CD180 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CD180
Entrez Gene ID	4064
Full Name	CD180 molecule
Synonyms	LY64,Ly78,RP105
General protein information	Preferred Names CD180 molecule Names CD180 antigen lymphocyte antigen 64 lymphocyte antigen-64, radioprotective, 105kDa radioprotective 105 kDa protein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 5 Map Location: 5q12.3
Summary	CD180 is a cell surface molecule consisting of extracellular leucine-rich repeats (LRR) and a short cytoplasmic tail. The extracellular LRR is associated with a molecule called MD-1 and form the cell surface receptor complex, RP105/MD-1. It belongs to the family of pathogen receptors, Toll-like receptors (TLR). RP105/MD1, by working in concert with TLR4, controls B cell recognition and signaling of lipopolysaccharide (LPS), a membrane constituent of Gram-negative bacteria. [provided by RefSeq, Jul 2008].
Disorder MIM:	602226

mRNA and Protein(s)

mRNA	Protein	Name
XM_005248504.4	XP_005248561.1	CD180 antigen isoform X1
NM_005582.2	NP_005573.2	CD180 antigen precursor
NM_005582.3	NP_005573.2	CD180 antigen precursor

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Cd180	NP_001099875.1
Danio rerio (zebrafish)	LOC101885327	XP_005165726.1
Danio rerio (zebrafish)	LOC101884922	XP_005165722.1
Xenopus tropicalis (tropical clawed frog)	cd180	XP_004921501.1
	CD180	XP_002808476.1
Mus musculus (house mouse)	Cd180	NP_032559.2
Gallus gallus (chicken)	CD180	XP_004937367.1
Homo sapiens (human)	CD180	NP_005573.2
Pan troglodytes (chimpanzee)	CD180	XP_527202.2
Canis lupus familiaris (dog)	CD180	XP_544362.2
Bos taurus (cattle)	CD180	NP_001069636.1

Gene Ontology
Bibliography

Related articles in PubMed

CD150 and CD180 are involved in regulation of transcription factors expression in chronic lymphocytic leukemia cells.
Gordiienko I, Shlapatska L, Kholodniuk VM, Kovalevska L, Ivanivskaya TS, Sidorenko SP
Experimental oncology39(4)291-298(2017 Dec)

Calcitriol regulates immune genes
Longtine MS, Cvitic S, Colvin BN, Chen B, Desoye G, Nelson DM
Reproduction (Cambridge, England)154(6)735-744(2017 Dec)

Identification of CCR2 and CD180 as Robust Pharmacodynamic Tumor and Blood Biomarkers for Clinical Use with BRD4/BET Inhibitors.
Yeh TC, O'Connor G, Petteruti P, Dulak A, Hattersley M, Barrett JC, Chen H
Clinical cancer research : an official journal of the American Association for Cancer Research23(4)1025-1035(2017 Feb)

The interplay of CD150 and CD180 receptor pathways contribute to the pathobiology of chronic lymphocytic leukemia B cells by selective inhibition of Akt and MAPK signaling.
Gordiienko I, Shlapatska L, Kholodniuk V, Sklyarenko L, Gluzman DF, Clark EA, Sidorenko SP
PloS one12(10)e0185940(2017)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

CD180 expression is significantly upregulated in human masticatory mucosa during wound healing
Title: Human gingiva transcriptome during wound healing.

the close association between the increased proportion of CD180-negative B cells and the activation of IFN-alpha signaling in Systemic lupus erythematosus, is reported.
Title: Ligation of CD180 inhibits IFN-? signaling in a Lyn-PI3K-BTK-dependent manner in B cells.

combination of signals via CD150 and CD180 leads to blocking of pro-survival pathways that may be a restraining factor for neoplastic CLL B cells propagation in more than 50% of CLL cases where these receptors are coexpressed
Title: The interplay of CD150 and CD180 receptor pathways contribute to the pathobiology of chronic lymphocytic leukemia B cells by selective inhibition of Akt and MAPK signaling.

Since MEC1 cells are derived from a CLL patient with mutated IGVH genes (M-CLL) negative correlation between CD180 and CD32 expression on cycling MEC1 cells could be limited to M-CLL.
Title: Correlation of the expression of CD32 and CD180 receptors on CLL cells and MEC1 cell line.

By associating with PIM-1L, CD180 can thus obtain autonomous signaling capabilities, and this complex is then channeling inflammatory signals into B cell survival programs
Title: Human CD180 Transmits Signals via the PIM-1L Kinase.

The following CD180 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CD180 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu05077	NM_005582.3 Latest version!	Homo sapiens CD180 molecule (CD180), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$265.30 $379.00
OHu39576	XM_005248504.4 Latest version!	Homo sapiens CD180 molecule (CD180), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00
View Old Accession Versions >>
OHu05077	NM_005582.2	Homo sapiens CD180 molecule (CD180), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$265.30 $379.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CD180 ( NM_005582.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_005573.2 Homo sapiens CD180 molecule (CD180), mRNA.

