YY2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	YY2
Entrez Gene ID	404281
Full Name	YY2 transcription factor
Synonyms	ZNF631
General protein information	Preferred Names YY2 transcription factor Names transcription factor YY2 transcription factor yin yang 2 yin and yang 2 zinc finger protein 631
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: X Map Location: Xp22.12
Summary	The protein encoded by this gene is a transcription factor that includes several Kruppel-like zinc fingers in its C-terminal region. It possesses both activation and repression domains, and it can therefore have both positive and negative effects on the transcription of target genes. This gene has an intronless coding region, and it appears to have arisen by retrotransposition of the related YY1 transcription factor gene, which is located on chromosome 14. [provided by RefSeq, May 2010].
Disorder MIM:	300570

mRNA and Protein(s)

mRNA	Protein	Name
NM_206923.3	NP_996806.2	transcription factor YY2
NM_206923.4	NP_996806.2	transcription factor YY2

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	YY2	XP_529235.2
Canis lupus familiaris (dog)	LOC102152457	XP_005641250.1
Homo sapiens (human)	YY2	NP_996806.2
Mus musculus (house mouse)	Yy2	NP_001092193.1
	LOC696656	XP_001087143.1

Gene Ontology
Bibliography

Related articles in PubMed

Expression of metastasis suppressor gene AES driven by a Yin Yang (YY) element in a CpG island promoter and transcription factor YY2.
Kakizaki F, Sonoshita M, Miyoshi H, Itatani Y, Ito S, Kawada K, Sakai Y, Taketo MM
Cancer science107(11)1622-1631(2016 Nov)

DNA-binding specificities of human transcription factors.
Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J
Cell152(1-2)327-39(2013 Jan)

Yin Yang 2: the great unknown within the Yin Yang 1 regulatory network.
Klar M
Critical reviews in oncogenesis16(3-4)239-43(2011)

Genome-wide analysis of YY2 versus YY1 target genes.
Chen L, Shioda T, Coser KR, Lynch MC, Yang C, Schmidt EV
Nucleic acids research38(12)4011-26(2010 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

In human colorectal cancer metastases to the liver, the levels of AES protein are correlated with those of YY2
Title: Expression of metastasis suppressor gene AES driven by a Yin Yang (YY) element in a CpG island promoter and transcription factor YY2.

article summarizes all critical aspects that are (or will be) relevant for a better understanding of YY1- and/or YY2-mediated cellular control mechanisms
Title: Yin Yang 2: the great unknown within the Yin Yang 1 regulatory network.

Results show that human YY2 is not redundant to YY1, and YY2 is a significant regulator of genes previously identified as uniquely responding to YY1.
Title: Genome-wide analysis of YY2 versus YY1 target genes.

yy2 expression is mediated by its own methylation-sensitive promoter.
Title: Transcriptional activity of the novel identified human yy2 promoter is modified by DNA methylation.

the novel factor YY2 antagonizes the negative actions exerted by YY1
Title: Enhanceosome formation over the beta interferon promoter underlies a remote-control mechanism mediated by YY1 and YY2.

The following YY2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the YY2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu19012	NM_206923.4 Latest version!	Homo sapiens YY2 transcription factor (YY2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
View Old Accession Versions >>
OHu19012	NM_206923.3	Homo sapiens YY2 transcription factor (YY2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

YY2 ( NM_206923.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_996806.2 Homo sapiens YY2 transcription factor (YY2), mRNA.

Price & Availability↑

CloneID	OHu19012
Clone ID Related Accession (Same CDS sequence)	NM_206923.3 , NM_206923.4
Accession Version	NM_206923.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1119bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-06-23
Organism	Homo sapiens(human)
Product	transcription factor YY2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK091850.1, DB029513.1, DB459498.2 and BC137215.1. This sequence is a reference standard in the RefSeqGene project. On May 13, 2010 this sequence version replaced NM_206923.2. ##Evidence-Data-START## Transcript is intronless :: AK091850.1 [ECO:0000345] ##Evidence-Data-END##

