MED11 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	MED11
Entrez Gene ID	400569
Full Name	mediator complex subunit 11
Synonyms	HSPC296
General protein information	Preferred Names mediator complex subunit 11 Names mediator of RNA polymerase II transcription subunit 11 mediator of RNA polymerase II transcription, subunit 11 homolog
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 17 Map Location: 17p13.2
Summary	MED11 is a component of the Mediator complex, which is a coactivator for DNA-binding factors that activate transcription via RNA polymerase II (Sato et al., 2003 [PubMed 12584197]).[supplied by OMIM, Oct 2008].
Disorder MIM:	612383

mRNA and Protein(s)

mRNA	Protein	Name
NM_001001683.3	NP_001001683.1	mediator of RNA polymerase II transcription subunit 11 isoform a
NM_001001683.4	NP_001001683.1	mediator of RNA polymerase II transcription subunit 11 isoform a
NM_001305000.2	NP_001291929.1	mediator of RNA polymerase II transcription subunit 11 isoform b
NM_001305000.1	NP_001291929.1	mediator of RNA polymerase II transcription subunit 11 isoform b

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	MED11	XP_849319.2
Bos taurus (cattle)	MED11	NP_001033173.1
Danio rerio (zebrafish)	LOC100534983	XP_003199394.1
	MED11	XP_001095324.1
Drosophila melanogaster (fruit fly)	MED11	NP_649057.1
Homo sapiens (human)	MED11	NP_001001683.1
Rattus norvegicus (Norway rat)	Med11	NP_001099269.1
Danio rerio (zebrafish)	med11	NP_001153507.1
Mus musculus (house mouse)	Med11	NP_079673.2
Pan troglodytes (chimpanzee)	MED11	XP_001161315.1
Xenopus tropicalis (tropical clawed frog)	med11	NP_989379.1

Gene Ontology
Bibliography

Related articles in PubMed

A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology.
Sato S, Tomomori-Sato C, Parmely TJ, Florens L, Zybailov B, Swanson SK, Banks CA, Jin J, Cai Y, Washburn MP, Conaway JW, Conaway RC
Molecular cell14(5)685-91(2004 Jun)

A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2.
Tomomori-Sato C, Sato S, Parmely TJ, Banks CA, Sorokina I, Florens L, Zybailov B, Washburn MP, Brower CS, Conaway RC, Conaway JW
The Journal of biological chemistry279(7)5846-51(2004 Feb)

Identification of mammalian Mediator subunits with similarities to yeast Mediator subunits Srb5, Srb6, Med11, and Rox3.
Sato S, Tomomori-Sato C, Banks CA, Sorokina I, Parmely TJ, Kong SE, Jin J, Cai Y, Lane WS, Brower CS, Conaway RC, Conaway JW
The Journal of biological chemistry278(17)15123-7(2003 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following MED11 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MED11 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu31309	NM_001001683.4 Latest version!	Homo sapiens mediator complex subunit 11 (MED11), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu80113	NM_001305000.2 Latest version!	Homo sapiens mediator complex subunit 11 (MED11), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
View Old Accession Versions >>
OHu31309	NM_001001683.3	Homo sapiens mediator complex subunit 11 (MED11), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu80113	NM_001305000.1	Homo sapiens mediator complex subunit 11 (MED11), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

MED11 ( NM_001001683.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001001683.1 Homo sapiens mediator complex subunit 11 (MED11), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu31309
Clone ID Related Accession (Same CDS sequence)	NM_001001683.3 , NM_001001683.4
Accession Version	NM_001001683.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 354bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-02
Organism	Homo sapiens(human)
Product	mediator of RNA polymerase II transcription subunit 11 isoform a
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from HY036468.1, BC070377.1 and AA806707.1. On Feb 13, 2015 this sequence version replaced NM_001001683.2. Transcript Variant: This variant (1) encodes the longer isoform (a). ##Evidence-Data-START## Transcript exon combination :: CR983796.1, SRR1163655.331974.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCTACCT ACAGCCTGGC GAACGAGAGA CTACGCGCTC TGGAAGACAT TGAACGGGAA 
ATCGGCGCCA TCCTTCAGAA TGCAGGTACT GTGATCCTAG AATTGTCCAA GGAAAAAACT 
AACGAGCGGC TCCTAGACCG GCAGGCGGCG GCCTTCACCG CTTCAGTGCA ACACGTGGAG 
GCGGAGCTGT CAGCTCAGAT CCGCTACCTC ACCCAGGTGG CCACAGGGCA GCCCCATGAG 
GGCTCCAGCT ACTCTTCGAG GAAGGACTGT CAGATGGCTC TGAAGCGAGT GGACTATGCC 
CGCCTCAAGC TCAGTGATGT GGCTCGAACC TGTGAGCAGA TGCTGGAGAA CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001001683.1
CDS	83..436
Translation	MATYSLANERLRALEDIEREIGAILQNAGTVILELSKEKTNERLLDRQAAAFTASVQHVEAELSAQIRYLTQVATGQPHEGSSYSSRKDCQMALKRVDYARLKLSDVARTCEQMLEN

