MC3R cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	MC3R
Entrez Gene ID	4159
Full Name	melanocortin 3 receptor
Synonyms	BMIQ9,MC3,MC3-R,OB20,OQTL
General protein information	Preferred Names melanocortin 3 receptor Names melanocortin receptor 3 obesity quantitative trait locus
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 20 Map Location: 20q13.2
Summary	This gene encodes a G-protein-coupled receptor for melanocyte-stimulating hormone and adrenocorticotropic hormone that is expressed in tissues other than the adrenal cortex and melanocytes. This gene maps to the same region as the locus for benign neonatal epilepsy. Mice deficient for this gene have increased fat mass despite decreased food intake, suggesting a role for this gene product in the regulation of energy homeostasis. Mutations in this gene are associated with a susceptibility to obesity in humans. [provided by RefSeq, Jul 2008].
Disorder MIM:	155540
Disorder Html:	{Obesity, severe, susceptibility to, BMIQ9}, 602025 (3); {Mycobacterium tuberculosis, protection against}, 607948 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_019888.3	NP_063941.3	melanocortin receptor 3

Pathways from BioSystems

Homologies

Homo sapiens (human)	MC3R	NP_063941.3
Pan troglodytes (chimpanzee)	MC3R	XP_525362.1
Mus musculus (house mouse)	Mc3r	NP_032587.1
Rattus norvegicus (Norway rat)	Mc3r	NP_001020441.3
Gallus gallus (chicken)	LOC100857164	XP_004947293.1
Danio rerio (zebrafish)	mc3r	NP_851303.1
Xenopus tropicalis (tropical clawed frog)	mc3r	XP_002935436.1
Canis lupus familiaris (dog)	MC3R	NP_001128596.1
	LOC698439	XP_001091108.1
Bos taurus (cattle)	MC3R	XP_002692472.1

Gene Ontology
Bibliography

Related articles in PubMed

Structural Insights into Selective Ligand-Receptor Interactions Leading to Receptor Inactivation Utilizing Selective Melanocortin 3 Receptor Antagonists.
Cai M, Marelli UK, Mertz B, Beck JG, Opperer F, Rechenmacher F, Kessler H, Hruby VJ
Biochemistry56(32)4201-4209(2017 08)

Functional characterization of melanocortin-3 receptor variants identify a loss-of-function mutation involving an amino acid critical for G protein-coupled receptor activation.
Tao YX, Segaloff DL
The Journal of clinical endocrinology and metabolism89(8)3936-42(2004 Aug)

Deletions of the N-terminal regions of the human melanocortin receptors.
Schi?th HB, Petersson S, Muceniece R, Szardenings M, Wikberg JE
FEBS letters410(2-3)223-8(1997 Jun)

Molecular cloning of a novel melanocortin receptor.
Gantz I, Konda Y, Tashiro T, Shimoto Y, Miwa H, Munzert G, Watson SJ, DelValle J, Yamada T
The Journal of biological chemistry268(11)8246-50(1993 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Structural Insights into Selective Ligand-Receptor Interactions Leading to Receptor Inactivation Utilizing Selective Melanocortin 3 Receptor Antagonists.
Title: Structural Insights into Selective Ligand-Receptor Interactions Leading to Receptor Inactivation Utilizing Selective Melanocortin 3 Receptor Antagonists.

Results show regulation of melanocortin receptors MC2R, MC3R and MC4R gene expressions in CD8(+) cytotoxic T-lymphocytes and CD19(+) B lymphocytes in rheumatoid arthritis (RA) treated with tumor necrosis factor-alpha (TNF-alpha) inhibitor adalimumab.
Title: Melanocortin 2, 3 and 4 Receptor Gene Expressions are Downregulated in CD8

Replacing murine Mc3r with and double-mutant (C17A+G241A) human MC3R showed greater weight and fat mass, increased energy intake and feeding efficiency.
Title: A mouse model for a partially inactive obesity-associated human MC3R variant.

MC3R mutations are associated with Obesity.
Title: Mutations in Melanocortin-3 Receptor Gene and Human Obesity.

