MEOX2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	MEOX2
Entrez Gene ID	4223
Full Name	mesenchyme homeobox 2
Synonyms	GAX,MOX2
General protein information	Preferred Names mesenchyme homeobox 2 Names homeobox protein MOX-2 growth arrest-specific homeobox
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 7 Map Location: 7p21.2
Summary	This gene encodes a member of a subfamily of non-clustered, diverged, antennapedia-like homeobox-containing genes. The encoded protein may play a role in the regulation of vertebrate limb myogenesis. Mutations in the related mouse protein may be associated with craniofacial and/or skeletal abnormalities, in addition to neurovascular dysfunction observed in Alzheimer's disease. [provided by RefSeq, Jul 2008].
Disorder MIM:	600535

mRNA and Protein(s)

mRNA	Protein	Name
NM_005924.4	NP_005915.2	homeobox protein MOX-2
NM_005924.5	NP_005915.2	homeobox protein MOX-2

Pathways from BioSystems

Homologies

Bos taurus (cattle)	MEOX2	NP_001091514.1
	MEOX2	XP_001105568.1
Mus musculus (house mouse)	Meox2	NP_032610.1
Danio rerio (zebrafish)	LOC556898	XP_684924.1
Pan troglodytes (chimpanzee)	MEOX2	XP_518979.2
Rattus norvegicus (Norway rat)	Meox2	NP_058845.1
Gallus gallus (chicken)	MEOX2	NP_001005427.1
Xenopus tropicalis (tropical clawed frog)	meox2	NP_001116898.1
Homo sapiens (human)	MEOX2	NP_005915.2
Canis lupus familiaris (dog)	MEOX2	XP_539446.2

Gene Ontology
Bibliography

Related articles in PubMed

Association of MEOX2 polymorphism with nonsyndromic cleft palate only in a Vietnamese population.
Tran DL, Imura H, Mori A, Suzuki S, Niimi T, Ono M, Sakuma C, Nakahara S, Nguyen TTH, Pham PT, Hoang V, Tran VTT, Nguyen MD, Natsume N
Congenital anomalies(2017 Oct)

Mesenchyme Homeobox 2 Enhances Migration of Endothelial Colony Forming Cells Exposed to Intrauterine Diabetes Mellitus.
Gohn CR, Blue EK, Sheehan BM, Varberg KM, Haneline LS
Journal of cellular physiology232(7)1885-1892(2017 Jul)

Role of microRNA-130a in the pathogeneses of obstructive sleep apnea hypopnea syndrome-associated pulmonary hypertension by targeting the GAX gene.
An Z, Wang D, Yang G, Zhang WQ, Ren J, Fu JL
Medicine96(20)e6746(2017 May)

An inter-species protein-protein interaction network across vast evolutionary distance.
Zhong Q, Pevzner SJ, Hao T, Wang Y, Mosca R, Menche J, Taipale M, Ta?an M, Fan C, Yang X, Haley P, Murray RR, Mer F, Gebreab F, Tam S, MacWilliams A, Dricot A, Reichert P, Santhanam B, Ghamsari L, Calderwood MA, Rolland T, Charloteaux B, Lindquist S, Barab?si AL, Hill DE, Aloy P, Cusick ME, Xia Y, Roth FP, Vidal M
Molecular systems biology12(4)865(2016 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

MEOX2 may serve a protective role, enabling increased vessel formation despite exposure to a diabetes mellitus intrauterine environment.
Title: Mesenchyme Homeobox 2 Enhances Migration of Endothelial Colony Forming Cells Exposed to Intrauterine Diabetes Mellitus.

Findings suggest that miR-130a may be involved in the development of obstructive sleep apnea hypopnea syndrome-associated pulmonary hypertension by down-regulating GAX gene
Title: Role of microRNA-130a in the pathogeneses of obstructive sleep apnea hypopnea syndrome-associated pulmonary hypertension by targeting the GAX gene.

Genetic variation in MEOX2, but not TCF15, is a strong predictor of CHD. Further experimental studies should elucidate the underlying molecular mechanisms.
Title: Coronary risk in relation to genetic variation in MEOX2 and TCF15 in a Flemish population.

3D topography transiently induces concomitant upregulation of IL-1beta and MAPK ERK1/2 through nuclear factor-kappaB-dependent signaling pathway.
Title: Activation of Transcription Factor GAX and Concomitant Downregulation of IL-1? and ERK1/2 Modulate Vascular Smooth Muscle Cell Phenotype in 3D Fibrous Scaffolds.

