LRPAP1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	LRPAP1
Entrez Gene ID	4043
Full Name	LDL receptor related protein associated protein 1
Synonyms	A2MRAP,A2RAP,HBP44,MRAP,MYP23,RAP,alpha-2-MRAP
General protein information	Preferred Names LDL receptor related protein associated protein 1 Names alpha-2-macroglobulin receptor-associated protein 39 kDa receptor-associated protein low density lipoprotein receptor-related protein associated protein 1 low density lipoprotein-related protein-associated protein 1 (alpha-2-macroglobulin receptor-associated protein 1)
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 4 Map Location: 4p16.3
Summary	This gene encodes a protein that interacts with the low density lipoprotein (LDL) receptor-related protein and facilitates its proper folding and localization by preventing the binding of ligands. Mutations in this gene have been identified in individuals with myopia 23. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013].
Disorder MIM:	104225
Disorder Html:	Myopia 23, autosomal recessive, 615431 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_002337.3	NP_002328.1	alpha-2-macroglobulin receptor-associated protein precursor
NM_002337.4	NP_002328.1	alpha-2-macroglobulin receptor-associated protein precursor

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Lrpap1	NP_001162584.1
Danio rerio (zebrafish)	lrpap1	NP_958463.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP003521	XP_313261.4
Canis lupus familiaris (dog)	LRPAP1	XP_536218.3
Bos taurus (cattle)	LRPAP1	NP_001073694.1
Drosophila melanogaster (fruit fly)	CG8507	NP_649950.1
Xenopus tropicalis (tropical clawed frog)	lrpap1	NP_001090847.1
Homo sapiens (human)	LRPAP1	NP_002328.1
	LRPAP1	XP_001085674.1
Mus musculus (house mouse)	Lrpap1	NP_038615.2
Gallus gallus (chicken)	LRPAP1	NP_990393.1
Pan troglodytes (chimpanzee)	LRPAP1	NP_001233320.1

Gene Ontology
Bibliography

Related articles in PubMed

Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)

High Affinity Binding of the Receptor-associated Protein D1D2 Domains with the Low Density Lipoprotein Receptor-related Protein (LRP1) Involves Bivalent Complex Formation: CRITICAL ROLES OF LYSINES 60 AND 191.
Prasad JM, Young PA, Strickland DK
The Journal of biological chemistry291(35)18430-9(2016 08)

Clinical Characterization of LRPAP1-Related Pediatric High Myopia.
Khan AO, Aldahmesh MA, Alkuraya FS
Ophthalmology123(2)434-5(2016 Feb)

Central role for PICALM in amyloid-? blood-brain barrier transcytosis and clearance.
Zhao Z, Sagare AP, Ma Q, Halliday MR, Kong P, Kisler K, Winkler EA, Ramanathan A, Kanekiyo T, Bu G, Owens NC, Rege SV, Si G, Ahuja A, Zhu D, Miller CA, Schneider JA, Maeda M, Maeda T, Sugawara T, Ichida JK, Zlokovic BV
Nature neuroscience18(7)978-87(2015 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

data also reveal that D1D2 is able to bind to a second distinct site on LRP1 to form a monovalent complex. The studies confirm the canonical model for ligand recognition by this class of receptors, which is initiated by pairs of lysine residues that dock into acidic pockets on the receptor
Title: High Affinity Binding of the Receptor-associated Protein D1D2 Domains with the Low Density Lipoprotein Receptor-related Protein (LRP1) Involves Bivalent Complex Formation: CRITICAL ROLES OF LYSINES 60 AND 191.

The clinical and biometric features we describe in this report characterize LRPAP1-related high myopia and should raise suspicion for mutations in the gene.
Title: Clinical Characterization of LRPAP1-Related Pediatric High Myopia.

The inhibition caused by reagents that prevented the activation of Rap was reversed by mobilizing intracellular calcium pharmacologically, whereas that caused by acrosome reaction inhibitors that impeded Rab3's binding to GTP was not.
Title: Epac, Rap and Rab3 act in concert to mobilize calcium from sperm's acrosome during exocytosis.

