MAB21L1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	MAB21L1
Entrez Gene ID	4081
Full Name	mab-21 like 1
Synonyms	CAGR1,Nbla00126
General protein information	Preferred Names mab-21 like 1 Names putative nucleotidyltransferase MAB21L1 mab-21-like protein 1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 13 Map Location: 13q13.3
Summary	This gene is similar to the MAB-21 cell fate-determining gene found in C. elegans. It may be involved in eye and cerebellum development, and it has been proposed that expansion of a trinucleotide repeat region in the 5' UTR may play a role in a variety of psychiatric disorders. [provided by RefSeq, Oct 2008].
Disorder MIM:	601280

mRNA and Protein(s)

mRNA	Protein	Name
NM_005584.5	NP_005575.1	putative nucleotidyltransferase MAB21L1
NM_005584.4	NP_005575.1	putative nucleotidyltransferase MAB21L1

Pathways from BioSystems

Homologies

Bos taurus (cattle)	MAB21L1	NP_001091579.1
Caenorhabditis elegans (roundworm)	mab-21	NP_497940.2
Pan troglodytes (chimpanzee)	MAB21L1	XP_522656.2
Gallus gallus (chicken)	MAB21L1	NP_989864.1
Danio rerio (zebrafish)	mab21l1	NP_694506.2
Xenopus tropicalis (tropical clawed frog)	mab21l1	NP_001072797.1
	MAB21L1	XP_001102683.1
Mus musculus (house mouse)	Mab21l1	NP_034880.1
Homo sapiens (human)	MAB21L1	NP_005575.1
Canis lupus familiaris (dog)	MAB21L1	XP_543137.1
Drosophila melanogaster (fruit fly)	mab-21	NP_651971.2
Anopheles gambiae (African malaria mosquito)	MAB21_ANOGA	XP_560259.3
Rattus norvegicus (Norway rat)	Mab21l1	NP_001102967.1

Gene Ontology
Bibliography

Related articles in PubMed

Involvement of the Mab21l1 gene in calvarial osteogenesis.
Nguyen D, Yamada R, Yoshimitsu N, Oguri A, Kojima T, Takahashi N
Differentiation; research in biological diversity9870-78(2017 Nov - Dec)

Autosomal recessive truncating MAB21L1 mutation associated with a syndromic scrotal agenesis.
Bruel AL, Masurel-Paulet A, Rivi?re JB, Duffourd Y, Lehalle D, Bensignor C, Huet F, Borgnon J, Roucher F, Kuentz P, Deleuze JF, Thauvin-Robinet C, Faivre L, Thevenon J
Clinical genetics91(2)333-338(2017 Feb)

Structural and biochemical characterization of the cell fate determining nucleotidyltransferase fold protein MAB21L1.
de Oliveira Mann CC, Kiefersauer R, Witte G, Hopfner KP
Scientific reports627498(2016 Jun)

The Male Abnormal Gene Family 21 (Mab21) Members Regulate Eye Development.
Huang ZX, Xiang JW, Zhou L, Nie Q, Wang L, Chen ZG, Hu XH, Xiao Y, Qing WJ, Liu YF, Sun Q, Tang XC, Liu FY, Luo ZW, Liu WB, Li DW
Current molecular medicine16(7)660-667(2016)

Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method.
Oshikawa M, Tsutsui C, Ikegami T, Fuchida Y, Matsubara M, Toyama S, Usami R, Ohtoko K, Kato S
Investigative ophthalmology & visual science52(9)6662-70(2011 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

We hypothesize that MAB21L1 haploinsufficiency cause a previously undescribed syndrome with scrotal agenesis, ophthalmological anomalies, facial dysmorphism and gross psychomotor delay as remarkable hallmarks.
Title: Autosomal recessive truncating MAB21L1 mutation associated with a syndromic scrotal agenesis.

mab21 gene family members, mab21l1 and mab21l2, play important roles in regulating eye development. [review]
Title: The Male Abnormal Gene Family 21 (Mab21) Members Regulate Eye Development.

