MCM4 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	MCM4
Entrez Gene ID	4173
Full Name	minichromosome maintenance complex component 4
Synonyms	CDC21,CDC54,NKCD,NKGCD,P1-CDC21,hCdc21
General protein information	Preferred Names minichromosome maintenance complex component 4 Names DNA replication licensing factor MCM4 CDC21 homolog homolog of S. pombe cell devision cycle 21 minichromosome maintenance deficient 4
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 8 Map Location: 8q11.21
Summary	The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 6 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of this protein by CDC2 kinase reduces the DNA helicase activity and chromatin binding of the MCM complex. This gene is mapped to a region on the chromosome 8 head-to-head next to the PRKDC/DNA-PK, a DNA-activated protein kinase involved in the repair of DNA double-strand breaks. Alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008].
Disorder MIM:	602638
Disorder Html:	Natural killer cell and glucocorticoid deficiency with DNA repair defect, 609981 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_005914.3	NP_005905.2	DNA replication licensing factor MCM4
NM_005914.4	NP_005905.2	DNA replication licensing factor MCM4
NM_182746.3	NP_877423.1	DNA replication licensing factor MCM4
NM_182746.2	NP_877423.1	DNA replication licensing factor MCM4

Pathways from BioSystems

Homologies

Gallus gallus (chicken)	MCM4	XP_424376.2
Arabidopsis thaliana (thale cress)	MCM4	NP_179236.3
Pan troglodytes (chimpanzee)	MCM4	XP_528129.2
Canis lupus familiaris (dog)	MCM4	XP_535063.3
Mus musculus (house mouse)	Mcm4	NP_032591.3
Rattus norvegicus (Norway rat)	Mcm4	NP_387500.1
Eremothecium gossypii	AGOS_ADL026W	NP_984071.2
Magnaporthe oryzae (rice blast fungus)	MGG_09293	XP_003709942.1
Xenopus tropicalis (tropical clawed frog)	mcm4	NP_001005655.1
Bos taurus (cattle)	MCM4	NP_001068626.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP004956	XP_315054.2
Homo sapiens (human)	MCM4	NP_005905.2
	MCM4	XP_002805376.1
Danio rerio (zebrafish)	mcm4	NP_944595.2
Schizosaccharomyces pombe (fission yeast)	mcm4	NP_588004.2
Drosophila melanogaster (fruit fly)	dpa	NP_477185.1
Caenorhabditis elegans (roundworm)	mcm-4	NP_490962.1
Saccharomyces cerevisiae (baker's yeast)	MCM4	NP_015344.1
Kluyveromyces lactis	KLLA0C17512g	XP_452982.1
Neurospora crassa	NCU02539	XP_965670.1

Gene Ontology
Bibliography

Related articles in PubMed

Minichromosome maintenance (MCM) protein 4 overexpression is a potential prognostic marker for laryngeal squamous cell carcinoma.
Han J, Lian M, Fang J, Liu H, Wang R, Zhai J, Fan Yang Y, Fen L, Shi Q, Zhi Ma H, Sun J, Ma Z
Journal of B.U.ON. : official journal of the Balkan Union of Oncology22(5)1272-1277(2017 Sep-Oct)

Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)

An MCM4 mutation detected in cancer cells affects MCM4/6/7 complex formation.
Tatsumi R, Ishimi Y
Journal of biochemistry161(3)259-268(2017 Mar)

MCM4 and MCM7, potential novel proliferation markers, significantly correlated with Ki-67, Bmi1, and cyclin E expression in esophageal adenocarcinoma, squamous cell carcinoma, and precancerous lesions.
Choy B, LaLonde A, Que J, Wu T, Zhou Z
Human pathology57126-135(2016 11)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

This MCM4 mutation affected human MCM4/6/7 complex formation, since the complex containing the mutant MCM4 protein is unstable and the mutant MCM4 protein is tend to be degraded.
Title: An MCM4 mutation detected in cancer cells affects MCM4/6/7 complex formation.

MCM4 and MCM7 expression is significantly correlated with Ki-67, Bmi1, and cyclin E expression in esophageal adenocarcinoma, squamous cell carcinoma and precancerous lesions.
Title: MCM4 and MCM7, potential novel proliferation markers, significantly correlated with Ki-67, Bmi1, and cyclin E expression in esophageal adenocarcinoma, squamous cell carcinoma, and precancerous lesions.

We did not find any evidence of augmented response to a short-term (48 h) cisplatin treatment in these MCM4-deficient cells. However, MCM4-/HPV16+ SiHa cells cannot withstand a prolonged treatment (up to 5 days) of even a sublethal dosage of cisplatin
Title: HPV-type-specific response of cervical cancer cells to cisplatin after silencing replication licensing factor MCM4.

Purified MCM4/6/7 complex containing the G364R MCM4 exhibited similar levels of single-stranded DNA binding and ATPase activities to the complex containing wild-type MCM4
Title: G364R mutation of MCM4 detected in human skin cancer cells affects DNA helicase activity of MCM4/6/7 complex.

Mutant p53 depletion profoundly influenced PARP1 localization and increased the level of PCNA and MCM4 proteins.
Title: Proteome-wide analysis of mutant p53 targets in breast cancer identifies new levels of gain-of-function that influence PARP, PCNA, and MCM4.

The following MCM4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MCM4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu11591	NM_005914.4 Latest version!	Homo sapiens minichromosome maintenance complex component 4 (MCM4), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu11591	NM_182746.3 Latest version!	Homo sapiens minichromosome maintenance complex component 4 (MCM4), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
View Old Accession Versions >>
OHu11591	NM_005914.3	Homo sapiens minichromosome maintenance complex component 4 (MCM4), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu11591	NM_182746.2	Homo sapiens minichromosome maintenance complex component 4 (MCM4), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

MCM4 ( NM_005914.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_005905.2 Homo sapiens minichromosome maintenance complex component 4 (MCM4), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu11591
Clone ID Related Accession (Same CDS sequence)	NM_005914.3 , NM_005914.4 , NM_182746.3 , NM_182746.2
Accession Version	NM_005914.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2592bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-09
Organism	Homo sapiens(human)
Product	DNA replication licensing factor MCM4
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC021236.10, BC031061.1, BQ689703.1, AK296913.1 and BF793151.1. This sequence is a reference standard in the RefSeqGene project. On Mar 10, 2011 this sequence version replaced NM_005914.2. Transcript Variant: This variant (1) represents a longer transcript and differs in the 5' UTR, as compared to variant 2. Both variants encode the same protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660807.32608.1, SRR1660807.164419.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