Price & Availability↑

CloneID	OHu05077
Clone ID Related Accession (Same CDS sequence)	NM_005582.2 , NM_005582.3
Accession Version	NM_005582.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1986bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-11-11
Organism	Homo sapiens(human)
Product	CD180 antigen precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL544501.3, BP344300.1, BC109069.1, AL570708.3 and AW512119.1. On Feb 9, 2008 this sequence version replaced NM_005582.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163658.407686.1, D83597.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGTTTG ACGTCAGCTG CTTCTTTTGG GTGGTGCTGT TTTCTGCCGG CTGTAAAGTC 
ATCACCTCCT GGGATCAGAT GTGCATTGAG AAAGAAGCCA ACAAAACATA TAACTGTGAA 
AATTTAGGTC TCAGTGAAAT CCCTGACACT CTACCAAACA CAACAGAATT TTTGGAATTC 
AGCTTTAATT TTTTGCCTAC AATTCACAAT AGAACCTTCA GCAGACTCAT GAATCTTACC 
TTTTTGGATT TAACTAGGTG CCAGATTAAC TGGATACATG AAGACACTTT TCAAAGCCAT 
CATCAATTAA GCACACTTGT GTTAACTGGA AATCCCCTGA TATTCATGGC AGAAACATCG 
CTTAATGGGC CCAAGTCACT GAAGCATCTT TTCTTAATCC AAACGGGAAT ATCCAATCTC 
GAGTTTATTC CAGTGCACAA TCTGGAAAAC TTGGAAAGCT TGTATCTTGG AAGCAACCAT 
ATTTCCTCCA TTAAGTTCCC CAAAGACTTC CCAGCACGGA ATCTGAAAGT ACTGGATTTT 
CAGAATAATG CTATACACTA CATCTCTAGA GAAGACATGA GGTCTCTGGA GCAGGCCATC 
AACCTAAGCC TGAACTTCAA TGGCAATAAT GTTAAAGGTA TTGAGCTTGG GGCTTTTGAT 
TCAACGATCT TCCAAAGTTT GAACTTTGGA GGAACTCCAA ATTTGTCTGT TATATTCAAT 
GGTCTGCAGA ACTCTACTAC TCAGTCTCTC TGGCTGGGAA CATTTGAGGA CATTGATGAC 
GAAGATATTA GTTCAGCCAT GCTCAAGGGA CTCTGTGAAA TGTCTGTTGA GAGCCTCAAC 
CTGCAGGAAC ACCGCTTCTC TGACATCTCA TCCACCACAT TTCAGTGCTT CACCCAACTC 
CAAGAATTGG ATCTGACAGC AACTCACTTG AAAGGGTTAC CCTCTGGGAT GAAGGGTCTG 
AACTTGCTCA AGAAATTAGT TCTCAGTGTA AATCATTTCG ATCAATTGTG TCAAATCAGT 
GCTGCCAATT TCCCCTCCCT TACACACCTC TACATCAGAG GCAACGTGAA GAAACTTCAC 
CTTGGTGTTG GCTGCTTGGA GAAACTAGGA AACCTTCAGA CACTTGATTT AAGCCATAAT 
GACATAGAGG CTTCTGACTG CTGCAGTCTG CAACTCAAAA ACCTGTCCCA CTTGCAAACC 
TTAAACCTGA GCCACAATGA GCCTCTTGGT CTCCAGAGTC AGGCATTCAA AGAATGTCCT 
CAGCTAGAAC TCCTCGATTT GGCATTTACC CGCTTACACA TTAATGCTCC ACAAAGTCCC 
TTCCAAAACC TCCATTTCCT TCAGGTTCTG AATCTCACTT ACTGCTTCCT TGATACCAGC 
AATCAGCATC TTCTAGCAGG CCTACCAGTT CTCCGGCATC TCAACTTAAA AGGGAATCAC 
TTTCAAGATG GGACTATCAC GAAGACCAAC CTACTTCAGA CCGTGGGCAG CTTGGAGGTT 
CTGATTTTGT CCTCTTGTGG TCTCCTCTCT ATAGACCAGC AAGCATTCCA CAGCTTGGGA 
AAAATGAGCC ATGTAGACTT AAGCCACAAC AGCCTGACAT GCGACAGCAT TGATTCTCTT 
AGCCATCTTA AGGGAATCTA CCTCAATCTG GCTGCCAACA GCATTAACAT CATCTCACCC 
CGTCTCCTCC CTATCTTGTC CCAGCAGAGC ACCATTAATT TAAGTCATAA CCCCCTGGAC 
TGCACTTGCT CGAATATTCA TTTCTTAACA TGGTACAAAG AAAACCTGCA CAAACTTGAA 
GGCTCGGAGG AGACCACGTG TGCAAACCCG CCATCTCTAA GGGGAGTTAA GCTATCTGAT 
GTCAAGCTTT CCTGTGGGAT TACAGCCATA GGCATTTTCT TTCTCATAGT ATTTCTATTA 
TTGTTGGCTA TTCTGCTATT TTTTGCAGTT AAATACCTTC TCAGGTGGAA ATACCAACAC 
ATTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005573.2
CDS	149..2134
Translation	MAFDVSCFFWVVLFSAGCKVITSWDQMCIEKEANKTYNCENLGLSEIPDTLPNTTEFLEFSFNFLPTIHNRTFSRLMNLTFLDLTRCQINWIHEDTFQSHHQLSTLVLTGNPLIFMAETSLNGPKSLKHLFLIQTGISNLEFIPVHNLENLESLYLGSNHISSIKFPKDFPARNLKVLDFQNNAIHYISREDMRSLEQAINLSLNFNGNNVKGIELGAFDSTIFQSLNFGGTPNLSVIFNGLQNSTTQSLWLGTFEDIDDEDISSAMLKGLCEMSVESLNLQEHRFSDISSTTFQCFTQLQELDLTATHLKGLPSGMKGLNLLKKLVLSVNHFDQLCQISAANFPSLTHLYIRGNVKKLHLGVGCLEKLGNLQTLDLSHNDIEASDCCSLQLKNLSHLQTLNLSHNEPLGLQSQAFKECPQLELLDLAFTRLHINAPQSPFQNLHFLQVLNLTYCFLDTSNQHLLAGLPVLRHLNLKGNHFQDGTITKTNLLQTVGSLEVLILSSCGLLSIDQQAFHSLGKMSHVDLSHNSLTCDSIDSLSHLKGIYLNLAANSINIISPRLLPILSQQSTINLSHNPLDCTCSNIHFLTWYKENLHKLEGSEETTCANPPSLRGVKLSDVKLSCGITAIGIFFLIVFLLLLAILLFFAVKYLLRWKYQHI

