MAGOH cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	MAGOH
Entrez Gene ID	4116
Full Name	mago homolog, exon junction complex core component
Synonyms	MAGOH1,MAGOHA
General protein information	Preferred Names mago homolog, exon junction complex core component Names protein mago nashi homolog mago-nashi homolog, proliferation-associated
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1p32.3
Summary	Drosophila that have mutations in their mago nashi (grandchildless) gene produce progeny with defects in germplasm assembly and germline development. This gene encodes the mammalian mago nashi homolog. In mammals, mRNA expression is not limited to the germ plasm, but is expressed ubiquitously in adult tissues and can be induced by serum stimulation of quiescent fibroblasts. [provided by RefSeq, Jul 2008].
Disorder MIM:	602603

mRNA and Protein(s)

mRNA	Protein	Name
NM_002370.4	NP_002361.1	protein mago nashi homolog
NM_002370.3	NP_002361.1	protein mago nashi homolog

Pathways from BioSystems

Homologies

Homo sapiens (human)	MAGOH	NP_002361.1
Pan troglodytes (chimpanzee)	LOC100613301	XP_003308156.1
Canis lupus familiaris (dog)	MAGOH	XP_536702.1
Mus musculus (house mouse)	Magoh	NP_001269666.1
	MAGOH	XP_001112786.1
Bos taurus (cattle)	MAGOH	NP_001029417.1
Rattus norvegicus (Norway rat)	Magoh	NP_001094006.1
Gallus gallus (chicken)	MAGOH2	NP_989656.1

Gene Ontology
Bibliography

Related articles in PubMed

C-terminal short arginine/serine repeat sequence-dependent regulation of Y14 (RBM8A) localization.
Tatsuno T, Ishigaki Y
Scientific reports8(1)612(2018 Jan)

Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)

A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
Hein MY, Hubner NC, Poser I, Cox J, Nagaraj N, Toyoda Y, Gak IA, Weisswange I, Mansfeld J, Buchholz F, Hyman AA, Mann M
Cell163(3)712-23(2015 Oct)

A combined proteomics/genomics approach links hepatitis C virus infection with nonsense-mediated mRNA decay.
Ramage HR, Kumar GR, Verschueren E, Johnson JR, Von Dollen J, Johnson T, Newton B, Shah P, Horner J, Krogan NJ, Ott M
Molecular cell57(2)329-340(2015 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

findings show 2 genes MAGOH and MAGOHB are expressed in mammals; in macrophages, expression of MAGOHB but not MAGOH mRNA increases after LPS stimulation; both MAGOH proteins interact with other exon junction complex (EJC) components, incorporate into mRNA-bound EJCs and activate nonsense-mediated decay
Title: Two mammalian MAGOH genes contribute to exon junction complex composition and nonsense-mediated decay.

These results indicate that MAGOH regulates the transcriptional activation of STAT3 by interfering complex formation between STAT3 and Y14.
Title: The exon-junction complex proteins, Y14 and MAGOH regulate STAT3 activation.

crystal structure of a tetrameric exon junction core complex containing the DEAD-box adenosine triphosphatase eukaryotic initiation factor 4AIII bound to an ATP analog, MAGOH, Y14, a fragment of MLN51, and a polyuracil mRNA mimic
Title: Structure of the exon junction core complex with a trapped DEAD-box ATPase bound to RNA.

The stable association of multiprotein exon junction complex core with RNA is maintained by inhibition of eIF4AIII ATPase activity by MAGOH-Y14.
Title: The exon junction core complex is locked onto RNA by inhibition of eIF4AIII ATPase activity.

The following MAGOH gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MAGOH cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu17496	NM_002370.4 Latest version!	Homo sapiens mago homolog, exon junction complex subunit (MAGOH), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu17496	NM_002370.3	Homo sapiens mago homolog, exon junction complex core component (MAGOH), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

MAGOH ( NM_002370.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_002361.1 Homo sapiens mago homolog, exon junction complex subunit (MAGOH), mRNA.

