTTTG 
TTCTCTAATG GAACTCAGTT TAGAAGAGGT GGGGGCTATG GAACCAGTGC CTTTATAACC 
CACGAAAGGC TGAAAAGCAG AGATTTTATA AAAGGAGATG ATGTTTATAT CCTACTGACA 
GTGGAAGACA TATCTCACCT CAACTCTACA CAAATCCAGC TAACACCAGC CCCTAGTGTT 
CAAGACCTCT GCTCAAAAAC CACCTGTAAA AATGACGGTG TCTGCACTGT TCGAGATGGC 
AAAGCTGAGT GCAGGTGCCA GTCAGGGGAA GACTGGTGGT ACATGGGAGA AAGGTGTGAA 
AAGAGAGGCT CCACCCGAGA CACCATAGTC ATTGCTGTTT CATCTACTGT TGCTGTGTTT 
GCCTTGATGC TGATCATCAC CCTTGTCAGT GTCTATTGCA CCAGGAAGAA ATATCGTGAA 
AGGATGAGCT CAAATCGACC AAATTTGACT CCGCAAAATC AGCATGCTTT TTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MEP1B ( NM_001308171.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001295100.1 Homo sapiens meprin A subunit beta (MEP1B), transcript variant 2, mRNA.

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CloneID	OHu51211
Clone ID Related Accession (Same CDS sequence)	NM_001308171.2 , NM_001308171.1
Accession Version	NM_001308171.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2103bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-27
Organism	Homo sapiens(human)
Product	meprin A subunit beta isoform 2 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from X81333.1, AC011825.13 and AC015563.11. On May 31, 2019 this sequence version replaced NM_001308171.1. Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X81333.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2144835, SAMEA2152474 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGATTTAT GGAATCTGTC TTGGTTTCTG TTCTTGGATG CTCTTCTCGT GATTTCTGGC 
TTGGCAACTC CAGAAAACTT TGATGTAGAT GGCGGAATGG ACCAGGACAT ATTTGATATC 
AATGAAGGTT TGGGACTGGA TCTTTTTGAG GGTGACATCA GACTTGATAG GGCACAAATT 
AGAAATTCCA TCATTGGAGA AAAGTATAGA TGGCCTCATA CCATTCCATA TGTTCTAGAA 
GATAGCTTGG AAATGAATGC TAAGGGAGTT ATCCTCAATG CATTTGAACG TTATCGCCTT 
AAAACATGTA TTGACTTTAA GCCTTGGGCT GGAGAAACAA ACTATATATC AGTGTTCAAG 
GGCAGTGGCT GCTGGTCTTC AGTAGGAAAT AGGCGGGTTG GGAAGCAAGA ACTTTCCATC 
GGGGCAAACT GTGACCGAAT AGCAACAGTT CAACACGAGT TCCTCCACGC TCTGGGATTC 
TGGCATGAGC AGTCGCGTTC TGACCGGGAT GACTATGTCA GGATAATGTG GGACAGAATT 
CTGTCAGGCA GAGAGCACAA TTTTAACACC TATAGTGACG ATATATCAGA TTCCCTGAAT 
GTTCCCTATG ATTACACTTC AGTAATGCAC TACAGTAAAA CTGCATTCCA AAATGGAACA 
GAGCCGACAA TTGTCACAAG AATCTCAGAC TTTGAGGATG TGATCGGCCA ACGAATGGAT 
TTCAGTGACT CTGATCTCCT AAAGTTGAAT CAACTGTATA ACTGCTCCTC TTCCTTGAGT 