Target ORF information:

RefSeq Version	NM_005582.2
Organism	Homo sapiens(human)
Definition	Homo sapiens CD180 molecule (CD180), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005582.2

ORF Insert Sequence:

ATGGCGTTTG ACGTCAGCTG CTTCTTTTGG GTGGTGCTGT TTTCTGCCGG CTGTAAAGTC 
ATCACCTCCT GGGATCAGAT GTGCATTGAG AAAGAAGCCA ACAAAACATA TAACTGTGAA 
AATTTAGGTC TCAGTGAAAT CCCTGACACT CTACCAAACA CAACAGAATT TTTGGAATTC 
AGCTTTAATT TTTTGCCTAC AATTCACAAT AGAACCTTCA GCAGACTCAT GAATCTTACC 
TTTTTGGATT TAACTAGGTG CCAGATTAAC TGGATACATG AAGACACTTT TCAAAGCCAT 
CATCAATTAA GCACACTTGT GTTAACTGGA AATCCCCTGA TATTCATGGC AGAAACATCG 
CTTAATGGGC CCAAGTCACT GAAGCATCTT TTCTTAATCC AAACGGGAAT ATCCAATCTC 
GAGTTTATTC CAGTGCACAA TCTGGAAAAC TTGGAAAGCT TGTATCTTGG AAGCAACCAT 
ATTTCCTCCA TTAAGTTCCC CAAAGACTTC CCAGCACGGA ATCTGAAAGT ACTGGATTTT 
CAGAATAATG CTATACACTA CATCTCTAGA GAAGACATGA GGTCTCTGGA GCAGGCCATC 
AACCTAAGCC TGAACTTCAA TGGCAATAAT GTTAAAGGTA TTGAGCTTGG GGCTTTTGAT 
TCAACGATCT TCCAAAGTTT GAACTTTGGA GGAACTCCAA ATTTGTCTGT TATATTCAAT 
GGTCTGCAGA ACTCTACTAC TCAGTCTCTC TGGCTGGGAA CATTTGAGGA CATTGATGAC 
GAAGATATTA GTTCAGCCAT GCTCAAGGGA CTCTGTGAAA TGTCTGTTGA GAGCCTCAAC 
CTGCAGGAAC ACCGCTTCTC TGACATCTCA TCCACCACAT TTCAGTGCTT CACCCAACTC 
CAAGAATTGG ATCTGACAGC AACTCACTTG AAAGGGTTAC CCTCTGGGAT GAAGGGTCTG 
AACTTGCTCA AGAAATTAGT TCTCAGTGTA AATCATTTCG ATCAATTGTG TCAAATCAGT 
GCTGCCAATT TCCCCTCCCT TACACACCTC TACATCAGAG GCAACGTGAA GAAACTTCAC 
CTTGGTGTTG GCTGCTTGGA GAAACTAGGA AACCTTCAGA CACTTGATTT AAGCCATAAT 
GACATAGAGG CTTCTGACTG CTGCAGTCTG CAACTCAAAA ACCTGTCCCA CTTGCAAACC 
TTAAACCTGA GCCACAATGA GCCTCTTGGT CTCCAGAGTC AGGCATTCAA AGAATGTCCT 
CAGCTAGAAC TCCTCGATTT GGCATTTACC CGCTTACACA TTAATGCTCC ACAAAGTCCC 
TTCCAAAACC TCCATTTCCT TCAGGTTCTG AATCTCACTT ACTGCTTCCT TGATACCAGC 
AATCAGCATC TTCTAGCAGG CCTACCAGTT CTCCGGCATC TCAACTTAAA AGGGAATCAC 
TTTCAAGATG GGACTATCAC GAAGACCAAC CTACTTCAGA CCGTGGGCAG CTTGGAGGTT 
CTGATTTTGT CCTCTTGTGG TCTCCTCTCT ATAGACCAGC AAGCATTCCA CAGCTTGGGA 
AAAATGAGCC ATGTAGACTT AAGCCACAAC AGCCTGACAT GCGACAGCAT TGATTCTCTT 
AGCCATCTTA AGGGAATCTA CCTCAATCTG GCTGCCAACA GCATTAACAT CATCTCACCC 
CGTCTCCTCC CTATCTTGTC CCAGCAGAGC ACCATTAATT TAAGTCATAA CCCCCTGGAC 
TGCACTTGCT CGAATATTCA TTTCTTAACA TGGTACAAAG AAAACCTGCA CAAACTTGAA 
GGCTCGGAGG AGACCACGTG TGCAAACCCG CCATCTCTAA GGGGAGTTAA GCTATCTGAT 
GTCAAGCTTT CCTGTGGGAT TACAGCCATA GGCATTTTCT TTCTCATAGT ATTTCTATTA 
TTGTTGGCTA TTCTGCTATT TTTTGCAGTT AAATACCTTC TCAGGTGGAA ATACCAACAC 
ATTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CD180 ( NM_005582.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_005573.2 Homo sapiens CD180 molecule (CD180), mRNA.