ATGTCGTCCC CGGCGTCGAC CCCGAGCCGC CGCGGCAGCC GGCGTGGAAG GGCCACCCCC 
GCCCAGACGC CTCGGAGTGA GGATGCCAGG TCATCTCCCT CTCAGAGACG TAGAGGCGAG 
GATTCCACCT CCACGGGGGA GTTGCAGCCG ATGCCAACCT CGCCTGGAGT GGACCTGCAG 
AGCCCTGCTG CGCAGGACGT GCTGTTTTCC AGCCCTCCCC AAATGCATTC TTCAGCTATC 
CCTCTTGACT TTGATGTTAG TTCACCACTG ACATACGGCA CTCCCAGCTC TCGGGTAGAG 
GGAACCCCAA GAAGTGGTGT TAGGGGCACA CCTGTGAGAC AGAGGCCTGA CCTGGGCTCT 
GCACAGAAGG GCCTGCAAGT GGATCTGCAG TCTGACGGGG CAGCAGCAGA AGATATAGTG 
GCAAGTGAGC AGTCTCTAGG CCAAAAACTT GTGATCTGGG GAACAGATGT AAATGTGGCA 
GCATGCAAAG AAAACTTTCA GAGATTTCTT CAGCGTTTTA TTGACCCTCT GGCTAAAGAA 
GAAGAAAATG TTGGCATAGA TATTACTGAA CCTCTATACA TGCAACGACT TGGGGAGATT 
AATGTTATTG GTGAGCCATT TTTAAATGTG AACTGTGAAC ACATCAAATC ATTTGACAAA 
AATTTGTACA GACAACTCAT CTCTTACCCA CAGGAAGTTA TTCCAACTTT TGACATGGCT 
GTCAATGAAA TCTTCTTTGA CCGTTACCCT GACTCAATCT TAGAACATCA GATTCAAGTA 
AGACCATTCA ACGCATTGAA GACTAAGAAT ATGAGAAACC TGAATCCAGA AGACATTGAC 
CAGCTCATCA CCATCAGCGG CATGGTGATC AGGACATCCC AGCTGATTCC CGAGATGCAG 
GAGGCCTTCT TCCAGTGCCA AGTGTGTGCC CACACGACCC GGGTGGAGAT GGACCGCGGC 
CGCATTGCAG AGCCCAGTGT GTGCGGGCGC TGCCACACCA CCCACAGCAT GGCACTCATC 
CACAACCGCT CCCTCTTCTC TGACAAGCAG ATGATCAAGC TTCAGGAGTC TCCGGAAGAC 
ATGCCTGCAG GGCAGACACC ACACACAGTT ATCCTGTTTG CTCACAATGA TCTCGTTGAC 
AAGGTCCAGC CTGGGGACAG AGTGAATGTT ACAGGCATCT ATCGAGCTGT GCCTATTCGA 
GTCAATCCAA GAGTGAGTAA TGTGAAGTCT GTCTACAAAA CCCACATTGA TGTCATTCAT 
TATCGGAAAA CGGATGCAAA ACGTCTGCAT GGCCTTGATG AAGAAGCAGA ACAGAAACTT 
TTTTCAGAGA AACGTGTGGA ATTGCTTAAG GAACTTTCCA GGAAACCAGA CATTTATGAG 
AGGCTTGCTT CAGCCTTGGC TCCAAGCATT TATGAACATG AAGATATAAA GAAGGGAATT 
TTGCTTCAGC TCTTTGGCGG GACAAGGAAG GATTTTAGTC ACACTGGAAG GGGCAAATTT 
CGGGCTGAGA TCAACATCTT GCTGTGTGGC GACCCTGGTA CCAGCAAGTC CCAGCTGCTG 
CAGTACGTGT ACAACCTCGT CCCCAGGGGC CAGTACACGT CTGGGAAGGG CTCCAGTGCA 
GTTGGCCTCA CTGCGTACGT AATGAAAGAC CCTGAGACAA GGCAGCTGGT CCTGCAGACA 
GGTGCTCTTG TCCTGAGTGA CAACGGCATC TGCTGTATCG ATGAGTTCGA CAAGATGAAT 
GAAAGTACAA GATCGGTATT GCATGAAGTC ATGGAACAGC AGACTCTGTC CATTGCAAAG 
GCTGGGATCA TCTGTCAGCT CAATGCGCGC ACCTCTGTCC TGGCAGCAGC AAATCCCATT 
GAGTCTCAGT GGAATCCTAA AAAAACAACC ATTGAAAACA TCCAGCTGCC TCATACTTTA 
TTATCAAGGT TTGATTTGAT CTTCCTCTTG CTGGACCCTC AGGACGAAGC CTATGACAGG 
CGTCTGGCTC ACCACCTGGT CGCACTGTAC TACCAGAGCG AGGAGCAGGC AGAGGAGGAG 
CTCCTGGACA TGGCGGTGCT AAAGGACTAC ATTGCCTACG CGCACAGCAC CATCATGCCG 
CGGCTAAGTG AGGAAGCCAG CCAGGCTCTC ATCGAGGCTT ATGTAGACAT GAGGAAGATT 
GGCAGTAGCC GGGGAATGGT TTCTGCATAC CCTCGACAGC TAGAGTCATT AATCCGCTTA 
GCAGAAGCCC ATGCTAAAGT AAGATTGTCT AACAAAGTTG AAGCCATTGA TGTGGAAGAG 
GCCAAACGCC TCCATCGGGA AGCTCTGAAG CAGTCTGCAA CTGATCCCCG GACTGGCATC 
GTGGACATAT CTATTCTTAC TACGGGGATG AGTGCCACCT CTCGTAAACG GAAAGAAGAA 
TTAGCTGAAG CATTGAAAAA GCTTATTTTA TCTAAGGGCA AAACACCAGC TCTAAAATAC 
CAGCAACTTT TTGAAGATAT TCGGGGACAA TCTGACATAG CAATTACTAA AGATATGTTT 
GAAGAAGCAC TGCGTGCCCT GGCAGATGAT GATTTCCTGA CAGTGACTGG GAAGACCGTG 
CGCTTGCTCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005905.2
CDS	943..3534
Translation	MSSPASTPSRRGSRRGRATPAQTPRSEDARSSPSQRRRGEDSTSTGELQPMPTSPGVDLQSPAAQDVLFSSPPQMHSSAIPLDFDVSSPLTYGTPSSRVEGTPRSGVRGTPVRQRPDLGSAQKGLQVDLQSDGAAAEDIVASEQSLGQKLVIWGTDVNVAACKENFQRFLQRFIDPLAKEEENVGIDITEPLYMQRLGEINVIGEPFLNVNCEHIKSFDKNLYRQLISYPQEVIPTFDMAVNEIFFDRYPDSILEHQIQVRPFNALKTKNMRNLNPEDIDQLITISGMVIRTSQLIPEMQEAFFQCQVCAHTTRVEMDRGRIAEPSVCGRCHTTHSMALIHNRSLFSDKQMIKLQESPEDMPAGQTPHTVILFAHNDLVDKVQPGDRVNVTGIYRAVPIRVNPRVSNVKSVYKTHIDVIHYRKTDAKRLHGLDEEAEQKLFSEKRVELLKELSRKPDIYERLASALAPSIYEHEDIKKGILLQLFGGTRKDFSHTGRGKFRAEINILLCGDPGTSKSQLLQYVYNLVPRGQYTSGKGSSAVGLTAYVMKDPETRQLVLQTGALVLSDNGICCIDEFDKMNESTRSVLHEVMEQQTLSIAKAGIICQLNARTSVLAAANPIESQWNPKKTTIENIQLPHTLLSRFDLIFLLLDPQDEAYDRRLAHHLVALYYQSEEQAEEELLDMAVLKDYIAYAHSTIMPRLSEEASQALIEAYVDMRKIGSSRGMVSAYPRQLESLIRLAEAHAKVRLSNKVEAIDVEEAKRLHREALKQSATDPRTGIVDISILTTGMSATSRKRKEELAEALKKLILSKGKTPALKYQQLFEDIRGQSDIAITKDMFEEALRALADDDFLTVTGKTVRLL

Target ORF information:

RefSeq Version	NM_005914.3
Organism	Homo sapiens(human)
Definition	Homo sapiens minichromosome maintenance complex component 4 (MCM4), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005914.3

ORF Insert Sequence:

ATGTCGTCCC CGGCGTCGAC CCCGAGCCGC CGCGGCAGCC GGCGTGGAAG GGCCACCCCC 
GCCCAGACGC CTCGGAGTGA GGATGCCAGG TCATCTCCCT CTCAGAGACG TAGAGGCGAG 
GATTCCACCT CCACGGGGGA GTTGCAGCCG ATGCCAACCT CGCCTGGAGT GGACCTGCAG 
AGCCCTGCTG CGCAGGACGT GCTGTTTTCC AGCCCTCCCC AAATGCATTC TTCAGCTATC 
CCTCTTGACT TTGATGTTAG TTCACCACTG ACATACGGCA CTCCCAGCTC TCGGGTAGAG 
GGAACCCCAA GAAGTGGTGT TAGGGGCACA CCTGTGAGAC AGAGGCCTGA CCTGGGCTCT 
GCACAGAAGG GCCTGCAAGT GGATCTGCAG TCTGACGGGG CAGCAGCAGA AGATATAGTG 
GCAAGTGAGC AGTCTCTAGG CCAAAAACTT GTGATCTGGG GAACAGATGT AAATGTGGCA 
GCATGCAAAG AAAACTTTCA GAGATTTCTT CAGCGTTTTA TTGACCCTCT GGCTAAAGAA 
GAAGAAAATG TTGGCATAGA TATTACTGAA CCTCTATACA TGCAACGACT TGGGGAGATT 
AATGTTATTG GTGAGCCATT TTTAAATGTG AACTGTGAAC ACATCAAATC ATTTGACAAA 
AATTTGTACA GACAACTCAT CTCTTACCCA CAGGAAGTTA TTCCAACTTT TGACATGGCT 
GTCAATGAAA TCTTCTTTGA CCGTTACCCT GACTCAATCT TAGAACATCA GATTCAAGTA 
AGACCATTCA ACGCATTGAA GACTAAGAAT ATGAGAAACC TGAATCCAGA AGACATTGAC 
CAGCTCATCA CCATCAGCGG CATGGTGATC AGGACATCCC AGCTGATTCC CGAGATGCAG 
GAGGCCTTCT TCCAGTGCCA AGTGTGTGCC CACACGACCC GGGTGGAGAT GGACCGCGGC 
CGCATTGCAG AGCCCAGTGT GTGCGGGCGC TGCCACACCA CCCACAGCAT GGCACTCATC 
CACAACCGCT CCCTCTTCTC TGACAAGCAG ATGATCAAGC TTCAGGAGTC TCCGGAAGAC 
ATGCCTGCAG GGCAGACACC ACACACAGTT ATCCTGTTTG CTCACAATGA TCTCGTTGAC 
AAGGTCCAGC CTGGGGACAG AGTGAATGTT ACAGGCATCT ATCGAGCTGT GCCTATTCGA 
GTCAATCCAA GAGTGAGTAA TGTGAAGTCT GTCTACAAAA CCCACATTGA TGTCATTCAT 
TATCGGAAAA CGGATGCAAA ACGTCTGCAT GGCCTTGATG AAGAAGCAGA ACAGAAACTT 
TTTTCAGAGA AACGTGTGGA ATTGCTTAAG GAACTTTCCA GGAAACCAGA CATTTATGAG 
AGGCTTGCTT CAGCCTTGGC TCCAAGCATT TATGAACATG AAGATATAAA GAAGGGAATT 
TTGCTTCAGC TCTTTGGCGG GACAAGGAAG GATTTTAGTC ACACTGGAAG GGGCAAATTT 
CGGGCTGAGA TCAACATCTT GCTGTGTGGC GACCCTGGTA CCAGCAAGTC CCAGCTGCTG 
CAGTACGTGT ACAACCTCGT CCCCAGGGGC CAGTACACGT CTGGGAAGGG CTCCAGTGCA 
GTTGGCCTCA CTGCGTACGT AATGAAAGAC CCTGAGACAA GGCAGCTGGT CCTGCAGACA 
GGTGCTCTTG TCCTGAGTGA CAACGGCATC TGCTGTATCG ATGAGTTCGA CAAGATGAAT 
GAAAGTACAA GATCGGTATT GCATGAAGTC ATGGAACAGC AGACTCTGTC CATTGCAAAG 
GCTGGGATCA TCTGTCAGCT CAATGCGCGC ACCTCTGTCC TGGCAGCAGC AAATCCCATT 
GAGTCTCAGT GGAATCCTAA AAAAACAACC ATTGAAAACA TCCAGCTGCC TCATACTTTA 
TTATCAAGGT TTGATTTGAT CTTCCTCTTG CTGGACCCTC AGGACGAAGC CTATGACAGG 
CGTCTGGCTC ACCACCTGGT CGCACTGTAC TACCAGAGCG AGGAGCAGGC AGAGGAGGAG 
CTCCTGGACA TGGCGGTGCT AAAGGACTAC ATTGCCTACG CGCACAGCAC CATCATGCCG 
CGGCTAAGTG AGGAAGCCAG CCAGGCTCTC ATCGAGGCTT ATGTAGACAT GAGGAAGATT 
GGCAGTAGCC GGGGAATGGT TTCTGCATAC CCTCGACAGC TAGAGTCATT AATCCGCTTA 
GCAGAAGCCC ATGCTAAAGT AAGATTGTCT AACAAAGTTG AAGCCATTGA TGTGGAAGAG 
GCCAAACGCC TCCATCGGGA AGCTCTGAAG CAGTCTGCAA CTGATCCCCG GACTGGCATC 
GTGGACATAT CTATTCTTAC TACGGGGATG AGTGCCACCT CTCGTAAACG GAAAGAAGAA 
TTAGCTGAAG CATTGAAAAA GCTTATTTTA TCTAAGGGCA AAACACCAGC TCTAAAATAC 
CAGCAACTTT TTGAAGATAT TCGGGGACAA TCTGACATAG CAATTACTAA AGATATGTTT 
GAAGAAGCAC TGCGTGCCCT GGCAGATGAT GATTTCCTGA CAGTGACTGG GAAGACCGTG 
CGCTTGCTCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MCM4 ( NM_005914.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_005905.2 Homo sapiens minichromosome maintenance complex component 4 (MCM4), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu11591
Clone ID Related Accession (Same CDS sequence)	NM_005914.3 , NM_005914.4 , NM_182746.3 , NM_182746.2
Accession Version	NM_005914.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2592bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-13
Organism	Homo sapiens(human)
Product	DNA replication licensing factor MCM4
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC021236.10, BC031061.1, BQ689703.1, AK296913.1 and BF793151.1. On Jun 25, 2018 this sequence version replaced NM_005914.3. Transcript Variant: This variant (1) represents a longer transcript and differs in the 5' UTR, as compared to variant 2. Both variants encode the same protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660807.32608.1, SRR1660807.164419.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