Microarray profiling on freshly isolated ECs had a genetic signature for microvascular heart ECs and identified Meox2/Tcf15 heterodimers as novel transcriptional determinants. This signature was similar in skeletal muscle and adipose tissue endothelium.
Title: Meox2/Tcf15 heterodimers program the heart capillary endothelium for cardiac fatty acid uptake.

The following MEOX2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MEOX2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu17789	NM_005924.5 Latest version!	Homo sapiens mesenchyme homeobox 2 (MEOX2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
View Old Accession Versions >>
OHu17789	NM_005924.4	Homo sapiens mesenchyme homeobox 2 (MEOX2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

MEOX2 ( NM_005924.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_005915.2 Homo sapiens mesenchyme homeobox 2 (MEOX2), mRNA.

Price & Availability↑

CloneID	OHu17789
Clone ID Related Accession (Same CDS sequence)	NM_005924.4 , NM_005924.5
Accession Version	NM_005924.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 915bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-27
Organism	Homo sapiens(human)
Product	homeobox protein MOX-2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA586635.1, BC017021.1 and BQ025060.1. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_005924.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC017021.1, X82629.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2162568, SAMEA2467143 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000262041.6/ ENSP00000262041.5 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGAACACC CGCTCTTTGG CTGCCTGCGC AGCCCTCACG CCACGGCGCA AGGCTTGCAC 
CCGTTCTCCC AATCCTCTCT CGCCCTCCAT GGAAGATCTG ACCATATGTC TTACCCCGAG 
CTCTCTACTT CTTCCTCATC TTGCATAATC GCGGGATACC CCAACGAAGA GGGCATGTTT 
GCCAGCCAGC ATCACAGGGG GCACCACCAC CACCACCACC ACCACCACCA TCACCACCAT 
CAGCAGCAGC AGCACCAGGC TCTGCAAACC AACTGGCACC TCCCGCAGAT GTCTTCCCCA 
CCGAGTGCGG CTCGGCACAG CCTCTGCCTC CAGCCCGACT CTGGAGGGCC CCCAGAGTTG 
GGGAGCAGCC CGCCCGTCCT GTGCTCCAAC TCTTCCAGCT TGGGCTCCAG CACCCCGACT 
GGGGCCGCGT GCGCGCCGGG GGACTACGGC CGCCAGGCAC TGTCACCTGC GGAGGCGGAG 
AAGCGAAGCG GCGGCAAGAG GAAAAGCGAC AGCTCAGACT CCCAGGAAGG AAATTACAAG 
TCAGAAGTCA ACAGCAAACC CAGGAAAGAA AGGACAGCAT TTACCAAAGA GCAAATCAGA 
GAACTTGAAG CAGAATTTGC CCATCATAAT TATCTCACCA GACTGAGGCG ATACGAGATA 
GCAGTGAATC TGGATCTCAC TGAAAGACAG GTGAAAGTCT GGTTCCAAAA CAGGCGGATG 
AAGTGGAAGA GGGTAAAGGG TGGACAGCAA GGAGCTGCGG CTCGGGAAAA GGAACTGGTG 
AATGTGAAAA AGGGAACACT TCTCCCATCA GAGCTGTCGG GAATTGGTGC AGCCACCCTC 
CAGCAAACAG GGGACTCTAT AGCAAATGAA GACAGTCACG ACAGTGACCA CAGCTCAGAG 
CATGCGCACT TATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005915.2
CDS	282..1196
Translation	MEHPLFGCLRSPHATAQGLHPFSQSSLALHGRSDHMSYPELSTSSSSCIIAGYPNEEGMFASQHHRGHHHHHHHHHHHHHQQQQHQALQTNWHLPQMSSPPSAARHSLCLQPDSGGPPELGSSPPVLCSNSSSLGSSTPTGAACAPGDYGRQALSPAEAEKRSGGKRKSDSSDSQEGNYKSEVNSKPRKERTAFTKEQIRELEAEFAHHNYLTRLRRYEIAVNLDLTERQVKVWFQNRRMKWKRVKGGQQGAAAREKELVNVKKGTLLPSELSGIGAATLQQTGDSIANEDSHDSDHSSEHAHL

Target ORF information:

RefSeq Version	NM_005924.5
Organism	Homo sapiens(human)
Definition	Homo sapiens mesenchyme homeobox 2 (MEOX2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005924.5

ORF Insert Sequence:

ATGGAACACC CGCTCTTTGG CTGCCTGCGC AGCCCTCACG CCACGGCGCA AGGCTTGCAC 
CCGTTCTCCC AATCCTCTCT CGCCCTCCAT GGAAGATCTG ACCATATGTC TTACCCCGAG 
CTCTCTACTT CTTCCTCATC TTGCATAATC GCGGGATACC CCAACGAAGA GGGCATGTTT 
GCCAGCCAGC ATCACAGGGG GCACCACCAC CACCACCACC ACCACCACCA TCACCACCAT 
CAGCAGCAGC AGCACCAGGC TCTGCAAACC AACTGGCACC TCCCGCAGAT GTCTTCCCCA 
CCGAGTGCGG CTCGGCACAG CCTCTGCCTC CAGCCCGACT CTGGAGGGCC CCCAGAGTTG 
GGGAGCAGCC CGCCCGTCCT GTGCTCCAAC TCTTCCAGCT TGGGCTCCAG CACCCCGACT 
GGGGCCGCGT GCGCGCCGGG GGACTACGGC CGCCAGGCAC TGTCACCTGC GGAGGCGGAG 
AAGCGAAGCG GCGGCAAGAG GAAAAGCGAC AGCTCAGACT CCCAGGAAGG AAATTACAAG 
TCAGAAGTCA ACAGCAAACC CAGGAAAGAA AGGACAGCAT TTACCAAAGA GCAAATCAGA 
GAACTTGAAG CAGAATTTGC CCATCATAAT TATCTCACCA GACTGAGGCG ATACGAGATA 
GCAGTGAATC TGGATCTCAC TGAAAGACAG GTGAAAGTCT GGTTCCAAAA CAGGCGGATG 
AAGTGGAAGA GGGTAAAGGG TGGACAGCAA GGAGCTGCGG CTCGGGAAAA GGAACTGGTG 
AATGTGAAAA AGGGAACACT TCTCCCATCA GAGCTGTCGG GAATTGGTGC AGCCACCCTC 
CAGCAAACAG GGGACTCTAT AGCAAATGAA GACAGTCACG ACAGTGACCA CAGCTCAGAG 
CATGCGCACT TATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MEOX2 ( NM_005924.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_005915.2 Homo sapiens mesenchyme homeobox 2 (MEOX2), mRNA.

Price & Availability↑

CloneID	OHu17789
Clone ID Related Accession (Same CDS sequence)	NM_005924.4 , NM_005924.5
Accession Version	NM_005924.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 915bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-05
Organism	Homo sapiens(human)
Product	homeobox protein MOX-2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA586635.1, BC017021.1 and BQ025060.1. This sequence is a reference standard in the RefSeqGene project. On Dec 30, 2005 this sequence version replaced NM_005924.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC017021.1, X82629.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2162568, SAMEA2467143 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAACACC CGCTCTTTGG CTGCCTGCGC AGCCCTCACG CCACGGCGCA AGGCTTGCAC 
CCGTTCTCCC AATCCTCTCT CGCCCTCCAT GGAAGATCTG ACCATATGTC TTACCCCGAG 
CTCTCTACTT CTTCCTCATC TTGCATAATC GCGGGATACC CCAACGAAGA GGGCATGTTT 
GCCAGCCAGC ATCACAGGGG GCACCACCAC CACCACCACC ACCACCACCA TCACCACCAT 
CAGCAGCAGC AGCACCAGGC TCTGCAAACC AACTGGCACC TCCCGCAGAT GTCTTCCCCA 
CCGAGTGCGG CTCGGCACAG CCTCTGCCTC CAGCCCGACT CTGGAGGGCC CCCAGAGTTG 
GGGAGCAGCC CGCCCGTCCT GTGCTCCAAC TCTTCCAGCT TGGGCTCCAG CACCCCGACT 
GGGGCCGCGT GCGCGCCGGG GGACTACGGC CGCCAGGCAC TGTCACCTGC GGAGGCGGAG 
AAGCGAAGCG GCGGCAAGAG GAAAAGCGAC AGCTCAGACT CCCAGGAAGG AAATTACAAG 
TCAGAAGTCA ACAGCAAACC CAGGAAAGAA AGGACAGCAT TTACCAAAGA GCAAATCAGA 
GAACTTGAAG CAGAATTTGC CCATCATAAT TATCTCACCA GACTGAGGCG ATACGAGATA 
GCAGTGAATC TGGATCTCAC TGAAAGACAG GTGAAAGTCT GGTTCCAAAA CAGGCGGATG 
AAGTGGAAGA GGGTAAAGGG TGGACAGCAA GGAGCTGCGG CTCGGGAAAA GGAACTGGTG 
AATGTGAAAA AGGGAACACT TCTCCCATCA GAGCTGTCGG GAATTGGTGC AGCCACCCTC 
CAGCAAACAG GGGACTCTAT AGCAAATGAA GACAGTCACG ACAGTGACCA CAGCTCAGAG 
CATGCGCACT TATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005915.2
CDS	282..1196
Translation	MEHPLFGCLRSPHATAQGLHPFSQSSLALHGRSDHMSYPELSTSSSSCIIAGYPNEEGMFASQHHRGHHHHHHHHHHHHHQQQQHQALQTNWHLPQMSSPPSAARHSLCLQPDSGGPPELGSSPPVLCSNSSSLGSSTPTGAACAPGDYGRQALSPAEAEKRSGGKRKSDSSDSQEGNYKSEVNSKPRKERTAFTKEQIRELEAEFAHHNYLTRLRRYEIAVNLDLTERQVKVWFQNRRMKWKRVKGGQQGAAAREKELVNVKKGTLLPSELSGIGAATLQQTGDSIANEDSHDSDHSSEHAHL