Price & Availability↑

CloneID	OHu05077
Clone ID Related Accession (Same CDS sequence)	NM_005582.2 , NM_005582.3
Accession Version	NM_005582.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1986bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-06
Organism	Homo sapiens(human)
Product	CD180 antigen precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC026445.5, AL544501.3, BP344300.1, BC109069.1, AL570708.3 and AW512119.1. On Nov 23, 2018 this sequence version replaced NM_005582.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK313177.1, D83597.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000256447.5/ ENSP00000256447.4 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCGTTTG ACGTCAGCTG CTTCTTTTGG GTGGTGCTGT TTTCTGCCGG CTGTAAAGTC 
ATCACCTCCT GGGATCAGAT GTGCATTGAG AAAGAAGCCA ACAAAACATA TAACTGTGAA 
AATTTAGGTC TCAGTGAAAT CCCTGACACT CTACCAAACA CAACAGAATT TTTGGAATTC 
AGCTTTAATT TTTTGCCTAC AATTCACAAT AGAACCTTCA GCAGACTCAT GAATCTTACC 
TTTTTGGATT TAACTAGGTG CCAGATTAAC TGGATACATG AAGACACTTT TCAAAGCCAT 
CATCAATTAA GCACACTTGT GTTAACTGGA AATCCCCTGA TATTCATGGC AGAAACATCG 
CTTAATGGGC CCAAGTCACT GAAGCATCTT TTCTTAATCC AAACGGGAAT ATCCAATCTC 
GAGTTTATTC CAGTGCACAA TCTGGAAAAC TTGGAAAGCT TGTATCTTGG AAGCAACCAT 
ATTTCCTCCA TTAAGTTCCC CAAAGACTTC CCAGCACGGA ATCTGAAAGT ACTGGATTTT 
CAGAATAATG CTATACACTA CATCTCTAGA GAAGACATGA GGTCTCTGGA GCAGGCCATC 
AACCTAAGCC TGAACTTCAA TGGCAATAAT GTTAAAGGTA TTGAGCTTGG GGCTTTTGAT 
TCAACGATCT TCCAAAGTTT GAACTTTGGA GGAACTCCAA ATTTGTCTGT TATATTCAAT 
GGTCTGCAGA ACTCTACTAC TCAGTCTCTC TGGCTGGGAA CATTTGAGGA CATTGATGAC 
GAAGATATTA GTTCAGCCAT GCTCAAGGGA CTCTGTGAAA TGTCTGTTGA GAGCCTCAAC 
CTGCAGGAAC ACCGCTTCTC TGACATCTCA TCCACCACAT TTCAGTGCTT CACCCAACTC 
CAAGAATTGG ATCTGACAGC AACTCACTTG AAAGGGTTAC CCTCTGGGAT GAAGGGTCTG 
AACTTGCTCA AGAAATTAGT TCTCAGTGTA AATCATTTCG ATCAATTGTG TCAAATCAGT 
