SMCP cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	SMCP
Entrez Gene ID	4184
Full Name	sperm mitochondria associated cysteine rich protein
Synonyms	HSMCSGEN1,MCS,MCSP
General protein information	Preferred Names sperm mitochondria associated cysteine rich protein Names sperm mitochondrial-associated cysteine-rich protein testicular tissue protein Li 119 testicular tissue protein Li 161
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1q21.3
Summary	Sperm mitochondria differ in morphology and subcellular localization from those of somatic cells. They are elongated, flattened, and arranged circumferentially to form a helical coiled sheath in the midpiece of the sperm flagellum. The protein encoded by this gene localizes to the capsule associated with the mitochondrial outer membranes and is thought to function in the organization and stabilization of the helical structure of the sperm's mitochondrial sheath. [provided by RefSeq, Jul 2008].
Disorder MIM:	601148

mRNA and Protein(s)

mRNA	Protein	Name
NM_030663.3	NP_109588.2	sperm mitochondrial-associated cysteine-rich protein
NM_030663.2	NP_109588.2	sperm mitochondrial-associated cysteine-rich protein

Pathways from BioSystems

Homologies

	SMCP	NP_001132932.1
Pan troglodytes (chimpanzee)	SMCP	XP_514429.3
Homo sapiens (human)	SMCP	NP_109588.2

Gene Ontology
Bibliography

Related articles in PubMed

Ectopically expressed variant form of sperm mitochondria-associated cysteine-rich protein augments tumorigenicity of the stem cell population of lung adenocarcinoma cells.
Takahashi A, Hirohashi Y, Torigoe T, Tamura Y, Tsukahara T, Kanaseki T, Kochin V, Saijo H, Kubo T, Nakatsugawa M, Asanuma H, Hasegawa T, Kondo T, Sato N
PloS one8(11)e69095(2013)

Non-invasive genetic diagnosis of male infertility using spermatozoal RNA: KLHL10 mutations in oligozoospermic patients impair homodimerization.
Yatsenko AN, Roy A, Chen R, Ma L, Murthy LJ, Yan W, Lamb DJ, Matzuk MM
Human molecular genetics15(23)3411-9(2006 Dec)

Comparative genomics of the sperm mitochondria-associated cysteine-rich protein gene.
Hawthorne SK, Goodarzi G, Bagarova J, Gallant KE, Busanelli RR, Olend WJ, Kleene KC
Genomics87(3)382-91(2006 Mar)

Mammalian selenium-containing proteins.
Behne D, Kyriakopoulos A
Annual review of nutrition21453-73(2001)

Developmental expression, intracellular localization, and selenium content of the cysteine-rich protein associated with the mitochondrial capsules of mouse sperm.
Cataldo L, Baig K, Oko R, Mastrangelo MA, Kleene KC
Molecular reproduction and development45(3)320-31(1996 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

the initiation results indicate that an ectopically expressed variant form of SMCP has a role in tumor initiation of CSCs/CICs and that the variant form of SMCP might be a novel CSC/CIC marker
Title: Ectopically expressed variant form of sperm mitochondria-associated cysteine-rich protein augments tumorigenicity of the stem cell population of lung adenocarcinoma cells.

The levels of SMCP mRNA in human are much lower than in other mammals.
Title: Comparative genomics of the sperm mitochondria-associated cysteine-rich protein gene.

The following SMCP gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SMCP cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu30467	NM_030663.3 Latest version!	Homo sapiens sperm mitochondria associated cysteine rich protein (SMCP), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu30467	NM_030663.2	Homo sapiens sperm mitochondria associated cysteine rich protein (SMCP), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

SMCP ( NM_030663.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_109588.2 Homo sapiens sperm mitochondria associated cysteine rich protein (SMCP), mRNA.

Price & Availability↑

CloneID	OHu30467
Clone ID Related Accession (Same CDS sequence)	NM_030663.3 , NM_030663.2
Accession Version	NM_030663.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 351bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-26
Organism	Homo sapiens(human)
Product	sperm mitochondrial-associated cysteine-rich protein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC014593.2. On Nov 23, 2018 this sequence version replaced NM_030663.2. ##Evidence-Data-START## Transcript exon combination :: BC014593.2, HM005432.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2148093 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology MANE Ensembl match :: ENST00000368765.4/ ENSP00000357754.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGTGTGACC AGACAAAACA CAGTAAATGC TGCCCAGCAA AAGGCAATCA ATGCTGCCCA 
CCACAGCAGA ACCAGTGCTG CCAGTCAAAA GGCAATCAAT GCTGCCCACC AAAACAGAAC 
CAGTGCTGCC AGCCAAAAGG CAGTCAATGC TGCCCACCAA AACACAATCA CTGCTGCCAG 
CCAAAACCCC CATGCTGCAT TCAGGCCAGG TGCTGTGGTT TGGAGACCAA GCCTGAAGTC 
TCACCCCTTA ACATGGAGTC TGAGCCCAAC TCACCGCAAA CTCAGGACAA GGGCTGTCAA 
ACCCAGCAGC AGCCCCATAG CCCACAAAAT GAGTCCAGGC CAAGCAAATG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_109588.2
CDS	146..496
Translation	MCDQTKHSKCCPAKGNQCCPPQQNQCCQSKGNQCCPPKQNQCCQPKGSQCCPPKHNHCCQPKPPCCIQARCCGLETKPEVSPLNMESEPNSPQTQDKGCQTQQQPHSPQNESRPSK