The LRPAP1 I allelic variant may be considered a candidate gene for PD, predominantly in patients having the APOE epsilon4 allelic variant.
Title: APOE and LRPAP1 gene polymorphism and risk of Parkinson's disease.

RAP inhibited light chain (LC)endocytosis by approximately 88% and ameliorated LC-induced cytokine responses and epithelial-to-mesenchymal transformation in human proximal tubular cells.
Title: Receptor-associated protein blocks internalization and cytotoxicity of myeloma light chain in cultured human proximal tubular cells.

The following LRPAP1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the LRPAP1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu25194	NM_002337.4 Latest version!	Homo sapiens LDL receptor related protein associated protein 1 (LRPAP1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
View Old Accession Versions >>
OHu25194	NM_002337.3	Homo sapiens LDL receptor related protein associated protein 1 (LRPAP1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

LRPAP1 ( NM_002337.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_002328.1 Homo sapiens LDL receptor related protein associated protein 1 (LRPAP1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu25194
Clone ID Related Accession (Same CDS sequence)	NM_002337.3 , NM_002337.4
Accession Version	NM_002337.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1074bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	alpha-2-macroglobulin receptor-associated protein precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB035408.1, BC112067.1, BX647984.1, AK222504.1 and AL590235.23. This sequence is a reference standard in the RefSeqGene project. On Jun 22, 2011 this sequence version replaced NM_002337.2. Transcript Variant: This variant (1) represents the longer transcript and encodes the protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803611.170814.1, SRR1660807.257620.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2467146 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGCCGC GGAGGGTCAG GTCGTTTCTG CGCGGGCTCC CGGCGCTGCT ACTGCTGCTG 
CTCTTCCTCG GGCCCTGGCC CGCTGCGAGC CACGGCGGCA AGTACTCGCG GGAGAAGAAC 
CAGCCCAAGC CGTCCCCGAA ACGCGAGTCC GGAGAGGAGT TCCGCATGGA GAAGTTGAAC 
CAGCTGTGGG AGAAGGCCCA GCGACTGCAT CTTCCTCCCG TGAGGCTGGC CGAGCTCCAC 
GCTGATCTGA AGATACAGGA GAGGGACGAA CTCGCCTGGA AGAAACTAAA GCTTGACGGC 
TTGGACGAAG ATGGGGAGAA GGAAGCGAGA CTCATACGCA ACCTCAATGT CATCTTGGCC 
AAGTATGGTC TGGACGGAAA GAAGGACGCT CGGCAGGTGA CCAGCAACTC CCTCAGTGGC 
ACCCAGGAAG ACGGGCTGGA TGACCCCAGG CTGGAAAAGC TGTGGCACAA GGCGAAGACC 
TCTGGGAAAT TCTCCGGCGA AGAACTGGAC AAGCTCTGGC GGGAGTTCCT GCATCACAAA 
GAGAAAGTTC ACGAGTACAA CGTCCTGCTG GAGACCCTGA GCAGGACCGA AGAAATCCAC 
GAGAACGTCA TTAGCCCCTC GGACCTGAGC GACATCAAGG GCAGCGTCCT GCACAGCAGG 
CACACGGAGC TGAAGGAGAA GCTGCGCAGC ATCAACCAGG GCCTGGACCG CCTGCGCAGG 
GTCAGCCACC AGGGCTACAG CACTGAGGCT GAGTTCGAGG AGCCCAGGGT GATTGACCTG 
TGGGACCTGG CGCAGTCCGC CAACCTCACG GACAAGGAGC TGGAGGCGTT CCGGGAGGAG 
CTCAAGCACT TCGAAGCCAA AATCGAGAAG CACAACCACT ACCAGAAGCA GCTGGAGATT 
GCGCACGAGA AGCTGAGGCA CGCAGAGAGC GTGGGCGACG GCGAGCGTGT GAGCCGCAGC 
CGCGAGAAGC ACGCCCTGCT GGAGGGGCGG ACCAAGGAGC TGGGCTACAC GGTGAAGAAG 
CATCTGCAGG ACCTGTCCGG CAGGATCTCC AGAGCTCGGC ACAACGAACT CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002328.1
CDS	86..1159
Translation	MAPRRVRSFLRGLPALLLLLLFLGPWPAASHGGKYSREKNQPKPSPKRESGEEFRMEKLNQLWEKAQRLHLPPVRLAELHADLKIQERDELAWKKLKLDGLDEDGEKEARLIRNLNVILAKYGLDGKKDARQVTSNSLSGTQEDGLDDPRLEKLWHKAKTSGKFSGEELDKLWREFLHHKEKVHEYNVLLETLSRTEEIHENVISPSDLSDIKGSVLHSRHTELKEKLRSINQGLDRLRRVSHQGYSTEAEFEEPRVIDLWDLAQSANLTDKELEAFREELKHFEAKIEKHNHYQKQLEIAHEKLRHAESVGDGERVSRSREKHALLEGRTKELGYTVKKHLQDLSGRISRARHNEL