GCTGCCAATT TCCCCTCCCT TACACACCTC TACATCAGAG GCAACGTGAA GAAACTTCAC 
CTTGGTGTTG GCTGCTTGGA GAAACTAGGA AACCTTCAGA CACTTGATTT AAGCCATAAT 
GACATAGAGG CTTCTGACTG CTGCAGTCTG CAACTCAAAA ACCTGTCCCA CTTGCAAACC 
TTAAACCTGA GCCACAATGA GCCTCTTGGT CTCCAGAGTC AGGCATTCAA AGAATGTCCT 
CAGCTAGAAC TCCTCGATTT GGCATTTACC CGCTTACACA TTAATGCTCC ACAAAGTCCC 
TTCCAAAACC TCCATTTCCT TCAGGTTCTG AATCTCACTT ACTGCTTCCT TGATACCAGC 
AATCAGCATC TTCTAGCAGG CCTACCAGTT CTCCGGCATC TCAACTTAAA AGGGAATCAC 
TTTCAAGATG GGACTATCAC GAAGACCAAC CTACTTCAGA CCGTGGGCAG CTTGGAGGTT 
CTGATTTTGT CCTCTTGTGG TCTCCTCTCT ATAGACCAGC AAGCATTCCA CAGCTTGGGA 
AAAATGAGCC ATGTAGACTT AAGCCACAAC AGCCTGACAT GCGACAGCAT TGATTCTCTT 
AGCCATCTTA AGGGAATCTA CCTCAATCTG GCTGCCAACA GCATTAACAT CATCTCACCC 
CGTCTCCTCC CTATCTTGTC CCAGCAGAGC ACCATTAATT TAAGTCATAA CCCCCTGGAC 
TGCACTTGCT CGAATATTCA TTTCTTAACA TGGTACAAAG AAAACCTGCA CAAACTTGAA 
GGCTCGGAGG AGACCACGTG TGCAAACCCG CCATCTCTAA GGGGAGTTAA GCTATCTGAT 
GTCAAGCTTT CCTGTGGGAT TACAGCCATA GGCATTTTCT TTCTCATAGT ATTTCTATTA 
TTGTTGGCTA TTCTGCTATT TTTTGCAGTT AAATACCTTC TCAGGTGGAA ATACCAACAC 
ATTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005573.2
CDS	159..2144
Translation	MAFDVSCFFWVVLFSAGCKVITSWDQMCIEKEANKTYNCENLGLSEIPDTLPNTTEFLEFSFNFLPTIHNRTFSRLMNLTFLDLTRCQINWIHEDTFQSHHQLSTLVLTGNPLIFMAETSLNGPKSLKHLFLIQTGISNLEFIPVHNLENLESLYLGSNHISSIKFPKDFPARNLKVLDFQNNAIHYISREDMRSLEQAINLSLNFNGNNVKGIELGAFDSTIFQSLNFGGTPNLSVIFNGLQNSTTQSLWLGTFEDIDDEDISSAMLKGLCEMSVESLNLQEHRFSDISSTTFQCFTQLQELDLTATHLKGLPSGMKGLNLLKKLVLSVNHFDQLCQISAANFPSLTHLYIRGNVKKLHLGVGCLEKLGNLQTLDLSHNDIEASDCCSLQLKNLSHLQTLNLSHNEPLGLQSQAFKECPQLELLDLAFTRLHINAPQSPFQNLHFLQVLNLTYCFLDTSNQHLLAGLPVLRHLNLKGNHFQDGTITKTNLLQTVGSLEVLILSSCGLLSIDQQAFHSLGKMSHVDLSHNSLTCDSIDSLSHLKGIYLNLAANSINIISPRLLPILSQQSTINLSHNPLDCTCSNIHFLTWYKENLHKLEGSEETTCANPPSLRGVKLSDVKLSCGITAIGIFFLIVFLLLLAILLFFAVKYLLRWKYQHI