ATGTCGTCCC CGGCGTCGAC CCCGAGCCGC CGCGGCAGCC GGCGTGGAAG GGCCACCCCC 
GCCCAGACGC CTCGGAGTGA GGATGCCAGG TCATCTCCCT CTCAGAGACG TAGAGGCGAG 
GATTCCACCT CCACGGGGGA GTTGCAGCCG ATGCCAACCT CGCCTGGAGT GGACCTGCAG 
AGCCCTGCTG CGCAGGACGT GCTGTTTTCC AGCCCTCCCC AAATGCATTC TTCAGCTATC 
CCTCTTGACT TTGATGTTAG TTCACCACTG ACATACGGCA CTCCCAGCTC TCGGGTAGAG 
GGAACCCCAA GAAGTGGTGT TAGGGGCACA CCTGTGAGAC AGAGGCCTGA CCTGGGCTCT 
GCACAGAAGG GCCTGCAAGT GGATCTGCAG TCTGACGGGG CAGCAGCAGA AGATATAGTG 
GCAAGTGAGC AGTCTCTAGG CCAAAAACTT GTGATCTGGG GAACAGATGT AAATGTGGCA 
GCATGCAAAG AAAACTTTCA GAGATTTCTT CAGCGTTTTA TTGACCCTCT GGCTAAAGAA 
GAAGAAAATG TTGGCATAGA TATTACTGAA CCTCTATACA TGCAACGACT TGGGGAGATT 
AATGTTATTG GTGAGCCATT TTTAAATGTG AACTGTGAAC ACATCAAATC ATTTGACAAA 
AATTTGTACA GACAACTCAT CTCTTACCCA CAGGAAGTTA TTCCAACTTT TGACATGGCT 
GTCAATGAAA TCTTCTTTGA CCGTTACCCT GACTCAATCT TAGAACATCA GATTCAAGTA 
AGACCATTCA ACGCATTGAA GACTAAGAAT ATGAGAAACC TGAATCCAGA AGACATTGAC 
CAGCTCATCA CCATCAGCGG CATGGTGATC AGGACATCCC AGCTGATTCC CGAGATGCAG 
GAGGCCTTCT TCCAGTGCCA AGTGTGTGCC CACACGACCC GGGTGGAGAT GGACCGCGGC 
CGCATTGCAG AGCCCAGTGT GTGCGGGCGC TGCCACACCA CCCACAGCAT GGCACTCATC 
CACAACCGCT CCCTCTTCTC TGACAAGCAG ATGATCAAGC TTCAGGAGTC TCCGGAAGAC 
ATGCCTGCAG GGCAGACACC ACACACAGTT ATCCTGTTTG CTCACAATGA TCTCGTTGAC 
AAGGTCCAGC CTGGGGACAG AGTGAATGTT ACAGGCATCT ATCGAGCTGT GCCTATTCGA 
GTCAATCCAA GAGTGAGTAA TGTGAAGTCT GTCTACAAAA CCCACATTGA TGTCATTCAT 
TATCGGAAAA CGGATGCAAA ACGTCTGCAT GGCCTTGATG AAGAAGCAGA ACAGAAACTT 
TTTTCAGAGA AACGTGTGGA ATTGCTTAAG GAACTTTCCA GGAAACCAGA CATTTATGAG 
AGGCTTGCTT CAGCCTTGGC TCCAAGCATT TATGAACATG AAGATATAAA GAAGGGAATT 
TTGCTTCAGC TCTTTGGCGG GACAAGGAAG GATTTTAGTC ACACTGGAAG GGGCAAATTT 
CGGGCTGAGA TCAACATCTT GCTGTGTGGC GACCCTGGTA CCAGCAAGTC CCAGCTGCTG 
CAGTACGTGT ACAACCTCGT CCCCAGGGGC CAGTACACGT CTGGGAAGGG CTCCAGTGCA 
GTTGGCCTCA CTGCGTACGT AATGAAAGAC CCTGAGACAA GGCAGCTGGT CCTGCAGACA 
GGTGCTCTTG TCCTGAGTGA CAACGGCATC TGCTGTATCG ATGAGTTCGA CAAGATGAAT 
GAAAGTACAA GATCGGTATT GCATGAAGTC ATGGAACAGC AGACTCTGTC CATTGCAAAG 
GCTGGGATCA TCTGTCAGCT CAATGCGCGC ACCTCTGTCC TGGCAGCAGC AAATCCCATT 
GAGTCTCAGT GGAATCCTAA AAAAACAACC ATTGAAAACA TCCAGCTGCC TCATACTTTA 
TTATCAAGGT TTGATTTGAT CTTCCTCTTG CTGGACCCTC AGGACGAAGC CTATGACAGG 
CGTCTGGCTC ACCACCTGGT CGCACTGTAC TACCAGAGCG AGGAGCAGGC AGAGGAGGAG 
CTCCTGGACA TGGCGGTGCT AAAGGACTAC ATTGCCTACG CGCACAGCAC CATCATGCCG 
CGGCTAAGTG AGGAAGCCAG CCAGGCTCTC ATCGAGGCTT ATGTAGACAT GAGGAAGATT 
GGCAGTAGCC GGGGAATGGT TTCTGCATAC CCTCGACAGC TAGAGTCATT AATCCGCTTA 
GCAGAAGCCC ATGCTAAAGT AAGATTGTCT AACAAAGTTG AAGCCATTGA TGTGGAAGAG 
GCCAAACGCC TCCATCGGGA AGCTCTGAAG CAGTCTGCAA CTGATCCCCG GACTGGCATC 
GTGGACATAT CTATTCTTAC TACGGGGATG AGTGCCACCT CTCGTAAACG GAAAGAAGAA 
TTAGCTGAAG CATTGAAAAA GCTTATTTTA TCTAAGGGCA AAACACCAGC TCTAAAATAC 
CAGCAACTTT TTGAAGATAT TCGGGGACAA TCTGACATAG CAATTACTAA AGATATGTTT 
GAAGAAGCAC TGCGTGCCCT GGCAGATGAT GATTTCCTGA CAGTGACTGG GAAGACCGTG 
CGCTTGCTCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005905.2
CDS	205..2796
Translation	MSSPASTPSRRGSRRGRATPAQTPRSEDARSSPSQRRRGEDSTSTGELQPMPTSPGVDLQSPAAQDVLFSSPPQMHSSAIPLDFDVSSPLTYGTPSSRVEGTPRSGVRGTPVRQRPDLGSAQKGLQVDLQSDGAAAEDIVASEQSLGQKLVIWGTDVNVAACKENFQRFLQRFIDPLAKEEENVGIDITEPLYMQRLGEINVIGEPFLNVNCEHIKSFDKNLYRQLISYPQEVIPTFDMAVNEIFFDRYPDSILEHQIQVRPFNALKTKNMRNLNPEDIDQLITISGMVIRTSQLIPEMQEAFFQCQVCAHTTRVEMDRGRIAEPSVCGRCHTTHSMALIHNRSLFSDKQMIKLQESPEDMPAGQTPHTVILFAHNDLVDKVQPGDRVNVTGIYRAVPIRVNPRVSNVKSVYKTHIDVIHYRKTDAKRLHGLDEEAEQKLFSEKRVELLKELSRKPDIYERLASALAPSIYEHEDIKKGILLQLFGGTRKDFSHTGRGKFRAEINILLCGDPGTSKSQLLQYVYNLVPRGQYTSGKGSSAVGLTAYVMKDPETRQLVLQTGALVLSDNGICCIDEFDKMNESTRSVLHEVMEQQTLSIAKAGIICQLNARTSVLAAANPIESQWNPKKTTIENIQLPHTLLSRFDLIFLLLDPQDEAYDRRLAHHLVALYYQSEEQAEEELLDMAVLKDYIAYAHSTIMPRLSEEASQALIEAYVDMRKIGSSRGMVSAYPRQLESLIRLAEAHAKVRLSNKVEAIDVEEAKRLHREALKQSATDPRTGIVDISILTTGMSATSRKRKEELAEALKKLILSKGKTPALKYQQLFEDIRGQSDIAITKDMFEEALRALADDDFLTVTGKTVRLL

Target ORF information:

RefSeq Version	NM_005914.4
Organism	Homo sapiens(human)
Definition	Homo sapiens minichromosome maintenance complex component 4 (MCM4), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005914.4

ORF Insert Sequence:

ATGTCGTCCC CGGCGTCGAC CCCGAGCCGC CGCGGCAGCC GGCGTGGAAG GGCCACCCCC 
GCCCAGACGC CTCGGAGTGA GGATGCCAGG TCATCTCCCT CTCAGAGACG TAGAGGCGAG 
GATTCCACCT CCACGGGGGA GTTGCAGCCG ATGCCAACCT CGCCTGGAGT GGACCTGCAG 
AGCCCTGCTG CGCAGGACGT GCTGTTTTCC AGCCCTCCCC AAATGCATTC TTCAGCTATC 
CCTCTTGACT TTGATGTTAG TTCACCACTG ACATACGGCA CTCCCAGCTC TCGGGTAGAG 
GGAACCCCAA GAAGTGGTGT TAGGGGCACA CCTGTGAGAC AGAGGCCTGA CCTGGGCTCT 
GCACAGAAGG GCCTGCAAGT GGATCTGCAG TCTGACGGGG CAGCAGCAGA AGATATAGTG 
GCAAGTGAGC AGTCTCTAGG CCAAAAACTT GTGATCTGGG GAACAGATGT AAATGTGGCA 
GCATGCAAAG AAAACTTTCA GAGATTTCTT CAGCGTTTTA TTGACCCTCT GGCTAAAGAA 
GAAGAAAATG TTGGCATAGA TATTACTGAA CCTCTATACA TGCAACGACT TGGGGAGATT 
AATGTTATTG GTGAGCCATT TTTAAATGTG AACTGTGAAC ACATCAAATC ATTTGACAAA 
AATTTGTACA GACAACTCAT CTCTTACCCA CAGGAAGTTA TTCCAACTTT TGACATGGCT 
GTCAATGAAA TCTTCTTTGA CCGTTACCCT GACTCAATCT TAGAACATCA GATTCAAGTA 
AGACCATTCA ACGCATTGAA GACTAAGAAT ATGAGAAACC TGAATCCAGA AGACATTGAC 
CAGCTCATCA CCATCAGCGG CATGGTGATC AGGACATCCC AGCTGATTCC CGAGATGCAG 
GAGGCCTTCT TCCAGTGCCA AGTGTGTGCC CACACGACCC GGGTGGAGAT GGACCGCGGC 
CGCATTGCAG AGCCCAGTGT GTGCGGGCGC TGCCACACCA CCCACAGCAT GGCACTCATC 
CACAACCGCT CCCTCTTCTC TGACAAGCAG ATGATCAAGC TTCAGGAGTC TCCGGAAGAC 
ATGCCTGCAG GGCAGACACC ACACACAGTT ATCCTGTTTG CTCACAATGA TCTCGTTGAC 
AAGGTCCAGC CTGGGGACAG AGTGAATGTT ACAGGCATCT ATCGAGCTGT GCCTATTCGA 
GTCAATCCAA GAGTGAGTAA TGTGAAGTCT GTCTACAAAA CCCACATTGA TGTCATTCAT 
TATCGGAAAA CGGATGCAAA ACGTCTGCAT GGCCTTGATG AAGAAGCAGA ACAGAAACTT 
TTTTCAGAGA AACGTGTGGA ATTGCTTAAG GAACTTTCCA GGAAACCAGA CATTTATGAG 
AGGCTTGCTT CAGCCTTGGC TCCAAGCATT TATGAACATG AAGATATAAA GAAGGGAATT 
TTGCTTCAGC TCTTTGGCGG GACAAGGAAG GATTTTAGTC ACACTGGAAG GGGCAAATTT 
CGGGCTGAGA TCAACATCTT GCTGTGTGGC GACCCTGGTA CCAGCAAGTC CCAGCTGCTG 
CAGTACGTGT ACAACCTCGT CCCCAGGGGC CAGTACACGT CTGGGAAGGG CTCCAGTGCA 
GTTGGCCTCA CTGCGTACGT AATGAAAGAC CCTGAGACAA GGCAGCTGGT CCTGCAGACA 
GGTGCTCTTG TCCTGAGTGA CAACGGCATC TGCTGTATCG ATGAGTTCGA CAAGATGAAT 
GAAAGTACAA GATCGGTATT GCATGAAGTC ATGGAACAGC AGACTCTGTC CATTGCAAAG 
GCTGGGATCA TCTGTCAGCT CAATGCGCGC ACCTCTGTCC TGGCAGCAGC AAATCCCATT 
GAGTCTCAGT GGAATCCTAA AAAAACAACC ATTGAAAACA TCCAGCTGCC TCATACTTTA 
TTATCAAGGT TTGATTTGAT CTTCCTCTTG CTGGACCCTC AGGACGAAGC CTATGACAGG 
CGTCTGGCTC ACCACCTGGT CGCACTGTAC TACCAGAGCG AGGAGCAGGC AGAGGAGGAG 
CTCCTGGACA TGGCGGTGCT AAAGGACTAC ATTGCCTACG CGCACAGCAC CATCATGCCG 
CGGCTAAGTG AGGAAGCCAG CCAGGCTCTC ATCGAGGCTT ATGTAGACAT GAGGAAGATT 
GGCAGTAGCC GGGGAATGGT TTCTGCATAC CCTCGACAGC TAGAGTCATT AATCCGCTTA 
GCAGAAGCCC ATGCTAAAGT AAGATTGTCT AACAAAGTTG AAGCCATTGA TGTGGAAGAG 
GCCAAACGCC TCCATCGGGA AGCTCTGAAG CAGTCTGCAA CTGATCCCCG GACTGGCATC 
GTGGACATAT CTATTCTTAC TACGGGGATG AGTGCCACCT CTCGTAAACG GAAAGAAGAA 
TTAGCTGAAG CATTGAAAAA GCTTATTTTA TCTAAGGGCA AAACACCAGC TCTAAAATAC 
CAGCAACTTT TTGAAGATAT TCGGGGACAA TCTGACATAG CAATTACTAA AGATATGTTT 
GAAGAAGCAC TGCGTGCCCT GGCAGATGAT GATTTCCTGA CAGTGACTGG GAAGACCGTG 
CGCTTGCTCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MCM4 ( NM_182746.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_877423.1 Homo sapiens minichromosome maintenance complex component 4 (MCM4), transcript variant 2, mRNA.

