ERVFRD-1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	ERVFRD-1
Entrez Gene ID	405754
Full Name	endogenous retrovirus group FRD member 1, envelope
Synonyms	ERVFRDE1,GLLL6191,HERV-FRD,HERV-W/FRD,UNQ6191,envFRD
General protein information	Preferred Names endogenous retrovirus group FRD member 1, envelope Names syncytin-2 HERV-FRD provirus ancestral Env polyprotein HERV-FRD_6p24.1 provirus ancestral Env polyprotein endogenous retrovirus group FRD member 1 envelope polyprotein syncytin 2
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 6 Map Location: 6p24.2
Summary	Many different human endogenous retrovirus (HERV) families are expressed in normal placental tissue at high levels, suggesting that HERVs are functionally important in reproduction. This gene is part of a human endogenous retrovirus provirus on chromosome 6 that has inactivating mutations in the gag and pol genes. This gene is the envelope glycoprotein gene which appears to have been selectively preserved. The gene's protein product plays a major role in placental development and trophoblast fusion. The protein has the characteristics of a typical retroviral envelope protein, including a cleavage site that separates the surface (SU) and transmembrane (TM) proteins which form a heterodimer. [provided by RefSeq, Jun 2012].
Disorder MIM:	610524

mRNA and Protein(s)

mRNA	Protein	Name
NM_207582.3	NP_997465.1	syncytin-2 preproprotein
NM_207582.2	NP_997465.1	syncytin-2 preproprotein

Pathways from BioSystems

Homologies

Homo sapiens (human)	ERVFRD-1	NP_997465.1
Mus musculus (house mouse)	Synb	NP_775596.1
	LOC100425316	XP_002803642.1
Pan troglodytes (chimpanzee)	ERVFRD-1	NP_001074253.1
Rattus norvegicus (Norway rat)	Ervfrd-1	NP_001019410.1

Gene Ontology
Bibliography

Related articles in PubMed

The role of syncytins in human reproduction and reproductive organ cancers.
Soygur B, Sati L
Reproduction (Cambridge, England)152(5)R167-78(2016 11)

Altered expression of human endogenous retroviruses syncytin-1, syncytin-2 and their receptors in human normal and gestational diabetic placenta.
Soygur B, Sati L, Demir R
Histology and histopathology31(9)1037-47(2016 Sep)

Effects of individually silenced N-glycosylation sites and non-synonymous single-nucleotide polymorphisms on the fusogenic function of human syncytin-2.
Cui L, Wang H, Lu X, Wang R, Zheng R, Li Y, Yang X, Jia WT, Zhao Y, Wang Y, Wang H, Wang YL, Zhu C, Lin HY, Wang H
Cell adhesion & migration10(1-2)39-55(2016 Mar)

Expression patterns of ERVWE1/Syncytin-1 and other placentally expressed human endogenous retroviruses along the malignant transformation process of hydatidiform moles.
Bolze PA, Patrier S, Cheynet V, Oriol G, Massardier J, Hajri T, Guillotte M, Bossus M, Sanlaville D, Golfier F, Mallet F
Placenta39116-24(2016 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Decreased syncytin-2 and MFSD2 proteins in gestational diabetic placentas might cause abnormal syncytiotrophoblast formation and possibly be involved in the pathology
Title: Altered expression of human endogenous retroviruses syncytin-1, syncytin-2 and their receptors in human normal and gestational diabetic placenta.

N-glycans at residues 133, 312, 332 and 443 of syncytin-2 are required for optimal fusion induction, and that single-nucleotide polymorphism C46R, N118S, T367M, R417H, V483I and T522M can alter the fusogenic function of syncytin-2.
Title: Effects of individually silenced N-glycosylation sites and non-synonymous single-nucleotide polymorphisms on the fusogenic function of human syncytin-2.

ERVWE1, ERVFRDE1 and ERV3 transcription was down-regulated in hydatidiform moles and gestational trophoblastic neoplasia.
Title: Expression patterns of ERVWE1/Syncytin-1 and other placentally expressed human endogenous retroviruses along the malignant transformation process of hydatidiform moles.

These results thereby demonstrate that induced expression of Syncytin-2 is highly dependent on the interaction of bZIP-containing transcription factors to a CRE/AP-1 motif and that this element is important for the regulation of Syncytin-2 expression
Title: A CRE/AP-1-like motif is essential for induced syncytin-2 expression and fusion in human trophoblast-like model.