Target ORF information:

RefSeq Version	NM_005582.3
Organism	Homo sapiens(human)
Definition	Homo sapiens CD180 molecule (CD180), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005582.3

ORF Insert Sequence:

ATGGCGTTTG ACGTCAGCTG CTTCTTTTGG GTGGTGCTGT TTTCTGCCGG CTGTAAAGTC 
ATCACCTCCT GGGATCAGAT GTGCATTGAG AAAGAAGCCA ACAAAACATA TAACTGTGAA 
AATTTAGGTC TCAGTGAAAT CCCTGACACT CTACCAAACA CAACAGAATT TTTGGAATTC 
AGCTTTAATT TTTTGCCTAC AATTCACAAT AGAACCTTCA GCAGACTCAT GAATCTTACC 
TTTTTGGATT TAACTAGGTG CCAGATTAAC TGGATACATG AAGACACTTT TCAAAGCCAT 
CATCAATTAA GCACACTTGT GTTAACTGGA AATCCCCTGA TATTCATGGC AGAAACATCG 
CTTAATGGGC CCAAGTCACT GAAGCATCTT TTCTTAATCC AAACGGGAAT ATCCAATCTC 
GAGTTTATTC CAGTGCACAA TCTGGAAAAC TTGGAAAGCT TGTATCTTGG AAGCAACCAT 
ATTTCCTCCA TTAAGTTCCC CAAAGACTTC CCAGCACGGA ATCTGAAAGT ACTGGATTTT 
CAGAATAATG CTATACACTA CATCTCTAGA GAAGACATGA GGTCTCTGGA GCAGGCCATC 
AACCTAAGCC TGAACTTCAA TGGCAATAAT GTTAAAGGTA TTGAGCTTGG GGCTTTTGAT 
TCAACGATCT TCCAAAGTTT GAACTTTGGA GGAACTCCAA ATTTGTCTGT TATATTCAAT 
GGTCTGCAGA ACTCTACTAC TCAGTCTCTC TGGCTGGGAA CATTTGAGGA CATTGATGAC 
GAAGATATTA GTTCAGCCAT GCTCAAGGGA CTCTGTGAAA TGTCTGTTGA GAGCCTCAAC 
CTGCAGGAAC ACCGCTTCTC TGACATCTCA TCCACCACAT TTCAGTGCTT CACCCAACTC 
CAAGAATTGG ATCTGACAGC AACTCACTTG AAAGGGTTAC CCTCTGGGAT GAAGGGTCTG 
AACTTGCTCA AGAAATTAGT TCTCAGTGTA AATCATTTCG ATCAATTGTG TCAAATCAGT 
GCTGCCAATT TCCCCTCCCT TACACACCTC TACATCAGAG GCAACGTGAA GAAACTTCAC 
CTTGGTGTTG GCTGCTTGGA GAAACTAGGA AACCTTCAGA CACTTGATTT AAGCCATAAT 
GACATAGAGG CTTCTGACTG CTGCAGTCTG CAACTCAAAA ACCTGTCCCA CTTGCAAACC 
TTAAACCTGA GCCACAATGA GCCTCTTGGT CTCCAGAGTC AGGCATTCAA AGAATGTCCT 
CAGCTAGAAC TCCTCGATTT GGCATTTACC CGCTTACACA TTAATGCTCC ACAAAGTCCC 
TTCCAAAACC TCCATTTCCT TCAGGTTCTG AATCTCACTT ACTGCTTCCT TGATACCAGC 
AATCAGCATC TTCTAGCAGG CCTACCAGTT CTCCGGCATC TCAACTTAAA AGGGAATCAC 
TTTCAAGATG GGACTATCAC GAAGACCAAC CTACTTCAGA CCGTGGGCAG CTTGGAGGTT 
CTGATTTTGT CCTCTTGTGG TCTCCTCTCT ATAGACCAGC AAGCATTCCA CAGCTTGGGA 
AAAATGAGCC ATGTAGACTT AAGCCACAAC AGCCTGACAT GCGACAGCAT TGATTCTCTT 
AGCCATCTTA AGGGAATCTA CCTCAATCTG GCTGCCAACA GCATTAACAT CATCTCACCC 
CGTCTCCTCC CTATCTTGTC CCAGCAGAGC ACCATTAATT TAAGTCATAA CCCCCTGGAC 
TGCACTTGCT CGAATATTCA TTTCTTAACA TGGTACAAAG AAAACCTGCA CAAACTTGAA 
GGCTCGGAGG AGACCACGTG TGCAAACCCG CCATCTCTAA GGGGAGTTAA GCTATCTGAT 
GTCAAGCTTT CCTGTGGGAT TACAGCCATA GGCATTTTCT TTCTCATAGT ATTTCTATTA 
TTGTTGGCTA TTCTGCTATT TTTTGCAGTT AAATACCTTC TCAGGTGGAA ATACCAACAC 
ATTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CD180 ( XM_005248504.4 ) cDNA ORF clone, Homo sapiens(human) -> XP_005248561.1 Homo sapiens CD180 molecule (CD180), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu39576
Clone ID Related Accession (Same CDS sequence)	XM_005248504.4
Accession Version	XM_005248504.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1947bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	CD180 antigen isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000005.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_005248504.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGGGAGGT GGCTGCTGCG TGTGTCAAGC GCAGATGAGA AATCCGAAAA GAAAGAAGCC 