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CloneID	OHu11591
Clone ID Related Accession (Same CDS sequence)	NM_005914.3 , NM_005914.4 , NM_182746.3 , NM_182746.2
Accession Version	NM_182746.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2592bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-13
Organism	Homo sapiens(human)
Product	DNA replication licensing factor MCM4
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC021236.10, AK022899.1, BC031061.1 and BQ689703.1. This sequence is a reference standard in the RefSeqGene project. On Jun 25, 2018 this sequence version replaced NM_182746.2. Transcript Variant: This variant (2) lacks a segment in the 5' UTR, when compared to variant 1. Both variants encode the same protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803611.250739.1, SRR1803616.36926.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000649973.1/ ENSP00000496964.1 RefSeq Select criteria :: based on manual assertion, conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGTCGTCCC CGGCGTCGAC CCCGAGCCGC CGCGGCAGCC GGCGTGGAAG GGCCACCCCC 
GCCCAGACGC CTCGGAGTGA GGATGCCAGG TCATCTCCCT CTCAGAGACG TAGAGGCGAG 
GATTCCACCT CCACGGGGGA GTTGCAGCCG ATGCCAACCT CGCCTGGAGT GGACCTGCAG 
AGCCCTGCTG CGCAGGACGT GCTGTTTTCC AGCCCTCCCC AAATGCATTC TTCAGCTATC 
CCTCTTGACT TTGATGTTAG TTCACCACTG ACATACGGCA CTCCCAGCTC TCGGGTAGAG 
GGAACCCCAA GAAGTGGTGT TAGGGGCACA CCTGTGAGAC AGAGGCCTGA CCTGGGCTCT 
GCACAGAAGG GCCTGCAAGT GGATCTGCAG TCTGACGGGG CAGCAGCAGA AGATATAGTG 
GCAAGTGAGC AGTCTCTAGG CCAAAAACTT GTGATCTGGG GAACAGATGT AAATGTGGCA 
GCATGCAAAG AAAACTTTCA GAGATTTCTT CAGCGTTTTA TTGACCCTCT GGCTAAAGAA 
GAAGAAAATG TTGGCATAGA TATTACTGAA CCTCTATACA TGCAACGACT TGGGGAGATT 
AATGTTATTG GTGAGCCATT TTTAAATGTG AACTGTGAAC ACATCAAATC ATTTGACAAA 
AATTTGTACA GACAACTCAT CTCTTACCCA CAGGAAGTTA TTCCAACTTT TGACATGGCT 
GTCAATGAAA TCTTCTTTGA CCGTTACCCT GACTCAATCT TAGAACATCA GATTCAAGTA 
AGACCATTCA ACGCATTGAA GACTAAGAAT ATGAGAAACC TGAATCCAGA AGACATTGAC 
CAGCTCATCA CCATCAGCGG CATGGTGATC AGGACATCCC AGCTGATTCC CGAGATGCAG 
GAGGCCTTCT TCCAGTGCCA AGTGTGTGCC CACACGACCC GGGTGGAGAT GGACCGCGGC 
CGCATTGCAG AGCCCAGTGT GTGCGGGCGC TGCCACACCA CCCACAGCAT GGCACTCATC 
CACAACCGCT CCCTCTTCTC TGACAAGCAG ATGATCAAGC TTCAGGAGTC TCCGGAAGAC 
ATGCCTGCAG GGCAGACACC ACACACAGTT ATCCTGTTTG CTCACAATGA TCTCGTTGAC 
AAGGTCCAGC CTGGGGACAG AGTGAATGTT ACAGGCATCT ATCGAGCTGT GCCTATTCGA 
GTCAATCCAA GAGTGAGTAA TGTGAAGTCT GTCTACAAAA CCCACATTGA TGTCATTCAT 
TATCGGAAAA CGGATGCAAA ACGTCTGCAT GGCCTTGATG AAGAAGCAGA ACAGAAACTT 
TTTTCAGAGA AACGTGTGGA ATTGCTTAAG GAACTTTCCA GGAAACCAGA CATTTATGAG 
AGGCTTGCTT CAGCCTTGGC TCCAAGCATT TATGAACATG AAGATATAAA GAAGGGAATT 
TTGCTTCAGC TCTTTGGCGG GACAAGGAAG GATTTTAGTC ACACTGGAAG GGGCAAATTT 
CGGGCTGAGA TCAACATCTT GCTGTGTGGC GACCCTGGTA CCAGCAAGTC CCAGCTGCTG 
CAGTACGTGT ACAACCTCGT CCCCAGGGGC CAGTACACGT CTGGGAAGGG CTCCAGTGCA 
GTTGGCCTCA CTGCGTACGT AATGAAAGAC CCTGAGACAA GGCAGCTGGT CCTGCAGACA 
GGTGCTCTTG TCCTGAGTGA CAACGGCATC TGCTGTATCG ATGAGTTCGA CAAGATGAAT 
GAAAGTACAA GATCGGTATT GCATGAAGTC ATGGAACAGC AGACTCTGTC CATTGCAAAG 
GCTGGGATCA TCTGTCAGCT CAATGCGCGC ACCTCTGTCC TGGCAGCAGC AAATCCCATT 
GAGTCTCAGT GGAATCCTAA AAAAACAACC ATTGAAAACA TCCAGCTGCC TCATACTTTA 
TTATCAAGGT TTGATTTGAT CTTCCTCTTG CTGGACCCTC AGGACGAAGC CTATGACAGG 
CGTCTGGCTC ACCACCTGGT CGCACTGTAC TACCAGAGCG AGGAGCAGGC AGAGGAGGAG 
CTCCTGGACA TGGCGGTGCT AAAGGACTAC ATTGCCTACG CGCACAGCAC CATCATGCCG 
CGGCTAAGTG AGGAAGCCAG CCAGGCTCTC ATCGAGGCTT ATGTAGACAT GAGGAAGATT 
GGCAGTAGCC GGGGAATGGT TTCTGCATAC CCTCGACAGC TAGAGTCATT AATCCGCTTA 
GCAGAAGCCC ATGCTAAAGT AAGATTGTCT AACAAAGTTG AAGCCATTGA TGTGGAAGAG 
GCCAAACGCC TCCATCGGGA AGCTCTGAAG CAGTCTGCAA CTGATCCCCG GACTGGCATC 
GTGGACATAT CTATTCTTAC TACGGGGATG AGTGCCACCT CTCGTAAACG GAAAGAAGAA 
TTAGCTGAAG CATTGAAAAA GCTTATTTTA TCTAAGGGCA AAACACCAGC TCTAAAATAC 
CAGCAACTTT TTGAAGATAT TCGGGGACAA TCTGACATAG CAATTACTAA AGATATGTTT 
GAAGAAGCAC TGCGTGCCCT GGCAGATGAT GATTTCCTGA CAGTGACTGG GAAGACCGTG 
CGCTTGCTCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_877423.1
CDS	89..2680
Translation	MSSPASTPSRRGSRRGRATPAQTPRSEDARSSPSQRRRGEDSTSTGELQPMPTSPGVDLQSPAAQDVLFSSPPQMHSSAIPLDFDVSSPLTYGTPSSRVEGTPRSGVRGTPVRQRPDLGSAQKGLQVDLQSDGAAAEDIVASEQSLGQKLVIWGTDVNVAACKENFQRFLQRFIDPLAKEEENVGIDITEPLYMQRLGEINVIGEPFLNVNCEHIKSFDKNLYRQLISYPQEVIPTFDMAVNEIFFDRYPDSILEHQIQVRPFNALKTKNMRNLNPEDIDQLITISGMVIRTSQLIPEMQEAFFQCQVCAHTTRVEMDRGRIAEPSVCGRCHTTHSMALIHNRSLFSDKQMIKLQESPEDMPAGQTPHTVILFAHNDLVDKVQPGDRVNVTGIYRAVPIRVNPRVSNVKSVYKTHIDVIHYRKTDAKRLHGLDEEAEQKLFSEKRVELLKELSRKPDIYERLASALAPSIYEHEDIKKGILLQLFGGTRKDFSHTGRGKFRAEINILLCGDPGTSKSQLLQYVYNLVPRGQYTSGKGSSAVGLTAYVMKDPETRQLVLQTGALVLSDNGICCIDEFDKMNESTRSVLHEVMEQQTLSIAKAGIICQLNARTSVLAAANPIESQWNPKKTTIENIQLPHTLLSRFDLIFLLLDPQDEAYDRRLAHHLVALYYQSEEQAEEELLDMAVLKDYIAYAHSTIMPRLSEEASQALIEAYVDMRKIGSSRGMVSAYPRQLESLIRLAEAHAKVRLSNKVEAIDVEEAKRLHREALKQSATDPRTGIVDISILTTGMSATSRKRKEELAEALKKLILSKGKTPALKYQQLFEDIRGQSDIAITKDMFEEALRALADDDFLTVTGKTVRLL

