PHOX2A cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	PHOX2A
Entrez Gene ID	401
Full Name	paired like homeobox 2a
Synonyms	ARIX,CFEOM2,FEOM2,NCAM2,PMX2A
General protein information	Preferred Names paired like homeobox 2a Names paired mesoderm homeobox protein 2A ARIX1 homeodomain protein aristaless homeobox homolog aristaless homeobox protein homolog arix homeodomain protein paired-like homeobox 2A
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 11 Map Location: 11q13.4
Summary	The protein encoded by this gene contains a paired-like homeodomain most similar to that of the Drosophila aristaless gene product. The encoded protein plays a central role in development of the autonomic nervous system. It regulates the expression of tyrosine hydroxylase and dopamine beta-hydroxylase, two catecholaminergic biosynthetic enzymes essential for the differentiation and maintenance of the noradrenergic neurotransmitter phenotype. The encoded protein has also been shown to regulate transcription of the alpha3 nicotinic acetylcholine receptor gene. Mutations in this gene have been associated with autosomal recessive congenital fibrosis of the extraocular muscles. [provided by RefSeq, Jul 2008].
Disorder MIM:	602753
Disorder Html:	Fibrosis of extraocular muscles, congenital, 2, 602078 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_005169.4	NP_005160.2	paired mesoderm homeobox protein 2A
NM_005169.3	NP_005160.2	paired mesoderm homeobox protein 2A

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Phox2a	NP_446321.1
Danio rerio (zebrafish)	phox2a	NP_996953.1
Mus musculus (house mouse)	Phox2a	NP_032913.1
Xenopus tropicalis (tropical clawed frog)	phox2a	NP_001239128.1
Homo sapiens (human)	PHOX2A	NP_005160.2
Canis lupus familiaris (dog)	PHOX2A	XP_542326.2
Bos taurus (cattle)	PHOX2A	NP_001179086.1

Gene Ontology
Bibliography

Related articles in PubMed

PHOX2A and PHOX2B are differentially regulated during retinoic acid-driven differentiation of SK-N-BE(2)C neuroblastoma cell line.
Di Lascio S, Saba E, Belperio D, Raimondi A, Lucchetti H, Fornasari D, Benfante R
Experimental cell research342(1)62-71(2016 Mar)

Phenotype-phenotype and genotype-phenotype correlations in patients with idiopathic superior oblique muscle palsy.
Ohkubo SI, Matsuo T, Hasebe K, Shira YH, Itoshima E, Ohtsuki H
Journal of human genetics57(2)122-9(2012 Feb)

[Identification of a novel PHOX2A gene mutation in a Chinese family with congenital fibrosis of extraocular muscles type 2].
Dong JM, Shen Q, Li J, Du W, Pang HL, Lin SF, Bu J
Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics29(1)5-8(2012 Feb)

Mutations in KIF21A and PHOX2A are absent in 16 patients with congenital vertical incomitant strabismus.
Khan AO, Khalil DS, Al-Sharif LJ, Al-Tassan NA
Ophthalmic genetics30(4)206-7(2009 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

PHOX2A expression is finely controlled during retinoic acid differentiation and this, together with PHOX2B down-regulation.
Title: PHOX2A and PHOX2B are differentially regulated during retinoic acid-driven differentiation of SK-N-BE(2)C neuroblastoma cell line.

Patients with ARIX and/or PHOX2B polymorphisms had less hypoplastic superior oblique muscles.
Title: Phenotype-phenotype and genotype-phenotype correlations in patients with idiopathic superior oblique muscle palsy.

Genetic linkage was found at 11q13 between D11S4151 and D11S1320 and the PHOX2A gene.
Title: [Identification of a novel PHOX2A gene mutation in a Chinese family with congenital fibrosis of extraocular muscles type 2].

Our 16-patient sample suggests that KIF21A and PHOX2A sequence variation does not have a role in common forms of congenital incomitant vertical strabismus.
Title: Mutations in KIF21A and PHOX2A are absent in 16 patients with congenital vertical incomitant strabismus.

Transfection of Phox2a cDNA significantly increases mRNA and protein levels of norepinephrine transporter and dopamine beta-hydroxylase.
Title: Effects of transcription factors Phox2 on expression of norepinephrine transporter and dopamine beta-hydroxylase in SK-N-BE(2)C cells.