Target ORF information:

RefSeq Version	NM_030663.3
Organism	Homo sapiens(human)
Definition	Homo sapiens sperm mitochondria associated cysteine rich protein (SMCP), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_030663.3

ORF Insert Sequence:

ATGTGTGACC AGACAAAACA CAGTAAATGC TGCCCAGCAA AAGGCAATCA ATGCTGCCCA 
CCACAGCAGA ACCAGTGCTG CCAGTCAAAA GGCAATCAAT GCTGCCCACC AAAACAGAAC 
CAGTGCTGCC AGCCAAAAGG CAGTCAATGC TGCCCACCAA AACACAATCA CTGCTGCCAG 
CCAAAACCCC CATGCTGCAT TCAGGCCAGG TGCTGTGGTT TGGAGACCAA GCCTGAAGTC 
TCACCCCTTA ACATGGAGTC TGAGCCCAAC TCACCGCAAA CTCAGGACAA GGGCTGTCAA 
ACCCAGCAGC AGCCCCATAG CCCACAAAAT GAGTCCAGGC CAAGCAAATG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SMCP ( NM_030663.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_109588.2 Homo sapiens sperm mitochondria associated cysteine rich protein (SMCP), mRNA.

Price & Availability↑

CloneID	OHu30467
Clone ID Related Accession (Same CDS sequence)	NM_030663.3 , NM_030663.2
Accession Version	NM_030663.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 351bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-30
Organism	Homo sapiens(human)
Product	sperm mitochondrial-associated cysteine-rich protein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC014593.2. On Nov 19, 2002 this sequence version replaced NM_030663.1. ##Evidence-Data-START## Transcript exon combination :: BC014593.2, HM005432.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2148093 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGTGTGACC AGACAAAACA CAGTAAATGC TGCCCAGCAA AAGGCAATCA ATGCTGCCCA 
CCACAGCAGA ACCAGTGCTG CCAGTCAAAA GGCAATCAAT GCTGCCCACC AAAACAGAAC 
CAGTGCTGCC AGCCAAAAGG CAGTCAATGC TGCCCACCAA AACACAATCA CTGCTGCCAG 
CCAAAACCCC CATGCTGCAT TCAGGCCAGG TGCTGTGGTT TGGAGACCAA GCCTGAAGTC 
TCACCCCTTA ACATGGAGTC TGAGCCCAAC TCACCGCAAA CTCAGGACAA GGGCTGTCAA 
ACCCAGCAGC AGCCCCATAG CCCACAAAAT GAGTCCAGGC CAAGCAAATG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_109588.2
CDS	146..496
Translation	MCDQTKHSKCCPAKGNQCCPPQQNQCCQSKGNQCCPPKQNQCCQPKGSQCCPPKHNHCCQPKPPCCIQARCCGLETKPEVSPLNMESEPNSPQTQDKGCQTQQQPHSPQNESRPSK

Target ORF information:

RefSeq Version	NM_030663.2
Organism	Homo sapiens(human)
Definition	Homo sapiens sperm mitochondria associated cysteine rich protein (SMCP), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_030663.2

ORF Insert Sequence:

ATGTGTGACC AGACAAAACA CAGTAAATGC TGCCCAGCAA AAGGCAATCA ATGCTGCCCA 
CCACAGCAGA ACCAGTGCTG CCAGTCAAAA GGCAATCAAT GCTGCCCACC AAAACAGAAC 
CAGTGCTGCC AGCCAAAAGG CAGTCAATGC TGCCCACCAA AACACAATCA CTGCTGCCAG 
CCAAAACCCC CATGCTGCAT TCAGGCCAGG TGCTGTGGTT TGGAGACCAA GCCTGAAGTC 
TCACCCCTTA ACATGGAGTC TGAGCCCAAC TCACCGCAAA CTCAGGACAA GGGCTGTCAA 
ACCCAGCAGC AGCCCCATAG CCCACAAAAT GAGTCCAGGC CAAGCAAATG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Ectopically expressed variant form of sperm mitochondria-associated cysteine-rich protein augments tumorigenicity of the stem cell population of lung adenocarcinoma cells.
PloS one8(11)e69095(2013)
Takahashi A,Hirohashi Y,Torigoe T,Tamura Y,Tsukahara T,Kanaseki T,Kochin V,Saijo H,Kubo T,Nakatsugawa M,Asanuma H,Hasegawa T,Kondo T,Sato N

Non-invasive genetic diagnosis of male infertility using spermatozoal RNA: KLHL10 mutations in oligozoospermic patients impair homodimerization.
Human molecular genetics15(23)3411-9(2006 Dec)
Yatsenko AN,Roy A,Chen R,Ma L,Murthy LJ,Yan W,Lamb DJ,Matzuk MM

Comparative genomics of the sperm mitochondria-associated cysteine-rich protein gene.
Genomics87(3)382-91(2006 Mar)
Hawthorne SK,Goodarzi G,Bagarova J,Gallant KE,Busanelli RR,Olend WJ,Kleene KC

Mammalian selenium-containing proteins.
Annual review of nutrition21453-73(2001)
Behne D,Kyriakopoulos A

Developmental expression, intracellular localization, and selenium content of the cysteine-rich protein associated with the mitochondrial capsules of mouse sperm.
Molecular reproduction and development45(3)320-31(1996 Nov)
Cataldo L,Baig K,Oko R,Mastrangelo MA,Kleene KC

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SMCP cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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