Target ORF information:

RefSeq Version	NM_182746.3
Organism	Homo sapiens(human)
Definition	Homo sapiens minichromosome maintenance complex component 4 (MCM4), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_182746.3

ORF Insert Sequence:

ATGTCGTCCC CGGCGTCGAC CCCGAGCCGC CGCGGCAGCC GGCGTGGAAG GGCCACCCCC 
GCCCAGACGC CTCGGAGTGA GGATGCCAGG TCATCTCCCT CTCAGAGACG TAGAGGCGAG 
GATTCCACCT CCACGGGGGA GTTGCAGCCG ATGCCAACCT CGCCTGGAGT GGACCTGCAG 
AGCCCTGCTG CGCAGGACGT GCTGTTTTCC AGCCCTCCCC AAATGCATTC TTCAGCTATC 
CCTCTTGACT TTGATGTTAG TTCACCACTG ACATACGGCA CTCCCAGCTC TCGGGTAGAG 
GGAACCCCAA GAAGTGGTGT TAGGGGCACA CCTGTGAGAC AGAGGCCTGA CCTGGGCTCT 
GCACAGAAGG GCCTGCAAGT GGATCTGCAG TCTGACGGGG CAGCAGCAGA AGATATAGTG 
GCAAGTGAGC AGTCTCTAGG CCAAAAACTT GTGATCTGGG GAACAGATGT AAATGTGGCA 
GCATGCAAAG AAAACTTTCA GAGATTTCTT CAGCGTTTTA TTGACCCTCT GGCTAAAGAA 
GAAGAAAATG TTGGCATAGA TATTACTGAA CCTCTATACA TGCAACGACT TGGGGAGATT 
AATGTTATTG GTGAGCCATT TTTAAATGTG AACTGTGAAC ACATCAAATC ATTTGACAAA 
AATTTGTACA GACAACTCAT CTCTTACCCA CAGGAAGTTA TTCCAACTTT TGACATGGCT 
GTCAATGAAA TCTTCTTTGA CCGTTACCCT GACTCAATCT TAGAACATCA GATTCAAGTA 
AGACCATTCA ACGCATTGAA GACTAAGAAT ATGAGAAACC TGAATCCAGA AGACATTGAC 
CAGCTCATCA CCATCAGCGG CATGGTGATC AGGACATCCC AGCTGATTCC CGAGATGCAG 
GAGGCCTTCT TCCAGTGCCA AGTGTGTGCC CACACGACCC GGGTGGAGAT GGACCGCGGC 
CGCATTGCAG AGCCCAGTGT GTGCGGGCGC TGCCACACCA CCCACAGCAT GGCACTCATC 
CACAACCGCT CCCTCTTCTC TGACAAGCAG ATGATCAAGC TTCAGGAGTC TCCGGAAGAC 
ATGCCTGCAG GGCAGACACC ACACACAGTT ATCCTGTTTG CTCACAATGA TCTCGTTGAC 
AAGGTCCAGC CTGGGGACAG AGTGAATGTT ACAGGCATCT ATCGAGCTGT GCCTATTCGA 
GTCAATCCAA GAGTGAGTAA TGTGAAGTCT GTCTACAAAA CCCACATTGA TGTCATTCAT 
TATCGGAAAA CGGATGCAAA ACGTCTGCAT GGCCTTGATG AAGAAGCAGA ACAGAAACTT 
TTTTCAGAGA AACGTGTGGA ATTGCTTAAG GAACTTTCCA GGAAACCAGA CATTTATGAG 
AGGCTTGCTT CAGCCTTGGC TCCAAGCATT TATGAACATG AAGATATAAA GAAGGGAATT 
TTGCTTCAGC TCTTTGGCGG GACAAGGAAG GATTTTAGTC ACACTGGAAG GGGCAAATTT 
CGGGCTGAGA TCAACATCTT GCTGTGTGGC GACCCTGGTA CCAGCAAGTC CCAGCTGCTG 
CAGTACGTGT ACAACCTCGT CCCCAGGGGC CAGTACACGT CTGGGAAGGG CTCCAGTGCA 
GTTGGCCTCA CTGCGTACGT AATGAAAGAC CCTGAGACAA GGCAGCTGGT CCTGCAGACA 
GGTGCTCTTG TCCTGAGTGA CAACGGCATC TGCTGTATCG ATGAGTTCGA CAAGATGAAT 
GAAAGTACAA GATCGGTATT GCATGAAGTC ATGGAACAGC AGACTCTGTC CATTGCAAAG 
GCTGGGATCA TCTGTCAGCT CAATGCGCGC ACCTCTGTCC TGGCAGCAGC AAATCCCATT 
GAGTCTCAGT GGAATCCTAA AAAAACAACC ATTGAAAACA TCCAGCTGCC TCATACTTTA 
TTATCAAGGT TTGATTTGAT CTTCCTCTTG CTGGACCCTC AGGACGAAGC CTATGACAGG 
CGTCTGGCTC ACCACCTGGT CGCACTGTAC TACCAGAGCG AGGAGCAGGC AGAGGAGGAG 
CTCCTGGACA TGGCGGTGCT AAAGGACTAC ATTGCCTACG CGCACAGCAC CATCATGCCG 
CGGCTAAGTG AGGAAGCCAG CCAGGCTCTC ATCGAGGCTT ATGTAGACAT GAGGAAGATT 
GGCAGTAGCC GGGGAATGGT TTCTGCATAC CCTCGACAGC TAGAGTCATT AATCCGCTTA 
GCAGAAGCCC ATGCTAAAGT AAGATTGTCT AACAAAGTTG AAGCCATTGA TGTGGAAGAG 
GCCAAACGCC TCCATCGGGA AGCTCTGAAG CAGTCTGCAA CTGATCCCCG GACTGGCATC 
GTGGACATAT CTATTCTTAC TACGGGGATG AGTGCCACCT CTCGTAAACG GAAAGAAGAA 
TTAGCTGAAG CATTGAAAAA GCTTATTTTA TCTAAGGGCA AAACACCAGC TCTAAAATAC 
CAGCAACTTT TTGAAGATAT TCGGGGACAA TCTGACATAG CAATTACTAA AGATATGTTT 
GAAGAAGCAC TGCGTGCCCT GGCAGATGAT GATTTCCTGA CAGTGACTGG GAAGACCGTG 
CGCTTGCTCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MCM4 ( NM_182746.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_877423.1 Homo sapiens minichromosome maintenance complex component 4 (MCM4), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu11591
Clone ID Related Accession (Same CDS sequence)	NM_005914.3 , NM_005914.4 , NM_182746.3 , NM_182746.2
Accession Version	NM_182746.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2592bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	DNA replication licensing factor MCM4
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC021236.10, AK022899.1, BC031061.1 and BQ689703.1. On Mar 10, 2011 this sequence version replaced NM_182746.1. Transcript Variant: This variant (2) lacks a segment in the 5' UTR, when compared to variant 1. Both variants encode the same protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803614.277481.1, SRR1803616.36926.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