The following PHOX2A gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PHOX2A cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu18020	NM_005169.4 Latest version!	Homo sapiens paired like homeobox 2A (PHOX2A), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00
View Old Accession Versions >>
OHu18020	NM_005169.3	Homo sapiens paired like homeobox 2a (PHOX2A), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00
Hide Old Accession Versions >>

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

PHOX2A ( NM_005169.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_005160.2 Homo sapiens paired like homeobox 2A (PHOX2A), mRNA.

Price & Availability↑

CloneID	OHu18020
Clone ID Related Accession (Same CDS sequence)	NM_005169.4 , NM_005169.3
Accession Version	NM_005169.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 855bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-21
Organism	Homo sapiens(human)
Product	paired mesoderm homeobox protein 2A
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK290645.1 and BC041564.1. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_005169.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC041564.1, BX376662.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1968968 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000298231.5/ ENSP00000298231.5 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGACTACT CCTACCTCAA TTCGTACGAC TCGTGCGTGG CGGCCATGGA GGCGTCCGCC 
TACGGCGACT TTGGCGCCTG CAGCCAGCCC GGCGGCTTCC AATACAGCCC CCTGCGGCCC 
GCTTTCCCCG CGGCAGGGCC GCCCTGCCCC GCGCTCGGCT CCTCCAACTG CGCACTTGGC 
GCCCTACGCG ACCACCAGCC CGCGCCCTAC TCGGCAGTGC CCTACAAGTT CTTCCCAGAG 
CCATCCGGCC TGCACGAGAA GCGCAAGCAG CGGCGCATCC GCACCACGTT CACCAGCGCG 
CAGCTCAAGG AGCTGGAGCG CGTTTTCGCT GAGACCCACT ACCCCGACAT TTACACGCGT 
GAGGAGCTGG CGCTCAAGAT CGACCTCACT GAGGCTCGCG TGCAGGTCTG GTTCCAGAAC 
CGCCGGGCCA AGTTCCGCAA ACAGGAGCGC GCGGCCAGCG CCAAGGGCGC GGCGGGCGCG 
GCGGGCGCCA AAAAGGGCGA GGCGCGCTGC TCCTCCGAGG ACGACGATTC CAAGGAGTCC 
ACGTGCAGCC CCACGCCCGA TAGCACCGCC TCGCTGCCGC CGCCGCCTGC GCCCGGCCTG 
GCCAGCCCGC GCCTGAGCCC CAGCCCGCTG CCCGTCGCAC TGGGCTCCGG GCCGGGACCT 
GGGCCGGGGC CACAGCCGCT CAAGGGCGCA CTGTGGGCCG GTGTGGCGGG CGGTGGGGGC 
GGCGGGCCTG GCGCGGGAGC GGCCGAACTA CTTAAGGCTT GGCAGCCGGC GGAGTCCGGC 
CCCGGGCCCT TCTCCGGGGT TCTGTCCTCC TTTCACCGGA AGCCCGGCCC CGCCCTGAAG 
ACCAATCTCT TCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005160.2
CDS	173..1027
Translation	MDYSYLNSYDSCVAAMEASAYGDFGACSQPGGFQYSPLRPAFPAAGPPCPALGSSNCALGALRDHQPAPYSAVPYKFFPEPSGLHEKRKQRRIRTTFTSAQLKELERVFAETHYPDIYTREELALKIDLTEARVQVWFQNRRAKFRKQERAASAKGAAGAAGAKKGEARCSSEDDDSKESTCSPTPDSTASLPPPPAPGLASPRLSPSPLPVALGSGPGPGPGPQPLKGALWAGVAGGGGGGPGAGAAELLKAWQPAESGPGPFSGVLSSFHRKPGPALKTNLF

Target ORF information:

RefSeq Version	NM_005169.4
Organism	Homo sapiens(human)
Definition	Homo sapiens paired like homeobox 2A (PHOX2A), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005169.4

ORF Insert Sequence:

ATGGACTACT CCTACCTCAA TTCGTACGAC TCGTGCGTGG CGGCCATGGA GGCGTCCGCC 
TACGGCGACT TTGGCGCCTG CAGCCAGCCC GGCGGCTTCC AATACAGCCC CCTGCGGCCC 
GCTTTCCCCG CGGCAGGGCC GCCCTGCCCC GCGCTCGGCT CCTCCAACTG CGCACTTGGC 
GCCCTACGCG ACCACCAGCC CGCGCCCTAC TCGGCAGTGC CCTACAAGTT CTTCCCAGAG 
CCATCCGGCC TGCACGAGAA GCGCAAGCAG CGGCGCATCC GCACCACGTT CACCAGCGCG 
CAGCTCAAGG AGCTGGAGCG CGTTTTCGCT GAGACCCACT ACCCCGACAT TTACACGCGT 
GAGGAGCTGG CGCTCAAGAT CGACCTCACT GAGGCTCGCG TGCAGGTCTG GTTCCAGAAC 
CGCCGGGCCA AGTTCCGCAA ACAGGAGCGC GCGGCCAGCG CCAAGGGCGC GGCGGGCGCG 
GCGGGCGCCA AAAAGGGCGA GGCGCGCTGC TCCTCCGAGG ACGACGATTC CAAGGAGTCC 
ACGTGCAGCC CCACGCCCGA TAGCACCGCC TCGCTGCCGC CGCCGCCTGC GCCCGGCCTG 
GCCAGCCCGC GCCTGAGCCC CAGCCCGCTG CCCGTCGCAC TGGGCTCCGG GCCGGGACCT 
GGGCCGGGGC CACAGCCGCT CAAGGGCGCA CTGTGGGCCG GTGTGGCGGG CGGTGGGGGC 
GGCGGGCCTG GCGCGGGAGC GGCCGAACTA CTTAAGGCTT GGCAGCCGGC GGAGTCCGGC 
CCCGGGCCCT TCTCCGGGGT TCTGTCCTCC TTTCACCGGA AGCCCGGCCC CGCCCTGAAG 
ACCAATCTCT TCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PHOX2A ( NM_005169.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_005160.2 Homo sapiens paired like homeobox 2a (PHOX2A), mRNA.

Price & Availability↑

CloneID	OHu18020
Clone ID Related Accession (Same CDS sequence)	NM_005169.4 , NM_005169.3
Accession Version	NM_005169.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 855bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	paired mesoderm homeobox protein 2A
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK290645.1 and BC041564.1. This sequence is a reference standard in the RefSeqGene project. On May 20, 2008 this sequence version replaced NM_005169.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC041564.1, BX376662.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1968968 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGACTACT CCTACCTCAA TTCGTACGAC TCGTGCGTGG CGGCCATGGA GGCGTCCGCC 
TACGGCGACT TTGGCGCCTG CAGCCAGCCC GGCGGCTTCC AATACAGCCC CCTGCGGCCC 
GCTTTCCCCG CGGCAGGGCC GCCCTGCCCC GCGCTCGGCT CCTCCAACTG CGCACTTGGC 
GCCCTACGCG ACCACCAGCC CGCGCCCTAC TCGGCAGTGC CCTACAAGTT CTTCCCAGAG 
CCATCCGGCC TGCACGAGAA GCGCAAGCAG CGGCGCATCC GCACCACGTT CACCAGCGCG 
CAGCTCAAGG AGCTGGAGCG CGTTTTCGCT GAGACCCACT ACCCCGACAT TTACACGCGT 
GAGGAGCTGG CGCTCAAGAT CGACCTCACT GAGGCTCGCG TGCAGGTCTG GTTCCAGAAC 
CGCCGGGCCA AGTTCCGCAA ACAGGAGCGC GCGGCCAGCG CCAAGGGCGC GGCGGGCGCG 
GCGGGCGCCA AAAAGGGCGA GGCGCGCTGC TCCTCCGAGG ACGACGATTC CAAGGAGTCC 
ACGTGCAGCC CCACGCCCGA TAGCACCGCC TCGCTGCCGC CGCCGCCTGC GCCCGGCCTG 
GCCAGCCCGC GCCTGAGCCC CAGCCCGCTG CCCGTCGCAC TGGGCTCCGG GCCGGGACCT 
GGGCCGGGGC CACAGCCGCT CAAGGGCGCA CTGTGGGCCG GTGTGGCGGG CGGTGGGGGC 
GGCGGGCCTG GCGCGGGAGC GGCCGAACTA CTTAAGGCTT GGCAGCCGGC GGAGTCCGGC 
CCCGGGCCCT TCTCCGGGGT TCTGTCCTCC TTTCACCGGA AGCCCGGCCC CGCCCTGAAG 
ACCAATCTCT TCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005160.2
CDS	173..1027
Translation	MDYSYLNSYDSCVAAMEASAYGDFGACSQPGGFQYSPLRPAFPAAGPPCPALGSSNCALGALRDHQPAPYSAVPYKFFPEPSGLHEKRKQRRIRTTFTSAQLKELERVFAETHYPDIYTREELALKIDLTEARVQVWFQNRRAKFRKQERAASAKGAAGAAGAKKGEARCSSEDDDSKESTCSPTPDSTASLPPPPAPGLASPRLSPSPLPVALGSGPGPGPGPQPLKGALWAGVAGGGGGGPGAGAAELLKAWQPAESGPGPFSGVLSSFHRKPGPALKTNLF