ATGGCCTCCA ACGAAGATTT CTCCATCACA CAAGACCTGG AGATCCCGGC AGATATTGTG 
GAGCTCCACG ACATCAATGT GGAGCCCCTT CCTATGGAGG ACATTCCGAC GGAAAGCGTC 
CAGTACGAGG ATGTGGATGG CAATTGGATC TACGGTGGCC ACAACCATCC GCCATTGATG 
GTGTTGCAGC CGCTCTTCAC GAACACGGGC TATGGCGACC ACGACCAGGA AATGCTTATG 
TTGCAGACAC AAGAGGAAGT GGTGGGCTAT TGCGACTCAG ACAACCAGCT AGGCAACGAC 
TTGGAGGACC AGTTGGCCCT CCCGGATAGC ATTGAAGACG AGCACTTCCA GATGACCCTG 
GCCTCTCTGT CGGCCTCGGC GGCATCAACA TCAACATCAA CCCAGAGCCG CAGCAAAAAG 
CCCAGCAAAA AGCCCAGCGG CAAGAGTGCC ACCAGCACTG AGGCCAACCC GGCAGGCAGC 
AGCTCCAGCC TGGGCACGAG GAAGTGGGAG CAGAAGCAAA TGCAGGTCAA AACGCTGGAG 
GGTGAGTTTT CCGTGACTAT GTGGTCCCCT AACGATAACA ATGACCAAGG GGCAGTGGGT 
GAAGGCCAGG CTGAAAACCC ACCTGATTAT TCCGAGTACT TGAAAGGGAA GAAACTTCCT 
CCTGGGGGGT TACCAGGCAT TGATCTCTCA GATCCTAAAC AGCTGGCAGA ATTTACTAAA 
GTGAAGCCCA AAAGGTCCAA AGGAGAACCT CCCAAAACAG TCCCTTGCTC TTATAGCGGC 
TGCGAAAAGA TGTTCCGGGA TTACGCCGCC ATGAGAAAAC ATCTCCACAT CCACGGGCCC 
AGAGTCCACG TATGTGCAGA ATGTGGCAAA GCTTTTCTTG AGAGCTCAAA GCTGAGACGA 
CACCAGCTGG TCCACACCGG CGAGAAGCCC TTTCAGTGCA CATTCGAAGG CTGCGGGAAA 
CGCTTTTCCC TTGATTTCAA TTTGCGCACA CACTTGCGCA TCCACACCGG CGATAAGCCC 
TTCGTGTGCC CCTTCGATGT TTGCAACAGG AAGTTCGCTC AGTCAACCAA CCTGAAAACC 
CACATATTAA CGCATGTGAA GACCAAAAAC AACCCGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_996806.2
CDS	499..1617
Translation	MASNEDFSITQDLEIPADIVELHDINVEPLPMEDIPTESVQYEDVDGNWIYGGHNHPPLMVLQPLFTNTGYGDHDQEMLMLQTQEEVVGYCDSDNQLGNDLEDQLALPDSIEDEHFQMTLASLSASAASTSTSTQSRSKKPSKKPSGKSATSTEANPAGSSSSLGTRKWEQKQMQVKTLEGEFSVTMWSPNDNNDQGAVGEGQAENPPDYSEYLKGKKLPPGGLPGIDLSDPKQLAEFTKVKPKRSKGEPPKTVPCSYSGCEKMFRDYAAMRKHLHIHGPRVHVCAECGKAFLESSKLRRHQLVHTGEKPFQCTFEGCGKRFSLDFNLRTHLRIHTGDKPFVCPFDVCNRKFAQSTNLKTHILTHVKTKNNP

Target ORF information:

RefSeq Version	NM_206923.3
Organism	Homo sapiens(human)
Definition	Homo sapiens YY2 transcription factor (YY2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_206923.3

ORF Insert Sequence:

ATGGCCTCCA ACGAAGATTT CTCCATCACA CAAGACCTGG AGATCCCGGC AGATATTGTG 
GAGCTCCACG ACATCAATGT GGAGCCCCTT CCTATGGAGG ACATTCCGAC GGAAAGCGTC 
CAGTACGAGG ATGTGGATGG CAATTGGATC TACGGTGGCC ACAACCATCC GCCATTGATG 
GTGTTGCAGC CGCTCTTCAC GAACACGGGC TATGGCGACC ACGACCAGGA AATGCTTATG 
TTGCAGACAC AAGAGGAAGT GGTGGGCTAT TGCGACTCAG ACAACCAGCT AGGCAACGAC 
TTGGAGGACC AGTTGGCCCT CCCGGATAGC ATTGAAGACG AGCACTTCCA GATGACCCTG 
GCCTCTCTGT CGGCCTCGGC GGCATCAACA TCAACATCAA CCCAGAGCCG CAGCAAAAAG 
CCCAGCAAAA AGCCCAGCGG CAAGAGTGCC ACCAGCACTG AGGCCAACCC GGCAGGCAGC 
AGCTCCAGCC TGGGCACGAG GAAGTGGGAG CAGAAGCAAA TGCAGGTCAA AACGCTGGAG 
GGTGAGTTTT CCGTGACTAT GTGGTCCCCT AACGATAACA ATGACCAAGG GGCAGTGGGT 
GAAGGCCAGG CTGAAAACCC ACCTGATTAT TCCGAGTACT TGAAAGGGAA GAAACTTCCT 
CCTGGGGGGT TACCAGGCAT TGATCTCTCA GATCCTAAAC AGCTGGCAGA ATTTACTAAA 
GTGAAGCCCA AAAGGTCCAA AGGAGAACCT CCCAAAACAG TCCCTTGCTC TTATAGCGGC 
TGCGAAAAGA TGTTCCGGGA TTACGCCGCC ATGAGAAAAC ATCTCCACAT CCACGGGCCC 
AGAGTCCACG TATGTGCAGA ATGTGGCAAA GCTTTTCTTG AGAGCTCAAA GCTGAGACGA 
CACCAGCTGG TCCACACCGG CGAGAAGCCC TTTCAGTGCA CATTCGAAGG CTGCGGGAAA 
CGCTTTTCCC TTGATTTCAA TTTGCGCACA CACTTGCGCA TCCACACCGG CGATAAGCCC 
TTCGTGTGCC CCTTCGATGT TTGCAACAGG AAGTTCGCTC AGTCAACCAA CCTGAAAACC 
CACATATTAA CGCATGTGAA GACCAAAAAC AACCCGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