Target ORF information:

RefSeq Version	NM_001001683.3
Organism	Homo sapiens(human)
Definition	Homo sapiens mediator complex subunit 11 (MED11), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001001683.3

ORF Insert Sequence:

ATGGCTACCT ACAGCCTGGC GAACGAGAGA CTACGCGCTC TGGAAGACAT TGAACGGGAA 
ATCGGCGCCA TCCTTCAGAA TGCAGGTACT GTGATCCTAG AATTGTCCAA GGAAAAAACT 
AACGAGCGGC TCCTAGACCG GCAGGCGGCG GCCTTCACCG CTTCAGTGCA ACACGTGGAG 
GCGGAGCTGT CAGCTCAGAT CCGCTACCTC ACCCAGGTGG CCACAGGGCA GCCCCATGAG 
GGCTCCAGCT ACTCTTCGAG GAAGGACTGT CAGATGGCTC TGAAGCGAGT GGACTATGCC 
CGCCTCAAGC TCAGTGATGT GGCTCGAACC TGTGAGCAGA TGCTGGAGAA CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MED11 ( NM_001001683.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_001001683.1 Homo sapiens mediator complex subunit 11 (MED11), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu31309
Clone ID Related Accession (Same CDS sequence)	NM_001001683.3 , NM_001001683.4
Accession Version	NM_001001683.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 354bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-01
Organism	Homo sapiens(human)
Product	mediator of RNA polymerase II transcription subunit 11 isoform a
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC091153.10. On Nov 22, 2018 this sequence version replaced NM_001001683.3. Transcript Variant: This variant (1) encodes the longer isoform (a). ##Evidence-Data-START## Transcript exon combination :: BC070377.1, SRR1803616.146311.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000293777.6/ ENSP00000293777.5 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCTACCT ACAGCCTGGC GAACGAGAGA CTACGCGCTC TGGAAGACAT TGAACGGGAA 
ATCGGCGCCA TCCTTCAGAA TGCAGGTACT GTGATCCTAG AATTGTCCAA GGAAAAAACT 
AACGAGCGGC TCCTAGACCG GCAGGCGGCG GCCTTCACCG CTTCAGTGCA ACACGTGGAG 
GCGGAGCTGT CAGCTCAGAT CCGCTACCTC ACCCAGGTGG CCACAGGGCA GCCCCATGAG 
GGCTCCAGCT ACTCTTCGAG GAAGGACTGT CAGATGGCTC TGAAGCGAGT GGACTATGCC 
CGCCTCAAGC TCAGTGATGT GGCTCGAACC TGTGAGCAGA TGCTGGAGAA CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001001683.1
CDS	63..416
Translation	MATYSLANERLRALEDIEREIGAILQNAGTVILELSKEKTNERLLDRQAAAFTASVQHVEAELSAQIRYLTQVATGQPHEGSSYSSRKDCQMALKRVDYARLKLSDVARTCEQMLEN

Target ORF information:

RefSeq Version	NM_001001683.4
Organism	Homo sapiens(human)
Definition	Homo sapiens mediator complex subunit 11 (MED11), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001001683.4

ORF Insert Sequence:

ATGGCTACCT ACAGCCTGGC GAACGAGAGA CTACGCGCTC TGGAAGACAT TGAACGGGAA 
ATCGGCGCCA TCCTTCAGAA TGCAGGTACT GTGATCCTAG AATTGTCCAA GGAAAAAACT 
AACGAGCGGC TCCTAGACCG GCAGGCGGCG GCCTTCACCG CTTCAGTGCA ACACGTGGAG 
GCGGAGCTGT CAGCTCAGAT CCGCTACCTC ACCCAGGTGG CCACAGGGCA GCCCCATGAG 
GGCTCCAGCT ACTCTTCGAG GAAGGACTGT CAGATGGCTC TGAAGCGAGT GGACTATGCC 
CGCCTCAAGC TCAGTGATGT GGCTCGAACC TGTGAGCAGA TGCTGGAGAA CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MED11 ( NM_001305000.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001291929.1 Homo sapiens mediator complex subunit 11 (MED11), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu80113
Clone ID Related Accession (Same CDS sequence)	NM_001305000.2 , NM_001305000.1
Accession Version	NM_001305000.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 258bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-30
Organism	Homo sapiens(human)
Product	mediator of RNA polymerase II transcription subunit 11 isoform b
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC091153.10. On May 31, 2019 this sequence version replaced NM_001305000.1. Transcript Variant: This variant (2) uses an alternate splice site in the 3' terminal exon, resulting in an alternate 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (b) has a distinct C-terminus and is shorter than isoform a. ##Evidence-Data-START## Transcript exon combination :: BG503911.1, SRR1163657.309011.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCTACCT ACAGCCTGGC GAACGAGAGA CTACGCGCTC TGGAAGACAT TGAACGGGAA 
ATCGGCGCCA TCCTTCAGAA TGCAGGTACT GTGATCCTAG AATTGTCCAA GGAAAAAACT 
AACGAGCGGC TCCTAGACCG GCAGGCGGCG GCCTTCACCG CTTCAGTGCA ACACGTGGAG 
GCGGAGCTGT CAGCTCAGAT CCGCTACCTC ACCCAGCTAC CAGATGGCCT AACAAATTCA 
AACTCAGGGA AGAAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001291929.1
CDS	63..320
Translation	MATYSLANERLRALEDIEREIGAILQNAGTVILELSKEKTNERLLDRQAAAFTASVQHVEAELSAQIRYLTQLPDGLTNSNSGKK

