BLID cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	BLID
Entrez Gene ID	414899
Full Name	BH3-like motif containing, cell death inducer
Synonyms	BRCC2
General protein information	Preferred Names BH3-like motif containing, cell death inducer Names BH3-like motif-containing cell death inducer breast cancer cell 2 breast cancer cell protein 2
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 11 Map Location: 11q24.1
Summary	This gene encodes a BH3-like motif containing protein involved in cell death. The encoded protein may induce apoptosis in a caspase-dependent manner. The protein is localized in both the cytoplasm and the mitochondrion. [provided by RefSeq, Aug 2011].
Disorder MIM:	608853

mRNA and Protein(s)

mRNA	Protein	Name
NM_001001786.2	NP_001001786.2	BH3-like motif-containing cell death inducer
NM_001001786.3	NP_001001786.2	BH3-like motif-containing cell death inducer

Pathways from BioSystems

Homologies

Homo sapiens (human)	BLID	NP_001001786.2
Pan troglodytes (chimpanzee)	BLID	XP_003952112.1

Gene Ontology
Bibliography

Related articles in PubMed

MicroRNA-575 targets BLID to promote growth and invasion of non-small cell lung cancer cells.
Wang H, Yan C, Shi X, Zheng J, Deng L, Yang L, Yu F, Yang Y, Shao Y
FEBS letters589(7)805-11(2015 Mar)

Aberrant BLID expression is associated with breast cancer progression.
Li X, Su P, Liu X, Kong X, Zhang X, Zhang H, Yang Q
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine35(6)5449-52(2014 Jun)

BLID: A Novel Tumor-Suppressor Gene.
Yu X, Li Z
Oncology research22(5-6)333-8(2014)

BRCC2 inhibits breast cancer cell growth and metastasis in vitro and in vivo via downregulating AKT pathway.
Li X, Kong X, Wang Y, Yang Q
Cell death & disease4e757(2013 Aug)

Frequent loss of the BLID gene in early-onset breast cancer.
Cavalli LR, Noone AM, Makambi KH, Rone JD, Kasid UN, Haddad BR
Cytogenetic and genome research135(1)19-24(2011)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Results showed that the expression of BLID is frequently downregulated in non-small cell lung tumors and cell lines and inversely correlates with miR-575 expression.
Title: MicroRNA-575 targets BLID to promote growth and invasion of non-small cell lung cancer cells.

loss of BLID may contribute to the progression of intraductal proliferation lesions to breast cancer.
Title: Aberrant BLID expression is associated with breast cancer progression.

BRCC2 functions as a novel tumor suppressor in breast cancer and may be a potential therapeutic target for breast cancer management.
Title: BRCC2 inhibits breast cancer cell growth and metastasis in vitro and in vivo via downregulating AKT pathway.

Frequent loss of the BLID gene is observed in early-onset breast cancer.
Title: Frequent loss of the BLID gene in early-onset breast cancer.

Tag single nucleotide polymorphisms near the BLID and LOC399959 genes are not susceptibility loci for high myopia in the Chinese Han population.
Title: Evaluation of BLID and LOC399959 as candidate genes for high myopia in the Chinese Han population.

The following BLID gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the BLID cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu31540	NM_001001786.3 Latest version!	Homo sapiens BH3-like motif containing, cell death inducer (BLID), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu31540	NM_001001786.2	Homo sapiens BH3-like motif containing, cell death inducer (BLID), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

BLID ( NM_001001786.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001001786.2 Homo sapiens BH3-like motif containing, cell death inducer (BLID), mRNA.

Price & Availability↑

CloneID	OHu31540
Clone ID Related Accession (Same CDS sequence)	NM_001001786.2 , NM_001001786.3
Accession Version	NM_001001786.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 327bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-06-23
Organism	Homo sapiens(human)
Product	BH3-like motif-containing cell death inducer
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF303179.1 and BC130363.1. On Jan 24, 2009 this sequence version replaced NM_001001786.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: AF303179.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: PMID: 15069058 ##RefSeq-Attributes-END##

ATGGTGACTT TGTTGCCTAT AGAGGGCCAG GAAATACATT TCTTTGAGAT CCTAGAATCT 
GAGTGTGTGC TCTACACAGG ATGGATAGAG CGAGCCTCTG GCAGTTCCAT TTATCCAGAG 
GCAAAAGCAC GCCTGCCACT GGAGGCGCTC TTGGGTTCCA ACAAAGAACC TATGTTGCCT 
AAGGAAACAG TGCTTTCTCT TAAAAGGTAC AATCTTGGCT CCTCTGCCAT GAAGCGGAAT 
GTTCCTGGAC ATGTGCTTCA GAGACCTTCC TATTTAACCA GGATACAAGT TACATTGTTA 
TGCAATTCCT CTGCTGAGGC CCTGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001001786.2
CDS	294..620
Translation	MVTLLPIEGQEIHFFEILESECVLYTGWIERASGSSIYPEAKARLPLEALLGSNKEPMLPKETVLSLKRYNLGSSAMKRNVPGHVLQRPSYLTRIQVTLLCNSSAEAL