TTTATGGACT CGTGCAGTTT TGAACTGGAA AATGTGTGTG GCATGATCCA AAGTTCAGGA 
GATAATGCTG ACTGGCAACG GGTTTCACAG GTTCCCAGGG GGCCAGAGAG TGATCACTCC 
AACATGGGCC AGTGCCAAGG TTCTGGTTTC TTCATGCATT TCGATAGCAG CTCTGTAAAT 
GTGGGGGCCA CAGCAGTGCT GGAAAGTAGA ACGCTGTACC CTAAAAGAGG ATTTCAGTGC 
CTGCAATTTT ACTTATATAA CAGTGGCAGT GAAAGTGATC AACTGAACAT CTATATCAGG 
GAGTATTCTG CAGACAATGT GGATGGCAAT TTAACCCTTG TGGAAGAAAT AAAAGAAATA 
CCCACTGGGA GCTGGCAACT TTATCATGTA ACATTGAAAG TGACCAAGAA GTTTAGAGTG 
GTGTTTGAAG GACGCAAAGG CTCTGGTGCA TCACTGGGTG GTCTGTCTAT TGATGACATC 
AATCTTTCGG AAACACGGTG CCCTCATCAT ATCTGGCATA TAAGGAATTT CACACAGTTC 
ATTGGCAGCC CAAATGGAAC TCTGTATAGC CCTCCATTTT ACTCTTCTAA AGGTTATGCC 
TTTCAGATTT ACTTAAATCT AGCCCATGTG ACTAATGCAG GGATATATTT CCACTTGATC 
TCTGGAGCCA ATGATGATCA ATTACAGTGG CCATGTCCTT GGCAACAAGC CACAATGACA 
CTTTTGGATC AAAATCCTGA CATTCGACAG CGTATGTCCA ATCAGCGGAG TATAACTACA 
GACCCATTTA TGACCACCGA TAATGGAAAC TATTTCTGGG ACAGGCCTTC TAAAGTGGGA 
ACAGTGGCTT TGTTCTCTAA TGGAACTCAG TTTAGAAGAG GTGGGGGCTA TGGAACCAGT 
GCCTTTATAA CCCACGAAAG GCTGAAAAGC AGAGATTTTA TAAAAGGAGA TGATGTTTAT 
ATCCTACTGA CAGTGGAAGA CATATCTCAC CTCAACTCTA CACAAATCCA GCTAACACCA 
GCCCCTAGTG TTCAAGACCT CTGCTCAAAA ACCACCTGTA AAAATGACGG TGTCTGCACT 
GTTCGAGATG GCAAAGCTGA GTGCAGGTGC CAGTCAGGGG AAGACTGGTG GTACATGGGA 
GAAAGGTGTG AAAAGAGAGG CTCCACCCGA GACACCATAG TCATTGCTGT TTCATCTACT 
GTTGCTGTGT TTGCCTTGAT GCTGATCATC ACCCTTGTCA GTGTCTATTG CACCAGGAAG 
AAATATCGTG AAAGGATGAG CTCAAATCGA CCAAATTTGA CTCCGCAAAA TCATGCTTTT 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001295100.1
CDS	33..2135
Translation	MDLWNLSWFLFLDALLVISGLATPENFDVDGGMDQDIFDINEGLGLDLFEGDIRLDRAQIRNSIIGEKYRWPHTIPYVLEDSLEMNAKGVILNAFERYRLKTCIDFKPWAGETNYISVFKGSGCWSSVGNRRVGKQELSIGANCDRIATVQHEFLHALGFWHEQSRSDRDDYVRIMWDRILSGREHNFNTYSDDISDSLNVPYDYTSVMHYSKTAFQNGTEPTIVTRISDFEDVIGQRMDFSDSDLLKLNQLYNCSSSLSFMDSCSFELENVCGMIQSSGDNADWQRVSQVPRGPESDHSNMGQCQGSGFFMHFDSSSVNVGATAVLESRTLYPKRGFQCLQFYLYNSGSESDQLNIYIREYSADNVDGNLTLVEEIKEIPTGSWQLYHVTLKVTKKFRVVFEGRKGSGASLGGLSIDDINLSETRCPHHIWHIRNFTQFIGSPNGTLYSPPFYSSKGYAFQIYLNLAHVTNAGIYFHLISGANDDQLQWPCPWQQATMTLLDQNPDIRQRMSNQRSITTDPFMTTDNGNYFWDRPSKVGTVALFSNGTQFRRGGGYGTSAFITHERLKSRDFIKGDDVYILLTVEDISHLNSTQIQLTPAPSVQDLCSKTTCKNDGVCTVRDGKAECRCQSGEDWWYMGERCEKRGSTRDTIVIAVSSTVAVFALMLIITLVSVYCTRKKYRERMSSNRPNLTPQNHAF

