ARHGDIG cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	ARHGDIG
Entrez Gene ID	398
Full Name	Rho GDP dissociation inhibitor gamma
Synonyms	RHOGDI-3
General protein information	Preferred Names Rho GDP dissociation inhibitor gamma Names rho GDP-dissociation inhibitor 3 Rho GDP dissociation inhibitor (GDI) gamma RhoGDI gamma rho GDI 3 rho-GDI gamma
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 16 Map Location: 16p13.3
Summary	The GDP-dissociation inhibitors (GDIs) play a primary role in modulating the activation of GTPases by inhibiting the exchange of GDP for GTP. See ARHGDIB (MIM 602843).[supplied by OMIM, Nov 2010].
Disorder MIM:	602844

mRNA and Protein(s)

mRNA	Protein	Name
NM_001176.4	NP_001167.2	rho GDP-dissociation inhibitor 3
NM_001176.3	NP_001167.2	rho GDP-dissociation inhibitor 3

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Arhgdig	NP_032139.1
Homo sapiens (human)	ARHGDIG	NP_001167.2
Pan troglodytes (chimpanzee)	ARHGDIG	XP_001171621.1
	ARHGDIG	XP_001118456.2
Canis lupus familiaris (dog)	ARHGDIG	XP_005621818.1
Bos taurus (cattle)	ARHGDIG	NP_001069754.1
Rattus norvegicus (Norway rat)	Arhgdig	NP_001101739.1
Gallus gallus (chicken)	ARHGDIG	XP_003642211.1
Xenopus tropicalis (tropical clawed frog)	arhgdig	NP_001007516.1

Gene Ontology
Bibliography

Related articles in PubMed

Immunological and Functional Characterization of RhoGDI3 and Its Molecular Targets RhoG and RhoB in Human Pancreatic Cancerous and Normal Cells.
de Le?n-Bautista MP, Cardenas-Aguayo MD, Casique-Aguirre D, Almaraz-Salinas M, Parraguirre-Martinez S, Olivo-Diaz A, Thompson-Bonilla MD, Vargas M
PloS one11(11)e0166370(2016)

Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method.
Oshikawa M, Tsutsui C, Ikegami T, Fuchida Y, Matsubara M, Toyama S, Usami R, Ohtoko K, Kato S
Investigative ophthalmology & visual science52(9)6662-70(2011 Aug)

Application of gene network analysis techniques identifies AXIN1/PDIA2 and endoglin haplotypes associated with bicuspid aortic valve.
Wooten EC, Iyer LK, Montefusco MC, Hedgepeth AK, Payne DD, Kapur NK, Housman DE, Mendelsohn ME, Huggins GS
PloS one5(1)e8830(2010 Jan)

Uncoupling of inhibitory and shuttling functions of rho GDP dissociation inhibitors.
Dransart E, Morin A, Cherfils J, Olofsson B
The Journal of biological chemistry280(6)4674-83(2005 Feb)

The sequence and analysis of duplication-rich human chromosome 16.
Martin J, Han C, Gordon LA, Terry A, Prabhakar S, She X, Xie G, Hellsten U, Chan YM, Altherr M, Couronne O, Aerts A, Bajorek E, Black S, Blumer H, Branscomb E, Brown NC, Bruno WJ, Buckingham JM, Callen DF, Campbell CS, Campbell ML, Campbell EW, Caoile C, Challacombe JF, Chasteen LA, Chertkov O, Chi HC, Christensen M, Clark LM, Cohn JD, Denys M, Detter JC, Dickson M, Dimitrijevic-Bussod M, Escobar J, Fawcett JJ, Flowers D, Fotopulos D, Glavina T, Gomez M, Gonzales E, Goodstein D, Goodwin LA, Grady DL, Grigoriev I, Groza M, Hammon N, Hawkins T, Haydu L, Hildebrand CE, Huang W, Israni S, Jett J, Jewett PB, Kadner K, Kimball H, Kobayashi A, Krawczyk MC, Leyba T, Longmire JL, Lopez F, Lou Y, Lowry S, Ludeman T, Manohar CF, Mark GA, McMurray KL, Meincke LJ, Morgan J, Moyzis RK, Mundt MO, Munk AC, Nandkeshwar RD, Pitluck S, Pollard M, Predki P, Parson-Quintana B, Ramirez L, Rash S, Retterer J, Ricke DO, Robinson DL, Rodriguez A, Salamov A, Saunders EH, Scott D, Shough T, Stallings RL, Stalvey M, Sutherland RD, Tapia R, Tesmer JG, Thayer N, Thompson LS, Tice H, Torney DC, Tran-Gyamfi M, Tsai M, Ulanovsky LE, Ustaszewska A, Vo N, White PS, Williams AL, Wills PL, Wu JR, Wu K, Yang J, Dejong P, Bruce D, Doggett NA, Deaven L, Schmutz J, Grimwood J, Richardson P, Rokhsar DS, Eichler EE, Gilna P, Lucas SM, Myers RM, Rubin EM, Pennacchio LA
Nature432(7020)988-94(2004 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These results suggest that the levels of RhoG and RhoB GTPases and their negative regulator RhoGDI3 might be linked to the aggressiveness of the pancreatic cancerous cell lines. It is possible that RhoGDI3 could induce the downregulation of RhoG and RhoB.
Title: Immunological and Functional Characterization of RhoGDI3 and Its Molecular Targets RhoG and RhoB in Human Pancreatic Cancerous and Normal Cells.