Target ORF information:

RefSeq Version	NM_002337.3
Organism	Homo sapiens(human)
Definition	Homo sapiens LDL receptor related protein associated protein 1 (LRPAP1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002337.3

ORF Insert Sequence:

ATGGCGCCGC GGAGGGTCAG GTCGTTTCTG CGCGGGCTCC CGGCGCTGCT ACTGCTGCTG 
CTCTTCCTCG GGCCCTGGCC CGCTGCGAGC CACGGCGGCA AGTACTCGCG GGAGAAGAAC 
CAGCCCAAGC CGTCCCCGAA ACGCGAGTCC GGAGAGGAGT TCCGCATGGA GAAGTTGAAC 
CAGCTGTGGG AGAAGGCCCA GCGACTGCAT CTTCCTCCCG TGAGGCTGGC CGAGCTCCAC 
GCTGATCTGA AGATACAGGA GAGGGACGAA CTCGCCTGGA AGAAACTAAA GCTTGACGGC 
TTGGACGAAG ATGGGGAGAA GGAAGCGAGA CTCATACGCA ACCTCAATGT CATCTTGGCC 
AAGTATGGTC TGGACGGAAA GAAGGACGCT CGGCAGGTGA CCAGCAACTC CCTCAGTGGC 
ACCCAGGAAG ACGGGCTGGA TGACCCCAGG CTGGAAAAGC TGTGGCACAA GGCGAAGACC 
TCTGGGAAAT TCTCCGGCGA AGAACTGGAC AAGCTCTGGC GGGAGTTCCT GCATCACAAA 
GAGAAAGTTC ACGAGTACAA CGTCCTGCTG GAGACCCTGA GCAGGACCGA AGAAATCCAC 
GAGAACGTCA TTAGCCCCTC GGACCTGAGC GACATCAAGG GCAGCGTCCT GCACAGCAGG 
CACACGGAGC TGAAGGAGAA GCTGCGCAGC ATCAACCAGG GCCTGGACCG CCTGCGCAGG 
GTCAGCCACC AGGGCTACAG CACTGAGGCT GAGTTCGAGG AGCCCAGGGT GATTGACCTG 
TGGGACCTGG CGCAGTCCGC CAACCTCACG GACAAGGAGC TGGAGGCGTT CCGGGAGGAG 
CTCAAGCACT TCGAAGCCAA AATCGAGAAG CACAACCACT ACCAGAAGCA GCTGGAGATT 
GCGCACGAGA AGCTGAGGCA CGCAGAGAGC GTGGGCGACG GCGAGCGTGT GAGCCGCAGC 
CGCGAGAAGC ACGCCCTGCT GGAGGGGCGG ACCAAGGAGC TGGGCTACAC GGTGAAGAAG 
CATCTGCAGG ACCTGTCCGG CAGGATCTCC AGAGCTCGGC ACAACGAACT CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

