MC5R cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	MC5R
Entrez Gene ID	4161
Full Name	melanocortin 5 receptor
Synonyms	MC2
General protein information	Preferred Names melanocortin 5 receptor Names melanocortin receptor 5
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 18 Map Location: 18p11.21
Summary	This gene encodes a member of the seven-pass transmembrane G protein-coupled melanocortin receptor protein family that stimulate cAMP signal transduction. The encoded protein is a receptor for melanocyte-stimulating hormone and adrenocorticotropic hormone and is suggested to play a role in sebum generation. [provided by RefSeq, Jun 2010].
Disorder MIM:	600042

mRNA and Protein(s)

mRNA	Protein	Name
NM_005913.2	NP_005904.1	melanocortin receptor 5
NM_005913.3	NP_005904.1	melanocortin receptor 5

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	MC5R	XP_005615457.1
Mus musculus (house mouse)	Mc5r	NP_038624.2
Pan troglodytes (chimpanzee)	MC5R	NP_001009119.1
Bos taurus (cattle)	MC5R	NP_001015542.1
Rattus norvegicus (Norway rat)	Mc5r	NP_037314.1
Gallus gallus (chicken)	MC5R	NP_001026186.1
Danio rerio (zebrafish)	mc5ra	NP_775386.1
Xenopus tropicalis (tropical clawed frog)	mc5r	NP_001096392.1
Homo sapiens (human)	MC5R	NP_005904.1
	MC5R	XP_001090783.1

Gene Ontology
Bibliography

Related articles in PubMed

Cell surface targeting of the Melanocortin 5 Receptor (MC5R) requires serine-rich terminal motifs.
Rodrigues AR, Sousa D, Almeida H, Gouveia AM
Biochimica et biophysica acta1864(7)1217-1226(2017 07)

Expression of melanocortin receptors in human endometrium.
Lantang AM, Innes BA, Gan EH, Pearce SH, Lash GE
Human reproduction (Oxford, England)30(10)2404-10(2015 Oct)

Melanocortins contribute to sequential differentiation and enucleation of human erythroblasts via melanocortin receptors 1, 2 and 5.
Simamura E, Arikawa T, Ikeda T, Shimada H, Shoji H, Masuta H, Nakajima Y, Otani H, Yonekura H, Hatta T
PloS one10(4)e0123232(2015)

Molecular characterization of human melanocortin-5 receptor ligand-receptor interaction.
Yang Y, Mishra VK, Chen M, Duffee E, Dimmitt R, Harmon CM
Biochemistry52(10)1737-45(2013 Mar)

Glutamine235 and arginine272 in human melanocortin 5 receptor determines its low affinity to MSH.
Fr?ndberg PA, Xu X, Chhajlani V
Biochemical and biophysical research communications236(2)489-92(1997 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Mutations in residues S4/S5 and S17/E18 retained MC5R at the ER/Golgi complex and did not affect MC5R homodimerization.
Title: Cell surface targeting of the Melanocortin 5 Receptor (MC5R) requires serine-rich terminal motifs.

melanocortin receptors MC2R, MC3R and MC5R are most abundantly expressed in glandular epithelium of the endometrium
Title: Expression of melanocortin receptors in human endometrium.

MC2R and MC1R signals are consecutively required for the regulation of EPO signal transduction in erythroblast differentiation, and MC5R signal transduction is required to induce enucleation.
Title: Melanocortins contribute to sequential differentiation and enucleation of human erythroblasts via melanocortin receptors 1, 2 and 5.

D115 and D119 in TM3, F195 in TM5, and F254 in TM6 may form a binding pocket for NDP-alpha-MSH binding.
Title: Molecular characterization of human melanocortin-5 receptor ligand-receptor interaction.

Melanocortin 5 receptor signaling and internalization: role of MAPK/ERK pathway and beta-arrestins 1/2.
Title: Melanocortin 5 receptor signaling and internalization: role of MAPK/ERK pathway and ?-arrestins 1/2.

The following MC5R gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MC5R cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu11730	NM_005913.3 Latest version!	Homo sapiens melanocortin 5 receptor (MC5R), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$216.30 $309.00
View Old Accession Versions >>
OHu11730	NM_005913.2	Homo sapiens melanocortin 5 receptor (MC5R), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$216.30 $309.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

MC5R ( NM_005913.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_005904.1 Homo sapiens melanocortin 5 receptor (MC5R), mRNA.

