LMAN1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	LMAN1
Entrez Gene ID	3998
Full Name	lectin, mannose binding 1
Synonyms	ERGIC-53,ERGIC53,F5F8D,FMFD1,MCFD1,MR60,gp58
General protein information	Preferred Names lectin, mannose binding 1 Names protein ERGIC-53 ER-Golgi intermediate compartment 53 kDa protein endoplasmic reticulum-golgi intermediate compartment protein 53 intracellular mannose-specific lectin MR60
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 18 Map Location: 18q21.32
Summary	The protein encoded by this gene is a membrane mannose-specific lectin that cycles between the endoplasmic reticulum, endoplasmic reticulum-Golgi intermediate compartment, and cis-Golgi, functioning as a cargo receptor for glycoprotein transport. The protein has an N-terminal signal sequence, a calcium-dependent and pH-sensitive carbohydrate recognition domain, a stalk region that functions in oligomerization, a transmembrane domain, and a short cytoplasmic domain required for organelle targeting. Allelic variants of this gene are associated with the autosomal recessive disorder combined factor V-factor VIII deficiency. [provided by RefSeq, Jul 2015].
Disorder MIM:	601567
Disorder Html:	Combined factor V and VIII deficiency, 227300 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_005570.3	NP_005561.1	protein ERGIC-53 precursor
NM_005570.4	NP_005561.1	protein ERGIC-53 precursor

Pathways from BioSystems

Homologies

	LMAN1	XP_001088053.1
Bos taurus (cattle)	LMAN1	NP_001092413.1
Mus musculus (house mouse)	Lman1	NP_001165533.1
Gallus gallus (chicken)	LMAN1	NP_001026570.1
Pan troglodytes (chimpanzee)	LMAN1	XP_001143039.1
Rattus norvegicus (Norway rat)	Lman1	NP_446338.1
Homo sapiens (human)	LMAN1	NP_005561.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP005404	XP_315413.3
Caenorhabditis elegans (roundworm)	ile-1	NP_492548.1
Canis lupus familiaris (dog)	LMAN1	XP_533390.2
Danio rerio (zebrafish)	lman1	XP_688661.4
Xenopus tropicalis (tropical clawed frog)	lman1	NP_001234922.1
Drosophila melanogaster (fruit fly)	ergic53	NP_524776.1

Gene Ontology
Bibliography

Related articles in PubMed

Combined deficiency of factors V and VIII by chance coinheritance of parahaemophilia and haemophilia A, but not by mutations of either LMAN1 or MCFD2, in a Japanese family.
Suzuki S, Nakamura Y, Suzuki N, Yamazaki T, Takagi Y, Tamura S, Takagi A, Kanematsu T, Matsushita T, Kojima T
Haemophilia : the official journal of the World Federation of Hemophilia24(1)e13-e16(2018 Jan)

Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics.
Naba A, Pearce OMT, Del Rosario A, Ma D, Ding H, Rajeeve V, Cutillas PR, Balkwill FR, Hynes RO
Journal of proteome research16(8)3083-3091(2017 Aug)

Mannose-binding lectin (MBL) codon 54 (rs1800450) polymorphism predisposes towards medium vessel vasculitis in patients with systemic lupus erythematosus.
Negi VS, Devaraju P, Misra DP, Jain VK, Usdadiya JB, Antony PT, Gulati R
Clinical rheumatology36(4)837-843(2017 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Genetic variants in the exon1 of MBL gene per se are not risk factors for Systemic lupus erythematosus (SLE) in South Indian Tamils. However, the association of codon 54 (rs1800450) with medium vessel vasculitis suggests that it may be a genetic modifier of clinical phenotype in SLE.
Title: Mannose-binding lectin (MBL) codon 54 (rs1800450) polymorphism predisposes towards medium vessel vasculitis in patients with systemic lupus erythematosus.

MMP-9 secretion was reduced in the LMAN1 knockout cell line compared to control cells confirming the functional role of LMAN1.
Title: LMAN1 (ERGIC-53) is a potential carrier protein for matrix metalloproteinase-9 glycoprotein secretion.

