C15orf53 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	C15orf53
Entrez Gene ID	400359
Full Name	chromosome 15 open reading frame 53
General protein information	Preferred Names chromosome 15 open reading frame 53 Names uncharacterized protein C15orf53
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 15 Map Location: 15q14

mRNA and Protein(s)

mRNA	Protein	Name
NM_207444.2	NP_997327.1	uncharacterized protein C15orf53

Pathways from BioSystems

Homologies

Homo sapiens (human)	C15orf53	NP_997327.1
Pan troglodytes (chimpanzee)	C15H15orf53	XP_003314650.1

Gene Ontology
Bibliography

Related articles in PubMed

A genome-wide association study of alcohol-dependence symptom counts in extended pedigrees identifies C15orf53.
Wang JC, Foroud T, Hinrichs AL, Le NX, Bertelsen S, Budde JP, Harari O, Koller DL, Wetherill L, Agrawal A, Almasy L, Brooks AI, Bucholz K, Dick D, Hesselbrock V, Johnson EO, Kang S, Kapoor M, Kramer J, Kuperman S, Madden PA, Manz N, Martin NG, McClintick JN, Montgomery GW, Nurnberger JI Jr, Rangaswamy M, Rice J, Schuckit M, Tischfield JA, Whitfield JB, Xuei X, Porjesz B, Heath AC, Edenberg HJ, Bierut LJ, Goate AM
Molecular psychiatry18(11)1218-24(2013 Nov)

Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4.

Nature genetics43(10)977-83(2011 Sep)

Meta-analysis of genome-wide association data of bipolar disorder and major depressive disorder.
Liu Y, Blackwood DH, Caesar S, de Geus EJ, Farmer A, Ferreira MA, Ferrier IN, Fraser C, Gordon-Smith K, Green EK, Grozeva D, Gurling HM, Hamshere ML, Heutink P, Holmans PA, Hoogendijk WJ, Hottenga JJ, Jones L, Jones IR, Kirov G, Lin D, McGuffin P, Moskvina V, Nolen WA, Perlis RH, Posthuma D, Scolnick EM, Smit AB, Smit JH, Smoller JW, St Clair D, van Dyck R, Verhage M, Willemsen G, Young AH, Zandbelt T, Boomsma DI, Craddock N, O'Donovan MC, Owen MJ, Penninx BW, Purcell S, Sklar P, Sullivan PF,
Molecular psychiatry16(1)2-4(2011 Jan)

Genome-wide association study of bipolar disorder in European American and African American individuals.
Smith EN, Bloss CS, Badner JA, Barrett T, Belmonte PL, Berrettini W, Byerley W, Coryell W, Craig D, Edenberg HJ, Eskin E, Foroud T, Gershon E, Greenwood TA, Hipolito M, Koller DL, Lawson WB, Liu C, Lohoff F, McInnis MG, McMahon FJ, Mirel DB, Murray SS, Nievergelt C, Nurnberger J, Nwulia EA, Paschall J, Potash JB, Rice J, Schulze TG, Scheftner W, Panganiban C, Zaitlen N, Zandi PP, Z?llner S, Schork NJ, Kelsoe JR
Molecular psychiatry14(8)755-63(2009 Aug)

Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder.
Ferreira MA, O'Donovan MC, Meng YA, Jones IR, Ruderfer DM, Jones L, Fan J, Kirov G, Perlis RH, Green EK, Smoller JW, Grozeva D, Stone J, Nikolov I, Chambert K, Hamshere ML, Nimgaonkar VL, Moskvina V, Thase ME, Caesar S, Sachs GS, Franklin J, Gordon-Smith K, Ardlie KG, Gabriel SB, Fraser C, Blumenstiel B, Defelice M, Breen G, Gill M, Morris DW, Elkin A, Muir WJ, McGhee KA, Williamson R, MacIntyre DJ, MacLean AW, St CD, Robinson M, Van Beck M, Pereira AC, Kandaswamy R, McQuillin A, Collier DA, Bass NJ, Young AH, Lawrence J, Ferrier IN, Anjorin A, Farmer A, Curtis D, Scolnick EM, McGuffin P, Daly MJ, Corvin AP, Holmans PA, Blackwood DH, Gurling HM, Owen MJ, Purcell SM, Sklar P, Craddock N,
Nature genetics40(9)1056-8(2008 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

This family-based GWAS identified SNPs in C15orf53 that are strongly associated with DSM-IV alcohol-dependence symptoms.
Title: A genome-wide association study of alcohol-dependence symptom counts in extended pedigrees identifies C15orf53.

