LHB cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	LHB
Entrez Gene ID	3972
Full Name	luteinizing hormone beta polypeptide
Synonyms	CGB4,HH23,LSH-B,LSH-beta
General protein information	Preferred Names luteinizing hormone beta polypeptide Names lutropin subunit beta interstitial cell stimulating hormone, beta chain luteinizing hormone beta subunit lutropin beta chain
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 19 Map Location: 19q13.33
Summary	This gene is a member of the glycoprotein hormone beta chain family and encodes the beta subunit of luteinizing hormone (LH). Glycoprotein hormones are heterodimers consisting of a common alpha subunit and an unique beta subunit which confers biological specificity. LH is expressed in the pituitary gland and promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids. The genes for the beta chains of chorionic gonadotropin and for luteinizing hormone are contiguous on chromosome 19q13.3. Mutations in this gene are associated with hypogonadism which is characterized by infertility and pseudohermaphroditism. [provided by RefSeq, Jul 2008].
Disorder MIM:	152780
Disorder Html:	Hypogonadotropic hypogonadism 23 with or without anosmia, 228300 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_000894.3	NP_000885.1	lutropin subunit beta precursor
NM_000894.2	NP_000885.1	lutropin subunit beta precursor
XM_011526975.1	XP_011525277.1	lutropin subunit beta isoform X1

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Lhb	NP_036990.1
Homo sapiens (human)	LHB	NP_000885.1
	LOC100429401	XP_002801383.1
Mus musculus (house mouse)	Lhb	NP_032523.2
Danio rerio (zebrafish)	lhb	NP_991185.1
Xenopus tropicalis (tropical clawed frog)	LOC100490615	XP_002939281.1
Pan troglodytes (chimpanzee)	LHB	NP_001065271.1
Canis lupus familiaris (dog)	LHB	NP_001183962.1
Bos taurus (cattle)	LHB	NP_776355.1

Gene Ontology
Bibliography

Related articles in PubMed

A vital region for human glycoprotein hormone trafficking revealed by an LHB mutation.
Potorac I, Rivero-M?ller A, Trehan A, Kie?bus M, Jozwiak K, Pralong F, Hafidi A, Thiry A, M?nag? JJ, Huhtaniemi I, Beckers A, Daly AF
The Journal of endocrinology231(3)197-207(2016 Dec)

Luteinizing Hormone Secretion during Gonadotropin-Releasing Hormone Stimulation Tests in Obese Girls with Central Precocious Puberty.
Lee HS, Yoon JS, Hwang JS
Journal of clinical research in pediatric endocrinology8(4)392-398(2016 12)

A receptor-binding region in human choriogonadotropin/lutropin beta subunit.
Keutmann HT, Charlesworth MC, Mason KA, Ostrea T, Johnson L, Ryan RJ
Proceedings of the National Academy of Sciences of the United States of America84(7)2038-42(1987 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

A 20-year-old male from a consanguineous family had pubertal delay, hypogonadism and undetectable LH. A homozygous c.118_120del (p.Lys40del) mutation was identified in the patient and his brother, who subsequently had the same phenotype.
Title: A vital region for human glycoprotein hormone trafficking revealed by an LHB mutation.

In girls with central precocious puberty, increased body mass index (BMI) was associated with slightly lower peak stimulated luteinizing hormone (LH) levels at early pubertal stages (Tanner stages 2 and 3).
Title: Luteinizing Hormone Secretion during Gonadotropin-Releasing Hormone Stimulation Tests in Obese Girls with Central Precocious Puberty.

LHbeta G1052A and LHCGR G935A genes polymorphisms are associated with increased risk of polycystic ovary syndrome in Egyptian women especially in obese cases.
Title: Association between genes encoding components of the Leutinizing hormone/Luteinizing hormone-choriogonadotrophin receptor pathway and polycystic ovary syndrome in Egyptian women.