Target ORF information:

RefSeq Version	NM_005924.4
Organism	Homo sapiens(human)
Definition	Homo sapiens mesenchyme homeobox 2 (MEOX2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005924.4

ORF Insert Sequence:

ATGGAACACC CGCTCTTTGG CTGCCTGCGC AGCCCTCACG CCACGGCGCA AGGCTTGCAC 
CCGTTCTCCC AATCCTCTCT CGCCCTCCAT GGAAGATCTG ACCATATGTC TTACCCCGAG 
CTCTCTACTT CTTCCTCATC TTGCATAATC GCGGGATACC CCAACGAAGA GGGCATGTTT 
GCCAGCCAGC ATCACAGGGG GCACCACCAC CACCACCACC ACCACCACCA TCACCACCAT 
CAGCAGCAGC AGCACCAGGC TCTGCAAACC AACTGGCACC TCCCGCAGAT GTCTTCCCCA 
CCGAGTGCGG CTCGGCACAG CCTCTGCCTC CAGCCCGACT CTGGAGGGCC CCCAGAGTTG 
GGGAGCAGCC CGCCCGTCCT GTGCTCCAAC TCTTCCAGCT TGGGCTCCAG CACCCCGACT 
GGGGCCGCGT GCGCGCCGGG GGACTACGGC CGCCAGGCAC TGTCACCTGC GGAGGCGGAG 
AAGCGAAGCG GCGGCAAGAG GAAAAGCGAC AGCTCAGACT CCCAGGAAGG AAATTACAAG 
TCAGAAGTCA ACAGCAAACC CAGGAAAGAA AGGACAGCAT TTACCAAAGA GCAAATCAGA 
GAACTTGAAG CAGAATTTGC CCATCATAAT TATCTCACCA GACTGAGGCG ATACGAGATA 
GCAGTGAATC TGGATCTCAC TGAAAGACAG GTGAAAGTCT GGTTCCAAAA CAGGCGGATG 
AAGTGGAAGA GGGTAAAGGG TGGACAGCAA GGAGCTGCGG CTCGGGAAAA GGAACTGGTG 
AATGTGAAAA AGGGAACACT TCTCCCATCA GAGCTGTCGG GAATTGGTGC AGCCACCCTC 
CAGCAAACAG GGGACTCTAT AGCAAATGAA GACAGTCACG ACAGTGACCA CAGCTCAGAG 
CATGCGCACT TATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Association of MEOX2 polymorphism with nonsyndromic cleft palate only in a Vietnamese population.
Congenital anomalies(2017 Oct)
Tran DL,Imura H,Mori A,Suzuki S,Niimi T,Ono M,Sakuma C,Nakahara S,Nguyen TTH,Pham PT,Hoang V,Tran VTT,Nguyen MD,Natsume N

Mesenchyme Homeobox 2 Enhances Migration of Endothelial Colony Forming Cells Exposed to Intrauterine Diabetes Mellitus.
Journal of cellular physiology232(7)1885-1892(2017 Jul)
Gohn CR,Blue EK,Sheehan BM,Varberg KM,Haneline LS

Role of microRNA-130a in the pathogeneses of obstructive sleep apnea hypopnea syndrome-associated pulmonary hypertension by targeting the GAX gene.
Medicine96(20)e6746(2017 May)
An Z,Wang D,Yang G,Zhang WQ,Ren J,Fu JL

An inter-species protein-protein interaction network across vast evolutionary distance.
Molecular systems biology12(4)865(2016 Apr)
Zhong Q,Pevzner SJ,Hao T,Wang Y,Mosca R,Menche J,Taipale M,Ta?an M,Fan C,Yang X,Haley P,Murray RR,Mer F,Gebreab F,Tam S,MacWilliams A,Dricot A,Reichert P,Santhanam B,Ghamsari L,Calderwood MA,Rolland T,Charloteaux B,Lindquist S,Barab?si AL,Hill DE,Aloy P,Cusick ME,Xia Y,Roth FP,Vidal M

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MEOX2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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