Target ORF information:

RefSeq Version	NM_005169.3
Organism	Homo sapiens(human)
Definition	Homo sapiens paired like homeobox 2a (PHOX2A), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005169.3

ORF Insert Sequence:

ATGGACTACT CCTACCTCAA TTCGTACGAC TCGTGCGTGG CGGCCATGGA GGCGTCCGCC 
TACGGCGACT TTGGCGCCTG CAGCCAGCCC GGCGGCTTCC AATACAGCCC CCTGCGGCCC 
GCTTTCCCCG CGGCAGGGCC GCCCTGCCCC GCGCTCGGCT CCTCCAACTG CGCACTTGGC 
GCCCTACGCG ACCACCAGCC CGCGCCCTAC TCGGCAGTGC CCTACAAGTT CTTCCCAGAG 
CCATCCGGCC TGCACGAGAA GCGCAAGCAG CGGCGCATCC GCACCACGTT CACCAGCGCG 
CAGCTCAAGG AGCTGGAGCG CGTTTTCGCT GAGACCCACT ACCCCGACAT TTACACGCGT 
GAGGAGCTGG CGCTCAAGAT CGACCTCACT GAGGCTCGCG TGCAGGTCTG GTTCCAGAAC 
CGCCGGGCCA AGTTCCGCAA ACAGGAGCGC GCGGCCAGCG CCAAGGGCGC GGCGGGCGCG 
GCGGGCGCCA AAAAGGGCGA GGCGCGCTGC TCCTCCGAGG ACGACGATTC CAAGGAGTCC 
ACGTGCAGCC CCACGCCCGA TAGCACCGCC TCGCTGCCGC CGCCGCCTGC GCCCGGCCTG 
GCCAGCCCGC GCCTGAGCCC CAGCCCGCTG CCCGTCGCAC TGGGCTCCGG GCCGGGACCT 
GGGCCGGGGC CACAGCCGCT CAAGGGCGCA CTGTGGGCCG GTGTGGCGGG CGGTGGGGGC 
GGCGGGCCTG GCGCGGGAGC GGCCGAACTA CTTAAGGCTT GGCAGCCGGC GGAGTCCGGC 
CCCGGGCCCT TCTCCGGGGT TCTGTCCTCC TTTCACCGGA AGCCCGGCCC CGCCCTGAAG 
ACCAATCTCT TCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

PHOX2A and PHOX2B are differentially regulated during retinoic acid-driven differentiation of SK-N-BE(2)C neuroblastoma cell line.
Experimental cell research342(1)62-71(2016 Mar)
Di Lascio S,Saba E,Belperio D,Raimondi A,Lucchetti H,Fornasari D,Benfante R

Phenotype-phenotype and genotype-phenotype correlations in patients with idiopathic superior oblique muscle palsy.
Journal of human genetics57(2)122-9(2012 Feb)
Ohkubo SI,Matsuo T,Hasebe K,Shira YH,Itoshima E,Ohtsuki H

[Identification of a novel PHOX2A gene mutation in a Chinese family with congenital fibrosis of extraocular muscles type 2].
Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics29(1)5-8(2012 Feb)
Dong JM,Shen Q,Li J,Du W,Pang HL,Lin SF,Bu J

Mutations in KIF21A and PHOX2A are absent in 16 patients with congenital vertical incomitant strabismus.
Ophthalmic genetics30(4)206-7(2009 Dec)
Khan AO,Khalil DS,Al-Sharif LJ,Al-Tassan NA

- Most Popular Services
  - 人工遺伝子合成& DNA合成-納期保証
- Services & Products

見積依頼

Eメール

japanmarket@genscript.com

電話

03-6811-6572

FAX

03-6811-6573
050-3174-7589(受注専用)

オンラインフォーム

オンライン注文

PHOX2A cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Most Popular Services

Services & Products

見積依頼

Eメール

電話

FAX

オンラインフォーム

サポート

会社情報

サポート

会社情報