Meta-analysis and genome-wide association study of gene-disease association. (HuGE Navigator)
Title: Meta-analysis of genome-wide association data of bipolar disorder and major depressive disorder.

Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
Title: Genome-wide association study of bipolar disorder in European American and African American individuals.

The following C15orf53 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the C15orf53 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu31471	NM_207444.2 Latest version!	Homo sapiens chromosome 15 open reading frame 53 (C15orf53), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

C15orf53 ( NM_207444.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_997327.1 Homo sapiens chromosome 15 open reading frame 53 (C15orf53), mRNA.

Price & Availability↑

CloneID	OHu31471
Clone ID Related Accession (Same CDS sequence)	NM_207444.2
Accession Version	NM_207444.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 540bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-06-22
Organism	Homo sapiens(human)
Product	uncharacterized protein C15orf53
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK093014.1 and AC104261.4. On Nov 22, 2008 this sequence version replaced NM_207444.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. ##Evidence-Data-START## Transcript exon combination :: AK093014.1, BC119810.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968189, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGCTAC AAGGGGCCCA AGAGGACCTG GGCATTTCCC TCTCTAGTCC CCGGAGGAAC 
CATGAAACCA GGCCAGGAAG CAAGGCTAAG GGCAGGAGCA GCATCTGTCT CCAGGCGTCT 
GTTTGGATGG CTGGAGGAAA GCTGAGGCTC AGAGCAAGTG AACATCTAAC CCAGGGCCAC 
CAACAAGAGC TCAGGGATTG GAATCTGGGA GAAGATGCTT CCCTTCTCTT CTCCAAGAGT 
CCTTTTGGGG CTGGCAAGTT GATACAAGCT CCAGCTCATG TCTTCAGACA ATGCTGGGTC 
CAAGGAAATG CATGGATCTC CTGCATTACA AAGTTTGACT CCAAGAGAAG CCCAGAAGTG 
GCTTCCAGCC CCTCCTACCT AACTGTGCCC CGCCGTTCAC CACTTCCTGT CTTCCTGCGA 
CCCAGTGACA GATGTGTCTG TGGGGGCTGC TACTTGGGAA AGTCCACCAG GAGGAGAGCA 
TGCCAATCTC TCCTCTCAGA TCCTCTGGGG GTTACTTTCC CCACCCAAAC TAGGCCTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_997327.1
CDS	11..550
Translation	MELQGAQEDLGISLSSPRRNHETRPGSKAKGRSSICLQASVWMAGGKLRLRASEHLTQGHQQELRDWNLGEDASLLFSKSPFGAGKLIQAPAHVFRQCWVQGNAWISCITKFDSKRSPEVASSPSYLTVPRRSPLPVFLRPSDRCVCGGCYLGKSTRRRACQSLLSDPLGVTFPTQTRP

Target ORF information:

RefSeq Version	NM_207444.2
Organism	Homo sapiens(human)
Definition	Homo sapiens chromosome 15 open reading frame 53 (C15orf53), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_207444.2

ORF Insert Sequence:

ATGGAGCTAC AAGGGGCCCA AGAGGACCTG GGCATTTCCC TCTCTAGTCC CCGGAGGAAC 
CATGAAACCA GGCCAGGAAG CAAGGCTAAG GGCAGGAGCA GCATCTGTCT CCAGGCGTCT 
GTTTGGATGG CTGGAGGAAA GCTGAGGCTC AGAGCAAGTG AACATCTAAC CCAGGGCCAC 
CAACAAGAGC TCAGGGATTG GAATCTGGGA GAAGATGCTT CCCTTCTCTT CTCCAAGAGT 
CCTTTTGGGG CTGGCAAGTT GATACAAGCT CCAGCTCATG TCTTCAGACA ATGCTGGGTC 
CAAGGAAATG CATGGATCTC CTGCATTACA AAGTTTGACT CCAAGAGAAG CCCAGAAGTG 
GCTTCCAGCC CCTCCTACCT AACTGTGCCC CGCCGTTCAC CACTTCCTGT CTTCCTGCGA 
CCCAGTGACA GATGTGTCTG TGGGGGCTGC TACTTGGGAA AGTCCACCAG GAGGAGAGCA 
TGCCAATCTC TCCTCTCAGA TCCTCTGGGG GTTACTTTCC CCACCCAAAC TAGGCCTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A genome-wide association study of alcohol-dependence symptom counts in extended pedigrees identifies C15orf53.
Molecular psychiatry18(11)1218-24(2013 Nov)
Wang JC,Foroud T,Hinrichs AL,Le NX,Bertelsen S,Budde JP,Harari O,Koller DL,Wetherill L,Agrawal A,Almasy L,Brooks AI,Bucholz K,Dick D,Hesselbrock V,Johnson EO,Kang S,Kapoor M,Kramer J,Kuperman S,Madden PA,Manz N,Martin NG,McClintick JN,Montgomery GW,Nurnberger JI Jr,Rangaswamy M,Rice J,Schuckit M,Tischfield JA,Whitfield JB,Xuei X,Porjesz B,Heath AC,Edenberg HJ,Bierut LJ,Goate AM

Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4.
Nature genetics43(10)977-83(2011 Sep)

Meta-analysis of genome-wide association data of bipolar disorder and major depressive disorder.
Molecular psychiatry16(1)2-4(2011 Jan)
Liu Y,Blackwood DH,Caesar S,de Geus EJ,Farmer A,Ferreira MA,Ferrier IN,Fraser C,Gordon-Smith K,Green EK,Grozeva D,Gurling HM,Hamshere ML,Heutink P,Holmans PA,Hoogendijk WJ,Hottenga JJ,Jones L,Jones IR,Kirov G,Lin D,McGuffin P,Moskvina V,Nolen WA,Perlis RH,Posthuma D,Scolnick EM,Smit AB,Smit JH,Smoller JW,St Clair D,van Dyck R,Verhage M,Willemsen G,Young AH,Zandbelt T,Boomsma DI,Craddock N,O'Donovan MC,Owen MJ,Penninx BW,Purcell S,Sklar P,Sullivan PF,

Genome-wide association study of bipolar disorder in European American and African American individuals.
Molecular psychiatry14(8)755-63(2009 Aug)
Smith EN,Bloss CS,Badner JA,Barrett T,Belmonte PL,Berrettini W,Byerley W,Coryell W,Craig D,Edenberg HJ,Eskin E,Foroud T,Gershon E,Greenwood TA,Hipolito M,Koller DL,Lawson WB,Liu C,Lohoff F,McInnis MG,McMahon FJ,Mirel DB,Murray SS,Nievergelt C,Nurnberger J,Nwulia EA,Paschall J,Potash JB,Rice J,Schulze TG,Scheftner W,Panganiban C,Zaitlen N,Zandi PP,Z?llner S,Schork NJ,Kelsoe JR

Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder.
Nature genetics40(9)1056-8(2008 Sep)
Ferreira MA,O'Donovan MC,Meng YA,Jones IR,Ruderfer DM,Jones L,Fan J,Kirov G,Perlis RH,Green EK,Smoller JW,Grozeva D,Stone J,Nikolov I,Chambert K,Hamshere ML,Nimgaonkar VL,Moskvina V,Thase ME,Caesar S,Sachs GS,Franklin J,Gordon-Smith K,Ardlie KG,Gabriel SB,Fraser C,Blumenstiel B,Defelice M,Breen G,Gill M,Morris DW,Elkin A,Muir WJ,McGhee KA,Williamson R,MacIntyre DJ,MacLean AW,St CD,Robinson M,Van Beck M,Pereira AC,Kandaswamy R,McQuillin A,Collier DA,Bass NJ,Young AH,Lawrence J,Ferrier IN,Anjorin A,Farmer A,Curtis D,Scolnick EM,McGuffin P,Daly MJ,Corvin AP,Holmans PA,Blackwood DH,Gurling HM,Owen MJ,Purcell SM,Sklar P,Craddock N,

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C15orf53 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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