The Trp8Arg/Ile15Thr polymorphism within the LHB gene was not associated with endometriosis and infertility.
Title: LH (Trp8Arg/Ile15Thr), LHR (insLQ) and FSHR (Asn680Ser) polymorphisms genotypic prevalence in women with endometriosis and infertility.

This paper shows a conclusive contribution of Variant-Luteinizing hormone to the natural variance in male serum Luteinizing hormone levels
Title: 'Carriers of variant luteinizing hormone (V-LH) among 1593 Baltic men have significantly higher serum LH'.

The following LHB gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the LHB cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu19581	NM_000894.3 Latest version!	Homo sapiens luteinizing hormone subunit beta (LHB), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu58703	XM_011526975.1 Latest version!	Homo sapiens luteinizing hormone beta polypeptide (LHB), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
View Old Accession Versions >>
OHu19581	NM_000894.2	Homo sapiens luteinizing hormone beta polypeptide (LHB), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

LHB ( NM_000894.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_000885.1 Homo sapiens luteinizing hormone subunit beta (LHB), mRNA.

Price & Availability↑

CloneID	OHu19581
Clone ID Related Accession (Same CDS sequence)	NM_000894.3 , NM_000894.2
Accession Version	NM_000894.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 426bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-19
Organism	Homo sapiens(human)
Product	lutropin subunit beta precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC008687.5. On Oct 15, 2019 this sequence version replaced NM_000894.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: CD107666.1, ERR3218367.539597.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGAGATGC TCCAGGGGCT GCTGCTGTTG CTGCTGCTGA GCATGGGCGG GGCATGGGCA 
TCCAGGGAGC CGCTTCGGCC ATGGTGCCAC CCCATCAATG CCATCCTGGC TGTCGAGAAG 
GAGGGCTGCC CAGTGTGCAT CACCGTCAAC ACCACCATCT GTGCCGGCTA CTGCCCCACC 
ATGATGCGCG TGCTGCAGGC GGTCCTGCCG CCCCTGCCTC AGGTGGTGTG CACCTACCGT 
GATGTGCGCT TCGAGTCCAT CCGGCTCCCT GGCTGCCCGC GTGGTGTGGA CCCCGTGGTC 
TCCTTCCCTG TGGCTCTCAG CTGTCGCTGT GGACCCTGCC GCCGCAGCAC CTCTGACTGT 
GGGGGTCCCA AAGACCACCC CTTGACCTGT GACCACCCCC AACTCTCAGG CCTCCTCTTC 
CTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000885.1
CDS	11..436
Translation	MEMLQGLLLLLLLSMGGAWASREPLRPWCHPINAILAVEKEGCPVCITVNTTICAGYCPTMMRVLQAVLPPLPQVVCTYRDVRFESIRLPGCPRGVDPVVSFPVALSCRCGPCRRSTSDCGGPKDHPLTCDHPQLSGLLFL

Target ORF information:

RefSeq Version	NM_000894.3
Organism	Homo sapiens(human)
Definition	Homo sapiens luteinizing hormone subunit beta (LHB), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000894.3

ORF Insert Sequence:

ATGGAGATGC TCCAGGGGCT GCTGCTGTTG CTGCTGCTGA GCATGGGCGG GGCATGGGCA 
TCCAGGGAGC CGCTTCGGCC ATGGTGCCAC CCCATCAATG CCATCCTGGC TGTCGAGAAG 
GAGGGCTGCC CAGTGTGCAT CACCGTCAAC ACCACCATCT GTGCCGGCTA CTGCCCCACC 
ATGATGCGCG TGCTGCAGGC GGTCCTGCCG CCCCTGCCTC AGGTGGTGTG CACCTACCGT 
GATGTGCGCT TCGAGTCCAT CCGGCTCCCT GGCTGCCCGC GTGGTGTGGA CCCCGTGGTC 
TCCTTCCCTG TGGCTCTCAG CTGTCGCTGT GGACCCTGCC GCCGCAGCAC CTCTGACTGT 
GGGGGTCCCA AAGACCACCC CTTGACCTGT GACCACCCCC AACTCTCAGG CCTCCTCTTC 
CTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

LHB ( NM_000894.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_000885.1 Homo sapiens luteinizing hormone beta polypeptide (LHB), mRNA.