ATGTCGTCCC CGGCGTCGAC CCCGAGCCGC CGCGGCAGCC GGCGTGGAAG GGCCACCCCC 
GCCCAGACGC CTCGGAGTGA GGATGCCAGG TCATCTCCCT CTCAGAGACG TAGAGGCGAG 
GATTCCACCT CCACGGGGGA GTTGCAGCCG ATGCCAACCT CGCCTGGAGT GGACCTGCAG 
AGCCCTGCTG CGCAGGACGT GCTGTTTTCC AGCCCTCCCC AAATGCATTC TTCAGCTATC 
CCTCTTGACT TTGATGTTAG TTCACCACTG ACATACGGCA CTCCCAGCTC TCGGGTAGAG 
GGAACCCCAA GAAGTGGTGT TAGGGGCACA CCTGTGAGAC AGAGGCCTGA CCTGGGCTCT 
GCACAGAAGG GCCTGCAAGT GGATCTGCAG TCTGACGGGG CAGCAGCAGA AGATATAGTG 
GCAAGTGAGC AGTCTCTAGG CCAAAAACTT GTGATCTGGG GAACAGATGT AAATGTGGCA 
GCATGCAAAG AAAACTTTCA GAGATTTCTT CAGCGTTTTA TTGACCCTCT GGCTAAAGAA 
GAAGAAAATG TTGGCATAGA TATTACTGAA CCTCTATACA TGCAACGACT TGGGGAGATT 
AATGTTATTG GTGAGCCATT TTTAAATGTG AACTGTGAAC ACATCAAATC ATTTGACAAA 
AATTTGTACA GACAACTCAT CTCTTACCCA CAGGAAGTTA TTCCAACTTT TGACATGGCT 
GTCAATGAAA TCTTCTTTGA CCGTTACCCT GACTCAATCT TAGAACATCA GATTCAAGTA 
AGACCATTCA ACGCATTGAA GACTAAGAAT ATGAGAAACC TGAATCCAGA AGACATTGAC 
CAGCTCATCA CCATCAGCGG CATGGTGATC AGGACATCCC AGCTGATTCC CGAGATGCAG 
GAGGCCTTCT TCCAGTGCCA AGTGTGTGCC CACACGACCC GGGTGGAGAT GGACCGCGGC 
CGCATTGCAG AGCCCAGTGT GTGCGGGCGC TGCCACACCA CCCACAGCAT GGCACTCATC 
CACAACCGCT CCCTCTTCTC TGACAAGCAG ATGATCAAGC TTCAGGAGTC TCCGGAAGAC 
ATGCCTGCAG GGCAGACACC ACACACAGTT ATCCTGTTTG CTCACAATGA TCTCGTTGAC 
AAGGTCCAGC CTGGGGACAG AGTGAATGTT ACAGGCATCT ATCGAGCTGT GCCTATTCGA 
GTCAATCCAA GAGTGAGTAA TGTGAAGTCT GTCTACAAAA CCCACATTGA TGTCATTCAT 
TATCGGAAAA CGGATGCAAA ACGTCTGCAT GGCCTTGATG AAGAAGCAGA ACAGAAACTT 
TTTTCAGAGA AACGTGTGGA ATTGCTTAAG GAACTTTCCA GGAAACCAGA CATTTATGAG 
AGGCTTGCTT CAGCCTTGGC TCCAAGCATT TATGAACATG AAGATATAAA GAAGGGAATT 
TTGCTTCAGC TCTTTGGCGG GACAAGGAAG GATTTTAGTC ACACTGGAAG GGGCAAATTT 
CGGGCTGAGA TCAACATCTT GCTGTGTGGC GACCCTGGTA CCAGCAAGTC CCAGCTGCTG 
CAGTACGTGT ACAACCTCGT CCCCAGGGGC CAGTACACGT CTGGGAAGGG CTCCAGTGCA 
GTTGGCCTCA CTGCGTACGT AATGAAAGAC CCTGAGACAA GGCAGCTGGT CCTGCAGACA 
GGTGCTCTTG TCCTGAGTGA CAACGGCATC TGCTGTATCG ATGAGTTCGA CAAGATGAAT 
GAAAGTACAA GATCGGTATT GCATGAAGTC ATGGAACAGC AGACTCTGTC CATTGCAAAG 
GCTGGGATCA TCTGTCAGCT CAATGCGCGC ACCTCTGTCC TGGCAGCAGC AAATCCCATT 
GAGTCTCAGT GGAATCCTAA AAAAACAACC ATTGAAAACA TCCAGCTGCC TCATACTTTA 
TTATCAAGGT TTGATTTGAT CTTCCTCTTG CTGGACCCTC AGGACGAAGC CTATGACAGG 
CGTCTGGCTC ACCACCTGGT CGCACTGTAC TACCAGAGCG AGGAGCAGGC AGAGGAGGAG 
CTCCTGGACA TGGCGGTGCT AAAGGACTAC ATTGCCTACG CGCACAGCAC CATCATGCCG 
CGGCTAAGTG AGGAAGCCAG CCAGGCTCTC ATCGAGGCTT ATGTAGACAT GAGGAAGATT 
GGCAGTAGCC GGGGAATGGT TTCTGCATAC CCTCGACAGC TAGAGTCATT AATCCGCTTA 
GCAGAAGCCC ATGCTAAAGT AAGATTGTCT AACAAAGTTG AAGCCATTGA TGTGGAAGAG 
GCCAAACGCC TCCATCGGGA AGCTCTGAAG CAGTCTGCAA CTGATCCCCG GACTGGCATC 
GTGGACATAT CTATTCTTAC TACGGGGATG AGTGCCACCT CTCGTAAACG GAAAGAAGAA 
TTAGCTGAAG CATTGAAAAA GCTTATTTTA TCTAAGGGCA AAACACCAGC TCTAAAATAC 
CAGCAACTTT TTGAAGATAT TCGGGGACAA TCTGACATAG CAATTACTAA AGATATGTTT 
GAAGAAGCAC TGCGTGCCCT GGCAGATGAT GATTTCCTGA CAGTGACTGG GAAGACCGTG 
CGCTTGCTCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_877423.1
CDS	827..3418
Translation	MSSPASTPSRRGSRRGRATPAQTPRSEDARSSPSQRRRGEDSTSTGELQPMPTSPGVDLQSPAAQDVLFSSPPQMHSSAIPLDFDVSSPLTYGTPSSRVEGTPRSGVRGTPVRQRPDLGSAQKGLQVDLQSDGAAAEDIVASEQSLGQKLVIWGTDVNVAACKENFQRFLQRFIDPLAKEEENVGIDITEPLYMQRLGEINVIGEPFLNVNCEHIKSFDKNLYRQLISYPQEVIPTFDMAVNEIFFDRYPDSILEHQIQVRPFNALKTKNMRNLNPEDIDQLITISGMVIRTSQLIPEMQEAFFQCQVCAHTTRVEMDRGRIAEPSVCGRCHTTHSMALIHNRSLFSDKQMIKLQESPEDMPAGQTPHTVILFAHNDLVDKVQPGDRVNVTGIYRAVPIRVNPRVSNVKSVYKTHIDVIHYRKTDAKRLHGLDEEAEQKLFSEKRVELLKELSRKPDIYERLASALAPSIYEHEDIKKGILLQLFGGTRKDFSHTGRGKFRAEINILLCGDPGTSKSQLLQYVYNLVPRGQYTSGKGSSAVGLTAYVMKDPETRQLVLQTGALVLSDNGICCIDEFDKMNESTRSVLHEVMEQQTLSIAKAGIICQLNARTSVLAAANPIESQWNPKKTTIENIQLPHTLLSRFDLIFLLLDPQDEAYDRRLAHHLVALYYQSEEQAEEELLDMAVLKDYIAYAHSTIMPRLSEEASQALIEAYVDMRKIGSSRGMVSAYPRQLESLIRLAEAHAKVRLSNKVEAIDVEEAKRLHREALKQSATDPRTGIVDISILTTGMSATSRKRKEELAEALKKLILSKGKTPALKYQQLFEDIRGQSDIAITKDMFEEALRALADDDFLTVTGKTVRLL