MFSD2a, the Syncytin-2 receptor, is important for trophoblast fusion.
Title: MFSD2a, the Syncytin-2 receptor, is important for trophoblast fusion.

The following ERVFRD-1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ERVFRD-1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu08114	NM_207582.3 Latest version!	Homo sapiens endogenous retrovirus group FRD member 1, envelope (ERVFRD-1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
View Old Accession Versions >>
OHu08114	NM_207582.2	Homo sapiens endogenous retrovirus group FRD member 1, envelope (ERVFRD-1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

ERVFRD-1 ( NM_207582.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_997465.1 Homo sapiens endogenous retrovirus group FRD member 1, envelope (ERVFRD-1), mRNA.

Price & Availability↑

CloneID	OHu08114
Clone ID Related Accession (Same CDS sequence)	NM_207582.3 , NM_207582.2
Accession Version	NM_207582.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1617bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-26
Organism	Homo sapiens(human)
Product	syncytin-2 preproprotein
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC068585.1 and AL136139.6. On Nov 23, 2018 this sequence version replaced NM_207582.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC068585.1, AK123938.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## endogenous retrovirus :: PMID: 14557543 MANE Ensembl match :: ENST00000472091.2/ ENSP00000420174.1 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGGCCTGC TCCTGCTGGT TCTCATTCTC ACGCCTTCAC TAGCAGCCTA CCGCCATCCT 
GATTTCCCGT TATTGGAAAA AGCTCAGCAA CTGCTCCAAA GTACAGGATC CCCTTACTCC 
ACCAATTGCT GGTTATGTAC TAGCTCTTCC ACTGAAACAC CAGGGACAGC TTATCCAGCC 
TCGCCCAGAG AATGGACAAG CATAGAGGCG GAATTACATA TTTCCTATCG ATGGGACCCT 
AATCTGAAAG GACTGATGAG GCCTGCAAAT AGTCTTCTTT CAACAGTAAA GCAAGATTTC 
CCTGATATCC GCCAGAAACC TCCCATTTTC GGACCCATCT TTACTAATAT CAACCTAATG 
GGAATAGCCC CTATTTGTGT TATGGCCAAA AGGAAAAATG GAACAAATGT AGGCACTCTT 