MEF is involved in PTH suppression of osteoblasts through activating the MKK4/JNK1 pathway and subsequently up-regulating Mab21l1 expression.
Title: PTH regulates myleoid ELF-1-like factor (MEF)-induced MAB-21-like-1 (MAB21L1) expression through the JNK1 pathway.

Observational study of gene-disease association. (HuGE Navigator)
Title: Association and linkage studies between bipolar affective disorder and the polymorphic CAG/CTG repeat loci ERDA1, SEF2-1B, MAB21L and KCNN3.

The following MAB21L1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MAB21L1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu22840	NM_005584.5 Latest version!	Homo sapiens mab-21 like 1 (MAB21L1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
View Old Accession Versions >>
OHu22840	NM_005584.4	Homo sapiens mab-21 like 1 (MAB21L1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

MAB21L1 ( NM_005584.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_005575.1 Homo sapiens mab-21 like 1 (MAB21L1), mRNA.

Price & Availability↑

CloneID	OHu22840
Clone ID Related Accession (Same CDS sequence)	NM_005584.5 , NM_005584.4
Accession Version	NM_005584.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1080bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-24
Organism	Homo sapiens(human)
Product	putative nucleotidyltransferase MAB21L1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK313185.1 and AL390071.9. This sequence is a reference standard in the RefSeqGene project. On May 17, 2019 this sequence version replaced NM_005584.4. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: AB593022.1, SRR1803612.21536.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000379919.6/ ENSP00000369251.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGATTGCGG CCCAGGCCAA GCTGGTCTAC CATCTGAATA AATACTACAA CGAAAAATGC 
CAAGCCAGGA AAGCTGCCAT TGCCAAAACT ATCCGGGAAG TCTGCAAAGT AGTTTCCGAC 
GTACTGAAGG AAGTGGAAGT GCAGGAGCCG CGGTTCATCA GCTCTCTCAA CGAGATGGAC 
AATCGCTACG AGGGCCTCGA GGTCATCTCC CCCACCGAAT TTGAAGTGGT GCTTTATCTC 
AACCAAATGG GGGTGTTCAA CTTCGTGGAC GATGGCTCAC TGCCCGGCTG CGCGGTGCTG 
AAGTTGAGCG ACGGGCGCAA GAGGAGCATG TCCCTCTGGG TGGAATTCAT TACCGCCTCC 
GGCTACCTCT CGGCGCGCAA AATCCGGTCC AGGTTTCAGA CGCTGGTGGC TCAAGCGGTA 
GACAAATGTA GCTACCGGGA TGTGGTAAAG ATGGTGGCAG ACACCAGCGA AGTGAAACTG 
AGAATCCGAG ATAGGTACGT GGTGCAGATC ACGCCGGCCT TTAAATGCAC CGGGATCTGG 
CCGAGGAGTG CTGCCCACTG GCCACTTCCC CACATCCCCT GGCCGGGACC CAACCGGGTG 
GCGGAGGTCA AGGCGGAAGG TTTCAATCTC TTGTCCAAGG AGTGCCACTC CTTGGCCGGC 
AAGCAGAGCT CGGCGGAGAG CGACGCCTGG GTGCTGCAGT TCGCGGAGGC AGAGAACAGA 
CTGCAGATGG GGGGCTGCAG AAAGAAGTGC CTCTCCATCC TCAAAACCTT AAGGGATCGT 
CACCTTGAAC TGCCGGGCCA GCCCTTGAAC AATTACCATA TGAAGACTCT GGTTTCCTAC 
GAGTGTGAAA AGCATCCCCG AGAGTCGGAC TGGGACGAGT CTTGCCTGGG TGATCGGCTG 
AACGGGATTT TGCTGCAACT TATCTCCTGC CTGCAGTGCC GGCGGTGTCC CCACTACTTT 
CTACCGAACT TAGATCTGTT TCAAGGCAAA CCTCACTCAG CTCTGGAAAA CGCTGCCAAA 
CAAACGTGGC GACTGGCAAG AGAGATCCTG ACCAACCCGA AAAGTTTGGA AAAACTTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005575.1
CDS	552..1631
Translation	MIAAQAKLVYHLNKYYNEKCQARKAAIAKTIREVCKVVSDVLKEVEVQEPRFISSLNEMDNRYEGLEVISPTEFEVVLYLNQMGVFNFVDDGSLPGCAVLKLSDGRKRSMSLWVEFITASGYLSARKIRSRFQTLVAQAVDKCSYRDVVKMVADTSEVKLRIRDRYVVQITPAFKCTGIWPRSAAHWPLPHIPWPGPNRVAEVKAEGFNLLSKECHSLAGKQSSAESDAWVLQFAEAENRLQMGGCRKKCLSILKTLRDRHLELPGQPLNNYHMKTLVSYECEKHPRESDWDESCLGDRLNGILLQLISCLQCRRCPHYFLPNLDLFQGKPHSALENAAKQTWRLAREILTNPKSLEKL

