DUOXA2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	DUOXA2
Entrez Gene ID	405753
Full Name	dual oxidase maturation factor 2
Synonyms	SIMNIPHOM,TDH5
General protein information	Preferred Names dual oxidase maturation factor 2 Names dual oxidase maturation factor 2
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 15 Map Location: 15q21.1
Summary	This gene encodes an endoplasmic reticulum protein that is necessary for proper cellular localization and maturation of functional dual oxidase 2. Mutations in this gene have been associated with thyroid dyshormonogenesis 5.[provided by RefSeq, Feb 2010].
Disorder MIM:	612772
Disorder Html:	Thyroid dyshormonogenesis 5, 274900 (3)

mRNA and Protein(s)

mRNA	Protein	Name
XM_017022180.1	XP_016877669.1	dual oxidase maturation factor 2 isoform X1
NM_207581.4	NP_997464.2	dual oxidase maturation factor 2
NM_207581.3	NP_997464.2	dual oxidase maturation factor 2

Pathways from BioSystems

Homologies

Gallus gallus (chicken)	DUOXA1	XP_425055.2
	DUOXA2	XP_001111110.1
Mus musculus (house mouse)	Duoxa2	NP_080053.1
Rattus norvegicus (Norway rat)	Duoxa2	NP_001178894.1
Danio rerio (zebrafish)	LOC100330288	XP_002666953.2
Xenopus tropicalis (tropical clawed frog)	LOC101733132	XP_004918326.1
Pan troglodytes (chimpanzee)	DUOXA2	XP_001146826.2
Bos taurus (cattle)	DUOXA2	XP_002690989.1
Gallus gallus (chicken)	DUOXA1L	XP_425054.2
Canis lupus familiaris (dog)	DUOXA2	XP_003640075.2
Homo sapiens (human)	DUOXA2	NP_997464.2

Gene Ontology
Bibliography

Related articles in PubMed

Compound Heterozygous Mutations in the DUOX2/DUOXA2 Genes Cause Congenital Hypothyroidism.
Zheng X, Ma SG, Guo ML, Qiu YL, Yang LX
Yonsei medical journal58(4)888-890(2017 Jul)

[Characteristics of DUOXA2 gene mutation in children with congenital hypothyroidism].
Tan MY, Huang YL, Li B, Jiang X, Chen QY, Jia XF, Tang CF, Liu L
Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics19(1)59-63(2017 Jan)

Heterozygous Mutations of the DUOXA2 and DUOX2 Genes in Dizygotic Twins with Congenital Hypothyroidism.
Yang LX, Ma SG, Qiu YL, Zheng X
Clinical laboratory62(5)849-54(2016)

When an Intramolecular Disulfide Bridge Governs the Interaction of DUOX2 with Its Partner DUOXA2.
Carr? A, Louzada RA, Fortunato RS, Ameziane-El-Hassani R, Morand S, Ogryzko V, de Carvalho DP, Grasberger H, Leto TL, Dupuy C
Antioxidants & redox signaling23(9)724-33(2015 Sep)

Up-regulation and sustained activation of Stat1 are essential for interferon-gamma (IFN-gamma)-induced dual oxidase 2 (Duox2) and dual oxidase A2 (DuoxA2) expression in human pancreatic cancer cell lines.
Wu Y, Antony S, Juhasz A, Lu J, Ge Y, Jiang G, Roy K, Doroshow JH
The Journal of biological chemistry286(14)12245-56(2011 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

This study reports the pedigree with goitrous congenital hypothyroidism (GCH) due to the coexistence of heterozygous mutations in the DUOX2 and DUOXA2 genes.
Title: Compound Heterozygous Mutations in the DUOX2/DUOXA2 Genes Cause Congenital Hypothyroidism.

DUOXA2 gene mutation is a common molecular pathogenic basis for congenital hypothyroidism children with suspected thyroid dyshormonogenesis in Guangzhou.
Title: [Characteristics of DUOXA2 gene mutation in children with congenital hypothyroidism].

inactivating mutations in the DUOXA2 (p.Y246X) and DUOX2 (p.R885Q) genes were identified in a set of dizygotic twins with congenital hypothyroidism
Title: Heterozygous Mutations of the DUOXA2 and DUOX2 Genes in Dizygotic Twins with Congenital Hypothyroidism.