Target ORF information:

RefSeq Version	NM_001308171.2
Organism	Homo sapiens(human)
Definition	Homo sapiens meprin A subunit beta (MEP1B), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001308171.2

ORF Insert Sequence:

ATGGATTTAT GGAATCTGTC TTGGTTTCTG TTCTTGGATG CTCTTCTCGT GATTTCTGGC 
TTGGCAACTC CAGAAAACTT TGATGTAGAT GGCGGAATGG ACCAGGACAT ATTTGATATC 
AATGAAGGTT TGGGACTGGA TCTTTTTGAG GGTGACATCA GACTTGATAG GGCACAAATT 
AGAAATTCCA TCATTGGAGA AAAGTATAGA TGGCCTCATA CCATTCCATA TGTTCTAGAA 
GATAGCTTGG AAATGAATGC TAAGGGAGTT ATCCTCAATG CATTTGAACG TTATCGCCTT 
AAAACATGTA TTGACTTTAA GCCTTGGGCT GGAGAAACAA ACTATATATC AGTGTTCAAG 
GGCAGTGGCT GCTGGTCTTC AGTAGGAAAT AGGCGGGTTG GGAAGCAAGA ACTTTCCATC 
GGGGCAAACT GTGACCGAAT AGCAACAGTT CAACACGAGT TCCTCCACGC TCTGGGATTC 
TGGCATGAGC AGTCGCGTTC TGACCGGGAT GACTATGTCA GGATAATGTG GGACAGAATT 
CTGTCAGGCA GAGAGCACAA TTTTAACACC TATAGTGACG ATATATCAGA TTCCCTGAAT 
GTTCCCTATG ATTACACTTC AGTAATGCAC TACAGTAAAA CTGCATTCCA AAATGGAACA 
GAGCCGACAA TTGTCACAAG AATCTCAGAC TTTGAGGATG TGATCGGCCA ACGAATGGAT 
TTCAGTGACT CTGATCTCCT AAAGTTGAAT CAACTGTATA ACTGCTCCTC TTCCTTGAGT 
TTTATGGACT CGTGCAGTTT TGAACTGGAA AATGTGTGTG GCATGATCCA AAGTTCAGGA 
GATAATGCTG ACTGGCAACG GGTTTCACAG GTTCCCAGGG GGCCAGAGAG TGATCACTCC 
AACATGGGCC AGTGCCAAGG TTCTGGTTTC TTCATGCATT TCGATAGCAG CTCTGTAAAT 
GTGGGGGCCA CAGCAGTGCT GGAAAGTAGA ACGCTGTACC CTAAAAGAGG ATTTCAGTGC 
CTGCAATTTT ACTTATATAA CAGTGGCAGT GAAAGTGATC AACTGAACAT CTATATCAGG 
GAGTATTCTG CAGACAATGT GGATGGCAAT TTAACCCTTG TGGAAGAAAT AAAAGAAATA 
CCCACTGGGA GCTGGCAACT TTATCATGTA ACATTGAAAG TGACCAAGAA GTTTAGAGTG 
GTGTTTGAAG GACGCAAAGG CTCTGGTGCA TCACTGGGTG GTCTGTCTAT TGATGACATC 
AATCTTTCGG AAACACGGTG CCCTCATCAT ATCTGGCATA TAAGGAATTT CACACAGTTC 
ATTGGCAGCC CAAATGGAAC TCTGTATAGC CCTCCATTTT ACTCTTCTAA AGGTTATGCC 
TTTCAGATTT ACTTAAATCT AGCCCATGTG ACTAATGCAG GGATATATTT CCACTTGATC 
TCTGGAGCCA ATGATGATCA ATTACAGTGG CCATGTCCTT GGCAACAAGC CACAATGACA 
CTTTTGGATC AAAATCCTGA CATTCGACAG CGTATGTCCA ATCAGCGGAG TATAACTACA 
GACCCATTTA TGACCACCGA TAATGGAAAC TATTTCTGGG ACAGGCCTTC TAAAGTGGGA 
ACAGTGGCTT TGTTCTCTAA TGGAACTCAG TTTAGAAGAG GTGGGGGCTA TGGAACCAGT 
GCCTTTATAA CCCACGAAAG GCTGAAAAGC AGAGATTTTA TAAAAGGAGA TGATGTTTAT 
ATCCTACTGA CAGTGGAAGA CATATCTCAC CTCAACTCTA CACAAATCCA GCTAACACCA 
GCCCCTAGTG TTCAAGACCT CTGCTCAAAA ACCACCTGTA AAAATGACGG TGTCTGCACT 
GTTCGAGATG GCAAAGCTGA GTGCAGGTGC CAGTCAGGGG AAGACTGGTG GTACATGGGA 
GAAAGGTGTG AAAAGAGAGG CTCCACCCGA GACACCATAG TCATTGCTGT TTCATCTACT 
GTTGCTGTGT TTGCCTTGAT GCTGATCATC ACCCTTGTCA GTGTCTATTG CACCAGGAAG 
AAATATCGTG AAAGGATGAG CTCAAATCGA CCAAATTTGA CTCCGCAAAA TCATGCTTTT 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MEP1B ( NM_001308171.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001295100.1 Homo sapiens meprin A subunit beta (MEP1B), transcript variant 2, mRNA.