YY2 ( NM_206923.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_996806.2 Homo sapiens YY2 transcription factor (YY2), mRNA.

Price & Availability↑

CloneID	OHu19012
Clone ID Related Accession (Same CDS sequence)	NM_206923.3 , NM_206923.4
Accession Version	NM_206923.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1119bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-20
Organism	Homo sapiens(human)
Product	transcription factor YY2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK091850.1, DB029513.1, DB459498.2, BC137215.1 and U73479.1. This sequence is a reference standard in the RefSeqGene project. On May 17, 2019 this sequence version replaced NM_206923.3. ##Evidence-Data-START## Transcript is intronless :: AK091850.1, SRR1803615.229321.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000429584.3/ ENSP00000389381.2 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGGCCTCCA ACGAAGATTT CTCCATCACA CAAGACCTGG AGATCCCGGC AGATATTGTG 
GAGCTCCACG ACATCAATGT GGAGCCCCTT CCTATGGAGG ACATTCCGAC GGAAAGCGTC 
CAGTACGAGG ATGTGGATGG CAATTGGATC TACGGTGGCC ACAACCATCC GCCATTGATG 
GTGTTGCAGC CGCTCTTCAC GAACACGGGC TATGGCGACC ACGACCAGGA AATGCTTATG 
TTGCAGACAC AAGAGGAAGT GGTGGGCTAT TGCGACTCAG ACAACCAGCT AGGCAACGAC 
TTGGAGGACC AGTTGGCCCT CCCGGATAGC ATTGAAGACG AGCACTTCCA GATGACCCTG 
GCCTCTCTGT CGGCCTCGGC GGCATCAACA TCAACATCAA CCCAGAGCCG CAGCAAAAAG 
CCCAGCAAAA AGCCCAGCGG CAAGAGTGCC ACCAGCACTG AGGCCAACCC GGCAGGCAGC 
AGCTCCAGCC TGGGCACGAG GAAGTGGGAG CAGAAGCAAA TGCAGGTCAA AACGCTGGAG 
GGTGAGTTTT CCGTGACTAT GTGGTCCCCT AACGATAACA ATGACCAAGG GGCAGTGGGT 
GAAGGCCAGG CTGAAAACCC ACCTGATTAT TCCGAGTACT TGAAAGGGAA GAAACTTCCT 
CCTGGGGGGT TACCAGGCAT TGATCTCTCA GATCCTAAAC AGCTGGCAGA ATTTACTAAA 
GTGAAGCCCA AAAGGTCCAA AGGAGAACCT CCCAAAACAG TCCCTTGCTC TTATAGCGGC 
TGCGAAAAGA TGTTCCGGGA TTACGCCGCC ATGAGAAAAC ATCTCCACAT CCACGGGCCC 
AGAGTCCACG TATGTGCAGA ATGTGGCAAA GCTTTTCTTG AGAGCTCAAA GCTGAGACGA 
CACCAGCTGG TCCACACCGG CGAGAAGCCC TTTCAGTGCA CATTCGAAGG CTGCGGGAAA 
CGCTTTTCCC TTGATTTCAA TTTGCGCACA CACTTGCGCA TCCACACCGG CGATAAGCCC 
TTCGTGTGCC CCTTCGATGT TTGCAACAGG AAGTTCGCTC AGTCAACCAA CCTGAAAACC 
CACATATTAA CGCATGTGAA GACCAAAAAC AACCCGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_996806.2
CDS	499..1617
Translation	MASNEDFSITQDLEIPADIVELHDINVEPLPMEDIPTESVQYEDVDGNWIYGGHNHPPLMVLQPLFTNTGYGDHDQEMLMLQTQEEVVGYCDSDNQLGNDLEDQLALPDSIEDEHFQMTLASLSASAASTSTSTQSRSKKPSKKPSGKSATSTEANPAGSSSSLGTRKWEQKQMQVKTLEGEFSVTMWSPNDNNDQGAVGEGQAENPPDYSEYLKGKKLPPGGLPGIDLSDPKQLAEFTKVKPKRSKGEPPKTVPCSYSGCEKMFRDYAAMRKHLHIHGPRVHVCAECGKAFLESSKLRRHQLVHTGEKPFQCTFEGCGKRFSLDFNLRTHLRIHTGDKPFVCPFDVCNRKFAQSTNLKTHILTHVKTKNNP