The folding of DUOX2 appears to be a key event in the trafficking of the DUOX2/DUOXA2 complex as it promotes an appropriate conformation of the N-terminal region, which is propitious to subsequent covalent interactions with the maturation factor, DUOXA2.
Title: When an Intramolecular Disulfide Bridge Governs the Interaction of DUOX2 with Its Partner DUOXA2.

a novel DUOXA2 mutation (I26M) causing congenital hypothyroidism with goiter, which affected H2O2 generation but did not alter the protein expression levels, further confirming the essential role of DUOXA2 in thyroid hormone synthesis.
Title: A novel missense mutation (I26M) in DUOXA2 causing congenital goiter hypothyroidism impairs NADPH oxidase activity but not protein expression.

The following DUOXA2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the DUOXA2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu18591	NM_207581.4 Latest version!	Homo sapiens dual oxidase maturation factor 2 (DUOXA2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
OHu85405	XM_017022180.1 Latest version!	Homo sapiens dual oxidase maturation factor 2 (DUOXA2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00
View Old Accession Versions >>
OHu18591	NM_207581.3	Homo sapiens dual oxidase maturation factor 2 (DUOXA2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$216.30 $309.00
Hide Old Accession Versions >>

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

DUOXA2 ( NM_207581.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_997464.2 Homo sapiens dual oxidase maturation factor 2 (DUOXA2), mRNA.

Price & Availability↑

CloneID	OHu18591
Clone ID Related Accession (Same CDS sequence)	NM_207581.4 , NM_207581.3
Accession Version	NM_207581.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 963bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-01
Organism	Homo sapiens(human)
Product	dual oxidase maturation factor 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC393748.1, BC137465.1, BM987789.1 and AC091117.5. This sequence is a reference standard in the RefSeqGene project. On May 17, 2019 this sequence version replaced NM_207581.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC137465.1, DQ489734.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000323030.6/ ENSP00000319705.5 RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGACCCTGT GGAACGGCGT ACTGCCTTTT TACCCCCAGC CCCGGCATGC CGCAGGCTTC 
AGCGTTCCAC TGCTCATCGT TATTCTAGTG TTTTTGGCTC TAGCAGCAAG CTTCCTGCTC 
ATCTTGCCGG GGATCCGTGG CCACTCGCGC TGGTTTTGGT TGGTGAGAGT TCTTCTCAGT 
CTGTTCATAG GCGCAGAAAT TGTGGCTGTG CACTTCAGTG CAGAATGGTT CGTGGGTACA 
GTGAACACCA ACACATCCTA CAAAGCCTTC AGCGCAGCGC GCGTTACAGC CCGTGTCCGT 
CTGCTCGTGG GCCTGGAGGG CATTAATATT ACACTCACAG GGACCCCAGT GCATCAGCTG 
AACGAGACCA TTGACTACAA CGAGCAGTTC ACCTGGCGTC TGAAAGAGAA TTACGCCGCG 
GAGTACGCGA ACGCACTGGA GAAGGGGCTG CCGGACCCAG TGCTCTACCT GGCGGAGAAG 
TTCACACCGA GTAGCCCTTG CGGCCTGTAC CACCAGTACC ACCTGGCGGG ACACTACGCC 
TCGGCCACGC TATGGGTGGC GTTCTGCTTC TGGCTCCTCT CCAACGTGCT GCTCTCCACG 
CCGGCCCCGC TCTACGGAGG CCTGGCACTG CTGACCACCG GAGCCTTCGC GCTCTTCGGG 
GTCTTCGCCT TGGCCTCCAT CTCTAGCGTG CCGCTCTGCC CGCTCCGCCT AGGCTCCTCC 
GCGCTCACCA CTCAGTACGG CGCCGCCTTC TGGGTCACGC TGGCAACCGG CGTCCTGTGC 
CTCTTCCTCG GAGGGGCCGT GGTGAGTCTC CAGTATGTTC GGCCCAGCGC TCTTCGCACC 
CTTCTGGACC AAAGCGCCAA GGACTGCAGC CAGGAGAGAG GGGGCTCACC TCTTATCCTC 
GGCGACCCAC TGCACAAGCA GGCCGCTCTC CCAGACTTAA AATGTATCAC CACTAACCTG 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_997464.2
CDS	281..1243
Translation	MTLWNGVLPFYPQPRHAAGFSVPLLIVILVFLALAASFLLILPGIRGHSRWFWLVRVLLSLFIGAEIVAVHFSAEWFVGTVNTNTSYKAFSAARVTARVRLLVGLEGINITLTGTPVHQLNETIDYNEQFTWRLKENYAAEYANALEKGLPDPVLYLAEKFTPSSPCGLYHQYHLAGHYASATLWVAFCFWLLSNVLLSTPAPLYGGLALLTTGAFALFGVFALASISSVPLCPLRLGSSALTTQYGAAFWVTLATGVLCLFLGGAVVSLQYVRPSALRTLLDQSAKDCSQERGGSPLILGDPLHKQAALPDLKCITTNL

