EPCAM cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	EPCAM
Entrez Gene ID	4072
Full Name	epithelial cell adhesion molecule
Synonyms	DIAR5,EGP-2,EGP314,EGP40,ESA,HNPCC8,KS1/4,KSA,M4S1,MIC18,MK-1,TACSTD1,TROP1
General protein information	Preferred Names epithelial cell adhesion molecule Names epithelial cell adhesion molecule adenocarcinoma-associated antigen cell surface glycoprotein Trop-1 epithelial glycoprotein 314 human epithelial glycoprotein-2 major gastrointestinal tumor-associated protein GA733-2 membrane component, chromosome 4, surface marker (35kD glycoprotein) tumor-associated calcium signal transducer 1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 2 Map Location: 2p21
Summary	This gene encodes a carcinoma-associated antigen and is a member of a family that includes at least two type I membrane proteins. This antigen is expressed on most normal epithelial cells and gastrointestinal carcinomas and functions as a homotypic calcium-independent cell adhesion molecule. The antigen is being used as a target for immunotherapy treatment of human carcinomas. Mutations in this gene result in congenital tufting enteropathy. [provided by RefSeq, Dec 2008].
Disorder MIM:	185535
Disorder Html:	Diarrhea 5, with tufting enteropathy, congenital, 613217 (3); Colorectal cancer, hereditary nonpolyposis, type 8, 613244 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_002354.3	NP_002345.2	epithelial cell adhesion molecule precursor
NM_002354.2	NP_002345.2	epithelial cell adhesion molecule precursor

Pathways from BioSystems

Homologies

Danio rerio (zebrafish)	epcam	NP_001017593.1
Homo sapiens (human)	EPCAM	NP_002345.2
	EPCAM	NP_001035118.1
Canis lupus familiaris (dog)	EPCAM	XP_005626295.1
Mus musculus (house mouse)	Epcam	NP_032558.2
Rattus norvegicus (Norway rat)	Epcam	NP_612550.1
Pan troglodytes (chimpanzee)	EPCAM	XP_515458.2
Bos taurus (cattle)	EPCAM	NP_001030367.1
Gallus gallus (chicken)	EPCAM	NP_001012582.1
Xenopus tropicalis (tropical clawed frog)	epcam	NP_001011149.1

Gene Ontology

The following EPCAM gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the EPCAM cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu23712	NM_002354.3 Latest version!	Homo sapiens epithelial cell adhesion molecule (EPCAM), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
View Old Accession Versions >>
OHu23712	NM_002354.2	Homo sapiens epithelial cell adhesion molecule (EPCAM), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

EPCAM ( NM_002354.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_002345.2 Homo sapiens epithelial cell adhesion molecule (EPCAM), mRNA.

Price & Availability↑

CloneID	OHu23712
Clone ID Related Accession (Same CDS sequence)	NM_002354.3 , NM_002354.2
Accession Version	NM_002354.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 945bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-04
Organism	Homo sapiens(human)
Product	epithelial cell adhesion molecule precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP262680.1, BC014785.1, DA963872.1 and AW050533.1. On Aug 31, 2019 this sequence version replaced NM_002354.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK026585.1, M26481.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCGCCCC CGCAGGTCCT CGCGTTCGGG CTTCTGCTTG CCGCGGCGAC GGCGACTTTT 
GCCGCAGCTC AGGAAGAATG TGTCTGTGAA AACTACAAGC TGGCCGTAAA CTGCTTTGTG 
AATAATAATC GTCAATGCCA GTGTACTTCA GTTGGTGCAC AAAATACTGT CATTTGCTCA 
AAGCTGGCTG CCAAATGTTT GGTGATGAAG GCAGAAATGA ATGGCTCAAA ACTTGGGAGA 
AGAGCAAAAC CTGAAGGGGC CCTCCAGAAC AATGATGGGC TTTATGATCC TGACTGCGAT 
GAGAGCGGGC TCTTTAAGGC CAAGCAGTGC AACGGCACCT CCATGTGCTG GTGTGTGAAC 
ACTGCTGGGG TCAGAAGAAC AGACAAGGAC ACTGAAATAA CCTGCTCTGA GCGAGTGAGA 
ACCTACTGGA TCATCATTGA ACTAAAACAC AAAGCAAGAG AAAAACCTTA TGATAGTAAA 
AGTTTGCGGA CTGCACTTCA GAAGGAGATC ACAACGCGTT ATCAACTGGA TCCAAAATTT 
ATCACGAGTA TTTTGTATGA GAATAATGTT ATCACTATTG ATCTGGTTCA AAATTCTTCT 
CAAAAAACTC AGAATGATGT GGACATAGCT GATGTGGCTT ATTATTTTGA AAAAGATGTT 
AAAGGTGAAT CCTTGTTTCA TTCTAAGAAA ATGGACCTGA CAGTAAATGG GGAACAACTG 
GATCTGGATC CTGGTCAAAC TTTAATTTAT TATGTTGATG AAAAAGCACC TGAATTCTCA 
ATGCAGGGTC TAAAAGCTGG TGTTATTGCT GTTATTGTGG TTGTGGTGAT AGCAGTTGTT 
GCTGGAATTG TTGTGCTGGT TATTTCCAGA AAGAAGAGAA TGGCAAAGTA TGAGAAGGCT 
GAGATAAAGG AGATGGGTGA GATGCATAGG GAACTCAATG CATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002345.2
CDS	196..1140
Translation	MAPPQVLAFGLLLAAATATFAAAQEECVCENYKLAVNCFVNNNRQCQCTSVGAQNTVICSKLAAKCLVMKAEMNGSKLGRRAKPEGALQNNDGLYDPDCDESGLFKAKQCNGTSMCWCVNTAGVRRTDKDTEITCSERVRTYWIIIELKHKAREKPYDSKSLRTALQKEITTRYQLDPKFITSILYENNVITIDLVQNSSQKTQNDVDIADVAYYFEKDVKGESLFHSKKMDLTVNGEQLDLDPGQTLIYYVDEKAPEFSMQGLKAGVIAVIVVVVIAVVAGIVVLVISRKKRMAKYEKAEIKEMGEMHRELNA