Mannan-binding lectin reduces CpG DNA-induced inflammatory cytokine production in monocytes.
Title: Mannan-binding lectin reduces CpG DNA-induced inflammatory cytokine production by human monocytes.

Authors identified a class of pathogen-derived ERGIC-53 ligands, a lectin-independent basis for their association with ERGIC-53, and a role for ERGIC-53 in the propagation of several highly pathogenic RNA virus families.
Title: The intracellular cargo receptor ERGIC-53 is required for the production of infectious arenavirus, coronavirus, and filovirus particles.

Studies indicate that the LMAN1-CRD contains distinct, separable binding sites for both its partner protein MCFD2 and the cargo proteins FV/FVIII.
Title: Combined deficiency of coagulation factors V and VIII: an update.

The following LMAN1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the LMAN1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu21047	NM_005570.4 Latest version!	Homo sapiens lectin, mannose binding 1 (LMAN1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
View Old Accession Versions >>
OHu21047	NM_005570.3	Homo sapiens lectin, mannose binding 1 (LMAN1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

LMAN1 ( NM_005570.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_005561.1 Homo sapiens lectin, mannose binding 1 (LMAN1), mRNA.

Price & Availability↑

CloneID	OHu21047
Clone ID Related Accession (Same CDS sequence)	NM_005570.3 , NM_005570.4
Accession Version	NM_005570.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1533bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	protein ERGIC-53 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC308886.1, BC032330.1, U09716.1, AC016229.10, AC067859.7, AK025773.1 and AI280513.1. This sequence is a reference standard in the RefSeqGene project. On Nov 27, 2008 this sequence version replaced NM_005570.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660803.186437.1, SRR1660803.168378.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGGGAT CCAGGCAAAG GGGTCTCCGG GCCAGAGTTC GGCCGCTGTT CTGCGCCTTG 
CTGCTGTCAC TCGGTCGCTT CGTCCGGGGC GACGGCGTGG GAGGAGACCC CGCGGTCGCG 