Target ORF information:

RefSeq Version	NM_207581.4
Organism	Homo sapiens(human)
Definition	Homo sapiens dual oxidase maturation factor 2 (DUOXA2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_207581.4

ORF Insert Sequence:

ATGACCCTGT GGAACGGCGT ACTGCCTTTT TACCCCCAGC CCCGGCATGC CGCAGGCTTC 
AGCGTTCCAC TGCTCATCGT TATTCTAGTG TTTTTGGCTC TAGCAGCAAG CTTCCTGCTC 
ATCTTGCCGG GGATCCGTGG CCACTCGCGC TGGTTTTGGT TGGTGAGAGT TCTTCTCAGT 
CTGTTCATAG GCGCAGAAAT TGTGGCTGTG CACTTCAGTG CAGAATGGTT CGTGGGTACA 
GTGAACACCA ACACATCCTA CAAAGCCTTC AGCGCAGCGC GCGTTACAGC CCGTGTCCGT 
CTGCTCGTGG GCCTGGAGGG CATTAATATT ACACTCACAG GGACCCCAGT GCATCAGCTG 
AACGAGACCA TTGACTACAA CGAGCAGTTC ACCTGGCGTC TGAAAGAGAA TTACGCCGCG 
GAGTACGCGA ACGCACTGGA GAAGGGGCTG CCGGACCCAG TGCTCTACCT GGCGGAGAAG 
TTCACACCGA GTAGCCCTTG CGGCCTGTAC CACCAGTACC ACCTGGCGGG ACACTACGCC 
TCGGCCACGC TATGGGTGGC GTTCTGCTTC TGGCTCCTCT CCAACGTGCT GCTCTCCACG 
CCGGCCCCGC TCTACGGAGG CCTGGCACTG CTGACCACCG GAGCCTTCGC GCTCTTCGGG 
GTCTTCGCCT TGGCCTCCAT CTCTAGCGTG CCGCTCTGCC CGCTCCGCCT AGGCTCCTCC 
GCGCTCACCA CTCAGTACGG CGCCGCCTTC TGGGTCACGC TGGCAACCGG CGTCCTGTGC 
CTCTTCCTCG GAGGGGCCGT GGTGAGTCTC CAGTATGTTC GGCCCAGCGC TCTTCGCACC 
CTTCTGGACC AAAGCGCCAA GGACTGCAGC CAGGAGAGAG GGGGCTCACC TCTTATCCTC 
GGCGACCCAC TGCACAAGCA GGCCGCTCTC CCAGACTTAA AATGTATCAC CACTAACCTG 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DUOXA2 ( NM_207581.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_997464.2 Homo sapiens dual oxidase maturation factor 2 (DUOXA2), mRNA.