Price & Availability↑

CloneID	OHu17496
Clone ID Related Accession (Same CDS sequence)	NM_002370.4 , NM_002370.3
Accession Version	NM_002370.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 441bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-10
Organism	Homo sapiens(human)
Product	protein mago nashi homolog
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF067173.1 and AF035940.1. On Nov 22, 2018 this sequence version replaced NM_002370.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: ERR279835.4540.1, BU533022.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000371470.8/ ENSP00000360525.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGAGAGTG ACTTTTATCT GCGTTACTAC GTGGGGCACA AGGGCAAGTT CGGCCACGAG 
TTCCTGGAGT TTGAGTTTCG ACCGGACGGG AAGTTAAGAT ATGCCAACAA CAGCAATTAC 
AAGAATGATG TCATGATCAG AAAAGAGGCT TATGTACATA AAAGCGTGAT GGAGGAACTG 
AAGAGAATAA TTGACGACAG TGAAATTACC AAAGAGGATG ATGCATTGTG GCCTCCTCCT 
GACCGAGTGG GCCGGCAGGA GCTTGAAATC GTCATTGGAG ATGAACACAT TTCTTTTACA 
ACATCAAAAA TTGGTTCCCT TATTGATGTC AATCAATCCA AGGATCCAGA AGGCTTACGA 
GTATTTTATT ATCTTGTCCA GGACCTGAAG TGTTTGGTCT TCAGTCTTAT TGGATTACAC 
TTCAAGATTA AACCAATCTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002361.1
CDS	71..511
Translation	MESDFYLRYYVGHKGKFGHEFLEFEFRPDGKLRYANNSNYKNDVMIRKEAYVHKSVMEELKRIIDDSEITKEDDALWPPPDRVGRQELEIVIGDEHISFTTSKIGSLIDVNQSKDPEGLRVFYYLVQDLKCLVFSLIGLHFKIKPI

Target ORF information:

RefSeq Version	NM_002370.4
Organism	Homo sapiens(human)
Definition	Homo sapiens mago homolog, exon junction complex subunit (MAGOH), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002370.4

ORF Insert Sequence:

ATGGAGAGTG ACTTTTATCT GCGTTACTAC GTGGGGCACA AGGGCAAGTT CGGCCACGAG 
TTCCTGGAGT TTGAGTTTCG ACCGGACGGG AAGTTAAGAT ATGCCAACAA CAGCAATTAC 
AAGAATGATG TCATGATCAG AAAAGAGGCT TATGTACATA AAAGCGTGAT GGAGGAACTG 
AAGAGAATAA TTGACGACAG TGAAATTACC AAAGAGGATG ATGCATTGTG GCCTCCTCCT 
GACCGAGTGG GCCGGCAGGA GCTTGAAATC GTCATTGGAG ATGAACACAT TTCTTTTACA 
ACATCAAAAA TTGGTTCCCT TATTGATGTC AATCAATCCA AGGATCCAGA AGGCTTACGA 
GTATTTTATT ATCTTGTCCA GGACCTGAAG TGTTTGGTCT TCAGTCTTAT TGGATTACAC 
TTCAAGATTA AACCAATCTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MAGOH ( NM_002370.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_002361.1 Homo sapiens mago homolog, exon junction complex core component (MAGOH), mRNA.