Price & Availability↑

CloneID	OHu11730
Clone ID Related Accession (Same CDS sequence)	NM_005913.2 , NM_005913.3
Accession Version	NM_005913.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 978bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-21
Organism	Homo sapiens(human)
Product	melanocortin receptor 5
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC095531.1 and AP001525.6. On Jun 9, 2010 this sequence version replaced NM_005913.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: BC095531.1 [ECO:0000345] ##Evidence-Data-END##

ATGAATTCCT CATTTCACCT GCATTTCTTG GATCTCAACC TGAATGCCAC AGAGGGCAAC 
CTTTCAGGAC CCAATGTCAA AAACAAGTCT TCACCATGTG AAGACATGGG CATTGCTGTG 
GAGGTGTTTC TCACTCTGGG TGTCATCAGC CTCTTGGAGA ACATCTTGGT CATAGGGGCC 
ATAGTGAAGA ACAAAAACCT GCACTCCCCC ATGTACTTCT TCGTGTGCAG CCTGGCAGTG 
GCGGACATGC TGGTGAGCAT GTCCAGTGCC TGGGAGACCA TCACCATCTA CCTACTCAAC 
AACAAGCACC TAGTGATAGC AGACGCCTTT GTGCGCCACA TTGACAATGT GTTTGACTCC 
ATGATCTGCA TTTCCGTGGT GGCATCCATG TGCAGCTTAC TGGCCATTGC AGTGGATAGG 
TACGTCACCA TCTTCTACGC CCTGCGCTAC CACCACATCA TGACGGCGAG GCGCTCAGGG 
GCCATCATCG CCGGCATCTG GGCTTTCTGC ACGGGCTGCG GCATTGTCTT CATCCTGTAC 
TCAGAATCCA CCTACGTCAT CCTGTGCCTC ATCTCCATGT TCTTCGCTAT GCTGTTCCTC 
CTGGTGTCTC TGTACATACA CATGTTCCTC CTGGCGCGGA CTCACGTCAA GCGGATCGCG 
GCTCTGCCCG GGGCCAGCTC TGCGCGGCAG AGGACCAGCA TGCAGGGCGC GGTCACCGTC 
ACCATGCTGC TGGGCGTGTT TACCGTGTGC TGGGCCCCGT TCTTCCTTCA TCTCACTTTA 
ATGCTTTCTT GCCCTCAGAA CCTCTACTGC TCTCGCTTCA TGTCTCACTT CAATATGTAC 
CTCATACTCA TCATGTGTAA TTCCGTGATG GACCCTCTCA TATATGCCTT CCGCAGCCAA 
GAGATGCGGA AGACCTTTAA GGAGATTATT TGCTGCCGTG GTTTCAGGAT CGCCTGCAGC 
TTTCCCAGAA GGGATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005904.1
CDS	223..1200
Translation	MNSSFHLHFLDLNLNATEGNLSGPNVKNKSSPCEDMGIAVEVFLTLGVISLLENILVIGAIVKNKNLHSPMYFFVCSLAVADMLVSMSSAWETITIYLLNNKHLVIADAFVRHIDNVFDSMICISVVASMCSLLAIAVDRYVTIFYALRYHHIMTARRSGAIIAGIWAFCTGCGIVFILYSESTYVILCLISMFFAMLFLLVSLYIHMFLLARTHVKRIAALPGASSARQRTSMQGAVTVTMLLGVFTVCWAPFFLHLTLMLSCPQNLYCSRFMSHFNMYLILIMCNSVMDPLIYAFRSQEMRKTFKEIICCRGFRIACSFPRRD

Target ORF information:

RefSeq Version	NM_005913.2
Organism	Homo sapiens(human)
Definition	Homo sapiens melanocortin 5 receptor (MC5R), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005913.2

ORF Insert Sequence:

ATGAATTCCT CATTTCACCT GCATTTCTTG GATCTCAACC TGAATGCCAC AGAGGGCAAC 
CTTTCAGGAC CCAATGTCAA AAACAAGTCT TCACCATGTG AAGACATGGG CATTGCTGTG 
GAGGTGTTTC TCACTCTGGG TGTCATCAGC CTCTTGGAGA ACATCTTGGT CATAGGGGCC 
ATAGTGAAGA ACAAAAACCT GCACTCCCCC ATGTACTTCT TCGTGTGCAG CCTGGCAGTG 
GCGGACATGC TGGTGAGCAT GTCCAGTGCC TGGGAGACCA TCACCATCTA CCTACTCAAC 
AACAAGCACC TAGTGATAGC AGACGCCTTT GTGCGCCACA TTGACAATGT GTTTGACTCC 
ATGATCTGCA TTTCCGTGGT GGCATCCATG TGCAGCTTAC TGGCCATTGC AGTGGATAGG 
TACGTCACCA TCTTCTACGC CCTGCGCTAC CACCACATCA TGACGGCGAG GCGCTCAGGG 
GCCATCATCG CCGGCATCTG GGCTTTCTGC ACGGGCTGCG GCATTGTCTT CATCCTGTAC 
TCAGAATCCA CCTACGTCAT CCTGTGCCTC ATCTCCATGT TCTTCGCTAT GCTGTTCCTC 
CTGGTGTCTC TGTACATACA CATGTTCCTC CTGGCGCGGA CTCACGTCAA GCGGATCGCG 
GCTCTGCCCG GGGCCAGCTC TGCGCGGCAG AGGACCAGCA TGCAGGGCGC GGTCACCGTC 
ACCATGCTGC TGGGCGTGTT TACCGTGTGC TGGGCCCCGT TCTTCCTTCA TCTCACTTTA 
ATGCTTTCTT GCCCTCAGAA CCTCTACTGC TCTCGCTTCA TGTCTCACTT CAATATGTAC 
CTCATACTCA TCATGTGTAA TTCCGTGATG GACCCTCTCA TATATGCCTT CCGCAGCCAA 
GAGATGCGGA AGACCTTTAA GGAGATTATT TGCTGCCGTG GTTTCAGGAT CGCCTGCAGC 
TTTCCCAGAA GGGATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MC5R ( NM_005913.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_005904.1 Homo sapiens melanocortin 5 receptor (MC5R), mRNA.

Price & Availability↑

CloneID	OHu11730
Clone ID Related Accession (Same CDS sequence)	NM_005913.2 , NM_005913.3
Accession Version	NM_005913.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 978bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-21
Organism	Homo sapiens(human)
Product	melanocortin receptor 5
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AP001525.6, DR002771.1 and BC069153.1. On May 30, 2019 this sequence version replaced NM_005913.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803616.65151.1, DR002771.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2157437, SAMEA2158800 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000589410.2/ ENSP00000468086.2 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGAATTCCT CATTTCACCT GCATTTCTTG GATCTCAACC TGAATGCCAC AGAGGGCAAC 
CTTTCAGGAC CCAATGTCAA AAACAAGTCT TCACCATGTG AAGACATGGG CATTGCTGTG 
GAGGTGTTTC TCACTCTGGG TGTCATCAGC CTCTTGGAGA ACATCTTGGT CATAGGGGCC 
ATAGTGAAGA ACAAAAACCT GCACTCCCCC ATGTACTTCT TCGTGTGCAG CCTGGCAGTG 
GCGGACATGC TGGTGAGCAT GTCCAGTGCC TGGGAGACCA TCACCATCTA CCTACTCAAC 
AACAAGCACC TAGTGATAGC AGACGCCTTT GTGCGCCACA TTGACAATGT GTTTGACTCC 
ATGATCTGCA TTTCCGTGGT GGCATCCATG TGCAGCTTAC TGGCCATTGC AGTGGATAGG 
TACGTCACCA TCTTCTACGC CCTGCGCTAC CACCACATCA TGACGGCGAG GCGCTCAGGG 
GCCATCATCG CCGGCATCTG GGCTTTCTGC ACGGGCTGCG GCATTGTCTT CATCCTGTAC 
TCAGAATCCA CCTACGTCAT CCTGTGCCTC ATCTCCATGT TCTTCGCTAT GCTGTTCCTC 
CTGGTGTCTC TGTACATACA CATGTTCCTC CTGGCGCGGA CTCACGTCAA GCGGATCGCG 
GCTCTGCCCG GGGCCAGCTC TGCGCGGCAG AGGACCAGCA TGCAGGGCGC GGTCACCGTC 
ACCATGCTGC TGGGCGTGTT TACCGTGTGC TGGGCCCCGT TCTTCCTTCA TCTCACTTTA 
ATGCTTTCTT GCCCTCAGAA CCTCTACTGC TCTCGCTTCA TGTCTCACTT CAATATGTAC 
CTCATACTCA TCATGTGTAA TTCCGTGATG GACCCTCTCA TATATGCCTT CCGCAGCCAA 
GAGATGCGGA AGACCTTTAA GGAGATTATT TGCTGCCGTG GTTTCAGGAT CGCCTGCAGC 
TTTCCCAGAA GGGATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005904.1
CDS	166..1143
Translation	MNSSFHLHFLDLNLNATEGNLSGPNVKNKSSPCEDMGIAVEVFLTLGVISLLENILVIGAIVKNKNLHSPMYFFVCSLAVADMLVSMSSAWETITIYLLNNKHLVIADAFVRHIDNVFDSMICISVVASMCSLLAIAVDRYVTIFYALRYHHIMTARRSGAIIAGIWAFCTGCGIVFILYSESTYVILCLISMFFAMLFLLVSLYIHMFLLARTHVKRIAALPGASSARQRTSMQGAVTVTMLLGVFTVCWAPFFLHLTLMLSCPQNLYCSRFMSHFNMYLILIMCNSVMDPLIYAFRSQEMRKTFKEIICCRGFRIACSFPRRD