Price & Availability↑

CloneID	OHu18591
Clone ID Related Accession (Same CDS sequence)	NM_207581.4 , NM_207581.3
Accession Version	NM_207581.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 963bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-21
Organism	Homo sapiens(human)
Product	dual oxidase maturation factor 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC393748.1, BC137465.1 and BM987789.1. This sequence is a reference standard in the RefSeqGene project. On Feb 13, 2010 this sequence version replaced NM_207581.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: DQ489734.1, ERR279839.5520.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGACCCTGT GGAACGGCGT ACTGCCTTTT TACCCCCAGC CCCGGCATGC CGCAGGCTTC 
AGCGTTCCAC TGCTCATCGT TATTCTAGTG TTTTTGGCTC TAGCAGCAAG CTTCCTGCTC 
ATCTTGCCGG GGATCCGTGG CCACTCGCGC TGGTTTTGGT TGGTGAGAGT TCTTCTCAGT 
CTGTTCATAG GCGCAGAAAT TGTGGCTGTG CACTTCAGTG CAGAATGGTT CGTGGGTACA 
GTGAACACCA ACACATCCTA CAAAGCCTTC AGCGCAGCGC GCGTTACAGC CCGTGTCCGT 
CTGCTCGTGG GCCTGGAGGG CATTAATATT ACACTCACAG GGACCCCAGT GCATCAGCTG 
AACGAGACCA TTGACTACAA CGAGCAGTTC ACCTGGCGTC TGAAAGAGAA TTACGCCGCG 
GAGTACGCGA ACGCACTGGA GAAGGGGCTG CCGGACCCAG TGCTCTACCT GGCGGAGAAG 
TTCACACCGA GTAGCCCTTG CGGCCTGTAC CACCAGTACC ACCTGGCGGG ACACTACGCC 
TCGGCCACGC TATGGGTGGC GTTCTGCTTC TGGCTCCTCT CCAACGTGCT GCTCTCCACG 
CCGGCCCCGC TCTACGGAGG CCTGGCACTG CTGACCACCG GAGCCTTCGC GCTCTTCGGG 
GTCTTCGCCT TGGCCTCCAT CTCTAGCGTG CCGCTCTGCC CGCTCCGCCT AGGCTCCTCC 
GCGCTCACCA CTCAGTACGG CGCCGCCTTC TGGGTCACGC TGGCAACCGG CGTCCTGTGC 
CTCTTCCTCG GAGGGGCCGT GGTGAGTCTC CAGTATGTTC GGCCCAGCGC TCTTCGCACC 
CTTCTGGACC AAAGCGCCAA GGACTGCAGC CAGGAGAGAG GGGGCTCACC TCTTATCCTC 
GGCGACCCAC TGCACAAGCA GGCCGCTCTC CCAGACTTAA AATGTATCAC CACTAACCTG 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_997464.2
CDS	282..1244
Translation	MTLWNGVLPFYPQPRHAAGFSVPLLIVILVFLALAASFLLILPGIRGHSRWFWLVRVLLSLFIGAEIVAVHFSAEWFVGTVNTNTSYKAFSAARVTARVRLLVGLEGINITLTGTPVHQLNETIDYNEQFTWRLKENYAAEYANALEKGLPDPVLYLAEKFTPSSPCGLYHQYHLAGHYASATLWVAFCFWLLSNVLLSTPAPLYGGLALLTTGAFALFGVFALASISSVPLCPLRLGSSALTTQYGAAFWVTLATGVLCLFLGGAVVSLQYVRPSALRTLLDQSAKDCSQERGGSPLILGDPLHKQAALPDLKCITTNL

Target ORF information:

RefSeq Version	NM_207581.3
Organism	Homo sapiens(human)
Definition	Homo sapiens dual oxidase maturation factor 2 (DUOXA2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_207581.3

ORF Insert Sequence:

ATGACCCTGT GGAACGGCGT ACTGCCTTTT TACCCCCAGC CCCGGCATGC CGCAGGCTTC 
AGCGTTCCAC TGCTCATCGT TATTCTAGTG TTTTTGGCTC TAGCAGCAAG CTTCCTGCTC 
ATCTTGCCGG GGATCCGTGG CCACTCGCGC TGGTTTTGGT TGGTGAGAGT TCTTCTCAGT 
CTGTTCATAG GCGCAGAAAT TGTGGCTGTG CACTTCAGTG CAGAATGGTT CGTGGGTACA 
GTGAACACCA ACACATCCTA CAAAGCCTTC AGCGCAGCGC GCGTTACAGC CCGTGTCCGT 
CTGCTCGTGG GCCTGGAGGG CATTAATATT ACACTCACAG GGACCCCAGT GCATCAGCTG 
AACGAGACCA TTGACTACAA CGAGCAGTTC ACCTGGCGTC TGAAAGAGAA TTACGCCGCG 
GAGTACGCGA ACGCACTGGA GAAGGGGCTG CCGGACCCAG TGCTCTACCT GGCGGAGAAG 
TTCACACCGA GTAGCCCTTG CGGCCTGTAC CACCAGTACC ACCTGGCGGG ACACTACGCC 
TCGGCCACGC TATGGGTGGC GTTCTGCTTC TGGCTCCTCT CCAACGTGCT GCTCTCCACG 
CCGGCCCCGC TCTACGGAGG CCTGGCACTG CTGACCACCG GAGCCTTCGC GCTCTTCGGG 
GTCTTCGCCT TGGCCTCCAT CTCTAGCGTG CCGCTCTGCC CGCTCCGCCT AGGCTCCTCC 
GCGCTCACCA CTCAGTACGG CGCCGCCTTC TGGGTCACGC TGGCAACCGG CGTCCTGTGC 
CTCTTCCTCG GAGGGGCCGT GGTGAGTCTC CAGTATGTTC GGCCCAGCGC TCTTCGCACC 
CTTCTGGACC AAAGCGCCAA GGACTGCAGC CAGGAGAGAG GGGGCTCACC TCTTATCCTC 
GGCGACCCAC TGCACAAGCA GGCCGCTCTC CCAGACTTAA AATGTATCAC CACTAACCTG 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DUOXA2 ( XM_017022180.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016877669.1 Homo sapiens dual oxidase maturation factor 2 (DUOXA2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu85405
Clone ID Related Accession (Same CDS sequence)	XM_017022180.1
Accession Version	XM_017022180.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1014bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	dual oxidase maturation factor 2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000015.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGACCCTGT GGAACGGCGT ACTGCCTTTT TACCCCCAGC CCCGGCATGC CGCAGGCTTC 
AGCGTTCCAC TGCTCATCGT TATTCTAGTG TTTTTGGCTC TAGCAGCAAG CTTCCTGCTC 
ATCTTGCCGG GGATCCGTGG CCACTCGCGC TGGTTTTGGT TGGTGAGAGT TCTTCTCAGT 
CTGTTCATAG GCGCAGAAAT TGTGGCTGTG CACTTCAGTG CAGAATGGTT CGTGGGTACA 
GTGAACACCA ACACATCCTA CAAAGCCTTC AGCGCAGCGC GCGTTACAGC CCGTGTCCGT 
CTGCTCGTGG GCCTGGAGGG CATTAATATT ACACTCACAG TTGCGAGGTC TCCGACCGCG 
GGCAGCCCCA TGAGCCCGCC TCACCCCACA GGGACCCCAG TGCATCAGCT GAACGAGACC 
ATTGACTACA ACGAGCAGTT CACCTGGCGT CTGAAAGAGA ATTACGCCGC GGAGTACGCG 
AACGCACTGG AGAAGGGGCT GCCGGACCCA GTGCTCTACC TGGCGGAGAA GTTCACACCG 
AGTAGCCCTT GCGGCCTGTA CCACCAGTAC CACCTGGCGG GACACTACGC CTCGGCCACG 
CTATGGGTGG CGTTCTGCTT CTGGCTCCTC TCCAACGTGC TGCTCTCCAC GCCGGCCCCG 
CTCTACGGAG GCCTGGCACT GCTGACCACC GGAGCCTTCG CGCTCTTCGG GGTCTTCGCC 
TTGGCCTCCA TCTCTAGCGT GCCGCTCTGC CCGCTCCGCC TAGGCTCCTC CGCGCTCACC 
ACTCAGTACG GCGCCGCCTT CTGGGTCACG CTGGCAACCG GCGTCCTGTG CCTCTTCCTC 
GGAGGGGCCG TGGTGAGTCT CCAGTATGTT CGGCCCAGCG CTCTTCGCAC CCTTCTGGAC 
CAAAGCGCCA AGGACTGCAG CCAGGAGAGA GGGGGCTCAC CTCTTATCCT CGGCGACCCA 
CTGCACAAGC AGGCCGCTCT CCCAGACTTA AAATGTATCA CCACTAACCT GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016877669.1
CDS	286..1299
Translation	MTLWNGVLPFYPQPRHAAGFSVPLLIVILVFLALAASFLLILPGIRGHSRWFWLVRVLLSLFIGAEIVAVHFSAEWFVGTVNTNTSYKAFSAARVTARVRLLVGLEGINITLTVARSPTAGSPMSPPHPTGTPVHQLNETIDYNEQFTWRLKENYAAEYANALEKGLPDPVLYLAEKFTPSSPCGLYHQYHLAGHYASATLWVAFCFWLLSNVLLSTPAPLYGGLALLTTGAFALFGVFALASISSVPLCPLRLGSSALTTQYGAAFWVTLATGVLCLFLGGAVVSLQYVRPSALRTLLDQSAKDCSQERGGSPLILGDPLHKQAALPDLKCITTNL

Target ORF information:

RefSeq Version	XM_017022180.1
Organism	Homo sapiens(human)
Definition	Homo sapiens dual oxidase maturation factor 2 (DUOXA2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017022180.1