Target ORF information:

RefSeq Version	NM_001001786.2
Organism	Homo sapiens(human)
Definition	Homo sapiens BH3-like motif containing, cell death inducer (BLID), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001001786.2

ORF Insert Sequence:

ATGGTGACTT TGTTGCCTAT AGAGGGCCAG GAAATACATT TCTTTGAGAT CCTAGAATCT 
GAGTGTGTGC TCTACACAGG ATGGATAGAG CGAGCCTCTG GCAGTTCCAT TTATCCAGAG 
GCAAAAGCAC GCCTGCCACT GGAGGCGCTC TTGGGTTCCA ACAAAGAACC TATGTTGCCT 
AAGGAAACAG TGCTTTCTCT TAAAAGGTAC AATCTTGGCT CCTCTGCCAT GAAGCGGAAT 
GTTCCTGGAC ATGTGCTTCA GAGACCTTCC TATTTAACCA GGATACAAGT TACATTGTTA 
TGCAATTCCT CTGCTGAGGC CCTGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

BLID ( NM_001001786.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001001786.2 Homo sapiens BH3-like motif containing, cell death inducer (BLID), mRNA.

Price & Availability↑

CloneID	OHu31540
Clone ID Related Accession (Same CDS sequence)	NM_001001786.2 , NM_001001786.3
Accession Version	NM_001001786.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 327bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-01
Organism	Homo sapiens(human)
Product	BH3-like motif-containing cell death inducer
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF303179.1, BC130363.1 and AP001924.5. On May 17, 2019 this sequence version replaced NM_001001786.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: AF303179.1, BC130361.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: PMID: 15069058 MANE Ensembl match :: ENST00000560104.2/ ENSP00000453153.1 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGGTGACTT TGTTGCCTAT AGAGGGCCAG GAAATACATT TCTTTGAGAT CCTAGAATCT 
GAGTGTGTGC TCTACACAGG ATGGATAGAG CGAGCCTCTG GCAGTTCCAT TTATCCAGAG 
GCAAAAGCAC GCCTGCCACT GGAGGCGCTC TTGGGTTCCA ACAAAGAACC TATGTTGCCT 
AAGGAAACAG TGCTTTCTCT TAAAAGGTAC AATCTTGGCT CCTCTGCCAT GAAGCGGAAT 
GTTCCTGGAC ATGTGCTTCA GAGACCTTCC TATTTAACCA GGATACAAGT TACATTGTTA 
TGCAATTCCT CTGCTGAGGC CCTGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001001786.2
CDS	294..620
Translation	MVTLLPIEGQEIHFFEILESECVLYTGWIERASGSSIYPEAKARLPLEALLGSNKEPMLPKETVLSLKRYNLGSSAMKRNVPGHVLQRPSYLTRIQVTLLCNSSAEAL

Target ORF information:

RefSeq Version	NM_001001786.3
Organism	Homo sapiens(human)
Definition	Homo sapiens BH3-like motif containing, cell death inducer (BLID), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001001786.3

ORF Insert Sequence:

ATGGTGACTT TGTTGCCTAT AGAGGGCCAG GAAATACATT TCTTTGAGAT CCTAGAATCT 
GAGTGTGTGC TCTACACAGG ATGGATAGAG CGAGCCTCTG GCAGTTCCAT TTATCCAGAG 
GCAAAAGCAC GCCTGCCACT GGAGGCGCTC TTGGGTTCCA ACAAAGAACC TATGTTGCCT 
AAGGAAACAG TGCTTTCTCT TAAAAGGTAC AATCTTGGCT CCTCTGCCAT GAAGCGGAAT 
GTTCCTGGAC ATGTGCTTCA GAGACCTTCC TATTTAACCA GGATACAAGT TACATTGTTA 
TGCAATTCCT CTGCTGAGGC CCTGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

MicroRNA-575 targets BLID to promote growth and invasion of non-small cell lung cancer cells.
FEBS letters589(7)805-11(2015 Mar)
Wang H,Yan C,Shi X,Zheng J,Deng L,Yang L,Yu F,Yang Y,Shao Y

Aberrant BLID expression is associated with breast cancer progression.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine35(6)5449-52(2014 Jun)
Li X,Su P,Liu X,Kong X,Zhang X,Zhang H,Yang Q

BLID: A Novel Tumor-Suppressor Gene.
Oncology research22(5-6)333-8(2014)
Yu X,Li Z

BRCC2 inhibits breast cancer cell growth and metastasis in vitro and in vivo via downregulating AKT pathway.
Cell death & disease4e757(2013 Aug)
Li X,Kong X,Wang Y,Yang Q

Frequent loss of the BLID gene in early-onset breast cancer.
Cytogenetic and genome research135(1)19-24(2011)
Cavalli LR,Noone AM,Makambi KH,Rone JD,Kasid UN,Haddad BR

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BLID cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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