There is no evidence of any association between MC3R variations and obesity.
Title: Genetic variant screening of MC3R and MC4R genes in early-onset obese children and their relatives among a Thai population: family-based study.

The following MC3R gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MC3R cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu17783	NM_019888.3 Latest version!	Homo sapiens melanocortin 3 receptor (MC3R), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

MC3R ( NM_019888.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_063941.3 Homo sapiens melanocortin 3 receptor (MC3R), mRNA.

Price & Availability↑

CloneID	OHu17783
Clone ID Related Accession (Same CDS sequence)	NM_019888.3
Accession Version	NM_019888.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 972bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Homo sapiens(human)
Product	melanocortin receptor 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC069105.1. This sequence is a reference standard in the RefSeqGene project. On Mar 22, 2008 this sequence version replaced NM_019888.2. Sequence Note: A downstream start codon is selected for this RefSeq based on conservation with homologs and for consistency with other family members, including the human melanocortin 4 and melanocortin 5 receptors. The use of an alternative upstream start codon, which is specific to primate species, would increase the protein length from 323 aa to 360 aa. This longer protein is referred to in the literature, including PMIDs 15292330 and 8463333. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: BC069105.1, BC069599.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: lack of evidence for use of upstream AUG MANE Ensembl match :: ENST00000243911.2/ ENSP00000243911.2 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGAATGCTT CGTGCTGCCT GCCCTCTGTT CAGCCAACAC TGCCTAATGG CTCGGAGCAC 
CTCCAAGCCC CTTTCTTCAG CAACCAGAGC AGCAGCGCCT TCTGTGAGCA GGTCTTCATC 
AAGCCCGAGG TTTTCCTGTC TCTGGGCATC GTCAGTCTGC TGGAAAACAT CCTGGTTATC 
CTGGCCGTGG TCAGGAACGG CAACCTGCAC TCCCCGATGT ACTTCTTTCT CTGCAGCCTG 
GCGGTGGCCG ACATGCTGGT AAGTGTGTCC AATGCCCTGG AGACCATCAT GATCGCCATC 
GTCCACAGCG ACTACCTGAC CTTCGAGGAC CAGTTTATCC AGCACATGGA CAACATCTTC 
GACTCCATGA TCTGCATCTC CCTGGTGGCC TCCATCTGCA ACCTCCTGGC CATCGCCGTC 
GACAGGTACG TCACCATCTT TTACGCGCTC CGCTACCACA GCATCATGAC CGTGAGGAAG 
GCCCTCACCT TGATCGTGGC CATCTGGGTC TGCTGCGGCG TCTGTGGCGT GGTGTTCATC 
GTCTACTCGG AGAGCAAAAT GGTCATTGTG TGCCTCATCA CCATGTTCTT CGCCATGATG 
CTCCTCATGG GCACCCTCTA CGTGCACATG TTCCTCTTTG CGCGGCTGCA CGTCAAGCGC 
ATAGCAGCAC TGCCACCTGC CGACGGGGTG GCCCCACAGC AACACTCATG CATGAAGGGG 
GCAGTCACCA TCACCATTCT CCTGGGCGTG TTCATCTTCT GCTGGGCCCC CTTCTTCCTC 
CACCTGGTCC TCATCATCAC CTGCCCCACC AACCCCTACT GCATCTGCTA CACTGCCCAC 
TTCAACACCT ACCTGGTCCT CATCATGTGC AACTCCGTCA TCGACCCACT CATCTACGCT 
TTCCGGAGCC TGGAATTGCG CAACACCTTT AGGGAGATTC TCTGTGGCTG CAACGGCATG 
AACTTGGGAT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_063941.3
CDS	113..1084
Translation	MNASCCLPSVQPTLPNGSEHLQAPFFSNQSSSAFCEQVFIKPEVFLSLGIVSLLENILVILAVVRNGNLHSPMYFFLCSLAVADMLVSVSNALETIMIAIVHSDYLTFEDQFIQHMDNIFDSMICISLVASICNLLAIAVDRYVTIFYALRYHSIMTVRKALTLIVAIWVCCGVCGVVFIVYSESKMVIVCLITMFFAMMLLMGTLYVHMFLFARLHVKRIAALPPADGVAPQQHSCMKGAVTITILLGVFIFCWAPFFLHLVLIITCPTNPYCICYTAHFNTYLVLIMCNSVIDPLIYAFRSLELRNTFREILCGCNGMNLG