Target ORF information:

RefSeq Version	NM_005584.5
Organism	Homo sapiens(human)
Definition	Homo sapiens mab-21 like 1 (MAB21L1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005584.5

ORF Insert Sequence:

ATGATTGCGG CCCAGGCCAA GCTGGTCTAC CATCTGAATA AATACTACAA CGAAAAATGC 
CAAGCCAGGA AAGCTGCCAT TGCCAAAACT ATCCGGGAAG TCTGCAAAGT AGTTTCCGAC 
GTACTGAAGG AAGTGGAAGT GCAGGAGCCG CGGTTCATCA GCTCTCTCAA CGAGATGGAC 
AATCGCTACG AGGGCCTCGA GGTCATCTCC CCCACCGAAT TTGAAGTGGT GCTTTATCTC 
AACCAAATGG GGGTGTTCAA CTTCGTGGAC GATGGCTCAC TGCCCGGCTG CGCGGTGCTG 
AAGTTGAGCG ACGGGCGCAA GAGGAGCATG TCCCTCTGGG TGGAATTCAT TACCGCCTCC 
GGCTACCTCT CGGCGCGCAA AATCCGGTCC AGGTTTCAGA CGCTGGTGGC TCAAGCGGTA 
GACAAATGTA GCTACCGGGA TGTGGTAAAG ATGGTGGCAG ACACCAGCGA AGTGAAACTG 
AGAATCCGAG ATAGGTACGT GGTGCAGATC ACGCCGGCCT TTAAATGCAC CGGGATCTGG 
CCGAGGAGTG CTGCCCACTG GCCACTTCCC CACATCCCCT GGCCGGGACC CAACCGGGTG 
GCGGAGGTCA AGGCGGAAGG TTTCAATCTC TTGTCCAAGG AGTGCCACTC CTTGGCCGGC 
AAGCAGAGCT CGGCGGAGAG CGACGCCTGG GTGCTGCAGT TCGCGGAGGC AGAGAACAGA 
CTGCAGATGG GGGGCTGCAG AAAGAAGTGC CTCTCCATCC TCAAAACCTT AAGGGATCGT 
CACCTTGAAC TGCCGGGCCA GCCCTTGAAC AATTACCATA TGAAGACTCT GGTTTCCTAC 
GAGTGTGAAA AGCATCCCCG AGAGTCGGAC TGGGACGAGT CTTGCCTGGG TGATCGGCTG 
AACGGGATTT TGCTGCAACT TATCTCCTGC CTGCAGTGCC GGCGGTGTCC CCACTACTTT 
CTACCGAACT TAGATCTGTT TCAAGGCAAA CCTCACTCAG CTCTGGAAAA CGCTGCCAAA 
CAAACGTGGC GACTGGCAAG AGAGATCCTG ACCAACCCGA AAAGTTTGGA AAAACTTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MAB21L1 ( NM_005584.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_005575.1 Homo sapiens mab-21 like 1 (MAB21L1), mRNA.

Price & Availability↑

CloneID	OHu22840
Clone ID Related Accession (Same CDS sequence)	NM_005584.5 , NM_005584.4
Accession Version	NM_005584.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1080bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-08-11
Organism	Homo sapiens(human)
Product	putative nucleotidyltransferase MAB21L1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA611205.1, AK313185.1 and AL390071.9. This sequence is a reference standard in the RefSeqGene project. On Mar 25, 2010 this sequence version replaced NM_005584.3. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. COMPLETENESS: complete on the 3' end.