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CloneID	OHu51211
Clone ID Related Accession (Same CDS sequence)	NM_001308171.2 , NM_001308171.1
Accession Version	NM_001308171.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2103bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-24
Organism	Homo sapiens(human)
Product	meprin A subunit beta isoform 2 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AY695931.1, X81333.1, AC011825.13 and AC015563.11. On Apr 28, 2015 this sequence version replaced XM_005258275.3. Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X81333.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2144835, SAMEA2152474 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGATTTAT GGAATCTGTC TTGGTTTCTG TTCTTGGATG CTCTTCTCGT GATTTCTGGC 
TTGGCAACTC CAGAAAACTT TGATGTAGAT GGCGGAATGG ACCAGGACAT ATTTGATATC 
AATGAAGGTT TGGGACTGGA TCTTTTTGAG GGTGACATCA GACTTGATAG GGCACAAATT 
AGAAATTCCA TCATTGGAGA AAAGTATAGA TGGCCTCATA CCATTCCATA TGTTCTAGAA 
GATAGCTTGG AAATGAATGC TAAGGGAGTT ATCCTCAATG CATTTGAACG TTATCGCCTT 
AAAACATGTA TTGACTTTAA GCCTTGGGCT GGAGAAACAA ACTATATATC AGTGTTCAAG 
GGCAGTGGCT GCTGGTCTTC AGTAGGAAAT AGGCGGGTTG GGAAGCAAGA ACTTTCCATC 
GGGGCAAACT GTGACCGAAT AGCAACAGTT CAACACGAGT TCCTCCACGC TCTGGGATTC 
TGGCATGAGC AGTCGCGTTC TGACCGGGAT GACTATGTCA GGATAATGTG GGACAGAATT 
CTGTCAGGCA GAGAGCACAA TTTTAACACC TATAGTGACG ATATATCAGA TTCCCTGAAT 
GTTCCCTATG ATTACACTTC AGTAATGCAC TACAGTAAAA CTGCATTCCA AAATGGAACA 
GAGCCGACAA TTGTCACAAG AATCTCAGAC TTTGAGGATG TGATCGGCCA ACGAATGGAT 
TTCAGTGACT CTGATCTCCT AAAGTTGAAT CAACTGTATA ACTGCTCCTC TTCCTTGAGT 
TTTATGGACT CGTGCAGTTT TGAACTGGAA AATGTGTGTG GCATGATCCA AAGTTCAGGA 
GATAATGCTG ACTGGCAACG GGTTTCACAG GTTCCCAGGG GGCCAGAGAG TGATCACTCC 
AACATGGGCC AGTGCCAAGG TTCTGGTTTC TTCATGCATT TCGATAGCAG CTCTGTAAAT 
GTGGGGGCCA CAGCAGTGCT GGAAAGTAGA ACGCTGTACC CTAAAAGAGG ATTTCAGTGC 
CTGCAATTTT ACTTATATAA CAGTGGCAGT GAAAGTGATC AACTGAACAT CTATATCAGG 