Target ORF information:

RefSeq Version	NM_182746.2
Organism	Homo sapiens(human)
Definition	Homo sapiens minichromosome maintenance complex component 4 (MCM4), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_182746.2

ORF Insert Sequence:

ATGTCGTCCC CGGCGTCGAC CCCGAGCCGC CGCGGCAGCC GGCGTGGAAG GGCCACCCCC 
GCCCAGACGC CTCGGAGTGA GGATGCCAGG TCATCTCCCT CTCAGAGACG TAGAGGCGAG 
GATTCCACCT CCACGGGGGA GTTGCAGCCG ATGCCAACCT CGCCTGGAGT GGACCTGCAG 
AGCCCTGCTG CGCAGGACGT GCTGTTTTCC AGCCCTCCCC AAATGCATTC TTCAGCTATC 
CCTCTTGACT TTGATGTTAG TTCACCACTG ACATACGGCA CTCCCAGCTC TCGGGTAGAG 
GGAACCCCAA GAAGTGGTGT TAGGGGCACA CCTGTGAGAC AGAGGCCTGA CCTGGGCTCT 
GCACAGAAGG GCCTGCAAGT GGATCTGCAG TCTGACGGGG CAGCAGCAGA AGATATAGTG 
GCAAGTGAGC AGTCTCTAGG CCAAAAACTT GTGATCTGGG GAACAGATGT AAATGTGGCA 
GCATGCAAAG AAAACTTTCA GAGATTTCTT CAGCGTTTTA TTGACCCTCT GGCTAAAGAA 
GAAGAAAATG TTGGCATAGA TATTACTGAA CCTCTATACA TGCAACGACT TGGGGAGATT 
AATGTTATTG GTGAGCCATT TTTAAATGTG AACTGTGAAC ACATCAAATC ATTTGACAAA 
AATTTGTACA GACAACTCAT CTCTTACCCA CAGGAAGTTA TTCCAACTTT TGACATGGCT 
GTCAATGAAA TCTTCTTTGA CCGTTACCCT GACTCAATCT TAGAACATCA GATTCAAGTA 
AGACCATTCA ACGCATTGAA GACTAAGAAT ATGAGAAACC TGAATCCAGA AGACATTGAC 
CAGCTCATCA CCATCAGCGG CATGGTGATC AGGACATCCC AGCTGATTCC CGAGATGCAG 
GAGGCCTTCT TCCAGTGCCA AGTGTGTGCC CACACGACCC GGGTGGAGAT GGACCGCGGC 
CGCATTGCAG AGCCCAGTGT GTGCGGGCGC TGCCACACCA CCCACAGCAT GGCACTCATC 
CACAACCGCT CCCTCTTCTC TGACAAGCAG ATGATCAAGC TTCAGGAGTC TCCGGAAGAC 
ATGCCTGCAG GGCAGACACC ACACACAGTT ATCCTGTTTG CTCACAATGA TCTCGTTGAC 
AAGGTCCAGC CTGGGGACAG AGTGAATGTT ACAGGCATCT ATCGAGCTGT GCCTATTCGA 
GTCAATCCAA GAGTGAGTAA TGTGAAGTCT GTCTACAAAA CCCACATTGA TGTCATTCAT 
TATCGGAAAA CGGATGCAAA ACGTCTGCAT GGCCTTGATG AAGAAGCAGA ACAGAAACTT 
TTTTCAGAGA AACGTGTGGA ATTGCTTAAG GAACTTTCCA GGAAACCAGA CATTTATGAG 
AGGCTTGCTT CAGCCTTGGC TCCAAGCATT TATGAACATG AAGATATAAA GAAGGGAATT 
TTGCTTCAGC TCTTTGGCGG GACAAGGAAG GATTTTAGTC ACACTGGAAG GGGCAAATTT 
CGGGCTGAGA TCAACATCTT GCTGTGTGGC GACCCTGGTA CCAGCAAGTC CCAGCTGCTG 
CAGTACGTGT ACAACCTCGT CCCCAGGGGC CAGTACACGT CTGGGAAGGG CTCCAGTGCA 
GTTGGCCTCA CTGCGTACGT AATGAAAGAC CCTGAGACAA GGCAGCTGGT CCTGCAGACA 
GGTGCTCTTG TCCTGAGTGA CAACGGCATC TGCTGTATCG ATGAGTTCGA CAAGATGAAT 
GAAAGTACAA GATCGGTATT GCATGAAGTC ATGGAACAGC AGACTCTGTC CATTGCAAAG 
GCTGGGATCA TCTGTCAGCT CAATGCGCGC ACCTCTGTCC TGGCAGCAGC AAATCCCATT 
GAGTCTCAGT GGAATCCTAA AAAAACAACC ATTGAAAACA TCCAGCTGCC TCATACTTTA 
TTATCAAGGT TTGATTTGAT CTTCCTCTTG CTGGACCCTC AGGACGAAGC CTATGACAGG 
CGTCTGGCTC ACCACCTGGT CGCACTGTAC TACCAGAGCG AGGAGCAGGC AGAGGAGGAG 
CTCCTGGACA TGGCGGTGCT AAAGGACTAC ATTGCCTACG CGCACAGCAC CATCATGCCG 
CGGCTAAGTG AGGAAGCCAG CCAGGCTCTC ATCGAGGCTT ATGTAGACAT GAGGAAGATT 
GGCAGTAGCC GGGGAATGGT TTCTGCATAC CCTCGACAGC TAGAGTCATT AATCCGCTTA 
GCAGAAGCCC ATGCTAAAGT AAGATTGTCT AACAAAGTTG AAGCCATTGA TGTGGAAGAG 
GCCAAACGCC TCCATCGGGA AGCTCTGAAG CAGTCTGCAA CTGATCCCCG GACTGGCATC 
GTGGACATAT CTATTCTTAC TACGGGGATG AGTGCCACCT CTCGTAAACG GAAAGAAGAA 
TTAGCTGAAG CATTGAAAAA GCTTATTTTA TCTAAGGGCA AAACACCAGC TCTAAAATAC 
CAGCAACTTT TTGAAGATAT TCGGGGACAA TCTGACATAG CAATTACTAA AGATATGTTT 
GAAGAAGCAC TGCGTGCCCT GGCAGATGAT GATTTCCTGA CAGTGACTGG GAAGACCGTG 
CGCTTGCTCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Minichromosome maintenance (MCM) protein 4 overexpression is a potential prognostic marker for laryngeal squamous cell carcinoma.
Journal of B.U.ON. : official journal of the Balkan Union of Oncology22(5)1272-1277(2017 Sep-Oct)
Han J,Lian M,Fang J,Liu H,Wang R,Zhai J,Fan Yang Y,Fen L,Shi Q,Zhi Ma H,Sun J,Ma Z

Architecture of the human interactome defines protein communities and disease networks.
Nature545(7655)505-509(2017 05)
Huttlin EL,Bruckner RJ,Paulo JA,Cannon JR,Ting L,Baltier K,Colby G,Gebreab F,Gygi MP,Parzen H,Szpyt J,Tam S,Zarraga G,Pontano-Vaites L,Swarup S,White AE,Schweppe DK,Rad R,Erickson BK,Obar RA,Guruharsha KG,Li K,Artavanis-Tsakonas S,Gygi SP,Harper JW

An MCM4 mutation detected in cancer cells affects MCM4/6/7 complex formation.
Journal of biochemistry161(3)259-268(2017 Mar)
Tatsumi R,Ishimi Y

MCM4 and MCM7, potential novel proliferation markers, significantly correlated with Ki-67, Bmi1, and cyclin E expression in esophageal adenocarcinoma, squamous cell carcinoma, and precancerous lesions.
Human pathology57126-135(2016 11)
Choy B,LaLonde A,Que J,Wu T,Zhou Z

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MCM4 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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