TTGCCACATC GCCGTTTCGA GTACAAATAC AGCTTCAAGG GGCCGCACCT GGTGCAGAGC 
GACGGGACCG TGCCCTTCTG GGCCCACGCG GGGAATGCTA TTCCAAGTTC AGATCAAATT 
CGAGTAGCAC CATCTTTAAA AAGCCAAAGA GGCTCAGTGT GGACAAAGAC AAAAGCGGCC 
TTTGAGAACT GGGAAGTTGA GGTGACATTT CGAGTGACTG GAAGAGGTCG AATTGGAGCT 
GATGGCCTAG CAATTTGGTA TGCAGAAAAT CAAGGCTTGG AGGGCCCTGT GTTTGGATCA 
GCTGATCTGT GGAATGGTGT TGGAATATTT TTTGATTCTT TTGACAATGA TGGAAAGAAA 
AATAATCCTG CTATAGTAAT TATAGGCAAC AATGGACAAA TCCATTATGA CCATCAAAAT 
GACGGGGCTA GTCAAGCTTT GGCAAGTTGC CAGAGGGACT TCCGCAACAA ACCCTATCCT 
GTCCGAGCAA AGATTACCTA TTACCAGAAC ACACTGACAG TAATGATCAA TAATGGCTTT 
ACACCAGATA AAAATGATTA TGAATTTTGT GCCAAAGTGG AAAATATGAT TATCCCTGCA 
CAAGGGCATT TTGGAATATC TGCTGCAACT GGAGGTCTTG CAGATGACCA TGATGTCCTT 
TCTTTTCTGA CTTTCCAGTT GACTGAACCT GGAAAAGAGC CGCCCACACC AGATAAAGAA 
ATTTCGGAAA AGGAAAAAGA AAAGTATCAG GAGGAATTTG AGCACTTTCA ACAAGAATTG 
GATAAAAAAA AAGAGGAATT CCAGAAGGGC CACCCCGACC TCCAAGGGCA GCCTGCGGAG 
GAAATATTTG AGAGTGTAGG AGATCGAGAG CTAAGACAAG TCTTTGAAGG ACAGAATCGT 
ATTCATCTTG AAATCAAGCA GCTGAACCGG CAGTTAGATA TGATTCTTGA TGAACAGAGA 
AGATATGTCT CTTCCTTAAC AGAGGAAATC TCTAAAAGAG GAGCAGGAAT GCCTGGGCAG 
CATGGGCAGA TTACTCAACA AGAACTGGAT ACTGTTGTGA AAACTCAGCA TGAGATTCTG 
AGACAAGTAA ATGAAATGAA AAATTCCATG AGTGAAACCG TCAGACTGGT CAGTGGAATG 
CAGCACCCTG GCTCTGCTGG AGGCGTCTAT GAGACAACAC AGCACTTCAT TGACATCAAA 
GAGCACCTGC ACATAGTAAA GAGGGACATA GATAACTTAG TGCAGCGAAA TATGCCATCA 
AATGAAAAGC CGAAATGCCC AGAACTACCA CCATTTCCAT CATGTTTGTC TACGGTCCAC 
TTCATTATAT TTGTTGTGGT GCAAACTGTA TTATTCATTG GTTATATCAT GTATAGGTCT 
CAGCAAGAAG CAGCTGCCAA AAAATTCTTT TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005561.1
CDS	33..1565
Translation	MAGSRQRGLRARVRPLFCALLLSLGRFVRGDGVGGDPAVALPHRRFEYKYSFKGPHLVQSDGTVPFWAHAGNAIPSSDQIRVAPSLKSQRGSVWTKTKAAFENWEVEVTFRVTGRGRIGADGLAIWYAENQGLEGPVFGSADLWNGVGIFFDSFDNDGKKNNPAIVIIGNNGQIHYDHQNDGASQALASCQRDFRNKPYPVRAKITYYQNTLTVMINNGFTPDKNDYEFCAKVENMIIPAQGHFGISAATGGLADDHDVLSFLTFQLTEPGKEPPTPDKEISEKEKEKYQEEFEHFQQELDKKKEEFQKGHPDLQGQPAEEIFESVGDRELRQVFEGQNRIHLEIKQLNRQLDMILDEQRRYVSSLTEEISKRGAGMPGQHGQITQQELDTVVKTQHEILRQVNEMKNSMSETVRLVSGMQHPGSAGGVYETTQHFIDIKEHLHIVKRDIDNLVQRNMPSNEKPKCPELPPFPSCLSTVHFIIFVVVQTVLFIGYIMYRSQQEAAAKKFF