GAGTATTCTG CAGACAATGT GGATGGCAAT TTAACCCTTG TGGAAGAAAT AAAAGAAATA 
CCCACTGGGA GCTGGCAACT TTATCATGTA ACATTGAAAG TGACCAAGAA GTTTAGAGTG 
GTGTTTGAAG GACGCAAAGG CTCTGGTGCA TCACTGGGTG GTCTGTCTAT TGATGACATC 
AATCTTTCGG AAACACGGTG CCCTCATCAT ATCTGGCATA TAAGGAATTT CACACAGTTC 
ATTGGCAGCC CAAATGGAAC TCTGTATAGC CCTCCATTTT ACTCTTCTAA AGGTTATGCC 
TTTCAGATTT ACTTAAATCT AGCCCATGTG ACTAATGCAG GGATATATTT CCACTTGATC 
TCTGGAGCCA ATGATGATCA ATTACAGTGG CCATGTCCTT GGCAACAAGC CACAATGACA 
CTTTTGGATC AAAATCCTGA CATTCGACAG CGTATGTCCA ATCAGCGGAG TATAACTACA 
GACCCATTTA TGACCACCGA TAATGGAAAC TATTTCTGGG ACAGGCCTTC TAAAGTGGGA 
ACAGTGGCTT TGTTCTCTAA TGGAACTCAG TTTAGAAGAG GTGGGGGCTA TGGAACCAGT 
GCCTTTATAA CCCACGAAAG GCTGAAAAGC AGAGATTTTA TAAAAGGAGA TGATGTTTAT 
ATCCTACTGA CAGTGGAAGA CATATCTCAC CTCAACTCTA CACAAATCCA GCTAACACCA 
GCCCCTAGTG TTCAAGACCT CTGCTCAAAA ACCACCTGTA AAAATGACGG TGTCTGCACT 
GTTCGAGATG GCAAAGCTGA GTGCAGGTGC CAGTCAGGGG AAGACTGGTG GTACATGGGA 
GAAAGGTGTG AAAAGAGAGG CTCCACCCGA GACACCATAG TCATTGCTGT TTCATCTACT 
GTTGCTGTGT TTGCCTTGAT GCTGATCATC ACCCTTGTCA GTGTCTATTG CACCAGGAAG 
AAATATCGTG AAAGGATGAG CTCAAATCGA CCAAATTTGA CTCCGCAAAA TCATGCTTTT 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001295100.1
CDS	48..2150
Translation	MDLWNLSWFLFLDALLVISGLATPENFDVDGGMDQDIFDINEGLGLDLFEGDIRLDRAQIRNSIIGEKYRWPHTIPYVLEDSLEMNAKGVILNAFERYRLKTCIDFKPWAGETNYISVFKGSGCWSSVGNRRVGKQELSIGANCDRIATVQHEFLHALGFWHEQSRSDRDDYVRIMWDRILSGREHNFNTYSDDISDSLNVPYDYTSVMHYSKTAFQNGTEPTIVTRISDFEDVIGQRMDFSDSDLLKLNQLYNCSSSLSFMDSCSFELENVCGMIQSSGDNADWQRVSQVPRGPESDHSNMGQCQGSGFFMHFDSSSVNVGATAVLESRTLYPKRGFQCLQFYLYNSGSESDQLNIYIREYSADNVDGNLTLVEEIKEIPTGSWQLYHVTLKVTKKFRVVFEGRKGSGASLGGLSIDDINLSETRCPHHIWHIRNFTQFIGSPNGTLYSPPFYSSKGYAFQIYLNLAHVTNAGIYFHLISGANDDQLQWPCPWQQATMTLLDQNPDIRQRMSNQRSITTDPFMTTDNGNYFWDRPSKVGTVALFSNGTQFRRGGGYGTSAFITHERLKSRDFIKGDDVYILLTVEDISHLNSTQIQLTPAPSVQDLCSKTTCKNDGVCTVRDGKAECRCQSGEDWWYMGERCEKRGSTRDTIVIAVSSTVAVFALMLIITLVSVYCTRKKYRERMSSNRPNLTPQNHAF