AACAAAACAT ATAACTGTGA AAATTTAGGT CTCAGTGAAA TCCCTGACAC TCTACCAAAC 
ACAACAGAAT TTTTGGAATT CAGCTTTAAT TTTTTGCCTA CAATTCACAA TAGAACCTTC 
AGCAGACTCA TGAATCTTAC CTTTTTGGAT TTAACTAGGT GCCAGATTAA CTGGATACAT 
GAAGACACTT TTCAAAGCCA TCATCAATTA AGCACACTTG TGTTAACTGG AAATCCCCTG 
ATATTCATGG CAGAAACATC GCTTAATGGG CCCAAGTCAC TGAAGCATCT TTTCTTAATC 
CAAACGGGAA TATCCAATCT CGAGTTTATT CCAGTGCACA ATCTGGAAAA CTTGGAAAGC 
TTGTATCTTG GAAGCAACCA TATTTCCTCC ATTAAGTTCC CCAAAGACTT CCCAGCACGG 
AATCTGAAAG TACTGGATTT TCAGAATAAT GCTATACACT ACATCTCTAG AGAAGACATG 
AGGTCTCTGG AGCAGGCCAT CAACCTAAGC CTGAACTTCA ATGGCAATAA TGTTAAAGGT 
ATTGAGCTTG GGGCTTTTGA TTCAACGATC TTCCAAAGTT TGAACTTTGG AGGAACTCCA 
AATTTGTCTG TTATATTCAA TGGTCTGCAG AACTCTACTA CTCAGTCTCT CTGGCTGGGA 
ACATTTGAGG ACATTGATGA CGAAGATATT AGTTCAGCCA TGCTCAAGGG ACTCTGTGAA 
ATGTCTGTTG AGAGCCTCAA CCTGCAGGAA CACCGCTTCT CTGACATCTC ATCCACCACA 
TTTCAGTGCT TCACCCAACT CCAAGAATTG GATCTGACAG CAACTCACTT GAAAGGGTTA 
CCCTCTGGGA TGAAGGGTCT GAACTTGCTC AAGAAATTAG TTCTCAGTGT AAATCATTTC 
GATCAATTGT GTCAAATCAG TGCTGCCAAT TTCCCCTCCC TTACACACCT CTACATCAGA 
GGCAACGTGA AGAAACTTCA CCTTGGTGTT GGCTGCTTGG AGAAACTAGG AAACCTTCAG 
ACACTTGATT TAAGCCATAA TGACATAGAG GCTTCTGACT GCTGCAGTCT GCAACTCAAA 
AACCTGTCCC ACTTGCAAAC CTTAAACCTG AGCCACAATG AGCCTCTTGG TCTCCAGAGT 
CAGGCATTCA AAGAATGTCC TCAGCTAGAA CTCCTCGATT TGGCATTTAC CCGCTTACAC 
ATTAATGCTC CACAAAGTCC CTTCCAAAAC CTCCATTTCC TTCAGGTTCT GAATCTCACT 
TACTGCTTCC TTGATACCAG CAATCAGCAT CTTCTAGCAG GCCTACCAGT TCTCCGGCAT 
CTCAACTTAA AAGGGAATCA CTTTCAAGAT GGGACTATCA CGAAGACCAA CCTACTTCAG 
ACCGTGGGCA GCTTGGAGGT TCTGATTTTG TCCTCTTGTG GTCTCCTCTC TATAGACCAG 
CAAGCATTCC ACAGCTTGGG AAAAATGAGC CATGTAGACT TAAGCCACAA CAGCCTGACA 
TGCGACAGCA TTGATTCTCT TAGCCATCTT AAGGGAATCT ACCTCAATCT GGCTGCCAAC 
AGCATTAACA TCATCTCACC CCGTCTCCTC CCTATCTTGT CCCAGCAGAG CACCATTAAT 
TTAAGTCATA ACCCCCTGGA CTGCACTTGC TCGAATATTC ATTTCTTAAC ATGGTACAAA 
GAAAACCTGC ACAAACTTGA AGGCTCGGAG GAGACCACGT GTGCAAACCC GCCATCTCTA 
AGGGGAGTTA AGCTATCTGA TGTCAAGCTT TCCTGTGGGA TTACAGCCAT AGGCATTTTC 
TTTCTCATAG TATTTCTATT ATTGTTGGCT ATTCTGCTAT TTTTTGCAGT TAAATACCTT 
CTCAGGTGGA AATACCAACA CATTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005248561.1
CDS	197..2143
Translation	MGRWLLRVSSADEKSEKKEANKTYNCENLGLSEIPDTLPNTTEFLEFSFNFLPTIHNRTFSRLMNLTFLDLTRCQINWIHEDTFQSHHQLSTLVLTGNPLIFMAETSLNGPKSLKHLFLIQTGISNLEFIPVHNLENLESLYLGSNHISSIKFPKDFPARNLKVLDFQNNAIHYISREDMRSLEQAINLSLNFNGNNVKGIELGAFDSTIFQSLNFGGTPNLSVIFNGLQNSTTQSLWLGTFEDIDDEDISSAMLKGLCEMSVESLNLQEHRFSDISSTTFQCFTQLQELDLTATHLKGLPSGMKGLNLLKKLVLSVNHFDQLCQISAANFPSLTHLYIRGNVKKLHLGVGCLEKLGNLQTLDLSHNDIEASDCCSLQLKNLSHLQTLNLSHNEPLGLQSQAFKECPQLELLDLAFTRLHINAPQSPFQNLHFLQVLNLTYCFLDTSNQHLLAGLPVLRHLNLKGNHFQDGTITKTNLLQTVGSLEVLILSSCGLLSIDQQAFHSLGKMSHVDLSHNSLTCDSIDSLSHLKGIYLNLAANSINIISPRLLPILSQQSTINLSHNPLDCTCSNIHFLTWYKENLHKLEGSEETTCANPPSLRGVKLSDVKLSCGITAIGIFFLIVFLLLLAILLFFAVKYLLRWKYQHI