Target ORF information:

RefSeq Version	NM_005570.3
Organism	Homo sapiens(human)
Definition	Homo sapiens lectin, mannose binding 1 (LMAN1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005570.3

ORF Insert Sequence:

ATGGCGGGAT CCAGGCAAAG GGGTCTCCGG GCCAGAGTTC GGCCGCTGTT CTGCGCCTTG 
CTGCTGTCAC TCGGTCGCTT CGTCCGGGGC GACGGCGTGG GAGGAGACCC CGCGGTCGCG 
TTGCCACATC GCCGTTTCGA GTACAAATAC AGCTTCAAGG GGCCGCACCT GGTGCAGAGC 
GACGGGACCG TGCCCTTCTG GGCCCACGCG GGGAATGCTA TTCCAAGTTC AGATCAAATT 
CGAGTAGCAC CATCTTTAAA AAGCCAAAGA GGCTCAGTGT GGACAAAGAC AAAAGCGGCC 
TTTGAGAACT GGGAAGTTGA GGTGACATTT CGAGTGACTG GAAGAGGTCG AATTGGAGCT 
GATGGCCTAG CAATTTGGTA TGCAGAAAAT CAAGGCTTGG AGGGCCCTGT GTTTGGATCA 
GCTGATCTGT GGAATGGTGT TGGAATATTT TTTGATTCTT TTGACAATGA TGGAAAGAAA 
AATAATCCTG CTATAGTAAT TATAGGCAAC AATGGACAAA TCCATTATGA CCATCAAAAT 
GACGGGGCTA GTCAAGCTTT GGCAAGTTGC CAGAGGGACT TCCGCAACAA ACCCTATCCT 
GTCCGAGCAA AGATTACCTA TTACCAGAAC ACACTGACAG TAATGATCAA TAATGGCTTT 
ACACCAGATA AAAATGATTA TGAATTTTGT GCCAAAGTGG AAAATATGAT TATCCCTGCA 
CAAGGGCATT TTGGAATATC TGCTGCAACT GGAGGTCTTG CAGATGACCA TGATGTCCTT 
TCTTTTCTGA CTTTCCAGTT GACTGAACCT GGAAAAGAGC CGCCCACACC AGATAAAGAA 
ATTTCGGAAA AGGAAAAAGA AAAGTATCAG GAGGAATTTG AGCACTTTCA ACAAGAATTG 
GATAAAAAAA AAGAGGAATT CCAGAAGGGC CACCCCGACC TCCAAGGGCA GCCTGCGGAG 
GAAATATTTG AGAGTGTAGG AGATCGAGAG CTAAGACAAG TCTTTGAAGG ACAGAATCGT 
ATTCATCTTG AAATCAAGCA GCTGAACCGG CAGTTAGATA TGATTCTTGA TGAACAGAGA 
AGATATGTCT CTTCCTTAAC AGAGGAAATC TCTAAAAGAG GAGCAGGAAT GCCTGGGCAG 
CATGGGCAGA TTACTCAACA AGAACTGGAT ACTGTTGTGA AAACTCAGCA TGAGATTCTG 
AGACAAGTAA ATGAAATGAA AAATTCCATG AGTGAAACCG TCAGACTGGT CAGTGGAATG 
CAGCACCCTG GCTCTGCTGG AGGCGTCTAT GAGACAACAC AGCACTTCAT TGACATCAAA 
GAGCACCTGC ACATAGTAAA GAGGGACATA GATAACTTAG TGCAGCGAAA TATGCCATCA 
AATGAAAAGC CGAAATGCCC AGAACTACCA CCATTTCCAT CATGTTTGTC TACGGTCCAC 
TTCATTATAT TTGTTGTGGT GCAAACTGTA TTATTCATTG GTTATATCAT GTATAGGTCT 
CAGCAAGAAG CAGCTGCCAA AAAATTCTTT TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

LMAN1 ( NM_005570.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_005561.1 Homo sapiens lectin, mannose binding 1 (LMAN1), mRNA.