Price & Availability↑

CloneID	OHu19581
Clone ID Related Accession (Same CDS sequence)	NM_000894.3 , NM_000894.2
Accession Version	NM_000894.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 426bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-03
Organism	Homo sapiens(human)
Product	lutropin subunit beta precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from X00264.1. This sequence is a reference standard in the RefSeqGene project. On Sep 5, 2001 this sequence version replaced NM_000894.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: ERR279843.303.1, CD107666.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2148874 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGAGATGC TCCAGGGGCT GCTGCTGTTG CTGCTGCTGA GCATGGGCGG GGCATGGGCA 
TCCAGGGAGC CGCTTCGGCC ATGGTGCCAC CCCATCAATG CCATCCTGGC TGTCGAGAAG 
GAGGGCTGCC CAGTGTGCAT CACCGTCAAC ACCACCATCT GTGCCGGCTA CTGCCCCACC 
ATGATGCGCG TGCTGCAGGC GGTCCTGCCG CCCCTGCCTC AGGTGGTGTG CACCTACCGT 
GATGTGCGCT TCGAGTCCAT CCGGCTCCCT GGCTGCCCGC GTGGTGTGGA CCCCGTGGTC 
TCCTTCCCTG TGGCTCTCAG CTGTCGCTGT GGACCCTGCC GCCGCAGCAC CTCTGACTGT 
GGGGGTCCCA AAGACCACCC CTTGACCTGT GACCACCCCC AACTCTCAGG CCTCCTCTTC 
CTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000885.1
CDS	10..435
Translation	MEMLQGLLLLLLLSMGGAWASREPLRPWCHPINAILAVEKEGCPVCITVNTTICAGYCPTMMRVLQAVLPPLPQVVCTYRDVRFESIRLPGCPRGVDPVVSFPVALSCRCGPCRRSTSDCGGPKDHPLTCDHPQLSGLLFL

Target ORF information:

RefSeq Version	NM_000894.2
Organism	Homo sapiens(human)
Definition	Homo sapiens luteinizing hormone beta polypeptide (LHB), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000894.2

ORF Insert Sequence:

ATGGAGATGC TCCAGGGGCT GCTGCTGTTG CTGCTGCTGA GCATGGGCGG GGCATGGGCA 
TCCAGGGAGC CGCTTCGGCC ATGGTGCCAC CCCATCAATG CCATCCTGGC TGTCGAGAAG 
GAGGGCTGCC CAGTGTGCAT CACCGTCAAC ACCACCATCT GTGCCGGCTA CTGCCCCACC 
ATGATGCGCG TGCTGCAGGC GGTCCTGCCG CCCCTGCCTC AGGTGGTGTG CACCTACCGT 
GATGTGCGCT TCGAGTCCAT CCGGCTCCCT GGCTGCCCGC GTGGTGTGGA CCCCGTGGTC 
TCCTTCCCTG TGGCTCTCAG CTGTCGCTGT GGACCCTGCC GCCGCAGCAC CTCTGACTGT 
GGGGGTCCCA AAGACCACCC CTTGACCTGT GACCACCCCC AACTCTCAGG CCTCCTCTTC 
CTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

LHB ( XM_011526975.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_011525277.1 Homo sapiens luteinizing hormone beta polypeptide (LHB), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu58703
Clone ID Related Accession (Same CDS sequence)	XM_011526975.1
Accession Version	XM_011526975.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 474bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-06-12
Organism	Homo sapiens(human)
Product	lutropin subunit beta isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000019.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20190607 Annotation Version :: 109.20190607 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Freeze :: 20190607 ##Genome-Annotation-Data-END##