LRPAP1 ( NM_002337.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_002328.1 Homo sapiens LDL receptor related protein associated protein 1 (LRPAP1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu25194
Clone ID Related Accession (Same CDS sequence)	NM_002337.3 , NM_002337.4
Accession Version	NM_002337.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1074bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-10
Organism	Homo sapiens(human)
Product	alpha-2-macroglobulin receptor-associated protein precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB035408.1, BC112067.1, BX647984.1, AK222504.1 and AL590235.23. This sequence is a reference standard in the RefSeqGene project. On Oct 23, 2018 this sequence version replaced NM_002337.3. Transcript Variant: This variant (1) represents the longer transcript and encodes the protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660807.257620.1, SRR1803613.284814.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2467146 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000650182.1/ ENSP00000497444.1 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCGCCGC GGAGGGTCAG GTCGTTTCTG CGCGGGCTCC CGGCGCTGCT ACTGCTGCTG 
CTCTTCCTCG GGCCCTGGCC CGCTGCGAGC CACGGCGGCA AGTACTCGCG GGAGAAGAAC 
CAGCCCAAGC CGTCCCCGAA ACGCGAGTCC GGAGAGGAGT TCCGCATGGA GAAGTTGAAC 
CAGCTGTGGG AGAAGGCCCA GCGACTGCAT CTTCCTCCCG TGAGGCTGGC CGAGCTCCAC 
GCTGATCTGA AGATACAGGA GAGGGACGAA CTCGCCTGGA AGAAACTAAA GCTTGACGGC 
TTGGACGAAG ATGGGGAGAA GGAAGCGAGA CTCATACGCA ACCTCAATGT CATCTTGGCC 
AAGTATGGTC TGGACGGAAA GAAGGACGCT CGGCAGGTGA CCAGCAACTC CCTCAGTGGC 
ACCCAGGAAG ACGGGCTGGA TGACCCCAGG CTGGAAAAGC TGTGGCACAA GGCGAAGACC 
TCTGGGAAAT TCTCCGGCGA AGAACTGGAC AAGCTCTGGC GGGAGTTCCT GCATCACAAA 
GAGAAAGTTC ACGAGTACAA CGTCCTGCTG GAGACCCTGA GCAGGACCGA AGAAATCCAC 
GAGAACGTCA TTAGCCCCTC GGACCTGAGC GACATCAAGG GCAGCGTCCT GCACAGCAGG 
CACACGGAGC TGAAGGAGAA GCTGCGCAGC ATCAACCAGG GCCTGGACCG CCTGCGCAGG 
GTCAGCCACC AGGGCTACAG CACTGAGGCT GAGTTCGAGG AGCCCAGGGT GATTGACCTG 
TGGGACCTGG CGCAGTCCGC CAACCTCACG GACAAGGAGC TGGAGGCGTT CCGGGAGGAG 
CTCAAGCACT TCGAAGCCAA AATCGAGAAG CACAACCACT ACCAGAAGCA GCTGGAGATT 
GCGCACGAGA AGCTGAGGCA CGCAGAGAGC GTGGGCGACG GCGAGCGTGT GAGCCGCAGC 
CGCGAGAAGC ACGCCCTGCT GGAGGGGCGG ACCAAGGAGC TGGGCTACAC GGTGAAGAAG 
CATCTGCAGG ACCTGTCCGG CAGGATCTCC AGAGCTCGGC ACAACGAACT CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002328.1
CDS	11..1084
Translation	MAPRRVRSFLRGLPALLLLLLFLGPWPAASHGGKYSREKNQPKPSPKRESGEEFRMEKLNQLWEKAQRLHLPPVRLAELHADLKIQERDELAWKKLKLDGLDEDGEKEARLIRNLNVILAKYGLDGKKDARQVTSNSLSGTQEDGLDDPRLEKLWHKAKTSGKFSGEELDKLWREFLHHKEKVHEYNVLLETLSRTEEIHENVISPSDLSDIKGSVLHSRHTELKEKLRSINQGLDRLRRVSHQGYSTEAEFEEPRVIDLWDLAQSANLTDKELEAFREELKHFEAKIEKHNHYQKQLEIAHEKLRHAESVGDGERVSRSREKHALLEGRTKELGYTVKKHLQDLSGRISRARHNEL

Target ORF information:

RefSeq Version	NM_002337.4
Organism	Homo sapiens(human)
Definition	Homo sapiens LDL receptor related protein associated protein 1 (LRPAP1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002337.4

ORF Insert Sequence:

ATGGCGCCGC GGAGGGTCAG GTCGTTTCTG CGCGGGCTCC CGGCGCTGCT ACTGCTGCTG 
CTCTTCCTCG GGCCCTGGCC CGCTGCGAGC CACGGCGGCA AGTACTCGCG GGAGAAGAAC 
CAGCCCAAGC CGTCCCCGAA ACGCGAGTCC GGAGAGGAGT TCCGCATGGA GAAGTTGAAC 
CAGCTGTGGG AGAAGGCCCA GCGACTGCAT CTTCCTCCCG TGAGGCTGGC CGAGCTCCAC 
GCTGATCTGA AGATACAGGA GAGGGACGAA CTCGCCTGGA AGAAACTAAA GCTTGACGGC 
TTGGACGAAG ATGGGGAGAA GGAAGCGAGA CTCATACGCA ACCTCAATGT CATCTTGGCC 
AAGTATGGTC TGGACGGAAA GAAGGACGCT CGGCAGGTGA CCAGCAACTC CCTCAGTGGC 
ACCCAGGAAG ACGGGCTGGA TGACCCCAGG CTGGAAAAGC TGTGGCACAA GGCGAAGACC 
TCTGGGAAAT TCTCCGGCGA AGAACTGGAC AAGCTCTGGC GGGAGTTCCT GCATCACAAA 
GAGAAAGTTC ACGAGTACAA CGTCCTGCTG GAGACCCTGA GCAGGACCGA AGAAATCCAC 
GAGAACGTCA TTAGCCCCTC GGACCTGAGC GACATCAAGG GCAGCGTCCT GCACAGCAGG 
CACACGGAGC TGAAGGAGAA GCTGCGCAGC ATCAACCAGG GCCTGGACCG CCTGCGCAGG 
GTCAGCCACC AGGGCTACAG CACTGAGGCT GAGTTCGAGG AGCCCAGGGT GATTGACCTG 
TGGGACCTGG CGCAGTCCGC CAACCTCACG GACAAGGAGC TGGAGGCGTT CCGGGAGGAG 
CTCAAGCACT TCGAAGCCAA AATCGAGAAG CACAACCACT ACCAGAAGCA GCTGGAGATT 
GCGCACGAGA AGCTGAGGCA CGCAGAGAGC GTGGGCGACG GCGAGCGTGT GAGCCGCAGC 
CGCGAGAAGC ACGCCCTGCT GGAGGGGCGG ACCAAGGAGC TGGGCTACAC GGTGAAGAAG 
CATCTGCAGG ACCTGTCCGG CAGGATCTCC AGAGCTCGGC ACAACGAACT CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Architecture of the human interactome defines protein communities and disease networks.
Nature545(7655)505-509(2017 05)
Huttlin EL,Bruckner RJ,Paulo JA,Cannon JR,Ting L,Baltier K,Colby G,Gebreab F,Gygi MP,Parzen H,Szpyt J,Tam S,Zarraga G,Pontano-Vaites L,Swarup S,White AE,Schweppe DK,Rad R,Erickson BK,Obar RA,Guruharsha KG,Li K,Artavanis-Tsakonas S,Gygi SP,Harper JW

High Affinity Binding of the Receptor-associated Protein D1D2 Domains with the Low Density Lipoprotein Receptor-related Protein (LRP1) Involves Bivalent Complex Formation: CRITICAL ROLES OF LYSINES 60 AND 191.
The Journal of biological chemistry291(35)18430-9(2016 08)
Prasad JM,Young PA,Strickland DK

Clinical Characterization of LRPAP1-Related Pediatric High Myopia.
Ophthalmology123(2)434-5(2016 Feb)
Khan AO,Aldahmesh MA,Alkuraya FS

Central role for PICALM in amyloid-? blood-brain barrier transcytosis and clearance.
Nature neuroscience18(7)978-87(2015 Jul)
Zhao Z,Sagare AP,Ma Q,Halliday MR,Kong P,Kisler K,Winkler EA,Ramanathan A,Kanekiyo T,Bu G,Owens NC,Rege SV,Si G,Ahuja A,Zhu D,Miller CA,Schneider JA,Maeda M,Maeda T,Sugawara T,Ichida JK,Zlokovic BV

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LRPAP1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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