Observational study of gene-disease association. (HuGE Navigator)
Title: Application of gene network analysis techniques identifies AXIN1/PDIA2 and endoglin haplotypes associated with bicuspid aortic valve.

analysis of inhibitory and shuttling functions of rhoGDI-3 and rhoGDI-1
Title: Uncoupling of inhibitory and shuttling functions of rho GDP dissociation inhibitors.

The following ARHGDIG gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ARHGDIG cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu31330	NM_001176.4 Latest version!	Homo sapiens Rho GDP dissociation inhibitor gamma (ARHGDIG), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu31330	NM_001176.3	Homo sapiens Rho GDP dissociation inhibitor gamma (ARHGDIG), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

ARHGDIG ( NM_001176.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_001167.2 Homo sapiens Rho GDP dissociation inhibitor gamma (ARHGDIG), mRNA.

Price & Availability↑

CloneID	OHu31330
Clone ID Related Accession (Same CDS sequence)	NM_001176.4 , NM_001176.3
Accession Version	NM_001176.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 678bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	rho GDP-dissociation inhibitor 3
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from Z69667.1, BC047699.1 and BM662457.1. On Nov 22, 2018 this sequence version replaced NM_001176.3. ##Evidence-Data-START## Transcript exon combination :: AB593111.1, ERR279844.8487.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1968968 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000219409.8/ ENSP00000219409.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCTGGGCC TGGACGCGTG CGAGCTGGGG GCGCAGCTGC TGGAGCTGCT CCGGCTGGCG 
CTGTGCGCCC GAGTCCTCCT GGCTGACAAG GAGGGTGGGC CGCCGGCAGT GGACGAGGTG 
TTGGATGAGG CTGTGCCCGA GTACCGGGCG CCGGGGAGGA AGAGCCTCTT GGAGATCCGG 
CAGCTGGACC CGGACGACAG GAGCCTGGCC AAGTACAAGC GGGTGCTGCT GGGGCCCCTG 
CCACCGGCCG TGGACCCAAG CCTGCCCAAT GTGCAGGTGA CCAGGCTGAC ACTCCTGTCG 
GAACAGGCTC CGGGGCCCGT CGTCATGGAT CTCACAGGGG ACCTGGCTGT TCTGAAGGAC 
CAGGTGTTTG TCCTGAAGGA AGGTGTTGAT TACAGAGTGA AGATCTCCTT CAAGGTCCAC 
AGGGAGATTG TCAGCGGCCT CAAGTGTCTG CACCACACCT ACCGCCGGGG CCTGCGCGTG 
GACAAGACCG TCTACATGGT GGGCAGCTAT GGCCCGAGCG CCCAGGAGTA TGAGTTTGTG 
ACTCCGGTGG AGGAAGCGCC GAGGGGTGCG CTGGTGCGGG GCCCCTATCT GGTGGTGTCC 
CTCTTCACCG ACGATGACAG GACGCACCAC CTGTCCTGGG AGTGGGGTCT CTGCATCTGC 
CAGGACTGGA AGGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001167.2
CDS	91..768
Translation	MLGLDACELGAQLLELLRLALCARVLLADKEGGPPAVDEVLDEAVPEYRAPGRKSLLEIRQLDPDDRSLAKYKRVLLGPLPPAVDPSLPNVQVTRLTLLSEQAPGPVVMDLTGDLAVLKDQVFVLKEGVDYRVKISFKVHREIVSGLKCLHHTYRRGLRVDKTVYMVGSYGPSAQEYEFVTPVEEAPRGALVRGPYLVVSLFTDDDRTHHLSWEWGLCICQDWKD

Target ORF information:

RefSeq Version	NM_001176.4
Organism	Homo sapiens(human)
Definition	Homo sapiens Rho GDP dissociation inhibitor gamma (ARHGDIG), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001176.4

ORF Insert Sequence:

ATGCTGGGCC TGGACGCGTG CGAGCTGGGG GCGCAGCTGC TGGAGCTGCT CCGGCTGGCG 
CTGTGCGCCC GAGTCCTCCT GGCTGACAAG GAGGGTGGGC CGCCGGCAGT GGACGAGGTG 
TTGGATGAGG CTGTGCCCGA GTACCGGGCG CCGGGGAGGA AGAGCCTCTT GGAGATCCGG 
CAGCTGGACC CGGACGACAG GAGCCTGGCC AAGTACAAGC GGGTGCTGCT GGGGCCCCTG 
CCACCGGCCG TGGACCCAAG CCTGCCCAAT GTGCAGGTGA CCAGGCTGAC ACTCCTGTCG 
GAACAGGCTC CGGGGCCCGT CGTCATGGAT CTCACAGGGG ACCTGGCTGT TCTGAAGGAC 
CAGGTGTTTG TCCTGAAGGA AGGTGTTGAT TACAGAGTGA AGATCTCCTT CAAGGTCCAC 
AGGGAGATTG TCAGCGGCCT CAAGTGTCTG CACCACACCT ACCGCCGGGG CCTGCGCGTG 
GACAAGACCG TCTACATGGT GGGCAGCTAT GGCCCGAGCG CCCAGGAGTA TGAGTTTGTG 
ACTCCGGTGG AGGAAGCGCC GAGGGGTGCG CTGGTGCGGG GCCCCTATCT GGTGGTGTCC 
CTCTTCACCG ACGATGACAG GACGCACCAC CTGTCCTGGG AGTGGGGTCT CTGCATCTGC 
CAGGACTGGA AGGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ARHGDIG ( NM_001176.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001167.2 Homo sapiens Rho GDP dissociation inhibitor gamma (ARHGDIG), mRNA.

Price & Availability↑

CloneID	OHu31330
Clone ID Related Accession (Same CDS sequence)	NM_001176.4 , NM_001176.3
Accession Version	NM_001176.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 678bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	rho GDP-dissociation inhibitor 3
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC047699.1, Z69667.1 and BM662457.1. On Aug 27, 2008 this sequence version replaced NM_001176.2. ##Evidence-Data-START## Transcript exon combination :: BC047699.1, AB593111.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1968968 [ECO:0000348] ##Evidence-Data-END##

ATGCTGGGCC TGGACGCGTG CGAGCTGGGG GCGCAGCTGC TGGAGCTGCT CCGGCTGGCG 
CTGTGCGCCC GAGTCCTCCT GGCTGACAAG GAGGGTGGGC CGCCGGCAGT GGACGAGGTG 
TTGGATGAGG CTGTGCCCGA GTACCGGGCG CCGGGGAGGA AGAGCCTCTT GGAGATCCGG 
CAGCTGGACC CGGACGACAG GAGCCTGGCC AAGTACAAGC GGGTGCTGCT GGGGCCCCTG 
CCACCGGCCG TGGACCCAAG CCTGCCCAAT GTGCAGGTGA CCAGGCTGAC ACTCCTGTCG 
GAACAGGCTC CGGGGCCCGT CGTCATGGAT CTCACAGGGG ACCTGGCTGT TCTGAAGGAC 
CAGGTGTTTG TCCTGAAGGA AGGTGTTGAT TACAGAGTGA AGATCTCCTT CAAGGTCCAC 
AGGGAGATTG TCAGCGGCCT CAAGTGTCTG CACCACACCT ACCGCCGGGG CCTGCGCGTG 
GACAAGACCG TCTACATGGT GGGCAGCTAT GGCCCGAGCG CCCAGGAGTA TGAGTTTGTG 
ACTCCGGTGG AGGAAGCGCC GAGGGGTGCG CTGGTGCGGG GCCCCTATCT GGTGGTGTCC 
CTCTTCACCG ACGATGACAG GACGCACCAC CTGTCCTGGG AGTGGGGTCT CTGCATCTGC 
CAGGACTGGA AGGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001167.2
CDS	76..753
Translation	MLGLDACELGAQLLELLRLALCARVLLADKEGGPPAVDEVLDEAVPEYRAPGRKSLLEIRQLDPDDRSLAKYKRVLLGPLPPAVDPSLPNVQVTRLTLLSEQAPGPVVMDLTGDLAVLKDQVFVLKEGVDYRVKISFKVHREIVSGLKCLHHTYRRGLRVDKTVYMVGSYGPSAQEYEFVTPVEEAPRGALVRGPYLVVSLFTDDDRTHHLSWEWGLCICQDWKD

Target ORF information:

RefSeq Version	NM_001176.3
Organism	Homo sapiens(human)
Definition	Homo sapiens Rho GDP dissociation inhibitor gamma (ARHGDIG), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001176.3

ORF Insert Sequence:

ATGCTGGGCC TGGACGCGTG CGAGCTGGGG GCGCAGCTGC TGGAGCTGCT CCGGCTGGCG 
CTGTGCGCCC GAGTCCTCCT GGCTGACAAG GAGGGTGGGC CGCCGGCAGT GGACGAGGTG 
TTGGATGAGG CTGTGCCCGA GTACCGGGCG CCGGGGAGGA AGAGCCTCTT GGAGATCCGG 
CAGCTGGACC CGGACGACAG GAGCCTGGCC AAGTACAAGC GGGTGCTGCT GGGGCCCCTG 
CCACCGGCCG TGGACCCAAG CCTGCCCAAT GTGCAGGTGA CCAGGCTGAC ACTCCTGTCG 
GAACAGGCTC CGGGGCCCGT CGTCATGGAT CTCACAGGGG ACCTGGCTGT TCTGAAGGAC 
CAGGTGTTTG TCCTGAAGGA AGGTGTTGAT TACAGAGTGA AGATCTCCTT CAAGGTCCAC 
AGGGAGATTG TCAGCGGCCT CAAGTGTCTG CACCACACCT ACCGCCGGGG CCTGCGCGTG 
GACAAGACCG TCTACATGGT GGGCAGCTAT GGCCCGAGCG CCCAGGAGTA TGAGTTTGTG 
ACTCCGGTGG AGGAAGCGCC GAGGGGTGCG CTGGTGCGGG GCCCCTATCT GGTGGTGTCC 
CTCTTCACCG ACGATGACAG GACGCACCAC CTGTCCTGGG AGTGGGGTCT CTGCATCTGC 
CAGGACTGGA AGGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Immunological and Functional Characterization of RhoGDI3 and Its Molecular Targets RhoG and RhoB in Human Pancreatic Cancerous and Normal Cells.
PloS one11(11)e0166370(2016)
de Le?n-Bautista MP,Cardenas-Aguayo MD,Casique-Aguirre D,Almaraz-Salinas M,Parraguirre-Martinez S,Olivo-Diaz A,Thompson-Bonilla MD,Vargas M

Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method.
Investigative ophthalmology & visual science52(9)6662-70(2011 Aug)
Oshikawa M,Tsutsui C,Ikegami T,Fuchida Y,Matsubara M,Toyama S,Usami R,Ohtoko K,Kato S

Application of gene network analysis techniques identifies AXIN1/PDIA2 and endoglin haplotypes associated with bicuspid aortic valve.
PloS one5(1)e8830(2010 Jan)
Wooten EC,Iyer LK,Montefusco MC,Hedgepeth AK,Payne DD,Kapur NK,Housman DE,Mendelsohn ME,Huggins GS

Uncoupling of inhibitory and shuttling functions of rho GDP dissociation inhibitors.
The Journal of biological chemistry280(6)4674-83(2005 Feb)
Dransart E,Morin A,Cherfils J,Olofsson B

The sequence and analysis of duplication-rich human chromosome 16.
Nature432(7020)988-94(2004 Dec)
Martin J,Han C,Gordon LA,Terry A,Prabhakar S,She X,Xie G,Hellsten U,Chan YM,Altherr M,Couronne O,Aerts A,Bajorek E,Black S,Blumer H,Branscomb E,Brown NC,Bruno WJ,Buckingham JM,Callen DF,Campbell CS,Campbell ML,Campbell EW,Caoile C,Challacombe JF,Chasteen LA,Chertkov O,Chi HC,Christensen M,Clark LM,Cohn JD,Denys M,Detter JC,Dickson M,Dimitrijevic-Bussod M,Escobar J,Fawcett JJ,Flowers D,Fotopulos D,Glavina T,Gomez M,Gonzales E,Goodstein D,Goodwin LA,Grady DL,Grigoriev I,Groza M,Hammon N,Hawkins T,Haydu L,Hildebrand CE,Huang W,Israni S,Jett J,Jewett PB,Kadner K,Kimball H,Kobayashi A,Krawczyk MC,Leyba T,Longmire JL,Lopez F,Lou Y,Lowry S,Ludeman T,Manohar CF,Mark GA,McMurray KL,Meincke LJ,Morgan J,Moyzis RK,Mundt MO,Munk AC,Nandkeshwar RD,Pitluck S,Pollard M,Predki P,Parson-Quintana B,Ramirez L,Rash S,Retterer J,Ricke DO,Robinson DL,Rodriguez A,Salamov A,Saunders EH,Scott D,Shough T,Stallings RL,Stalvey M,Sutherland RD,Tapia R,Tesmer JG,Thayer N,Thompson LS,Tice H,Torney DC,Tran-Gyamfi M,Tsai M,Ulanovsky LE,Ustaszewska A,Vo N,White PS,Williams AL,Wills PL,Wu JR,Wu K,Yang J,Dejong P,Bruce D,Doggett NA,Deaven L,Schmutz J,Grimwood J,Richardson P,Rokhsar DS,Eichler EE,Gilna P,Lucas SM,Myers RM,Rubin EM,Pennacchio LA

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ARHGDIG cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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