Target ORF information:

RefSeq Version	NM_019888.3
Organism	Homo sapiens(human)
Definition	Homo sapiens melanocortin 3 receptor (MC3R), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_019888.3

ORF Insert Sequence:

ATGAATGCTT CGTGCTGCCT GCCCTCTGTT CAGCCAACAC TGCCTAATGG CTCGGAGCAC 
CTCCAAGCCC CTTTCTTCAG CAACCAGAGC AGCAGCGCCT TCTGTGAGCA GGTCTTCATC 
AAGCCCGAGG TTTTCCTGTC TCTGGGCATC GTCAGTCTGC TGGAAAACAT CCTGGTTATC 
CTGGCCGTGG TCAGGAACGG CAACCTGCAC TCCCCGATGT ACTTCTTTCT CTGCAGCCTG 
GCGGTGGCCG ACATGCTGGT AAGTGTGTCC AATGCCCTGG AGACCATCAT GATCGCCATC 
GTCCACAGCG ACTACCTGAC CTTCGAGGAC CAGTTTATCC AGCACATGGA CAACATCTTC 
GACTCCATGA TCTGCATCTC CCTGGTGGCC TCCATCTGCA ACCTCCTGGC CATCGCCGTC 
GACAGGTACG TCACCATCTT TTACGCGCTC CGCTACCACA GCATCATGAC CGTGAGGAAG 
GCCCTCACCT TGATCGTGGC CATCTGGGTC TGCTGCGGCG TCTGTGGCGT GGTGTTCATC 
GTCTACTCGG AGAGCAAAAT GGTCATTGTG TGCCTCATCA CCATGTTCTT CGCCATGATG 
CTCCTCATGG GCACCCTCTA CGTGCACATG TTCCTCTTTG CGCGGCTGCA CGTCAAGCGC 
ATAGCAGCAC TGCCACCTGC CGACGGGGTG GCCCCACAGC AACACTCATG CATGAAGGGG 
GCAGTCACCA TCACCATTCT CCTGGGCGTG TTCATCTTCT GCTGGGCCCC CTTCTTCCTC 
CACCTGGTCC TCATCATCAC CTGCCCCACC AACCCCTACT GCATCTGCTA CACTGCCCAC 
TTCAACACCT ACCTGGTCCT CATCATGTGC AACTCCGTCA TCGACCCACT CATCTACGCT 
TTCCGGAGCC TGGAATTGCG CAACACCTTT AGGGAGATTC TCTGTGGCTG CAACGGCATG 
AACTTGGGAT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Structural Insights into Selective Ligand-Receptor Interactions Leading to Receptor Inactivation Utilizing Selective Melanocortin 3 Receptor Antagonists.
Biochemistry56(32)4201-4209(2017 08)
Cai M,Marelli UK,Mertz B,Beck JG,Opperer F,Rechenmacher F,Kessler H,Hruby VJ

Functional characterization of melanocortin-3 receptor variants identify a loss-of-function mutation involving an amino acid critical for G protein-coupled receptor activation.
The Journal of clinical endocrinology and metabolism89(8)3936-42(2004 Aug)
Tao YX,Segaloff DL

Deletions of the N-terminal regions of the human melanocortin receptors.
FEBS letters410(2-3)223-8(1997 Jun)
Schi?th HB,Petersson S,Muceniece R,Szardenings M,Wikberg JE

Molecular cloning of a novel melanocortin receptor.
The Journal of biological chemistry268(11)8246-50(1993 Apr)
Gantz I,Konda Y,Tashiro T,Shimoto Y,Miwa H,Munzert G,Watson SJ,DelValle J,Yamada T

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MC3R cDNA ORF clone, Homo sapiens(human)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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