Target ORF information:

RefSeq Version	NM_002354.3
Organism	Homo sapiens(human)
Definition	Homo sapiens epithelial cell adhesion molecule (EPCAM), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002354.3

ORF Insert Sequence:

ATGGCGCCCC CGCAGGTCCT CGCGTTCGGG CTTCTGCTTG CCGCGGCGAC GGCGACTTTT 
GCCGCAGCTC AGGAAGAATG TGTCTGTGAA AACTACAAGC TGGCCGTAAA CTGCTTTGTG 
AATAATAATC GTCAATGCCA GTGTACTTCA GTTGGTGCAC AAAATACTGT CATTTGCTCA 
AAGCTGGCTG CCAAATGTTT GGTGATGAAG GCAGAAATGA ATGGCTCAAA ACTTGGGAGA 
AGAGCAAAAC CTGAAGGGGC CCTCCAGAAC AATGATGGGC TTTATGATCC TGACTGCGAT 
GAGAGCGGGC TCTTTAAGGC CAAGCAGTGC AACGGCACCT CCATGTGCTG GTGTGTGAAC 
ACTGCTGGGG TCAGAAGAAC AGACAAGGAC ACTGAAATAA CCTGCTCTGA GCGAGTGAGA 
ACCTACTGGA TCATCATTGA ACTAAAACAC AAAGCAAGAG AAAAACCTTA TGATAGTAAA 
AGTTTGCGGA CTGCACTTCA GAAGGAGATC ACAACGCGTT ATCAACTGGA TCCAAAATTT 
ATCACGAGTA TTTTGTATGA GAATAATGTT ATCACTATTG ATCTGGTTCA AAATTCTTCT 
CAAAAAACTC AGAATGATGT GGACATAGCT GATGTGGCTT ATTATTTTGA AAAAGATGTT 
AAAGGTGAAT CCTTGTTTCA TTCTAAGAAA ATGGACCTGA CAGTAAATGG GGAACAACTG 
GATCTGGATC CTGGTCAAAC TTTAATTTAT TATGTTGATG AAAAAGCACC TGAATTCTCA 
ATGCAGGGTC TAAAAGCTGG TGTTATTGCT GTTATTGTGG TTGTGGTGAT AGCAGTTGTT 
GCTGGAATTG TTGTGCTGGT TATTTCCAGA AAGAAGAGAA TGGCAAAGTA TGAGAAGGCT 
GAGATAAAGG AGATGGGTGA GATGCATAGG GAACTCAATG CATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

EPCAM ( NM_002354.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_002345.2 Homo sapiens epithelial cell adhesion molecule (EPCAM), mRNA.