ATGATTGCGG CCCAGGCCAA GCTGGTCTAC CATCTGAATA AATACTACAA CGAAAAATGC 
CAAGCCAGGA AAGCTGCCAT TGCCAAAACT ATCCGGGAAG TCTGCAAAGT AGTTTCCGAC 
GTACTGAAGG AAGTGGAAGT GCAGGAGCCG CGGTTCATCA GCTCTCTCAA CGAGATGGAC 
AATCGCTACG AGGGCCTCGA GGTCATCTCC CCCACCGAAT TTGAAGTGGT GCTTTATCTC 
AACCAAATGG GGGTGTTCAA CTTCGTGGAC GATGGCTCAC TGCCCGGCTG CGCGGTGCTG 
AAGTTGAGCG ACGGGCGCAA GAGGAGCATG TCCCTCTGGG TGGAATTCAT TACCGCCTCC 
GGCTACCTCT CGGCGCGCAA AATCCGGTCC AGGTTTCAGA CGCTGGTGGC TCAAGCGGTA 
GACAAATGTA GCTACCGGGA TGTGGTAAAG ATGGTGGCAG ACACCAGCGA AGTGAAACTG 
AGAATCCGAG ATAGGTACGT GGTGCAGATC ACGCCGGCCT TTAAATGCAC CGGGATCTGG 
CCGAGGAGTG CTGCCCACTG GCCACTTCCC CACATCCCCT GGCCGGGACC CAACCGGGTG 
GCGGAGGTCA AGGCGGAAGG TTTCAATCTC TTGTCCAAGG AGTGCCACTC CTTGGCCGGC 
AAGCAGAGCT CGGCGGAGAG CGACGCCTGG GTGCTGCAGT TCGCGGAGGC AGAGAACAGA 
CTGCAGATGG GGGGCTGCAG AAAGAAGTGC CTCTCCATCC TCAAAACCTT AAGGGATCGT 
CACCTTGAAC TGCCGGGCCA GCCCTTGAAC AATTACCATA TGAAGACTCT GGTTTCCTAC 
GAGTGTGAAA AGCATCCCCG AGAGTCGGAC TGGGACGAGT CTTGCCTGGG TGATCGGCTG 
AACGGGATTT TGCTGCAACT TATCTCCTGC CTGCAGTGCC GGCGGTGTCC CCACTACTTT 
CTACCGAACT TAGATCTGTT TCAAGGCAAA CCTCACTCAG CTCTGGAAAA CGCTGCCAAA 
CAAACGTGGC GACTGGCAAG AGAGATCCTG ACCAACCCGA AAAGTTTGGA AAAACTTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005575.1
CDS	558..1637
Translation	MIAAQAKLVYHLNKYYNEKCQARKAAIAKTIREVCKVVSDVLKEVEVQEPRFISSLNEMDNRYEGLEVISPTEFEVVLYLNQMGVFNFVDDGSLPGCAVLKLSDGRKRSMSLWVEFITASGYLSARKIRSRFQTLVAQAVDKCSYRDVVKMVADTSEVKLRIRDRYVVQITPAFKCTGIWPRSAAHWPLPHIPWPGPNRVAEVKAEGFNLLSKECHSLAGKQSSAESDAWVLQFAEAENRLQMGGCRKKCLSILKTLRDRHLELPGQPLNNYHMKTLVSYECEKHPRESDWDESCLGDRLNGILLQLISCLQCRRCPHYFLPNLDLFQGKPHSALENAAKQTWRLAREILTNPKSLEKL

Target ORF information:

RefSeq Version	NM_005584.4
Organism	Homo sapiens(human)
Definition	Homo sapiens mab-21 like 1 (MAB21L1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005584.4

ORF Insert Sequence:

ATGATTGCGG CCCAGGCCAA GCTGGTCTAC CATCTGAATA AATACTACAA CGAAAAATGC 
CAAGCCAGGA AAGCTGCCAT TGCCAAAACT ATCCGGGAAG TCTGCAAAGT AGTTTCCGAC 
GTACTGAAGG AAGTGGAAGT GCAGGAGCCG CGGTTCATCA GCTCTCTCAA CGAGATGGAC 
AATCGCTACG AGGGCCTCGA GGTCATCTCC CCCACCGAAT TTGAAGTGGT GCTTTATCTC 
AACCAAATGG GGGTGTTCAA CTTCGTGGAC GATGGCTCAC TGCCCGGCTG CGCGGTGCTG 
AAGTTGAGCG ACGGGCGCAA GAGGAGCATG TCCCTCTGGG TGGAATTCAT TACCGCCTCC 
GGCTACCTCT CGGCGCGCAA AATCCGGTCC AGGTTTCAGA CGCTGGTGGC TCAAGCGGTA 
GACAAATGTA GCTACCGGGA TGTGGTAAAG ATGGTGGCAG ACACCAGCGA AGTGAAACTG 
AGAATCCGAG ATAGGTACGT GGTGCAGATC ACGCCGGCCT TTAAATGCAC CGGGATCTGG 
CCGAGGAGTG CTGCCCACTG GCCACTTCCC CACATCCCCT GGCCGGGACC CAACCGGGTG 
GCGGAGGTCA AGGCGGAAGG TTTCAATCTC TTGTCCAAGG AGTGCCACTC CTTGGCCGGC 
AAGCAGAGCT CGGCGGAGAG CGACGCCTGG GTGCTGCAGT TCGCGGAGGC AGAGAACAGA 
CTGCAGATGG GGGGCTGCAG AAAGAAGTGC CTCTCCATCC TCAAAACCTT AAGGGATCGT 
CACCTTGAAC TGCCGGGCCA GCCCTTGAAC AATTACCATA TGAAGACTCT GGTTTCCTAC 
GAGTGTGAAA AGCATCCCCG AGAGTCGGAC TGGGACGAGT CTTGCCTGGG TGATCGGCTG 
AACGGGATTT TGCTGCAACT TATCTCCTGC CTGCAGTGCC GGCGGTGTCC CCACTACTTT 
CTACCGAACT TAGATCTGTT TCAAGGCAAA CCTCACTCAG CTCTGGAAAA CGCTGCCAAA 
CAAACGTGGC GACTGGCAAG AGAGATCCTG ACCAACCCGA AAAGTTTGGA AAAACTTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Involvement of the Mab21l1 gene in calvarial osteogenesis.
Differentiation; research in biological diversity9870-78(2017 Nov - Dec)
Nguyen D,Yamada R,Yoshimitsu N,Oguri A,Kojima T,Takahashi N

Autosomal recessive truncating MAB21L1 mutation associated with a syndromic scrotal agenesis.
Clinical genetics91(2)333-338(2017 Feb)
Bruel AL,Masurel-Paulet A,Rivi?re JB,Duffourd Y,Lehalle D,Bensignor C,Huet F,Borgnon J,Roucher F,Kuentz P,Deleuze JF,Thauvin-Robinet C,Faivre L,Thevenon J

Structural and biochemical characterization of the cell fate determining nucleotidyltransferase fold protein MAB21L1.
Scientific reports627498(2016 Jun)
de Oliveira Mann CC,Kiefersauer R,Witte G,Hopfner KP

The Male Abnormal Gene Family 21 (Mab21) Members Regulate Eye Development.
Current molecular medicine16(7)660-667(2016)
Huang ZX,Xiang JW,Zhou L,Nie Q,Wang L,Chen ZG,Hu XH,Xiao Y,Qing WJ,Liu YF,Sun Q,Tang XC,Liu FY,Luo ZW,Liu WB,Li DW

Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method.
Investigative ophthalmology & visual science52(9)6662-70(2011 Aug)
Oshikawa M,Tsutsui C,Ikegami T,Fuchida Y,Matsubara M,Toyama S,Usami R,Ohtoko K,Kato S

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MAB21L1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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