ORF Insert Sequence:

ATGACCCTGT GGAACGGCGT ACTGCCTTTT TACCCCCAGC CCCGGCATGC CGCAGGCTTC 
AGCGTTCCAC TGCTCATCGT TATTCTAGTG TTTTTGGCTC TAGCAGCAAG CTTCCTGCTC 
ATCTTGCCGG GGATCCGTGG CCACTCGCGC TGGTTTTGGT TGGTGAGAGT TCTTCTCAGT 
CTGTTCATAG GCGCAGAAAT TGTGGCTGTG CACTTCAGTG CAGAATGGTT CGTGGGTACA 
GTGAACACCA ACACATCCTA CAAAGCCTTC AGCGCAGCGC GCGTTACAGC CCGTGTCCGT 
CTGCTCGTGG GCCTGGAGGG CATTAATATT ACACTCACAG TTGCGAGGTC TCCGACCGCG 
GGCAGCCCCA TGAGCCCGCC TCACCCCACA GGGACCCCAG TGCATCAGCT GAACGAGACC 
ATTGACTACA ACGAGCAGTT CACCTGGCGT CTGAAAGAGA ATTACGCCGC GGAGTACGCG 
AACGCACTGG AGAAGGGGCT GCCGGACCCA GTGCTCTACC TGGCGGAGAA GTTCACACCG 
AGTAGCCCTT GCGGCCTGTA CCACCAGTAC CACCTGGCGG GACACTACGC CTCGGCCACG 
CTATGGGTGG CGTTCTGCTT CTGGCTCCTC TCCAACGTGC TGCTCTCCAC GCCGGCCCCG 
CTCTACGGAG GCCTGGCACT GCTGACCACC GGAGCCTTCG CGCTCTTCGG GGTCTTCGCC 
TTGGCCTCCA TCTCTAGCGT GCCGCTCTGC CCGCTCCGCC TAGGCTCCTC CGCGCTCACC 
ACTCAGTACG GCGCCGCCTT CTGGGTCACG CTGGCAACCG GCGTCCTGTG CCTCTTCCTC 
GGAGGGGCCG TGGTGAGTCT CCAGTATGTT CGGCCCAGCG CTCTTCGCAC CCTTCTGGAC 
CAAAGCGCCA AGGACTGCAG CCAGGAGAGA GGGGGCTCAC CTCTTATCCT CGGCGACCCA 
CTGCACAAGC AGGCCGCTCT CCCAGACTTA AAATGTATCA CCACTAACCT GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Compound Heterozygous Mutations in the DUOX2/DUOXA2 Genes Cause Congenital Hypothyroidism.
Yonsei medical journal58(4)888-890(2017 Jul)
Zheng X,Ma SG,Guo ML,Qiu YL,Yang LX

[Characteristics of DUOXA2 gene mutation in children with congenital hypothyroidism].
Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics19(1)59-63(2017 Jan)
Tan MY,Huang YL,Li B,Jiang X,Chen QY,Jia XF,Tang CF,Liu L

Heterozygous Mutations of the DUOXA2 and DUOX2 Genes in Dizygotic Twins with Congenital Hypothyroidism.
Clinical laboratory62(5)849-54(2016)
Yang LX,Ma SG,Qiu YL,Zheng X

When an Intramolecular Disulfide Bridge Governs the Interaction of DUOX2 with Its Partner DUOXA2.
Antioxidants & redox signaling23(9)724-33(2015 Sep)
Carr? A,Louzada RA,Fortunato RS,Ameziane-El-Hassani R,Morand S,Ogryzko V,de Carvalho DP,Grasberger H,Leto TL,Dupuy C

Up-regulation and sustained activation of Stat1 are essential for interferon-gamma (IFN-gamma)-induced dual oxidase 2 (Duox2) and dual oxidase A2 (DuoxA2) expression in human pancreatic cancer cell lines.
The Journal of biological chemistry286(14)12245-56(2011 Apr)
Wu Y,Antony S,Juhasz A,Lu J,Ge Y,Jiang G,Roy K,Doroshow JH

見積依頼

Eメール

japanmarket@genscript.com

電話

03-6811-6572

FAX

03-6811-6573
050-3174-7589(受注専用)

オンラインフォーム

オンライン注文

DUOXA2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

見積依頼

Eメール

電話

FAX

オンラインフォーム

サポート

会社情報

サポート

会社情報