Price & Availability↑

CloneID	OHu23712
Clone ID Related Accession (Same CDS sequence)	NM_002354.3 , NM_002354.2
Accession Version	NM_002354.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 945bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-07-02
Organism	Homo sapiens(human)
Product	epithelial cell adhesion molecule precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB044092.1, BP262680.1, BC014785.1, DA963872.1 and AW050533.1. This sequence is a reference standard in the RefSeqGene project. On Dec 19, 2008 this sequence version replaced NM_002354.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK026585.1, ERR279847.3142.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCGCCCC CGCAGGTCCT CGCGTTCGGG CTTCTGCTTG CCGCGGCGAC GGCGACTTTT 
GCCGCAGCTC AGGAAGAATG TGTCTGTGAA AACTACAAGC TGGCCGTAAA CTGCTTTGTG 
AATAATAATC GTCAATGCCA GTGTACTTCA GTTGGTGCAC AAAATACTGT CATTTGCTCA 
AAGCTGGCTG CCAAATGTTT GGTGATGAAG GCAGAAATGA ATGGCTCAAA ACTTGGGAGA 
AGAGCAAAAC CTGAAGGGGC CCTCCAGAAC AATGATGGGC TTTATGATCC TGACTGCGAT 
GAGAGCGGGC TCTTTAAGGC CAAGCAGTGC AACGGCACCT CCATGTGCTG GTGTGTGAAC 
ACTGCTGGGG TCAGAAGAAC AGACAAGGAC ACTGAAATAA CCTGCTCTGA GCGAGTGAGA 
ACCTACTGGA TCATCATTGA ACTAAAACAC AAAGCAAGAG AAAAACCTTA TGATAGTAAA 
AGTTTGCGGA CTGCACTTCA GAAGGAGATC ACAACGCGTT ATCAACTGGA TCCAAAATTT 
ATCACGAGTA TTTTGTATGA GAATAATGTT ATCACTATTG ATCTGGTTCA AAATTCTTCT 
CAAAAAACTC AGAATGATGT GGACATAGCT GATGTGGCTT ATTATTTTGA AAAAGATGTT 
AAAGGTGAAT CCTTGTTTCA TTCTAAGAAA ATGGACCTGA CAGTAAATGG GGAACAACTG 
GATCTGGATC CTGGTCAAAC TTTAATTTAT TATGTTGATG AAAAAGCACC TGAATTCTCA 
ATGCAGGGTC TAAAAGCTGG TGTTATTGCT GTTATTGTGG TTGTGGTGAT AGCAGTTGTT 
GCTGGAATTG TTGTGCTGGT TATTTCCAGA AAGAAGAGAA TGGCAAAGTA TGAGAAGGCT 
GAGATAAAGG AGATGGGTGA GATGCATAGG GAACTCAATG CATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002345.2
CDS	359..1303
Translation	MAPPQVLAFGLLLAAATATFAAAQEECVCENYKLAVNCFVNNNRQCQCTSVGAQNTVICSKLAAKCLVMKAEMNGSKLGRRAKPEGALQNNDGLYDPDCDESGLFKAKQCNGTSMCWCVNTAGVRRTDKDTEITCSERVRTYWIIIELKHKAREKPYDSKSLRTALQKEITTRYQLDPKFITSILYENNVITIDLVQNSSQKTQNDVDIADVAYYFEKDVKGESLFHSKKMDLTVNGEQLDLDPGQTLIYYVDEKAPEFSMQGLKAGVIAVIVVVVIAVVAGIVVLVISRKKRMAKYEKAEIKEMGEMHRELNA

Target ORF information:

RefSeq Version	NM_002354.2
Organism	Homo sapiens(human)
Definition	Homo sapiens epithelial cell adhesion molecule (EPCAM), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002354.2

ORF Insert Sequence:

ATGGCGCCCC CGCAGGTCCT CGCGTTCGGG CTTCTGCTTG CCGCGGCGAC GGCGACTTTT 
GCCGCAGCTC AGGAAGAATG TGTCTGTGAA AACTACAAGC TGGCCGTAAA CTGCTTTGTG 
AATAATAATC GTCAATGCCA GTGTACTTCA GTTGGTGCAC AAAATACTGT CATTTGCTCA 
AAGCTGGCTG CCAAATGTTT GGTGATGAAG GCAGAAATGA ATGGCTCAAA ACTTGGGAGA 
AGAGCAAAAC CTGAAGGGGC CCTCCAGAAC AATGATGGGC TTTATGATCC TGACTGCGAT 
GAGAGCGGGC TCTTTAAGGC CAAGCAGTGC AACGGCACCT CCATGTGCTG GTGTGTGAAC 
ACTGCTGGGG TCAGAAGAAC AGACAAGGAC ACTGAAATAA CCTGCTCTGA GCGAGTGAGA 
ACCTACTGGA TCATCATTGA ACTAAAACAC AAAGCAAGAG AAAAACCTTA TGATAGTAAA 
AGTTTGCGGA CTGCACTTCA GAAGGAGATC ACAACGCGTT ATCAACTGGA TCCAAAATTT 
ATCACGAGTA TTTTGTATGA GAATAATGTT ATCACTATTG ATCTGGTTCA AAATTCTTCT 
CAAAAAACTC AGAATGATGT GGACATAGCT GATGTGGCTT ATTATTTTGA AAAAGATGTT 
AAAGGTGAAT CCTTGTTTCA TTCTAAGAAA ATGGACCTGA CAGTAAATGG GGAACAACTG 
GATCTGGATC CTGGTCAAAC TTTAATTTAT TATGTTGATG AAAAAGCACC TGAATTCTCA 
ATGCAGGGTC TAAAAGCTGG TGTTATTGCT GTTATTGTGG TTGTGGTGAT AGCAGTTGTT 
GCTGGAATTG TTGTGCTGGT TATTTCCAGA AAGAAGAGAA TGGCAAAGTA TGAGAAGGCT 
GAGATAAAGG AGATGGGTGA GATGCATAGG GAACTCAATG CATAA