CCAAGTACAG TCTGTAATGT TACTTTCACT GTAGATTCTA ACCAACAGAC TTACCAAACA 
TACACCCACA ACCAATTCCG CCATCAACCA AGATTCCCCA AACCTCCAAA TATTACTTTT 
CCTCAGGGAA CTTTGCTAGA TAAATCCAGC CGGTTTTGCC AGGGACGCCC AAGCTCATGC 
AGTACTCGAA ACTTCTGGTT CCGGCCTGCT GATTATAACC AATGTCTGCA AATTTCCAAC 
CTCAGCTCTA CAGCGGAATG GGTTCTATTG GACCAAACTC GAAATTCTCT TTTTTGGGAA 
AATAAAACCA AGGGAGCTAA CCAGAGCCAA ACACCCTGCG TCCAAGTCTT AGCAGGCATG 
ACTATAGCCA CCAGCTACCT GGGCATATCA GCAGTCTCAG AATTTTTTGG AACCTCCCTC 
ACCCCCTTAT TTCATTTCCA TATCTCTACA TGCCTTAAAA CTCAAGGAGC CTTTTATATT 
TGTGGCCAGT CGATTCACCA ATGCCTCCCC AGTAACTGGA CTGGAACTTG TACCATAGGC 
TATGTAACCC CAGACATCTT CATAGCCCCT GGCAATCTCT CTCTTCCAAT ACCAATCTAT 
GGGAATTCCC CGTTGCCCAG GGTGAGGAGG GCAATCCATT TCATTCCCCT TCTCGCGGGA 
CTCGGCATTC TAGCTGGTAC GGGAACCGGA ATTGCTGGAA TCACAAAAGC TTCCCTCACC 
TATAGCCAGC TCTCAAAGGA AATAGCCAAC AACATTGACA CCATGGCTAA AGCCTTAACG 
ACCATGCAAG AACAAATCGA CTCTTTAGCA GCCGTAGTCC TTCAAAATCG TCGAGGACTA 
GACATGTTAA CGGCAGCACA GGGAGGAATT TGTTTGGCCT TAGATGAAAA ATGTTGCTTT 
TGGGTAAATC AATCAGGAAA AGTACAAGAC AACATCAGAC AACTCCTAAA TCAAGCCTCC 
AGTTTACGGG AACGAGCCAC TCAGGGTTGG TTAAATTGGG AAGGAACTTG GAAATGGTTC 
TCTTGGGTTC TTCCCCTTAC AGGCCCACTT GTTAGTCTCC TACTTTTGCT CCTTTTTGGT 
CCATGTCTCC TAAATCTAAT AACCCAATTT GTCTCCTCTC GCCTTCAGGC CATAAAGCTC 
CAGACGAATC TCAGTGCAGG ACGCCATCCT CGCAATATTC AAGAGTCACC CTTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_997465.1
CDS	370..1986
Translation	MGLLLLVLILTPSLAAYRHPDFPLLEKAQQLLQSTGSPYSTNCWLCTSSSTETPGTAYPASPREWTSIEAELHISYRWDPNLKGLMRPANSLLSTVKQDFPDIRQKPPIFGPIFTNINLMGIAPICVMAKRKNGTNVGTLPSTVCNVTFTVDSNQQTYQTYTHNQFRHQPRFPKPPNITFPQGTLLDKSSRFCQGRPSSCSTRNFWFRPADYNQCLQISNLSSTAEWVLLDQTRNSLFWENKTKGANQSQTPCVQVLAGMTIATSYLGISAVSEFFGTSLTPLFHFHISTCLKTQGAFYICGQSIHQCLPSNWTGTCTIGYVTPDIFIAPGNLSLPIPIYGNSPLPRVRRAIHFIPLLAGLGILAGTGTGIAGITKASLTYSQLSKEIANNIDTMAKALTTMQEQIDSLAAVVLQNRRGLDMLTAAQGGICLALDEKCCFWVNQSGKVQDNIRQLLNQASSLRERATQGWLNWEGTWKWFSWVLPLTGPLVSLLLLLLFGPCLLNLITQFVSSRLQAIKLQTNLSAGRHPRNIQESPF