Price & Availability↑

CloneID	OHu17496
Clone ID Related Accession (Same CDS sequence)	NM_002370.4 , NM_002370.3
Accession Version	NM_002370.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 441bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	protein mago nashi homolog
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BX283982.1, AF067173.1 and AF035940.1. On Jan 28, 2011 this sequence version replaced NM_002370.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF035940.1, BM808411.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END##

ATGGAGAGTG ACTTTTATCT GCGTTACTAC GTGGGGCACA AGGGCAAGTT CGGCCACGAG 
TTCCTGGAGT TTGAGTTTCG ACCGGACGGG AAGTTAAGAT ATGCCAACAA CAGCAATTAC 
AAGAATGATG TCATGATCAG AAAAGAGGCT TATGTACATA AAAGCGTGAT GGAGGAACTG 
AAGAGAATAA TTGACGACAG TGAAATTACC AAAGAGGATG ATGCATTGTG GCCTCCTCCT 
GACCGAGTGG GCCGGCAGGA GCTTGAAATC GTCATTGGAG ATGAACACAT TTCTTTTACA 
ACATCAAAAA TTGGTTCCCT TATTGATGTC AATCAATCCA AGGATCCAGA AGGCTTACGA 
GTATTTTATT ATCTTGTCCA GGACCTGAAG TGTTTGGTCT TCAGTCTTAT TGGATTACAC 
TTCAAGATTA AACCAATCTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002361.1
CDS	163..603
Translation	MESDFYLRYYVGHKGKFGHEFLEFEFRPDGKLRYANNSNYKNDVMIRKEAYVHKSVMEELKRIIDDSEITKEDDALWPPPDRVGRQELEIVIGDEHISFTTSKIGSLIDVNQSKDPEGLRVFYYLVQDLKCLVFSLIGLHFKIKPI

Target ORF information:

RefSeq Version	NM_002370.3
Organism	Homo sapiens(human)
Definition	Homo sapiens mago homolog, exon junction complex core component (MAGOH), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002370.3

ORF Insert Sequence:

ATGGAGAGTG ACTTTTATCT GCGTTACTAC GTGGGGCACA AGGGCAAGTT CGGCCACGAG 
TTCCTGGAGT TTGAGTTTCG ACCGGACGGG AAGTTAAGAT ATGCCAACAA CAGCAATTAC 
AAGAATGATG TCATGATCAG AAAAGAGGCT TATGTACATA AAAGCGTGAT GGAGGAACTG 
AAGAGAATAA TTGACGACAG TGAAATTACC AAAGAGGATG ATGCATTGTG GCCTCCTCCT 
GACCGAGTGG GCCGGCAGGA GCTTGAAATC GTCATTGGAG ATGAACACAT TTCTTTTACA 
ACATCAAAAA TTGGTTCCCT TATTGATGTC AATCAATCCA AGGATCCAGA AGGCTTACGA 
GTATTTTATT ATCTTGTCCA GGACCTGAAG TGTTTGGTCT TCAGTCTTAT TGGATTACAC 
TTCAAGATTA AACCAATCTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

C-terminal short arginine/serine repeat sequence-dependent regulation of Y14 (RBM8A) localization.
Scientific reports8(1)612(2018 Jan)
Tatsuno T,Ishigaki Y

Architecture of the human interactome defines protein communities and disease networks.
Nature545(7655)505-509(2017 05)
Huttlin EL,Bruckner RJ,Paulo JA,Cannon JR,Ting L,Baltier K,Colby G,Gebreab F,Gygi MP,Parzen H,Szpyt J,Tam S,Zarraga G,Pontano-Vaites L,Swarup S,White AE,Schweppe DK,Rad R,Erickson BK,Obar RA,Guruharsha KG,Li K,Artavanis-Tsakonas S,Gygi SP,Harper JW

A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
Cell163(3)712-23(2015 Oct)
Hein MY,Hubner NC,Poser I,Cox J,Nagaraj N,Toyoda Y,Gak IA,Weisswange I,Mansfeld J,Buchholz F,Hyman AA,Mann M

A combined proteomics/genomics approach links hepatitis C virus infection with nonsense-mediated mRNA decay.
Molecular cell57(2)329-340(2015 Jan)
Ramage HR,Kumar GR,Verschueren E,Johnson JR,Von Dollen J,Johnson T,Newton B,Shah P,Horner J,Krogan NJ,Ott M

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MAGOH cDNA ORF clone, Homo sapiens(human)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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