Target ORF information:

RefSeq Version	NM_206923.4
Organism	Homo sapiens(human)
Definition	Homo sapiens YY2 transcription factor (YY2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_206923.4

ORF Insert Sequence:

ATGGCCTCCA ACGAAGATTT CTCCATCACA CAAGACCTGG AGATCCCGGC AGATATTGTG 
GAGCTCCACG ACATCAATGT GGAGCCCCTT CCTATGGAGG ACATTCCGAC GGAAAGCGTC 
CAGTACGAGG ATGTGGATGG CAATTGGATC TACGGTGGCC ACAACCATCC GCCATTGATG 
GTGTTGCAGC CGCTCTTCAC GAACACGGGC TATGGCGACC ACGACCAGGA AATGCTTATG 
TTGCAGACAC AAGAGGAAGT GGTGGGCTAT TGCGACTCAG ACAACCAGCT AGGCAACGAC 
TTGGAGGACC AGTTGGCCCT CCCGGATAGC ATTGAAGACG AGCACTTCCA GATGACCCTG 
GCCTCTCTGT CGGCCTCGGC GGCATCAACA TCAACATCAA CCCAGAGCCG CAGCAAAAAG 
CCCAGCAAAA AGCCCAGCGG CAAGAGTGCC ACCAGCACTG AGGCCAACCC GGCAGGCAGC 
AGCTCCAGCC TGGGCACGAG GAAGTGGGAG CAGAAGCAAA TGCAGGTCAA AACGCTGGAG 
GGTGAGTTTT CCGTGACTAT GTGGTCCCCT AACGATAACA ATGACCAAGG GGCAGTGGGT 
GAAGGCCAGG CTGAAAACCC ACCTGATTAT TCCGAGTACT TGAAAGGGAA GAAACTTCCT 
CCTGGGGGGT TACCAGGCAT TGATCTCTCA GATCCTAAAC AGCTGGCAGA ATTTACTAAA 
GTGAAGCCCA AAAGGTCCAA AGGAGAACCT CCCAAAACAG TCCCTTGCTC TTATAGCGGC 
TGCGAAAAGA TGTTCCGGGA TTACGCCGCC ATGAGAAAAC ATCTCCACAT CCACGGGCCC 
AGAGTCCACG TATGTGCAGA ATGTGGCAAA GCTTTTCTTG AGAGCTCAAA GCTGAGACGA 
CACCAGCTGG TCCACACCGG CGAGAAGCCC TTTCAGTGCA CATTCGAAGG CTGCGGGAAA 
CGCTTTTCCC TTGATTTCAA TTTGCGCACA CACTTGCGCA TCCACACCGG CGATAAGCCC 
TTCGTGTGCC CCTTCGATGT TTGCAACAGG AAGTTCGCTC AGTCAACCAA CCTGAAAACC 
CACATATTAA CGCATGTGAA GACCAAAAAC AACCCGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Expression of metastasis suppressor gene AES driven by a Yin Yang (YY) element in a CpG island promoter and transcription factor YY2.
Cancer science107(11)1622-1631(2016 Nov)
Kakizaki F,Sonoshita M,Miyoshi H,Itatani Y,Ito S,Kawada K,Sakai Y,Taketo MM

DNA-binding specificities of human transcription factors.
Cell152(1-2)327-39(2013 Jan)
Jolma A,Yan J,Whitington T,Toivonen J,Nitta KR,Rastas P,Morgunova E,Enge M,Taipale M,Wei G,Palin K,Vaquerizas JM,Vincentelli R,Luscombe NM,Hughes TR,Lemaire P,Ukkonen E,Kivioja T,Taipale J

Yin Yang 2: the great unknown within the Yin Yang 1 regulatory network.
Critical reviews in oncogenesis16(3-4)239-43(2011)
Klar M

Genome-wide analysis of YY2 versus YY1 target genes.
Nucleic acids research38(12)4011-26(2010 Jul)
Chen L,Shioda T,Coser KR,Lynch MC,Yang C,Schmidt EV

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YY2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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