Price & Availability↑

CloneID	OHu21047
Clone ID Related Accession (Same CDS sequence)	NM_005570.3 , NM_005570.4
Accession Version	NM_005570.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1533bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-26
Organism	Homo sapiens(human)
Product	protein ERGIC-53 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC308886.1, BC032330.1, U09716.1, AC016229.10, AC067859.7, AK025773.1 and AI280513.1. This sequence is a reference standard in the RefSeqGene project. On Nov 23, 2018 this sequence version replaced NM_005570.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660803.186437.1, SRR1660805.147759.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000251047.6/ ENSP00000251047.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCGGGAT CCAGGCAAAG GGGTCTCCGG GCCAGAGTTC GGCCGCTGTT CTGCGCCTTG 
CTGCTGTCAC TCGGTCGCTT CGTCCGGGGC GACGGCGTGG GAGGAGACCC CGCGGTCGCG 
TTGCCACATC GCCGTTTCGA GTACAAATAC AGCTTCAAGG GGCCGCACCT GGTGCAGAGC 
GACGGGACCG TGCCCTTCTG GGCCCACGCG GGGAATGCTA TTCCAAGTTC AGATCAAATT 
CGAGTAGCAC CATCTTTAAA AAGCCAAAGA GGCTCAGTGT GGACAAAGAC AAAAGCGGCC 
TTTGAGAACT GGGAAGTTGA GGTGACATTT CGAGTGACTG GAAGAGGTCG AATTGGAGCT 
GATGGCCTAG CAATTTGGTA TGCAGAAAAT CAAGGCTTGG AGGGCCCTGT GTTTGGATCA 
GCTGATCTGT GGAATGGTGT TGGAATATTT TTTGATTCTT TTGACAATGA TGGAAAGAAA 
AATAATCCTG CTATAGTAAT TATAGGCAAC AATGGACAAA TCCATTATGA CCATCAAAAT 
GACGGGGCTA GTCAAGCTTT GGCAAGTTGC CAGAGGGACT TCCGCAACAA ACCCTATCCT 
GTCCGAGCAA AGATTACCTA TTACCAGAAC ACACTGACAG TAATGATCAA TAATGGCTTT 
ACACCAGATA AAAATGATTA TGAATTTTGT GCCAAAGTGG AAAATATGAT TATCCCTGCA 
CAAGGGCATT TTGGAATATC TGCTGCAACT GGAGGTCTTG CAGATGACCA TGATGTCCTT 
TCTTTTCTGA CTTTCCAGTT GACTGAACCT GGAAAAGAGC CGCCCACACC AGATAAAGAA 
ATTTCGGAAA AGGAAAAAGA AAAGTATCAG GAGGAATTTG AGCACTTTCA ACAAGAATTG 
GATAAAAAAA AAGAGGAATT CCAGAAGGGC CACCCCGACC TCCAAGGGCA GCCTGCGGAG 
GAAATATTTG AGAGTGTAGG AGATCGAGAG CTAAGACAAG TCTTTGAAGG ACAGAATCGT 
ATTCATCTTG AAATCAAGCA GCTGAACCGG CAGTTAGATA TGATTCTTGA TGAACAGAGA 
AGATATGTCT CTTCCTTAAC AGAGGAAATC TCTAAAAGAG GAGCAGGAAT GCCTGGGCAG 
CATGGGCAGA TTACTCAACA AGAACTGGAT ACTGTTGTGA AAACTCAGCA TGAGATTCTG 
AGACAAGTAA ATGAAATGAA AAATTCCATG AGTGAAACCG TCAGACTGGT CAGTGGAATG 
CAGCACCCTG GCTCTGCTGG AGGCGTCTAT GAGACAACAC AGCACTTCAT TGACATCAAA 
GAGCACCTGC ACATAGTAAA GAGGGACATA GATAACTTAG TGCAGCGAAA TATGCCATCA 
AATGAAAAGC CGAAATGCCC AGAACTACCA CCATTTCCAT CATGTTTGTC TACGGTCCAC 
TTCATTATAT TTGTTGTGGT GCAAACTGTA TTATTCATTG GTTATATCAT GTATAGGTCT 
CAGCAAGAAG CAGCTGCCAA AAAATTCTTT TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005561.1
CDS	22..1554
Translation	MAGSRQRGLRARVRPLFCALLLSLGRFVRGDGVGGDPAVALPHRRFEYKYSFKGPHLVQSDGTVPFWAHAGNAIPSSDQIRVAPSLKSQRGSVWTKTKAAFENWEVEVTFRVTGRGRIGADGLAIWYAENQGLEGPVFGSADLWNGVGIFFDSFDNDGKKNNPAIVIIGNNGQIHYDHQNDGASQALASCQRDFRNKPYPVRAKITYYQNTLTVMINNGFTPDKNDYEFCAKVENMIIPAQGHFGISAATGGLADDHDVLSFLTFQLTEPGKEPPTPDKEISEKEKEKYQEEFEHFQQELDKKKEEFQKGHPDLQGQPAEEIFESVGDRELRQVFEGQNRIHLEIKQLNRQLDMILDEQRRYVSSLTEEISKRGAGMPGQHGQITQQELDTVVKTQHEILRQVNEMKNSMSETVRLVSGMQHPGSAGGVYETTQHFIDIKEHLHIVKRDIDNLVQRNMPSNEKPKCPELPPFPSCLSTVHFIIFVVVQTVLFIGYIMYRSQQEAAAKKFF

Target ORF information:

RefSeq Version	NM_005570.4
Organism	Homo sapiens(human)
Definition	Homo sapiens lectin, mannose binding 1 (LMAN1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005570.4

ORF Insert Sequence:

ATGGCGGGAT CCAGGCAAAG GGGTCTCCGG GCCAGAGTTC GGCCGCTGTT CTGCGCCTTG 
CTGCTGTCAC TCGGTCGCTT CGTCCGGGGC GACGGCGTGG GAGGAGACCC CGCGGTCGCG 
TTGCCACATC GCCGTTTCGA GTACAAATAC AGCTTCAAGG GGCCGCACCT GGTGCAGAGC 
GACGGGACCG TGCCCTTCTG GGCCCACGCG GGGAATGCTA TTCCAAGTTC AGATCAAATT 
CGAGTAGCAC CATCTTTAAA AAGCCAAAGA GGCTCAGTGT GGACAAAGAC AAAAGCGGCC 
TTTGAGAACT GGGAAGTTGA GGTGACATTT CGAGTGACTG GAAGAGGTCG AATTGGAGCT 
GATGGCCTAG CAATTTGGTA TGCAGAAAAT CAAGGCTTGG AGGGCCCTGT GTTTGGATCA 
GCTGATCTGT GGAATGGTGT TGGAATATTT TTTGATTCTT TTGACAATGA TGGAAAGAAA 
AATAATCCTG CTATAGTAAT TATAGGCAAC AATGGACAAA TCCATTATGA CCATCAAAAT 
GACGGGGCTA GTCAAGCTTT GGCAAGTTGC CAGAGGGACT TCCGCAACAA ACCCTATCCT 
GTCCGAGCAA AGATTACCTA TTACCAGAAC ACACTGACAG TAATGATCAA TAATGGCTTT 
ACACCAGATA AAAATGATTA TGAATTTTGT GCCAAAGTGG AAAATATGAT TATCCCTGCA 
CAAGGGCATT TTGGAATATC TGCTGCAACT GGAGGTCTTG CAGATGACCA TGATGTCCTT 
TCTTTTCTGA CTTTCCAGTT GACTGAACCT GGAAAAGAGC CGCCCACACC AGATAAAGAA 
ATTTCGGAAA AGGAAAAAGA AAAGTATCAG GAGGAATTTG AGCACTTTCA ACAAGAATTG 
GATAAAAAAA AAGAGGAATT CCAGAAGGGC CACCCCGACC TCCAAGGGCA GCCTGCGGAG 
GAAATATTTG AGAGTGTAGG AGATCGAGAG CTAAGACAAG TCTTTGAAGG ACAGAATCGT 
ATTCATCTTG AAATCAAGCA GCTGAACCGG CAGTTAGATA TGATTCTTGA TGAACAGAGA 
AGATATGTCT CTTCCTTAAC AGAGGAAATC TCTAAAAGAG GAGCAGGAAT GCCTGGGCAG 
CATGGGCAGA TTACTCAACA AGAACTGGAT ACTGTTGTGA AAACTCAGCA TGAGATTCTG 
AGACAAGTAA ATGAAATGAA AAATTCCATG AGTGAAACCG TCAGACTGGT CAGTGGAATG 
CAGCACCCTG GCTCTGCTGG AGGCGTCTAT GAGACAACAC AGCACTTCAT TGACATCAAA 
GAGCACCTGC ACATAGTAAA GAGGGACATA GATAACTTAG TGCAGCGAAA TATGCCATCA 
AATGAAAAGC CGAAATGCCC AGAACTACCA CCATTTCCAT CATGTTTGTC TACGGTCCAC 
TTCATTATAT TTGTTGTGGT GCAAACTGTA TTATTCATTG GTTATATCAT GTATAGGTCT 
CAGCAAGAAG CAGCTGCCAA AAAATTCTTT TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Combined deficiency of factors V and VIII by chance coinheritance of parahaemophilia and haemophilia A, but not by mutations of either LMAN1 or MCFD2, in a Japanese family.
Haemophilia : the official journal of the World Federation of Hemophilia24(1)e13-e16(2018 Jan)
Suzuki S,Nakamura Y,Suzuki N,Yamazaki T,Takagi Y,Tamura S,Takagi A,Kanematsu T,Matsushita T,Kojima T

Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics.
Journal of proteome research16(8)3083-3091(2017 Aug)
Naba A,Pearce OMT,Del Rosario A,Ma D,Ding H,Rajeeve V,Cutillas PR,Balkwill FR,Hynes RO

Mannose-binding lectin (MBL) codon 54 (rs1800450) polymorphism predisposes towards medium vessel vasculitis in patients with systemic lupus erythematosus.
Clinical rheumatology36(4)837-843(2017 Apr)
Negi VS,Devaraju P,Misra DP,Jain VK,Usdadiya JB,Antony PT,Gulati R

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LMAN1 cDNA ORF clone, Homo sapiens(human)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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