ATGGGAAGGC CAGGACTCGG GGCTGCGGTC TCAGACCTGG GTGAAGCAGT GTCCTTGTCC 
CAGGGGCTGC TGCTGTTGCT GCTGCTGAGC ATGGGCGGGG CATGGGCATC CAGGGAGCCG 
CTTCGGCCAT GGTGCCACCC CATCAATGCC ATCCTGGCTG TCGAGAAGGA GGGCTGCCCA 
GTGTGCATCA CCGTCAACAC CACCATCTGT GCCGGCTACT GCCCCACCAT GATGCGCGTG 
CTGCAGGCGG TCCTGCCGCC CCTGCCTCAG GTGGTGTGCA CCTACCGTGA TGTGCGCTTC 
GAGTCCATCC GGCTCCCTGG CTGCCCGCGT GGTGTGGACC CCGTGGTCTC CTTCCCTGTG 
GCTCTCAGCT GTCGCTGTGG ACCCTGCCGC CGCAGCACCT CTGACTGTGG GGGTCCCAAA 
GACCACCCCT TGACCTGTGA CCACCCCCAA CTCTCAGGCC TCCTCTTCCT CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011525277.1
CDS	36..509
Translation	MGRPGLGAAVSDLGEAVSLSQGLLLLLLLSMGGAWASREPLRPWCHPINAILAVEKEGCPVCITVNTTICAGYCPTMMRVLQAVLPPLPQVVCTYRDVRFESIRLPGCPRGVDPVVSFPVALSCRCGPCRRSTSDCGGPKDHPLTCDHPQLSGLLFL

Target ORF information:

RefSeq Version	XM_011526975.1
Organism	Homo sapiens(human)
Definition	Homo sapiens luteinizing hormone beta polypeptide (LHB), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011526975.1

ORF Insert Sequence:

ATGGGAAGGC CAGGACTCGG GGCTGCGGTC TCAGACCTGG GTGAAGCAGT GTCCTTGTCC 
CAGGGGCTGC TGCTGTTGCT GCTGCTGAGC ATGGGCGGGG CATGGGCATC CAGGGAGCCG 
CTTCGGCCAT GGTGCCACCC CATCAATGCC ATCCTGGCTG TCGAGAAGGA GGGCTGCCCA 
GTGTGCATCA CCGTCAACAC CACCATCTGT GCCGGCTACT GCCCCACCAT GATGCGCGTG 
CTGCAGGCGG TCCTGCCGCC CCTGCCTCAG GTGGTGTGCA CCTACCGTGA TGTGCGCTTC 
GAGTCCATCC GGCTCCCTGG CTGCCCGCGT GGTGTGGACC CCGTGGTCTC CTTCCCTGTG 
GCTCTCAGCT GTCGCTGTGG ACCCTGCCGC CGCAGCACCT CTGACTGTGG GGGTCCCAAA 
GACCACCCCT TGACCTGTGA CCACCCCCAA CTCTCAGGCC TCCTCTTCCT CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A vital region for human glycoprotein hormone trafficking revealed by an LHB mutation.
The Journal of endocrinology231(3)197-207(2016 Dec)
Potorac I,Rivero-M?ller A,Trehan A,Kie?bus M,Jozwiak K,Pralong F,Hafidi A,Thiry A,M?nag? JJ,Huhtaniemi I,Beckers A,Daly AF

Luteinizing Hormone Secretion during Gonadotropin-Releasing Hormone Stimulation Tests in Obese Girls with Central Precocious Puberty.
Journal of clinical research in pediatric endocrinology8(4)392-398(2016 12)
Lee HS,Yoon JS,Hwang JS

A receptor-binding region in human choriogonadotropin/lutropin beta subunit.
Proceedings of the National Academy of Sciences of the United States of America84(7)2038-42(1987 Apr)
Keutmann HT,Charlesworth MC,Mason KA,Ostrea T,Johnson L,Ryan RJ

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LHB cDNA ORF clone, Homo sapiens(human)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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