Target ORF information:

RefSeq Version	NM_001308171.1
Organism	Homo sapiens(human)
Definition	Homo sapiens meprin A subunit beta (MEP1B), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001308171.1

ORF Insert Sequence:

ATGGATTTAT GGAATCTGTC TTGGTTTCTG TTCTTGGATG CTCTTCTCGT GATTTCTGGC 
TTGGCAACTC CAGAAAACTT TGATGTAGAT GGCGGAATGG ACCAGGACAT ATTTGATATC 
AATGAAGGTT TGGGACTGGA TCTTTTTGAG GGTGACATCA GACTTGATAG GGCACAAATT 
AGAAATTCCA TCATTGGAGA AAAGTATAGA TGGCCTCATA CCATTCCATA TGTTCTAGAA 
GATAGCTTGG AAATGAATGC TAAGGGAGTT ATCCTCAATG CATTTGAACG TTATCGCCTT 
AAAACATGTA TTGACTTTAA GCCTTGGGCT GGAGAAACAA ACTATATATC AGTGTTCAAG 
GGCAGTGGCT GCTGGTCTTC AGTAGGAAAT AGGCGGGTTG GGAAGCAAGA ACTTTCCATC 
GGGGCAAACT GTGACCGAAT AGCAACAGTT CAACACGAGT TCCTCCACGC TCTGGGATTC 
TGGCATGAGC AGTCGCGTTC TGACCGGGAT GACTATGTCA GGATAATGTG GGACAGAATT 
CTGTCAGGCA GAGAGCACAA TTTTAACACC TATAGTGACG ATATATCAGA TTCCCTGAAT 
GTTCCCTATG ATTACACTTC AGTAATGCAC TACAGTAAAA CTGCATTCCA AAATGGAACA 
GAGCCGACAA TTGTCACAAG AATCTCAGAC TTTGAGGATG TGATCGGCCA ACGAATGGAT 
TTCAGTGACT CTGATCTCCT AAAGTTGAAT CAACTGTATA ACTGCTCCTC TTCCTTGAGT 
TTTATGGACT CGTGCAGTTT TGAACTGGAA AATGTGTGTG GCATGATCCA AAGTTCAGGA 
GATAATGCTG ACTGGCAACG GGTTTCACAG GTTCCCAGGG GGCCAGAGAG TGATCACTCC 
AACATGGGCC AGTGCCAAGG TTCTGGTTTC TTCATGCATT TCGATAGCAG CTCTGTAAAT 
GTGGGGGCCA CAGCAGTGCT GGAAAGTAGA ACGCTGTACC CTAAAAGAGG ATTTCAGTGC 
CTGCAATTTT ACTTATATAA CAGTGGCAGT GAAAGTGATC AACTGAACAT CTATATCAGG 
GAGTATTCTG CAGACAATGT GGATGGCAAT TTAACCCTTG TGGAAGAAAT AAAAGAAATA 
CCCACTGGGA GCTGGCAACT TTATCATGTA ACATTGAAAG TGACCAAGAA GTTTAGAGTG 
GTGTTTGAAG GACGCAAAGG CTCTGGTGCA TCACTGGGTG GTCTGTCTAT TGATGACATC 
AATCTTTCGG AAACACGGTG CCCTCATCAT ATCTGGCATA TAAGGAATTT CACACAGTTC 
ATTGGCAGCC CAAATGGAAC TCTGTATAGC CCTCCATTTT ACTCTTCTAA AGGTTATGCC 
TTTCAGATTT ACTTAAATCT AGCCCATGTG ACTAATGCAG GGATATATTT CCACTTGATC 
TCTGGAGCCA ATGATGATCA ATTACAGTGG CCATGTCCTT GGCAACAAGC CACAATGACA 
CTTTTGGATC AAAATCCTGA CATTCGACAG CGTATGTCCA ATCAGCGGAG TATAACTACA 
GACCCATTTA TGACCACCGA TAATGGAAAC TATTTCTGGG ACAGGCCTTC TAAAGTGGGA 