Target ORF information:

RefSeq Version	NM_005913.3
Organism	Homo sapiens(human)
Definition	Homo sapiens melanocortin 5 receptor (MC5R), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005913.3

ORF Insert Sequence:

ATGAATTCCT CATTTCACCT GCATTTCTTG GATCTCAACC TGAATGCCAC AGAGGGCAAC 
CTTTCAGGAC CCAATGTCAA AAACAAGTCT TCACCATGTG AAGACATGGG CATTGCTGTG 
GAGGTGTTTC TCACTCTGGG TGTCATCAGC CTCTTGGAGA ACATCTTGGT CATAGGGGCC 
ATAGTGAAGA ACAAAAACCT GCACTCCCCC ATGTACTTCT TCGTGTGCAG CCTGGCAGTG 
GCGGACATGC TGGTGAGCAT GTCCAGTGCC TGGGAGACCA TCACCATCTA CCTACTCAAC 
AACAAGCACC TAGTGATAGC AGACGCCTTT GTGCGCCACA TTGACAATGT GTTTGACTCC 
ATGATCTGCA TTTCCGTGGT GGCATCCATG TGCAGCTTAC TGGCCATTGC AGTGGATAGG 
TACGTCACCA TCTTCTACGC CCTGCGCTAC CACCACATCA TGACGGCGAG GCGCTCAGGG 
GCCATCATCG CCGGCATCTG GGCTTTCTGC ACGGGCTGCG GCATTGTCTT CATCCTGTAC 
TCAGAATCCA CCTACGTCAT CCTGTGCCTC ATCTCCATGT TCTTCGCTAT GCTGTTCCTC 
CTGGTGTCTC TGTACATACA CATGTTCCTC CTGGCGCGGA CTCACGTCAA GCGGATCGCG 
GCTCTGCCCG GGGCCAGCTC TGCGCGGCAG AGGACCAGCA TGCAGGGCGC GGTCACCGTC 
ACCATGCTGC TGGGCGTGTT TACCGTGTGC TGGGCCCCGT TCTTCCTTCA TCTCACTTTA 
ATGCTTTCTT GCCCTCAGAA CCTCTACTGC TCTCGCTTCA TGTCTCACTT CAATATGTAC 
CTCATACTCA TCATGTGTAA TTCCGTGATG GACCCTCTCA TATATGCCTT CCGCAGCCAA 
GAGATGCGGA AGACCTTTAA GGAGATTATT TGCTGCCGTG GTTTCAGGAT CGCCTGCAGC 
TTTCCCAGAA GGGATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Cell surface targeting of the Melanocortin 5 Receptor (MC5R) requires serine-rich terminal motifs.
Biochimica et biophysica acta1864(7)1217-1226(2017 07)
Rodrigues AR,Sousa D,Almeida H,Gouveia AM

Expression of melanocortin receptors in human endometrium.
Human reproduction (Oxford, England)30(10)2404-10(2015 Oct)
Lantang AM,Innes BA,Gan EH,Pearce SH,Lash GE

Melanocortins contribute to sequential differentiation and enucleation of human erythroblasts via melanocortin receptors 1, 2 and 5.
PloS one10(4)e0123232(2015)
Simamura E,Arikawa T,Ikeda T,Shimada H,Shoji H,Masuta H,Nakajima Y,Otani H,Yonekura H,Hatta T

Molecular characterization of human melanocortin-5 receptor ligand-receptor interaction.
Biochemistry52(10)1737-45(2013 Mar)
Yang Y,Mishra VK,Chen M,Duffee E,Dimmitt R,Harmon CM

Glutamine235 and arginine272 in human melanocortin 5 receptor determines its low affinity to MSH.
Biochemical and biophysical research communications236(2)489-92(1997 Jul)
Fr?ndberg PA,Xu X,Chhajlani V

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MC5R cDNA ORF clone, Homo sapiens(human)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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