Target ORF information:

RefSeq Version	NM_207582.3
Organism	Homo sapiens(human)
Definition	Homo sapiens endogenous retrovirus group FRD member 1, envelope (ERVFRD-1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_207582.3

ORF Insert Sequence:

ATGGGCCTGC TCCTGCTGGT TCTCATTCTC ACGCCTTCAC TAGCAGCCTA CCGCCATCCT 
GATTTCCCGT TATTGGAAAA AGCTCAGCAA CTGCTCCAAA GTACAGGATC CCCTTACTCC 
ACCAATTGCT GGTTATGTAC TAGCTCTTCC ACTGAAACAC CAGGGACAGC TTATCCAGCC 
TCGCCCAGAG AATGGACAAG CATAGAGGCG GAATTACATA TTTCCTATCG ATGGGACCCT 
AATCTGAAAG GACTGATGAG GCCTGCAAAT AGTCTTCTTT CAACAGTAAA GCAAGATTTC 
CCTGATATCC GCCAGAAACC TCCCATTTTC GGACCCATCT TTACTAATAT CAACCTAATG 
GGAATAGCCC CTATTTGTGT TATGGCCAAA AGGAAAAATG GAACAAATGT AGGCACTCTT 
CCAAGTACAG TCTGTAATGT TACTTTCACT GTAGATTCTA ACCAACAGAC TTACCAAACA 
TACACCCACA ACCAATTCCG CCATCAACCA AGATTCCCCA AACCTCCAAA TATTACTTTT 
CCTCAGGGAA CTTTGCTAGA TAAATCCAGC CGGTTTTGCC AGGGACGCCC AAGCTCATGC 
AGTACTCGAA ACTTCTGGTT CCGGCCTGCT GATTATAACC AATGTCTGCA AATTTCCAAC 
CTCAGCTCTA CAGCGGAATG GGTTCTATTG GACCAAACTC GAAATTCTCT TTTTTGGGAA 
AATAAAACCA AGGGAGCTAA CCAGAGCCAA ACACCCTGCG TCCAAGTCTT AGCAGGCATG 
ACTATAGCCA CCAGCTACCT GGGCATATCA GCAGTCTCAG AATTTTTTGG AACCTCCCTC 
ACCCCCTTAT TTCATTTCCA TATCTCTACA TGCCTTAAAA CTCAAGGAGC CTTTTATATT 
TGTGGCCAGT CGATTCACCA ATGCCTCCCC AGTAACTGGA CTGGAACTTG TACCATAGGC 
TATGTAACCC CAGACATCTT CATAGCCCCT GGCAATCTCT CTCTTCCAAT ACCAATCTAT 
GGGAATTCCC CGTTGCCCAG GGTGAGGAGG GCAATCCATT TCATTCCCCT TCTCGCGGGA 
CTCGGCATTC TAGCTGGTAC GGGAACCGGA ATTGCTGGAA TCACAAAAGC TTCCCTCACC 
TATAGCCAGC TCTCAAAGGA AATAGCCAAC AACATTGACA CCATGGCTAA AGCCTTAACG 
ACCATGCAAG AACAAATCGA CTCTTTAGCA GCCGTAGTCC TTCAAAATCG TCGAGGACTA 
GACATGTTAA CGGCAGCACA GGGAGGAATT TGTTTGGCCT TAGATGAAAA ATGTTGCTTT 
TGGGTAAATC AATCAGGAAA AGTACAAGAC AACATCAGAC AACTCCTAAA TCAAGCCTCC 
AGTTTACGGG AACGAGCCAC TCAGGGTTGG TTAAATTGGG AAGGAACTTG GAAATGGTTC 
TCTTGGGTTC TTCCCCTTAC AGGCCCACTT GTTAGTCTCC TACTTTTGCT CCTTTTTGGT 
CCATGTCTCC TAAATCTAAT AACCCAATTT GTCTCCTCTC GCCTTCAGGC CATAAAGCTC 
CAGACGAATC TCAGTGCAGG ACGCCATCCT CGCAATATTC AAGAGTCACC CTTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ERVFRD-1 ( NM_207582.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_997465.1 Homo sapiens endogenous retrovirus group FRD member 1, envelope (ERVFRD-1), mRNA.