ACAGTGGCTT TGTTCTCTAA TGGAACTCAG TTTAGAAGAG GTGGGGGCTA TGGAACCAGT 
GCCTTTATAA CCCACGAAAG GCTGAAAAGC AGAGATTTTA TAAAAGGAGA TGATGTTTAT 
ATCCTACTGA CAGTGGAAGA CATATCTCAC CTCAACTCTA CACAAATCCA GCTAACACCA 
GCCCCTAGTG TTCAAGACCT CTGCTCAAAA ACCACCTGTA AAAATGACGG TGTCTGCACT 
GTTCGAGATG GCAAAGCTGA GTGCAGGTGC CAGTCAGGGG AAGACTGGTG GTACATGGGA 
GAAAGGTGTG AAAAGAGAGG CTCCACCCGA GACACCATAG TCATTGCTGT TTCATCTACT 
GTTGCTGTGT TTGCCTTGAT GCTGATCATC ACCCTTGTCA GTGTCTATTG CACCAGGAAG 
AAATATCGTG AAAGGATGAG CTCAAATCGA CCAAATTTGA CTCCGCAAAA TCATGCTTTT 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Mucus Detachment by Host Metalloprotease Meprin ? Requires Shedding of Its Inactive Pro-form, which Is Abrogated by the Pathogenic Protease RgpB.
Cell reports21(8)2090-2103(2017 Nov)
Wichert R,Ermund A,Schmidt S,Schweinlin M,Ksiazek M,Arnold P,Knittler K,Wilkens F,Potempa B,Rabe B,Stirnberg M,Lucius R,Bartsch JW,Nikolaus S,Falk-Paulsen M,Rosenstiel P,Metzger M,Rose-John S,Potempa J,Hansson GC,Dempsey PJ,Becker-Pauly C

Meprin metalloproteases: Molecular regulation and function in inflammation and fibrosis.
Biochimica et biophysica acta1864(11 Pt B)2096-2104(2017 11)
Arnold P,Otte A,Becker-Pauly C

Meprin ? and BMP-1 are differentially regulated by CaCl
Cell calcium658-13(2017 Jul)
Schneppenheim J,Scharfenberg F,Lucius R,Becker-Pauly C,Arnold P

Meprin ? contributes to collagen deposition in lung fibrosis.
Scientific reports739969(2017 Jan)
Biasin V,Wygrecka M,Marsh LM,Becker-Pauly C,Brcic L,Ghanim B,Klepetko W,Olschewski A,Kwapiszewska G

Tetraspanin 8 is an interactor of the metalloprotease meprin ? within tetraspanin-enriched microdomains.
Biological chemistry397(9)857-69(2016 Sep)
Schmidt F,M?ller M,Prox J,Arnold P,Sch?nherr C,Tredup C,Minder P,Ebsen H,Janssen O,Annaert W,Pietrzik C,Schmidt-Arras D,Sterchi EE,Becker-Pauly C

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MEP1B cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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