Target ORF information:

RefSeq Version	XM_005248504.4
Organism	Homo sapiens(human)
Definition	Homo sapiens CD180 molecule (CD180), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005248504.4

ORF Insert Sequence:

ATGGGGAGGT GGCTGCTGCG TGTGTCAAGC GCAGATGAGA AATCCGAAAA GAAAGAAGCC 
AACAAAACAT ATAACTGTGA AAATTTAGGT CTCAGTGAAA TCCCTGACAC TCTACCAAAC 
ACAACAGAAT TTTTGGAATT CAGCTTTAAT TTTTTGCCTA CAATTCACAA TAGAACCTTC 
AGCAGACTCA TGAATCTTAC CTTTTTGGAT TTAACTAGGT GCCAGATTAA CTGGATACAT 
GAAGACACTT TTCAAAGCCA TCATCAATTA AGCACACTTG TGTTAACTGG AAATCCCCTG 
ATATTCATGG CAGAAACATC GCTTAATGGG CCCAAGTCAC TGAAGCATCT TTTCTTAATC 
CAAACGGGAA TATCCAATCT CGAGTTTATT CCAGTGCACA ATCTGGAAAA CTTGGAAAGC 
TTGTATCTTG GAAGCAACCA TATTTCCTCC ATTAAGTTCC CCAAAGACTT CCCAGCACGG 
AATCTGAAAG TACTGGATTT TCAGAATAAT GCTATACACT ACATCTCTAG AGAAGACATG 
AGGTCTCTGG AGCAGGCCAT CAACCTAAGC CTGAACTTCA ATGGCAATAA TGTTAAAGGT 
ATTGAGCTTG GGGCTTTTGA TTCAACGATC TTCCAAAGTT TGAACTTTGG AGGAACTCCA 
AATTTGTCTG TTATATTCAA TGGTCTGCAG AACTCTACTA CTCAGTCTCT CTGGCTGGGA 
ACATTTGAGG ACATTGATGA CGAAGATATT AGTTCAGCCA TGCTCAAGGG ACTCTGTGAA 
ATGTCTGTTG AGAGCCTCAA CCTGCAGGAA CACCGCTTCT CTGACATCTC ATCCACCACA 
TTTCAGTGCT TCACCCAACT CCAAGAATTG GATCTGACAG CAACTCACTT GAAAGGGTTA 
CCCTCTGGGA TGAAGGGTCT GAACTTGCTC AAGAAATTAG TTCTCAGTGT AAATCATTTC 
GATCAATTGT GTCAAATCAG TGCTGCCAAT TTCCCCTCCC TTACACACCT CTACATCAGA 
GGCAACGTGA AGAAACTTCA CCTTGGTGTT GGCTGCTTGG AGAAACTAGG AAACCTTCAG 
ACACTTGATT TAAGCCATAA TGACATAGAG GCTTCTGACT GCTGCAGTCT GCAACTCAAA 
AACCTGTCCC ACTTGCAAAC CTTAAACCTG AGCCACAATG AGCCTCTTGG TCTCCAGAGT 
CAGGCATTCA AAGAATGTCC TCAGCTAGAA CTCCTCGATT TGGCATTTAC CCGCTTACAC 
ATTAATGCTC CACAAAGTCC CTTCCAAAAC CTCCATTTCC TTCAGGTTCT GAATCTCACT 
TACTGCTTCC TTGATACCAG CAATCAGCAT CTTCTAGCAG GCCTACCAGT TCTCCGGCAT 
CTCAACTTAA AAGGGAATCA CTTTCAAGAT GGGACTATCA CGAAGACCAA CCTACTTCAG 
ACCGTGGGCA GCTTGGAGGT TCTGATTTTG TCCTCTTGTG GTCTCCTCTC TATAGACCAG 
CAAGCATTCC ACAGCTTGGG AAAAATGAGC CATGTAGACT TAAGCCACAA CAGCCTGACA 
TGCGACAGCA TTGATTCTCT TAGCCATCTT AAGGGAATCT ACCTCAATCT GGCTGCCAAC 
AGCATTAACA TCATCTCACC CCGTCTCCTC CCTATCTTGT CCCAGCAGAG CACCATTAAT 
TTAAGTCATA ACCCCCTGGA CTGCACTTGC TCGAATATTC ATTTCTTAAC ATGGTACAAA 
GAAAACCTGC ACAAACTTGA AGGCTCGGAG GAGACCACGT GTGCAAACCC GCCATCTCTA 
AGGGGAGTTA AGCTATCTGA TGTCAAGCTT TCCTGTGGGA TTACAGCCAT AGGCATTTTC 
TTTCTCATAG TATTTCTATT ATTGTTGGCT ATTCTGCTAT TTTTTGCAGT TAAATACCTT 
CTCAGGTGGA AATACCAACA CATTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

CD150 and CD180 are involved in regulation of transcription factors expression in chronic lymphocytic leukemia cells.
Experimental oncology39(4)291-298(2017 Dec)
Gordiienko I,Shlapatska L,Kholodniuk VM,Kovalevska L,Ivanivskaya TS,Sidorenko SP

Calcitriol regulates immune genes
Reproduction (Cambridge, England)154(6)735-744(2017 Dec)
Longtine MS,Cvitic S,Colvin BN,Chen B,Desoye G,Nelson DM

Identification of CCR2 and CD180 as Robust Pharmacodynamic Tumor and Blood Biomarkers for Clinical Use with BRD4/BET Inhibitors.
Clinical cancer research : an official journal of the American Association for Cancer Research23(4)1025-1035(2017 Feb)
Yeh TC,O'Connor G,Petteruti P,Dulak A,Hattersley M,Barrett JC,Chen H

The interplay of CD150 and CD180 receptor pathways contribute to the pathobiology of chronic lymphocytic leukemia B cells by selective inhibition of Akt and MAPK signaling.
PloS one12(10)e0185940(2017)
Gordiienko I,Shlapatska L,Kholodniuk V,Sklyarenko L,Gluzman DF,Clark EA,Sidorenko SP

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CD180 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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