Price & Availability↑

CloneID	OHu08114
Clone ID Related Accession (Same CDS sequence)	NM_207582.3 , NM_207582.2
Accession Version	NM_207582.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1617bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	syncytin-2 preproprotein
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DA863475.1, BC068585.1 and AL136139.6. On Sep 22, 2009 this sequence version replaced NM_207582.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC068585.1, AK123938.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## endogenous retrovirus :: PMID: 14557543 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGGCCTGC TCCTGCTGGT TCTCATTCTC ACGCCTTCAC TAGCAGCCTA CCGCCATCCT 
GATTTCCCGT TATTGGAAAA AGCTCAGCAA CTGCTCCAAA GTACAGGATC CCCTTACTCC 
ACCAATTGCT GGTTATGTAC TAGCTCTTCC ACTGAAACAC CAGGGACAGC TTATCCAGCC 
TCGCCCAGAG AATGGACAAG CATAGAGGCG GAATTACATA TTTCCTATCG ATGGGACCCT 
AATCTGAAAG GACTGATGAG GCCTGCAAAT AGTCTTCTTT CAACAGTAAA GCAAGATTTC 
CCTGATATCC GCCAGAAACC TCCCATTTTC GGACCCATCT TTACTAATAT CAACCTAATG 
GGAATAGCCC CTATTTGTGT TATGGCCAAA AGGAAAAATG GAACAAATGT AGGCACTCTT 
CCAAGTACAG TCTGTAATGT TACTTTCACT GTAGATTCTA ACCAACAGAC TTACCAAACA 
TACACCCACA ACCAATTCCG CCATCAACCA AGATTCCCCA AACCTCCAAA TATTACTTTT 
CCTCAGGGAA CTTTGCTAGA TAAATCCAGC CGGTTTTGCC AGGGACGCCC AAGCTCATGC 
AGTACTCGAA ACTTCTGGTT CCGGCCTGCT GATTATAACC AATGTCTGCA AATTTCCAAC 
CTCAGCTCTA CAGCGGAATG GGTTCTATTG GACCAAACTC GAAATTCTCT TTTTTGGGAA 
AATAAAACCA AGGGAGCTAA CCAGAGCCAA ACACCCTGCG TCCAAGTCTT AGCAGGCATG 
ACTATAGCCA CCAGCTACCT GGGCATATCA GCAGTCTCAG AATTTTTTGG AACCTCCCTC 
ACCCCCTTAT TTCATTTCCA TATCTCTACA TGCCTTAAAA CTCAAGGAGC CTTTTATATT 
TGTGGCCAGT CGATTCACCA ATGCCTCCCC AGTAACTGGA CTGGAACTTG TACCATAGGC 
TATGTAACCC CAGACATCTT CATAGCCCCT GGCAATCTCT CTCTTCCAAT ACCAATCTAT 
GGGAATTCCC CGTTGCCCAG GGTGAGGAGG GCAATCCATT TCATTCCCCT TCTCGCGGGA 
CTCGGCATTC TAGCTGGTAC GGGAACCGGA ATTGCTGGAA TCACAAAAGC TTCCCTCACC 
TATAGCCAGC TCTCAAAGGA AATAGCCAAC AACATTGACA CCATGGCTAA AGCCTTAACG 
ACCATGCAAG AACAAATCGA CTCTTTAGCA GCCGTAGTCC TTCAAAATCG TCGAGGACTA 
GACATGTTAA CGGCAGCACA GGGAGGAATT TGTTTGGCCT TAGATGAAAA ATGTTGCTTT 
TGGGTAAATC AATCAGGAAA AGTACAAGAC AACATCAGAC AACTCCTAAA TCAAGCCTCC 
AGTTTACGGG AACGAGCCAC TCAGGGTTGG TTAAATTGGG AAGGAACTTG GAAATGGTTC 
TCTTGGGTTC TTCCCCTTAC AGGCCCACTT GTTAGTCTCC TACTTTTGCT CCTTTTTGGT 
CCATGTCTCC TAAATCTAAT AACCCAATTT GTCTCCTCTC GCCTTCAGGC CATAAAGCTC 
CAGACGAATC TCAGTGCAGG ACGCCATCCT CGCAATATTC AAGAGTCACC CTTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_997465.1
CDS	483..2099
Translation	MGLLLLVLILTPSLAAYRHPDFPLLEKAQQLLQSTGSPYSTNCWLCTSSSTETPGTAYPASPREWTSIEAELHISYRWDPNLKGLMRPANSLLSTVKQDFPDIRQKPPIFGPIFTNINLMGIAPICVMAKRKNGTNVGTLPSTVCNVTFTVDSNQQTYQTYTHNQFRHQPRFPKPPNITFPQGTLLDKSSRFCQGRPSSCSTRNFWFRPADYNQCLQISNLSSTAEWVLLDQTRNSLFWENKTKGANQSQTPCVQVLAGMTIATSYLGISAVSEFFGTSLTPLFHFHISTCLKTQGAFYICGQSIHQCLPSNWTGTCTIGYVTPDIFIAPGNLSLPIPIYGNSPLPRVRRAIHFIPLLAGLGILAGTGTGIAGITKASLTYSQLSKEIANNIDTMAKALTTMQEQIDSLAAVVLQNRRGLDMLTAAQGGICLALDEKCCFWVNQSGKVQDNIRQLLNQASSLRERATQGWLNWEGTWKWFSWVLPLTGPLVSLLLLLLFGPCLLNLITQFVSSRLQAIKLQTNLSAGRHPRNIQESPF

Target ORF information:

RefSeq Version	NM_207582.2
Organism	Homo sapiens(human)
Definition	Homo sapiens endogenous retrovirus group FRD member 1, envelope (ERVFRD-1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_207582.2

ORF Insert Sequence:

ATGGGCCTGC TCCTGCTGGT TCTCATTCTC ACGCCTTCAC TAGCAGCCTA CCGCCATCCT 
GATTTCCCGT TATTGGAAAA AGCTCAGCAA CTGCTCCAAA GTACAGGATC CCCTTACTCC 
ACCAATTGCT GGTTATGTAC TAGCTCTTCC ACTGAAACAC CAGGGACAGC TTATCCAGCC 
TCGCCCAGAG AATGGACAAG CATAGAGGCG GAATTACATA TTTCCTATCG ATGGGACCCT 
AATCTGAAAG GACTGATGAG GCCTGCAAAT AGTCTTCTTT CAACAGTAAA GCAAGATTTC 
CCTGATATCC GCCAGAAACC TCCCATTTTC GGACCCATCT TTACTAATAT CAACCTAATG 
GGAATAGCCC CTATTTGTGT TATGGCCAAA AGGAAAAATG GAACAAATGT AGGCACTCTT 
CCAAGTACAG TCTGTAATGT TACTTTCACT GTAGATTCTA ACCAACAGAC TTACCAAACA 
TACACCCACA ACCAATTCCG CCATCAACCA AGATTCCCCA AACCTCCAAA TATTACTTTT 
CCTCAGGGAA CTTTGCTAGA TAAATCCAGC CGGTTTTGCC AGGGACGCCC AAGCTCATGC 
AGTACTCGAA ACTTCTGGTT CCGGCCTGCT GATTATAACC AATGTCTGCA AATTTCCAAC 
CTCAGCTCTA CAGCGGAATG GGTTCTATTG GACCAAACTC GAAATTCTCT TTTTTGGGAA 
AATAAAACCA AGGGAGCTAA CCAGAGCCAA ACACCCTGCG TCCAAGTCTT AGCAGGCATG 
ACTATAGCCA CCAGCTACCT GGGCATATCA GCAGTCTCAG AATTTTTTGG AACCTCCCTC 
ACCCCCTTAT TTCATTTCCA TATCTCTACA TGCCTTAAAA CTCAAGGAGC CTTTTATATT 
TGTGGCCAGT CGATTCACCA ATGCCTCCCC AGTAACTGGA CTGGAACTTG TACCATAGGC 
TATGTAACCC CAGACATCTT CATAGCCCCT GGCAATCTCT CTCTTCCAAT ACCAATCTAT 
GGGAATTCCC CGTTGCCCAG GGTGAGGAGG GCAATCCATT TCATTCCCCT TCTCGCGGGA 
CTCGGCATTC TAGCTGGTAC GGGAACCGGA ATTGCTGGAA TCACAAAAGC TTCCCTCACC 
TATAGCCAGC TCTCAAAGGA AATAGCCAAC AACATTGACA CCATGGCTAA AGCCTTAACG 
ACCATGCAAG AACAAATCGA CTCTTTAGCA GCCGTAGTCC TTCAAAATCG TCGAGGACTA 
GACATGTTAA CGGCAGCACA GGGAGGAATT TGTTTGGCCT TAGATGAAAA ATGTTGCTTT 
TGGGTAAATC AATCAGGAAA AGTACAAGAC AACATCAGAC AACTCCTAAA TCAAGCCTCC 
AGTTTACGGG AACGAGCCAC TCAGGGTTGG TTAAATTGGG AAGGAACTTG GAAATGGTTC 
TCTTGGGTTC TTCCCCTTAC AGGCCCACTT GTTAGTCTCC TACTTTTGCT CCTTTTTGGT 
CCATGTCTCC TAAATCTAAT AACCCAATTT GTCTCCTCTC GCCTTCAGGC CATAAAGCTC 
CAGACGAATC TCAGTGCAGG ACGCCATCCT CGCAATATTC AAGAGTCACC CTTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The role of syncytins in human reproduction and reproductive organ cancers.
Reproduction (Cambridge, England)152(5)R167-78(2016 11)
Soygur B,Sati L

Altered expression of human endogenous retroviruses syncytin-1, syncytin-2 and their receptors in human normal and gestational diabetic placenta.
Histology and histopathology31(9)1037-47(2016 Sep)
Soygur B,Sati L,Demir R

Effects of individually silenced N-glycosylation sites and non-synonymous single-nucleotide polymorphisms on the fusogenic function of human syncytin-2.
Cell adhesion & migration10(1-2)39-55(2016 Mar)
Cui L,Wang H,Lu X,Wang R,Zheng R,Li Y,Yang X,Jia WT,Zhao Y,Wang Y,Wang H,Wang YL,Zhu C,Lin HY,Wang H

Expression patterns of ERVWE1/Syncytin-1 and other placentally expressed human endogenous retroviruses along the malignant transformation process of hydatidiform moles.
Placenta39116-24(2016 Mar)
Bolze PA,Patrier S,Cheynet V,Oriol G,Massardier J,Hajri T,Guillotte M,Bossus M,Sanlaville D,Golfier F,Mallet F

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ERVFRD-1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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