Target ORF information:

RefSeq Version	NM_001305000.2
Organism	Homo sapiens(human)
Definition	Homo sapiens mediator complex subunit 11 (MED11), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001305000.2

ORF Insert Sequence:

ATGGCTACCT ACAGCCTGGC GAACGAGAGA CTACGCGCTC TGGAAGACAT TGAACGGGAA 
ATCGGCGCCA TCCTTCAGAA TGCAGGTACT GTGATCCTAG AATTGTCCAA GGAAAAAACT 
AACGAGCGGC TCCTAGACCG GCAGGCGGCG GCCTTCACCG CTTCAGTGCA ACACGTGGAG 
GCGGAGCTGT CAGCTCAGAT CCGCTACCTC ACCCAGCTAC CAGATGGCCT AACAAATTCA 
AACTCAGGGA AGAAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MED11 ( NM_001305000.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001291929.1 Homo sapiens mediator complex subunit 11 (MED11), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu80113
Clone ID Related Accession (Same CDS sequence)	NM_001305000.2 , NM_001305000.1
Accession Version	NM_001305000.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 258bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-06-30
Organism	Homo sapiens(human)
Product	mediator of RNA polymerase II transcription subunit 11 isoform b
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from HY036468.1, BG503911.1, BC070377.1 and AA806707.1. Transcript Variant: This variant (2) uses an alternate splice site in the 3' terminal exon, resulting in an alternate 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (b) has a distinct C-terminus and is shorter than isoform a. ##Evidence-Data-START## Transcript exon combination :: SRR1163657.309011.1, BG503911.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCTACCT ACAGCCTGGC GAACGAGAGA CTACGCGCTC TGGAAGACAT TGAACGGGAA 
ATCGGCGCCA TCCTTCAGAA TGCAGGTACT GTGATCCTAG AATTGTCCAA GGAAAAAACT 
AACGAGCGGC TCCTAGACCG GCAGGCGGCG GCCTTCACCG CTTCAGTGCA ACACGTGGAG 
GCGGAGCTGT CAGCTCAGAT CCGCTACCTC ACCCAGCTAC CAGATGGCCT AACAAATTCA 
AACTCAGGGA AGAAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001291929.1
CDS	83..340
Translation	MATYSLANERLRALEDIEREIGAILQNAGTVILELSKEKTNERLLDRQAAAFTASVQHVEAELSAQIRYLTQLPDGLTNSNSGKK

Target ORF information:

RefSeq Version	NM_001305000.1
Organism	Homo sapiens(human)
Definition	Homo sapiens mediator complex subunit 11 (MED11), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001305000.1

ORF Insert Sequence:

ATGGCTACCT ACAGCCTGGC GAACGAGAGA CTACGCGCTC TGGAAGACAT TGAACGGGAA 
ATCGGCGCCA TCCTTCAGAA TGCAGGTACT GTGATCCTAG AATTGTCCAA GGAAAAAACT 
AACGAGCGGC TCCTAGACCG GCAGGCGGCG GCCTTCACCG CTTCAGTGCA ACACGTGGAG 
GCGGAGCTGT CAGCTCAGAT CCGCTACCTC ACCCAGCTAC CAGATGGCCT AACAAATTCA 
AACTCAGGGA AGAAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology.
Molecular cell14(5)685-91(2004 Jun)
Sato S,Tomomori-Sato C,Parmely TJ,Florens L,Zybailov B,Swanson SK,Banks CA,Jin J,Cai Y,Washburn MP,Conaway JW,Conaway RC

A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2.
The Journal of biological chemistry279(7)5846-51(2004 Feb)
Tomomori-Sato C,Sato S,Parmely TJ,Banks CA,Sorokina I,Florens L,Zybailov B,Washburn MP,Brower CS,Conaway RC,Conaway JW

Identification of mammalian Mediator subunits with similarities to yeast Mediator subunits Srb5, Srb6, Med11, and Rox3.
The Journal of biological chemistry278(17)15123-7(2003 Apr)
Sato S,Tomomori-Sato C,Banks CA,Sorokina I,Parmely TJ,Kong SE,Jin J,Cai Y,Lane WS,Brower CS,Conaway RC,Conaway JW

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MED11 cDNA ORF clone, Homo sapiens(human)

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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